BGC0002555 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002555 (Acremonium sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	64,157	High	emerimicin V/emerimicin VI/emerimicin VII/emerimicin VIII/emerimicin IX/emerimicin X	NRPS:Type I+PKS

BGC0002555 - Region 1 - NRPS

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Location: 1 - 64,157 nt. (total: 64,157 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

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transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 64,158
Label		BGC0002555

Tailoring functions

Transferases: acylase

emeB: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002555.3	0.98	NRPS, PKS	emerimicin V, emerimicin VI, emerimicin VII, emerimicin VIII, emerimicin IX, emerimicin X	Acremonium sp.
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.70	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.70	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001240.4	0.68	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001844.4	0.52	NRPS	holrhizin A, holrhizin B, holrhizin C, holrhizin D	Paraburkholderia rhizoxinica HKI 454
BGC0001371.4	0.52	NRPS	echinocandin B	Aspergillus nidulans NRRL 8112
BGC0002611.2	0.52	NRPS	mulundocandin	Aspergillus mulundensis
BGC0002543.3	0.50	NRPS	acrophiarin	Phialomyces arenicola
BGC0001035.5	0.48	NRPS, PKS	pneumocandin B0, pneumocandin A0	Glarea lozoyensis ATCC 20868

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002555.3	0.98	NRPS, PKS	emerimicin V, emerimicin VI, emerimicin VII, emerimicin VIII, emerimicin IX, emerimicin X	Acremonium sp.
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.70	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.70	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001240.4	0.68	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001844.4	0.52	NRPS	holrhizin A, holrhizin B, holrhizin C, holrhizin D	Paraburkholderia rhizoxinica HKI 454
BGC0001371.4	0.52	NRPS	echinocandin B	Aspergillus nidulans NRRL 8112
BGC0002611.2	0.52	NRPS	mulundocandin	Aspergillus mulundensis
BGC0002543.3	0.50	NRPS	acrophiarin	Phialomyces arenicola
BGC0001035.5	0.48	NRPS, PKS	pneumocandin B0, pneumocandin A0	Glarea lozoyensis ATCC 20868

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 64157:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Abu - X - Abu - Ival - X - Leu - X - X - X - Ala - X - X - Ival - Ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

emeB: mal - X - Abu - X - Abu - Ival - X - Leu - X - X - X - Ala - X - X - Ival - Ala

Search NORINE for peptide: strict or relaxed

PKS_AT (949..1259): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 69.2
Methylmalonyl-CoA: 69.1
Methoxymalonyl-CoA: 60.0
Isobutyryl-CoA: 44.0
Ethylmalonyl-CoA: 43.0
Propionyl-CoA: 33.4
Benzoyl-CoA: 32.0
3-Methylbutyryl-CoA: 27.6
trans-1,2-CPDA: 24.5
2-Methylbutyryl-CoA: 13.7
inactive: 10.2
CHC-CoA: 9.7
Acetyl-CoA: 7.7
fatty_acid: 0.0

AMP-binding (1906..2302): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A