LOCUS       BGC0002575              8828 bp    DNA     linear   BCT 10-FEB-2016
DEFINITION  Streptococcus suis strain LSS65 genome assembly, contig:
            ERS132427SCcontig000001, whole genome shotgun sequence.
ACCESSION   BGC0002575
VERSION     BGC0002575
KEYWORDS    .
SOURCE      Streptococcus suis
  ORGANISM  Streptococcus suis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 18:02:06
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1098)
                     /EC_number="2.7.13.3"
                     /codon_start=1
                     /gene="phoR"
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 100.9; E-value: 1.5e-30)"
                     /gene_kind="regulatory"
                     /inference="ab initio prediction:Prodigal:2.60"
                     /inference="similar to AA sequence:RefSeq:YP_001200469.1"
                     /locus_tag="ERS132427_00205"
                     /product="NisK"
                     /protein_id="CYV09467.1"
                     /transl_table=11
                     /translation="MERKLDFKTLVKKTQWTIIKQFCLSVIVAYIFPISTISIDIHSET
                     QSIASDLLGIFFNVFSWVYICISLIIIVSVNIKALLKRVKQEMEIVYHGSMWLTSVNTS
                     SKLTILEFIETNKHIELMQQRIKNMIQVEKDQKEDILFKVSAMAHDLKTPLTVIKGNSE
                     LLQFAPLSGIDVQCLRDIERASNQLDNYFNQLINYSKTFYSNQISFHQYSISNLSKILE
                     QECAYLIGDSIDYKYETKIGRDCNIELDLDLIIRSVSNIVNNAIAYADDVKKKIRVILE
                     LEDSSISLSIWNNGSKFSDDVLENFGKLFYREDTSRNSQFEHFGIGLAFVKQVMSIHSG
                     DIQLQNKKNGAMVKLIIPIKNSDCT"
     protocluster    1..8828
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4010:8227]"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4011..8227
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     cand_cluster    1..8828
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..8828
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002575"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..8828
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..1098)
                     /gene="phoR"
                     /locus_tag="ERS132427_00205"
     gene            complement(1083..1766)
                     /gene="arlR_1"
                     /locus_tag="ERS132427_00206"
     CDS             complement(1083..1766)
                     /codon_start=1
                     /gene="arlR_1"
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 159.2; E-value: 2e-48)"
                     /gene_kind="regulatory"
                     /inference="ab initio prediction:Prodigal:2.60"
                     /inference="similar to AA sequence:RefSeq:YP_002740532.1"
                     /locus_tag="ERS132427_00206"
                     /product="NisR"
                     /protein_id="CYV09491.1"
                     /transl_table=11
                     /translation="MKEKKIYQILAIDDDESILRLIKNSLERSEFEVTTRKEVGNIDIC
                     SFVGFDLILLDIMMSIDGLEICKSIREQIDVPIIFVTAKQLDSDLARGVKAGADDYIKK
                     PFSITELVARVRMHIQREERNRKNNKEICTKKMIINASKQEILIEEEIISLTKREFTIL
                     YTLASNPKRVYSVEELYERIYPSESEAQFRSIAEYIYQIRSKLKPFSINPIKTQWGGGY
                     SWNEN"
     gene            complement(1797..2504)
                     /locus_tag="ERS132427_00207"
     CDS             complement(1797..2504)
                     /codon_start=1
                     /inference="ab initio prediction:Prodigal:2.60"
                     /inference="similar to AA sequence:RefSeq:YP_003024826.1"
