LOCUS       BGC0002547             20186 bp    DNA     linear   BCT 13-JAN-2020
DEFINITION  Streptomyces youssoufiensis strain OUC6819 youssoufenes biosynthetic
            gene cluster, complete sequence.
ACCESSION   BGC0002547
VERSION     BGC0002547
KEYWORDS    .
SOURCE      Streptomyces youssoufiensis
  ORGANISM  Streptomyces youssoufiensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 20186)
  AUTHORS   Li,H., Liu,J., Deng,Z., Li,T., Liu,Z., Che,Q. and Li,W.
  TITLE     Genetic Manipulation of an Aminotransferase Family Gene dtlA
            Activates Youssoufenes in Marine-Derived Streptomyces youssoufiensis
  JOURNAL   Org. Lett. (2019) In press
REFERENCE   2  (bases 1 to 20186)
  AUTHORS   Li,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2019) School of Medicine and Pharmacy, Ocean
            University of China, Shinan District, Qingdao, Shandong 266003,
            China
COMMENT     ##Assembly-Data-START##
            Sequencing Technology :: Sanger dideoxy sequencing
            ##Assembly-Data-END##
            ##antiSMASH-Data-START##
            Version               :: False
            Run date              :: 2025-08-15 22:06:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start           :: 0
            Orig. end             :: 20186
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..20186
                     /db_xref="taxon:654447"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces youssoufiensis"
                     /strain="OUC6819"
     region          1..20186
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /subregion_numbers="1"
                     /tool="antismash"
     subregion       1..20186
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="PKS"
                     /subregion_number="1"
                     /tool="antismash"
     cand_cluster    1..20186
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20186
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[3135:4347](+)"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3136..4347
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     gene            506..766
                     /gene="ysfA"
     CDS             506..766
                     /NRPS_PKS="Domain: PP-binding (10-65). E-value: 7.1e-16.
                     Score: 50.5. Matches aSDomain:
                     nrpspksdomains_ysfA_PP-binding.1"
                     /codon_start=1
                     /gene="ysfA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl carrier protein"
                     /product="YsfA"
                     /protein_id="QHB92588.1"
                     /sec_met_domain="PP-binding (E-value: 2e-16, bitscore:
                     50.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTATKQEQLDEIREIVAEVLELEPEEISETSHFIEEHEADSLRA
                     IEILARLEKKYKVEIPQSELPKMINLTEVYNVLAEHAGWQG"
     misc_feature    506..20109
                     /note="youssoufenes biosynthetic gene cluster"
     aSDomain        536..700
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ysfA_PP-binding.1"
                     /evalue="7.10E-16"
                     /label="ysfA_PP-binding.1"
                     /locus_tag="ysfA"
                     /protein_end="65"
                     /protein_start="10"
                     /score="50.5"
                     /tool="antismash"
                     /translation="DEIREIVAEVLELEPEEISETSHFIEEHEADSLRAIEILARLEKK
                     YKVEIPQSEL"
     gene            772..1983
                     /gene="ysfB"
     CDS             772..1983
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (81-400). E-value:
                     2.4e-56. Score: 183.4. Matches aSDomain:
                     nrpspksdomains_ysfB_PKS_KS.1"
                     /codon_start=1
                     /gene="ysfB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) itr_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) tra_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) hyb_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ene_KS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /note="3-oxoacyl-ACP synthase"
                     /product="YsfB"
                     /protein_id="QHB92589.1"
                     /sec_met_domain="t2fas (E-value: 1.4e-101, bitscore: 330.3,
                     seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 2e-38, bitscore:
                     122.5, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 6.9e-54, bitscore: 173.3,
                     seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 3.3e-45, bitscore: 144.8,
                     seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 3.8e-44, bitscore: 141.3,
                     seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="mod_KS (E-value: 6.5e-47, bitscore: 150.4,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="ene_KS (E-value: 6.7e-35, bitscore: 110.6,
                     seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLRRVVITGLGPVSSIGIGASAYSEGLREGVNGVSPIACFDPTG
                     FPYIMAGEVHAFRPEDMVRRLSVDEWGRTSLFAASAARLAVADAGIDEDELAASRAGSS
                     MGTTGGESQVLEKLTEDSLTAGMGGLDAGLVRQVGSARLSQAVNRELRLTGDAVTLSTA
                     CSASNYALGYAYDLIRTGEADYMIAGGADSVGRWSHAGFYRLGALTEKACSPFDANRSG
                     IITGEGGAAMFLESLESAQARGAHIHAEVLGYGLNCDANHMVAPNRDSIAECMRIAHAN
                     SGVKAEEVDYICAHGTGTPANDFVEASAVVDVFGENPPPISSTKSMLGHTMGAASGLGA
                     IASVLGIAGSFLPPTINFNTPDPDMPKIDPVPNKARAADVRIAQVNGFAFGGNNAIVML
                     GRPE"
     aSDomain        1015..1971
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ysfB_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.40E-56"
                     /label="ysfB_PKS_KS.1"
                     /locus_tag="ysfB"
                     /protein_end="400"
                     /protein_start="81"
                     /score="183.4"
                     /tool="antismash"
                     /translation="ARLAVADAGIDEDELAASRAGSSMGTTGGESQVLEKLTEDSLTAG
                     MGGLDAGLVRQVGSARLSQAVNRELRLTGDAVTLSTACSASNYALGYAYDLIRTGEADY
                     MIAGGADSVGRWSHAGFYRLGALTEKACSPFDANRSGIITGEGGAAMFLESLESAQARG
                     AHIHAEVLGYGLNCDANHMVAPNRDSIAECMRIAHANSGVKAEEVDYICAHGTGTPAND
                     FVEASAVVDVFGENPPPISSTKSMLGHTMGAASGLGAIASVLGIAGSFLPPTINFNTPD
                     PDMPKIDPVPNKARAADVRIAQVNGFAFGGNNAIVMLG"
     gene            1980..3152
                     /gene="ysfC"
     CDS             1980..3152
                     /codon_start=1
                     /gene="ysfC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /note="3-oxoacyl-ACP synthase"
                     /product="YsfC"
                     /protein_id="QHB92590.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 3.4e-16, bitscore:
