LOCUS       BGC0002542             37851 bp    DNA     linear   BCT 31-MAR-2020
DEFINITION  UNVERIFIED: Moorena bouillonii bAprat14 hypothetical protein-like
            gene, partial sequence; ISAs 1 family transposase, membrane protein,
            and hypothetical protein genes, complete cds; and apratoxin A gene
            cluster, complete sequence.
ACCESSION   BGC0002542
VERSION     BGC0002542
KEYWORDS    .
SOURCE      Moorena bouillonii bAprat14
  ORGANISM  Moorena bouillonii bAprat14
            Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
            Oscillatoriales; Oscillatoriaceae; Moorena.
COMMENT     GenBank staff is unable to verify sequence and/or annotation
            provided by the submitter.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:57:38
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 37851
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     misc_feature    <1..3367
                     /note="similar to hypothetical protein; ORF1"
     source          1..37851
                     /country="Guam: Piti Bomb Holes"
                     /db_xref="taxon:2530358"
                     /mol_type="genomic DNA"
                     /organism="Moorena bouillonii bAprat14"
     protocluster    1..37851
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[12284:33484]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      12285..33484
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..37851
                     /SMILES="CC(O)CC(=O)C(C)=CNC(CS)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /detection_rules="(t2pks2 or ksIII)"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="interleaved"
                     /product="T1PKS"
                     /product="PKS-like"
                     /product="NRPS"
                     /protoclusters="1"
                     /protoclusters="2"
                     /protoclusters="3"
                     /tool="antismash"
     subregion       1..37851
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002542"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..37851
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /product="PKS-like"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /rules="(t2pks2 or ksIII)"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1414..37851
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[21413:22637]"
                     /cutoff="10000"
                     /detection_rule="(t2pks2 or ksIII)"
                     /neighbourhood="20000"
                     /product="PKS-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      21414..22637
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(t2pks2 or ksIII)"
                     /neighbourhood="20000"
                     /product="PKS-like"
                     /protocluster_number="2"
     CDS             3663..4841
                     /codon_start=1
                     /note="ORF3"
                     /product="ISAs 1 family transposase"
                     /protein_id="QBM78305.1"
                     /transl_table=11
                     /translation="MAALVLTPQQQQQALILRKSVLKHFQHLQDPRVERTQHHSLLGIV
                     TIAILAILSGADGFVAIETYGKAKLGWLETFLDLPYGIPSHDTFGRVLGRLEPQELETS
                     FLSWVSSITEKLGVRLIHIDGKRLKGSYDRESQLKALHSVSAWSSEHGLVLAQQKVESK
                     SNEIKAVPLLLKLLNLKGAVVTLDAMGTQISIAGQIKKAEGDYVLALKGNQGQLSQSVK
                     DWFKQAQAQNWQGIEFTHHQSIESGHHRRDTRQVWAVPVSQLPPLHRQPEWIGLTTVVM
                     VKTTRELWNKTTKEVRFYISSLEADAQGHNQVIRSHWTIENSLHWVLDVTFNEDASRIR
                     QGYAAQNLGLLRRLSVNLLKREPSRLSLKMKRYKAGMDNDFVIKILAASGAE"
     CDS             complement(4851..4970)
                     /codon_start=1
                     /note="ORF4"
                     /product="membrane protein"
                     /protein_id="QBM78306.1"
                     /transl_table=11
                     /translation="MHKADVFSVQVPQSALDMWLELYEEVHDLIKVVLKLALT"
     CDS             complement(6023..6277)
                     /codon_start=1
                     /note="ORF5"
                     /product="hypothetical protein"
                     /protein_id="QBM78303.1"
                     /transl_table=11
                     /translation="MSDNFRPNPENNPEDITPSNTPQEPFRKKYPIKHILKGSRQAINN
                     TMYTLYARGYAQIDEWSPLQATEIPGEFITVMTKYLTLG"
     gene            8948..12208
                     /gene="aprA"
     CDS             8948..12208
                     /NRPS_PKS="Domain: cMT (749-949). E-value: 2e-58. Score:
                     189.3. Matches aSDomain: nrpspksdomains_aprA_cMT.1"
                     /NRPS_PKS="Domain: PKS_PP (1012-1080). E-value: 2.7e-14.
                     Score: 45.2. Matches aSDomain:
                     nrpspksdomains_aprA_PKS_PP.1"
                     /codon_start=1
                     /gene="aprA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /product="polyketide synthase"
                     /protein_id="QBM78304.1"
                     /sec_met_domain="PP-binding (E-value: 6.6e-13, bitscore:
                     38.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAMRLLESLSFLYRSQAEEYILTEQSQQHQIIPKALMSLYKYPF
                     ELYLKGEVETGISNWINCSSRRWDTENSLLSDLLDGVLLIPLLLELKKQNLLDESKKIF
                     NTLTNSLKQELSTLFINLGWAEEKTEGLYLTDIGRFMRDRSLNLGTTASYAPMLLQMKE
                     LLFGNPQRVFQRNKTEKERHVNRTLNVVASGFQHEKFFADTDKIIISIFNQQPIEEQPS
                     YIVDMGCGDGTLLKRIYKIIKQFSARGKVLTEYPIIMVGVDYNQEALDVTDKNLVDIPH
                     LVIPGDIGAPEKLLEQLKAQGIEPEKVLHIRSFLDHDRPFIAPKNTEIAQARSQLDYQV
                     VDVDREGKLIPPHIAVQSLVEHLERWSSIITRHGLLLLEVHSLTPAVVKKYIDESESLH
                     FDAYHAFSMQHLVEADVFLMAAAEVGLFSRKEAFRKYPKTLPLTRITVNHFEKRKYQIR
                     YATVNDIPNLLKCATFNQPVNEPFFQVLLKQTPTAHLLLEYQGELVAAIFTETKNSNEV
                     LGIREFLVRTSVENWQVLAKDLLEFVEQWGVVKPGIKEIEGLLKYHEAISNFQKSKWYQ
                     SSVLNKKLIEKITLHELATLELCNLMAPEYELEAFAARWLLRVFQDMGVFLREGESYQE
                     SELVSQLNISPRYQRLLGALLQILHKRGILKIEKDRVFTLARCKTFALENISSEVSAFY
                     DYFSEKYPAHLSWLTVVKRCLEKYPLILRGEVDVNEVVFTDGDMELFAGLFLGHRVADY
                     FNELLADGVCWEVEQRLLEEKRAQPIRILEIGAGTGGVTGILLEKLASHAEQIEFWFTD
                     ISSVFTRYGESKFKQFPWVKYQTFDIEKSLDAQGIKSESFDVVIANNVLHNTKLIHQTL
                     NNSNSLLNTGGLLALLEFTQPIDILLYFGGLLQGFWLFEDPEYRLEVGCLLSIPLWQKV
                     LSDCGFDEIIPLGLPCEMHALSKARESVIFARKHQVQEKTFSEKIKQNLTENGKHGQAE
                     FDFISINNSQESSSKLEIFEQECRKLLKSLLGVQRMERLPGDTPLMESGMDSLELLEFR
                     ALIERKFGIKLKSTFFFSYKTLIAVAEYLSEREDINFS"
     misc_feature    8948..37851
                     /note="apratoxin A gene cluster"
     aSDomain        11195..11794
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprA_cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="2.00E-58"
                     /label="aprA_cMT.1"
                     /locus_tag="aprA"
                     /protein_end="949"
                     /protein_start="749"
                     /score="189.3"
                     /tool="antismash"
                     /translation="VADYFNELLADGVCWEVEQRLLEEKRAQPIRILEIGAGTGGVTGI
                     LLEKLASHAEQIEFWFTDISSVFTRYGESKFKQFPWVKYQTFDIEKSLDAQGIKSESFD
                     VVIANNVLHNTKLIHQTLNNSNSLLNTGGLLALLEFTQPIDILLYFGGLLQGFWLFEDP
                     EYRLEVGCLLSIPLWQKVLSDCGFDEIIPLGLPCEMH"
     aSModule        11195..12187
                     /domains="nrpspksdomains_aprA_cMT.1"
                     /domains="nrpspksdomains_aprA_PKS_PP.1"
                     /incomplete
                     /locus_tags="aprA"
                     /tool="antismash"
                     /type="pks"
     aSDomain        11984..12187
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprA_PKS_PP.1"
                     /evalue="2.70E-14"
                     /label="aprA_PKS_PP.1"
                     /locus_tag="aprA"
                     /protein_end="1080"
                     /protein_start="1012"
                     /score="45.2"
                     /tool="antismash"
                     /translation="RKLLKSLLGVQRMERLPGDTPLMESGMDSLELLEFRALIERKFGI
                     KLKSTFFFSYKTLIAVAEYLSER"
     gene            12285..21107
                     /gene="aprB"
     CDS             12285..21107
                     /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (11-441). E-value:
                     2.3e-167. Score: 549.0. Matches aSDomain:
                     nrpspksdomains_aprB_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (549-854). E-value: 2.8e-114.
                     Score: 373.3. Matches aSDomain:
                     nrpspksdomains_aprB_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_KR (1218-1396). E-value: 1.1e-66.
                     Score: 216.1. Matches aSDomain:
                     nrpspksdomains_aprB_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (1492-1569). E-value: 4.9e-19.
                     Score: 60.4. Matches aSDomain:
                     nrpspksdomains_aprB_PKS_PP.1"
                     /NRPS_PKS="Domain: PKS_PP (1606-1684). E-value: 3.6e-19.
                     Score: 60.8. Matches aSDomain:
                     nrpspksdomains_aprB_PKS_PP.2"
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (1717-2143). E-value:
                     1.4e-188. Score: 618.9. Matches aSDomain:
                     nrpspksdomains_aprB_PKS_KS.2"
                     /NRPS_PKS="Domain: PKS_AT (2255-2553). E-value: 6.9e-112.
                     Score: 365.5. Matches aSDomain:
                     nrpspksdomains_aprB_PKS_AT.2"
                     /NRPS_PKS="Domain: ACP_beta (2699-2765). E-value: 7.5e-30.
                     Score: 94.4. Matches aSDomain:
                     nrpspksdomains_aprB_ACP_beta.1"
                     /NRPS_PKS="Domain: ACP_beta (2808-2874). E-value: 1.6e-29.
                     Score: 93.3. Matches aSDomain:
                     nrpspksdomains_aprB_ACP_beta.2"
                     /codon_start=1
                     /gene="aprB"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     hyb_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     tra_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     60; E-value: 4.3e-18)"
                     /gene_kind="biosynthetic"
                     /product="polyketide synthase"
                     /protein_id="QBM78307.1"
                     /sec_met_domain="tra_KS (E-value: 3.1e-171, bitscore:
                     559.4, seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 5.5e-115, bitscore:
                     373.3, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 2.5e-60, bitscore:
                     193.0, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 1.2e-208, bitscore:
                     682.7, seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 7.5e-16, bitscore:
                     48.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHSNQSSSLARIAIVGVACRFPGADTKEEFWQLLKEGRDSMQNLP
                     SERWGNLFNSMSSEIDLSIQRGGFLKDIDLFDSSFFRITPREAQLMDPQQRLLLELSWE
                     AMEDAGYARDTLKGKSVGVYVGVCHYDYRSLLEKGLETAEIAQIATGTAPATFANRLSY
                     FYNFHGPSLTVDTACSSSLVAMYEAVNAIRRGQCQTALVGGVNLMCSPVNNQVYSAAGM
                     LSPDGVCRVFDAGANGFVRGEGGAVVVLKDYQKALTDGDSIYGVVRSVAVNHGGQASSF
                     TAPNPQAQAKLLEQAYREANIDIESVGYIEAHGTGTSLGDPIEVEALNEAFKGLSSSGK
                     LPANSCGLGSVKTNIGHLEGAAGLAGLIKVLLCMRYATLPCSLNYQQLNPDIELEEGPF
                     FVVDKLQSWEIKVDRVGKPYPLRAGLSSFGFGGTNAHVVLEEGENKKEGRRGDKEPSVH
                     LLTLSAKTETALSELVSRYQKYLNTNAESELADICYTANTGRVHFNHRLAAIASNKQEL
                     VEKLKEYQAGEATAGVLIGELAERIRTPKLGFLFTGQGSQYVNMGKQLYKTQPVFREVL
                     DKCDIILETEIECSLLDVLYNKTTDSQDSSLINQTAYTQPVLFAIEYALFKLWESWGIK
                     PSIVMGHSVGEYVAACVAGVFNLEDGLRLIAARGRLMQQLPSGGEMVSVMASESTVSRL
                     LEPHKKEIALAKPAVGIAAINGPESTVISGDSVAVTGVVNDLEAKGIKTKKLEVSHAFH
                     SPLMEPMLGEFEAIANQLTYNQPKIPIISNVTGTKADNTIASPQYWVNHVGKPVRFAQG
                     METLHQQGYETFIEVGPKPVLLGMGRQCLPGNVGVWLPSLRPGVDEWQQMLYSLGKLYV
                     TGVKIDWSGFESDSSRQKVALPTYPFQRERYWIEITENKHKEHQKSENISDTSIVKLLT
                     QGKTEALTQQLETEAKFSPEELKLLPEILETLAKQHQEQLTAVTIKNWFYEIQWKPLAQ
                     NNPNANIEPSHWLILADTTGVAEKLAQKLQQQGHKYSLVYRGESYQRQATGTYQLNPQI
                     PEAFEKLYQEIQQSSETAITKLIHLWSLDAPQSKDLTLETLEEAQLWGCGSVVHLLQTL
                     VKNSSIPELWLVTRGSQSVLSQTEKNLTGLAASPLWGLGRVVSNEHPQLWGGLVDLDPQ
                     AAAGDEVEMLWQLLVNEQEEDNLAVRGENTYVARLARQEPQEFPESLSLSSDGSYLITG
                     GLGALGLHTAQWLVSKGAKNIVLTGRRPPSEKVSESIKKLEETGCQVKVMLGDVSVEED
                     IGKILKQIQISMPTLKGIIHTAGVLDDGTIQQMNWERFAKVMSPKVKGSWHLHKLTENQ
                     PLDFFVCFSSIASMLGTLGQGNYAAANAFMDALASYRCSRGLSGLAINWGAWASGGMAA
                     RLAVEHQNRMHSSGITEMATKEGMYALDLLLTNESATAQVGVASIEWQVLSESWSGIKK
                     NSLLRELLEKEEWAAKDTRHQKVKAEFLAKLEEASLEKRQEILTEHIRVQVSQVLGLSS
                     SKLPEVNVGFASMGMDSLMTIELKNRLQNQLGTKLPETIAIEYPTIAKLSLGIKKNSLL
                     RELLEKEEWAAKDTRHQKVKAEFLAKLEEASLEKRQEILTEHIRVQVSQVLGLSSSKLP
                     EVNVGFASMGMDSLMTIELKNRLQNQLGTKLPETIAIEYPTIAKLSLCIEELMGWKTTE
                     IDPLSEETRLEMMERSRSEAIAIIGIGCRFPGNANTPESFWQLLSNGKDSITEIPLERW
                     DLDSYYDPNPDTPGKMYIRHAALVEKVDQFDPRFFGISNREAYSLDPQQRFILEVTWEA
                     LERAGINPQQLENTQTGVFLGIGQNDYANLGFHQAAEDISPYDATGNLFCFVAGRLSYF
                     LGTQGPSMAIDTACSSSLVAIHEACESLRQGESNLALAGGVQLILSPEVTTALSRLKAL
                     APDGKCKTFDAAADGFGRGEGCGIVVLKRLSDALKDGDRISAVIPGSAVNHDGPSSGMT
                     VPNKLAQEKLIQKALKAAKVKPLQVSYVEAHGTGTSLGDPMEVRALARVFEEGRDQENP
                     LNIGSVKTNIGHLEAAAGIAGMIKVILQLQHQEIVPHLHFANPNPYVDWENMPLQVPTQ
                     LTPWLSKGEKRVAGVSSFGMSGTNAHIVLEEAPIEVRRQKSEVRSEEYLERPVHILTLS
                     AKTEKALEDLVNSYESYLEAENNDNYLGDICYTANIGRAKFDHKLAVVTSDKQELLEKL
                     KQYKQGENVAGIFSGKQISETRTKIAFIFTGQGSQYLQMGRQLYETQPTFHKIIDQCSE
                     MLVKYLDVSLLDILYPVEVKDESSTLIDQTAYTQPAIFALEYALAKLWESWGIKPDVVM
                     GHSVGEYVAATVAGVFSLEDGLKLIAMRGQLMQKLPSGGQMASIMASESQVIEAIKEYS
                     SQVTIAAVNGPEIIVISGESPAISKICSKFESEGVKTKALQVSHAFHSPLMEPMLTEFE
                     AVAKEISYNHPQIPLISNVTGQEVNGEITTAEYWVRHVRQPVRFAEGMETLHKQGAEIF
                     LEIGSKPILLGMGRECLMGEKKLWLPSLRSGKPDWLQMLQSLGQLYVRAIKIDWLGFDR
                     DYFRNKVELPTYPWQRKRYWITDIRQRKSQDKKSITSEKKVQLDGVNIQLKEIQMNDKI
                     LQQPKLKLSDPESLYLSNAESTIEVPTKAVQVKPAADIESENITQLNSLDRDVTQIIET
                     LKESLADALYADISEIEEDKKFVDLGLDSIVGVEWITNINKIYNLNIKATKLYDYPTLP
                     DLAKYVAHTLSAQGRNIDVERSPSDSSQASISKQSQLTDTQSNFSQVKEILKQQLADAL
                     YADISEIEVNKKFVDLGLDSIVGVEWITNINKTYNLNIKATKIYDYPTLLDFAKYINQE
                     IYSTGVSRFSTEHKEFNQKDYSSGGSQEEMTQKLRSILKKVANKELTVQEGNKMIQQIK
                     NQLK"
     aSDomain        12318..13607
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprB_PKS_KS.1"
                     /domain_subtypes="Trans-AT-KS"
                     /evalue="2.30E-167"
                     /label="aprB_PKS_KS.1"
                     /locus_tag="aprB"
                     /protein_end="441"
                     /protein_start="11"
                     /score="549.0"
                     /specificity="transATor: (unknown)"
                     /tool="antismash"
                     /translation="IAIVGVACRFPGADTKEEFWQLLKEGRDSMQNLPSERWGNLFNSM
                     SSEIDLSIQRGGFLKDIDLFDSSFFRITPREAQLMDPQQRLLLELSWEAMEDAGYARDT
                     LKGKSVGVYVGVCHYDYRSLLEKGLETAEIAQIATGTAPATFANRLSYFYNFHGPSLTV
                     DTACSSSLVAMYEAVNAIRRGQCQTALVGGVNLMCSPVNNQVYSAAGMLSPDGVCRVFD
                     AGANGFVRGEGGAVVVLKDYQKALTDGDSIYGVVRSVAVNHGGQASSFTAPNPQAQAKL
                     LEQAYREANIDIESVGYIEAHGTGTSLGDPIEVEALNEAFKGLSSSGKLPANSCGLGSV
                     KTNIGHLEGAAGLAGLIKVLLCMRYATLPCSLNYQQLNPDIELEEGPFFVVDKLQSWEI
                     KVDRVGKPYPLRAGLSSFGFGGTNAHVVLEE"
     aSModule        12318..16991
                     /complete
                     /domains="nrpspksdomains_aprB_PKS_KS.1"
                     /domains="nrpspksdomains_aprB_PKS_AT.1"
                     /domains="nrpspksdomains_aprB_PKS_KR.1"
                     /domains="nrpspksdomains_aprB_PKS_PP.1"
                     /locus_tags="aprB"
                     /monomer_pairings="mal -> ohmal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       12558..12584
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0001"
                     /evalue="5.30E-02"
                     /label="PKSI-KS_m2"
                     /locus_tag="aprB"
                     /protein_end="100"
                     /protein_start="91"
                     /score="6.8"
                     /tool="antismash"
                     /translation="DPQQRLLLE"
     CDS_motif       12789..12836
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0002"
                     /evalue="7.70E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="aprB"
                     /protein_end="184"
                     /protein_start="168"
                     /score="20.9"
                     /tool="antismash"
                     /translation="GPSLTVDTACSSSLVA"
     CDS_motif       12978..13016
