LOCUS       BGC0002557             14827 bp    DNA     linear   PLN 24-JUL-2019
DEFINITION  Penicillium griseofulvum strain NRRL 35584 penifulvin biosynthetic
            gene cluster, complete sequence.
ACCESSION   BGC0002557
VERSION     BGC0002557
KEYWORDS    .
SOURCE      Penicillium griseofulvum
  ORGANISM  Penicillium griseofulvum
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Penicillium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:59:39
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..14827
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002557"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..14827
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..11770
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[0:1770]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..1770
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..11770
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     gene            complement(<1..>1770)
                     /gene="peniA"
     mRNA            complement(join(<1..85,160..377,459..492,568..657,742..898,
                     954..966,1029..1198,1262..1280,1356..1485,1568..>1770))
                     /gene="peniA"
                     /product="PeniA"
     CDS             complement(join(1..85,160..377,459..492,568..657,742..898,
                     954..966,1029..1198,1262..1280,1356..1485,1568..1770))
                     /codon_start=1
                     /gene="peniA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Terpene_synth_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Terpene synthase/cyclase metal-binding domain
                     protein (Score: 223.2; E-value: 9e-68)"
                     /gene_kind="biosynthetic"
                     /product="PeniA"
                     /protein_id="QDO73502.1"
                     /sec_met_domain="Terpene_synth_C (E-value: 6.6e-22,
                     bitscore: 66.8, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVIQPTTQIFADNEKTVSQVAEEISSNELRETTVYLPDLFVSFC
                     SRAPKTNPYYAEVKAESDAWFAKLYSLSTEKELSRLTKADFALFAAWWTADAGKSEFRT
                     ICDWCNWVFYFDDQFDEGHLCEDEAKAQREADILTQIMTVGLRDDEYPDDLPRARALRY
                     AFRSVWERISQRASAGVQRRFREAMQEFCKGLVGQVGVRADIDTRELDPYLAFRRQSIG
                     VVPCIVFAEYYHDLRLPDEFFEHPSVKTIMDLAAEITVLHNDVLSYHKEYEMGAIHNIV
                     IILRERGMTQQEAYNETDKLIQKRLREWHLAVNQLPFYGEALDLQVQKFVQACQEVAVG
                     NLHWSFATERYFGNQNNLIRKTRQVELIDLKA"
     gene            complement(<3160..>4755)
                     /gene="peniB"
     mRNA            complement(<3160..>4755)
                     /gene="peniB"
                     /product="PeniB"
     CDS             complement(3160..4755)
                     /codon_start=1
                     /gene="peniB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 173.7; E-value: 1.1e-52)"
                     /gene_kind="biosynthetic-additional"
                     /product="PeniB"
                     /protein_id="QDO73503.1"
                     /sec_met_domain="p450 (E-value: 1.3e-72, bitscore: 233.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTVQSLINITLPQPEIEAPAKLEYDRTRILSIAAVVFLGYLLLR
                     PLFDKRLPLPPAPTRLPLLGNLHQFPASNLWGTYKKWHNQYGPIMGLKYGQRTVISLGS
                     HEVAKDLLEKRSNIYSSRPNFVVAKAFSNDANSALIAYDERWKTHHSLLSTFMNARMAA
                     KYQFLQNIESKQALHDLMSVQGTEWMQVFHRYTISVTFTLAYGERIPELYDERILFIDE
