LOCUS       BGC0002578             10145 bp    DNA     linear   BCT 27-FEB-2015
DEFINITION  Streptomyces venezuelae ATCC 10712 complete genome.
ACCESSION   BGC0002578
VERSION     BGC0002578
KEYWORDS    .
SOURCE      Streptomyces venezuelae ATCC 10712
  ORGANISM  Streptomyces venezuelae ATCC 10712
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 18:02:19
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 4521430
            Orig. end    :: 4531575
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1677
                     /EC_number="4.1.1.19"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:SVEN_4179"
                     /db_xref="EnsemblGenomes-Tr:CCA57465"
                     /db_xref="GOA:F2RHD7"
                     /db_xref="InterPro:IPR000310"
                     /db_xref="InterPro:IPR008286"
                     /db_xref="InterPro:IPR015421"
                     /db_xref="InterPro:IPR015424"
                     /db_xref="UniProtKB/TrEMBL:F2RHD7"
                     /locus_tag="SVEN_4179"
                     /old_locus_tag="SMD06440"
                     /product="Arginine decarboxylase"
                     /protein_id="CCA57465.1"
                     /transl_table=11
                     /translation="MTASTSSTPEPAHRPARPGAYPDGRTPLADAVLAVARRDIATFHA
                     LPLSHGRSIRDSHMRETYEALFGAAQLAADVSYSGTMLDSFFRPRGPLREAQRLAARSF
                     GADATFFLSAGTSTANRVALTAMTRPGSRVLADRSCHQSVHFALNSLGVSVAYAPMQRC
                     CEDCPRTYADLPRLLEMFRAAAVEGRPYDTVVLSAVSYDGVRYDLPTVLAELAAVHPGV
                     AVLVDEAWGAAHRFHPRLRPLTALHAVETLRAADPRFTMNVAVTHSAHKSMSALRQGSY
                     LHLIGDGEARERTAQALFQHHTTSPSWPVLASLDLARLQAETEGEALLGRSLGLARTLR
                     VELATDPRLSAYRPLGPDGHLTDPAQLVSDDPTRVLVDISALGITAADFRRMLFDEYAL
                     YVARESGDAVLFHIHIGVDEATLLRLLDALRTIQRTYRSASEALAAGTSEHFIIAYPPG
                     IPITVPGEKLCERTLSQIDTLRSSGCEIYTLRNPTVSAGALAAQAAATGALPVPAGHLA
                     APPPTSERLAGAAAAVSAAGTTAATVSAAAATAVATAVATS"
     subregion       1..10145
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10145
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..1677
                     /locus_tag="SVEN_4179"
                     /old_locus_tag="SMD06440"
     gene            1963..3561
                     /locus_tag="SVEN_4180"
                     /old_locus_tag="SMD06441"
     CDS             1963..3561
                     /NRPS_PKS="Domain: AMP-binding (7-415). E-value: 5.3e-60.
                     Score: 194.9. Matches aSDomain:
                     nrpspksdomains_SVEN_4180_AMP-binding.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:SVEN_4180"
                     /db_xref="EnsemblGenomes-Tr:CCA57466"
                     /db_xref="GOA:F2RHD8"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="UniProtKB/TrEMBL:F2RHD8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     198.2; E-value: 3.2e-60)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SVEN_4180"
                     /old_locus_tag="SMD06441"
                     /product="hypothetical protein"
                     /protein_id="CCA57466.1"
                     /sec_met_domain="AMP-binding (E-value: 2.1e-57, bitscore:
                     183.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKIADIRKHATRWPQRVAVVDGETRMTWASFSDKVSRVSCAIQD
                     LLPETRPARAVFLAENSWELVVSMAAVSSLGIPCVGLDYTAGPVATRAALDQLEPTVVI
                     TSRAHRALLEECGWPNGRDILDIFLDSEPVGLPDGQTVSVSFTDLLVSAPGDPQPVEQP
                     FEAFSFTSGTSGVPKMVVRRTSFEARRFADLVDQYAFDEEDVHLVTVPLYHASGPGWAR
                     IFLTLGGTVVLGPHDDAGELIRIIQDEGVSTTLMVPPVLARVVAHPDSEHLHKTSRLHF
                     VLSGGRHLNRWVINNAWDRLGPVLHLYYGTTETGVNVMIGPEELHVAPCRSGRPMPGNT
                     VVVLDAENRPLPKGSRGRVAIASYQLMDSYATSEPDFMTLDYGGRTQRFLLTGDSGLVD
                     EAGRLELTGRNDGVAKAEAGKPLDVNIFGLEADLMDLPCVRETAVLRTSLPGAGEVLVV
                     PFTPVAPERQESGYRAVSAACARRVPCLPAYVVPVDAIPYSPTGKVRAAQLLESVLPLL
                     DIRPADEREAETVGV"
     aSDomain        1984..3207
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SVEN_4180_AMP-binding.1"
                     /evalue="5.30E-60"
                     /label="SVEN_4180_AMP-binding.1"
                     /locus_tag="SVEN_4180"
                     /protein_end="415"
                     /protein_start="7"
                     /score="194.9"
                     /tool="antismash"
                     /translation="RKHATRWPQRVAVVDGETRMTWASFSDKVSRVSCAIQDLLPETRP
                     ARAVFLAENSWELVVSMAAVSSLGIPCVGLDYTAGPVATRAALDQLEPTVVITSRAHRA
                     LLEECGWPNGRDILDIFLDSEPVGLPDGQTVSVSFTDLLVSAPGDPQPVEQPFEAFSFT
                     SGTSGVPKMVVRRTSFEARRFADLVDQYAFDEEDVHLVTVPLYHASGPGWARIFLTLGG
                     TVVLGPHDDAGELIRIIQDEGVSTTLMVPPVLARVVAHPDSEHLHKTSRLHFVLSGGRH
                     LNRWVINNAWDRLGPVLHLYYGTTETGVNVMIGPEELHVAPCRSGRPMPGNTVVVLDAE
                     NRPLPKGSRGRVAIASYQLMDSYATSEPDFMTLDYGGRTQRFLLTGDSGLVDEAGRLEL
                     TGRNDGVAK"
     CDS_motif       2467..2505
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SVEN_4180_0001"
                     /evalue="2.30E-03"
                     /label="NRPS-A_a3"
                     /locus_tag="SVEN_4180"
                     /protein_end="181"
                     /protein_start="168"
                     /score="11.1"
                     /tool="antismash"
                     /translation="FTSGTSGVPKMVV"
     gene            3799..4863
                     /locus_tag="SVEN_4181"
                     /old_locus_tag="SMD06442"
     CDS             3799..4863
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:SVEN_4181"
                     /db_xref="EnsemblGenomes-Tr:CCA57467"
                     /db_xref="GOA:F2RHD9"
                     /db_xref="InterPro:IPR000620"
                     /db_xref="UniProtKB/TrEMBL:F2RHD9"
                     /gene_functions="transport (smcogs) SMCOG1166:transporter,
                     EamA family (Score: 84.6; E-value: 1.3e-25)"
                     /gene_kind="transport"
                     /locus_tag="SVEN_4181"
                     /old_locus_tag="SMD06442"
                     /product="hypothetical protein"
                     /protein_id="CCA57467.1"
                     /transl_table=11
                     /translation="MNSQNTYTRGVLLCLLATVSWGAMFPLMDSTLQHIDPFTFTVMRY
                     TIAGAMFLVFLRMREGREGLRLKGERIGLAWLFGTAGFAGFQFLVFFGQDLIGARGALN
                     ASIMMATMPMMGFLVNWVMKKVVPPKFSLVFIAMSFVGTILVVSNGDIGSLIASPKEAG
                     ADALLLFAALCWVVYTSGASYFPTWSPIKYTAITTVLGLASATVITAVILAAGGVPVPT
                     AGAVGTILPQLAYMSVIAGFVGVLGWNFGNRYLGPLNGVLFMDVVPVTAFVISALTGVV
                     PAGVQIVGASLTAAALVFNNLYLRRIAKAAPAASPAPAASGPSVGSSSGTSSGTASGSG
                     SASAPAPVGSGTRS"
     gene            complement(4980..5582)
                     /locus_tag="SVEN_4182"
                     /old_locus_tag="SMD06443"
     CDS             complement(4980..5582)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:SVEN_4182"
                     /db_xref="EnsemblGenomes-Tr:CCA57468"
                     /db_xref="GOA:F2RHE0"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR011075"
                     /db_xref="InterPro:IPR015893"
                     /db_xref="UniProtKB/TrEMBL:F2RHE0"
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 100.2; E-value: 3.3e-30)"
                     /gene_kind="regulatory"
                     /locus_tag="SVEN_4182"
                     /old_locus_tag="SMD06443"
                     /product="TetR-family transcriptional regulator"
                     /protein_id="CCA57468.1"
                     /transl_table=11
                     /translation="MATPRSQPKQERARRTKVHILQSAAELFAERGYATVTLQDVAERA
                     EMTKGAVYFHYTNKEALAVAVVQEHYARWPEILKGAEGDHAEPFDMLTAVLDTVTRAFA
                     RDIVVQAGARLQIERALIDAELPEPYVGWEDYLTRLIAEARDAGQLRDGVEPRAAARVL
                     VSAFFGMQHISDVLSGRSDLTERYEELRTVLLEGLRR"
     gene            5704..6741
                     /locus_tag="SVEN_4183"
                     /old_locus_tag="SMD06446"
     CDS             5704..6741
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:SVEN_4183"
                     /db_xref="EnsemblGenomes-Tr:CCA57469"
                     /db_xref="InterPro:IPR005509"
                     /db_xref="UniProtKB/TrEMBL:F2RHE1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /locus_tag="SVEN_4183"
                     /old_locus_tag="SMD06446"
                     /product="A-factor biosynthesis protein AfsA"
                     /protein_id="CCA57469.1"
                     /sec_met_domain="AfsA (E-value: 8.2e-26, bitscore: 79.5,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIGVLQTVLPLEPLEPLESLESLVREAKDGLSFDRTISRRLVHR
                     ASVTEVFLTDAAVAGADRFLIGAQLPRNHALYRPEETGQCDFMLLVETVRQAGIYLSHR
                     HYDVPLGHHFIFKALSLHISDPAALRVGAGPLAVVLDVNVATPGGRTAGIPGARNPRRF
                     DARFDMVIEVGGRECARASAGVTVIDGVRYARLRQRGRTEGTVSARPSAYEGTAPARPS
                     AYERKGGAPGDGRGVLRPAPGTAIRPAGTGEWRLHVDPTHPGYFEHPSDHVPGMLLLEA
                     FRQAALELCGGTVLASLEAEFAVFGELGEAVTVQAAATTAGDGRMRLSATQGGRVLATA
                     GARRA"
     gene            6820..7116
                     /locus_tag="SVEN_4184"
                     /old_locus_tag="SMD06447"
     CDS             6820..7116
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:SVEN_4184"
                     /db_xref="EnsemblGenomes-Tr:CCA57470"
                     /db_xref="GOA:F2RHE2"
                     /db_xref="InterPro:IPR000847"
                     /db_xref="InterPro:IPR011991"
                     /db_xref="UniProtKB/TrEMBL:F2RHE2"
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 97.4; E-value: 1.4e-29)"
                     /gene_kind="regulatory"
                     /locus_tag="SVEN_4184"
                     /old_locus_tag="SMD06447"
                     /product="LysR family transcriptional regulator YnfL"
                     /protein_id="CCA57470.1"
                     /transl_table=11
                     /translation="MELQHLRAFREVARELSFTRAAHNLHYSQPAVTAQIKGLEEDMGA
                     SLFQRRGNRSVELTPAGARLRPLAEQILELVDTAQHEIAGPVGAGGRARGGRA"
     gene            7113..7886
                     /locus_tag="SVEN_4185"
                     /old_locus_tag="SMD06448"
     CDS             7113..7886
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:SVEN_4185"
                     /db_xref="EnsemblGenomes-Tr:CCA57471"
                     /db_xref="GOA:F2RHE3"
                     /db_xref="InterPro:IPR006383"
                     /db_xref="InterPro:IPR006385"
                     /db_xref="InterPro:IPR023214"
                     /db_xref="UniProtKB/TrEMBL:F2RHE3"
                     /locus_tag="SVEN_4185"
                     /old_locus_tag="SMD06448"
                     /product="HAD-superfamily subfamily IB, PSPase"
                     /protein_id="CCA57471.1"
                     /transl_table=11
                     /translation="MSIAPGRAAFFDVDETLITCKSMACVLARFWGRGEVAARRFAAAH
                     AELRRMIREGVPREQVNRTFFRFLAGSHLDDLETCGQEWYEKARTGGLLHTPVYEALRR
                     HAGAGDLVVLVSGAFSACLEPLARDIGADLVVCTVPEVTSEGVLTGELVGPPMLGEAKG
                     EAARRIMTAFGLGPEECFAYADDESDLPLLRSVGHPVLVGDGPVSAPPSETAGWSWLPG
                     PAPAAAPSAPAPAPGRPSAARTAAATARRPVTQAA"
     gene            complement(7893..8120)
                     /locus_tag="SVEN_4186"
                     /old_locus_tag="SMD06448.3"
     CDS             complement(7893..8120)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:SVEN_4186"
                     /db_xref="EnsemblGenomes-Tr:CCA57472"
                     /db_xref="UniProtKB/TrEMBL:F2RHE4"
                     /locus_tag="SVEN_4186"
                     /old_locus_tag="SMD06448.3"
                     /product="hypothetical protein"
                     /protein_id="CCA57472.1"
                     /transl_table=11
                     /translation="MAAGLPRRVVVFQALSDDECDVGEEGLARDVGDVGNEPSGVRGGT
                     GEDSHAREGEDKSGTLPSGPRQILRPSAAS"
     gene            complement(8173..8793)
                     /locus_tag="SVEN_4187"
                     /old_locus_tag="SMD06449"
     CDS             complement(8173..8793)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:SVEN_4187"
                     /db_xref="EnsemblGenomes-Tr:CCA57473"
                     /db_xref="GOA:F2RHE5"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR011075"
                     /db_xref="InterPro:IPR015893"
                     /db_xref="UniProtKB/TrEMBL:F2RHE5"
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 71.5; E-value: 2e-21)"
                     /gene_kind="regulatory"
                     /locus_tag="SVEN_4187"
                     /old_locus_tag="SMD06449"
                     /product="TetR-family transcriptional regulator"
                     /protein_id="CCA57473.1"
                     /transl_table=11
                     /translation="MKQQDRARMTYDLVLGAAAAEFALHGFAGTNLADITARTGLTKGA
                     LYGHFSSKADLAGELTRSFESRWADALATAATRGAGATAQRGTALTALRGLLVELSRRV
                     YEDLPFAAGLRLVMDAARAEGTVPVQLGELCGVVELLIRRGQEEGSVSDAHPAGLLAQL
                     AVALLVGAPAVVRATDTTGPADLVREVWDVLEPSLSTARPATA"
     gene            8928..10145
                     /locus_tag="SVEN_4188"
                     /old_locus_tag="SMD06451"
     CDS             8928..10145
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:SVEN_4188"
                     /db_xref="EnsemblGenomes-Tr:CCA57474"
                     /db_xref="GOA:F2RHE6"
                     /db_xref="InterPro:IPR006091"
                     /db_xref="InterPro:IPR009075"
                     /db_xref="InterPro:IPR009100"
                     /db_xref="InterPro:IPR013107"
                     /db_xref="InterPro:IPR013786"
