LOCUS       BGC0002579              7750 bp    DNA     linear   BCT 20-OCT-1997
DEFINITION  Carnobacterium piscicola transposase, bacteriocin, histidine protein
            kinase, ATP dependent transloactor, accessory protein, and
            carnobacteriocin B2 genes, complete cds.
ACCESSION   BGC0002579
VERSION     BGC0002579
KEYWORDS    .
SOURCE      Carnobacterium maltaromaticum
  ORGANISM  Carnobacterium maltaromaticum
            Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
            Carnobacterium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 18:02:23
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..147)
                     /codon_start=1
                     /note="ORF-4; putative"
                     /product="bacteriocin"
                     /protein_id="AAB81302.1"
                     /transl_table=11
                     /translation="MNKEFKSLNEVEMKKINGGSAILAITLGIFATGYGMGVQKAINDR
                     RKK"
     protocluster    1..7750
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2782:7721]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2783..7721
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..7750
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..7750
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002579"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..7750
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /subregion_numbers="1"
                     /tool="antismash"
     regulatory      complement(156..161)
                     /regulatory_class="ribosome_binding_site"
     CDS             complement(169..324)
                     /codon_start=1
                     /note="ORF-5; putative"
                     /product="bacteriocin"
                     /protein_id="AAB81303.1"
                     /transl_table=11
                     /translation="MKSVKELNVKEMQQTIGGWGWKEVVQNGQTIFSAGQKLGNMVGKI
                     VPLPFG"
     regulatory      complement(334..339)
                     /regulatory_class="ribosome_binding_site"
     regulatory      complement(355..360)
                     /regulatory_class="minus_10_signal"
     regulatory      complement(376..381)
                     /regulatory_class="minus_35_signal"
     regulatory      472..478
                     /regulatory_class="minus_35_signal"
     regulatory      496..501
                     /regulatory_class="minus_10_signal"
     regulatory      536..540
                     /regulatory_class="ribosome_binding_site"
     CDS             549..674
                     /codon_start=1
                     /note="ORF-6; putative"
                     /product="bacteriocin"
                     /protein_id="AAB81304.1"
                     /transl_table=11
                     /translation="MKIKTITKKQLIQIKGGSKNSQIGKSTSSISKCVFSFFKKC"
     regulatory      704..709
                     /regulatory_class="ribosome_binding_site"
     gene            717..2045
                     /gene="cbnK"
     CDS             717..2045
                     /codon_start=1
                     /gene="cbnK"
                     /product="histidine protein kinase"
                     /protein_id="AAB81305.1"