                     49.7, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="t2fas (E-value: 1e-24, bitscore: 77.1,
                     seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTATAPATAPAKPGTGSTALAITGFGVLSGAGIGPEALAAALAA
                     PAAPVDVSEMFEEELPRDDAHALVDFKVRDHLGRKGTSFFDRSTSLGMVACKEALADSD
                     LEIDDDNRARIGITLGTTAGSAKSTSDYSKDTFIQDRPYLVNPLLFPNAVMNCAAGQSG
                     IKFGLQGPNATIAGGPMAMLNVLRYTRNLINCGYADALLAGAVEEFSPQESWAVHYAQS
                     VYGGDAAPGEGAAVFVVENADAVRAAGRTPDAEVLSVEVGVFDPPGPDGEFSRGLGLCI
                     SRALERAGVTAADITAVATAANGMTLLDEAEERAIGAIVGADVARLRVKDATGEAFSAS
                     GAFQLAALLARHRAEPARDGELSLITTRSAEGAAGAAVVRGWSRAGGDHG"
     gene            3136..4347
                     /gene="ysfD"
     CDS             3136..4347
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (155-400). E-value:
                     7.2e-42. Score: 135.7. Matches aSDomain:
                     nrpspksdomains_ysfD_PKS_KS.1"
                     /codon_start=1
                     /gene="ysfD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) itr_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) tra_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ene_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) hyb_KS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /note="beta-ketoacyl synthase"
                     /product="YsfD"
                     /protein_id="QHB92591.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 3.6e-19, bitscore:
                     59.4, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 1.2e-42, bitscore: 136.3,
                     seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 2e-35, bitscore: 112.6,
                     seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="APE_KS2 (E-value: 6.1e-51, bitscore:
                     163.7, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="ene_KS (E-value: 4.9e-31, bitscore: 97.8,
                     seeds: 19, tool: rule-based-clusters)"
                     /sec_met_domain="mod_KS (E-value: 2.3e-34, bitscore: 109.0,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 3.3e-32, bitscore: 101.9,
                     seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAITGSSMVSCHGDLDATFDALVAGRSGASPLRAGDPAKLNVTHG
                     YGIDDATERAYRETVAAAGSASGAAGGAAADEAYGIGDDVRLSGRWLAQAVAGALAEAG
                     VDSRTSRVAVIVGTGLRELRAVEQWHGDDAALRLAQTHFNEAVRSVAPGVTEVHTLANA
                     CAASGYALALAADLLELGEADAVVAAGCDTFTESMLTMIGRVGTTTAETVRPFDTDRDG
                     VLLGEGAAAVVLELPSSKPAFGLIRGVGIGCDAFHETAPDPNGILATMREAHQRAGIEA
                     GDVDLVVAHGTSTALNDPTEATALAELFGDIAPADAPAVTGIKGAIGHTSGGAALMSVL
                     VACQAMRKGTVPPVTGLRTAIPEAEKLALVIGEPLAARPRIAQVNAFGFGGVNAVTIVE
                     AVDA"
     aSDomain        3601..4335
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ysfD_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="7.20E-42"
                     /label="ysfD_PKS_KS.1"
                     /locus_tag="ysfD"
                     /protein_end="400"
                     /protein_start="155"
                     /score="135.7"
                     /tool="antismash"
                     /translation="EVHTLANACAASGYALALAADLLELGEADAVVAAGCDTFTESMLT
                     MIGRVGTTTAETVRPFDTDRDGVLLGEGAAAVVLELPSSKPAFGLIRGVGIGCDAFHET
                     APDPNGILATMREAHQRAGIEAGDVDLVVAHGTSTALNDPTEATALAELFGDIAPADAP
                     AVTGIKGAIGHTSGGAALMSVLVACQAMRKGTVPPVTGLRTAIPEAEKLALVIGEPLAA
                     RPRIAQVNAFGFGGVNAVTIVEA"
     gene            4340..5254
                     /gene="ysfE"
     CDS             4340..5254
                     /codon_start=1
                     /gene="ysfE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_kind="biosynthetic-additional"
                     /note="beta-ketoacyl synthase"
                     /product="YsfE"
                     /protein_id="QHB92592.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.7e-15, bitscore:
                     47.4, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPESQIAHRTADRPLAIAGWAVHVPGLSAADLPGSPDEAACGPED
                     AKDVLGRKGLLGKEPSTRLALCAVHRALGLPAGKLAEPLPYAPRTAVVVASNLGNVETV
                     TTVLDDMRSRGGNVVSPLDAPNASSNVIASSIAIKYGFNGPNLAVCSGATAGLDAVRLA
                     RLLLLSGRAERAVVVGVEPADPVARALAALRPGDPGELIAGAGCVLLGPPGAWPTDTGI
                     TVGPVVRHASDPGTAEGQPAVGELYGAAGVVRLAAAAAVLAGGASGDDDAAGLTVHCGD
                     ADDAWLTVDVTRAGDRQEAGAAA"
     gene            5251..7038
                     /gene="ysfF"
     CDS             5251..7038
                     /codon_start=1
                     /gene="ysfF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /note="thioesterase"
                     /product="YsfF"
                     /protein_id="QHB92593.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.3e-12, bitscore:
                     37.2, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="4HBT_2 (E-value: 3.8e-09, bitscore: 27.2,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQDGWTLVATEGPVQVWRGPGSGPPIVAAHGMEDGWKSWRTVL
                     GALPGYTPYSLHLPWCAGTDYAWTADGSPKEWLRRALALLPEPPRALFGHSFGANAILA
                     HLAVLPQQDGLAAELDAVVLVAPFYRPVGFPLSDQLRLRSVAALRRVLVEGLRVTLGPR
                     AARMDREVLALMECKLLDRAVPSAFPVFYEAFEDSGHLDLSRVTVPTLIYVGPGDEGLT
                     PMRAKALADAVPGATLLSRRGYGHFCHIDRAEEMTAEVADFLRDPRSAADSSEGGTTVT
                     ELLDGQPTSYVGQPRYEGANIRTWIGFKHFMYLVEEGVLQYFRDRGVGARDIYHRYGLG
                     LEIVDSSVQLPVALEAEEQVYATVVSGKPKPGQGAPFNVSLTVEREGETVTVLKGKVQV
                     ALVAVKDGSGSEPVPAILEPYVVPDVAALTNSAKATLEIPAGASVQDVLAPEGSGAYLW
                     DWRAPYYYCHFSDRLQHSAYIRTMEEVVDRFLADRGLAVGTLLDERGWIPVVSRARVQM
                     LSDIYMEETVHTVFKVEDILKDTMYTARMDCYVRRGDTLERAATGTIMHGYAISRGEKA
                     GTVAVLDEATQATLLGGAA"
     gene            7035..7676
                     /gene="ysfG"
     CDS             7035..7676
                     /codon_start=1
                     /gene="ysfG"
                     /note="isomerase"
                     /product="YsfG"
                     /protein_id="QHB92594.1"
                     /transl_table=11
                     /translation="MRKPPRLYFSLRSPFSWMAVRQLEERIPNAQDLIEYIPFFEPDAT
                     SSKALEEQGGEFHYVAMSKAKHLYILNDTKRLSQKYGYPMKWPIDKGDEWWELPHLAWI
                     KAKELGVHREYYTAAMAARWERGEDICNRDTLRQVCLDAGLDAEALVNAPEEAHIREAG
                     VQALMRVYEDDVFGVPYFKVGRHRFWGLDRLDDFVTTLEEALATAASKAA"
     gene            7879..8637
                     /gene="ysfH"
     CDS             7879..8637
                     /NRPS_PKS="Domain: PKS_KR (13-174). E-value: 1.5e-25.
                     Score: 82.1. Matches aSDomain:
                     nrpspksdomains_ysfH_PKS_KR.1"