                     LTETISSNVEKPKNLIADCFPTISILPSALMRWKKQGKVYHDSAMKFFLDNHAKALQKP
                     GWNWVKESQTSEDANKLDREEVIYLIGVLIEAGGSTMKTFEFFVMASILFPEKVRLVQE
                     EVDRVVGADRLPTWDDSPNLPYLHAFIREVQRWRPIFPFGVPHSNLKEDVYNGFRIPKD
                     SVVLANHWAMDSDHKVFENADDFVPERWLEDSKLPFLAFGYGKRVCPGQHIAKRSLFII
                     ISRTLWAYNITHAYEKGKKVEIDPHAIVQNILAGPVPFKGTFTPRDADRYRILEEEFSN
                     IGQDEANIWDVCKP"
     gene            <6296..>8208
                     /gene="peniC"
     mRNA            join(<6296..6638,6707..>8208)
                     /gene="peniC"
                     /product="PeniC"
     CDS             join(6296..6638,6707..8208)
                     /codon_start=1
                     /gene="peniC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092:hypothetical
                     protein (Score: 369.8; E-value: 4.2e-112)"
                     /gene_kind="biosynthetic-additional"
                     /product="PeniC"
                     /protein_id="QDO73504.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.3e-12, bitscore:
                     35.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSISPLPLTPDASCCPREVILEKYQQERKKRQLNCVPDNEATEL
                     HHKYAPVQGVDQPSYTRSPIITDSKVVIIGGGLAGLVTAVKLKTQGINDFVILEKGAEC
                     GGTWHWNQYPGAACDIESLIYLPLLEETGYVPQSRYSSGAEIRAHVARIILKWNLGEHI
                     CPLTQVTSTKWDESKLRWEVQTDHSDSLTCQFLVLATGLFHEPNLPRIPGSERFKGDQF
                     HSGRWDYAVTGGDPAGSVPMDKLATKTVGVIGTGASGVQIVPRLAQDAKKLYVFQRTPS
                     SITARDNYTMTPLMTEPVIQKPGWQRARMVQFCEMLEAEEHEMSDKDGTVAEGFDALSL
                     RKVLNGMRKDDVAPAQMGELYARADISLMESIRKHVSNTVDDHETAEKLKPWYPFLCKR
                     PVFQNDYLSSFNRSTVELVDTNGQGVSCLTEKGVVANGKEHEVDLLIYATGFDYEIGTP
                     FYQRTRIHVFGSHGQTLDDAWADQGPSTLFGIHIRDFPNLLYIGPCQAGVTFNFTHTIY
                     EAADHISHVIGDCLKDGASFQAIQPSIEAQSDWVKQTEEGSEMRLQYAQSCPPGYFNGH
                     GRPEKIPARWGYYPKGIKAWANAMRECRAEGMKGLERW"
     gene            complement(<8595..>9559)
                     /gene="peniD"
     mRNA            complement(join(<8595..8768,8825..>9559))
                     /gene="peniD"
                     /product="PeniD"
     CDS             complement(join(8595..8768,8825..9559))
                     /codon_start=1
                     /gene="peniD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /product="PeniD"
                     /protein_id="QDO73505.1"
                     /sec_met_domain="PhyH (E-value: 1.2e-19, bitscore: 60.1,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTAQPEFGLHSVDATAPVEEITKVMKHHGGVIVRGLVSEEVLQ
                     QVGREIKPFFKRGNHEGPFCERTRTVCSIPRKSRTFVEKIFGNPVYTAVCDELLTAHHE
                     AWVGGQYFKFASPPVYNSSVAFSTLPGNSQQALHRDDMDHHGKRPACDVGQYPIGRDSI
                     VTLFVADSRTTKQNGATRWIPGSHLQHHLGKPDLSKEVHIELERGDAFIMLASCYHAAS
                     ENLSDTDERIVYSAFTINSTYRQSENVFLSLPLECLREFSPWMQKRLGFSASSPLCGWI
                     DLTDPREVLNLPEPSDLERYH"
     gene            <11252..>12765
                     /gene="peniE"
     mRNA            join(<11252..11416,11485..>12765)
                     /gene="peniE"
                     /product="PeniE"
     CDS             join(11252..11416,11485..12765)
                     /codon_start=1
                     /gene="peniE"
                     /product="PeniE"
                     /protein_id="QDO73506.1"
                     /transl_table=11
                     /translation="MSAEYTCRSTNPWADSSTIYAGLVVNAVLDLDILHEKQKELISLW
                     PILGGTVVQSTKPWSFTCGSNVDFESRTLDETVSTHFPNNWGNMTGPSASTTLDPAIVD
                     AKFLFAIKPAPSTIFRIRVTVLRDATLVCFGITHQVTGAGGCFEVVSAFCDLLANRAIP
                     HFALPPDARGLKLSDHITGGDDNVTSDELGDFEPPEKNWNIGVVKAATMMWRVLIAQFW
                     KTLGLREKLTEKYIHLPGDWVDEVRNQAQKELSSLPESSDVELTRNDIISAWYLKTIHG
                     PSSSSGCDTTPVDFYVAINYKGLLNPNTTGGCSEKGPSAEQQQTQYLHHSVAIFRCMFS
                     AYQLQNDSISSIAWRIRRATLHYKQPSSIKKYVRFVEKNNSNLLVVDIRASNPFSMVGL
                     SSWTTYNYMALDFSGAIGDRKAPQDGVRVTFVNPLALSPISGLTLYTLKDGKGGYVIRT
                     ANTKTQWKQLEKSSSMENLFPVL"
     gene            <13820..>14827
                     /gene="peniF"
     mRNA            join(<13820..14572,14654..>14827)
                     /gene="peniF"
                     /product="PeniF"
     CDS             join(13820..14572,14654..14827)
                     /codon_start=1
                     /gene="peniF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /product="PeniF"
                     /protein_id="QDO73507.1"
                     /sec_met_domain="PhyH (E-value: 7.7e-23, bitscore: 70.5,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVSQQPLEPTPFGLHRVQAKTTSLEGILPLLTYHGGLIVEGLVS
                     QDILQDIEKELRPHFQQGWNTDPMFSQKTRVVCGLPGKSPTLINECFGHPLFTEVCDAL
                     ITSHSSSRFGEQRYDFRSPPVLGNTVAFSTLPGNAVQRMHRDDMDHHNMLPAIASDQYE
                     AGRDCVVTLLVAGTRTTKENGATRFIPGSHLQETLHIPDESQAVYIEMQPGDAFILLGS
                     TFHAGSGNVTDEEERILYSVAGVKSILRQTENIYYTLPLEKVREYSPWMQKRLGFSASS
                     PLGGHIDLKDPREVLGLPEPSDIQWFY"
ORIGIN
        1 ctaggccttc aggtcaatga gttcaacctg tcgggtcttt ctgatgaggt tgttttggtt
       61 tccaaagtac cgttcggtgg caaagctgcg gacaccgtta gtacctgact tttttgtaga
      121 ggtccaccct agcaagacgg agaatggtgt gattcttacc tccagtgcaa attgcctaca
      181 gcaacctcct ggcaggcctg aacgaacttc tgaacctgga gatcaagcgc ctcgccgtag
      241 aaagggagct ggttcaccgc aaggtgccat tcccgaaggc gcttttgaat tagcttatcg
      301 gtctcgttat acgcttcttg ctgcgtcatg ccacgctccc ggagaataat cacgatgtta
      361 tggatggctc ccatttccta tcgtgggtta gaaaatccgg tcttattaag gtggtgcgtg
      421 caaagtgagc tcaatgctcg cagtgggatt aaactcacgt attccttatg gtaggagagc
      481 acatcgttgt ggctggtccg ttcgcgtcag gtcatttgtt tcaaagaaga cagtgttgta
      541 gtatggggga tatcgggcta ctcttacagc actgtgatct cagcggcaag atccatgata
      601 gtcttcaccg agggatgctc gaagaattcg tcggggagac gcagatcgtg gtagtacctg
      661 gaaagtttga tcgtaagctc aattgaacgc ttaggcccag tctgcgtggc aaaaaggtgt
      721 atatctgggc acagtccata ctcagcaaat actatgcaag ggacaacccc gatcgattgg
      781 cggcgaaatg cgagatacgg atcgagttct ctggtgtcaa tatccgctcg gactccaact
      841 tgcccgacaa ggcctttgca gaattcttgc atcgcttctc tgaaccgtct ttggacacct
      901 agaggaaaag tttagcttct ggttgacgat gtcgtgggag gggggcagct taccagcaga
      961 ggcacgcttc attgatgaat gaaagttagt ggcaggctac aatatatgag tggaagaggt
     1021 caagttacct gagagatacg ttcccacact gagcggaaag cataacgaag ggctctcgct
     1081 cgtggcaagt cgtcaggata ctcatcgtcc ctaagaccga cagtcatgat ttgggtaaga
     1141 atatcggcct ctctctgcgc cttcgcctca tcctcgcaca gatggccctc atcaaattct
     1201 gcacgcatta ggtttagtac tcgccgctgc ttcaaggact ggtgaaattg gatttactca
     1261 cggtcatcga agtagaaaac ctacaccaat gcatttgtca gtataagagt cggcttcatg
     1321 aagttcagaa acatccacag gatgggggga attacccagt tacaccaatc gcaaatggtg
     1381 cggaattcag actttccagc atcggctgtc caccatgcgg cgaatagagc gaagtctgcc
     1441 ttggtgagcc tgctaagttc tttttccgtg ctcagggagt ataacctaga gaacttgtca
     1501 gcttatgctc gagtttattt caagtgtgag cagtagaaga gcagggatag ctatgcttgt
     1561 tactgacttc gcaaaccagg catcagactc tgctttgact tcggcatagt acggattggt
     1621 cttgggagct cggctgcaaa aagagacgaa caagtctggg agatagactg tggtttcccg
     1681 cagttcattg ctagaaatct cctcggcaac ttgggaaacc gtcttctcat tgtctgcgaa
     1741 gatctgcgtt gttggttgta taacctccat tgtgcttgtg ttggcaaagg ttgaaactaa
     1801 gtgtacagaa caggcttgat gtgtggaaat tccattgcgc ttgctgcgct ttatatctat
     1861 ctcttgaagt agctgacgac atacattgtg accttttggt ctatcatctc ccctcttcga
     1921 tcggcgcagt atctgcgata gtactggtaa ggcaacaaaa aagagcagac cagtctatgt
     1981 agtatttctc cttacttcca aggttgaaca gatcactgta aattatgcaa gactagcagg
     2041 tagcaaacat attctagttc caaaaaagac aacaagacac atattttctg caagcatatg
     2101 tggattgtgg cgtcaagcct ctgcatattc actgcatact gcttcaggtc tcaccacagc
     2161 tcagagggca ttgcagcagc gcagtggacg tctttcgtac ggcacaacat cattgtactc
     2221 gtatgattcc ctggctacaa gatcgttcag catacctatc cctcgcttaa agccaggtac
     2281 tcggtttcac aacatagctc acactcaatt gggggagcaa cacctcagcc agccctctca
     2341 ccgagggtgc agctgctgtt cacatgcaga ctggaaagta aagaaaatat atcagatatc
     2401 attacattcc cctcggcttt ctgggaattt tgtggatata tccattcacc ccctcaccga
     2461 tggactgaaa gttcttttca aaagaaattt catggagcta catgtacata catggacgcg
     2521 agattacttt catcgtgcgg gtctccctct cccttgctct cggttcttgc tttcgggggt
     2581 ccatttccag cgaagtgctc ctaatgccgc ctagcgtggt tgcgtgagac ttgtacgcag
     2641 tagtggagat gtgtgaatac gggaagtgca cacaatgtct cggcttaccc gaagatacct
     2701 tgtgagccat tacgtagggg ttgatgagcc agctggcgcg aaaggaacaa tatattctat
     2761 gtcaaagtta cctagtagct tgtaaattct gattcgcatg agtgtaattt gctttgtgaa
     2821 catttgctct tctaccgagt aggactcggg gaggcgggct ccgttagttg acactgtgcg
     2881 agagggagca catataataa aacaatagta ggattacaga gagataaggt agctattttc
     2941 tacagtacca agaccacaaa cttttgaatt aaatcaacaa acagccaatc tttaagttct
     3001 ttctttttcc tgacaaggag cttataaaac cgaaaagcag taaaaaagaa aagcacatca
     3061 cagcgtaaat attcagtcta ttcaaccgtt gctcaacgtc cgctcataca agtccgggtc
     3121 tctgagacca aaatgacctg agaccaaaaa gacgggaact taaggcttgc acacatccca
     3181 gatgttcgcc tcatcctgtc caatattgct gaattcttcc tccaagattc ggtaacgatc
     3241 ggcatcccga ggggtgaacg tacctttaaa cggcacaggg ccggcgagaa tgttttgaac
     3301 aatagcgtga gggtcaattt ccactttctt gcccttctca taggcgtggg taatgttgta
     3361 cgcccagaga gttcggctga tgataatgaa aagcgacctc ttcgcaatgt gctgaccggg
     3421 acagactctc tttccatatc caaacgcaag gaaaggaagt ttcgagtcct ccaaccagcg
     3481 ttctggaaca aaatcgtctg cgttctcaaa aaccttgtgg tccgagtcca ttgcccagtg
     3541 attggccaaa acgacagagt ctttaggaat gcggaatcca ttgtaaacgt cctctttcag
     3601 gttggagtgt ggcacaccga atgggaagat tggccgccag cgctggacct cgcggatgaa
     3661 cgcatgaagg taaggaagat tcggagagtc atcccatgtt gggagccgat cggccccgac
     3721 gactcggtca acctcctctt gaacgaggcg caccttctcc gggaacagaa tgcttgccat
     3781 gacgaagaat tcaaatgttt tcatagtaga gcctccggcc tcaataagga caccaatcag
     3841 atagatgacc tcctcacggt ctagcttgtt cgcatcttcg gaagtctgac tttccttaac
     3901 ccagttccag cctggctttt ggagagcctt tgcgtggttg tccaggaaga atttcattgc
     3961 gctgtcgtgg tatacctttc cttgcttctt ccagcgcata agcgcgctcg ggaggatact