                     /locus_tag="ERS132427_00207"
                     /product="membrane protein"
                     /protein_id="CYV09504.1"
                     /transl_table=11
                     /translation="MNSFRSEYLKFIYNKWLLLTVLATIILVPLFVIFLHETPSYITEN
                     YALTQILESFYLGQAGIIIITILFIGQEFNDSTLRSSLLANPIRWKFFFIKLIVILSIS
                     VLVWSLVTVCTIFVVYIFYSLLIPGFIYTIAVRIMLVSIGLILICFSLVLITRSIVVPM
                     GISLSFLLGLGQMLLQFSDAFLYFPIISTMNSFFTTENQPYLPSTIGIAIQFLWGILLL
                     SFSILLFRKRIVR"
     gene            complement(2501..3292)
                     /locus_tag="ERS132427_00208"
     CDS             complement(2501..3292)
                     /codon_start=1
                     /inference="ab initio prediction:Prodigal:2.60"
                     /inference="similar to AA sequence:RefSeq:YP_003024827.1"
                     /locus_tag="ERS132427_00208"
                     /product="membrane protein"
                     /protein_id="CYV09523.1"
                     /transl_table=11
                     /translation="MMSSIKSYNILSELYKIFYSRSTQIVLPIVFILQPLLSYISSKQI
                     LTVGLNATPETNSSLAEPIPPIEYIGFDAILLGLFAIIILGAILGNMEYKNSSLRTSLL
                     LCSNKVVFFVIKFIVTCVFIFVVSFVSIYLSIVSAQFGLGREGLNPLLLNKNVWYFILL
                     GSLSWSLLTVLSYSIAFYFKSSLGALLFLLPQVYNLGSFLADRIQLAKYLPVSLGQDLI
                     ATSPLKITTPGRSVLFLSIWVLVISSFAYYKFLKEDVGNVR"
     gene            complement(3282..3998)
                     /gene="ecsA_2"
                     /locus_tag="ERS132427_00209"
     CDS             complement(3282..3998)
                     /codon_start=1
                     /gene="ecsA_2"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 162.9; E-value:
                     1.6e-49)"
                     /gene_kind="transport"
                     /inference="ab initio prediction:Prodigal:2.60"
                     /inference="similar to AA sequence:RefSeq:YP_002740535.1"
                     /locus_tag="ERS132427_00209"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="CYV09544.1"
                     /transl_table=11
                     /translation="MTNKIEIRDVTKTYKDGDILKNVSFTAEEGEVTAFLGPNGAGKSS
                     TLRILLGLDRPSSGTALIGGKKYCDFERPLLTVGASFDGVGAPNDRTVFQHLKIAAASN
                     GIDLSRISEVLSITDIEHKRYSKIGNLSLGEGQRLGIATALLGKPQYLILDEPTNGLDP
                     SGIRWFRNFIREQASAGKTVLLSSHILSEVEAVTDKVVFINKGSIIASGTLNNIMNGFD
                     NLEDVFFHLTGGDYDE"
     gene            complement(4011..6233)
                     /gene="lmrA"
                     /locus_tag="ERS132427_00210"
     CDS             complement(4011..6233)
                     /EC_number="3.6.3.44"
                     /codon_start=1
                     /gene="lmrA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 277.5; E-value:
                     3.7e-84)"
                     /gene_kind="biosynthetic"
                     /inference="ab initio prediction:Prodigal:2.60"
                     /inference="similar to AA sequence:RefSeq:YP_002740536.1"
                     /locus_tag="ERS132427_00210"
                     /product="ABC transporter NBP/MSD fusion protein"
                     /protein_id="CYV09559.1"
                     /sec_met_domain="PF13471 (E-value: 3.7e-20, bitscore: 61.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDMQLNQESYSYVQLKYRLLAQIALLISYPLTKLSPTRIEFLINK