                     /db_xref="UniProtKB/TrEMBL:F2RHE6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191:acyl-CoA dehydrogenase type 2 (Score: 330.9;
                     E-value: 1.4e-100)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SVEN_4188"
                     /old_locus_tag="SMD06451"
                     /product="hypothetical protein"
                     /protein_id="CCA57474.1"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3.7e-10, bitscore:
                     29.6, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVVDTPASLATGYLYAAAARHAEGSERSGRLHPEVVTAMTAAGL
                     ARHFVPRRWGGRAGGFAELLDTVAEVGTACASTAWCGALLAAHGRLAAHLPVEGQRELW
                     GDSPDTRVAAAVVPPAGRLRRVPGGWRLSGEWAFASGVEDAEWVLLASLDHSGAGAPGY
                     RVLAVPRERVGIRETWDAVGLRATGSHSVVIEEAAEVFVPEHRTFLRETLVTGVVTGAV
                     DPGEGAAGSEAGDAPAEVAPCHRVPYQLVASLQFAAPALGAARGALEAWTLMTGLRRLP
                     DGRPLTEDPVVQQTLSRSAAEIDAAHLLLKAAATRADDWPGGAAGARDAREAVTALNQR
                     DAAGAVDLLVGAVERLMRAGGARGLIAGGGLERAWRDVHAIAAHAALQPAPAAAAYAAT
                     VFPTSP"
ORIGIN
        1 atgaccgcat ccaccagctc cactccggag ccggcccatc ggccggctcg ccccggggcc
       61 tacccggacg gcaggacacc cctcgctgac gccgtgctcg cagtcgcccg acgtgacatc
      121 gccacgttcc acgcgctgcc gctctcgcac ggccggtcta tccgcgactc ccacatgcgg
      181 gagacctacg aggcgctctt cggcgccgcg cagctcgcgg ccgacgtgtc gtacagcggc
      241 acgatgctcg actccttctt ccggccccga ggcccgctcc gcgaggccca gcggctcgcc
      301 gcccgcagct tcggcgccga cgccacgttc ttcctgtcgg ccggcaccag caccgccaac
      361 cgggtcgccc tcaccgccat gacccggccc ggctcccggg tgctcgccga ccgctcctgc
      421 caccagtcgg tgcacttcgc gctcaactcc ctcggcgtct ccgtcgccta cgcgccgatg
      481 cagcgctgct gcgaggactg cccacggacg tacgccgacc tgccccggct cctggagatg
      541 ttccgcgccg ccgccgtcga aggccggccc tacgacaccg tcgtcctctc cgccgtctcc
      601 tacgacggtg tccgctacga cctgccgacc gtcctcgccg aactcgccgc cgtccacccg
      661 ggcgtcgccg tcctcgtcga cgaggcctgg ggcgccgcgc accgcttcca cccccggctg
      721 cgcccgctca ccgcgctgca cgccgtcgag acgctgcgcg ccgccgatcc ccggttcacc
      781 atgaacgtgg ccgtcaccca ctccgcccac aagtcgatgt cggcgctccg gcaaggctcg
      841 tacctgcacc tcatcggcga cggcgaagcc cgcgaacgca ccgcgcaggc cctcttccag
      901 caccacacca cctcacccag ctggccggtg ctcgccagcc tcgacctcgc caggctccag
      961 gccgagaccg agggcgaggc gctcctcggg cgttccctcg ggctcgcccg caccctgcgc
     1021 gtcgaactcg ccaccgaccc gaggctctcg gcgtaccgcc cgctcgggcc cgacggccac
     1081 ctcaccgacc cggcgcagct ggtcagcgac gatcccaccc gggtcctcgt cgacatcagc
     1141 gccctcggca tcacggcggc ggacttccgc cggatgctct tcgacgagta cgcgctgtac
     1201 gtggcccggg agagcggtga cgccgtcctc ttccacatcc acatcggggt ggacgaggcg
     1261 acgctgctac ggctcctcga cgcgctgcgc acgatccagc gcacgtaccg gagcgcctcc
     1321 gaggccctgg cggcggggac ctccgagcac ttcatcatcg cgtacccgcc cggcatcccc
     1381 atcacggtgc ccggcgagaa gctctgcgag cggacgctca gtcagatcga cacgctccgt
     1441 tccagcggct gcgagatcta caccttgcgg aacccgaccg tctcggccgg tgcgctcgcc
     1501 gcgcaggcgg cggcgacggg ggccctgccg gtccccgccg gccacctcgc cgcgccgccg
     1561 cccacctcgg agcggctcgc gggcgcggcc gccgcggtct cggcggcggg cacgaccgcc
     1621 gcgacggtct cggccgccgc ggccacggcc gtcgccaccg cggtggccac cagctgacca
     1681 cacctcacct cccggctcca cccccggcgc aggcgtcggc tcgaccccga gtcccgcgcc
     1741 agttccaccg gctccggcgc cagttccgcc cggctccacc cgcgctccga tgccggctcc
     1801 accccggctc ccgcgccagt tccacccggc tcggctgcgc tccaccccgg ctccacccgc
     1861 gctccggcgc ccgctccacc ccggcagcga tcccggcgcc ggtcgtcccc actccgccgc