     4021 aatggtaggg aagcaatcgg cgatgaggtt cttgggcttc tcgacattgg acgagattgt
     4081 ctccgtgagc tcgtcaatga agaggatgcg ctcgtcatag agctccggga tgcgttctcc
     4141 gtatgcgagg gtaaatgtaa cgctaatagt gtaccgatgg aagacttgca tccactcggt
     4201 cccctggacg gacatcagat cgtgtagcgc ctgcttgctt tcgatgtttt gaaggaactg
     4261 gtactttgct gccattcgag cattcatgaa tgtgctcagg agcgagtggt gggtcttcca
     4321 gcgctcgtca taggcgatca gagcgctgtt ggcatcgtta ctgaaggctt tggcaaccac
     4381 gaagttcgga cgcgagctgt agatgttgct ccgcttctcc aggagatctt tggcaacttc
     4441 gtgagacccg agactgatca cggtacgttg gccatattta agacccatga ttggaccgta
     4501 ttgattgtgc catttcttgt atgttcccca gaggttcgac gcggggaact ggtggaggtt
     4561 gcccaagagt ggaagacgag tgggtgcggg tggaagaggg agtcttttat cgaagagcgg
     4621 cctcaggagc aagtaaccta gaaacacgac ggcggcaata gacaggatgc gagtgcggtc
     4681 atactccagc ttcgccggcg cctcaatttc tggctgaggt agggtgatgt ttatcaagct
     4741 ctgcacggta tccatgattg ctaattgata ttttgcggac aatggttgga atcttgatgg
     4801 gggacaaggt gagaaatagc caacagaaca taggacaggt cactgcccta attcccgttg
     4861 cacactacaa attatgatat caatgcatgt ctgtcgctcc tttcccagta ttaggtggtg
     4921 ctgatactca agttatccct tgaacaaaaa gtgatatttt atgtgcatgc tttatgcaag
     4981 ctagttcgac acagcacgat atctacctcc cccttgctct gagcataaaa ttggtgagac
     5041 tctcgggtgc aaacttattg aggtctccac ttgtactccg tacatccttt cagggttcca
     5101 atttgggaaa aatcaaaata agatcaaaaa cagacagaga agacgtgatt tatgtccttc
     5161 atgcggagta cctgcactcc ttactccgta tacccctgta aaataggatg acccctcacg
     5221 tcacacggca tttcacacaa cacccgaaac ggaatctatt tctcctatgc tctcgtcctg
     5281 atatgaaatg ggccgaacct ttcgggtacc cgcattctcg ctgaccgacc ccggggtggt
     5341 ctgccgtccg gtgatattgc gtaataattc caattcgtgg tgggtcggtt ttcgaagagg
     5401 cggatccaac cttatcggca ttacccacac ccccactcgt agacccttga accacttggc
     5461 tcaactcaac ctcgcctgag acctcggtag agactgaatc tctgtacatg aaagggaagc
     5521 ttctcctctc tttttgcgct gcctagagat gatacagatc tatgggttca tgtgaaatta
     5581 ttcgtgcact ctatctagcc cggggcggtg tcggagagtg cggttggcgc aatcatgtac
     5641 gagcaaatat ctcgaatggc tcgtcctgcc tgcgacctct gttcttggtg gggttgtaag
     5701 aatgtagatc ttttggcccc ctcatcttaa cccggaagga ggctagtaag aagttttgta
     5761 ggtttatcgc agattgtcat tgtgcataag gattacgtct ctctttttaa tgatatcaag
     5821 tggcgatact gcagatctac atcttcacgc cagaattgat catgtattct gtccattcta
     5881 tgctgttcct aggaagtggg gccagatcca gaccgtatcg acaatgcatg gacaaatgac
     5941 gagattggct cgccctacac atgagcaccc tccttacttg gtctatcgat ctggttctcg
     6001 tgtatgccag gccattttct gggatcaata gttccaccaa cccacaagag ggattagcag
     6061 cgctagaaac acgcaagtgc aaggatgggt gcaaagcaat cgatcaatga ggagagcgag
     6121 gaaaccacag acttgatgta ctactgacgc ttttgtgtgt acaagctttc cagtagaacc
     6181 tgtttatctg aaatggttac tgttttatag tcatacagaa ctaagagatt tcctttaatg
     6241 ttcaccattg ttcttcaaat ctgacctcat ttgaagctct caataaattc tagttatggg
     6301 ttcaatttca ccattaccgc tcactcctga tgcgagttgc tgccctcgag aggttatctt
     6361 agaaaagtat cagcaagaac gaaagaagcg ccagttgaat tgtgtgcctg acaacgaagc
     6421 aaccgaattg caccacaagt atgccccagt gcaaggagtt gaccagccgt cttacactcg
     6481 ctcgcctata atcaccgatt ccaaagttgt catcataggc ggtggattag ccggcctagt
     6541 aaccgctgtc aagctcaaaa cgcaaggaat caatgatttc gtgatactcg agaaaggtgc
     6601 agagtgtgga ggaacgtggc attggaatca atatcctggt aggtaccacc cacatgccag
     6661 cctaacgatc accagcgaga gactaactcg gcgggggcca aattaggtgc ggcgtgtgac
     6721 attgaatccc ttatctacct gccactcctc gaagagaccg gatacgtgcc acaatcgagg
     6781 tattcgtcag gggccgaaat ccgtgcccat gtcgcacgga ttatcctgaa atggaacctc
     6841 ggggagcata tatgtccgct tactcaagtc acttcgacaa agtgggatga atcaaagctt
     6901 cgctgggagg tccagacgga ccactcggat agcttgacgt gccaattcct ggttcttgca
     6961 acggggcttt tccatgagcc aaaccttccg cggattccag ggagtgagcg gttcaaggga
     7021 gaccagttcc acagtgggcg ttgggactat gccgttaccg gtggcgatcc tgcgggctct
     7081 gttcccatgg acaagctcgc taccaagacc gtgggggtaa ttggtactgg ggcatcaggt
     7141 gtgcagattg tgcctcggct ggcacaagat gcaaagaaac tctatgtttt tcagcgaacg
     7201 ccatcctcca ttactgcccg cgataactat acaatgaccc cgcttatgac cgagcctgtc
     7261 attcaaaagc cgggatggca gagggcgcgc atggtccagt tctgcgaaat gctcgaagcg
     7321 gaggagcacg aaatgtcaga caaagacggg actgtcgcag aaggctttga tgctttgagc
     7381 ttgcgcaaag ttctcaacgg gatgaggaag gacgatgtgg cccccgcgca aatgggggaa
     7441 ctgtacgccc gagcggatat cagcctcatg gaaagcatca ggaagcatgt cagcaacact
     7501 gtggatgacc acgaaacggc agaaaagctc aaaccgtggt atccattcct ttgcaagcga
     7561 ccagtattcc aaaatgatta tctctcttct ttcaacaggt ccacagtgga acttgtcgac
     7621 acgaatggtc agggcgtctc ctgtctgacc gagaaaggag ttgttgccaa cggtaaagag
     7681 cacgaggtgg atcttctcat ctacgccacg gggtttgatt acgagattgg cactcccttc
     7741 taccagcgga ccagaattca cgtttttggc tcccacggcc aaactcttga tgatgcatgg
     7801 gcagatcaag gaccgtccac tctgtttgga atccatattc gcgactttcc caacttgttg
     7861 tatataggac catgccaggc tggcgtcacc ttcaacttca cgcacacaat ttacgaagct
     7921 gccgatcata tatctcatgt gattggcgat tgtctgaagg acggcgcatc attccaagcc
     7981 atacaaccgt cgattgaggc gcagagcgat tgggtcaagc agaccgagga aggaagtgag
     8041 atgaggctgc agtatgcaca gtcctgccca ccagggtact tcaatggtca cgggaggccg
     8101 gagaagattc ccgcaagatg gggatactac cctaagggga tcaaagcttg ggcaaacgcg
     8161 atgagggagt gtagggctga gggtatgaag gggttagaaa gatggtaggt cacgctacgc
     8221 aggtctgtag ggtccagggt tgttttcggc atttcaatca aatacatcca tccaattctt
     8281 atttggaact gagcttacac cgtttcatac actgtcgtat gcgacatatt gtaaaattgc
     8341 ggagaagcat tatggtacgg agtacagtaa ttcatgtttt gtcgagacga ggagaagaag
     8401 agaagggaag agagggaagc tctcctcatc tacatccaaa acctgctgga agcctggcaa
     8461 accaggtaaa caaacacctg acacccaacc attcaaccat tcaacggatt ttgaaaatgc
     8521 tcagctgtgc tcttatccag ccactttgtg aggcttaatc tattttccca atggtacata
     8581 cggagtactc cgtattaatg atatctctcc aaatcacttg gctctggaag gttcaggacc
     8641 tcccttggat ctgtcaggtc gatccaaccg caaagtgggc tgcttgcact gaagccaagt
     8701 cgcttttgca tccaaggaga aaactcccgc aaacattcca acggcagtga cagaaagaca
     8761 ttttcagact gtgcgataaa attgatggtt agatggttct gatagattga atggtcttac
     8821 ctacctgtcg atatgtggag tttatggtga aggcggaata gacaattcgt tcgtcggtgt
     8881 cgctcaagtt ctcggaagct gcatggtaac acgaagcgag catgatgaat gcatcaccac
     8941 gctcaagctc aatgtggacc tctttgctta ggtcgggctt gccgaggtga tgttgaagat
     9001 gggaaccggg aatccatcgc gtggctccat tctgcttggt cgttctgctg tctgccacaa
     9061 acaaggtgac aatgctgtcc ctaccgatgg gatattgacc cacatcgcac gcaggccgct
     9121 tcccatgatg atccatatca tcgcggtgta gcgcctgctg tgagttgccc ggcagagtgg
     9181 aaaatgcgac ggaggagttg tagacaggtg gcgatgcaaa tttgaaatat tgacccccaa
     9241 cccatgcttc gtgatgggca gtgagaagct cgtcgcagac agcggtatag acagggtttc
     9301 caaagatctt ctcgacaaac gtgcgagact ttctgggtat tgagcacaca gttcgtgtcc
     9361 tctcacaaaa cggcccttca tgatttcccc tcttgaagaa tggttttatt tcgcgtccaa
     9421 cctgctgaag aacctcctca gataccaaac ctcggactat cacccctcca tggtgtttca
     9481 tcacctttgt tatctcctca accggcgcgg ttgcatccac actatggaga ccaaattccg
     9541 gctgagcagt aactgtcatt ttcgagaaag aactgggtaa ctcgtggcaa tccgttcaag
     9601 gcaaaattaa atgaccagct aattgtgtat gagcaatgtc tatggacaga ttttgttatt
     9661 gggtggtaat aatgatcctt ttctacctac cacgctgcct gcttgaaaac attgaccctt
     9721 gacagatttc tcgctcagct tggccgatca ccatttgacc cacttgagct gtaaggatga
     9781 taacaaggaa tggatcatct atgtagcttt gtgcatcatt ccaaggttct cctccgtaca
     9841 aatggtcgag atgttttggg tcaccattcc gatcattgcc gatccgcagt cgaacctcgg
     9901 agtgaccgac attcccatac tgaactttct ggaagtccaa taagcaatta ttatgactat
     9961 tataaatcca actctgcaag ggaaatacag attgtacact cttggcacag gaaaaatgtc
    10021 ggcaccggtg tttgcctgat ttgcagggtc cccgctagcg tagatagatc tagatctctc
    10081 ctctctctct ctctctctct cattcttccc ccaggtctcc cacaatacat acaattgatg
    10141 ctacatactc cgtactgctc ccgctcttcg ctcgataaag aaacgctaac tgcacactcg
    10201 ctagcacaaa agttgctagt gccacttagc cttcattcca aggtttttag gcaagcgttc
    10261 gtcgtgcatg tgatatcatc atactgtcta tcacagcgtt gatcatgaga tacttcgtac
    10321 agagccgtca ctaaatatgt gacgtaatca gaacccgatt tttttagata aaatcaaata
    10381 tagaattact ttttgctaaa tattctgtat accatattct gtgcgtgcaa gccaaccgct
    10441 ccactttcaa gggatcagat attcgccaag agaattggtt cgctgcagtt ctctcacaca
    10501 ccgacatctc accagctcct atctcactct taagcttggt aagtggcggc taccacgagc
    10561 ccgtcacatt ggctctgtcg cctaaacacc ggctctatga atctgagctc atccatggtc
    10621 tattcaatga tgctgtgtgg ggaagtctac taggcaatat gcataaaaca gtgatctgta
    10681 tgatgtgtaa gcagagaaga agaaaagaga gaaagagaga gagagagaga tcgatctttg
    10741 aacatgagag gcaaacagtg acatatggca tcctccctga ccatagtctc taacatggtg
    10801 gaaccttgaa agtgaccttc gcaagcgtcc ttgccttgac gggggactta atctattgcc
    10861 gtgacctgcg gctcctacat agaaccaata tacgtctatt tctcccttcc atgtctcaat
    10921 ggttctattg ttctcttgac atgtctatcc gtctgtaccg ggtgcttatc acctattcat
    10981 tattccgaca ttcagaacgc agtccataaa gtaagggagt tgcagtagcc gagaacccca
    11041 acatatgaaa cccgctctag accgtaaaca cctgatttgt ctttcaagga cagaatataa
    11101 gtcttgaatc taaccattgt ctcgttcact cccgcgtgtc gttaaaggca ttcatatatc
    11161 gaactgcttt tgccccggaa tataaaaatc atccaatttc agcttcgtta tttgcgaaaa
    11221 gcgaattggc aacctcaccc tgccgaatac aatgtctgcc gaatacactt gccgaagtac
    11281 caacccttgg gccgacagta gcacaatata tgcaggattg gtggtgaatg cagtgctgga
    11341 ccttgatatc ctccatgaga agcagaagga gcttattagc ttatggccta tcttgggtgg
    11401 tactgtggta cagtctgtaa gtattccttc ctcaactggc acacgtcgaa tctatccgga
    11461 atctaactaa cttgcaacca aaagaccaaa ccatggtctt ttacgtgcgg ctccaatgtc
    11521 gactttgaaa gccgaactct agatgagacg gtaagcacgc atttccccaa caattgggga
    11581 aacatgacgg gcccatcagc cagtacaact ctagaccctg ccatcgttga cgcgaagttt
    11641 ctctttgcta ttaaacctgc cccttcaacg atcttcagga ttcgggtgac tgtcttgcgg
    11701 gatgcaacgc tggtttgctt cgggattacg catcaggtca ccggtgctgg gggctgcttt
    11761 gaggttgtca gcgcattttg tgatctgctg gctaatcgag caattcctca ttttgctctc
    11821 cctcccgatg cacgaggact gaaactgtcc gatcatatta ctggtggtga tgacaacgtc
    11881 acctctgatg aacttggtga ttttgagccc cccgagaaaa actggaacat cggagtcgtc
    11941 aaagcggcca cgatgatgtg gagggttctg attgctcaat tctggaagac tctcgggctg
    12001 cgggaaaaat tgactgaaaa atacattcat cttccaggtg actgggtgga tgaagtccgt
    12061 aaccaagcac agaaggagtt gtcgagtttg ccagaatcat ctgatgtcga gcttacccga