                     /transl_table=11
                     /translation="MFSIDTKAYILSIFLSLFYFYGIFFSLYQTVSLRKRIVIVFILLP
                     ITFIGSIFTVFADILPMVGCYYILKKQKKTDYILLNLIITSMLTSYFVSVVGSSVIIPF
                     FSFSGVKSFSFVFINSGIQLLVLVITILLFRYFSIGDRIKKYSSPSLSFLLCYLYLVSF
                     LLLYAARYYEAFDKFVAGITFFFIIQTIFIVYIFIREKETQLEKYKHKLSQQQLVDLKR
                     YTDQLEENQQKLRKFKHDYENLLLSLKDVVGEGQNEEAIQSIGELEKYSKENLSFISGY
                     YKDIENIENTYLKSLIINKLFTIQNNDIICDFECKEVVQIVPMSIFDFVRVVGITLDNA
                     IEGAETADTPKISILIYQDKRQLELVVENTSQSTNIPLSRLMIQGTSSKENHKGLGLSN
                     IQEIKKSHPNLYKQYEKKINKFSANIIVLFESEEFHELPNYHL"
     regulatory      2010..2014
                     /gene="cbnK"
                     /regulatory_class="ribosome_binding_site"
     gene            2020..2757
                     /gene="cbnR"
     CDS             2020..2757
                     /codon_start=1
                     /gene="cbnR"
                     /product="response regulator"
                     /protein_id="AAB81306.1"
                     /transl_table=11
                     /translation="MSYPIIICEDQLPQLHQLETIVQNYILFHSDVFKIVLKTQSPSEV
                     KKYLKQFHPKNGIYFLDIDLNHKINGIDLAETIRNSDSQAKIIFITTHDELAPLTLKRR
                     IEALGFVAKNQPLENYRFEIIELLSIAKERIDFTKTDLKMNFTFSIGSQIFNFDLDEIL
                     FLEPSEIPHRIQLYTVNGQYEFYDTISAIEKRYQNLFRISRFCLINPLNITEVNFSNRT
                     VYFDDFSRSFSIGKAKKLKEILK"
     regulatory      2768..2773
                     /regulatory_class="ribosome_binding_site"
     gene            2783..4933
                     /gene="cbnT"
     CDS             2783..4933
                     /codon_start=1
                     /gene="cbnT"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 291.9; E-value:
                     1.6e-88)"
                     /gene_kind="biosynthetic"
                     /product="ATP-dependent translocator"
                     /protein_id="AAB81307.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.8e-51, bitscore:
                     161.4, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 2.2e-259, bitscore:
                     851.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASISFVQQQDEKDCGVACIAMILKKYKSEVPIHKLRELSGTSLE
                     GTSPFGLKNCIEKLGFDCQAVQADQEVWNEKELPFPLIAHVVINKTYMHYVVVYGVKEN
                     KLLIADPAEGKMKKSIENFSEEWSGVLLLMTPKNSYQPTKEKVDGLSSFLPIVWKEKTL
                     VFNIILAALFITFFGIGSSYYFQGILDYFIPNQARSTLNIVSFGLIIVYLFRVLFEYSR
                     SYLLVILGQRMSMAVMLRYFNHVLNLPMNFFATRKSGEIISRFLDANKIVDALASATLS
                     VFLDIGMVLLVGVTLAIQNGTLFLITVASLPFYLVAILAFVKSYEKANQDEMKAGATLN
                     SSIIESLKGIETIKAYNGEEKVYNRVDQEFIQLMKKAFRTSTLDNIQQGVKQGIQLISS
                     GIILWIGSYYVMGGTISLGQLITYNALLVFFTDPLQNIINLQVKMQTAHVANKRLNEIF
                     AIETEHKETDTEKIISKDTFQQGIIFDNVSFSYNINSSTLKNISCVFPPRSKIALVGVS
                     GSGKSTLAKLLVNFYPPSEGMICYGKINYLDIGYQNLRENVTYVPQESFFFSGTILENL
                     LFGLDYQPTFEQILDICHVTQLMDFISKQPLRFETILEEGASNLSGGQRQRLAIARALL
                     KNADILILDEATSGLDTLLEHAILENLLQLKEKTIIFIAHHLAIAKACDQVVVLHEGKL