     1921 gccactccgc ctccgatccc gacttcgagg gagaacacct ccatgatcaa gatcgcggac
     1981 atccgtaagc acgccacccg ctggccccag cgcgtcgccg tcgtcgacgg cgagacccgt
     2041 atgacctggg cgagcttctc cgacaaggtc agccgcgtgt cctgcgccat ccaggacttg
     2101 ctgcccgaga cccggcccgc ccgggccgtg ttcctcgccg agaacagctg ggagctggtc
     2161 gtctccatgg ccgccgtcag ctcgctcggc atcccctgcg tcgggctcga ctacaccgcc
     2221 ggccccgtcg ccacccgcgc ggcgctcgac cagctggaac cgaccgtcgt gatcacctcg
     2281 cgggcccacc gcgccctcct ggaggagtgc ggctggccga acggcagaga catactcgac
     2341 atattcctcg acagcgagcc cgtcggcctg cccgacggcc agaccgtctc ggtcagcttc
     2401 accgacctcc tcgtctcggc gcccggcgac ccccagccgg tcgagcagcc cttcgaggcc
     2461 ttctccttca cctccggcac cagcggcgtg cccaagatgg tcgtccgccg gacctccttc
     2521 gaggcccgcc gcttcgccga tctcgtcgac cagtacgcct tcgacgagga ggacgtccac
     2581 ctggtcaccg tgccgctcta ccacgcctcc gggcccggct gggcgcgcat cttcctcacc
     2641 ctgggcggca ccgtcgttct cggcccgcac gacgacgccg gggagctcat ccgcatcatc
     2701 caggacgagg gcgtctccac caccctcatg gtgccgcccg tcctcgcccg ggtcgtcgcc
     2761 caccccgact ccgagcacct gcacaagacg tcccggctgc acttcgtcct ctccggcggc
     2821 cggcacctca accgctgggt catcaacaac gcctgggacc gtctcggccc cgtcctccac
     2881 ctctactacg ggaccaccga gaccggcgtg aacgtcatga tcggacccga ggagctgcac
     2941 gtggctccct gccgttccgg ccgtcccatg cccggcaaca ccgtcgtcgt cctggacgcc
     3001 gagaaccgcc cgctccccaa gggcagccgc ggccgggtcg ccatagcgag ctaccagctg
     3061 atggacagtt acgcgaccag cgagcccgac ttcatgacgc tcgactacgg cggccgcacc
     3121 cagcggttcc tgctcaccgg cgacagcggg ctcgtcgacg aggcgggccg gctcgaactc
     3181 accggccgca acgacggcgt cgccaaggcc gaggcgggca agccgctcga cgtcaacatc
     3241 ttcgggctcg aagccgacct gatggacctg ccctgcgtcc gcgagacggc cgtcctgcgg
     3301 accagtctcc ccggcgccgg cgaggtgctc gtcgtgccct tcacgccggt cgcgcccgaa
     3361 cgccaggaga gcggctaccg ggcggtcagc gccgcctgcg cccgccgcgt gccctgcctc
     3421 ccggcgtacg tggtgcccgt cgacgccatc ccgtacagcc ccaccggcaa ggtccgggcg
     3481 gcccagctcc tggagtcggt cctcccgctc ctggacatcc ggccggcgga cgagcgcgag
     3541 gcggagacgg tcggggtctg acccggccgc ccccgccgac ccgtccgacc cgcagacccg
     3601 gccgacccgt ccgacccgcc gaccggccga ccccgccgac cggtggacct tgcccggtcg
     3661 tcgttcctgg cccccggccg gcggaccccc ttcccgccgg ccggccctcc ctcctcggat
     3721 tccccgcctc acccccgtag ccctacctcc ccttcccctc ctcaactccc agccggaaca
     3781 ggcctgacag gaagagtcat gaacagtcag aacacgtaca cgcgaggcgt ccttctctgc
     3841 ctcctggcca cggtgtcctg gggcgcgatg ttccccctca tggattccac cctccagcac
     3901 atcgacccgt tcaccttcac ggtcatgcgg tacaccatcg ccggcgcgat gttcctggtc
     3961 ttcctgcgga tgcgcgaggg gcgggagggg ctgcgcctga agggcgaacg catcggcctg
     4021 gcctggctgt tcggcaccgc cgggttcgcg ggcttccagt tcctggtctt cttcgggcag
     4081 gacctcatcg gcgcccgggg cgcgctcaac gcctcgatca tgatggcgac catgcccatg
     4141 atgggcttcc tggtgaactg ggtcatgaag aaggtcgtcc cgccgaagtt ctcgctcgtc
     4201 ttcatcgcga tgtccttcgt cggcaccatc ctggtcgtct ccaacggcga catcggctcc
     4261 ctgatcgcct ccccgaagga ggcgggcgcc gacgccctgc tgctcttcgc cgcgctgtgc
     4321 tgggtcgtct acacgtcggg tgcgagctac ttcccgacct ggtccccgat caagtacacg
     4381 gcgatcacga cggtcctcgg gctcgcgagc gccaccgtga tcacggcggt catcctggcg
     4441 gccggcgggg tgccggtccc gacggcgggt gccgtgggca cgatccttcc gcagctggcg
     4501 tacatgagcg tcatcgccgg cttcgtgggt gtgctcggct ggaacttcgg caaccgctac
     4561 ctcggcccgc tcaacggcgt cctgttcatg gacgtggtgc cggtgaccgc cttcgtgatc
     4621 tccgccctga cgggggtcgt cccggccggc gtgcagatcg tcggcgcctc gctcacggcg
