BGC0002543 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002543 (Phialomyces arenicola)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	66,625	High	acrophiarin	NRPS:Type I

BGC0002543 - Region 1 - NRPS

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Location: 1 - 66,625 nt. (total: 66,625 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 66,626
Label		BGC0002543

Tailoring functions

Oxidoreductases: oxygenase

p450-1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

p450-2: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Ligases: ligase synthase

htyA: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

ligase: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

nrps: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002543.3	0.99	NRPS	acrophiarin	Phialomyces arenicola
BGC0002135.2	0.73	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001261.3	0.71	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001166.5	0.71	NRPS	HC-toxin	Alternaria jesenskae
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001240.4	0.69	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002543.3	0.99	NRPS	acrophiarin	Phialomyces arenicola
BGC0002135.2	0.73	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001261.3	0.71	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001166.5	0.71	NRPS	HC-toxin	Alternaria jesenskae
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001240.4	0.69	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 4738 - 66578:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Thr - X - X - X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

nrps: X - Thr - X - X - X - X

Search NORINE for peptide: strict or relaxed

AMP-binding (605..991): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVCEVSSIVK
Nearest Stachelhaus code(s):: dhOrn DVCEASSIVK (91% 8Å match); Orn DVCEASSIVK (88% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1692..2094): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAQTAVAIHK
Nearest Stachelhaus code(s):: Thr DAQTAVAIHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2786..3184): X

nrpys: Pro, 4OH-Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVSSATTVCK
Nearest Stachelhaus code(s):: Pro DVSSATTVCK (94% 8Å match); 4OH-Pro DVSSATTVCK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3878..4257): X

nrpys: ohHty

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGEAVGCIFK
Nearest Stachelhaus code(s):: ohHty DGEAVGCIFK (97% 8Å match); dohHty DGEAVGCIFK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4947..5346): X

nrpys: bOH-Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAQNIASINK
Nearest Stachelhaus code(s):: bOH-Gln DAQNIASINK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (6045..6443): X

nrpys: 3S-oh-4S-mePro, 3OH-Pro, 3S-oh-4S-mePro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DNTMITAMSK
Nearest Stachelhaus code(s):: 3S-oh-4S-mePro DNTMITAMSK (94% 8Å match); 3OH-Pro or 3S-oh-4S-mePro DNTMITAMSK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

ligase: X

AMP-binding (38..470): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GLLYVGGVIK
Nearest Stachelhaus code(s):: cycHexAla DLLSVGGVFK (35% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor