LOCUS       BGC0002576              3141 bp    DNA     linear   BCT 29-SEP-2021
DEFINITION  Thermoactinomyces sp. strain YM3-251 McmL gene, complete cds.
ACCESSION   BGC0002576
VERSION     BGC0002576
KEYWORDS    .
SOURCE      Thermoactinomyces sp
  ORGANISM  Thermoactinomyces sp.
            Bacteria; Firmicutes; Bacilli; Bacillales; Thermoactinomycetaceae;
            Thermoactinomyces; unclassified Thermoactinomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 10:46:31
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 3141
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..3141
                     /country="Palau: Mecherchar"
                     /culture_collection="DSMZ:DSM44894"
                     /db_xref="taxon:2025"
                     /isolation_source="sea mud"
                     /mol_type="genomic DNA"
                     /organism="Thermoactinomyces sp."
                     /strain="YM3-251"
     subregion       1..3141
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="RiPP"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..3141
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             1..3141
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     895.5; E-value: 6.4e-271)"
                     /gene_kind="biosynthetic"
                     /note="involved in biosynthesis of mechercharmycin A and
                     mechercharmycin B"
                     /product="McmL"
                     /protein_id="UBK24780.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.4e-178,
                     bitscore: 579.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-43, bitscore:
                     135.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 5.1e-14,
                     bitscore: 39.1, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADKQGEGLFEPLPQIMIRMPLHSIDEYQQISGEESLFNHLPTLV
                     KDPLVGEALYVANPPLYARMQRMDQKNLSPKKRKHILHSLARYALRMSSRPTPFGLFAG
                     MATGKLTEKTEWMVEERAKHRKQARIDMGWLLQWIEELERRREVVKQLTLKTNPTITLS
                     RAKYYVAVTTFNRGQEKEQDNRTYLRATKELETTFALAKQGLPFPLLLEELQVSFPQAP
                     DAKIESFIHKLIEEEFLLTSLRPVLSQTDPLPLLWRQLKSLVGVEEEVESLAKITDGLS
                     NYHQQFIGNDPLSLQPVERAANSLFPVNRLPLHVDLKLTMKEFALHRRVGEEVAAAAEC
                     LWRLGVLDRGKPHLHAYHQEFIEKYGTDCEVPVLELLDEHIGLGAPAGYHFPKSHRKEG
                     RKGKISERRDSLLRDLVLTAVRRGDPEIVIDDSIIEELAACSPHMETAPHSMELIAEVL
                     ASSPQAIDAGEYLLILSPHMGTLAAGQTFGRFFHLCEPEVQASFVELNREEEESNPHRC
                     YTELRYLPENGRYANVFLCPPVRKRELALNSSTSCVSNEVPLEEIVVGATSERLYLKLK
                     EKEQEVILDVPHSINLATTPNLFRFLSEVSRQQTRDFLPLSLGSIDKWPYLPRLRYRRT
                     ILRPARWRLSQSLWEEGISLGEWKAQLANWQQEWSVPRYVYLGEEDQRLLLDLTCDDHL
                     QLLQEELVKRDSVILTEMIGTLQERGVQDPSGQRYMTECVFPLKKKKSATRMASLPPFT
                     GFFRSLSSEEDRVKVPGSEWLYFKLYLPPAEENLFLLHSLTPFMKELARGGWIQDWYFL
                     RYKDPDDHLRVRCTGDPLILAQEVIPRLHKWVTPLVEKREVTRIVLDTYSREIERYGGR
                     ELIAAAERVFAVDSQVVAYLLQWERENRSFYPLEVMAAMSTFTLMEQYGLKLSACMQWF
                     ERFRGKEKYQSSYRKWKDHLIGWYFPQKQVGQKEKEQLLSLFERRREKVGDYATQWQHH
                     YQRPLTDSRNLKVLASFTHMHCNRLLGTGRQREEEAMALVAHTMVSVKHLQAKEKKV"
ORIGIN
        1 atggcggaca agcagggtga agggctattt gaaccgttgc ctcaaatcat gatccgcatg
       61 cctttgcact cgatcgatga gtatcaacaa atatctggcg aagaatccct ctttaatcac
      121 ttaccaacgc tagtgaaaga tcctcttgtg ggagaagcgt tgtatgtagc caacccccct
      181 ctctatgcac gcatgcaacg catggaccag aagaacctct caccaaagaa gagaaagcat
      241 attcttcata gtctggcccg ctatgcccta cggatgtcat cacgccccac cccttttgga