                     /codon_start=1
                     /gene="ysfH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /note="reductase"
                     /product="YsfH"
                     /protein_id="QHB92595.1"
                     /sec_met_domain="adh_short (E-value: 2.2e-45, bitscore:
                     145.0, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 6.4e-33, bitscore:
                     104.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTETDTETQRPMAIVTGGSRGIGRACAVQLATDGYDVAFCYRSGN
                     DAAAETEKLIREQGAQVYHAPCDVADYDAVQAFIKDAKAALGPVSVLVNSAGIVKDNPM
                     VLMPHEDWQAVIDTNLNGTFNFCRSVVFDFMKRKEGVIVNMSSISGVYGHATQTNYSAS
                     KAGIQGMSASLAKEVAGYGIRVNVVAPGFIETDMTEALPEKLRAQALKSIPMKRYGGAD
                     EVAYLVSFLVSDRAKYITGEVIEVDGGVSL"
     CDS_motif       7918..7974
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ysfH_0001"
                     /evalue="2.00E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ysfH"
                     /protein_end="32"
                     /protein_start="13"
                     /score="14.0"
                     /tool="antismash"
                     /translation="IVTGGSRGIGRACAVQLAT"
     aSDomain        7918..8400
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ysfH_PKS_KR.1"
                     /evalue="1.50E-25"
                     /label="ysfH_PKS_KR.1"
                     /locus_tag="ysfH"
                     /protein_end="174"
                     /protein_start="13"
                     /score="82.1"
                     /tool="antismash"
                     /translation="IVTGGSRGIGRACAVQLATDGYDVAFCYRSGNDAAAETEKLIREQ
                     GAQVYHAPCDVADYDAVQAFIKDAKAALGPVSVLVNSAGIVKDNPMVLMPHEDWQAVID
                     TNLNGTFNFCRSVVFDFMKRKEGVIVNMSSISGVYGHATQTNYSASKAGIQGMSASL"
     CDS_motif       8308..8364
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ysfH_0002"
                     /evalue="3.70E-06"
                     /label="PKSI-KR_m4"
                     /locus_tag="ysfH"
                     /protein_end="162"
                     /protein_start="143"
                     /score="19.4"
                     /tool="antismash"
                     /translation="NMSSISGVYGHATQTNYSA"
     gene            9217..9693
                     /gene="ysfI"
     CDS             9217..9693
                     /codon_start=1
                     /gene="ysfI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1270: UDP-3-O-[3-hydroxymyristoyl]
                     N-acetylglucosamine"
                     /gene_kind="biosynthetic-additional"
                     /note="dehydratase"
                     /product="YsfI"
                     /protein_id="QHB92596.1"
                     /transl_table=11
                     /translation="MIDYAELRELIPHAHPILLVDKVLDIAPPDRITTAKTVTGSEPCY
                     AGIAPGAPTRAFAYPPALLMESWGQGGALLWMQHVQSQARERNGGLILAAARGMEFRRP
                     VYPGDTLRHEVRIDQFVGDNVIMSGESYVDGELASKVDYAIAVMRPSNELTWAS"
     gene            9693..10976
                     /gene="ysfJ"
     CDS             9693..10976
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (73-391). E-value:
                     6e-49. Score: 159.0. Matches aSDomain:
                     nrpspksdomains_ysfJ_PKS_KS.1"
                     /codon_start=1
                     /gene="ysfJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) itr_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) hyb_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) tra_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ene_KS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /note="3-oxoacyl-ACP synthase"
                     /product="YsfJ"
                     /protein_id="QHB92597.1"
                     /sec_met_domain="t2fas (E-value: 1.6e-79, bitscore: 257.7,
                     seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.1e-37, bitscore:
                     120.1, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 3.5e-48, bitscore: 154.5,
                     seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 2.1e-39, bitscore: 125.6,
                     seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 8.7e-38, bitscore: 120.3,
                     seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="mod_KS (E-value: 1.4e-38, bitscore: 122.9,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="ene_KS (E-value: 5.8e-31, bitscore: 97.6,
                     seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDVVITGLGVVSPLGNDPGEYWERLLRGEVPVRPLVAPGTAVD
                     GIHTYPVTDTPQPAPHPGDQPGRASGFALAAAGDALRDAGLADAGPAVLDGVGMVVGTG
                     NGDSDLREAERDGRRELSGLQWYPYDTAGLLAERLALHGPSLTVSTACAAGAYAVAMGA
                     EMIRTGEADVVLVGGTEAVSRPAVGAFLRLGAAEPGPCRPFDTDRAGTVYGEGAAFLVL
                     ESAAHARSRGASPYARVLDSGWSCDAFHETAPDPLGSQALRAVREALQRSGLDRDDIGA
                     VLCHGTGTPANDAVESRTTAALLGARTPEVPVTAIKASLGHSGGAAGAFSCLTAALVLR
                     DGAVPPVGTLRELDPACELRVVREAPQASAGSAVLVNAYAFGGNNISVALAALDPAAAA
                     EADPGAATETHGWAARRPRPVPLREGAA"
     aSDomain        9912..10865
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ysfJ_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="6.00E-49"
                     /label="ysfJ_PKS_KS.1"
                     /locus_tag="ysfJ"
                     /protein_end="391"
                     /protein_start="73"
                     /score="159.0"
                     /tool="antismash"
                     /translation="LAAAGDALRDAGLADAGPAVLDGVGMVVGTGNGDSDLREAERDGR
                     RELSGLQWYPYDTAGLLAERLALHGPSLTVSTACAAGAYAVAMGAEMIRTGEADVVLVG
                     GTEAVSRPAVGAFLRLGAAEPGPCRPFDTDRAGTVYGEGAAFLVLESAAHARSRGASPY
                     ARVLDSGWSCDAFHETAPDPLGSQALRAVREALQRSGLDRDDIGAVLCHGTGTPANDAV
                     ESRTTAALLGARTPEVPVTAIKASLGHSGGAAGAFSCLTAALVLRDGAVPPVGTLRELD
                     PACELRVVREAPQASAGSAVLVNAYAFGGNNISVALA"
     CDS_motif       10119..10166
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ysfJ_0001"
                     /evalue="1.00E-03"
                     /label="PKSI-KS_m3"
                     /locus_tag="ysfJ"
                     /protein_end="158"
                     /protein_start="142"
                     /score="11.7"
                     /tool="antismash"
                     /translation="GPSLTVSTACAAGAYA"
     gene            10973..12034
                     /gene="ysfK"
     CDS             10973..12034
                     /codon_start=1
                     /gene="ysfK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_kind="biosynthetic-additional"
                     /note="3-oxoacyl-ACP synthase"
                     /product="YsfK"
