BGC0002556 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002556 (Streptomyces sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	42,471	High	cervinomycin B3/cervinomycin C1/cervinomycin C2/cervinomycin C3/cervinomycin C4	other:other

BGC0002556 - Region 1 - T2PKS

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Location: 1 - 42,471 nt. (total: 42,471 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 42,472
Label		BGC0002556

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

cer1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

cer20: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

cer31: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

cer5: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

cer8: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase methyltransferase

cer10: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

cer15: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

cer2: aminotransferase

smcogs: SMCOG1019: aminotransferase

cer3: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

cer33: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: hydrolase

cer4: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: cyclase

cer22: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

cer25: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Ligases: synthase

cer23: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

cer24: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002556.2	1.00	other (other)	cervinomycin B3, cervinomycin C1, cervinomycin C2, cervinomycin C3, cervinomycin C4	Streptomyces sp.
BGC0000231.5	0.62	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.58	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000221.5	0.54	PKS	erdacin	uncultured soil bacterium V167
BGC0000217.5	0.53	PKS	daunorubicin	Streptomyces sp.
BGC0002000.4	0.53	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000841.5	0.53	other (non-nrp beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate, clavulanic acid	Streptomyces clavuligerus ATCC 27064
BGC0000272.3	0.52	PKS	spore pigment	Streptomyces collinus
BGC0001197.5	0.51	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001928.2	0.50	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002556.2	1.00	other (other)	cervinomycin B3, cervinomycin C1, cervinomycin C2, cervinomycin C3, cervinomycin C4	Streptomyces sp.
BGC0000231.5	0.62	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.58	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000221.5	0.54	PKS	erdacin	uncultured soil bacterium V167
BGC0000217.5	0.53	PKS	daunorubicin	Streptomyces sp.
BGC0002000.4	0.53	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000841.5	0.53	other (non-nrp beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate, clavulanic acid	Streptomyces clavuligerus ATCC 27064
BGC0000272.3	0.52	PKS	spore pigment	Streptomyces collinus
BGC0001197.5	0.51	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001928.2	0.50	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 42471
Starter unit(s):: malonamyl-CoA (Score: 548.0; E-value: 0)
Malonyl elongations:: 11|12 (Score: 630.4; E-value: 2.3e-192)
Product class(es):: pentangular polyphenol
Product molecular weight(s):: malonamyl-CoA_11: 565 Da
malonamyl-CoA_12: 607 Da

cer1: OXY (Score: 271.7; E-value: 3e-83)
cer10: MET C11O (Score: 472.0; E-value: 2.1e-144)
cer15: MET (Score: 216.8; E-value: 9.8e-67)
cer20: KR C19 (Score: 398.4; E-value: 2.7e-122)
cer22: CYC C9-C14 (Score: 223.8; E-value: 1.8e-69)
cer23: CLF 11|12 (Score: 630.4; E-value: 2.3e-192)
cer24: KS (Score: 753.8; E-value: 1e-229)
cer25: CYC C4-C21/C2-C23|C2-C19 (Score: 167.0; E-value: 2.3e-52)
cer28: CYC C5-C18 (Score: 206.8; E-value: 2.2e-64)
cer3: MET (Score: 207.4; E-value: 7.3e-64)
cer4: AMID (Score: 760.7; E-value: 2.1e-231); AMID ELQ83270.1_Oxytetracycline_malonamyl-CoA (Score: 548.0; E-value: 0.0)
cer5: OXY (Score: 181.5; E-value: 6.9e-56)
cer8: KR C11 (Score: 312.0; E-value: 6.1e-96)