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0003"
                     /evalue="1.70E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="aprB"
                     /protein_end="244"
                     /protein_start="231"
                     /score="11.6"
                     /tool="antismash"
                     /translation="FDAGANGFVRGEG"
     CDS_motif       13209..13256
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0004"
                     /evalue="2.70E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="aprB"
                     /protein_end="324"
                     /protein_start="308"
                     /score="13.1"
                     /tool="antismash"
                     /translation="YIEAHGTGTSLGDPIE"
     CDS_motif       13329..13373
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0005"
                     /evalue="1.10E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="aprB"
                     /protein_end="363"
                     /protein_start="348"
                     /score="11.5"
                     /tool="antismash"
                     /translation="GSVKTNIGHLEGAAG"
     protocluster    13481..37851
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[33480:37011]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="3"
                     /tool="antismash"
     proto_core      33481..37011
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="3"
     aSDomain        13932..14846
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprB_PKS_AT.1"
                     /evalue="2.80E-114"
                     /label="aprB_PKS_AT.1"
                     /locus_tag="aprB"
                     /protein_end="854"
                     /protein_start="549"
                     /score="373.3"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFTGQGSQYVNMGKQLYKTQPVFREVLDKCDIILETEIECSLLDV
                     LYNKTTDSQDSSLINQTAYTQPVLFAIEYALFKLWESWGIKPSIVMGHSVGEYVAACVA
                     GVFNLEDGLRLIAARGRLMQQLPSGGEMVSVMASESTVSRLLEPHKKEIALAKPAVGIA
                     AINGPESTVISGDSVAVTGVVNDLEAKGIKTKKLEVSHAFHSPLMEPMLGEFEAIANQL
                     TYNQPKIPIISNVTGTKADNTIASPQYWVNHVGKPVRFAQGMETLHQQGYETFIEVGPK
                     PVLLGMGRQCLPGNVGVWLPSLRP"
     CDS_motif       13935..13982
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0006"
                     /evalue="2.60E-06"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="aprB"
                     /protein_end="566"
                     /protein_start="550"
                     /score="19.7"
                     /tool="antismash"
                     /translation="FTGQGSQYVNMGKQLY"
     CDS_motif       14121..14177
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0007"
                     /evalue="5.10E-04"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="aprB"
                     /protein_end="631"
                     /protein_start="612"
                     /score="13.3"
                     /tool="antismash"
                     /translation="YTQPVLFAIEYALFKLWES"
     CDS_motif       14181..14303
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0008"
                     /evalue="3.60E-28"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="aprB"
                     /protein_end="673"
                     /protein_start="632"
                     /score="90.0"
                     /tool="antismash"
                     /translation="GIKPSIVMGHSVGEYVAACVAGVFNLEDGLRLIAARGRLMQ"
     CDS_motif       14418..14456
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0009"
                     /evalue="1.80E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="aprB"
                     /protein_end="724"
                     /protein_start="711"
                     /score="14.7"
                     /tool="antismash"
                     /translation="AAINGPESTVISG"
     CDS_motif       14520..14546
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0010"
                     /evalue="3.90E-02"
                     /label="PKSI-AT-M_m6"
                     /locus_tag="aprB"
                     /protein_end="754"
                     /protein_start="745"
                     /score="7.3"
                     /tool="antismash"
                     /translation="LEVSHAFHS"
     CDS_motif       14610..14642
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0011"
                     /evalue="1.20E-02"
                     /label="PKSI-AT-M_m7"
                     /locus_tag="aprB"
                     /protein_end="786"
                     /protein_start="775"
                     /score="8.7"
                     /tool="antismash"
                     /translation="PKIPIISNVTG"
     CDS_motif       14676..14711
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0012"
                     /evalue="3.40E-03"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="aprB"
                     /protein_end="809"
                     /protein_start="797"
                     /score="11.0"
                     /tool="antismash"
                     /translation="YWVNHVGKPVRF"
     CDS_motif       14754..14783
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0013"
                     /evalue="5.60E-02"
                     /label="PKSI-AT-M_m9"
                     /locus_tag="aprB"
                     /protein_end="833"
                     /protein_start="823"
                     /score="6.9"
                     /tool="antismash"
                     /translation="FIEVGPKPVL"
     aSDomain        15939..16472
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprB_PKS_KR.1"
                     /evalue="1.10E-66"
                     /label="aprB_PKS_KR.1"
                     /locus_tag="aprB"
                     /protein_end="1396"
                     /protein_start="1218"
                     /score="216.1"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: B1"
                     /tool="antismash"
                     /translation="GSYLITGGLGALGLHTAQWLVSKGAKNIVLTGRRPPSEKVSESIK
                     KLEETGCQVKVMLGDVSVEEDIGKILKQIQISMPTLKGIIHTAGVLDDGTIQQMNWERF
                     AKVMSPKVKGSWHLHKLTENQPLDFFVCFSSIASMLGTLGQGNYAAANAFMDALASYRC
                     SRGLSGLAINWGAWA"
     CDS_motif       15942..16040
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0014"
                     /evalue="5.50E-17"
                     /label="PKSI-KR_m1"
                     /locus_tag="aprB"
                     /protein_end="1252"
                     /protein_start="1219"
                     /score="54.3"
                     /tool="antismash"
                     /translation="SYLITGGLGALGLHTAQWLVSKGAKNIVLTGRR"
     CDS_motif       16266..16295
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0015"
                     /evalue="4.80E-03"
                     /label="PKSI-KR_m3"
                     /locus_tag="aprB"
                     /protein_end="1337"
                     /protein_start="1327"
                     /score="10.4"
                     /tool="antismash"
                     /translation="PKVKGSWHLH"
     CDS_motif       16317..16424
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0016"
                     /evalue="1.50E-21"
                     /label="PKSI-KR_m4"
                     /locus_tag="aprB"
                     /protein_end="1380"
                     /protein_start="1344"
                     /score="68.9"
                     /tool="antismash"
                     /translation="LDFFVCFSSIASMLGTLGQGNYAAANAFMDALASYR"
     aSDomain        16761..16991
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprB_PKS_PP.1"
                     /evalue="4.90E-19"
                     /label="aprB_PKS_PP.1"
                     /locus_tag="aprB"
                     /protein_end="1569"
                     /protein_start="1492"
                     /score="60.4"
                     /tool="antismash"
                     /translation="EEASLEKRQEILTEHIRVQVSQVLGLSSSKLPEVNVGFASMGMDS
                     LMTIELKNRLQNQLGTKLPETIAIEYPTIAKL"
     aSDomain        17103..17336
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprB_PKS_PP.2"
                     /evalue="3.60E-19"
                     /label="aprB_PKS_PP.2"
                     /locus_tag="aprB"
                     /protein_end="1684"
                     /protein_start="1606"
                     /score="60.8"
                     /tool="antismash"
                     /translation="EEASLEKRQEILTEHIRVQVSQVLGLSSSKLPEVNVGFASMGMDS
                     LMTIELKNRLQNQLGTKLPETIAIEYPTIAKLS"
     aSDomain        17436..18713
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprB_PKS_KS.2"
                     /domain_subtypes="Hybrid-KS"
                     /evalue="1.40E-188"
                     /label="aprB_PKS_KS.2"
                     /locus_tag="aprB"
                     /protein_end="2143"
                     /protein_start="1717"
                     /score="618.9"
                     /tool="antismash"
                     /translation="IAIIGIGCRFPGNANTPESFWQLLSNGKDSITEIPLERWDLDSYY
                     DPNPDTPGKMYIRHAALVEKVDQFDPRFFGISNREAYSLDPQQRFILEVTWEALERAGI
                     NPQQLENTQTGVFLGIGQNDYANLGFHQAAEDISPYDATGNLFCFVAGRLSYFLGTQGP
                     SMAIDTACSSSLVAIHEACESLRQGESNLALAGGVQLILSPEVTTALSRLKALAPDGKC
                     KTFDAAADGFGRGEGCGIVVLKRLSDALKDGDRISAVIPGSAVNHDGPSSGMTVPNKLA
                     QEKLIQKALKAAKVKPLQVSYVEAHGTGTSLGDPMEVRALARVFEEGRDQENPLNIGSV
                     KTNIGHLEAAAGIAGMIKVILQLQHQEIVPHLHFANPNPYVDWENMPLQVPTQLTPWLS
                     KGEKRVAGVSSFGMSGTNAHIVLEEAP"
     aSModule        17436..20579
                     /complete
                     /domains="nrpspksdomains_aprB_PKS_KS.2"
                     /domains="nrpspksdomains_aprB_PKS_AT.2"
                     /domains="nrpspksdomains_aprB_ACP_beta.1"
                     /locus_tags="aprB"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       17688..17714
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0017"
                     /evalue="6.60E-01"
                     /label="PKSI-KS_m2"
                     /locus_tag="aprB"
                     /protein_end="1810"
                     /protein_start="1801"
                     /score="3.8"
                     /tool="antismash"
                     /translation="DPQQRFILE"
     CDS_motif       17919..17966
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0018"
                     /evalue="8.40E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="aprB"
                     /protein_end="1894"
                     /protein_start="1878"
                     /score="20.8"
                     /tool="antismash"
                     /translation="GPSMAIDTACSSSLVA"
     CDS_motif       18108..18146
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0019"
                     /evalue="6.00E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="aprB"
                     /protein_end="1954"
                     /protein_start="1941"
                     /score="10.0"
                     /tool="antismash"
                     /translation="FDAAADGFGRGEG"
     CDS_motif       18339..18386
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0020"
                     /evalue="3.10E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="aprB"
                     /protein_end="2034"
                     /protein_start="2018"
                     /score="12.9"
                     /tool="antismash"
                     /translation="YVEAHGTGTSLGDPME"
     CDS_motif       18447..18491
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0021"
                     /evalue="5.70E-04"
                     /label="PKSI-KS_m6"
                     /locus_tag="aprB"
                     /protein_end="2069"
                     /protein_start="2054"
                     /score="12.3"
                     /tool="antismash"
                     /translation="GSVKTNIGHLEAAAG"
     aSDomain        19050..19943
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprB_PKS_AT.2"
                     /evalue="6.90E-112"
                     /label="aprB_PKS_AT.2"
                     /locus_tag="aprB"
                     /protein_end="2553"
                     /protein_start="2255"
                     /score="365.5"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="IFTGQGSQYLQMGRQLYETQPTFHKIIDQCSEMLVKYLDVSLLDI
                     LYPVEVKDESSTLIDQTAYTQPAIFALEYALAKLWESWGIKPDVVMGHSVGEYVAATVA
                     GVFSLEDGLKLIAMRGQLMQKLPSGGQMASIMASESQVIEAIKEYSSQVTIAAVNGPEI
                     IVISGESPAISKICSKFESEGVKTKALQVSHAFHSPLMEPMLTEFEAVAKEISYNHPQI
                     PLISNVTGQEVNGEITTAEYWVRHVRQPVRFAEGMETLHKQGAEIFLEIGSKPILLGMG
                     RECLMGEKKLWLPSLRS"
     CDS_motif       19053..19100
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0022"
                     /evalue="1.30E-05"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="aprB"
                     /protein_end="2272"
                     /protein_start="2256"
                     /score="17.7"
                     /tool="antismash"
                     /translation="FTGQGSQYLQMGRQLY"
     CDS_motif       19236..19295
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0023"
                     /evalue="4.00E-04"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="aprB"
                     /protein_end="2337"
                     /protein_start="2317"
                     /score="13.6"
                     /tool="antismash"
                     /translation="AYTQPAIFALEYALAKLWES"
     CDS_motif       19299..19421
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0024"
                     /evalue="3.30E-28"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="aprB"
                     /protein_end="2379"
                     /protein_start="2338"
                     /score="90.2"
                     /tool="antismash"
                     /translation="GIKPDVVMGHSVGEYVAATVAGVFSLEDGLKLIAMRGQLMQ"
     CDS_motif       19515..19553
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0025"
                     /evalue="5.00E-03"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="aprB"
                     /protein_end="2423"
                     /protein_start="2410"
                     /score="10.3"
                     /tool="antismash"
                     /translation="AAVNGPEIIVISG"
     CDS_motif       19617..19643
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0026"
                     /evalue="4.60E-02"
                     /label="PKSI-AT-M_m6"
                     /locus_tag="aprB"
                     /protein_end="2453"
                     /protein_start="2444"
                     /score="7.1"
                     /tool="antismash"
                     /translation="LQVSHAFHS"
     CDS_motif       19707..19739
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0027"
                     /evalue="3.30E-03"
                     /label="PKSI-AT-M_m7"
                     /locus_tag="aprB"
                     /protein_end="2485"
                     /protein_start="2474"
                     /score="10.2"
                     /tool="antismash"
                     /translation="PQIPLISNVTG"
     CDS_motif       19773..19808
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0028"
                     /evalue="6.10E-05"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="aprB"
                     /protein_end="2508"
                     /protein_start="2496"
                     /score="16.3"
                     /tool="antismash"
                     /translation="YWVRHVRQPVRF"
     CDS_motif       19851..19880
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprB_0029"
                     /evalue="1.30E+00"
                     /label="PKSI-AT-M_m9"
                     /locus_tag="aprB"
                     /protein_end="2532"
                     /protein_start="2522"
                     /score="2.9"
                     /tool="antismash"
                     /translation="FLEIGSKPIL"
     aSDomain        20382..20579
                     /aSDomain="ACP_beta"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprB_ACP_beta.1"
                     /evalue="7.50E-30"
                     /label="aprB_ACP_beta.1"
                     /locus_tag="aprB"
                     /protein_end="2765"
                     /protein_start="2699"
                     /score="94.4"
                     /tool="antismash"
                     /translation="TLKESLADALYADISEIEEDKKFVDLGLDSIVGVEWITNINKIYN
                     LNIKATKLYDYPTLPDLAKYV"
     aSDomain        20709..20906
                     /aSDomain="ACP_beta"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprB_ACP_beta.2"
                     /evalue="1.60E-29"
                     /label="aprB_ACP_beta.2"
                     /locus_tag="aprB"
                     /protein_end="2874"
                     /protein_start="2808"
                     /score="93.3"
                     /tool="antismash"
                     /translation="ILKQQLADALYADISEIEVNKKFVDLGLDSIVGVEWITNINKTYN
                     LNIKATKIYDYPTLLDFAKYI"
     gene            21142..21402
                     /gene="aprC"
     CDS             21142..21402
                     /NRPS_PKS="Domain: PP-binding (20-73). E-value: 2.1e-11.
