BGC0002547 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002547 (Streptomyces youssoufiensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	arylpolyene	1	20,186	High	youssoufene A1/youssoufene B1/youssoufene B2/youssoufene B3/youssoufene B4	PKS

BGC0002547 - Region 1 - arylpolyene

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Location: 1 - 20,186 nt. (total: 20,186 nt) Show pHMM detection rules used

Region on contig edge.

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 20,187
Label		BGC0002547

Tailoring functions

Oxidoreductases: dehydrogenase

ysfH: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase carboxylase transferase

ysfN: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

ysfO: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

ysfP: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase

ysfB: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ysfC: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ysfD: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ysfJ: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002547.2	1.00	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces youssoufiensis
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002510.2	0.53	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0001987.2	0.51	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0000866.5	0.50	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0002378.3	0.48	NRPS	coprisamide C, coprisamide D	Streptomyces sp.
BGC0000234.5	0.47	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197.5	0.47	PKS	frankiamicin	Frankia sp. EAN1pec

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002547.2	1.00	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces youssoufiensis
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002510.2	0.53	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0001987.2	0.51	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0000866.5	0.50	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0002378.3	0.48	NRPS	coprisamide C, coprisamide D	Streptomyces sp.
BGC0000234.5	0.47	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197.5	0.47	PKS	frankiamicin	Frankia sp. EAN1pec

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

NRPS/PKS substrate predictions

ysfN: mal

PKS_AT (41..331): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 81.3
inactive: 42.4
Methoxymalonyl-CoA: 29.2
Methylmalonyl-CoA: 26.1
Acetyl-CoA: 15.2
fatty_acid: 13.6
Propionyl-CoA: 12.1
Isobutyryl-CoA: 11.8
2-Methylbutyryl-CoA: 8.5
Ethylmalonyl-CoA: 3.0
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor