BGC0002544: amychelin A biosynthetic gene cluster from Amycolatopsis methanolica
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 39,399 nt. (total: 39,399 nt).
This entry is originally from NCBI GenBank MT001874.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002544
Short description amychelin A biosynthetic gene cluster from Amycolatopsis methanolica
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MT001874.1
1 - 39399
via
Compounds
  • amychelin A
  • amychelin B
Species Amycolatopsis methanolica [taxonomy]
References
Chemical products information
amychelin A Evidence:
Copy SMILES
Chemical database entries
NPAtlas
amychelin B Evidence:
Copy SMILES
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QIE08749.1
  • AMET_0593
 296 - 1234 (-) N-OH-Orn-formyltransferase
    copy AA seq
    copy Nt seq
    • QIE08741.1
    • AMET_0594
    		 1341 - 2660 (+) ornithine N-monooxygenase
      copy AA seq
      copy Nt seq
      • QIE08742.1
      • AMET_0595
      		 2657 - 3967 (+) salicylate synthase
        copy AA seq
        copy Nt seq
        • QIE08747.1
        • AMET_0596
        		 4017 - 5033 (-) transport system permease protein
          copy AA seq
          copy Nt seq
          • QIE08746.1
          • AMET_0597
          		 5030 - 6085 (-) transport system permease protein
            copy AA seq
            copy Nt seq
            • QIE08740.1
            • AMET_0598
            		 6309 - 7904 (-) salicylate-AMP ligase
              copy AA seq
              copy Nt seq
              • QIE08743.1
              • AMET_0599
              		 7984 - 9234 (+) major facilitator transporter
                copy AA seq
                copy Nt seq
                • QIE08750.1
                • AMET_0600
                		 9207 - 10010 (+) alpha/beta hydrolase
                  copy AA seq
                  copy Nt seq
                  • QIE08753.1
                  • AMET_0601
                  		 10064 - 10270 (+) mbtH-like protein
                    copy AA seq
                    copy Nt seq
                    • QIE08736.1
                    • AMET_0602
                    		 10273 - 21729 (+) non-ribosomal peptide synthetase
                      copy AA seq
                      copy Nt seq
                      • QIE08737.1
                      • AMET_0603
                      		 21722 - 28897 (+) non-ribosomal peptide synthetase
                        copy AA seq
                        copy Nt seq
                        • QIE08738.1
                        • AMET_0604
                        		 28891 - 32274 (+) non-ribosomal peptide synthetase
                          copy AA seq
                          copy Nt seq
                          • QIE08748.1
                          • AMET_0605
                          		 32663 - 33679 (-) iron compound ABC ransporter, periplasmic
                            copy AA seq
                            copy Nt seq
                            • QIE08739.1
                            • AMET_0606
                            		 33786 - 35906 (-) glycogen debranching enzyme
                              copy AA seq
                              copy Nt seq
                              • QIE08744.1
                              • AMET_0607
                              		 35903 - 37120 (-) glycosyl transferase, group 1
                                copy AA seq
                                copy Nt seq
                                • QIE08745.1
                                • AMET_0608
                                		 37170 - 38231 (-) MFS transporter
                                  copy AA seq
                                  copy Nt seq
                                  • QIE08752.1
                                  • AMET_0609
                                  		 38183 - 38518 (-) Drug resistance transporter, EmrB/QacA
                                    copy AA seq
                                    copy Nt seq
                                    • QIE08751.1
                                    • AMET_0610
                                    		 38597 - 39235 (+) TetR family transcriptional regulator
                                      copy AA seq
                                      copy Nt seq
                                      Biosynthesis information
                                      Annotation changelog

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-10-07
                                      Added chemical structures for compounds: amychelin B, amychelin A.
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-10-07
                                      Added NPAtlas links to compounds: amychelin B, amychelin A.
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Entry added
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      Detailed domain annotation
                                      Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                      A domain glossary is available here, and an explanation of the visualisation is available here.
                                      Selected features only
                                      Show module domains
                                      Similar known gene clusters from MIBiG 4.0
                                      Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                      Click on reference genes to show details of similarities to genes within the current region.
                                      Click on an accession to open that entry in the MiBIG database.