                     /protein_id="QHB92598.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.5e-11, bitscore:
                     34.5, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVTTTTPVAITGVGVISRPAIGAQELARAADLWHSEPSDPTDPT
                     NNERPWAIAELDNFAPAEFLGKRGWRFLPEATRVALAAVQLALAHANEAADDATEHAPE
                     RVGVALGTNFAVDAVVDRIDRALLAEGIAGISPVECPNFSVNVPAGRLGIAHGLRAFNI
                     TLVNLLTAGLESALVGARAMADDRADAVLVGAVEGRPPAAARTVTGPGVDAAGACLLHL
                     ERPERAAERGAAVHAQLTGGSRRTVPGNPAAAQRVLAAALDALGAPPGVLHLSLPAEGG
                     EHVAQAAEDWAKARGAGTGLTVTTGAPQGSATPVLGLAQHLVRGVHESAVVGALGPRGN
                     LTLLRIEPPRSRA"
     gene            12031..12840
                     /gene="ysfL"
     CDS             12031..12840
                     /codon_start=1
                     /gene="ysfL"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /note="hydrolase"
                     /product="YsfL"
                     /protein_id="QHB92599.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.1e-13, bitscore:
                     42.4, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPESGPAPVKASLLYGEELAVHRFAELPAAALVHGLEDDWSSYT
                     KLSQLLSGRFRSFPLDMPWRSGGTYRWRARATSGQWIEGGLQMMPEPVSVLIAHSMGAN
                     SVLQWLASGANPKLDALILLSPFYWSPTQPVDWAIFDGFRQQFAAVMTAGLQTRLGPRA
                     HTMDPDIFNTMVRKMLEKMGPQAFLALFDQYSAASSLALSHVSVPTLVIGSPNDPGMLG
                     DRADALQADMPSAELCMDPRFSHFCHVEQAQEVADLIIAFVDRQRAG"
     gene            12870..14456
                     /gene="ysfM"
     CDS             12870..14456
                     /codon_start=1
                     /gene="ysfM"
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /note="MFS transporter"
                     /product="YsfM"
                     /protein_id="QHB92600.1"
                     /transl_table=11
                     /translation="MSGNTLHLRALPPRNKPGLTLLAALLGLFIALLDVTVVTVAMPTI
                     GEDLDATFDDLEWVANAYMLALAVLIVTAGRLGDLYGQRVIYVIGVVIFLAGSVLCAAA
                     GEITLLGAEHITTLHVGRVVQGVGGAVVMPLTLAIVYSSFEGKARAKGIMMWGAVGGLA
                     TALGPLIGGLLVDHAGWEWIFLINVPIGAVVIFAALAGMGADQRRATSGNSIDLPGLLT
                     LSASLLCINLALINGNSWGWTSAKVLGLLAGGILLLAGFLAVEARSKAPIMDLGWFRRP
                     SFGGSIATSFLLGAGMFSVIFYLSIYLQTGLDLSAQETGVRLLPMTLMLMIGAPVGGRI
                     VAKAGVRKALIFAMTLMAVGIALYTLADPKGDSGSWTLLLPGMLLTGLAMGVAMPVASE
                     LTISSAPQDQVGVAASAGTMIRQVGNAVGIAIMGALMSNRTDAATEEMIDLQRKGEATA
                     EAAAALQQKAVTEGMENGAWYAAAITLVGAVLVVLFVRDTQSPTGTSAAPPAPPRPRPD
                     DTMRLSKLPSA"
     gene            14467..15534
                     /gene="ysfN"
     CDS             14467..15534
                     /NRPS_PKS="Domain: PKS_AT (41-331). E-value: 6.5e-65.
                     Score: 211.3. Matches aSDomain:
                     nrpspksdomains_ysfN_PKS_AT.1"
                     /codon_start=1
                     /gene="ysfN"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic-additional"
                     /note="acyltransferase"
                     /product="YsfN"
                     /protein_id="QHB92601.1"
                     /sec_met_domain="PKS_AT (E-value: 1.8e-65, bitscore: 211.3,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHTDTQHPAAPASPAAPAAATAPAASGASDTEGQRGKTAFLFPG
                     QGSQKVGMGLDVIAARPDLVETYYQQADDILGIPLSKLCWEGPEDALRDTAITQPAVFL
                     TSLVTLDLLGDRGVHPDVVAGHSLGEYTALVAAGVLDWRDALRLVRRRGQLMAGVNERV
                     PGAMAAVLGLDLATVEEICAEVAAETGQVAEVANDNEPGQSVVSGEAGAIEKVREAAQR
                     AGAVKAIALPVGAPFHCALMRGIEEEFAAELDQVTFREPSTPVVSGVTADYATSARGIT
                     DALRRQLAGRVRWTGSVQLMAASGVTHFVEVGPGKVLSGLCRRIVPELTSYTTNDERRL
                     AKTLDALAPTAAVAA"
     CDS_motif       14587..14634
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ysfN_0001"
                     /evalue="1.40E-06"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="ysfN"
                     /protein_end="56"
                     /protein_start="40"
                     /score="20.5"
                     /tool="antismash"
                     /translation="FLFPGQGSQKVGMGLD"
     aSDomain        14590..15459
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ysfN_PKS_AT.1"
                     /evalue="6.50E-65"
                     /label="ysfN_PKS_AT.1"
                     /locus_tag="ysfN"
                     /protein_end="331"
                     /protein_start="41"
                     /score="211.3"
                     /tool="antismash"
                     /translation="LFPGQGSQKVGMGLDVIAARPDLVETYYQQADDILGIPLSKLCWE
                     GPEDALRDTAITQPAVFLTSLVTLDLLGDRGVHPDVVAGHSLGEYTALVAAGVLDWRDA
                     LRLVRRRGQLMAGVNERVPGAMAAVLGLDLATVEEICAEVAAETGQVAEVANDNEPGQS
                     VVSGEAGAIEKVREAAQRAGAVKAIALPVGAPFHCALMRGIEEEFAAELDQVTFREPST
                     PVVSGVTADYATSARGITDALRRQLAGRVRWTGSVQLMAASGVTHFVEVGPGKVLSGLC
                     RRIVPELTS"
     CDS_motif       14815..14937
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ysfN_0002"
                     /evalue="1.10E-20"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="ysfN"
                     /protein_end="157"
                     /protein_start="116"
                     /score="65.8"
                     /tool="antismash"
                     /translation="GVHPDVVAGHSLGEYTALVAAGVLDWRDALRLVRRRGQLMA"
     gene            15564..17171
                     /gene="ysfO"
     CDS             15564..17171
                     /codon_start=1
                     /gene="ysfO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl-CoA carboxylase"
                     /product="YsfO"
                     /protein_id="QHB92602.1"
                     /transl_table=11
                     /translation="MSITDDRRITTDDLPEDPSTGGLPEQLLKLRELKEGIYAGDPAAT
                     ERQHAKNKLTARERIDLLLDEGSFHEIETLRRHRASGFGLEHKKPHTDGVITGWGTVHG
                     RTVFVYAHDFRIFGGALGEAHAQKIHKLMDLAESAGAPLVSLNDGAGARIQEGVTALAG
                     YGGIFQRNTRCSGVIPQISVMLGPCAGGAAYSPALTDFVFMVRESSQMFITGPDVVRAV
                     TGEEISQNGLGGADVHASVSGVAAFAYDDEESCLEEVRYLLSMLPQNNRETAPVEETED
                     PADRSTDALLDLVPGDPNRSYDMRQVIEEIVDDHDFFEVQPTWATNIICALARLDGHVV
                     GIVANQPASLAGVLDIHASEKAARFVQTCDAFNIPLVSLVDVPGFLPGVDQEHGGIIRH
                     GAKLLYAYCNATVPRVQVILRKAYGGAYIVMDSRSIGVDVSLAWPSNEIAVMGAEGAAN
                     VIFRREIAAADDPDAVRQQKIKEYQSELMHPYYAAERGLVDDVIDPRETRSALISSLAM
                     LRTKHANLPSRKHGNPPV"
     gene            17449..19446
                     /gene="ysfP"
     CDS             17449..19446
                     /codon_start=1
                     /gene="ysfP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl-CoA carboxylase"
                     /product="YsfP"