                     LSDSKLSATVNEVVLARDAICTVSRKCRNQDGCVKISLGVIMFLLLLKKRASWCTGFAM
                     NPFRSHAWVEVNGNPIKELEEVSSYERVVKTLDDKNEERKHMITEDIEKVNDTMTNVKF
                     RDLLALIENKGKYFLIVLCLGILTSILTLLQPELLSKVISQKGVNLFNNSTMYTLIAIT
                     VGTTIISSLQYYFLQLMGESAVFQSRKNLIIQFLKLPIYKYNDLSAGDLISRFSSDTSK
                     LRAGIIQSTVALTSGLFLSLGAIFTLFLKDTYLAIITIISISLSFLFILLMSSLIQTAS
                     YKAHQGLGKMTAYLNRLIVGIRTIRSTNETNSELSKMLSEAQEVKNLGIGVARVQSIMT
                     PISNFSLQLCGIIILGVGGYRVSTGQMSIASLTSFMLLMYIAISPVGQIFSSVTTISEA
                     LGALGRITEIIDLPKEEDNDIILNLETKSDRSKAIEFANVTFSYDSYKFQDIQSDDNYI
                     LKDITFEINSGDYVSIVGPSGAGKSTLLYLIERFYDITSGSIKVFGQDFRTMSRETLRS
                     NISYVEQNSPLVAGTILENLKMGNTNVTYDECCDALKKVGLEHLIQRGASGVESQIGEG
                     GFNLSGGERQRLAMARAILSDAKILLLDELTSNLDSLSEKKMKEAIKNMRGERTIIMVA
                     HRLSTILDSDEIFVLEHGRLVGSGTHVELLESVPLYKELAKEQFLV"
     gene            complement(6237..6488)
                     /locus_tag="ERS132427_00211"
     CDS             complement(6237..6488)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Subtilosin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thurincin_rSAM_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.60"
                     /locus_tag="ERS132427_00211"
                     /product="SynChlorMet cassette protein ScmD"
                     /protein_id="CYV09580.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.7e-26,
                     bitscore: 80.5, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Subtilosin_rSAM_RRE (E-value: 2.2e-10,
                     bitscore: 30.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2e-16, bitscore: 49.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Thurincin_rSAM_RRE (E-value: 2e-09,
                     bitscore: 26.9, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFNKGSKTRLKIIKQDNGAIVFDKDQGIYFQTNDVGVKILELLSK
                     NKNEEEIVSAISAAYSIETDVAKQDVKDFIQSLKKGGI"
     gene            complement(6500..8227)
                     /locus_tag="ERS132427_00212"
     CDS             complement(6500..8227)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_kind="biosynthetic"
                     /inference="ab initio prediction:Prodigal:2.60"
                     /inference="similar to AA sequence:RefSeq:YP_001200476.1"
                     /locus_tag="ERS132427_00212"
                     /product="asparagine synthetase"
                     /protein_id="CYV09597.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.8e-26, bitscore:
                     83.0, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLNKYFFEKYSDKKIIFLTKNLYRTVSVNNTKIYCLEDYVEEICS
                     IIEQNDISSFEETISLLQDCVINGLIIIEMAERTYVISPYLDSRLSWFENSKNIIFSDS
                     SVEIAKYLKLKLSTKRLASQFVFGLPYYPFQTISLWEELVNIKPLNYLEITEKGCLEKK
                     IPSYEVDTKDFNQLIIKIKEEFLNSINHDLNMGNEVSSDVSGGVDSATIAFTLNKMIPD
                     FSILHAESSATANSDTKWATFIAKNLGRELKKFDSIEITEKRFAIEEGYINGIIPSFPL
                     LWADSEGYLKSVITYQEGKKHPTHFLGIGGDELFTPMPSNPWSIVRQENLGGLLYALKY
                     SLIMRRPFFSCLLDLLDKRGYLETMTQNLEIVFNESSEPIKRELGWMDGLQVPSWLSEK
                     SKKESQSFLNSLLFSNSEPIITDRTTFQMIQSLIFQKSVLRQIQLTTNSIYWATPFLHK
                     KLVEICLQIPAKYKVSSKLTKPVLQKALKGIVPIEVFNRGFKGDYSDALYSGYREAVRK
                     NFHKLEQFEVVKMGIVDVEKLKLELSLPAGNPNKIDYFERLCSVERWIRQIKLYMKNE"
     gene            complement(8343..8471)
                     /locus_tag="ERS132427_00213"
     CDS             complement(8343..8471)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (lassopeptides)
                     predicted lassopeptide"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.60"
                     /locus_tag="ERS132427_00213"
                     /product="Uncharacterised protein"
                     /protein_id="CYV09608.1"
                     /transl_table=11
                     /translation="MKYCKPTFESIATFKKDTKGLWTGKFRDVFGGRAIVRVTIEF"
     CDS_motif       complement(8415..8471)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKYCKPTFESIATFKKDTK"
                     /locus_tag="ERS132427_00213_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       complement(8343..8414)
                     /prepeptide="core"
                     /locus_tag="ERS132427_00213_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="-7.60"
                     /molecular_weight="2607.0"
                     /monoisotopic_mass="2605.4"
                     /core_sequence="GLWTGKFRDVFGGRAIVRVTIEF"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MKYCKPTFESIATFKKDTK"
                     /leader_location="[8414:8471](-)"
     gene            complement(8706..8828)
                     /locus_tag="ERS132427_00214"
     CDS             complement(8706..8828)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (lassopeptides)
                     predicted lassopeptide"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.60"
                     /locus_tag="ERS132427_00214"
                     /product="Uncharacterised protein"
                     /protein_id="CYV09633.1"
                     /transl_table=11
                     /translation="MNYTKPVIEKISTFKNGTAGLVAGSFRDIFGGRALFLIRI"
     CDS_motif       complement(8772..8828)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MNYTKPVIEKISTFKNGTA"
                     /locus_tag="ERS132427_00214_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       complement(8706..8771)
                     /prepeptide="core"
                     /locus_tag="ERS132427_00214_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="-8.60"
                     /molecular_weight="2260.7"
                     /monoisotopic_mass="2259.3"
                     /core_sequence="GLVAGSFRDIFGGRALFLIRI"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MNYTKPVIEKISTFKNGTA"
                     /leader_location="[8771:8828](-)"
ORIGIN
        1 ctaggtacag tcactatttt ttatcggaat gattaattta accatagccc catttttctt
       61 attttggagt tgtatatcac cagaatgaat gctcattact tgttttacaa atgccaaacc
      121 tattccaaaa tgttcaaact gtgaatttct actagtatct tctcgataaa ataattttcc
      181 aaaattttct aaaacatcgt ccgaaaattt ggaaccatta ttccaaatac ttaaggaaat
      241 actactatct tctaactcca agataactct gattttcttt ttaacatcat ctgcataagc
      301 tattgcatta ttgacaatat ttgatactga acggataatt aaatctaaat ctaattcaat
      361 attacagtct cgccctatct tagtttcata tttgtaatct atgctatctc caataaggta
      421 tgcacactct tgttccagta tttttgataa attactgata ctatactgat gaaaggaaat
      481 ctgattagag taaaaagttt tagagtaatt aatcaactga ttaaaatagt tatctaattg
      541 gttgcttgct ctttcaatgt ccctaagaca ctggacatca ataccagata aaggtgcaaa
      601 ttgcaacaat tccgagtttc ctttgattac agtcaaaggc gtttttaagt catgtgccat
      661 cgctgaaacc ttaaagagaa tatcctcctt ttggtctttc tctacctgaa tcatattttt
      721 tattctttgc tgcattagtt caatatgttt gttagtttct atgaattcga gaatcgttaa
      781 tttagatgat gtgtttactg aggtcagcca catactacca tgatagacaa tctccatttc
      841 ttgctttact cgtttcaaca aggctttaat attaacagaa actataataa tcaaagatat
      901 acaaatataa acccatgaaa aaacattaaa gaatattcct aacaaatcac tagcgattga
      961 ctgagtttct gaatgaatat caatagaaat agtcgatatg gggaaaatat atgctacaat
     1021 cacactcaaa caaaattgtt taataatcgt ccactgcgtt tttttgacca aagtcttaaa
     1081 atctagtttt cgttccaact atatccgcct ccccactgtg tcttgattgg attaattgaa
     1141 aagggtttta attttgaccg aatttgataa atatactcag caatagaacg aaattgtgcc
     1201 tctgactccg acgggtatat tctttcatag agttcctcta cggaatatac tctcttcggg
     1261 ttgcttgcta aagtatacaa aattgtaaat tctcgctttg tcaatgatat gatctcttct
     1321 tcaatcaaga tttcttgctt gctggcatta attatcattt tctttgtgca tatctcttta
     1381 ttatttttac gatttctctc ctccctttgg atatgcattc taacgcgagc aactaattct
     1441 gtaatactaa atggtttttt tatataatcg tccgcaccag cctttacccc tctagccaaa
     1501 tcgctatcca attgcttggc tgttacaaaa attatcggta catcaatttg ttctcgaatg
     1561 gatttacaaa tttctaaacc atcaatagac atcataatat ctagtaaaat taaatcaaag
     1621 ccaacaaatg aacaaatatc tatgttacct acttctttcc ttgtcgtaac ttcaaactct
     1681 gagcgttcta aagaattctt tatcaaacga agaatacttt catcgtcatc aatcgctaat
     1741 atttgatata tttttttttc tttcataatt aaataatatc acaaaataca aaatttttat
     1801 cgtactattc tcttcctaaa cagcaaaata gagaaagaca acagcaaaat cccccataaa
     1861 aattgaattg caatacctat tgtagaaggt agataaggtt gattttcagt cgtaaaaaat
     1921 gaattcatgg tagagataat cgggaagtag agaaaggcat cgctgaattg cagaagcatt
     1981 tggcctaacc ccaacaagaa agacaaggat atccccattg gaacaactat actccttgtt
     2041 ataagaacta aactaaaaca tattaatatt aaaccaattg ataccagcat tattcttact
     2101 gcaatggtat aaataaatcc gggaattaat agactataaa aaatatatac cacaaaaata
     2161 gtacagacgg taactagact ccaaactaat acagatattg ataatataac tattaatttt
     2221 ataaaaaaga atttccatcg tattgggtta gctaataaac tgcttcttaa agttgaatcg
     2281 ttaaattctt gccctataaa tagtattgta ataataataa tcccagcttg tccaagatag
     2341 aagctttcta agatttgtgt taaagcataa ttctcggtta tataacttgg agtttcatgt
     2401 aaaaaaataa caaataaagg tactaaaatt atagttgcta gtacagtcaa taatagccat
     2461 ttattataaa tgaactttaa atactcactt ctaaaagaat tcatctaaca ttacctacat
     2521 cttccttcaa aaatttgtaa tatgcaaagc tactaattac tagcacccaa atactcagaa
     2581 ataaaacact gcgtcctggt gttgtgattt tcaaaggaga cgttgcaatt aaatcttgcc
     2641 ctaaagatac tggtaaatac ttggctagct gaattctgtc agcaagaaaa ctacctaaat
     2701 tatagacttg tggtagtaaa aataataatg ctccaagtga agatttaaaa taaaaagcaa
     2761 ttgaatagga taataccgtt agtagcgacc acgacagtga tcccaataat ataaaatacc
     2821 acacattctt attcagtaac aaagggttca acccctctct tcctaaacca aactgtgcac
     2881 ttacaataga taaatagatt gagacaaatg acacaacaaa aataaataca catgtaacaa
     2941 taaattttat tacaaagaat acaaccttat ttgaacataa tagcaagctg gtacgtaaag
     3001 aactattttt atattccata tttccaagaa ttgctcctaa aattataata gcaaacaagc
     3061 ccaatagtat tgcatcaaaa ccaatatact caattggagg tattggttct gctaaactac
     3121 tattagtttc gggtgttgca ttcaatccaa ctgttaaaat ttgtttggaa ctgatataag
     3181 acaataacgg ctgaagaata aaaacaattg gtaaaactat ttgggttgat ctgctataaa
     3241 aaattttata tagctctgac aaaatattat agctttttat actactcatc atagtcaccc
     3301 cctgttaaat gaaagaaaac atcttctaga ttatcaaatc cgttcattat attattaagt
     3361 gtacccgaag ctatgatgct tcctttatta ataaaaacaa ccttatcagt taccgcctct