                     VEQGTHDELRYNNGMYQRLWEI"
     regulatory      4935..4940
                     /regulatory_class="ribosome_binding_site"
     gene            4949..6316
                     /gene="cbnD"
     CDS             4949..6316
                     /codon_start=1
                     /gene="cbnD"
                     /product="accessory protein"
                     /protein_id="AAB81308.1"
                     /transl_table=11
                     /translation="MQTNKWLDSSSVYSQQHSKFYLWVLYPIVVLFFLLGLFLVFARKE
                     VVIRMPAKITAETISKLQAPIETKITENYLYENKVVKKGEIVVVFDTLSLENEQKQFED
                     EVLVLEEQKKAAQTFIISVENNENQFVADDSFGYANQLNALFAEQESIQYITQQATDLS
                     EINQEAYKKTEEQLDFQLTKRLNAQSEWEQVKKAWGNQQEVQEFSTEIISKYKTWQLQV
                     NDATEEQKNQVIAAILSTIDENIAELKKEIEQIQGEKAKLIAPTTSKNEINSGNAKVKQ
                     NKEQLLAKTKQDIIEFDDKQKKIEVSIKQLKEKIQQGMLKAPIDGTISLNEEFKTMIDI
                     PKGALIAEIYPTTGNREQMFTAQLPANEMTRIKKGMNVHFTLDKKGVAAKIVDGKLTGI
                     SETSETTENGTFYTITGKIKIPKNFSIRYGLTGEISLIVGKKTYWQQIKDTLLNVE"
     regulatory      6426..6453
                     /regulatory_class="terminator"
     regulatory      6950..6955
                     /regulatory_class="minus_35_signal"
     regulatory      6974..6979
                     /regulatory_class="minus_10_signal"
     regulatory      7050..7054
                     /regulatory_class="ribosome_binding_site"
     CDS             7074..7403
                     /codon_start=1
                     /note="ORF-7; unknown function"
                     /protein_id="AAB81309.1"
                     /transl_table=11
                     /translation="MKNFIKQDNFVYVLLTFFIIPDWEYPIFTVICYLSGLCFLFTLRK
                     QKNKKIEIVAFFFMFVASIMGIFIFESFYSTIIYACYAIAIVYTIFTMRKDSYENNKNN
                     RKKVI"
     regulatory      7450..7455
                     /regulatory_class="minus_35_signal"
     regulatory      7474..7478
                     /regulatory_class="minus_10_signal"
     regulatory      7505..7510
                     /regulatory_class="ribosome_binding_site"
     gene            7521..7721
                     /gene="cbnB2"
     CDS             7521..7721
                     /codon_start=1
                     /gene="cbnB2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_II"
                     /gene_kind="biosynthetic"
                     /product="carnobacteriocin B2"
                     /protein_id="AAB81310.1"
                     /sec_met_domain="Bacteriocin_II (E-value: 1.5e-20,
                     bitscore: 62.0, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSVKELNVKEMKQLHGGVNYGNGVSCSKTKCSVNWGQAFQERYT
                     AGINSFVSGVASGAGSIGRRP"
     regulatory      7744..7750
                     /regulatory_class="ribosome_binding_site"
ORIGIN
        1 ttattttttt cttcgatcat ttatagcttt ttgaactccc atgccgtaac cagtagcaaa
       61 aattcctaga gtaatagcta aaatagctga tcctccattt atttttttca tttcgacttc
      121 atttaaagat ttaaattctt tattcatgtg aaaaacctcc tttttttatt aaccaaatgg
      181 taagggaact attttcccaa ccatgttacc cagtttctga ccagctgaaa aaatagtttg