                     /protein_id="QHB92603.1"
                     /sec_met_domain="ATP-grasp (E-value: 5.7e-10, bitscore:
                     29.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGALPKAPGTRAAAAGGQPAAAGTPDGTRPLTKVTTLAAPSAEP
                     THPAWVTRSVGKGKRRPMRKVLIANRGEIAVRVARACRDAGIGSVAVYADPDRDALHVR
                     VADEAYALGGDTPATSYLDMGKVLAAAAESGADAVHPGYGFLSENADFAQAVLDAGLTW
                     IGPPPQAIRDLGDKVAARHIAQRAGAPLVAGTADPVSGADEVVAFAREHGLPIAIKAAF
                     GGGGRGLKVARSLDEVAELYDSAVREAVAAFGRGECFVERYLDRPRHVETQCLADQHGN
                     VVVVSTRDCSLQRRHQKLVEEAPAPFLSEAQNAELYRASKAILREAGYVGAGTCEFLVG
                     QDGTISFLEVNTRLQVEHPVTEEVTGLDLVREMFRIADGEELGYEDPPVRGHSFEFRVN
                     GEDPGRGFLPAPGVVTRFAGPSGPGVRLDAGVESGSVIGPAWDSLLAKLIVTGASRRQA
                     LERAARALGEFEVEGMATALPFHRAVVADPAFAPERSGSVDAFRVHTRWIETEFVNDIP
                     PFVPGEVAGEDGEGEGAGRETVVVEVGGKRLEVSLPASLGFAPTTGNGGGAAGGASKTK
                     RKKTKAAGSAATGDALASPMQGTIVKAAVEEGQRVEEGDLIVVLEAMKMEQPLNAHRAG
                     IVHGLEAAVGGSVSAGAVICQIKDEQLATV"
     gene            19603..20109
                     /gene="ysfQ"
     CDS             19603..20109
                     /codon_start=1
                     /gene="ysfQ"
                     /note="unknown"
                     /product="YsfQ"
                     /protein_id="QHB92604.1"
                     /transl_table=11
                     /translation="MARGPVVRKSAEAVSPSGEKSLGGVDHVDTVAVDVAPGTTPAEFA
                     KAMMSSPPKWVLVLMTVRDKIVKPFGLRGGPVQEPGEVAPGAKLGPMRVIDVSADEVVA
                     GKDDKHLSYRVIFVVRDGAHGTEGACSTVVRYNRPAGKRYFAAIRPFHNTIMANFAKRG
                     GATLG"
ORIGIN
        1 gcaccgggcg cagcccactg acccaccctc cagcaccacc cctcatacga cccgagcgtc
       61 agccccgagc gccagtgccc agcgccggtc cggccggaag ccgccgtcac agcggtgagc
      121 accggcaggg ccggcgccgg tgcgttcggg agtcggcccg gcgccgatgc ctcgcgtacg
      181 aagaaccgct cccgcccccc ttcgcgacaa ggcgaggcaa tgccggggac tatgaatacg
      241 gcggcggtcc gagagatgtc actgaaccgc aacagatatc tcggttctgt tatttgcgag
      301 taacgactta ttcattattg aagagccttt gtggcgtggc gcacaacagg ccccaactgg
      361 ctcaccgaaa aagcgctgtt gggctatctg tgaacaccca tcgatggtgg ctcagacgcc
      421 ttgtggctgc ctaacattga agtgtcggaa cgcgagagat cgacgttctg aattcccctc
      481 agaagcccga gaaaggtgtt cataaatgtc gaccgccacc aagcaggagc agctcgacga
      541 gatccgcgaa atcgtcgcgg aggtgctgga gcttgagccc gaggaaatct cggagaccag
      601 ccacttcatc gaggagcacg aggccgactc gctgcgcgcg atcgagatcc tcgcccgcct
      661 ggagaagaag tacaaggtgg agatcccgca gtcggaactc cccaagatga tcaacctcac
      721 cgaggtctac aacgtgctcg ccgagcacgc tggttggcag ggctgagcct tatgtcactc
      781 cgacgggtag tcatcaccgg cctggggccc gtgtcgagca tcgggatcgg ggcgtccgcg
      841 tacagcgagg ggttgcgcga aggcgtcaac ggtgtctcgc cgatcgcctg cttcgacccc
      901 accggtttcc cctacatcat ggccggcgaa gtccacgcct tccggccaga ggacatggtc
      961 cggcggctgt ctgtcgacga gtggggccgt accagcctct tcgcggcgtc cgcggcccgc
     1021 ctcgcggtcg cggacgccgg gatcgacgaa gacgaactgg ccgcctcccg cgccggatcg
     1081 agcatgggca ccaccggcgg cgagtcgcag gtgctcgaaa agctcaccga ggactcgctc
     1141 accgcgggca tgggcggctt ggacgcgggc ctggtacgcc aggtcggcag cgcgcggctc
     1201 tcgcaggccg tcaaccgcga actgcgcctg accggcgacg ccgtgacctt gtccaccgcc
     1261 tgttcggcca gcaactacgc gcttggttac gcgtacgacc tgatccgcac cggcgaggcg
     1321 gactacatga tcgcgggcgg cgcggactcg gtcggccgct ggtcgcacgc cgggttctac
     1381 cggctcggcg cgctcaccga gaaggcgtgc tcgccctttg acgcgaaccg ctccggcatc
     1441 atcaccggtg agggcggcgc ggcgatgttc ctggagtcgc tggagtcggc ccaggcgcgc
     1501 ggcgcgcaca tccacgccga ggtcctcggc tacgggctca actgcgacgc caaccacatg
     1561 gtcgccccga atcgggacag catcgccgag tgcatgcgca tcgcgcacgc caactcgggt
     1621 gtcaaggccg aagaggtcga ctacatctgc gcccacggca ccggcacgcc ggccaacgac
     1681 ttcgtcgagg ccagcgccgt cgtggatgtc ttcggcgaga acccgccgcc gatcagctcc
     1741 accaagtcga tgctcggcca caccatgggc gccgcatccg gcctcggggc gatcgcatcg
     1801 gtgctcggca tcgcgggctc gttcctgccg cccaccatca acttcaacac cccggacccg
     1861 gacatgccca agatcgaccc cgtgccgaac aaggcacgcg ccgctgatgt gcggatcgcg
     1921 caggtcaacg gcttcgcgtt cggtggcaac aacgccatcg tgatgctggg gaggcccgag
     1981 tgagcaccgc aaccgcaccc gctacggcgc ccgcgaagcc cggcaccggc tccaccgcgc
     2041 tggccatcac cggcttcggc gtgctctccg gcgccggcat cggccccgag gcgctggccg
     2101 cggcactcgc cgcgccggcc gccccggtgg atgtcagcga gatgttcgag gaggagctgc
     2161 cgcgcgacga cgcgcacgcg ctggtggact tcaaggtccg cgaccacctc ggccgcaagg
     2221 gcacctcgtt cttcgaccgc tccacctcgc tgggcatggt cgcctgcaag gaggcgctgg
     2281 ccgacagcga cctggagatc gacgacgaca accgggcccg catcggcatc acgctcggca
     2341 ccaccgccgg cagcgccaag tcgaccagcg actacagcaa ggacacgttc atccaggacc
     2401 gtccttacct ggtcaacccg ctgctgttcc cgaacgcggt gatgaactgc gcggccggcc
     2461 agtcgggcat caagttcggt ctgcagggcc ccaacgccac catcgccggt ggcccgatgg
     2521 ccatgctgaa cgtgctgcgc tacacccgca acctcatcaa ctgtggttac gcggacgcgc
     2581 tgttggccgg cgcggtcgag gagttcagcc cgcaggagtc gtgggccgtg cactacgcgc
     2641 agtccgtcta cggcggcgac gcggcacccg gcgagggcgc ggccgtcttc gtggtcgaga
     2701 acgcggacgc ggtacgggcc gcgggccgca ccccggatgc cgaggtgctc tccgtcgagg
     2761 tcggggtctt cgacccgccg ggccccgacg gcgagttcag ccgcggcctc gggctgtgca
     2821 tcagccgagc cctggagcgg gcgggcgtca ccgcggccga catcacggcg gtggccaccg
     2881 ccgccaacgg gatgacgctg ctcgacgagg ccgaggagcg tgccatcggc gccatcgtcg
     2941 gcgctgacgt ggcacggctg cgggtcaagg acgccaccgg cgaggcgttc agcgcctccg
     3001 gcgccttcca gctcgccgcg ctgctcgccc ggcaccgggc ggagcccgcg cgggacggcg
     3061 agctgtcgct gatcaccacg cggtccgccg aaggcgcggc cggggcggcc gtcgtcaggg
     3121 ggtggagtcg tgccggtggc gatcacgggt agctccatgg tgagctgcca cggcgatctc
     3181 gacgccacgt tcgacgcgct ggtcgccggg cgcagcgggg cctccccgct gcgcgccggc
     3241 gacccggcca agctgaacgt cacccatggg tacggcatcg acgacgccac cgagcgcgcc
     3301 taccgcgaga cggtcgcggc ggccggcagc gcgagcggcg ccgcgggggg cgccgccgcg
     3361 gacgaggcgt acggcatcgg cgatgacgtg cggctctccg ggcgctggct ggcccaggcg
     3421 gtcgccggtg cgctcgccga ggccggcgtg gactcgcgga ccagcagggt cgcggtcatc
     3481 gtcggcaccg ggctgcgcga gctgcgcgcc gtcgagcagt ggcacggcga cgacgccgcg
     3541 ctgcggctgg cccagacgca cttcaacgag gccgtgcggt cggtcgcccc cggcgtgacc
     3601 gaggtgcaca cgctcgccaa cgcgtgcgcc gcctccggct acgccctcgc gctcgccgcc
     3661 gacctgctcg aactcggcga ggccgatgcg gtggtggccg ccggctgcga cacgttcacc
     3721 gagtcgatgc tcaccatgat cggccgcgtt ggcaccacca cggccgagac cgtacgaccc
     3781 ttcgacaccg accgggacgg ggtgctgctc ggtgagggcg ccgccgccgt cgtcctcgaa
     3841 ctgccgtcga gcaagccggc gttcggcctc atccggggcg tgggcatcgg ctgcgacgcg
     3901 ttccacgaga cggcgcccga cccgaacggc atcctcgcca cgatgcgcga ggcacaccag
     3961 cgcgccggca tcgaggccgg cgatgtggac ctggtcgtcg cgcacggcac gtcgaccgcg