                     Score: 36.1. Matches aSDomain:
                     nrpspksdomains_aprC_PP-binding.1"
                     /codon_start=1
                     /gene="aprC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /product="acyl carrier protein"
                     /protein_id="QBM78308.1"
                     /sec_met_domain="PP-binding (E-value: 4.1e-12, bitscore:
                     36.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKEQIFQIIKKYTYEIAPELEEVPISPTDSLKNLGIDSVNRAEI
                     IMMVMEELSLNIPRIELAGSKNIGELADIFAFKLEAINSQS"
     aSDomain        21202..21360
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprC_PP-binding.1"
                     /evalue="2.10E-11"
                     /label="aprC_PP-binding.1"
                     /locus_tag="aprC"
                     /protein_end="73"
                     /protein_start="20"
                     /score="36.1"
                     /tool="antismash"
                     /translation="LEEVPISPTDSLKNLGIDSVNRAEIIMMVMEELSLNIPRIELAGS
                     KNIGELAD"
     gene            21414..22637
                     /gene="aprD"
     CDS             21414..22637
                     /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (78-404). E-value:
                     3.9e-51. Score: 166.1. Matches aSDomain:
                     nrpspksdomains_aprD_PKS_KS.1"
                     /codon_start=1
                     /gene="aprD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PKS-like: t2pks2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 339.6; E-value:
                     4.5e-103)"
                     /gene_kind="biosynthetic"
                     /product="beta-ketoacyl synthase"
                     /protein_id="QBM78309.1"
                     /sec_met_domain="t2pks2 (E-value: 5.2e-181, bitscore:
                     591.4, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNIEITGMGIVTSIGQGVATFKEALLSGKTQFAYLKQPGRESIK
                     PFIGAEIPDIDAKTLFPEYSGLLRTATKSAQVAIVAVAEAWQDAQLTSSQVNPERVGLV
                     VGGSNLQQRYQQQTWQRYHSRQEFIRPTYGLTFWDTDILGLISQCFQIQGEGYSVGGAS
                     ASGAVAIIHAARQILMGNSDVCIALGALSDLSGYEFQALMNLGAMGSERFADRPNLACR
                     PFDQDHDGFIYGEGCGAVILERTDRAQQRGAQSHGQLKGWGLTLDGNRSPEPSQKGEER
                     AINTALAMADLQPESIDYVNTHGTGSPLGDKTEVAAFKSVGLQHCLFNSTKSLIGHCLT
                     AAGVVEAIATILQMKFGFCHPTKNLVNPIDTSLNWVKETSVQAEIKYAISNSFGFGGIN
                     TALLIGQE"
     aSDomain        21648..22625
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprD_PKS_KS.1"
                     /domain_subtypes="Trans-AT-KS"
                     /evalue="3.90E-51"
                     /label="aprD_PKS_KS.1"
                     /locus_tag="aprD"
                     /protein_end="404"
                     /protein_start="78"
                     /score="166.1"
                     /specificity="transATor: (unknown)"
                     /tool="antismash"
                     /translation="IVAVAEAWQDAQLTSSQVNPERVGLVVGGSNLQQRYQQQTWQRYH
                     SRQEFIRPTYGLTFWDTDILGLISQCFQIQGEGYSVGGASASGAVAIIHAARQILMGNS
                     DVCIALGALSDLSGYEFQALMNLGAMGSERFADRPNLACRPFDQDHDGFIYGEGCGAVI
                     LERTDRAQQRGAQSHGQLKGWGLTLDGNRSPEPSQKGEERAINTALAMADLQPESIDYV
                     NTHGTGSPLGDKTEVAAFKSVGLQHCLFNSTKSLIGHCLTAAGVVEAIATILQMKFGFC
                     HPTKNLVNPIDTSLNWVKETSVQAEIKYAISNSFGFGGINTALLI"
     CDS_motif       22308..22355
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprD_0001"
                     /evalue="5.00E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="aprD"
                     /protein_end="314"
                     /protein_start="298"
                     /score="9.7"
                     /tool="antismash"
                     /translation="YVNTHGTGSPLGDKTE"
     gene            22642..23901
                     /gene="aprE"
     CDS             22642..23901
                     /codon_start=1
                     /gene="aprE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043:hydroxymethylglutaryl-CoA synthase (Score: 475.3;
                     E-value: 2.3e-144)"
                     /gene_kind="biosynthetic-additional"
                     /product="HMG-CoA synthase-like enzyme"
                     /protein_id="QBM78310.1"
                     /transl_table=11
                     /translation="MQQVGIEALNVYGGSAKLDVRMLGEARHLDMTRFDNLLMKEKTVA
                     MPYEDPVSYAINAAKPIIDSLSVLEKQQIKMVIACSESGIDFGKSMSTYIQDYLGLNRN
                     CRMFEIKQACYSGTAGLQMAFNLILSQTCPGAKALVIGTDIFRPVVVEGGEALSEDWSF
                     VEPSSGAGAVAILVSDVPKIFQADVGCNGYYGYEVMDTCRPNPDSEAGDADLSLLSYLD
                     CCENAYREYQDRVEGVDYQKTFDYLSFHTPFGGMVKGAHRSMMRKFKRAKPVEIEEDFQ
                     KRVMPGLVYCQQVGNIMGATVFLSLASMIDNADFSKARRIGVFSYGSGCCSEFYSGVVT
                     PQGKEIQAQQKISSQLAMRYSLSMEEYEQLLSHSSAVAFGTRNVTLDYKLFPGVWEQIE
                     GKGRLVLKRIKEFHREYEWV"
     gene            23892..24668
                     /gene="aprF"
     CDS             23892..24668
                     /NRPS_PKS="Domain: ECH (14-250). E-value: 2.4e-47. Score:
                     153.2. Matches aSDomain: nrpspksdomains_aprF_ECH.1"
                     /codon_start=1
                     /gene="aprF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023:enoyl-CoA hydratase (Score: 168.4; E-value:
                     2.6e-51)"
                     /gene_kind="biosynthetic-additional"
                     /product="enoyl-CoA hydratase"
                     /protein_id="QBM78311.1"
                     /transl_table=11
                     /translation="MGIAMSYQTLKISYQDVVQRIQIYRPESNNSINSQLTMELLSALQ
                     AAEAEEVVKVVILEGLPDVFCTGMDFEEVATAKQFDPKASANGYYNILKQMSQSSKVIL
                     SLVRGKVQAGGVGLVAASDLVIADETATFVLSELLFGLLPACVLPFLIRRVGFQKAYRL
                     ALTTQAISVSEADKWGLIDEYGSNINQLISKYIRRLKYLPSSGVKELKNYINQLWIIQA
                     ETQGLAVNEISSLIAEPTVQEKIKRFQKEGLFPWQT"
     aSDomain        23934..24641
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprF_ECH.1"
                     /evalue="2.40E-47"
                     /label="aprF_ECH.1"
                     /locus_tag="aprF"
                     /protein_end="250"
                     /protein_start="14"
                     /score="153.2"
                     /tool="antismash"
                     /translation="QDVVQRIQIYRPESNNSINSQLTMELLSALQAAEAEEVVKVVILE
                     GLPDVFCTGMDFEEVATAKQFDPKASANGYYNILKQMSQSSKVILSLVRGKVQAGGVGL
                     VAASDLVIADETATFVLSELLFGLLPACVLPFLIRRVGFQKAYRLALTTQAISVSEADK
                     WGLIDEYGSNINQLISKYIRRLKYLPSSGVKELKNYINQLWIIQAETQGLAVNEISSLI
                     AEPTVQEKIKRFQK"
     gene            24656..33484
                     /gene="aprG"
     CDS             24656..33484
                     /NRPS_PKS="Domain: ECH (20-255). E-value: 1.7e-47. Score:
                     153.6. Matches aSDomain: nrpspksdomains_aprG_ECH.1"
                     /NRPS_PKS="Domain: PKS_ER (297-616). E-value: 1.3e-98.
                     Score: 321.9. Matches aSDomain:
                     nrpspksdomains_aprG_PKS_ER.1"
                     /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (742-1168). E-value:
                     2e-170. Score: 559.2. Matches aSDomain:
                     nrpspksdomains_aprG_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (1271-1569). E-value: 7.6e-118.
                     Score: 385.0. Matches aSDomain:
                     nrpspksdomains_aprG_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH2 (1664-1877). E-value: 5e-38.
                     Score: 122.6. Matches aSDomain:
                     nrpspksdomains_aprG_PKS_DH2.1"
                     /NRPS_PKS="Domain: cMT (2111-2323). E-value: 3.8e-113.
                     Score: 369.9. Matches aSDomain: nrpspksdomains_aprG_cMT.1"
                     /NRPS_PKS="Domain: PKS_KR (2567-2745). E-value: 2.3e-62.
                     Score: 202.0. Matches aSDomain:
                     nrpspksdomains_aprG_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (2831-2917). E-value: 2.1e-23.
                     Score: 74.4. Matches aSDomain:
                     nrpspksdomains_aprG_PKS_PP.1"
                     /codon_start=1
                     /gene="aprG"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     tra_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 254; E-value:
                     4.3e-77)"
                     /gene_kind="biosynthetic"
                     /product="polyketide synthase"
                     /protein_id="QBM78312.1"
                     /sec_met_domain="ADH_N (E-value: 3.9e-09, bitscore: 26.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.5e-19, bitscore:
                     58.3, seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 2.2e-175, bitscore:
                     573.1, seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.5e-118, bitscore:
                     385.0, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 4.3e-57, bitscore:
                     182.4, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 7.6e-15, bitscore:
                     44.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANLNLNLDLVEGNSDVVQLVELGNGVVQITMKDEESCNGFSPGI
                     IEGLYKCFGAVAQNQSYKVVILTGYGNYFCSGGTKERLISIWKGDSKCNDLDFFRIALD
                     CEIPVIAAMQGHSIGGGLVLGLYADLVVLSQESIYTTNFMKYGFTPGVGCTLILPEKFG
                     ALGFEMMYTAQNYRGKELAERGVSFPVVPRKDVLEVAKNIAYEMSEKPRLSLITLKEHL
                     TSKIRKTLPGFIDKEVAMHEITFHQPEVASRIEENFDKRTTASNNPQNFPQEAVRKEIR
                     TDSLNCQPFQLKTFSYGSLNNLTLVPLERRVPSPSEVEVQIKTVPVNFRDILNALGMLQ
                     EYYEKTFGIANAEDLTFGFEGAGTIVAVGAEVSQWQVGDEVMVMRIHDAFSSFIICSPD
                     KLVRKNFNLNMEDGASIWGPFSTAYHGLINLAKIQPGDRVLIHAASGGIGQAAIQLAQL
                     FGAEVFATTSPGKMNYLREQGIKYVMNSRTMEFVNDVMEFTQGRGVDVILNSLTHGEYI
                     QKNLEILADRGRYVELGKLGIWSHEQVYQKRPDIKYFTFDLLEEFAKDNQLFSQIWDNL
                     ALEFDRDRLKPLPYKTFPIEDVLKAFDYMRRGKHFGRVVVVMPDSYSRQEQELDARLSI
                     ENKMTKEEQILFQLQSGEVSLENAEQLLLGNTETETQDKAIAENQIDNIQNKLINMDSS
                     EKILSLISSVEISLETAEKLLLEVVEPEVKTEVNDEVNPSQNHIPTTDIAIIGISCRYP
                     GANNWKEFWENLKNGIDSVTEAPPGRWEEKNWYHPDPDNPGTSYSKCAGFLDEIDKFDP
                     LFFHISPEEAWFMEPEQRIFLEEAYHAIEDAGYATDSLRGKQYGVFVGVTVNGGYLKLL
                     SISGLDVHRMAATGNGPSMIPARIAYMLDLQGPVVAIDTACSSSLVAVHQACQSIQRGE
                     SEIAIAGGITLMPTSDFQIMSSQFQVVSPDGRCKTFDASASGTAWSEGCGVLLLKSYSQ
                     AIQDNDHIYGVIKGTGVNYDGNTNGISAPSSQSQASLEEAVYQKFGINPETISYVEAHG
                     TATPLGDPIEVEALTEAFSKWTNKKQFCAIGSVKTNIGHSAAAAGVSGLIKTILCLKNQ
                     KLVPSLHFNQPNPHIDFENSPFYVNTKLKDWEVLEGQPRQATVSSFGFSGTNAHIVIEE
                     APSQVKSQNIVERPIHLLTLSAKTEKALEDLVSNYQNYLETNPELPLADVCYTASTGRA
                     HFNYRLGVIASEPKALIEKLLGWKAQEELVGLFSGKRNSEGQKIAFLFTGQGSQYANMG
                     RQLYEKAPTFRQALEECDQILQPYLEVPLLEVIYSEDAQKSSDNLLDQTAYTQPAVFAV
                     EYALAKLWSSWGIKPCVVMGHSVGEYVAATVAGVFSLEDGLKLIAMRGKLMQKLPSGGE
                     MVSVMASESQVTEAIKEYSSQVTIAAINGPESIVISGESVAIKNICSLFESEGIKTKQL
                     QVSHAFHSPMMEPMLAEFESVAKQVTYNQPQIPLISNVTGTEVDGEITNAEYWVDHVRQ
                     PVRFAQSMKTLESEGYETFLEIGPRPILLGMGRQCVTEDVGEWLPSLRPGVDEWEQMLS
                     SLGKLYVKGAKIDWSGFDSDYTRQKVVLPTYPFQGERYWVETNNNFWPQRQFSQGENLH
                     PLLGQKLNCAGEQQIFASQIGENSPNYLRDHRVFNQALFPITGYLEIAIAAGNHQLKTS
                     QIVIEDLTITRGWILPTGELTNAQTILTPIDNQSYKFQIFSQPEQQEWRLHTTGKIRKE
                     STPPTQTKVDLEKYKSECNQTIEVKQHYQKCQQVGIDYGNTFQGIQELWSGSNQALGYI
                     KLPEELITQTSDYHFHPALLDAALQVMFYALPATDNDKTYLSAGIEEFRLYKTPGLSIW
                     AYVSVTSQEVETPESLTAIVTIVTPEGEIIANIKGLQVKLATKQTLLGTETESIENWLY
                     EVEWRNKGILGKLLPPDFLIPPIQINQKLTPTLTELVTQVDNETTASFETSLEELSRDY
                     IVQALQSMSWSYKPTESFAFDVAAQKLGIVPTHRPLFKRLLQILTESGILNSKNQQWEV
                     AQTLPEVKPTEKISSLQKKYPEETAALTLLSRCGSKLSGVLRGAIDPGELVFPQGDLTA
                     ATQLYEDSTVAKVMNTIVEKSITKAIEKSPKSRGLRLLEIGGGTGGTTSYILPHLTPQQ
                     TEYTFTDIGALFTAKAQEKFRDYKFIKYQTLDIEVDPTTQGFEAHQYDVIIAANVLHAT
                     TDMKQTLSHVRELLADGGMLVLSEATAKTLWVDLVFGLLEGWWKFRDYELRPDYPLLSR
                     EKWHHVLRETGFTEVVTMPEVEGMAETLSAQTVIVAKSSQTKLEQRNDDSKSWLILADS
                     EGVGQQLATLLRSVGEVCTLVFAGERYQQIAPGEFSINPNQAKDFEEVIETVAGKSPSL
                     YGVVQCWTTEAGVGNGINSEELGSLSKLGCGTTLSLVQALVKGGLSTVPRLWLVTNGAQ
                     AVPNNHPVIPGVAQSSVWGMGKVISWEHPELNCTRIDLDPEETLEGKVDALFKEIWSED
                     REDQVAWRGDSRYVARLVGSHHRQLVAQQADGKTQKPLSFRSEASYLITGGMGGLGLLV
                     ASWMVSKGAKHLILLGRRSPDDATRKKITELEMAGASVVVEKADVTDLESMKGVLQRIE
                     ESKRPLVGVIHSVMVLSNGVLRNQTWSSFEQVMEPKVQGAWHLHQLTQSQPLDFFVLFS
                     SATSLLGSLGQGMANYSAANGFLDGLAHYRRTMGLPGLSIHWGAVSQVGRALGRDTETA
                     AMLSKNGMGLISPAQVLESLELLMSSSDVEVGVMPIEWSGWQERVAQWPFLVDWQETIL
                     EVAQPSKSDFLLKLEATPPNELRLLLVAHVRRQVAQVLRISHPESIEMDTGFFDLGIDS
                     LTSVELRNKLQGSLKCSVPSTVTLDYPTIKALVEYLYQQLLLEQVSYSNTVPTEEINED
                     REEITL"
     aSDomain        24716..25420
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprG_ECH.1"
                     /evalue="1.70E-47"
                     /label="aprG_ECH.1"
                     /locus_tag="aprG"
                     /protein_end="255"
                     /protein_start="20"
                     /score="153.6"
                     /tool="antismash"
                     /translation="VELGNGVVQITMKDEESCNGFSPGIIEGLYKCFGAVAQNQSYKVV
                     ILTGYGNYFCSGGTKERLISIWKGDSKCNDLDFFRIALDCEIPVIAAMQGHSIGGGLVL
                     GLYADLVVLSQESIYTTNFMKYGFTPGVGCTLILPEKFGALGFEMMYTAQNYRGKELAE
                     RGVSFPVVPRKDVLEVAKNIAYEMSEKPRLSLITLKEHLTSKIRKTLPGFIDKEVAMHE
                     ITFHQPEVASRIE"
     aSModule        24716..26503
                     /domains="nrpspksdomains_aprG_ECH.1"
                     /domains="nrpspksdomains_aprG_PKS_ER.1"
                     /incomplete
                     /locus_tags="aprG"
                     /tool="antismash"
                     /type="pks"
     aSDomain        25547..26503
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprG_PKS_ER.1"
                     /evalue="1.30E-98"
                     /label="aprG_PKS_ER.1"
                     /locus_tag="aprG"
                     /protein_end="616"
                     /protein_start="297"
                     /score="321.9"
                     /tool="antismash"
                     /translation="GSLNNLTLVPLERRVPSPSEVEVQIKTVPVNFRDILNALGMLQEY
                     YEKTFGIANAEDLTFGFEGAGTIVAVGAEVSQWQVGDEVMVMRIHDAFSSFIICSPDKL
                     VRKNFNLNMEDGASIWGPFSTAYHGLINLAKIQPGDRVLIHAASGGIGQAAIQLAQLFG
                     AEVFATTSPGKMNYLREQGIKYVMNSRTMEFVNDVMEFTQGRGVDVILNSLTHGEYIQK
                     NLEILADRGRYVELGKLGIWSHEQVYQKRPDIKYFTFDLLEEFAKDNQLFSQIWDNLAL
                     EFDRDRLKPLPYKTFPIEDVLKAFDYMRRGKHFGRVVV"
     CDS_motif       25961..26023
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0001"
                     /evalue="2.20E-10"
                     /label="PKSI-ER_m5"
                     /locus_tag="aprG"
                     /protein_end="456"
                     /protein_start="435"
                     /score="32.7"
                     /tool="antismash"
                     /translation="GDRVLIHAASGGIGQAAIQLA"
     CDS_motif       26150..26188
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0002"
                     /evalue="3.20E-05"
                     /label="PKSI-ER_m7"
                     /locus_tag="aprG"
                     /protein_end="511"
                     /protein_start="498"
                     /score="16.3"
                     /tool="antismash"
                     /translation="TQGRGVDVILNSL"
     CDS_motif       26456..26503
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0003"
                     /evalue="1.10E-03"
                     /label="PKSI-ER_m9"
                     /locus_tag="aprG"
                     /protein_end="616"
                     /protein_start="600"
                     /score="12.2"
                     /tool="antismash"
                     /translation="AFDYMRRGKHFGRVVV"
     aSDomain        26882..28159
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprG_PKS_KS.1"
                     /domain_subtypes="Trans-AT-KS"
                     /evalue="2.00E-170"
                     /label="aprG_PKS_KS.1"
                     /locus_tag="aprG"
                     /protein_end="1168"
                     /protein_start="742"
                     /score="559.2"
                     /specificity="transATor: (unknown)"
                     /tool="antismash"
                     /translation="IAIIGISCRYPGANNWKEFWENLKNGIDSVTEAPPGRWEEKNWYH
                     PDPDNPGTSYSKCAGFLDEIDKFDPLFFHISPEEAWFMEPEQRIFLEEAYHAIEDAGYA
                     TDSLRGKQYGVFVGVTVNGGYLKLLSISGLDVHRMAATGNGPSMIPARIAYMLDLQGPV
                     VAIDTACSSSLVAVHQACQSIQRGESEIAIAGGITLMPTSDFQIMSSQFQVVSPDGRCK
                     TFDASASGTAWSEGCGVLLLKSYSQAIQDNDHIYGVIKGTGVNYDGNTNGISAPSSQSQ
                     ASLEEAVYQKFGINPETISYVEAHGTATPLGDPIEVEALTEAFSKWTNKKQFCAIGSVK
                     TNIGHSAAAAGVSGLIKTILCLKNQKLVPSLHFNQPNPHIDFENSPFYVNTKLKDWEVL
                     EGQPRQATVSSFGFSGTNAHIVIEEAP"
     aSModule        26882..33406
                     /complete
                     /domains="nrpspksdomains_aprG_PKS_KS.1"
                     /domains="nrpspksdomains_aprG_PKS_AT.1"
                     /domains="nrpspksdomains_aprG_PKS_DH2.1"
                     /domains="nrpspksdomains_aprG_cMT.1"
                     /domains="nrpspksdomains_aprG_PKS_KR.1"
                     /domains="nrpspksdomains_aprG_PKS_PP.1"
                     /locus_tags="aprG"
                     /monomer_pairings="mal -> Me-ccmal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       27362..27409
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0004"
                     /evalue="6.90E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="aprG"
                     /protein_end="918"
                     /protein_start="902"
                     /score="18.1"
                     /tool="antismash"
                     /translation="GPVVAIDTACSSSLVA"
     CDS_motif       27782..27829
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0005"
                     /evalue="1.60E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="aprG"
                     /protein_end="1058"
                     /protein_start="1042"
                     /score="11.0"
                     /tool="antismash"
                     /translation="YVEAHGTATPLGDPIE"
     CDS_motif       27890..27934
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0006"
                     /evalue="6.40E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="aprG"
                     /protein_end="1093"
                     /protein_start="1078"
                     /score="9.4"
                     /tool="antismash"
                     /translation="GSVKTNIGHSAAAAG"
     aSDomain        28469..29362
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprG_PKS_AT.1"
                     /evalue="7.60E-118"
                     /label="aprG_PKS_AT.1"
                     /locus_tag="aprG"
                     /protein_end="1569"
                     /protein_start="1271"
                     /score="385.0"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFTGQGSQYANMGRQLYEKAPTFRQALEECDQILQPYLEVPLLEV
                     IYSEDAQKSSDNLLDQTAYTQPAVFAVEYALAKLWSSWGIKPCVVMGHSVGEYVAATVA
                     GVFSLEDGLKLIAMRGKLMQKLPSGGEMVSVMASESQVTEAIKEYSSQVTIAAINGPES
                     IVISGESVAIKNICSLFESEGIKTKQLQVSHAFHSPMMEPMLAEFESVAKQVTYNQPQI
                     PLISNVTGTEVDGEITNAEYWVDHVRQPVRFAQSMKTLESEGYETFLEIGPRPILLGMG
                     RQCVTEDVGEWLPSLRP"
     CDS_motif       28472..28519
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0007"
                     /evalue="2.20E-06"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="aprG"
                     /protein_end="1288"
                     /protein_start="1272"
                     /score="20.0"
                     /tool="antismash"
                     /translation="FTGQGSQYANMGRQLY"
     CDS_motif       28649..28714
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0008"
                     /evalue="1.50E-04"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="aprG"
                     /protein_end="1353"
                     /protein_start="1331"
                     /score="14.9"
                     /tool="antismash"
                     /translation="QTAYTQPAVFAVEYALAKLWSS"
     CDS_motif       28718..28840
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0009"
                     /evalue="1.50E-26"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="aprG"
                     /protein_end="1395"
                     /protein_start="1354"
                     /score="84.8"
                     /tool="antismash"
                     /translation="GIKPCVVMGHSVGEYVAATVAGVFSLEDGLKLIAMRGKLMQ"
     CDS_motif       28934..28972
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0010"
                     /evalue="4.60E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="aprG"
                     /protein_end="1439"
                     /protein_start="1426"
                     /score="13.4"
                     /tool="antismash"
                     /translation="AAINGPESIVISG"
     CDS_motif       29126..29158
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0011"
                     /evalue="3.30E-03"
                     /label="PKSI-AT-M_m7"
                     /locus_tag="aprG"
                     /protein_end="1501"
                     /protein_start="1490"
                     /score="10.2"
                     /tool="antismash"
                     /translation="PQIPLISNVTG"
     CDS_motif       29192..29227
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0012"
                     /evalue="7.60E-05"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="aprG"
                     /protein_end="1524"
                     /protein_start="1512"
                     /score="16.0"
                     /tool="antismash"
                     /translation="YWVDHVRQPVRF"
     CDS_motif       29648..29725
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0013"
                     /evalue="2.00E-09"
                     /label="PKSI-DH_m2"
                     /locus_tag="aprG"
                     /protein_end="1690"
                     /protein_start="1664"
                     /score="29.9"
                     /tool="antismash"
                     /translation="YLRDHRVFNQALFPITGYLEIAIAAG"
     aSDomain        29648..30286
                     /aSDomain="PKS_DH2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprG_PKS_DH2.1"
                     /evalue="5.00E-38"
                     /label="aprG_PKS_DH2.1"
                     /locus_tag="aprG"
                     /protein_end="1877"
                     /protein_start="1664"
                     /score="122.6"
                     /tool="antismash"
                     /translation="YLRDHRVFNQALFPITGYLEIAIAAGNHQLKTSQIVIEDLTITRG
                     WILPTGELTNAQTILTPIDNQSYKFQIFSQPEQQEWRLHTTGKIRKESTPPTQTKVDLE
                     KYKSECNQTIEVKQHYQKCQQVGIDYGNTFQGIQELWSGSNQALGYIKLPEELITQTSD
                     YHFHPALLDAALQVMFYALPATDNDKTYLSAGIEEFRLYKTPGLSIWAYV"
     aSDomain        30989..31624
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprG_cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="3.80E-113"
                     /label="aprG_cMT.1"
                     /locus_tag="aprG"
                     /protein_end="2323"
                     /protein_start="2111"
                     /score="369.9"
                     /tool="antismash"
                     /translation="TQLYEDSTVAKVMNTIVEKSITKAIEKSPKSRGLRLLEIGGGTGG
                     TTSYILPHLTPQQTEYTFTDIGALFTAKAQEKFRDYKFIKYQTLDIEVDPTTQGFEAHQ
                     YDVIIAANVLHATTDMKQTLSHVRELLADGGMLVLSEATAKTLWVDLVFGLLEGWWKFR
                     DYELRPDYPLLSREKWHHVLRETGFTEVVTMPEVEGMAETLSAQTVIVA"
     CDS_motif       32357..32455
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0014"
                     /evalue="1.30E-16"
                     /label="PKSI-KR_m1"
                     /locus_tag="aprG"
                     /protein_end="2600"
                     /protein_start="2567"
                     /score="53.1"
                     /tool="antismash"
                     /translation="SYLITGGMGGLGLLVASWMVSKGAKHLILLGRR"
     aSDomain        32357..32890
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprG_PKS_KR.1"
                     /evalue="2.30E-62"
                     /label="aprG_PKS_KR.1"
                     /locus_tag="aprG"
                     /protein_end="2745"
                     /protein_start="2567"
                     /score="202.0"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="SYLITGGMGGLGLLVASWMVSKGAKHLILLGRRSPDDATRKKITE
                     LEMAGASVVVEKADVTDLESMKGVLQRIEESKRPLVGVIHSVMVLSNGVLRNQTWSSFE
                     QVMEPKVQGAWHLHQLTQSQPLDFFVLFSSATSLLGSLGQGMANYSAANGFLDGLAHYR
                     RTMGLPGLSIHWGAV"
     CDS_motif       32681..32710
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0015"
                     /evalue="1.60E-03"
                     /label="PKSI-KR_m3"
                     /locus_tag="aprG"
                     /protein_end="2685"
                     /protein_start="2675"
                     /score="11.9"
                     /tool="antismash"
                     /translation="PKVQGAWHLH"
     CDS_motif       32732..32848
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprG_0016"
                     /evalue="9.00E-18"
                     /label="PKSI-KR_m4"
                     /locus_tag="aprG"
                     /protein_end="2731"
                     /protein_start="2692"
                     /score="56.8"
                     /tool="antismash"
                     /translation="LDFFVLFSSATSLLGSLGQGMANYSAANGFLDGLAHYRR"
     aSDomain        33149..33406
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprG_PKS_PP.1"
                     /evalue="2.10E-23"
                     /label="aprG_PKS_PP.1"
                     /locus_tag="aprG"
                     /protein_end="2917"
                     /protein_start="2831"
                     /score="74.4"
                     /tool="antismash"
                     /translation="LEATPPNELRLLLVAHVRRQVAQVLRISHPESIEMDTGFFDLGID
                     SLTSVELRNKLQGSLKCSVPSTVTLDYPTIKALVEYLYQQL"
     gene            33481..37011
                     /gene="aprH"
     CDS             33481..37011
                     /NRPS_PKS="Domain: Heterocyclization (75-373). E-value:
                     4.3e-103. Score: 336.7. Matches aSDomain:
                     nrpspksdomains_aprH_Heterocyclization.1"
                     /NRPS_PKS="Domain: AMP-binding (544-943). E-value:
                     1.4e-102. Score: 335.2. Matches aSDomain:
                     nrpspksdomains_aprH_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1072-1140). E-value: 4.5e-23.
                     Score: 73.1. Matches aSDomain: nrpspksdomains_aprH_PCP.1"
                     /codon_start=1
                     /gene="aprH"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     155.2; E-value: 5.2e-47)"
                     /gene_kind="biosynthetic"
                     /product="non-ribosomal peptide synthatase"
                     /protein_id="QBM78313.1"
                     /sec_met_domain="Condensation (E-value: 7.7e-48, bitscore:
                     152.6, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-114, bitscore:
                     372.7, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.5e-15, bitscore:
                     45.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLTEILSQISSQNIKLWTEGDELKISAPKGTLTKEIRDLLSQNK
                     LELVSLLRQKSSNITATSSWPTLIPAPEERYQPFPLNAIQQAYWIGRNGFFNLGNIATH
                     VYIELDCENLNLERVNQAWRQLIEHNEMMRMVVLADGNQQILEQVPPYEIEVLDLSGES
                     PQTIASELENIRNQMSHQVLPTNQWPLFDLRAARLNEQWCRLYIDIDMLILDGLSFYML
                     FEQWAQLYKEPESELPATEISFRDYVLAELALKDSPQYLRSQQYWFNRLDELPPAPEMP
                     QAKITSAITNPRFKTHTAGLSTTNWQQLKHKARKADLSPSGVLLSAFAYILNYWSKSPK
                     FTINLTIFNRLPLHPQVNELLGDFTSNILLAVDHSQAVPFISRAQKLQKLLWVDLEHRY
                     INGVEVQRELHRRGRSQPMGVVFTSMLGFEYLVDERLGRRLGLDEFGEEVYKVGTTPQV
                     WLDNVVAEKNGALIFNWYAVEALFPEGLIDKMFEAYCDLLQQLATSDEPWMETYFQLLP
                     TAQLALQAQVNQTTQSLPEGLLHGLFVEKVKVQGQEIAVISPQKSLTYEELYQRSHQLG