     3421 acttctgaaa gtatatgtga tgataacaat actgtcttac cagcacttgc ttgttctcta
     3481 ataaaatttc taaaccatct aattccacta ggatctagac catttgtagg ttcatctaaa
     3541 atcaggtact gaggttttcc caacagcgct gttgcaatac ctaacctctg cccctctcct
     3601 aatgaaaggt ttcctatttt tgaatatctt ttatgttcaa tatcagtaat ggataatacc
     3661 tctgatattc tggataaatc tattccatta ctagcagcag caattttcaa atgttgaaaa
     3721 actgttcgat cattgggagc ccccacacca tcgaaagaag ctcctacagt taaaagagga
     3781 cgttcaaaat cacaatattt cttacctcct attaaagcag tgcctgaaga tggcctatcc
     3841 agacccaaaa gtattcgtaa cgtcgaactt tttccagcac cattcggtcc caaaaaggca
     3901 gtgacttccc cctcttcagc tgtaaaggat acattcttta atatatctcc atctttataa
     3961 gtttttgtta catctcttat ttcaatctta tttgtcataa tacgatactc ctatactaaa
     4021 aattgttctt tagccaactc tttatataat ggaacagatt ccaatagctc cacatgagtc
     4081 ccacttccta caagtcttcc gtgttccaaa acaaagattt catctgaatc taaaattgta
     4141 gataatctat gagcaaccat tattatggtt ctctcacctc tcatattttt gattgcttcc
     4201 ttcatcttct tctcactaag actatctaga ttcgaagtta actcatccag caagagtatc
     4261 tttgcatcag aaagtattgc tcttgccatt gccaatctct gtctttctcc tcctgataaa
     4321 ttgaaacctc cttcaccaat ttgactctca accccagatg cacctctttg aatcaaatgc
     4381 tctaaaccaa ctttttttaa agcgtcacaa cattcatcat atgttacatt agtattaccc
     4441 atttttagat tttctaaaat tgtaccagct actaatggtg agttttgctc aacataagaa
     4501 atattagaac gtaaagtctc gcgactcatt gttcggaaat cttgtccaaa tacctttata
     4561 ctaccactag taatatcata gaatctttcg atgagataaa gaagtgtgct tttccccgca
     4621 ccagacggac cgacaatact gacgtaatct ccactattta tttcgaaagt aatgtccttt
     4681 aatatataat tatcatccga ttgaatatcc tgaaatttgt aagaatcata tgaaaaagtt
     4741 acattcgcaa attcaattgc tttgcttcta tccgacttag tttctagatt taaaatgata
     4801 tcattatctt cttcttttgg aagatcaata atttcagtaa ttctacctaa agctcctaaa
     4861 gcttctgaaa tagttgtgac cgatgaaaat atttgtccta ctggtgaaat agcgatatac
     4921 attaatagca taaaagaagt tagacttgca atagacattt gcccagtaga aacacggtat
     4981 cctccgactc ccaaaataat tatcccacac aactgcaagc taaaatttga tatcggtgtc
     5041 attattgatt gcactcttgc aactccaatt cccaagtttt ttacttcttg tgcctcagat
     5101 aacattttag ataattctga attcgtttca tttgtcgatc gaattgttct aattcctacg
     5161 attagcctat ttaagtatgc tgtcattttc cccaaaccct gatgagcttt ataacttgct
     5221 gtttgaatca aactactcat caataaaata aataggaatg ataaagatat ggaaataatt
     5281 gtaattattg caagatatgt atcctttaga aataatgtaa atatcgcacc taaactcaag
     5341 aacaatccac tcgtcagagc aacggttgat tgaatgattc ccgctcttag cttacttgta
     5401 tcactgctaa atcgactaat taggtctcct gctgacagat cattatattt ataaatagga
     5461 agtttaagaa attgaataat taaatttttt cttgattgaa atactgcact ttctcccatt
     5521 aattgtaaga aataatattg caaactggaa ataatagttg tacccacggt aatagcaata
     5581 agcgtataca tagtggaatt attgaataaa tttactccct tttgagagat tactttagac
     5641 aaaagttctg gctgtaataa cgttaaaatg gacgtaagta ttcccaaaca taaaacgatt
     5701 aaaaaatatt ttcctttatt ttctatcaag gcaagtaaat cacggaattt tacattagtc
     5761 atagtatcat ttactttttc tatatcttca gttatcatat gtttacgctc ttcattttta
     5821 tcatctagag ttttcacaac tctttcatac gatgatactt cttctagctc tttaatcgga
     5881 tttccattga cttccaccca tgcatgagat ctaaaggggt tcatagcaaa tccagtacac
     5941 caacttgcac gtttctttaa aagaagtaag aacattatta ctcctaatga tatttttacg
     6001 catccatctt gattcctaca cttacggctt acagtacata ttgcatcacg agctaataca
     6061 acttcattta ctgtggcgga taattttgag tcacttaatt tattaatcaa aaattcaatt