     4021 ctgaacgatc cgaccgaggc caccgcgctg gccgaactct tcggcgacat cgcgccggcc
     4081 gacgcgcccg ccgtcaccgg catcaagggt gccatcgggc acacctcggg cggcgcggcc
     4141 ctgatgagcg tgctcgtcgc ctgccaggcc atgcgtaagg gcaccgtgcc ccccgtcacc
     4201 gggctgcgca ccgcgatccc ggaggccgag aagctggccc tggtgatcgg ggagccgctg
     4261 gccgcccggc cgcggatcgc gcaggtcaac gccttcggct tcggcggcgt caacgccgtc
     4321 accatcgtgg aggccgtcga tgcctgagtc ccagatcgcc caccgcacgg cggatcggcc
     4381 gcttgccatc gccggctggg ccgtgcacgt gcccggactg tccgcggccg acctgccggg
     4441 ctcgcccgat gaggcggcct gcgggcccga ggacgccaag gacgtgctgg gccgtaaggg
     4501 gctgctcggc aaggagccgt ccacgcggct ggcgctgtgc gccgtgcacc gcgcgctcgg
     4561 gctgcccgcg ggcaagctgg ccgagccgct gccgtacgcg ccacgcaccg ccgtcgtcgt
     4621 cgcctccaac ctcggcaacg tggagaccgt caccacggtc ctggacgaca tgcgctcgcg
     4681 cggcggcaac gtcgtcagcc cgctggacgc ccccaacgcg tccagcaacg tcatcgcctc
     4741 ctcgatcgcc atcaagtacg gcttcaacgg tcccaacctg gccgtgtgct ccggcgcgac
     4801 ggcagggctc gacgccgtgc gcctggcccg gctgctgctg ctcagcgggc gcgccgagcg
     4861 cgccgtcgtc gtcggcgtcg agcccgccga cccggtggcc cgcgcactgg ccgcgctgcg
     4921 ccccggcgac cccggcgagc tgatcgccgg cgccggctgc gtgctgctcg gcccgcccgg
     4981 cgcctggccc accgacaccg gcatcaccgt cggcccggtc gtccgccacg ccagcgaccc
     5041 ggggacggcc gaaggacagc cggctgtggg cgagctgtac ggggcggcgg gcgtggtccg
     5101 cctggccgcg gctgccgcgg tgttggccgg cggcgcgagc ggcgacgacg acgcggccgg
     5161 cctgaccgtc cactgcggcg acgcggacga cgcctggttg accgtggacg tgacccgcgc
     5221 cggggaccgg caggaagcgg gggcggcggc atgaccgtgc aggacggctg gacgctggtc
     5281 gcgaccgagg gacccgtgca ggtgtggcgg ggccccggaa gcggtccgcc gattgtcgcc
     5341 gcgcacggca tggaggacgg ctggaagagt tggcgtaccg tgctcggcgc gctgcccggc
     5401 tacaccccgt actcgctgca tctgccctgg tgtgccggca ccgattacgc gtggaccgct
     5461 gacggcagcc ccaaggagtg gctgcggcgc gccctggcgt tgctgccgga gcccccgcgg
     5521 gcgctgttcg gccactcctt cggtgcgaac gccatcctgg cccatctggc cgtcctgccc
     5581 caacaggacg gtctcgcggc ggagttggat gccgtggtgc tggtcgcccc gttctaccgg
     5641 cccgtcgggt tcccgctcag tgaccaactg cggttgcgct cggtggccgc gctgcgccgg
     5701 gtgctggtcg aggggctgcg ggtcaccctc ggtccgcggg ccgcccggat ggaccgcgag
     5761 gtgctggccc tgatggagtg caagctcctc gatcgggccg tgcccagcgc gtttcccgtc
     5821 ttctacgagg cgttcgagga ctccggccac ctcgacctgt cccgcgtcac ggtgcccacg
     5881 ctgatttacg tagggcccgg cgacgagggc ctgacgccga tgcgcgcgaa ggccctggcc
     5941 gacgccgtac ccggcgcgac gctgctcagc cgccgcggct acggccactt ctgccacatc
     6001 gaccgggccg aggagatgac cgcggaggtc gccgacttcc tccgcgaccc tcggtccgcc
     6061 gctgactcat ccgaaggagg aacaaccgtg actgaactgc tcgacggaca gccgaccagc
     6121 tatgtcggcc agccccgcta cgagggcgcc aacattcgca cctggatcgg gttcaagcac
     6181 ttcatgtacc tggtcgagga gggggtgttg cagtacttcc gcgaccgcgg cgtcggtgcc
     6241 cgcgacatct accaccgcta cggtctcggc ctggagatcg tcgactcctc cgtgcagctg
     6301 ccggtggccc ttgaggccga ggagcaggtg tacgccaccg tcgtctccgg caagccgaag
     6361 ccgggccagg gcgcgccgtt caacgtctcg ctgacggtgg agcgcgaggg cgagacggtg
     6421 accgtcctca agggcaaggt gcaggtcgcc ctggtcgccg tcaaggacgg ctcgggttcc
     6481 gagccggtgc cggccatcct ggagccgtac gtcgtgccgg acgtcgccgc gctgaccaac
     6541 tcggccaagg ccacgctgga gatccccgca ggcgccagcg tccaggacgt gctcgccccc
     6601 gagggctcgg gcgcctacct gtgggactgg cgcgcgccgt actactactg ccacttctcc
     6661 gaccggctcc agcactccgc gtacatccgg acgatggagg aggtcgtgga ccgcttcctg
     6721 gccgaccgcg gcctggccgt cggcacgctg ctcgacgagc gcggctggat tccggtggtc
     6781 tcccgggctc gcgtgcagat gctctcggac atctacatgg aggagacggt gcacaccgtc
     6841 ttcaaggtcg aggacatcct caaggacacc atgtacaccg cgcgcatgga ctgctacgtg
     6901 cgtcgcggcg acaccctgga gcgcgccgcc accggcacga tcatgcacgg gtacgccatc
     6961 agccgcggcg agaaggccgg cacggtcgcc gtcctggacg aggccaccca ggcgacgctc
     7021 ctcgggggtg ccgcatgagg aagccgccgc gcctgtactt ctcgctgcgc tcgccgttca
     7081 gttggatggc ggtgcgccag cttgaggagc gcattccgaa cgcgcaggac ctcatcgagt
     7141 acatcccgtt cttcgagccc gacgccacca gcagcaaggc gcttgaggag cagggtggcg
     7201 agttccacta cgtggccatg agcaaggcca agcacctgta catcctcaac gacaccaagc
     7261 gcctgtcgca gaagtacggc tacccgatga agtggccgat cgacaagggc gacgagtggt
     7321 gggagctgcc gcacctggcc tggatcaagg ccaaggagct cggcgtccac cgcgagtact
     7381 acaccgcggc gatggccgcc cgctgggagc gcggcgagga catctgcaac cgcgacacgc
     7441 tgcgccaggt gtgcctggac gccggactcg acgccgaggc cctggtgaac gcgcccgagg
     7501 aggcgcacat ccgcgaggcg ggcgtacagg ccctgatgcg cgtgtacgag gacgacgtgt
     7561 tcggcgtccc gtacttcaag gtcggccggc accgcttctg gggcctggac cggctggacg
     7621 acttcgtgac cacgctggaa gaggcgttgg ccaccgccgc gagcaaggcc gcgtgaagga
     7681 gagctgagcg atgaccgcag tagccactga gaccgagacc gccgactacc cgctgatcga
     7741 cgccgagtgg ggccccgacc cgctggccga catccccgct gacctgatcc agcggcacgg
     7801 ctccatggac cacgacaccg cgggcggctg cggctgacgc cgtagcgccc cgatcgcacg
     7861 gacgagagga cgagaacagt gaccgagacc gacaccgaaa cgcagcgccc catggcgatc
     7921 gtcacgggcg gctcgcgcgg catcggccgc gcctgcgccg tccagttggc gaccgacggc
     7981 tacgacgtcg cgttctgcta ccgcagcggc aacgacgccg cggccgagac cgagaagctc
     8041 atccgcgagc agggtgcgca ggtctaccac gcgccctgcg acgtggccga ctacgacgcg
     8101 gtgcaggcgt tcatcaagga cgccaaggcg gcgctcggcc cggtcagcgt tctcgtcaac
     8161 tcggccggca tcgtcaagga caacccgatg gtcctgatgc cgcacgagga ctggcaggcc
     8221 gtcatcgaca ccaacctgaa cggcacgttc aacttctgcc gctcggtcgt cttcgacttc
     8281 atgaagcgca aggagggcgt catcgtcaac atgtcctcca tctccggcgt ctacggccac
     8341 gccacccaga ccaactactc cgcctccaag gccggcatcc agggcatgag cgcctcgctg
     8401 gccaaggagg tcgccgggta cggcatccgg gtcaacgtgg tcgcgcccgg cttcatcgag
     8461 acggacatga ccgaggccct gccggagaag ctgcgcgccc aggccctcaa gtccatcccc
     8521 atgaagcgct acggcggcgc cgacgaggtc gcctacctgg tgtccttcct ggtctccgac
     8581 cgggccaagt acatcaccgg cgaggtcatc gaggtcgacg gcggagtctc gctgtgacga
     8641 ccacccagca ggcgggggcc cggccggccc gacggcggta cggccgcccc cgccgggccg
     8701 gcgttcacgc cggtcaccgg caagctgcgg gccacgccca tcgacccggt ggacgaggtc
     8761 gcggtggtct ccgagaccga ggtcatcgtc cgcaagaccg tccgcgacga cgacccgtac
     8821 ctcgaaggcc actacccccg agttcaccgt ctacccgggc gccttcatca tcgagtccgt
     8881 cttcgacgcg gtactgcacc tggtacgcgc tcaccgcggc gagcagacgt tcatcgagcc
     8941 ggccgagatt tcctcggtgc ggttcaccac cgccctgcgc cccggcgaca ccctccaggt
     9001 gcgctgcgtg tgccaggcag ttgatgacgc gaacggcgcg aacggtgcga gcactgtgcg
     9061 cgtcgtcgcg cactgcacca acggggaggc caaggcggca ctcgtcaaga tggcgttccg
     9121 cgtgctgccc accgaggaac caaccagatc gggcccagcc tgaccggccg tcgccggccc
     9181 atcggccgcc aggccatcta acgtacgggg gacttcatga tcgactacgc cgagctgcgc
     9241 gaactgatac cgcacgccca cccgatcctg ctcgtggaca aggtgctcga catcgcaccc
     9301 ccggaccgga tcaccaccgc gaagaccgtg accggcagcg agccgtgcta cgcgggcatc
     9361 gcccccgggg cacccacccg cgccttcgcc tacccgcccg cgctcctcat ggagtcctgg