                     DGLRKLEVKPNELVAVVMEKGWEQVVGVLGILMSGGAYLPIDPALPQERQWYLLEQAEV
                     KQVLTQTHLKQSLSWPEGINCWSVDSEELAVENPTPLEPVQTPEDLAYVIYTSGSTGLP
                     KGVMIDHRGAVNTILDINQRFEVRASDRVLALANLNFDLSVYDIFGVLGAGGTIVMPPP
                     EAAKDPACWIELIETHQVTLWNSVPPLMQMLVEHLFGTSRVPVEGLRVVMLSGDWLPVD
                     LPEKIQSLWPNVQVMSLGGATEASIWSIGYKIEKVDPNWKSIPYGKPLLNQRFYVLNEL
                     MEARPVWVPGQLYIGGVGLAKGYWKNEEKTKASFITHPVTQERLYKTGDLGRYLPDGNI
                     EFLGREDFQVKINGYRVELGEIEAALKPFPGMKEAIVTTIGDSEQNKRLIAYAVLKQQP
                     ITTENQIEEQDKISQLDQELNSCSQQLRKYLRQKLPEYMIPSKYVILEAFPLTANGKID
                     RKRLPEPQVETMTTTEYILPQTKIEQQIAAVWREVLQMEKVGIHDNLFDIGGNSVHAIR
                     VHSKLQELLGIELKVVDLFTNPTVNSLSQYLDQIDRSSGTIKNRGDERSKKGIARKKRG
                     NFRKSIRHKK"
     aSDomain        33706..34599
                     /aSDomain="Heterocyclization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprH_Heterocyclization.1"
                     /evalue="4.30E-103"
                     /label="aprH_Heterocyclization.1"
                     /locus_tag="aprH"
                     /protein_end="373"
                     /protein_start="75"
                     /score="336.7"
                     /tool="antismash"
                     /translation="YQPFPLNAIQQAYWIGRNGFFNLGNIATHVYIELDCENLNLERVN
                     QAWRQLIEHNEMMRMVVLADGNQQILEQVPPYEIEVLDLSGESPQTIASELENIRNQMS
                     HQVLPTNQWPLFDLRAARLNEQWCRLYIDIDMLILDGLSFYMLFEQWAQLYKEPESELP
                     ATEISFRDYVLAELALKDSPQYLRSQQYWFNRLDELPPAPEMPQAKITSAITNPRFKTH
                     TAGLSTTNWQQLKHKARKADLSPSGVLLSAFAYILNYWSKSPKFTINLTIFNRLPLHPQ
                     VNELLGDFTSNILLAVD"
     aSModule        33706..36900
                     /complete
                     /domains="nrpspksdomains_aprH_Heterocyclization.1"
                     /domains="nrpspksdomains_aprH_AMP-binding.1"
                     /domains="nrpspksdomains_aprH_PCP.1"
                     /locus_tags="aprH"
                     /monomer_pairings="Cys -> Cys"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       33730..33756
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprH_0001"
                     /evalue="4.10E-03"
                     /label="Cy1"
                     /locus_tag="aprH"
                     /protein_end="92"
                     /protein_start="83"
                     /score="9.9"
                     /tool="antismash"
                     /translation="IQQAYWIGR"
     CDS_motif       33856..33909
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprH_0002"
                     /evalue="1.90E-04"
                     /label="Cy2"
                     /locus_tag="aprH"
                     /protein_end="143"
                     /protein_start="125"
                     /score="14.0"
                     /tool="antismash"
                     /translation="LIEHNEMMRMVVLADGNQ"
     CDS_motif       34090..34134
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprH_0003"
                     /evalue="4.20E-04"
                     /label="Cy3"
                     /locus_tag="aprH"
                     /protein_end="218"
                     /protein_start="203"
                     /score="13.6"
                     /tool="antismash"
                     /translation="RLYIDIDMLILDGLS"
     CDS_motif       34432..34488
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprH_0004"
                     /evalue="5.80E-06"
                     /label="Cy4"
                     /locus_tag="aprH"
                     /protein_end="336"
                     /protein_start="317"
                     /score="19.2"
                     /tool="antismash"
                     /translation="LSPSGVLLSAFAYILNYWS"
     CDS_motif       34501..34539
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprH_0005"
                     /evalue="2.10E-04"
                     /label="afterCy4"
                     /locus_tag="aprH"
                     /protein_end="353"
                     /protein_start="340"
                     /score="13.9"
                     /tool="antismash"
                     /translation="FTINLTIFNRLPL"
     CDS_motif       34540..34599
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprH_0006"
                     /evalue="5.10E-09"
                     /label="Cy5"
                     /locus_tag="aprH"
                     /protein_end="373"
                     /protein_start="353"
                     /score="28.2"
                     /tool="antismash"
                     /translation="HPQVNELLGDFTSNILLAVD"
     CDS_motif       34660..34707
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprH_0007"
                     /evalue="4.20E-05"
                     /label="afterCy5"
                     /locus_tag="aprH"
                     /protein_end="409"
                     /protein_start="393"
                     /score="16.2"
                     /tool="antismash"
                     /translation="DLEHRYINGVEVQREL"
     CDS_motif       34840..34881
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprH_0008"
                     /evalue="1.40E-04"
                     /label="Cy7"
                     /locus_tag="aprH"
                     /protein_end="467"
                     /protein_start="453"
                     /score="14.9"
                     /tool="antismash"
                     /translation="TTPQVWLDNVVAEK"
     CDS_motif       34924..34953
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprH_0009"
                     /evalue="1.40E-02"
                     /label="afterCy7"
                     /locus_tag="aprH"
                     /protein_end="491"
                     /protein_start="481"
                     /score="8.9"
                     /tool="antismash"
                     /translation="FPEGLIDKMF"
     aSDomain        35113..36309
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprH_AMP-binding.1"
                     /evalue="1.40E-102"
                     /label="aprH_AMP-binding.1"
                     /locus_tag="aprH"
                     /protein_end="943"
                     /protein_start="544"
                     /score="335.2"
                     /specificity="substrate consensus: Cys"
                     /tool="antismash"
                     /translation="EKVKVQGQEIAVISPQKSLTYEELYQRSHQLGDGLRKLEVKPNEL
                     VAVVMEKGWEQVVGVLGILMSGGAYLPIDPALPQERQWYLLEQAEVKQVLTQTHLKQSL
                     SWPEGINCWSVDSEELAVENPTPLEPVQTPEDLAYVIYTSGSTGLPKGVMIDHRGAVNT
                     ILDINQRFEVRASDRVLALANLNFDLSVYDIFGVLGAGGTIVMPPPEAAKDPACWIELI
                     ETHQVTLWNSVPPLMQMLVEHLFGTSRVPVEGLRVVMLSGDWLPVDLPEKIQSLWPNVQ
                     VMSLGGATEASIWSIGYKIEKVDPNWKSIPYGKPLLNQRFYVLNELMEARPVWVPGQLY
                     IGGVGLAKGYWKNEEKTKASFITHPVTQERLYKTGDLGRYLPDGNIEFLGREDFQVKIN
                     "
     CDS_motif       35293..35334
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprH_0010"
                     /evalue="9.50E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="aprH"
                     /protein_end="618"
                     /protein_start="604"
                     /score="12.7"
                     /tool="antismash"
                     /translation="LGILMSGGAYLPID"
     CDS_motif       35524..35583
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprH_0011"
                     /evalue="1.50E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="aprH"
                     /protein_end="701"
                     /protein_start="681"
                     /score="32.9"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGLPKGVMIDH"
     CDS_motif       35695..35727
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprH_0012"
                     /evalue="2.80E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="aprH"
                     /protein_end="749"
                     /protein_start="738"
                     /score="-0.7"
                     /tool="antismash"
                     /translation="FGVLGAGGTIV"
     CDS_motif       36106..36195
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprH_0013"
                     /evalue="4.00E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="aprH"
                     /protein_end="905"
                     /protein_start="875"
                     /score="41.5"
                     /tool="antismash"
                     /translation="PVWVPGQLYIGGVGLAKGYWKNEEKTKASF"
     CDS_motif       36274..36339
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprH_0014"
                     /evalue="1.30E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="aprH"
                     /protein_end="953"
                     /protein_start="931"
                     /score="36.4"
                     /tool="antismash"
                     /translation="FLGREDFQVKINGYRVELGEIE"
     CDS_motif       36634..36660
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aprH_0015"
                     /evalue="7.00E+01"
                     /label="afterCy7"
                     /locus_tag="aprH"
                     /protein_end="1060"
                     /protein_start="1051"
                     /score="-1.9"
                     /tool="antismash"
                     /translation="LPEPQVETM"
     aSDomain        36697..36900
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aprH_PCP.1"
                     /evalue="4.50E-23"
                     /label="aprH_PCP.1"
                     /locus_tag="aprH"
                     /protein_end="1140"
                     /protein_start="1072"
                     /score="73.1"
                     /tool="antismash"
                     /translation="EQQIAAVWREVLQMEKVGIHDNLFDIGGNSVHAIRVHSKLQELLG
                     IELKVVDLFTNPTVNSLSQYLDQ"
     gene            37318..>37851
                     /gene="aprI"
     misc_feature    37318..>37851
                     /gene="aprI"
                     /note="similar to polyketide synthase"
ORIGIN
        1 gtcaacagta aactgaattt atccggaaac cttaatcccc tgctcaatcc tggtgctatt
       61 gctaccatta aagcaaatac catatcgcta gagttgccaa aacactcctt taatgctaaa
      121 ggagtaatcc tactatccca tctcaccaaa actaatccta gtcagatgcc atgggagatt
      181 ggaactgatc taaacctgga ggttggttct gatctcagta aattacccta taacctgcta
      241 ttgagtcggt tacctttgga gcaaatttcc ccagggtatc aaattcaggt caacggtcaa
      301 gctgacttga acggtcgcat ccaagggaaa aatttactat cagctccctt gctacctggg
      361 aatttgaatc tgaccgggaa tctacagcta tcgaatttga aggttaacga cttaaccttt
      421 gagccagtgt tagctgggcc agtaaccgtt gcgccaggac aagaattagc catagattta
      481 cgaggaaaga aagatggaaa cagcctagga acaccaaccc tgtacaagag gagaccaatg
      541 tcttgctccc tacctgcccg catcctttac actccaacag ggacaagggt cacaattccc
      601 gattctgatc acaggagtac gccggggaga taacttaacc gctcaaatca agaatttttc
      661 cctagctagc cttaatctta ggcctggttt aagctacggt attcccggta gattggaagg
      721 tgaagtaaca gggcaagcca accttaatct tttcacccta gaaacttctg gtcgtaatac
      781 tatcgacatt aagcaacttg ctctaggaga aatcaacgct aaacaagtta gtgctaactt
      841 ctcctatcaa aatgacattg cccagatcgc atcagctgct ttaatcttag gcaacagtcg
      901 atatttattc aaaaatggtc gatttaatct caagtctcaa cagataaacg gcaagcttac
      961 tattccagaa gcttatattg aagacctact gactattgtc aaacgtgttg atattatcga
     1021 catcgcccaa agattccaaa ctactaattc ttctattact aattcctcta gtgataacat
     1081 tggcaacaat aaatctggca acgctgacca attacgacca ttccctagta tagcagcagg
     1141 ctccctagcc actctcctac aacggtttgc caaaattaat gcccaaaacg acgctgttgc
     1201 taaccccttc gatcctaata cactcctcac taattttgat attcgaggta agtatactgg
     1261 taaaattgct gttgctggta tcttgactaa tcctaaagtc aattttaatg tcgagggcaa
     1321 caactggcag tggtatgcta attcccccaa tcaagttatt gtgatcaacc aattggttgc
     1381 taaaggaagt tacgaccaag gtctaattac tgtgcagcca gcccgaatgg aattgggcga
     1441 aacagtctta gcatttcaag gaaagcttgc ccaagaaacc aactcaggag acttcctcct
     1501 ccagaattta tctctagagg ccgttagcaa cttagcaagc aattttgtca ctattccctt
     1561 tgagattgca ggtaacttaa atgccaaagg ccaactgggt ggtagtctca ccaatcccga
     1621 agtcaccaac gggcaagtcg cttttgtaga tggctccgtg aatgatacct cccttgatga
     1681 tgttgaagtg actttcgact atgttgattc tcgtcttgac tttgatacca acaaaccaga
     1741 ttatctacaa gcctctggta aagttccctt tcctcccaaa ccagatagcg atcgcataga
     1801 tatcaacctc aagctagcaa ctccagccat ggcactcgtg agtgtagtga ctcaagaaca
     1861 agtggcatgg gtgaatggag aggatagaac tgctgatata gaactggatg ttagtggacg
     1921 tttggagtta gcagatagta tcaaaattaa agacttatca ggaacatctg aggttaatat
     1981 ccagaatggc actatcaaaa ctaagttgtt agaggatgac tttactctca atgttgtagg
     2041 caagtttaag ttagatgatc aacgcctgca agtagtaaac tatccagata cagaaggtca
     2101 aaaaactatc gaaggtgacc tagccgggat tggattttcc gtgtctgggg aattgccgat
     2161 agtgtcaaat agaacaaaca cctccaatcc cctaaccctg aaaatcccta aagataacct
     2221 aaaattagca gggctttatg aaggtggagt aggcggtaat gtcgtgatta cgggttcagc
     2281 attgcgtcca gttattgcag gaaacattag cttagaaaat ggccaagcct ttatacccaa
     2341 ggcacaagaa accaagaccg aggaaagtga cgaaaaaacc gttaagaata cgtctaatca
     2401 gactccctca gtagttcgta gtcgcaacaa taatcagttt gtgcctaggt taaagaattt
     2461 tcaggtgagt ttgggagatg agttaagagt gcaacagttt cccctatatg attttcgact
     2521 agctggtgat ttaaccctca acggtcctat caatggcaat ctccaaaact taacaggatt
     2581 gggaacaatt aagctacgac gtggggaagt tgatgtatta gaaaccgaat ttgttgcaga
     2641 caggcggcac aataacacta ttgtgtttgt accagaacaa ggattactca atcccaattt
     2701 agatcttaaa tttaccacca tagcctttga gccttctggt gccttacgtc aaagacggat
     2761 tgataacgaa atccttgaga atgtgctgca gtcttctcga cccgaccaag taaagataac
     2821 cctcgcgatc aaaggtcaaa ctagtcaaat tcttgcccta ggaggagaga aagattattg
     2881 tgctgatcag caaattacca gtagtggact agctaaactt ggttcaaaaa caaccatctt
     2941 gtctcgccaa caattccaag agcttgctga atgtgtttat ggcgaagcta ttgctaatag
     3001 tgaagacaag gagtttctat tttcccccat tgtcacctta agcagtactc ctccccgcag
     3061 tgaaagtgga attatcgctc tgctcggtaa cagttttatt acccaatttc agactatcgc
     3121 taacagcaac gaacgagaaa tagctgagtt agtgattact cagtatgttg ttcgaccaat
     3181 tatcaaaaat attttattca ccgttgaaga aaaagtcagt aatgtcggga gatccatcgg
     3241 attagctgat ctacaggttt acccaacctt cgatgccgtt tatgatttgg gacaaacttc
     3301 ctcagttgaa ttgagttacg actacgtgtt taatgaggta caagttagat ataaattgca
     3361 attttgatta gctataattt agaatttaaa atttataatt tagagtgcgt agggtgtgtt
     3421 aggggcggac ttgccctcat tttccgcctc gtaaccagtg ttgcaatagt ccgccccgta