     6121 cttgtaggcg agagctttgt aagcggataa gagattagta aagctatttg cgctagtaat
     6181 ctgtacttta gctgaacata ggagtatgac tcttgattga gctgcatatc cataatctat
     6241 atccctcctt tttttagaga ctgtataaaa tctttaacat cttgttttgc aacatcggtt
     6301 tcaatggaat acgcagcaga tatagcacta actatttcct cttcattttt atttttagat
     6361 agtaattcta aaattttaac ccctacatca tttgtttgaa agtatatccc ttgatctttg
     6421 tcaaatacaa ttgcaccatt gtcctgcttt attattttta atcttgtttt agatccttta
     6481 ttaaacatag ttacaaacct cactcattct tcatatacaa tttaatctgc ctaatccaac
     6541 gttctaccga acataatctt tcaaaataat caattttatt cggatttccc gcaggtaatg
     6601 acagctctaa ttttaacttt tcaacatcaa caattcccat ttttaccact tcaaattgtt
     6661 ctaacttgtg gaagttttta cgaactgctt ctctatatcc actatataag gcatctgaat
     6721 aatcgccttt aaaacccctg ttgaaaactt caattggtac gatccccttc aatgcttttt
     6781 gcaataccgg ttttgttagc tttgaactaa ctttatattt tgctggaatt tgaagacaaa
     6841 tttctactaa ttttttatgt aaaaatggtg ttgcccaata aatggaatta gtagttaatt
     6901 gaatttgtcg caacactgat ttttgaaata ttaaagattg aatcatttgg aatgttgttc
     6961 tatcagtgat tattggctca gaattggaaa ataataacga gtttaaaaaa ctttgcgatt
     7021 cttttttgga tttttcactg agccaacttg gtacctgtag tccatccatc caccccagtt
     7081 ctcttttgat aggttcagaa gattcgttga agacaatttc taaattttgg gtcatggttt
     7141 ccaaatatcc tctcttatct aacaaatcca ataggcaact aaaaaatggt cttctcatta
     7201 tcaaactata tttcagagca taaagtagtc cacctaaatt ttcctgacgg actatactcc
     7261 agggattaga aggcatcggt gtgaataatt catcaccacc aatacctagg aaatgagtcg
     7321 gatgtttttt accttcctga taagtaatca ctgattttaa atatccttct gaatcggccc
     7381 acagtaatgg aaagcttgga ataataccat tgatatatcc ttcttctatt gcaaatcttt
     7441 tctctgttat ttctatagag tcaaattttt ttaactccct accaagattt tttgcaataa
     7501 atgtcgccca tttagtatca ctattggcag tagcacttga ttcagcatgc aaaatagaga
     7561 agtccggtat cattttattc aatgtaaaag caattgtcgc agaatcaaca cctcctgata
     7621 catcacttga cacttcattt cccatattta gatcatgatt aatgctattt aaaaactctt
     7681 cttttatttt aattattagt tgattaaaat ctttagtgtc tacttcataa cttggaatct
     7741 ttttttctaa acaacctttt tcggttattt ctaaatagtt taaaggtttt atatttacta
     7801 gctcttccca gaggctaatt gtttgaaatg gataatatgg aagtccaaaa acaaattgac
     7861 tcgctaaacg cttcgtggaa agttttaatt tcagatattt tgcaatctct acagaggaat
     7921 cgctaaaaat tatattttta ctattctcaa accaagacag tcttgaatct aagtaaggag
     7981 aaataacata agttctttca gccatttcaa taataattaa accatttata acacaatcct
     8041 ggagtaatga tattgtttct tcaaaactac tgatatcatt ctgttctata attgagcata
     8101 tttcttcaac atagtcttcc aaacaataga tttttgtatt atttacagaa acggttctat
     8161 ataaattttt agtaaggaat attatttttt tatcagaata tttttcaaaa aaatacttat
     8221 ttagcatgta tattaacaac ctcaaaaata aaaaacaaag catctcgata ttcgtagttc
     8281 tggaatgaat atcgaaacac tttattaaaa attatttact gttgtaatac atagttctaa
     8341 gcttagaact caattgtaac tcttacaatt gcacgtccac caaagacatc acgaaactta
     8401 ccagtccata gacctttagt gtcttttttg aaagttgcaa ttgattcaaa tgttggtttg
     8461 caatatttca ttttaaactc cttctatcat ttagactaat gccagaaccc attggtgtaa
     8521 atgaaaaata attttcaaga gttacctctt gattcaatta aattctacaa tatgaatttc
     8581 ggaaaaatat cagaaaatag atgaaggttg aacatatttc aaatatttct tgttttcact
     8641 ccgtggatta cttggtttcc ataataattt atatatcaac ttaatgaata tatctgggta
     8701 atggattata ttctaattaa aaataaagcc ctgccaccaa atatatctct gaagctacct
     8761 gcaactaatc ctgctgtacc atttttaaaa gtagaaattt tttctataac tggcttcgta
     8821 taattcat
//