      241 tccattttga acaacttcct tccatcccca tcctccaata gtttgttgca tttcttttac
      301 atttaattcc ttaacacttt tcatcaaaat taacctcctt tggtttatat ttgtattaca
      361 acgagactat accatatctg aaaaaattta aggtgaaaac atcctgagct tatttgtttg
      421 agttcttgaa aaaagaaaat tctaagttta ttcattcaag accgtattcg atgtagttca
      481 ggatgttttt tcatatataa taaaatttta tgccatactt taattaaaca agcgagaggg
      541 gaatagatat gaaaataaaa acaataacca agaaacaact tattcaaata aaaggaggaa
      601 gtaaaaatag tcagattgga aaatcaacat ctagtatttc aaagtgtgta ttttctttct
      661 tcaaaaaatg ctaaaagctt ttaaattctg atatactcta aataggaggg attcagatgt
      721 tttctattga cacaaaagca tatattttaa gcatattttt atcacttttc tatttttatg
      781 gtatattttt tagtttatac caaacagtgt ctcttagaaa aagaatagta atagtattta
      841 tattattacc aattacattc ataggctcta tttttactgt ttttgcagat atacttccaa
      901 tggtagggtg ttattacatt ctaaagaaac aaaaaaaaac agactatata ctattgaatc
      961 taatcattac aagcatgcta acgtcttatt ttgtttcagt agtaggttca tcagtaatta
     1021 tcccattttt ttctttttct ggtgtgaaaa gcttttcttt tgtgtttata aatagcggta
     1081 tccaattatt agtcttagtg ataacgattt tgttgtttcg ttactttagt attggggacc
     1141 gtattaaaaa atacagttct ccttcgttat catttctact ttgttatcta tatttagtaa
     1201 gttttctctt actgtatgct gctcgatact atgaagcatt tgataaattt gttgctggta
     1261 taacattttt ttttattata caaactatat tcattgttta tatatttata cgagaaaaag
     1321 aaacgcagct agaaaagtac aaacataagt tatctcagca acagttagtt gatttaaaaa
     1381 gatatacgga ccaattggaa gaaaatcaac aaaaattaag gaaatttaag cacgactatg
     1441 agaatctcct actcagctta aaggatgtag taggagaagg ccagaatgaa gaggcaattc
     1501 aaagtattgg tgaattagaa aagtactcaa aagagaatct atcttttata tcagggtact
     1561 ataaggatat tgaaaatatt gaaaatactt atttaaaaag tcttataatt aacaagctgt
     1621 ttacaattca aaataatgat attatttgtg attttgaatg taaagaagtt gttcaaatag
     1681 ttcctatgtc aatatttgat tttgttcgtg ttgttggcat tacgctagat aatgctatag
     1741 agggcgctga aactgctgat acaccaaaaa tatctatcct tatttatcaa gataaacgcc
     1801 aattggaatt agtagttgaa aatacatctc agtcaactaa tattcctctt tcacgattaa
     1861 tgatacaagg aacttcttcg aaagaaaatc ataaaggact tggtttgtcg aacattcaag
     1921 aaataaaaaa gtctcatcca aatctttata aacaatatga aaaaaagatt aataaatttt
     1981 ctgcaaatat tatagtccta tttgaaagtg aggaatttca tgagttaccc aattatcatt
     2041 tgtgaagatc agcttccaca attgcaccaa cttgagacga ttgttcaaaa ttatatctta
     2101 tttcactctg atgtatttaa aattgtactt aaaacacaaa gtcctagtga agtgaaaaag
     2161 tacctcaaac aatttcaccc taaaaacgga atttactttt tagatatcga tttaaatcat
     2221 aaaataaatg gaattgacct tgcggaaaca attagaaact cagatagcca ggcaaaaatt
     2281 atttttatta caacccatga tgaattggct ccattgacat tgaaacgtcg gattgaagcg
     2341 ttgggatttg ttgccaagaa tcaaccatta gaaaattacc gatttgagat tatagaactt
     2401 ttatccattg caaaagaaag gatagatttt acaaaaacag atttgaaaat gaattttact
     2461 ttttcgattg gatctcaaat ttttaatttt gatttagacg aaatcctttt tttggaaccc
     2521 tctgaaattc ctcatagaat acaattatat actgttaatg gacagtatga attttatgat
     2581 actatcagtg ctatagaaaa acgttatcaa aatttattta gaataagtcg attttgttta
     2641 attaatccat tgaatattac agaagttaat ttcagtaata gaacagtgta ctttgacgat
     2701 ttttcaagaa gtttttctat tggaaaagct aaaaaattaa aagaaatctt aaaataatat