      301 ttatttgctg gtatggcgac gggcaaactt acggaaaaaa cggagtggat ggtagaggag
      361 agggctaagc atcgtaagca agcacgaata gatatggggt ggcttcttca gtggatagaa
      421 gagttagaga gaagacgtga agtggtaaaa caattaacgt taaaaaccaa tccaacgatt
      481 acactttcaa gagcaaaata ctatgttgct gttacaacat ttaatagggg acaggaaaaa
      541 gagcaagata atagaaccta cttgcgtgcg acaaaagagt tggaaaccac ttttgcctta
      601 gcgaaacaag gtcttccctt tccactattg ttggaagagt tacaagtttc ttttccgcag
      661 gctcctgatg cgaagattga atcgtttata cataaattga ttgaagaaga atttctgctg
      721 acctcgttac gaccggtcct ttcccaaacg gacccactgc ctctcttgtg gcgccaattg
      781 aaatcgcttg tgggggtgga agaggaggta gaatctctag ccaaaataac cgatggattg
      841 tccaactatc atcagcagtt tataggaaac gatcctttgt ctttgcaacc agtagagcgt
      901 gcggcaaatt ccctcttccc cgttaatcgc cttcctctac atgtggattt aaaactaaca
      961 atgaaggagt ttgccctgca tagacgagtg ggtgaagaag tggcagctgc agcggaatgt
     1021 ttatggcgtt tgggagtatt ggatagaggg aaaccgcatc tgcatgcgta tcatcaagaa
     1081 tttatagaaa aatatgggac ggactgcgaa gttccggtat tggaactgct cgatgagcat
     1141 attggattag gggcacctgc tggctatcat tttcctaaaa gtcaccgtaa ggaaggaagg
     1201 aaagggaaga tttcggagcg gcgggatagc ttactccgtg atctcgtact aacggcggtt
     1261 cgccgaggag atccggaaat cgtgatcgat gattcaatca tagaggagtt ggcagcgtgt
     1321 tctccccata tggagacagc tccgcattcg atggagctga tcgccgaagt gcttgcttct
     1381 tctccgcaag cgattgacgc tggggaatac ttgcttatct taagtcccca tatgggcacg
     1441 ctagcagccg gccaaacgtt tgggcggttt tttcatctat gtgaaccgga ggtgcaagct
     1501 tcttttgtgg agttgaatcg ggaagaagaa gagagcaacc cccatcgttg ttatactgag
     1561 ctccgttatt taccggaaaa cgggcgttat gcgaatgtct ttttgtgtcc accagtacga
     1621 aaaagggaac tcgcgctcaa tagctcaact tcttgcgtga gcaacgaagt ccccttagaa
     1681 gaaattgtcg ttggagccac atctgagcgc ctttatctta aattaaaaga gaaggaacaa
     1741 gaggtgattt tggatgttcc gcactccatc aacctagcca cgacacctaa tctcttccgc
     1801 tttctgagcg aggtatcccg acaacagaca agagactttc ttcccttatc gctaggaagt
     1861 atagacaaat ggccttacct gcctcggctt cgatatcggc gcacgatctt gcgtcctgct
     1921 cgttggcggt taagtcaatc gctgtgggaa gaagggattt cgctaggtga atggaaagcg
     1981 caattggcaa actggcaaca ggagtggtct gttccgcgtt acgtctatct gggagaagag
     2041 gatcaacgtt tgctgttaga tttgacgtgt gatgatcatc tccaactcct acaagaagaa
     2101 ctggtgaaaa gggatagcgt tattctaaca gagatgatag ggacgttgca ggaaagaggg
     2161 gtgcaagatc cctctggtca aaggtacatg acagagtgtg tttttcctct gaaaaagaaa
     2221 aagagtgcaa cccgaatggc atctcttcct ccattcacgg gattctttcg ctccctttct
     2281 tcagaggaag accgagtaaa agttccagga agtgagtggc tttattttaa actgtatttg
     2341 ccacctgccg aggagaatct ttttcttctt cattccctca ctccatttat gaaggagtta
     2401 gcaagaggtg gttggataca agattggtac ttcctgcgtt acaaagaccc cgatgatcat
     2461 ttgcgtgtgc gctgtacggg ggatccgttg atattggcac aagaggtgat cccgcgcttg
     2521 cacaaatggg ttactcctct tgtggaaaag cgagaggtta ctcgcatcgt gttggatact
     2581 tattcgagag agattgagcg gtatggtggc cgtgagttga tagccgcagc agagagagtg
     2641 tttgcggtgg atagtcaggt agttgcctac ttattgcaat gggaacggga gaatcgctcg
     2701 ttctaccctc tagaagtgat ggccgctatg agcacgttta ctttgatgga acaatacggg
     2761 ttgaagttat cagcatgtat gcagtggttt gaacgttttc gtgggaaaga aaagtaccaa
     2821 tcttcttacc ggaagtggaa agatcatttg ataggatggt acttcccgca gaagcaggta
     2881 ggccaaaaag aaaaggagca acttctctct ctttttgaac ggagaagaga aaaggtaggg
     2941 gactatgcga cacaatggca acatcactat caacgtcctc tgaccgatag ccggaactta
     3001 aaagtattgg ctagctttac acatatgcat tgcaatcgtt tattgggaac aggccgtcag
     3061 cgagaggaag aagcgatggc attggttgcc catacgatgg taagtgtgaa acatctgcag
     3121 gcaaaagaga aaaaagttta g
//