     9421 ggccagggcg gcgcgcttct gtggatgcag cacgtgcagt cccaggcacg cgagcgcaac
     9481 ggcgggctga tcctggccgc cgcccgcggc atggagttcc gccgccccgt ctacccgggc
     9541 gacacgctgc gccacgaggt gcgcatcgac cagttcgtcg gcgacaacgt gatcatgagc
     9601 ggcgagagct acgtggacgg cgagttggcc tccaaggtgg actacgccat cgccgtcatg
     9661 cgcccatcca acgaactgac ctgggcctcc tgatgaccac cgacgtcgtc atcaccggtc
     9721 tcggggtcgt atcgccgctc ggcaacgacc caggggagta ctgggagcgg ttgctgcgcg
     9781 gcgaggtgcc ggtgcgcccg ctcgtggcgc ccggcaccgc cgtcgacggc atccacacct
     9841 acccggtcac cgacaccccg cagcccgccc cgcaccccgg cgaccagccg ggccgggcca
     9901 gcggcttcgc gctggccgcc gccggcgacg cgctgcgcga cgccggtctc gcggacgccg
     9961 ggcccgcggt gctcgacggc gttggcatgg tcgtgggtac cggcaacggc gacagcgacc
    10021 tgcgcgaggc cgagcgcgac ggccgccgcg agttgagcgg cttgcagtgg tacccgtacg
    10081 acaccgcggg cctgctcgcc gagcggctcg cgctgcacgg cccgagcctg accgtctcca
    10141 ccgcctgcgc ggccggcgcc tacgcggtgg ccatgggcgc cgagatgatc cgcaccggcg
    10201 aggccgatgt ggtcctggtc ggcggcaccg aggccgtctc gcggcccgcc gtcggcgcgt
    10261 tcctgcgtct gggcgccgcc gagcccggcc cctgccgccc cttcgacacc gaccgggccg
    10321 gcaccgtgta cggggagggc gccgccttcc tcgtcctgga gtcggccgct cacgcgcgca
    10381 gccgtggcgc cagcccgtac gcccgggtgc tggactccgg gtggagctgc gacgccttcc
    10441 acgagaccgc gcccgacccg ctgggctccc aggcgctgcg cgcggtgcgt gaggcgctcc
    10501 agcgctccgg gctcgaccgg gacgacatcg gcgcggtgct ctgccacggc accggcacgc
    10561 cggccaacga cgcggtggag agccgcacca cggccgccct gctcggggcg cgcacgcccg
    10621 aggtcccggt gacggccatc aaggcgtcac tcggccacag cggcggcgcg gccggcgcgt
    10681 tctcctgtct gaccgcggcc ctggtgctgc gggacggcgc cgtgccgccc gtgggcaccc
    10741 tgcgcgaact cgaccccgcc tgcgagctgc gggtggtccg cgaggcgccg caggccagcg
    10801 ccggcagcgc ggtgctcgtc aacgcgtacg cgttcggcgg caacaacatc tccgtcgccc
    10861 tcgcggccct ggaccccgcc gcggcggccg aggccgaccc gggcgccgcc accgagaccc
    10921 acgggtgggc cgccaggcgc ccccgccccg tgcccctgcg ggagggagca gcgtgaacgt
    10981 caccactacg acaccggtcg ccatcaccgg cgtcggcgtc atcagccgcc ccgccatcgg
    11041 ggcacaggag ttggcccggg ccgccgacct ctggcactcc gagcccagcg accccaccga
    11101 ccccaccaac aacgaacgtc cctgggctat agccgagttg gacaacttcg cgcccgccga
    11161 gttcctcggc aagcgcggct ggcggttcct gcccgaggcc acccgggtgg cgctcgccgc
    11221 cgtccaactc gcgctggcac acgccaacga ggccgccgac gatgccacgg agcacgcgcc
    11281 cgagcgggtc ggcgtggcgc tcggcaccaa cttcgccgtc gacgccgtcg tggaccgcat
    11341 cgaccgggcc ctgctggccg agggcatcgc cggcatcagc cccgtcgagt gccccaactt
    11401 ctccgtcaac gtccccgccg gccggctcgg catcgcgcac ggcctgcgcg ccttcaacat
    11461 cacgctggtc aacctgctca ccgcggggct cgaatcggcg ctggtcggcg cccgcgcgat
    11521 ggccgacgac cgggccgacg ccgtactggt cggcgccgtc gagggccgcc caccggccgc
    11581 cgcccgcacc gtcaccgggc ccggcgtgga cgcggccggc gcctgcctgc tgcacctgga
    11641 gcgccccgag cgcgcggccg agcgtggcgc cgccgtacac gcccagctca ccgggggctc
    11701 gcggcgcacc gtgcccggca accccgccgc cgcccagcgc gtgctggccg cggcgctgga
    11761 cgccctgggc gccccgcccg gcgtgctgca cctgagcctg ccggccgagg gcggcgagca
    11821 cgtcgcgcag gcggccgagg actgggcgaa ggcccgcggc gcgggcaccg gcctgaccgt
    11881 gaccaccggc gccccgcaag gctcggcaac cccggtactc ggcctggccc aacacctggt
    11941 gcgcggcgtg cacgagagcg ccgtggtcgg cgcgctcggc ccgcgcggca acctcactct
    12001 gctgcgcatc gagccgcccc ggagccgggc atgagccccg agtccggacc cgccccggtg
    12061 aaggcgtcgc tgctgtacgg cgaggaactg gccgtccacc ggttcgccga gctgcccgcc
    12121 gccgccctcg tacacggcct ggaggacgac tggagcagct acaccaagct gagccagctc
    12181 ctgtccgggc gctttcgcag cttcccgctc gatatgccct ggcgctcggg cggcacctac
    12241 cgctggcggg ccagggccac cagcggccag tggatcgagg gcggcctgca gatgatgccc
    12301 gagccggtct cggtgctcat cgcgcactcc atgggcgcca actccgtgct ccagtggctg
    12361 gcctcgggcg ccaaccccaa gctggacgcg ctgatcctgc tctccccctt ctactggtcg
    12421 cccacccaac ccgtggactg ggcgatcttc gacggcttcc ggcagcagtt cgcggccgtc
    12481 atgaccgccg ggctgcaaac ccggctgggc ccgcgggccc acacgatgga ccccgacatc
    12541 ttcaacacca tggtgcgcaa gatgttggag aagatgggcc cccaggcgtt cctggccctc
    12601 ttcgaccaat acagcgcggc gtcctcgctc gcgctgtccc acgtatcggt tcccacgctg
    12661 gtgatcggca gccccaacga cccggggatg ctgggcgatc gtgccgatgc gctccaagcg
    12721 gacatgccca gcgccgaact gtgcatggac ccccgcttca gccacttctg ccacgtcgaa
    12781 caggcgcagg aagtggccga tctgatcatc gcgttcgtgg accgccagcg ggcgggctaa
    12841 caccgagacg aagggcacga ggacacctca tgtcgggaaa caccttgcac ctacgggcgt
    12901 tgccaccacg caacaagccc ggcctgaccc tgctggccgc actgctcggc ctgttcatcg
    12961 cgctgctcga cgtcaccgtc gtcaccgtgg ccatgccgac catcggcgag gacctggacg
    13021 ccaccttcga cgacctggag tgggtggcca acgcgtacat gctggccctc gccgtcctca
    13081 tcgtcaccgc gggccggctc ggtgacctgt acgggcagcg ggtcatctac gtcatcggcg
    13141 tggtcatctt cctcgccggc tcggtgctgt gcgccgccgc gggcgagatc accctgctcg
    13201 gcgccgagca catcaccacc ctgcacgtgg gtcgcgtggt gcagggtgtg ggtggcgccg
    13261 tcgtcatgcc gctgacgctg gccatcgtct actcctcctt cgagggcaag gcgcgcgcca
    13321 agggcatcat gatgtggggc gccgtcggcg gtctggccac cgcactcggc ccgctgatcg
    13381 gcgggctcct ggtggaccac gccggctggg agtggatctt cctcatcaac gtgccgatcg
    13441 gcgcggtcgt catcttcgcc gccctcgccg gcatgggcgc cgaccagcgc cgcgccacca
    13501 gcggcaactc catcgacctg cccgggctgc tcaccctcag cgcctcgctg ctctgcatca
    13561 acctggccct gatcaacggc aactcctggg gctggaccag cgccaaggtc ctcggcctgc
    13621 tcgccggtgg catcctcctg ctggccggct tcctggccgt ggaggcccgc tcgaaggccc
    13681 ccatcatgga cctcggctgg ttccgcaggc cgtccttcgg cggcagcatc gccacctcgt
    13741 tcctgctcgg cgccggcatg ttctcggtga tcttctacct gtcgatctac ctccagaccg
    13801 gcctcgacct cagcgcccag gagaccggcg tccggctgct gcccatgacg ctgatgctga
    13861 tgatcggcgc acccgtcggc ggccggatcg tcgccaaggc cggcgtccgc aaggccctca
    13921 tcttcgcgat gacgctgatg gccgtcggca tcgcgctcta caccctggcc gaccccaagg
    13981 gcgactccgg ctcctggacc ctgctgctgc ccggcatgct gctgaccggc ctggccatgg
    14041 gcgtcgcgat gcccgtcgcc tccgaactga ccatctcctc cgccccgcag gaccaggtgg
    14101 gcgtggccgc cagcgccggc accatgatcc gccaggtcgg caacgcggtc ggcatcgcca
    14161 tcatgggcgc gctgatgagc aaccgcaccg acgcggccac cgaggagatg atcgacctcc
    14221 agcgcaaggg cgaggcgacc gccgaggccg ccgccgcgct ccagcagaag gccgtcaccg
    14281 agggcatgga gaacggtgcc tggtacgccg cggccatcac cctggtcggc gcggtcctgg
    14341 tggtcctctt cgtacgcgat acccagtccc cgacagggac ctccgctgcg ccgcccgccc
    14401 cgccgcggcc ccgcccggac gacacgatgc gcctcagcaa gctgccgagc gcgtgaggag
    14461 aacgcgatga cgcacaccga cacccagcac cccgcggccc cggcttcccc cgcggccccg
    14521 gcagccgcga cggccccggc cgcctccggc gccagcgaca ccgagggtca gcgcggcaag
    14581 accgcgttcc tcttccccgg ccagggctcc cagaaggtcg gcatgggcct cgacgtcatc
    14641 gcggcccgcc ccgacctggt ggagacctat taccagcagg ccgatgacat cctcggcatc
    14701 ccgctgtcca agctgtgctg ggagggcccc gaggacgcgc tgcgcgacac cgccatcacc
    14761 cagcccgcgg tcttcctcac cagcctggtc accctcgacc tgctcggcga ccggggcgta