     2761 aaaaattgaa ggaagtgtaa aagtggcctc aatttcattt gtccagcagc aagatgagaa
     2821 agattgtggt gttgcatgta tcgcaatgat tttaaagaaa tacaaatcag aagtcccaat
     2881 ccataagtta agagaacttt cagggacaag cctagaggga acttcaccat ttgggttaaa
     2941 aaattgtatt gaaaaattag gttttgattg ccaagctgtt caagcagatc aagaagtttg
     3001 gaatgaaaaa gagttgccct ttccattaat tgctcatgta gtaataaaca aaacttatat
     3061 gcattatgtc gttgtgtatg gcgtcaaaga aaataagcta ttgattgcag atccagctga
     3121 aggtaaaatg aaaaaatcta ttgaaaattt ttcggaagaa tggtcagggg ttcttttatt
     3181 aatgactcca aaaaattctt atcagccaac taaagaaaaa gttgacggat taagttcatt
     3241 tttacccatt gtgtggaaag aaaaaactct tgtttttaat attattttag cagcgctttt
     3301 cattactttt tttgggattg ggagttctta ttattttcaa gggattttag attactttat
     3361 tcctaatcaa gcacgttcca ctttaaatat tgtttctttt gggctaataa ttgtctattt
     3421 atttcgtgta ctcttcgagt atagtcgtag ttacctatta gtaattctag gtcaacgcat
     3481 gagtatggca gttatgctac gttattttaa tcatgtgtta aatttaccaa tgaatttttt
     3541 tgccactcga aaatcaggag agattatttc tagattctta gatgcgaata aaattgttga
     3601 tgctttagca agtgcgacgc tttctgtttt tttagatatt ggtatggtac ttttagttgg
     3661 agtaacgttg gcaattcaaa atggaacact tttcttaata acagtagctt cattgccttt
     3721 ttatctagta gctattctag cttttgtgaa aagttatgaa aaggctaatc aagacgaaat
     3781 gaaagcagga gcaacattaa attccagtat tattgaaagt ttaaaaggaa tagaaacgat
     3841 aaaagcttat aatggggaag aaaaagtcta taatcgagtg gaccaagaat ttatccaatt
     3901 gatgaaaaaa gcttttcgta cttcaacttt agataatatt cagcaaggag ttaaacaagg
     3961 tattcaacta attagtagtg gaattatttt gtggataggt tcgtattacg taatgggtgg
     4021 aacaataagt ttaggacaat taattactta caatgcatta ctcgtttttt ttactgatcc
     4081 attacaaaat attatcaatc tgcaagtgaa aatgcaaacc gcacatgtcg caaataaaag
     4141 actgaatgaa atatttgcaa tagaaactga acataaagaa accgatacag aaaaaataat
     4201 ttcgaaagat acattccaac aaggcattat atttgataat gtttcatttt cttataatat
     4261 aaactcatca actttaaaaa atatttcttg tgtatttcca cctcggagta aaattgcttt
     4321 ggttggagtt agtggttctg gaaagtcaac gctagcaaag ttattagtaa atttttatcc
     4381 tccttctgaa gggatgattt gctatggaaa aataaattac ttagatattg gctaccaaaa
     4441 tttacgagaa aatgtaacat atgtaccgca agagtcattt ttttttagtg ggacaatttt
     4501 agaaaattta ctttttggat tagactatca gccaactttt gaacaaattt tagatatatg
     4561 tcacgtaacg caactaatgg attttatatc gaaacaacct ttacgctttg aaacaatttt
     4621 ggaagaaggt gctagtaatc tttctggtgg tcaaaggcag cgcctagcaa ttgctagagc
     4681 gttactaaaa aatgcagata tattgatatt ggacgaagca acaagcggac tagatacact
     4741 attggagcat gctattttag aaaatttgct acagttaaaa gaaaaaacta taatatttat
     4801 tgcccaccac ttagcgattg ctaaggcttg tgatcaagta gttgttcttc acgaagggaa
     4861 acttgtggag caagggactc atgatgagtt gcgttataat aatggtatgt atcaacgact
     4921 ttgggaaatt taaaaaggag ttaccaatat gcaaacaaat aagtggcttg attcctccag
     4981 tgtatacagc cagcaacata gtaaatttta tctttgggta ctgtatccca tcgttgtttt
     5041 gtttttttta ttaggcttat ttttagtttt tgcaagaaaa gaggtagtta ttcgtatgcc
     5101 cgctaaaatt acagccgaaa ctattagtaa gttacaagca ccaattgaaa ccaaaataac
     5161 agaaaattac ttatacgaga ataaagtcgt aaaaaaaggt gaaatagtgg ttgtttttga
     5221 tacattatct ttagaaaatg aacaaaagca atttgaagat gaagttttag ttttagagga