     3481 acgcaccacc gggtcaaaca gttgaaatag tctattatcc cagggtaatc gcatcttaat
     3541 tttgtataaa atgtacttga caaatagtta ggtgtgtggg tctacctccc agaagcccaa
     3601 gcagttaacc tgaggatcaa caaaagtttc tatttcccca tcgttggtca tgtcaaaagg
     3661 caatggccgc acttgtgctg acacctcagc aacaacaaca ggcattgatt cttagaaaga
     3721 gtgttcttaa acactttcaa cacctacagg atccccgtgt ggaaagaacc cagcatcaca
     3781 gtttgctagg gatagtcacc attgccattt tggctatcct ctctggagcc gatgggtttg
     3841 tcgccattga gacctacggc aaagccaagc ttgggtggct agagaccttt ttggacttac
     3901 cctatgggat tccctcccat gatacctttg gccgggtgtt gggtcgcctc gaaccccaag
     3961 agctagaaac cagtttcctg agttgggtca gcagcatcac cgagaaatta ggtgtgagac
     4021 tgattcatat cgatggcaag aggctaaaag gttcttatga ccgagaaagc caacttaaag
     4081 ctctgcacag tgtcagtgcc tggagcagtg aacatgggct ggtgctggct cagcaaaagg
     4141 tcgagagcaa gtccaatgaa atcaaggcag tacctctgct gctgaagttg cttaacctta
     4201 agggagctgt agtgaccctc gatgcgatgg gaacccaaat ctccatcgct gggcaaatca
     4261 agaaggccga aggagactat gttttggctc tcaaaggcaa ccaaggtcag ctcagccagt
     4321 cagtaaagga ttggtttaag caagctcaag ctcagaactg gcaggggatt gagttcactc
     4381 accatcagag tatcgaaagt gggcatcacc gcagggatac tcgtcaggtt tgggcggtgc
     4441 cagtgagtca attaccgccg ttgcatcggc aacccgagtg gataggctta accaccgtag
     4501 tgatggttaa gactacgcga gagttatgga acaaaactac caaggaagtt cgcttttaca
     4561 ttagtagtct cgaagcggat gctcagggcc ataaccaggt cattcgctcc cattggacta
     4621 ttgaaaatag tctgcattgg gtgctagatg tcaccttcaa cgaagatgcg agtcggattc
     4681 gtcagggtta tgctgcccaa aacctggggc tgttgcgccg tttaagtgtc aatttactca
     4741 agcgcgaacc gtcccgactc agtctgaaga tgaagcgtta caaggccggg atggacaatg
     4801 actttgtgat caaaattctg gcagccagtg gggctgagtg aggggttccc tcaggtcaag
     4861 gcaagtttga ggacaacttt gatcaggtca tggacttctt catatagctc aagccacata
     4921 tccaaagcac tttgcgggac ttgaacacta aatacatcag ctttgtgcat gtcataactt
     4981 gcagtgtaca gtcaaattaa tggtcaagtt agagtaattt tagaactgga ttaagatgcg
     5041 attaccctgt ctattatccc tattccctat tccctgttcc ctgttccctg tgccctgttc
     5101 cctttcttat actatttttt caaaatacta caaataagtt cccctggacc gttctgttga
     5161 aatggcacaa cagttctgtc tttcttaact ctaatgcgat cgcgacaatt atatatttct
     5221 ataggagtag caacgccatt aacactaact gatgctcgat attcccatgg atacttagca
     5281 ctccgcttga tgctaaggat gcaaatccgg ttgttatttt tagtgcggca gtaggagaaa
     5341 gcaacagcgg gaggagcaaa ggcaaaggat aatgttagca acagcaataa cgtagttagg
     5401 tattttttca tttttgaaag ttgttattgg agagaatcgg gaatcgggaa tcgggaatcg
     5461 ggaatcggga atcgggaatc gggaataaaa tttagattta cctgactaga ctaggaaacg
     5521 ctagattata gtttcaaaga tagattgttg cacaacttgg aaaaaatata aagagatcta
     5581 ggttacgtaa ataaattttg ataattgttg ttctctgttt cctgctccga agcgggtgca
     5641 tatcattaaa gctgtttgac ctggtgggtg gaacgggcat cttgcccgtg gtgcgttacg
     5701 gtgcgggctg tttcaacaag gcgcgaagag gggaaaaatt aaggctcgcc cgcccctaac
     5761 gcaccctacg aactgatagc tgatagcnga taaccttcaa ccatctaacc ttcaaccann
     5821 taaccttcaa ccatctaacc ttcaaccatc taaccttcaa ccatctaacc ttnaacctnc
     5881 taaccnnnaa aaagtagccg cagaactatg ttccacggct acgaattgtt acttatgtct
     5941 caactttgta aacccatccg gacgtgatcc gatgtgattg gcctttggcc agggggggga
     6001 aaccccccca aaatttaagc ccttaaccca gagttaagta tttcgtcatt accgtgatga
     6061 attccccagg aatctcagtt gcctgaaggg ggctccattc gtcaatttgg gcgtaacccc
     6121 gtgcataaag ggtatacatg gtgttgttta ttgcctggcg agagcctttc aaaatgtgct
     6181 taatggggta ttttttgcgg aaaggttcct gaggagtatt actaggagtg atatcctcag
     6241 gattgttttc tggattaggg cgaaaattgt cagacatagt taacaattcg ttgttaagtt
     6301 tataaatata atcataacga taatagttaa atttgtcaag gggttttata attttttttc
     6361 ggaggggtaa ttgaaataaa atgtacggtt atggaatggg atattgtttt ttaagggagt
     6421 agggaatcgg gaatcgggaa tcgggaatcg ggaatcggga acaaattaca gaatcaaaat
     6481 gttagcgtgc gcgtggcatt tttttcagag aatcgaattt cttggttctt cagtacctgc
     6541 tatgctaaat ttcaggtaaa aaaaacagaa aacttactct acaagcgatg cagcgcggtc
     6601 ttggggagcc agtgcggtct tggggaggca gcgcggtctt gggggtttcc cccatgagcg
     6661 actgccgtgg tctcccccat gagaaactgg cgtggtttcc cccactcgcg ctttgcatca
     6721 agacaggatt ctgaggctat ttacttaaca agtatttcta aatactgcct ctttccactg
     6781 ctccctgctc cctgctccct tcgtcaaatt gttaagttaa aataacaagt acggaagagc
     6841 taaaaaaaat catttcatta aacaagaaag ccaaatttgg actcagttac aacagttagg
     6901 gttaaagcca ggaatagctt tttatcttcg ttcgcgtttg gcctacggcc acgcggggct
     6961 cgttcgcgca gcggaggcct acggcctaaa gcgtcgccta cggcgaggta taaaaattac
     7021 taaaaccaaa caagtagtag gatttgattt ggcaactaaa gaactatgac tctgattcag
     7081 tctaccttct agcttccttg tcaccccatc agcattattt ttttgaccac aagtcgctct
     7141 aattgccaat ccataaggct tctggcttgg ttgtcacccc gtcaggctgc tttaaggcag
     7201 gatgcagaag gcagaaggca cgtaataccg tagttgcaac tattgttaat aattccagtg
     7261 attttacaaa tgatttaaga ttactatatg ttacaagttg gctcttccgg ctttgcggtg
     7321 ataagacaag cttatgtcag gtaattccgc cagttccagc cacgttgatt ttcgattttg
     7381 tgccttttaa tacgttttca accacagatc cggaagagcc tacaagtttt gtcccttgat
     7441 agctataaag gatactgttt tgatactttt gtcaagtacc ttttttacta aattagatga
     7501 gcttaccctg gtaaaattta gtcataagct tattgattgt aaacaataat taatgaaaat
     7561 taatcctaat gaataggagt gttttatacg aaaaatgaga gctatatccc ttgtcatgtc
     7621 tgctttataa ctattttcgt acaaaaaaaa aaaaaaagtg ttgactttct caaataataa
     7681 cgataagata ccaaaagtta ttaagcagcc tatctatata tagcgttcgt catagctatg
     7741 aggtacacat tttttttgcc ctcttccctt atcctggctc ccggctcccc gctccccgct
     7801 ccccgctccc cgctccccgc tcccggctcc ctagaaccca gagagttgta cctcatgggt
     7861 ataagacttg ctatagtatg ctagtctact ctcaaaacac acagatgaga tccatcacaa
     7921 caaagctcaa acttaataac aaacagaaaa agatgatggc tcaacacgca ggagcagatg
     7981 gtgttttaac tggagtttca atttatggaa tatcgagatt taaacccaat tataaggatc
     8041 caaaaatacg gttgtcttga ctttaatgcc tgtgggtgag taaccgccga cggtctcagg
     8101 gtcagcagta attaaacatg atcagatggt cacgttatgt gacgctttgt atcagttttg
     8161 tagagcagtg tagaggtaat agagaaactt agttctaacg aattagatta aaatccgttt
     8221 tagaggagcc actgtcaagg attgtactgt aatgaagagc cgtatgatac gtgcattgtc
     8281 acgtacggtt ctggagacga atcagtggag tgactcactg gcttagttta atggaaactg
     8341 cctgcgggta tccagatcag aagtggtatt aaaagcaaaa aatataataa ataattggta
     8401 taaaaaaaat gctggagtta attaatcgtt atcaatatgg gtttgtttct attcctgtaa
     8461 tcttagcctg tagagaaaag ggattatttg acttaataaa acaaaagaga ataacccacc
     8521 ggcaaatagc taatactcta ggggcaaata cgggtcattt gcaagtagcc ttaaaaatga
     8581 tggaatccct aggttggcta tcaaaaaatg aggttgatga atactccctc acggataatt
     8641 ttcaaccata tctctggaca tgatcaagca tgctattcgg ttgttgctcg actattacct
     8701 acatttccag gatgttccgg ttccaatcag attcatccca taattcagga atgcctactt
     8761 tataaatcag ctctaaaata aaattaaatc aatgctagat aaaataaatc gttatgctca
     8821 tgggtttgta gctgtaccag tgatttgtgc ttgttcagaa gcaggggtat tcgagttact
     8881 atcacagaaa aaatcactga aattagaaga aatagtagag catttagcag caaatagtgg
     8941 acatctaatg gtagctatgc gactcctaga gtcattatca ttcctatatc gctctcaagc
     9001 agaagaatac atattgacag aacaaagtca acaacatcaa atcatcccta aagctctgat
     9061 gagcttatat aaatatccat ttgagttata tttaaaagga gaagtagaaa caggaatcag
     9121 caattggatt aattgttcat ctcgaagatg ggatacagaa aactcattac taagtgattt
     9181 attagatgga gtattactca tccccctgct actagaactg aaaaaacaaa acttactgga
     9241 tgaatcaaaa aaaatattta acacattaac aaattccctt aaacaagaac tatcaacatt
     9301 attcatcaat ttaggatggg cagaagaaaa aacagaaggg ctatatttaa cagatatagg
     9361 tagatttatg cgtgacagat ccttaaactt aggaacaaca gcgtcttatg ctcctatgtt
     9421 gttacagatg aaagaattac tatttggaaa tcctcagaga gtatttcaaa gaaataagac
     9481 tgaaaaagaa agacacgtaa atagaacatt aaatgtagta gcaagtggct ttcaacacga
     9541 aaagtttttt gccgatacag ataaaatcat catatctata tttaaccaac agccaataga
     9601 agagcaacca agctatatag tagacatggg ttgtggggat ggaacgctac tgaaacgaat
     9661 atataaaatc atcaaacaat tctctgctag gggaaaagta ttaacagagt atcctatcat
     9721 catggtagga gtagactaca atcaagaagc attagatgtc acagataaaa atttagtaga
     9781 tattccccat ctagtcattc caggagatat aggagcacca gaaaaattat tagagcaatt
     9841 gaaagcacaa ggaatagaac cagaaaaagt attacatatt cgttcattcc tagatcatga
     9901 ccgaccattt atagctccaa aaaatacaga aatagctcaa gcacgttctc agttagatta
     9961 tcaagtagta gatgtagatc gagaaggaaa gctgatacca cctcacatag cagtacaaag
    10021 tttagtagaa cacttagaaa gatggtcatc aataataact agacatggat tattgctcct
    10081 agaagtacat agtttaacgc cagcagtagt caaaaaatat atagacgaaa gtgaatctct
    10141 gcattttgat gcctatcatg ccttctcaat gcaacattta gtagaagcag atgtgttctt
    10201 gatggcagca gcagaggtgg gtttattttc acggaaagaa gcttttcgta agtatccgaa
    10261 aacgttgcca ttgactcgaa tcacagttaa tcattttgaa aagcgtaaat atcagatacg
    10321 gtatgcaact gtaaacgata taccaaatct gttaaagtgt gcgacattta atcaacctgt
    10381 aaacgaaccc ttctttcaag ttttattgaa acaaactcca acagcacatt tattattaga
    10441 atatcaaggt gaattggtag ctgcaatctt cacagaaact aaaaattcta atgaggtgct
    10501 aggaattcgt gagtttttag taaggacttc tgtagaaaat tggcaagtat tagcaaaaga
    10561 tttactagaa tttgtggaac agtggggagt agtcaaacca ggaataaaag aaatagaagg
    10621 attgttaaaa taccatgaag ccatctcaaa ctttcaaaaa tcaaagtggt atcaatcttc
    10681 agttttaaac aaaaagctta tagaaaaaat aactctacac gaattagcta ctttagaact
    10741 atgtaattta atggctccag aatatgagct agaagccttt gccgcacgtt ggcttttgcg
    10801 tgtttttcaa gatatgggtg tatttctcag agagggtgaa tcttatcagg agtctgagtt
    10861 ggtttcccag ctaaacatct caccacgtta ccagagactt ttaggtgctt tgttacaaat
    10921 tttgcataag cgtggtattc taaaaattga gaaagataga gtgttcacat tagcaagatg
    10981 taagaccttt gccttagaaa atatttcgtc tgaagtttct gctttttatg attatttttc
    11041 tgaaaaatat cctgctcatt tatcctggtt aacagtagtc aaaaggtgtc tagagaaata
    11101 tcctttgatt ctacgcggtg aagttgatgt caacgaagtt gtttttacag atggggatat
    11161 ggagctattt gctggactat ttctaggaca tcgtgttgct gactacttta atgagttgct
    11221 agcagatggg gtttgctggg aagtagaaca gcggttgtta gaagaaaaga gggcacaacc
    11281 tattcggatc ttggagattg gagcaggaac aggaggtgtt acaggaatat tgctagaaaa
    11341 gctagcttct catgcagagc aaattgaatt ttggtttact gatatttcta gcgtttttac
    11401 acgttatggt gagagtaagt tcaagcagtt tccttgggtg aaatatcaaa cctttgacat
    11461 agaaaaatct cttgatgctc aggggataaa gtctgaaagt tttgatgtgg taattgctaa
    11521 taacgtactc cataacacaa aattaattca tcaaacctta aataacagta actcactatt
    11581 aaatactggg gggttattgg cattactaga gtttactcaa ccaattgata ttcttttata
    11641 ctttggaggg ttgcttcaag gattttggtt gtttgaagat ccagaatacc gactagaagt
    11701 tggttgttta ctgagtatac cactgtggca aaaagttctc agtgattgtg ggtttgatga
    11761 aataatacca ttgggattac cctgtgagat gcacgctctt tctaaggcaa gagaatctgt
    11821 tatatttgct cgaaagcatc aagtacagga gaaaacattt tctgaaaaaa ttaaacaaaa
    11881 tttgacagaa aatggtaagc atgggcaggc agaattcgat tttattagta ttaataattc
    11941 acaagaaagt tcatccaaat tagaaatttt tgaacaggaa tgtcgaaaat tattaaaatc
    12001 tctactgggt gttcaacgta tggagagatt gcctggtgac acaccactaa tggagtcagg
    12061 aatggattca ctggagttgt tagaatttcg tgctcttata gaaagaaagt ttgggattaa
    12121 gttaaagtct accttctttt ttagttacaa aactcttata gcggtagcag agtatctttc
    12181 agaacgggaa gatattaatt ttagttagta ggactatgac tgaaaaaaaa acaacgtttt
    12241 cacaggtcca cagggggaaa ttttgaatca gggggaaaat ttgaatgcat tctaaccaga
    12301 gcagttcact agcaagaata gccattgtag gtgtggcttg ccgttttcct ggagcagata
    12361 ctaaagaaga attttggcag ctacttaagg aaggtcggga ctcaatgcag aatcttcctt
    12421 cagagcgttg gggaaatcta tttaactcca tgagttcaga aatagattta tctattcaac
    12481 gcggtggttt tttgaaagat atagatttgt ttgactcatc cttttttagg attactccta
    12541 gggaagcgca gttaatggac ccccagcaaa ggctgttgtt agaattgtcc tgggaagcga
    12601 tggaagatgc aggatatgca agggatacat taaagggtaa atcagtaggg gtttatgtag
    12661 gagtttgtca ctatgactac agaagtttat tagaaaaagg tttggagaca gccgaaatag
    12721 ctcaaattgc tactggtaca gctccagcaa cttttgccaa tcgcctttcc tatttttata
    12781 attttcacgg ccctagctta actgttgata cggcttgttc cagctctttg gtagcaatgt
    12841 atgaagcagt aaatgcaata cgtcgtgggc agtgtcaaac agcattggta ggaggcgtta
    12901 atttaatgtg ttctcctgtg aataaccaag tttatagtgc tgcgggtatg ttatctcctg
    12961 atggagtctg ccgggtgttt gatgcgggtg ctaatgggtt tgtcagggga gaaggagggg
    13021 cagtagttgt acttaaagat tatcaaaaag cgttgacgga tggtgattct atttatgggg
    13081 ttgttcgcag tgtagcagtg aatcatggag ggcaagcaag ttcttttaca gcaccaaatc
    13141 cccaagctca ggcaaaattg ttggaacagg cttataggga agctaatatt gatatagagt
    13201 cggtaggtta tattgaagca catggtacgg gtacatctct aggagaccca attgaggtcg
    13261 aggctttaaa tgaagcgttt aaagggttga gttcaagtgg taagttacct gctaatagtt
    13321 gtggtttggg ctcagttaaa acaaacattg gtcatttgga aggggcagca ggtttggctg
    13381 gactaatcaa agttttgctg tgcatgaggt atgcaactct tccatgttca ttaaattatc
    13441 agcaacttaa tcctgatatt gaattagaag aaggtccgtt ttttgtggtg gacaagcttc
    13501 aatcttggga aataaaagtt gatagggtag gaaaacctta tccacttaga gcagggttga
    13561 gtagctttgg ttttggcggt acaaatgctc atgtagttct tgaggaagga gaaaataaga
    13621 aggaaggaag aagaggggat aaggaacctt cagttcatct attaaccctt tcagctaaaa
    13681 ctgaaacagc tctttcagag ttagtcagtc gttatcaaaa atatttaaac actaatgcag
    13741 aatcagagtt agccgatatt tgttataccg ctaatactgg gcgagtccat tttaaccatc
    13801 gactagcagc gatcgcctca aacaaacagg agttagtaga aaaacttaag gaataccaag
    13861 ctggggaggc aacagcggga gtattaatag gggaacttgc agaacgcata agaacaccga
    13921 aattaggttt cttattcaca ggtcaaggtt cccagtatgt caatatggga aaacaactgt
    13981 ataaaacaca gcctgtattc cgtgaagtat tggataagtg tgatataata ttggaaacgg
    14041 aaatagaatg ttctctatta gatgttctat ataacaaaac tacagattct caagattcat
    14101 ctttaataaa ccaaacagct tacactcaac cagttctgtt tgcaatagag tatgcgctat
    14161 ttaagttatg ggaatcttgg ggaattaaac ccagcatagt aatgggtcac agtgtaggag
    14221 aatatgtggc tgcttgtgta gcaggagtct tcaatcttga agatggtttg agattaatag
    14281 ctgctagggg caggctgatg caacagttac cttcaggtgg agaaatggtt tctgtgatgg
    14341 cttcagaatc tacagttagc agactcctag aacctcacaa aaaagaaata gcgttggcga
    14401 agcccgccgt aggcatcgca gcaataaatg gaccagaaag cacagttatt tctggagact
    14461 ctgtagcagt aacaggtgta gtaaatgacc tggaagcaaa gggaataaaa actaaaaaac
    14521 tagaggtatc tcatgctttc cattcaccat taatggaacc aatgttagga gagtttgaag
    14581 ctatagctaa tcaactaacc tacaatcaac ctaaaatacc tattatatct aacgttacag
    14641 gtacaaaagc agataatact attgcttccc ctcaatactg ggttaatcat gtcggtaaac
    14701 ctgtaagatt tgcccaagga atggaaacgc tacatcaaca agggtatgaa acctttatag
    14761 aagttggacc gaaaccagta ttgttaggaa tgggcaggca atgtctacca ggaaatgtag
    14821 gtgtctggtt gccatcatta cgtccgggag tggatgagtg gcaacaaatg ctttatagct
    14881 tgggaaaatt gtatgtaaca ggagtaaaaa tagattggtc aggatttgag tctgactcta