    12121 aacgatatca tctcggcctg gtatctgaaa accatacatg gaccatcatc atcttccggt
    12181 tgtgacacca cgccggtgga cttttatgtg gcaataaact acaaggggct tctcaacccg
    12241 aatacgactg gaggttgctc tgagaagggc ccttccgcgg agcaacagca gactcaatat
    12301 ctccatcaca gtgtcgccat tttccgctgt atgttctcag cctaccagct tcagaatgat
    12361 tccatttcca gtatcgcatg gaggatccgt cgcgcgacac ttcactacaa acaaccctcg
    12421 tcgatcaaga agtacgttcg ctttgttgaa aagaataatt ccaacctcct agttgtcgat
    12481 attcgtgcaa gcaacccctt ctccatggtg gggctttctt cctggacgac atacaattat
    12541 atggcactcg acttttctgg cgcgatcggt gatagaaaag caccacaaga tggagtccgc
    12601 gtaacctttg tcaatccgct cgctctcagt cctatctccg gcctcacact ttatacactg
    12661 aaggatggaa aggggggata tgtgattcgt acggcgaata caaaaacgca atggaagcag
    12721 ctagaaaagt cttcaagcat ggagaacctg ttcccagttc tgtagcgcag cgccacaaga
    12781 acgctccttg agcttttgct tagatttctt gtgattcaaa tgtcactttg gtgtttacca
    12841 agctttccac caacataaac ggatctgcat catataaatg agatacttga attttctttt
    12901 gttcttacgt cataagcacc tctaatggac agagaattag ggatagagga ttgtcgatga
    12961 tctttatttc ttctttctct tctccattct cgcggcctta cttccattac agctccatcc
    13021 ccattttgag gtaagcccta cgtcgctgta ctgctacatc gctgcatcga tactgttaaa
    13081 tttgacatcg ctgcctcagc tgtcactaag ccttcccacc tattctactg cgagaatcga
    13141 agctaaaact acatagaaat atacctatcg cggagctttt ataaaataac attttaaatc
    13201 aatctaaata gcctgtgaag agttaaagat aatggtttgt gcggttgtta aatctgaata
    13261 tagctgtaac gcctgggcca ataagggctg agcattttgg ttggttttaa tagcttcagt
    13321 atcaccgaac gccggtcgca atacttagta tgtcacgttg cacaaagcga tttaaagtca
    13381 ggcatactca ggtatcctca gcgtagtttt caccccttgc acgttatgcc gctccgtact
    13441 ccatatagtc caaggacatt tgcatgatgc aacaagaagc taccagatct gtcttgtgca
    13501 tgtgcatgat gcaacaagaa attaccagat ctgtcttgtg aaaccctgtc tatgtatgcc
    13561 tgccacgtca tcaagcattg tggtctatca tcttctttcc cgtgcttcgt tttcgcttgc
    13621 acgagtgctt ctagcttcgg caaaccctgt cccatagctg atcatgcggt gtgtaaccca
    13681 ctgccgtcaa cttttccaac atacaaatac cagtcccagt aaggggccag aaaagtatta
    13741 tcattgaagc tcaatttact tttctattcg atggggctag aatcccagtg aaaccaattt
    13801 ttgtcaacaa aaatcaacta tgaccgtgtc tcagcaacca ctcgaaccca ccccattcgg
    13861 gcttcataga gtgcaggcaa agaccacttc tcttgagggt atccttccac tgctcaccta
    13921 ccatggtggt ctgatcgtcg agggcctcgt atcgcaggat atcctccagg atatcgaaaa
    13981 ggagctccga cctcacttcc agcagggctg gaacactgat ccgatgtttt cccaaaaaac
    14041 ccgcgtggtc tgtgggctgc ctggcaagtc gcccaccctg ataaacgaat gttttggaca
    14101 tccactcttt acagaggtct gcgacgcgtt gatcacctca cactcctcat cccgcttcgg
    14161 cgagcagagg tacgacttcc gctcgcctcc cgtcctcggt aataccgttg ccttctccac
    14221 cctgccaggg aacgctgttc agcgcatgca tcgagacgac atggaccacc acaatatgct
    14281 acccgccatc gcctctgacc agtatgaggc tggccgtgac tgtgtggtca ctttactggt
    14341 cgcgggtacc cgcaccacaa aggaaaatgg tgccacacgt tttattcctg ggtcgcattt
    14401 gcaagagaca ctgcatatcc cagatgagag ccaagcagta tacatcgaga tgcagccggg
    14461 tgacgcattt atcttgctgg gaagcacttt ccacgcggga tcaggtaatg tgactgatga
    14521 agaagagcgt atcttgtact cggtcgccgg tgtcaagtcc attctgcgcc aggttagtat
    14581 cagacatttt ttacactttc tttgcttgtg gaatcgagct tggcattcca ttagaggctg
    14641 actagacttg cagactgaaa atatttatta tacccttcct ttggagaagg ttcgcgaata
    14701 ctccccgtgg atgcagaagc ggctcggctt cagcgccagt agtccccttg gtggtcacat
    14761 cgacctgaaa gatcccaggg aggttcttgg acttcccgag cctagtgaca tccagtggtt
    14821 ctactag
//