     5281 acaaaagaaa gcagcgcaga cctttattat tagtgtagag aataatgaaa atcaatttgt
     5341 agcagatgat tcatttgggt atgcaaatca attaaatgct ctatttgcag aacaggaatc
     5401 tattcaatat attacacaac aagcaacaga tttgagtgaa ataaatcaag aagcttacaa
     5461 aaaaacagaa gagcaactgg attttcaact aacaaaacga ttaaatgcac aaagtgaatg
     5521 ggaacaagtc aaaaaagctt ggggaaatca acaagaagta caagaatttt ctacggaaat
     5581 tatttcaaaa tataaaactt ggcaattaca agtgaacgat gctactgaag aacaaaaaaa
     5641 tcaagtaata gcagccattt tatctacaat tgacgaaaat attgcagaat tgaaaaaaga
     5701 gattgaacaa attcagggtg aaaaagcgaa acttatagca cccactacat caaaaaatga
     5761 aataaatagc ggaaatgcta aggtgaaaca aaacaaagaa caactattag ctaagactaa
     5821 acaagacatt atagaatttg atgacaagca aaaaaaaatt gaagtgtcta taaaacaatt
     5881 aaaagaaaaa attcaacagg gaatgttaaa ggcacccatt gacggtacta tttcacttaa
     5941 tgaagaattt aaaactatga tagatattcc taaaggggct cttattgccg aaatttatcc
     6001 aactactgga aatagggaac aaatgtttac cgctcaacta cctgctaatg aaatgacacg
     6061 tattaaaaag ggaatgaatg ttcattttac attggataaa aaaggcgtcg ctgcaaaaat
     6121 agttgatgga aaattaacag gaatttcaga aacaagtgaa acaacagaaa atggaacttt
     6181 ctatactatt acagggaaaa ttaaaatacc aaaaaacttt agtattcgct atggccttac
     6241 tggagagata tcgctgattg ttggaaaaaa aacatattgg caacaaatta aagatacatt
     6301 attaaatgtg gaataataac ttaaagactt agtttaaaaa aagaaaagaa agaatggagg
     6361 ggactatttt gataggcatt attgtagcaa taagcggttt gataggtatg atgttactct
     6421 ataaaaatgt agaaatacac ctatttctaa gttcggattt actatttatt ggaccagttt
     6481 tactaatctc tttattctat ggtgtagttt ctagtacaga tataatgagt attaaatgtc
     6541 aactattata gatttattat tgctagtaat gagtttaata ggtattatac tagttttatt
     6601 atcttataaa ccaaagggat taactaaact agctcgctac ggatattttt tagttatttt
     6661 atatttaata ggttttagct gcattatttt gttttacgga taggtaaaat atgaaactat
     6721 tttacgttta gaaatctata tttttcttac tataagggag gatgagcgat gatagaattt
     6781 ataatagacg tatttttaat actagccgat actattcaat taaaaaaggt gagaaaacag
     6841 ttaaaaaaaa gaaaaaatca ataaaataat tacatcatat attcttctac taatttagaa
     6901 gtgtgagaaa atggtctaat tttttagttt attatgtata aaaaataatt tgatggaaaa
     6961 tgtactaaaa atgcttaata gtaataacaa ttatttaagc gttttcaaaa tattttaaga
     7021 gatttataca ttttgaatta ttttttagaa aggattgaaa tatggagcat aaaatgaaaa
     7081 attttattaa acaagataat tttgtatacg tgttacttac attttttatt attcctgatt
     7141 gggaatatcc tatttttaca gttatatgtt atcttagtgg tttatgtttt ttatttactt
     7201 tacgtaaaca aaaaaataaa aaaatagaaa tagttgcttt tttttttatg tttgtagcaa
     7261 gtattatggg aatatttatt tttgaaagct tttatagtac aattatttat gcgtgctatg
     7321 caatagctat tgtatatact atttttacta tgagaaaaga ttcttatgaa aataacaaaa
     7381 ataatcgtaa aaaagttata tagcatttat ttcatttatg aattcaaata ccctggttca
     7441 agatgtattt tccaaaaaaa tgttcagata tgatatagtt tttttgaaat acaaatataa
     7501 aataaaggag tttgatttag atgaatagcg taaaagaatt aaacgtgaaa gaaatgaaac
     7561 aattacacgg tggagtaaat tatggtaatg gtgtttcttg cagtaaaaca aaatgttcag
     7621 ttaactgggg acaagccttt caagaaagat acacagctgg aattaactca tttgtaagtg
     7681 gagtcgcttc tggggcagga tccattggta ggagaccgta aatatataaa tacaatatag
     7741 agcaaggtgg
//