    14941 gtcgccagaa agtagcattg ccaacttatc cattccagcg agaaagatat tggatagaaa
    15001 taacagaaaa caaacataag gaacatcaaa agtcagaaaa tataagtgac acttcaattg
    15061 ttaaactact cactcaagga aaaacagaag ctctcactca acaactagaa acagaagcca
    15121 aattttcacc agaagagctt aaacttttac cagaaatatt agagacatta gccaaacaac
    15181 atcaagaaca attaacagca gtaaccatca aaaactggtt ctacgaaatc cagtggaaac
    15241 ccttagctca aaacaacccc aatgcaaaca ttgaacctag tcattggtta attttagccg
    15301 ataccacagg agtagcagaa aaattagctc aaaaattaca acaacagggt cataaataca
    15361 gcttagttta tcgaggagag agctatcaaa gacaagcaac aggtacttat caacttaatc
    15421 ctcagattcc cgaagcattt gaaaagctgt atcaagaaat tcaacaaagt agtgaaactg
    15481 ccattacgaa gttaattcac ttgtggagtt tagatgctcc ccaatcaaaa gacttaaccc
    15541 tggaaaccct agaagaagct caattatggg gatgtggcag cgtagtacac ctgttacaga
    15601 ccttagtcaa aaactctagc attcctgaac tatggttagt aacccgtggg tctcaatcag
    15661 tattatccca aacagaaaaa aatctaacag gactagcagc gtcacccttg tggggattag
    15721 gtagagtagt gtctaatgaa catccccaat tatggggagg attagtagat ttagacccac
    15781 aagctgcagc aggagacgaa gtagaaatgc tgtggcaatt attagttaat gaacaagaag
    15841 aagataatct agctgtacgg ggagaaaata cctatgtagc tcgtctggcc aggcaagaac
    15901 ctcaagaatt tcctgaatcc ctatccttat catcagatgg tagttaccta ataacaggag
    15961 ggttaggagc tttagggtta catactgccc aatggttagt atccaaggga gcgaaaaata
    16021 ttgtcttaac tgggcgtcgc cctccctcag aaaaagtaag tgaatctata aaaaaattag
    16081 aagaaacagg atgtcaagtg aaggtgatgt tgggggatgt ttctgttgaa gaagacatag
    16141 gcaaaattct caaacaaatt cagatatcaa tgccaacact caaaggcata attcatacag
    16201 caggagtgtt agatgatgga accatacaac aaatgaattg ggagcgtttt gccaaagtca
    16261 tgtcgcccaa ggtaaaagga agttggcatt tacataaatt aactgaaaat cagccattag
    16321 atttctttgt gtgtttctcc tcaatagctt cgatgttggg gactcttggc caaggaaact
    16381 atgctgcagc caatgccttt atggatgctt tagctagtta tcgttgcagc agaggattat
    16441 caggattggc gattaattgg ggagcatggg catcaggggg aatggctgct cgtttagcag
    16501 tggagcatca aaataggatg cacagcagtg gcataactga gatggcgacc aaagaaggaa
    16561 tgtatgcctt agatttacta ttaacaaatg aatctgctac agctcaggta ggtgtagcaa
    16621 gtatagagtg gcaggtactc tcagaaagtt ggagtggtat caaaaaaaat tcattgctac
    16681 gagaattatt agagaaggag gaatgggcag caaaagatac acgacaccaa aaagttaaag
    16741 ccgaattttt agcaaaatta gaggaggcat cactagagaa acgtcaggaa attttaactg
    16801 aacacattcg agtgcaagta tctcaggtac taggtttaag ttcatctaaa ttaccagaag
    16861 taaatgtagg ttttgcctct atgggaatgg actctttgat gacaatagaa ttaaaaaatc
    16921 gactgcaaaa tcaactagga accaagttgc ctgagacaat agctatcgaa tatccaacta
    16981 ttgcaaaatt gtccttaggt atcaaaaaaa attcattgct acgagaatta ttagagaagg
    17041 aggaatgggc agcaaaagat acacgacacc aaaaagttaa agccgaattt ttagcaaaat
    17101 tagaggaggc atcactagag aaacgtcagg aaattttaac tgaacacatt cgagtgcaag
    17161 tatctcaggt actaggttta agttcatcta aattaccaga agtaaatgta ggttttgcct
    17221 ctatgggaat ggactctttg atgacaatag aattaaaaaa tcgactgcaa aatcaactag
    17281 gaaccaagtt gcctgagaca atagctatcg aatatccaac tattgcaaaa ttgtccttat
    17341 gtatagagga attaatggga tggaagacaa cagaaattga cccattatct gaagaaacaa
    17401 gattagagat gatggagcgc tcaagaagtg aagcaatagc catcatcggc ataggctgta
    17461 gatttcccgg aaatgccaac acaccagaaa gcttctggca attgttatcc aatggcaaag
    17521 actccattac agagattccc ctagaacgtt gggatctaga ttcctactac gaccccaacc
    17581 ctgatactcc agggaaaatg tatatccgtc acgcagcatt agtagaaaaa gtagatcagt
    17641 tcgacccacg attttttgga atctctaacc gagaagctta tagtcttgat ccacagcaac
    17701 gcttcatttt ggaagtaact tgggaagctt tagaaagagc tggtattaac cctcaacaat
    17761 tagaaaacac tcagacaggg gtgttcctgg gtatcggtca aaatgattac gcgaatttag
    17821 gttttcacca agcagccgaa gatataagcc cttacgatgc tacaggaaat ttgttttgtt
    17881 ttgtagcagg taggttatct tactttttag gaacgcaagg tccatcaatg gcaatagata
    17941 cagcttgttc atcatctcta gtagctatcc atgaagcttg tgagagtctg cgtcagggtg
    18001 agtccaactt ggctttggct ggaggagttc aactaattct ctctcccgaa gtaacaaccg
    18061 cactatcaag attaaaggct ctagcacctg atggtaagtg taaaactttt gatgctgctg
    18121 ctgatggttt tggtagggga gagggatgtg gcattgtggt actgaagcgt ttgtcggatg
    18181 cgctcaagga tggggacagg atatcagcag taattcctgg ttcggctgtt aaccatgatg
    18241 gaccaagtag cggaatgaca gtaccgaata aactggctca ggaaaaactg attcagaaag
    18301 ctctcaaagc agccaaggta aaaccgttac aagtgagtta tgtggaagct catggtacag
    18361 gaacttctct aggagatcct atggaagtga gagctttagc tagggtgttt gaggagggac
    18421 gtgatcagga aaatccattg aacatcggtt cagttaaaac taatatcggt catctggaag
    18481 cagcagctgg aatagcaggt atgattaagg tgattttgca attgcaacat caggaaattg
    18541 tgccccatct gcattttgct aatcctaacc cctatgttga ttgggagaat atgcctctac
    18601 aagtaccgac tcaactgact ccttggttgt cgaaagggga gaaaagggtg gcaggagtta
    18661 gttcttttgg tatgagtggt acgaatgctc atatagtttt agaagaggct cctattgaag
    18721 tcagaaggca gaagtcagaa gtcagaagtg aagaatatct agaacgtccg gttcatatac
    18781 taactctgtc ggccaagact gaaaaagcac tagaagattt agttaatagt tatgaaagtt
    18841 atttagaagc cgaaaataat gataattatt taggggatat ttgctacaca gccaacatcg
    18901 ggagagcaaa atttgaccac aaattagcag tggttacttc tgataaacaa gagttattag
    18961 agaaactcaa acaatataaa caaggtgaga atgttgctgg aatcttttca ggaaaacaaa
    19021 taagtgaaac tagaacaaaa atagccttta tatttactgg tcaaggttct caatatctgc
    19081 aaatgggaag gcagttatac gaaactcaac ccacttttca taaaattatt gaccagtgta
    19141 gtgaaatgct ggtaaaatat ttagatgttt ctttattaga tatactttat ccagttgagg
    19201 ttaaagatga aagttcgact ttgatagacc aaacagctta tactcaaccc gctatatttg
    19261 cccttgaata tgccctagct aaattatggg aatcatgggg tataaagcca gatgtagtca
    19321 tgggtcacag tgtaggagaa tatgtggcag caacagtagc aggggtattt agtttagaag
    19381 atggtttaaa attaatagcc atgcggggac agttgatgca aaagttaccc tccggaggtc
    19441 agatggcatc tataatggca tcagaatctc aggtaataga ggcgataaaa gaatatagtt
    19501 cccaagtaac aatagcagca gttaatggac cagaaattat agtaatttca ggtgagagtc
    19561 cagccatttc aaaaatttgt agtaaatttg aatcagaagg agtcaagacc aaggcgctac
    19621 aagtatctca tgctttccat tccccattga tggaaccaat gttaacagaa tttgaagcag
    19681 tagccaaaga aatatcctat aatcatcccc aaataccact aatatcaaat gttactggtc
    19741 aagaagtaaa tggagaaata accactgctg aatattgggt gcgtcatgtg cgtcaaccag
    19801 taagatttgc ggaagggatg gaaactttac acaaacaagg tgctgaaatt ttcctagaaa
    19861 taggctcaaa accgatactt ttaggtatgg gtcgtgagtg tctcatggga gaaaaaaaac
    19921 tatggttgcc cagtttacgt tcaggaaaac cagactggtt acaaatgcta caaagtctgg
    19981 ggcaattgta tgtacgagca ataaaaattg attggttagg atttgatcgg gattatttcc
    20041 gtaataaggt agagttacca acatatcctt ggcaacgaaa aaggtattgg ataacagata
    20101 ttagacaacg gaaaagtcaa gacaaaaaaa gcataacatc tgaaaaaaaa gtacaacttg
    20161 atggagtaaa tattcaacta aaggaaatac aaatgaacga caaaatctta cagcaaccaa
    20221 aactaaaatt atcagatcca gaatcactat atttatcgaa tgctgaatca actatagagg
    20281 ttccaacaaa agcagttcaa gtaaaacctg ctgctgatat tgaatctgaa aatataactc
    20341 aattgaatag ccttgataga gatgtgactc aaatcataga aaccctcaaa gaaagtttgg
    20401 cagatgcttt atatgcagat ataagtgaaa ttgaagaaga caaaaagttt gttgatttag
    20461 gtttagattc tattgtggga gtagaatgga taactaacat caataaaatc tacaatttaa
    20521 atataaaagc tactaaacta tacgattacc ctactttgcc agatttggct aaatatgtcg
    20581 ctcacaccct atcagctcag ggtagaaata ttgatgtaga gcgatcgcca tctgactcaa
    20641 gtcaagcaag cattagcaag caatctcaac taactgatac ccagagcaat ttctcacaag
    20701 tcaaggaaat tttgaaacaa caattagcag atgctctgta tgcggatatt agtgaaattg
    20761 aagtaaacaa gaagtttgtt gatttaggtt tagattctat tgttggagta gaatggataa
    20821 ctaatatcaa taaaacctac aatttgaata tcaaagccac taaaatatac gactacccta
    20881 ccttattaga tttcgcaaaa tatattaacc aggaaattta ttctacagga gtaagtagat
    20941 tttcaacgga gcataaagaa tttaatcaaa aagactattc atctggaggt tcgcaagagg
    21001 aaatgacaca aaaattacga tcaatattga agaaagtggc caataaagaa ttaacagttc
    21061 aggaaggaaa taaaatgatt caacaaataa aaaatcaatt aaagtaaaaa tatagtataa
    21121 tttttaagga aataaaattt tatgaacaaa gagcaaatat ttcaaataat aaaaaaatat
    21181 acctacgaaa tagcaccaga attagaagaa gtacctatat cacctactga tagtctcaaa
    21241 aacttgggga ttgattcagt aaatagggca gaaattataa tgatggtaat ggaagagtta
    21301 tcattaaata tcccgcgtat tgaattagct ggatccaaaa atataggaga actggctgat
    21361 atatttgcat tcaaattaga agcaataaat tcacaaagct agaaggccta tcaatgagta
    21421 acatagaaat aacaggtatg ggcattgtta cttccattgg tcaaggagtt gctactttta
    21481 aagaagctct gttatcaggg aaaactcaat ttgcttatct aaaacagcca ggacgtgaaa
    21541 gcatcaaacc atttattggt gccgaaattc ccgatattga cgccaaaacc ctatttcctg
    21601 agtacagtgg actgttacgt actgctacta agagcgccca agttgcaata gtagctgtcg
    21661 ctgaagcctg gcaagatgct caactcacct ccagccaagt taacccagaa cgagtaggat
    21721 tagttgtagg tggttcaaat ttacaacaac gttatcagca gcaaacctgg caacgttatc
    21781 actcacgtca ggagtttata cgaccaactt atggtctgac cttttgggat acagatatat
    21841 taggtctgat ttcccagtgt tttcagattc aaggtgaggg ctatagtgta ggtggagctt
    21901 cggccagcgg agcagttgct ataattcatg ctgctcgtca aattttaatg gggaacagtg
    21961 atgtttgcat tgctctggga gctttatccg atctatcagg gtatgaattc caagcactaa
    22021 tgaatttagg tgcaatgggg agcgaacgtt ttgccgatcg cccaaacctt gcttgtaggc
    22081 catttgacca agaccatgat ggctttattt atggagaggg ttgtggagca gtgattttag
    22141 agagaactga ccgcgctcaa caacggggcg ctcaatccca tggccaactt aagggttggg
    22201 gattaacttt agatgggaac cgtagtcccg aaccttccca aaaaggggaa gaacgggcta
    22261 taaatactgc tttagccatg gcagaccttc agccagagag tattgattat gtgaataccc
    22321 acggtactgg ttcccccctt ggcgacaaaa cagaagtggc agctttcaaa tcagtaggac
    22381 ttcagcattg cctatttaat tcaacaaaat ctttaatagg ccactgctta actgctgctg
    22441 gtgtagtgga agcgatcgcc accatattac aaatgaagtt tggtttttgt catccaacta
    22501 aaaatttagt taatcctatt gataccagtc tcaattgggt gaaagaaact tctgttcaag
    22561 ctgagattaa atatgctatc agcaacagtt ttggttttgg gggtatcaat acagctttat
    22621 taattggaca ggagtaaact catgcaacaa gttggaattg aagcactaaa tgtatatggg
    22681 ggttcagcta aactagatgt gcgaatgcta ggcgaagcac gtcacttaga catgactcgc
    22741 ttcgataatc ttctgatgaa agagaagaca gttgctatgc cctatgaaga tccagtttct
    22801 tatgctatta atgcagcaaa acctattatt gatagcctca gcgttctgga aaagcaacaa
    22861 atcaaaatgg tgatagcttg tagcgaatct ggcattgatt ttggcaagtc tatgagcact
    22921 tatatccagg attatttggg actaaatcgt aactgtcgaa tgtttgaaat aaagcaagct
    22981 tgctactcag gtacagcagg tttacaaatg gcattcaatt taattttgtc ccaaacctgt
    23041 ccaggggcta aagctttggt tataggaact gatatatttc ggcctgttgt tgtagaggga
    23101 ggagaagctc tcagcgaaga ttggtctttt gtggaaccaa gcagtggtgc tggagcagta
    23161 gctattttag tcagtgatgt tcctaaaatt ttccaagctg atgtaggatg taatggttac
    23221 tatggctatg aagtcatgga tacttgcaga cctaacccag actcagaagc aggagatgca
    23281 gatttatcat tgctatctta cctagattgt tgtgaaaatg cttaccggga atatcaagat
    23341 cgagtagaag gagtagatta ccaaaaaact tttgattact tgagctttca tactcctttt
    23401 gggggtatgg tgaaaggggc tcacagaagt atgatgcgta agtttaaaag ggcaaaacct
    23461 gtggagattg aagaggactt tcagaaacgg gtgatgccgg gattagtcta ttgtcaacag
    23521 gtgggtaata ttatgggagc tacagtattt ttatctttag ctagcatgat tgataatgca
    23581 gattttagca aagcccgacg aattggtgta ttctcttatg gctctggttg ttgttcggaa
    23641 ttttatagtg gagtcgtcac cccgcaagga aaggaaattc aagctcaaca aaaaatttca
    23701 tcacagttag caatgcgcta ttccttaagt atggaagaat atgagcagtt actaagtcat
    23761 agttcggcag ttgcctttgg cactagaaat gttaccctag attacaaact atttcctggt
    23821 gtgtgggaac aaattgaagg taaaggtcgc ttagtgctga aaagaatcaa ggaatttcac
    23881 cgagaatatg aatgggtata gccatgagtt atcaaaccct gaaaatcagt tatcaagatg
    23941 ttgtacaaag gattcagata tatcgacctg aatctaacaa tagcatcaat agtcaattaa
    24001 cgatggaatt gttgtcagct ttgcaagctg ctgaagcaga ggaagttgtt aaagtagtga
    24061 tattagaagg actacctgat gtattttgta cagggatgga ttttgaagaa gtggcaacag
    24121 caaaacaatt tgatccaaaa gctagtgcta atggttacta caatattttg aaacaaatgt
    24181 ctcaaagtag caaagtaatt ttgtcacttg tgcgtggtaa agtacaggca gggggagttg
    24241 gtttagtagc agcaagcgat ctagttattg ctgatgaaac ggcaactttt gttttatcag
    24301 aattattatt tggattatta ccagcttgtg tattgccttt tttgattcgt cgagtgggat
    24361 ttcaaaaagc ctaccgttta gcactaacga ctcaagctat ttcagtatca gaggctgata
    24421 agtggggatt aatagatgaa tatggcagta atattaatca gttaataagt aaatatattc
    24481 gacgtttaaa gtatttaccc tcatcagggg tgaaagagtt aaaaaattat attaatcagt
    24541 tatggattat tcaggcagaa actcaaggtt tagccgtcaa cgagatttct agcttaatag
    24601 cagaacctac tgttcaagaa aaaattaaac gttttcaaaa agaaggatta tttccatggc
    24661 aaacctaaat cttaatttgg acttagtaga gggcaactct gatgtagtac aactggtgga
    24721 gttgggtaat ggtgtcgtgc aaatcacgat gaaagatgaa gaaagctgca atggcttttc
    24781 tcctggaata attgaaggat tatacaaatg ttttggtgca gttgctcaaa accaaagtta
    24841 taaagtagta attttgacag gctatggaaa ttatttctgt tcgggaggga caaaagaacg
    24901 gttaatcagt atttggaaag gagacagcaa atgtaatgat ttagattttt ttagaatagc
    24961 attagattgt gaaataccag taattgcagc tatgcaaggt catagtattg gcggtggttt
    25021 ggttttggga ttgtatgcag atttagtagt gttaagtcaa gaaagtattt acactactaa
    25081 ttttatgaag tatggtttta ctccaggtgt cggatgcacg ttaattctcc ctgagaaatt
    25141 cggtgcttta gggtttgaaa tgatgtatac tgcccaaaat tatcgaggga aagaattagc
    25201 tgaacggggt gtttcttttc cagttgtacc gagaaaagat gtgctagaag tggctaaaaa
    25261 tatagcctat gaaatgtcgg aaaaacccag actatcttta ataactttaa aggaacactt
    25321 aacttcaaaa atccgcaaaa cgctaccagg atttatagat aaagaagtag ctatgcacga
    25381 aataaccttt caccaaccag aggtagcaag tagaatagag gaaaattttg acaaaaggac
    25441 aacggcaagt aataaccctc aaaattttcc tcaagaggct gtaagaaaag aaataagaac
    25501 agattcattg aattgtcaac catttcagtt gaagacattt agttatggtt cgttaaacaa
    25561 tttaactttg gtacctctag aacgtagagt tccaagccca agtgaagttg aggttcaaat
    25621 caaaactgta ccagttaatt ttcgggatat actcaatgca cttggtatgc tccaagagta
    25681 ttacgaaaaa acatttggca ttgctaatgc tgaagatctc acttttggtt ttgaaggtgc
    25741 aggtactatc gtagctgttg gggcagaagt atcgcagtgg caagtcggcg atgaagtaat
    25801 ggtaatgaga attcacgatg catttagtag ctttattatc tgctcgccgg acaaactggt
    25861 gcgtaaaaat tttaatctga atatggaaga tggagctagt atttgggggc cgttttcgac
    25921 tgcatatcac gggttgatta acttagccaa aattcagcca ggagatagag tattaattca
    25981 cgctgcttca ggtgggattg gacaagcagc aattcagttg gctcaacttt ttggggcgga
    26041 agtatttgct actactagtc caggtaagat gaattatctc cgggaacagg gaattaagta
    26101 tgtgatgaat tctcgaacga tggagtttgt aaatgatgtg atggaattca ctcagggccg
    26161 tggggtagat gttattctca atagcctgac tcatggagaa tacatccaga aaaatctaga
    26221 gatccttgcc gatagagggc gatatgttga acttggtaag ttgggcattt ggagtcacga
    26281 gcaagtctat cagaaacgcc cagatatcaa atattttact tttgatttgt tagaagaatt
    26341 tgccaaagat aatcaattgt tttctcagat atgggataat ttggcacttg aatttgaccg