     4681 gcggcgctgg tcttcaacaa cctgtacctg cggcgcatcg ccaaggccgc ccccgccgcg
     4741 tccccggcgc ccgccgcgtc cggaccgtcc gtcggctcgt cttccggtac gtcctccggt
     4801 acggcctccg gttcgggttc cgcttccgct cccgcgccgg tcgggtcggg caccaggtcc
     4861 tgacgccccg acccgtacgg cccgggtgcg cgtccccggg aacgcctatg gcgtggcctc
     4921 ccacacctcg tggggggcca cgcccgtttt ccggtcccgc gcggtggcct ggcggccgat
     4981 cagcggcgca ggccttcgag gaggacggtg cgcagctcct cgtaccgctc ggtgaggtcc
     5041 gagcggccgc tgaggacgtc ggagatgtgc tgcatgccga agaaggcgga gacgaggacg
     5101 cgggccgcgg cgcggggttc cactccgtcc cgcagttgtc ccgcgtcccg ggcttcggcg
     5161 atgaggcggg tgaggtagtc ctcccagccg acgtacggct ccgggagctc ggcgtcgatg
     5221 agggcgcgct cgatctggag ccgggcgccg gcctggacga cgatgtcccg cgcgaacgcc
     5281 cgggtgaccg tgtcgaggac ggcggtgagc atgtcgaacg gctccgcgtg gtcgccctcg
     5341 gcgcccttga ggatctcggg ccagcgggcg tagtgctcct ggacgaccgc gacggcgagg
     5401 gcctccttgt tcgtgtagtg gaagtacacc gcgcccttgg tcatctcggc gcgctcggcc
     5461 acgtcctgca gggtgacggt cgcgtagccg cgctccgcga agagctcggc cgccgactgg
     5521 aggatgtgca ccttcgtacg ccgggcgcgc tcctgcttcg gttggcttcg gggtgtcgcc
     5581 atgcctgtcc gcctctctcg ttcgtatgcc ttgcaatata cattctcgaa ggtatatttc
     5641 ttgctgccga ggggccgccg aggtccctcg tcgcaacgat gattcacctt gagggggaaa
     5701 aggatgtcca tcggtgtgct gcagaccgta ttgcctcttg agccgcttga gcccctggag
     5761 tcactggagt ctctcgtgcg ggaggccaag gacggcctca gcttcgaccg aacgatctcc
     5821 cgacggctcg tccaccgcgc ctcggtgacg gaggtcttcc tcaccgacgc ggccgtcgcc
     5881 ggcgcggacc gcttcctgat cggggcccaa ctgccccgca accacgccct gtaccgcccg
     5941 gaggagaccg ggcagtgcga cttcatgctc ctcgtcgaga ccgtgcggca ggccgggatc
     6001 tacctgagcc accggcacta cgacgtgccg ctcggccacc acttcatctt caaggccctg
     6061 tcgctgcaca tcagcgaccc ggccgcgctc cgggtcggcg ccggaccgct cgcggtggtc
     6121 ctcgacgtga acgtcgccac gccgggcgga cggacggccg gcatccccgg cgcgcgcaac
     6181 ccgcggcgct tcgacgcccg cttcgacatg gtgatcgagg tcggcggacg ggagtgcgcc
     6241 cgcgcctccg ccggggtgac cgtgatcgac ggggtgcggt acgcccgcct ccggcagcgg
     6301 ggccgtaccg aggggaccgt gtcggcccgc ccgtccgcgt acgagggaac cgcgcccgcc
     6361 cgcccgtccg cgtacgagag gaagggcggg gcccccggcg acggacgggg cgtgctgcgc
     6421 cccgcgccgg ggacggcgat acggccggcc ggcaccggcg agtggcggct gcacgtcgac
     6481 cccacgcacc ccgggtactt cgagcacccg tcggaccacg tccccgggat gctcctcctg
     6541 gaagccttcc ggcaggccgc cctcgaactc tgtggaggga ccgtactggc ctccctggaa
     6601 gccgagttcg cggtgttcgg ggagctgggc gaggcggtga ccgtccaagc ggcggcgacg
     6661 accgcggggg acggccggat gcggctgtcg gcgacccagg gaggtcgcgt gctcgcgacg
     6721 gcgggggccc gccgcgcgtg agggccggag gcgcgacccg aaggacgaac ggaccgacgt
     6781 agaggcgtag agacgtagag acgtagaaag gaaagagcga tggaactcca gcacttacgg
     6841 gccttccgcg aagtggcccg agaactcagc ttcacccgcg cggcgcacaa cctgcactac
     6901 tcccagcccg ccgtgaccgc gcagatcaag ggcctggaag aggacatggg ggcgtcgctg
     6961 ttccagcggc gcggcaaccg ctccgtggaa ctgacgccgg ccggggcgcg cctgcgtccg
     7021 ctggcggaac agatcctgga actggtcgac accgcccagc acgagatcgc gggcccggtc
     7081 ggcgccggcg gccgggccag agggggcaga gcatgagcat cgctcccggc cgcgccgcgt
     7141 tcttcgacgt cgacgagacc ctgatcacct gcaagagcat ggcctgcgtc ctcgcccgct
     7201 tctgggggcg cggcgaagtg gccgcccgca ggttcgccgc ggcgcacgcc gaactccggc
     7261 gcatgatccg cgagggcgtg ccccgcgagc aggtgaaccg aaccttcttc cgtttcctgg
     7321 ccggcagcca cctcgacgac ctggagacct gcggacagga gtggtacgag aaggcccgca
