BGC0002581: bosamycin A biosynthetic gene cluster from Streptomyces sp.
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Location: 1 - 46,839 nt. (total: 46,839 nt).
This entry is originally from NCBI GenBank MN509472.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002581
Short description bosamycin A biosynthetic gene cluster from Streptomyces sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MN509472.2
5861 - 42927
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • bosamycin A
  • bosamycin B
  • bosamycin C
  • bosamycin D
  • bosamycin E
  • bosamycin F
Species Streptomyces sp. [taxonomy]
References
Chemical products information
bosamycin A Evidence:
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Chemical database entries
NPAtlas
bosamycin B Evidence:
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Chemical database entries
NPAtlas
bosamycin C Evidence:
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Chemical database entries
NPAtlas
bosamycin D Evidence:
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Chemical database entries
NPAtlas
bosamycin E Evidence:
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Chemical database entries
NPAtlas
bosamycin F Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QKF54434.1
 5861 - 6115 (-) acyl carrier protein
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    • QKF54435.2
    		 6180 - 13997 (-) nonribosomal peptide synthetase
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      • QKF54436.1
      		 14664 - 24260 (+) nonribosomal peptide synthetase
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        • QKF54437.1
        		 24351 - 25292 (+) dioxygenase
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          • QKF54438.1
          		 25386 - 37238 (+) nonribosomal peptide synthetase
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            • QKF54439.1
            		 37270 - 37479 (+) MbtH protein
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              • QKF54440.2
              		 37713 - 41123 (+) P450+A+T
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                • QKF54441.1
                		 41120 - 41938 (+) alpha/beta hydrolase
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                  • QKF54442.2
                  		 41935 - 42927 (+) O-methyltransferase
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                    Biosynthesis information

                    Biosynthetic modules

                    Name
                    Unk01
                    Type
                    nrps-type1
                    Genes
                    QKF54435.2
                    Substrates
                    tyrosine (evidence: ATP-PPi exchange assay, Structure-based inference)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk02
                    Type
                    nrps-type1
                    Genes
                    QKF54435.2
                    Substrates
                    tyrosine (evidence: Structure-based inference [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk03
                    Type
                    nrps-type1
                    Genes
                    QKF54436.1
                    Substrates
                    leucine (evidence: Structure-based inference [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk04
                    Type
                    nrps-type1
                    Genes
                    QKF54436.1
                    Substrates
                    aspartic acid (evidence: ATP-PPi exchange assay, Structure-based inference)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk05
                    Type
                    nrps-type1
                    Genes
                    QKF54436.1
                    Substrates
                    serine (evidence: Structure-based inference [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk06
                    Type
                    nrps-type1
                    Genes
                    QKF54438.1
                    Substrates
                    5-methoxytyrosine (evidence: ATP-PPi exchange assay [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk07
                    Type
                    nrps-type1
                    Genes
                    QKF54438.1
                    Substrates
                    leucine (evidence: Structure-based inference [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk08
                    Type
                    nrps-type1
                    Genes
                    QKF54438.1
                    Substrates
                    glycine (evidence: Structure-based inference [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk09
                    Type
                    nrps-type1
                    Genes
                    QKF54440.2
                    Substrates
                    tyrosine (evidence: ATP-PPi exchange assay [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Annotation changelog

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Entry added
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Added NRP substrate specificities
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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