    14821 caccccgatg tcgtggccgg acacagcctc ggcgagtaca ccgccctggt cgccgccggc
    14881 gtactcgact ggcgcgacgc gctgcgcctg gtgcgccgcc gcggccagtt gatggccggc
    14941 gtcaacgagc gggtgccagg cgccatggcc gccgtgctcg gcctggacct ggccaccgtc
    15001 gaggaaatct gcgccgaggt cgcggccgag accggccagg tcgccgaggt cgccaacgac
    15061 aacgagccag gacagtccgt cgtctccggc gaggccggcg ccatcgagaa ggtccgcgag
    15121 gccgcgcagc gcgccggagc cgtcaaggcc atcgccctac cggtcggcgc gcccttccac
    15181 tgcgccctga tgcgcggcat cgaggaggag ttcgccgccg aactggatca ggtcaccttc
    15241 cgtgagccca gcaccccggt cgtctccggc gtcaccgccg actacgccac cagcgcccgc
    15301 ggcatcaccg acgcgctgcg ccggcaactc gccggccggg tgcggtggac cggctccgtg
    15361 caactgatgg ccgcgtccgg cgtgacccac ttcgtcgagg tcggccccgg caaggtgctc
    15421 agcggcctgt gccggcgcat cgtgcccgag ctgacgtcgt acaccacgaa cgacgagcgc
    15481 cgactggcca agaccctcga cgccctcgca cccacagccg ccgtagcggc ctgacaccag
    15541 caaagcccag ggggacgcgc accatgagca tcaccgacga tcggcggatc accaccgacg
    15601 acctgcccga ggacccgagc accggcggac tgcccgaaca gctcctgaaa ctccgcgagt
    15661 tgaaggaggg catttacgcg ggcgacccgg ccgccaccga gcgccagcac gccaagaaca
    15721 agctcaccgc ccgcgagcgc atcgacctgc tcctcgacga gggctcgttc cacgagatcg
    15781 agacgctgcg ccgacaccgc gccagcggct tcgggctcga acacaagaag ccgcacaccg
    15841 acggcgtcat caccggctgg ggcaccgtgc acggccgcac cgtcttcgtc tacgcccacg
    15901 acttccggat cttcggcggc gcactcggcg aggcccacgc acagaagatc cacaagctga
    15961 tggacctggc cgagtccgcc ggtgccccgc tggtctccct caacgacggc gccggcgccc
    16021 gcatccagga gggcgtcacc gcgctcgccg gctacggcgg catcttccag cgcaacaccc
    16081 gctgctccgg cgtcatcccg cagatttcgg tcatgctcgg cccgtgcgcc ggtggcgcgg
    16141 cctactcgcc ggccctgacc gacttcgtct tcatggtccg cgagagctcg cagatgttca
    16201 tcaccgggcc cgacgtcgta cgcgccgtca ccggcgagga gatcagccag aacggcctcg
    16261 gcggcgccga cgtgcacgcc tccgtatcgg gcgtggcggc cttcgcctac gacgacgagg
    16321 aaagctgcct cgaagaggtc cgctacctgc tgtcgatgct gccgcagaac aaccgcgaga
    16381 ccgcgcccgt cgaggagacc gaggacccgg ccgaccgcag cacggacgcg ctgctcgacc
    16441 tggtgcccgg cgaccccaac cgctcgtacg acatgcgcca ggtcatcgag gagatcgtgg
    16501 acgaccacga cttcttcgag gtccaaccca cctgggccac caacatcatc tgcgccctgg
    16561 cccggctcga cggccacgtc gtgggcatcg tcgccaacca gcccgcctcg ctcgccggcg
    16621 tgctggacat ccacgccagc gagaaggccg cgcgcttcgt gcagacctgc gacgccttca
    16681 acatcccgct ggtcagcctc gtggacgtgc ccggcttcct gcccggcgtg gaccaggaac
    16741 acggcggcat catccgacac ggcgccaagc tgctctacgc ctactgcaac gccaccgtcc
    16801 cccgcgtcca ggtcatcctg cgcaaggcgt acggcggcgc gtacatcgtc atggactccc
    16861 gctccatcgg cgtggacgtc tcgctggcct ggcccagcaa cgagatcgcc gtgatgggcg
    16921 ccgagggcgc cgccaacgtc atcttccgcc gcgagatcgc cgcggccgac gacccggacg
    16981 cggtgcgcca gcagaagatc aaggagtatc agagcgagct catgcacccg tactacgcgg
    17041 ccgaacgcgg cctggtggac gacgtcatcg acccgcgcga gacccgctcc gcgctgatca
    17101 gctcgctggc catgctccgc accaagcacg ccaacctgcc ctcccgcaag cacggaaacc
    17161 cgccggtgtg atgggcgaga cacggcacgg cggcgcgccc agcgccgtcc acgagcagcc
    17221 caccacccac gccgccgcca acctggccgc cgacgcccac ctacgggtcg tacgcggcgc
    17281 gccgggcgcc gaggaagtcg ccgcgctcgc cgcggtgttc gccgccctgg cccagggcgc
    17341 gcgccgcggc ccggcccgcg gcccgagccg cccccgggtg agctgggacc acccgggcca
    17401 cggccgcgcc agcgccctcg gctaccgggc gcccgggtcg tggaccgcat gagcggcgcc
    17461 ttacccaagg cgcccgggac gcgagccgcg gcggcgggtg gccagcccgc cgcggccggc
    17521 acgcctgacg gcactcggcc gttgacgaag gtgacgacgc tggcggcgcc gtcagcggag
    17581 ccgacgcacc cggcctgggt gacgcggtcg gtggggaaag gaaaacggag acccatgcgc
    17641 aaggtgctca tcgccaaccg tggcgaaatc gctgtccgtg ttgcccgtgc ttgtcgggat
    17701 gccgggatcg ggagtgtggc ggtgtacgcg gacccggatc gggacgcgtt gcatgtgcgg
    17761 gttgccgatg aggcgtacgc gttgggtggt gatactcccg ccacgagtta tttggatatg
    17821 ggcaaggtgt tggccgcggc ggcggagtcg ggtgcggatg cggtccaccc tggttatggg
    17881 ttcttgtcgg agaacgcgga cttcgctcag gcggtgttgg atgcggggtt gacgtggatt
    17941 ggtccgccgc cgcaggccat ccgtgatctg ggggacaagg tcgcggcgcg tcatatcgct
    18001 cagcgtgcgg gggctccgtt ggtggcgggg acggcggatc cggtctcggg tgcggatgag
    18061 gtggtggctt tcgcgcgtga gcatgggttg ccgatcgcga tcaaggcggc ttttggtggt
    18121 ggtgggcgtg ggttgaaggt ggctcgttcg ctggatgagg tggccgagtt gtatgactcg
    18181 gcggtgcgtg aggcggtggc cgcctttggg cggggtgagt gtttcgtgga gcggtatctg
    18241 gatcgtccgc ggcatgtgga gacccagtgc ctggccgacc agcacggcaa tgtcgtggtg
    18301 gtctccacgc gggactgctc cctccagcgt cggcatcaga agctggtgga ggaggccccg
    18361 gcgccgttct tgtccgaggc gcagaacgcg gagctgtatc gggcttcgaa ggcgattttg
    18421 cgtgaggccg ggtatgtggg ggctggtacg tgtgagttcc tggtgggtca ggacggcacg
    18481 atctccttcc tggaggtcaa cacccgcttg caggtggagc atccggtcac cgaggaggtc
    18541 actggtcttg acttggtgcg ggagatgttc cggatcgccg atggcgagga actgggctac
    18601 gaggacccgc cggtgcgtgg gcattccttt gagtttcgtg tcaatggtga ggacccgggg
    18661 cgtgggttct tgccggcgcc tggtgtggtg acgcggttcg cggggccctc gggtccgggt
    18721 gtgcggttgg atgcgggggt ggagtcgggt tcggtgattg gtccggcgtg ggattcgttg
    18781 ttggcgaagt tgatcgtgac gggtgcgtcg cggcggcagg cgttggagcg ggccgcgcgg
    18841 gcgttgggtg agttcgaggt cgaggggatg gcgaccgcgc tgcccttcca tcgtgctgtg
    18901 gttgccgatc cggcgttcgc gccggagcgc tcggggtcgg tggatgcgtt tagggtgcat
    18961 acgcggtgga ttgagacgga gttcgtcaac gacattcccc cgttcgtccc tggtgaggtc
    19021 gcgggtgagg acggcgaggg cgagggcgct ggccgtgaga ccgtggtggt cgaggtcggt
    19081 ggcaagcgcc tggaggtctc cctccccgcg tcactgggct tcgcccccac aaccggcaac
    19141 ggcggcggag cggcgggcgg cgcgagcaag accaagcgta agaagaccaa ggccgcgggc
    19201 agcgcggcca ccggcgatgc gctggcctcc ccgatgcagg gcaccatcgt caaggccgcg
    19261 gtggaggagg gccagcgggt ggaggagggc gacctcatcg tggtcctgga ggcgatgaag
    19321 atggagcagc cgctcaatgc ccaccgcgcc ggcatcgtgc acggcctgga ggccgctgtc
    19381 ggaggctccg tatcggccgg cgccgtcatc tgtcagatca aggacgagca actcgccacc
    19441 gtgtgagcga gcgcgcggcg cccgcccggg gtcgtggggc gggcgccggg ggagcggggc
    19501 gagcggtgtg cgcgtgcgtg gagtgcgcgg gcgcgcgtgc aagccttggg ccgagaccga
    19561 agcaagccag caagccaagc aggcacgcag aaggagagcg acgtggcgcg aggacctgtc
    19621 gtccgcaagt ccgccgaggc cgtgagcccg agcggggaga agagcctggg cggtgtcgat
    19681 cacgtggaca cggtggcggt ggacgtcgcc cccggcacca ccccggccga gttcgccaag
    19741 gccatgatga gttcgccacc caagtgggtc ctcgtcctga tgaccgtacg cgacaagatc
    19801 gtcaagccgt tcggcctgcg cggcggtccc gtgcaggagc ccggtgaggt cgctcccggc
    19861 gcgaagctcg gcccgatgcg ggtcatcgac gtctccgccg acgaggtggt ggcgggcaag
    19921 gacgacaagc acctgagcta ccgggtgatc ttcgtcgtac gcgacggggc gcacggcacc
    19981 gagggcgcgt gcagcaccgt cgtccgctac aaccggccgg cgggcaagcg atacttcgcc
    20041 gcaatccgcc ccttccacaa cacgatcatg gccaacttcg ccaagcgcgg cggcgccacc
    20101 ctgggctgag cccggtctcc cagagcccag ccggccgccg ctcctccccc ggggtcggcg
    20161 gccggctgca tcgacccgtc agcccg
//