    26401 cgatcgcttg aagccactac cttacaaaac atttccaata gaagatgttc ttaaagcctt
    26461 tgattatatg cgacgcggga agcattttgg cagggtagtg gtagttatgc ctgactccta
    26521 ttctagacag gaacaagagt tggatgctcg gttatccatt gaaaacaaaa tgactaaaga
    26581 ggaacagata ttatttcaat tacaatctgg tgaagtttcc ttagaaaatg cggaacaact
    26641 attgttagga aatacggaaa cagaaacaca agataaagct atagcagaaa atcaaataga
    26701 taatattcaa aacaagttaa ttaacatgga tagctcagag aaaatcttat ctttgattag
    26761 ttcagtagaa atatctttag aaacagcaga aaaattatta ttagaagtag tagaaccaga
    26821 agttaaaaca gaggttaatg atgaggttaa tcctagtcaa aatcatatac caactacaga
    26881 tatagcgatt attggtattt catgtagata tccaggagcg aataactgga aagaattttg
    26941 ggaaaattta aagaatggaa ttgacagtgt aacggaagct cctcctggaa gatgggaaga
    27001 aaaaaattgg tatcatccag atccagataa tccaggtact tcctattcaa aatgtgccgg
    27061 ttttttagat gaaattgata aatttgaccc tttatttttt catatttctc cggaagaagc
    27121 ttggtttatg gagcctgagc aaagaatatt tttagaagaa gcttaccacg ctatagaaga
    27181 tgctggatat gctacagact ctcttagagg taaacaatat ggagtatttg tgggagttac
    27241 ggtaaatggt ggttatctta agttgttgtc aatttcagga ttagatgttc ataggatggc
    27301 ggctacagga aatggtccgt caatgatacc agcaagaatt gcctatatgc ttgaccttca
    27361 agggccagta gtagctattg atactgcctg ctcgtcgtca ttggtagctg ttcatcaagc
    27421 ttgccaaagc atacaacgag gagagagcga aatagcgatc gctggaggta ttactctaat
    27481 gccaacatca gacttccaaa taatgtcaag tcagtttcaa gttgtatctc ctgatggacg
    27541 ttgtaagact tttgatgctt cagcatcggg tacagcctgg agcgaaggtt gtggtgttct
    27601 cttattaaaa agctacagtc aagcaattca agacaacgac catatttatg gagtaatcaa
    27661 aggaacagga gttaattatg atggtaatac taacgggatt agtgccccta gtagtcaatc
    27721 tcaagccagt ttagaagaag cagtttatca gaaatttgga attaacccag aaactattag
    27781 ttatgtagaa gctcatggta cagcaacacc tctgggagac ccgatagaag tagaagcttt
    27841 aacagaagcc ttttctaaat ggacgaacaa aaaacagttt tgtgcgattg gctcggtaaa
    27901 aactaatatt ggtcattcag cagcggctgc cggagtttct ggtttgatca agacaatttt
    27961 gtgcctcaaa aatcaaaaat tagttccatc cttacatttt aatcaaccaa acccacatat
    28021 tgactttgaa aatagccctt tttatgtcaa tacaaaatta aaagattggg aagtgcttga
    28081 aggccaacca aggcaagcta cagttagttc ttttggtttt agtggcacta atgctcatat
    28141 agttatagaa gaggctcctt ctcaagttaa aagtcagaat attgttgaac gtccgatcca
    28201 tctgttaact ctatctgcga aaacagaaaa ggctctagaa gatttagtca gtaattatca
    28261 aaattattta gaaactaatc ccgagttacc actagcagat gtatgttata cagcctctac
    28321 aggtagagca cattttaatt atcgattagg agttattgct tctgaaccaa aagcattaat
    28381 agagaaacta cttgggtgga aagctcagga agaattagta ggactatttt caggaaaacg
    28441 aaatagcgaa ggtcagaaaa tagcattcct gttcacaggt caaggttccc agtatgcgaa
    28501 tatgggaagg caactttatg aaaaagcacc aactttccgt caagctttag aggaatgtga
    28561 ccaaatttta caaccctatc tagaagtacc tctattagag gtcatatact ctgaggatgc
    28621 acaaaagtca agtgataatc tattagacca aacagcttac acccaaccag ctgtgtttgc
    28681 tgttgaatat gctttggcta aattatggtc ttcatgggga atcaaaccat gtgtagtcat
    28741 gggtcacagc gtaggagaat atgtagcagc aacagtagcc ggagtattca gtttagaaga
    28801 tggtctgaaa ctaatagcca tgcgaggaaa gttgatgcaa aagttaccct ccggtggtga
    28861 gatggtatcc gtaatggcat cagagtctca ggtaacagag gctataaaag aatatagttc
    28921 ccaagtaaca atagcagcga taaatggacc agaaagtata gtaatttctg gtgagagtgt
    28981 agccataaaa aatatttgta gtttatttga atcagaggga ataaagacca agcagctaca
    29041 agtatcccac gctttccatt ctccaatgat ggaaccgatg ttagcagagt ttgaatcagt
    29101 agctaaacaa gtcacctata atcaacccca aataccacta atatcaaacg tcacaggtac
    29161 tgaagtagat ggagaaataa caaatgctga atattgggta gatcatgtgc gtcaaccagt
    29221 aagatttgcc cagagtatga aaactctaga gtcggaagga tatgaaacct tcctagaaat
    29281 aggaccgaga ccaatattgc taggaatggg aagacaatgt gtaacagaag atgtaggaga
    29341 atggctgcca tcattacgtc caggggtgga tgaatgggaa caaatgctat caagcttagg
    29401 aaaattgtat gtaaaaggag ccaaaataga ctggtcaggg tttgactctg attatactcg
    29461 ccagaaagta gtattaccca catatccatt ccagggagaa cgttattggg tagaaaccaa
    29521 caacaacttc tggcctcaac ggcaattttc ccaaggggaa aacctccatc ccctattagg
    29581 tcaaaagcta aattgtgcag gggaacaaca aatatttgca tcacaaatag gagaaaactc
    29641 acccaactat ctgagggacc accgagtatt taatcaagca ctatttccca taacaggcta
    29701 cctagaaata gcaatagcag caggaaatca ccaattaaaa acatcccaga tagtaataga
    29761 agacctaacc ataactagag gatggatact accaacagga gaattaacca atgcccaaac
    29821 catactcacc ccaatagata accaaagcta taagtttcaa atattttctc aaccagaaca
    29881 acaggagtgg agactccaca cgacaggaaa aatcagaaaa gagtcaaccc cccctactca
    29941 gacaaaagtt gacctagaaa aatacaagag tgaatgtaat caaacaatag aagtcaaaca
    30001 acattatcaa aaatgtcaac aagtagggat agactacggg aataccttcc aaggcatcca
    30061 agaattgtgg tcaggttcaa accaagcatt aggttatatc aaactgcccg aagaattgat
    30121 aacacaaaca agcgactatc atttccatcc agcactatta gatgcagcct tgcaagtaat
    30181 gttttatgca ctgccagcaa cggataatga caaaacttat ctgtcagcag gaatagaaga
    30241 attcagacta tataagactc ccgggctgag tatatgggca tatgtatcag taaccagtca
    30301 agaagtggaa actccagaaa gtttgacggc tattgtcacc atagtaactc cagaaggaga
    30361 aataattgcc aacatcaaag gtttacaagt caaactagca acaaaacaga ccctactggg
    30421 aacagaaacc gaatcaatag aaaattggtt atatgaagta gagtggagaa acaaaggtat
    30481 tttaggtaaa ctactcccac cagatttcct catacctcct atacaaatca accaaaaatt
    30541 aactccaact ctgacagaat tagtaactca agtagataat gaaacaacag cgtcttttga
    30601 aacaagctta gaagaattaa gcagagatta tatagtacaa gcattacagt caatgagttg
    30661 gtcatacaaa ccaacagaaa gctttgcatt tgatgtagca gcccaaaaat taggtatagt
    30721 tcctacccat cgaccactgt ttaagcgttt gctgcaaata ttaacagagt caggaatact
    30781 caactcaaag aatcagcagt gggaagtagc acaaacctta cctgaagtca agcctacgga
    30841 aaaaatcagc agtttacaga agaaatatcc agaagaaaca gcagcattga cactactctc
    30901 tcgttgtggg tctaaactaa gtggggtatt acgaggagca atagacccag gagagttagt
    30961 gttcccccaa ggagatttga cagcagcgac tcaactttat gaagactcaa cagtagcgaa
    31021 agtgatgaac acaatagtag aaaaatccat caccaaagct atagaaaaat ccccgaaaag
    31081 ccgggggctc aggttgttgg aaataggagg gggaacagga gggactacaa gctatatcct
    31141 acctcatcta actcctcagc aaaccgaata tacattcacg gatatagggg cattatttac
    31201 agccaaagct caagagaaat tccgggatta taagttcata aagtatcaaa ctttagacat
    31261 agaagtagac ccgacaactc aaggatttga ggctcatcaa tatgatgtaa ttattgcagc
    31321 taatgtactt catgcaacga cagatatgaa gcagacatta tctcatgtgc gagaactgtt
    31381 agcagatggg ggaatgttgg tgttatctga agcaacagct aaaacactat gggtagattt
    31441 agtatttggg ttgttagaag gatggtggaa attcagggat tatgaattac gaccagatta
    31501 tcctttgttg agtcgtgaaa aatggcatca tgtcttgaga gaaacgggtt ttactgaagt
    31561 agttactatg ccagaagtgg agggaatggc agaaacattg tcagcacaaa cggtaattgt
    31621 agctaaaagc tctcaaacga agttagaaca aaggaatgat gattctaaga gttggttgat
    31681 actggcagac tctgagggag tagggcaaca gttagcgacc ttactccgct cagtaggaga
    31741 ggtttgtact ttagtatttg ccggagaaag gtatcaacag atagctccgg gagaatttag
    31801 tattaatcct aatcaagcta aagattttga ggaggtaata gagacagtgg cagggaagtc
    31861 accatcattg tatggagtgg tacaatgttg gacgactgaa gccggagtgg ggaatgggat
    31921 taattctgag gagttaggaa gtttatcgaa gttagggtgt ggcacaactc tatctttagt
    31981 acaagcattg gtgaaaggcg ggttatcaac tgtccctcga ttatggttgg tgacaaatgg
    32041 tgctcaggcg gtgccgaata atcatccggt gataccagga gtagctcaat cttcggtatg
    32101 gggaatgggg aaagtgatta gctgggaaca tccagagttg aactgtactc gtatagattt
    32161 ggacccagag gagactttag agggtaaagt tgatgcccta tttaaagaaa tttggtcgga
    32221 ggatagggaa gaccaggtag catggcgtgg ggatagtcgt tatgtagctc ggttggtggg
    32281 tagtcatcat cggcaattag tggcacaaca agctgatggt aaaactcaaa agcccttaag
    32341 tttccgttct gaagcaagct atttgattac aggaggtatg ggaggtttgg gtttgctggt
    32401 agctagttgg atggtgtcaa agggagctaa acatttgata ttgttaggac gccgttcacc
    32461 ggatgatgct acgaggaaaa aaataaccga gttagaaatg gcaggagcgt ccgtggtagt
    32521 ggaaaaagcc gatgtgactg atttggagtc gatgaaaggg gtgttgcaga ggattgagga
    32581 gtcaaagcga ccgttagtag gagtgattca ttctgtgatg gtgctatcaa atggagtgct
    32641 acgaaatcag acttggtcta gttttgaaca ggtgatggaa ccgaaagttc aaggtgcttg
    32701 gcacttgcat caattgactc aaagtcaacc attagacttc tttgtgctgt tttcttcagc
    32761 aacatctctg ttgggttcac tgggtcaggg catggcaaat tattctgctg ctaatgggtt
    32821 tcttgatggt ttagctcatt atcgtcgaac tatgggatta ccgggattga gtatccattg
    32881 gggagcagtt tctcaagtgg gacgagcgct cgggcgagat acagagacag ccgctatgct
    32941 cagtaagaat gggatgggtt taatatctcc ggctcaggta ttggagtctt tggaactatt
    33001 gatgagtagt tcggatgtgg aagtaggggt gatgcctatt gagtggtcag ggtggcagga
    33061 gagagtggca cagtggccgt ttttagtgga ttggcaggaa actatattgg aggtagccca
    33121 accatcgaag tcagattttc tgttaaagtt ggaggctaca ccacctaatg agcttcgctt
    33181 gttgttggtg gctcatgtgc gtcgtcaggt ggctcaagtg ttgagaatta gtcatcctga
    33241 atcaattgaa atggatacag ggttttttga tttgggtata gactctttga cttctgtgga
    33301 gttgaggaat aagttgcaag gtagtttaaa gtgttcagta ccttctactg taactttgga
    33361 ctaccctacc attaaggcat tggtagaata tttatatcaa cagctattgt tagaacaagt
    33421 tagttactca aatactgtac caactgaaga aatcaatgaa gatagggagg agattactct
    33481 atgaaactga ccgaaattct atctcaaatc tctagccaaa acattaaatt atggacggaa
    33541 ggtgatgagt taaaaattag tgctcccaag ggaacgttaa ccaaagaaat tcgcgattta
    33601 ttatcccaaa ataaacttga attagtcagt ttacttcggc aaaagagtag taatatcact
    33661 gccacatcta gttggccgac cctgattccg gctccagagg aaaggtatca accatttcca
    33721 ttgaatgcaa tccaacaagc ttattggata ggtcgcaatg gattctttaa tttaggcaat
    33781 attgcgaccc atgtatacat agaattagat tgtgaaaact taaatttgga acgcgtcaac
    33841 caagcctgga ggcaattaat tgagcacaat gaaatgatgc ggatggtagt tttagcggac
    33901 ggcaaccagc aaatactcga gcaagtgcct ccctatgaaa ttgaagtttt ggatttgtcc
    33961 ggagagtctc ctcaaacaat tgcttcagag ctagagaata ttcgcaatca gatgtcccat
    34021 caggtgttac caacaaacca gtggcctttg tttgatttac gggctgcccg tttgaatgaa
    34081 caatggtgcc gtttgtatat cgacatcgat atgttgatct tggatggctt gagtttctat
    34141 atgttatttg agcagtgggc gcaactgtac aaggagccag agagtgaact accagcaacg
    34201 gaaatctcgt tccgagacta tgtgctagca gaattggcac tcaaagatag tcctcagtat
    34261 ctccgttctc agcaatattg gttcaaccgc ctcgatgagc tacctccggc accagaaatg
    34321 ccccaagcga aaataacatc tgcaatcacc aaccctcgct tcaagactca cacagctgga
    34381 ctatctacga cgaattggca acagttaaaa cacaaggccc ggaaagcaga tttaagccca
    34441 tcaggggtat tgttaagtgc ttttgcctat atattaaatt actggagtaa aagtccaaag
    34501 tttactatca acctgactat atttaaccgt ctgcccttac accctcaggt taatgagctt
    34561 ttgggtgatt tcacctcgaa tattttgctg gcggtggatc actcacaagc agttccattt
    34621 attagtcgtg ctcaaaagtt gcaaaaactg ctctgggtag atttagaaca tcggtatatc
    34681 aatggagtag aagtgcagcg agagttacat cgccgagggc gtagtcaacc aatgggggtg
    34741 gtgtttacta gcatgttagg cttcgagtat ctagttgatg aaaggttggg aagaagactt
    34801 ggtttggacg aattcggaga ggaagtgtat aaagtaggta caacacctca agtgtggctg
    34861 gataatgtag tcgctgagaa aaacggagca ttgatcttta attggtatgc cgttgaagcg
    34921 ctattcccgg aaggtttaat agataaaatg tttgaggctt attgtgattt gcttcagcag
    34981 ctagctacct cggacgaacc ttggatggaa acttacttcc aattattacc aactgcccag
    35041 ctagcactac aagcacaagt aaatcagacc actcaatctt tgcctgaagg gctcttgcat
    35101 ggcttgtttg ttgagaaagt aaaagttcaa ggtcaagaga tagctgtgat tagtccccag
    35161 aaaagcctaa cttatgaaga actgtatcaa cggtctcatc aattaggaga tggattacgt
    35221 aaattagaag tcaaaccgaa tgagctagta gccgtagtca tggaaaaagg ttgggaacag
    35281 gtagtagggg tattgggtat cttgatgtct ggtggagctt acctaccgat agaccctgca
    35341 ctacctcagg aacgccagtg gtatctactt gagcaagcag aagtcaaaca agtattgact
    35401 caaactcacc tcaaacagtc cctgagttgg cctgagggaa ttaactgctg gtctgtagat
    35461 agtgaagagc tagcagtaga aaatccgact cccttagaac cagtacaaac tccagaagat
    35521 ttagcctatg tgatttacac ttccggttct acaggtttac ccaagggtgt aatgatcgat
    35581 catcggggag ctgtaaatac aatcctagac attaatcaac ggtttgaagt cagagcatca
    35641 gacagggtat tggccttagc aaatttgaac tttgacctat cagtatacga catcttcggc
    35701 gtgctaggag caggaggaac tatagtgatg ccaccgccag aagcagccaa agaccctgct
    35761 tgctggatag aattaattga aacccatcaa gtgactttat ggaactcagt tcctcctttg
    35821 atgcagatgt tggtagaaca tttattcgga acttcaagag tgccagtaga gggtttgcga
    35881 gtggttatgc tgagtgggga ttggttacca gtagacttac cagaaaaaat ccagtctctg
    35941 tggcctaatg ttcaagttat gagtttaggt ggagcaacag aagcatcaat ctggtcaatt
    36001 ggttataaga ttgaaaaggt tgatcctaat tggaagagta ttccctacgg taaacccctg
    36061 ttgaatcaac gtttctatgt actcaatgaa ttgatggaag ctagaccagt ttgggtacct
    36121 ggacaacttt atattggagg tgtaggatta gctaagggat attggaaaaa tgaggaaaaa
    36181 accaaagcta gctttattac ccacccagtt actcaagaga gattatacaa aacaggagat
    36241 ttaggaagat atttacctga tggtaatatt gagtttttag gtagagagga cttccaagta
    36301 aaaatcaatg gttatcgtgt tgaactggga gaaattgaag cagcattaaa gccatttccg
    36361 ggaatgaagg aagcaattgt tactactata ggagattcag aacaaaacaa acgtttaatt
    36421 gcttatgctg tgctaaagca acagcctatt actactgaaa atcagataga agaacaagat
    36481 aaaattagcc aacttgatca ggaattaaat tcttgttctc aacagttgcg taagtaccta
    36541 aggcaaaaac taccagagta tatgattcct tctaagtatg ttattttgga agctttccca
    36601 ctaactgcta atggcaaaat agaccgtaaa cgattgccag aacctcaagt agaaactatg
    36661 accacaactg aatacatact acctcaaaca aaaatagagc aacaaattgc tgctgtttgg
    36721 cgagaggttc ttcagatgga aaaagtcgga attcacgaca atttatttga tatagggggc
    36781 aattctgtac atgctatccg agtgcatagc aaattgcaag aactattggg catagaactg
    36841 aaagtagttg acctatttac taaccctact gtaaattcct taagtcaata tctggatcag
    36901 attgataggt catcaggaac tatcaaaaat cgtggagatg agcgatctaa aaaaggtatt
    36961 gctaggaaaa aaaggggcaa ttttagaaaa agtatacgcc acaagaaata atttttttgc
    37021 gcaggattat atgctacaat aaacactggg gatagaaccg aagagagtag acctatttac
    37081 cgaccctacc ccttattcct tttggtaaat catcagaaac tggaaaaaaa atcctgggta
    37141 tgagcgatcc aaactaaggt attatagcgc tacgagcaag tcagaagtca gaagtcagaa
    37201 gtcagaagta atccctgact gagtttgaga atttagaagt gtactaacct atttgcgtag
    37261 tgctatacta gaaaattaaa gtggcaattt tagacaaagt tattaaggag actgataatg
    37321 atgaatcact tagaagaaaa cctgaacgat aatcaggata tagcaataat tggaatgtct
    37381 gggcgttgtc caggagcaaa agatattgaa cagttttggc aaaatattcg agatggagtt
    37441 gagtcaatat ccttatcctt tttttcagaa aaagaattgc tcaactctgg ggtagaaaaa
    37501 gagctaatca ataatcctaa ctacgtcagg gttggcagca ttcttcctaa catagatatg
    37561 tttgatgctg gtttctttaa ctgtagtact aaagaggctg aagaactaga tccgcaacaa
    37621 aggctatttc ttgaatgtgc ttgggaagta gtagagaagg ctggttataa tccatatacc
    37681 tatgaaggtg ctatcggggt ttatgctagc atgatccaga gtagttattt attgccaggt
    37741 cgtcaagaga gcttgaaccc tagcttatta ttacaacaat atctatcaaa taacctagat
    37801 tactttgcaa cgcgcgttgc ttacaagctg aatctaaaag gagtggtcta g
//