     7381 ccggcggact cctccacacc cccgtgtacg aggcgctccg acgccacgcc ggcgccggcg
     7441 acctcgtcgt cctcgtctcc ggagccttct ccgcctgcct ggagccgctg gcccgcgaca
     7501 tcggcgccga cctcgtcgtg tgcaccgtgc ccgaggtgac ctcggaggga gtgctcaccg
     7561 gggaactggt cggcccgccg atgctcggcg aggcgaaggg cgaggcggcc cgccggatca
     7621 tgacggcctt cgggctcggg cccgaggagt gtttcgcgta cgccgacgac gagagcgacc
     7681 tgccgctgct gcgctccgtc ggtcacccgg tcctcgtcgg cgacggaccg gtctccgcac
     7741 cgccctccga gacggcgggc tggtcctggc tcccgggccc cgcgcccgcc gcggcgcctt
     7801 cggccccggc gcccgctccg ggccggccct cggccgcgcg cacggccgcg gcgaccgccc
     7861 gcaggccggt gacgcaggcg gcctgagagc cgtcatgagg ccgcggacgg cctgaggatc
     7921 tgccgggggc cgctcgggag ggtgccgctc ttgtcctcgc cctcacgtgc atgactgtct
     7981 tcccccgtcc ccccccgcac cccggaaggc tcgttaccga cgtcaccgac gtcacgggcg
     8041 agaccctcct caccgacgtc acactcgtca tcgctcagcg cctggaagac cacgacccgc
     8101 cgaggaagcc ccgccgccac ggaggctccg ggcggggggc ggggtcggta ggcgtggtcg
     8161 gggagcggcc ggtcaggcgg tcgcggggcg agcggtcgac agggacggtt cgaggacgtc
     8221 ccagacctcg cgtacgagat cggcggggcc ggtcgtgtcc gtcgcccgca ccacggcggg
     8281 ggccccgacc aggagcgcca cggcgagctg ggcgaggagt ccggcgggat gggcgtcgga
     8341 caccgagccc tcctcctggc ccctgcggat caacagctcg acgacaccgc agagttcacc
     8401 gagctggacg gggacggttc cttcggcgcg ggccgcgtcc atgaccaggc ggaggccggc
     8461 ggcgaagggc aggtcctcgt acaccctgcg gctcagctcg acgagcagtc cgcgcagggc
     8521 ggtcagtgcc gtgccccgtt gggcggtggc gcccgccccc cgggtggcgg cggtggcgag
     8581 ggcgtcggcc cagcgcgact cgaaggagcg ggtcagttcg ccggcgaggt ccgccttcga
     8641 cgagaagtgt ccgtagaggg ctcctttggt cagtccggtg cgggccgtga tgtcggccag
     8701 gttcgtcccc gcgaatccgt gcagggcgaa ctcggcggca gcggcgccga gcaccaggtc
     8761 gtaggtcatg cgggccctgt cctgttgctt caccgagcgt ccgcctcccg tcgctgtgtt
     8821 cgtgttcctt cggacctcca tggatgcatg acggccccac agaaaatacc ttccagaccg
     8881 aatctttttc tactcgcatc agtaccacca ctcaaggagt ccacgtcatg acggtcgtcg
     8941 acacgcccgc ttccctcgcc accggatacc tgtacgccgc cgcagcgcgc cacgcggagg
     9001 ggtcggaacg gagcggacgg ctccaccccg aggtcgtcac cgcgatgacc gccgccgggc
     9061 tcgcccggca cttcgtcccg cgccgctggg gcggccgggc cggcgggttc gccgaactcc
     9121 tcgacaccgt cgccgaggtg gggacggcct gcgcgtccac cgcctggtgc ggggcgctgc
     9181 tcgcggccca cggccggctc gccgcgcacc tgccggtcga ggggcagcgc gaactgtggg
     9241 gcgactcgcc ggacacccgc gtggcggcgg cggtggtgcc cccggcgggg cggctccggc
     9301 gggtgccggg agggtggcgg ctgtcggggg agtgggcgtt cgcgagcggg gtggaggacg
     9361 cggagtgggt gctgctcgcc tcgctcgacc actcgggggc cggggcgccc ggctaccggg
     9421 tcctggcggt gccgcgtgaa cgggtcggga tcagggagac gtgggacgcg gtggggctgc
     9481 gggcgacggg cagccacagc gtggtgatcg aggaggcggc ggaggtcttc gtaccggagc
     9541 accgcacgtt cctgcgcgag acgctggtga cgggggtggt gacgggggcc gtcgacccgg
     9601 gggagggcgc ggccgggagc gaggccggcg acgcgcccgc cgaggtggcc ccgtgccacc
     9661 gggtgccgta ccagctggtc gcgtccctcc agttcgcggc gccggcgctg ggcgcggcgc
     9721 ggggagcgct ggaggcgtgg acgctgatga cggggttacg ccgcctcccg gacggccggc
     9781 cgctgacgga ggacccggtg gtccagcaga cgctgtcccg cagcgcggcg gagatcgacg
     9841 cggcgcacct cctgctgaag gcggcggcga cccgggcgga cgactggccg ggcggggccg
     9901 cgggggcgag ggacgcccgc gaggcggtca ccgcgctcaa ccaacgcgac gcggcggggg
     9961 ccgtggacct gctggtgggc gcggtggagc ggctgatgcg ggccggcggc gcgcggggcc
    10021 tgatcgcggg cggcggcctg gagcgcgcct ggcgcgacgt ccacgcgata gccgcgcacg
    10081 cggccctcca accggccccg gcggcggccg cctacgcggc gacggtgttc ccgacgtcac
    10141 cctga
//
