LOCUS       BGC0002584             13427 bp    DNA     linear   BCT 20-MAR-2016
DEFINITION  Streptomyces sp. FXJ1.264 putative azolemycin biosynthetic gene
            cluster, complete sequence.
ACCESSION   BGC0002584
VERSION     BGC0002584
KEYWORDS    .
SOURCE      Streptomyces sp. FXJ1.264
  ORGANISM  Streptomyces sp. FXJ1.264
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 18:02:54
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13427
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..480)
                     /codon_start=1
                     /product="conserved hypothetical protein"
                     /protein_id="AMQ23501.1"
                     /transl_table=11
                     /translation="MSTPTTSRKRGSSDKTKTATKATARKTAAERKTTGRQKSAATKST
                     ASEKATATPAKAGTKAEKPPVTTSSGDGKRSFTVTVPTAGRVASGLADAALLPVAVARR
                     WLPAKGGLPLYVGLGVLGAVEVIEWPVAVGIGIGYAVLRRGGVMAPPSTGAAQPA"
     source          1..13427
                     /db_xref="taxon:634337"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. FXJ1.264"
                     /strain="FXJ1.264"
     misc_feature    1..13427
                     /note="putative azolemycin biosynthetic gene cluster"
     subregion       1..13427
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="ribosomal"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..13427
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             755..5101
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1037:heavy metal
                     translocating P-type ATPase (Score: 493.7; E-value:
                     1.6e-149)"
                     /gene_kind="other"
                     /product="haloacid dehalogenase"
                     /protein_id="AMQ23502.1"
                     /transl_table=11
                     /translation="MRGAAGLLGRLARLPQRGVWTHPGRVYIEVRGVHGTGGERVARRV
                     ETALETHPRVRWARVNAPSERVVVSLLSQAVREAELIALVEQGEESEAAAVVEEFDEWL
                     PEPHHPSEGPSTPESLSALTADAVGLTLATALRLAPWLKLPTEVGALASLLQHHPRIRR
                     LAAAIGGPDRSDSALTAVSALAQGVATRGGGLALDVVERLAQWREAAAERQAWEAAEPH
                     LVHGPRDVEAEPIVVERPAPPPRDATARYAERSMWIGAAVGALAVPFAGPRRGLAVALA
                     SIPKAPGAGREGFATSLGHFLALRGVVAMDRGALRRLGQVDTVVLDEEALRGDRYEPVD
                     VEVLGGADAPRVAERLFDLFDPDGPLEVRRNGHGWALGPLDRLDLTGRTGGQAASRLLR
                     KGSERVLGLARGHRLQAVVGLAAQTAPGAEAVAAAARRAGARVVLATDRPHPAFAFADA
                     VVPAGGRLVASVRGLQADGAVVLLLSGNRRALGAADCGIGTHREGEAPAWGAHLLVGAD
                     LESAAVIVDAVGVAARVDRDSAVLAAGGSGVGAVAALQAHRRHSAARSTGVGNTAGTIA
                     FCMGNWRARQLITRPLAPPVTSVPWHLMPARRVLDRLGTAPEGLTPAEAAARARAPGGP
                     RTGEPPRTSLPAAFIDELANPLTPVLAAGAALAAAVGSRTDAALVAAITGTSALVGGVQ
                     RVRTERALAELFSRSAIGARVRRAGTERLVAAGDLVPGDIVVLRPEDVVPADCRLLEAE
                     GLEVDESSLTGESLPVPKDPAPVTAGHITGRRSMLYEGTTVSAGRAVAVVVATGTSTEV
                     GRSLATARQAAPVTGVEARLTKLTRASLPIALGSASAVSAAGLLHGRKLTDTLAQSVNL
                     AVASVPEGLPFLVNAAQLAAARRLADLGALVRNPRTIEALGRADVLCFDKTGTLTEGTL
                     QLAAVGDGDHQLPADRLDTPRKAVLAAALRATPPARQAEPMAHQTDRAVMAGARRAGVA
                     VRQGAPRWRRTDALPFEPSRAYHATAGRTSHGLLLSVKGAPENVLRRCAGRRHRDAPAP
                     LDPDAVEELTARAEELAGAGRRVLAVAERPMADDEELTDEAVRDLVFLGFVALADPVRT
                     SAAPATRRLHEAGVHTVMLTGDHPATADAIAARVSDVPEPKVCTGPELDELDDAALDAL
                     LPTVDVIARCSPHHKVRIVQAYQRLGRVVAMTGDGANDAPAIRLADVGIALGRRGTPAA
                     TAAADLVVGDDRLETIVSALMEGRAMWASVRAALAILIGGNLGEVTFSVLTASLTGGTP
                     LSARQIMLVNLLTDLAPALAIAVREPTGHTGERLLREGPHVSLGTALTNEMLLRGGITA
                     LGAGLAWFGARLTGRRRRASTVALVALVGTQLAQTLATGGLDRHVLIAGLGSAAVLAGI
                     VQTPGVSHFFGCTPLGPVAWGITLGSIALATLSGAALPPLLRGLPR"
     CDS             complement(5098..6267)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119:halogenase (Score: 281.5; E-value: 2.3e-85)"
                     /gene_kind="biosynthetic-additional"
                     /note="AzmF"
                     /product="FAD-binding monooxygenase protein"
                     /protein_id="AMQ23503.1"
                     /transl_table=11
                     /translation="MYDVIVVGGRCAGAATALLLARQGHRVLVLERARFPSDTLSTLYI
                     HQPGVDRLARWGVLEEVRATGCPPLERISFRAPGLLLTGPAPVWGAATGGLAPRRYALD
                     AILARAAARAGAEFRHGCSVTGLLWEGGAVAGVRYATPRGGADRARARLVVGADGRNST
                     VARLVGAPYLRDDGRLTVALYTYWSGLPGDGLGLYSTRGAGAALVPTQDGLTLVNVQLP
                     RATPGLTRESAPRAYLAGALRACPDLAEPLAAARQEDRLFRCTDLRNFFRRAHGPGWAL
                     VGDAGHHKDPCGAQGIGDAFAQAELLAGCLAEAVDDPGLTAKALRRYAEERDRRWTPPY
                     ESNLAFARLSPSEDHLAALRRGETDPLFRDRFFRALAGIPDGDEEPGGH"
     CDS             6435..6653
                     /codon_start=1
                     /product="AzmA"
                     /protein_id="AMQ23504.1"
                     /transl_table=11
                     /translation="MTGFARPHFHGTGPNTPLSGPSSGRDRIRIRSTGDSPVIDNDLFE
                     EMAIQEPEAVVVSTCTIKMDEDIEETQ"
     CDS             6805..8898
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03604"
                     /gene_kind="biosynthetic"
                     /note="AzmB"
                     /product="SagB-type dehydrogenase"
                     /protein_id="AMQ23505.1"
                     /sec_met_domain="YcaO (E-value: 3.7e-71, bitscore: 229.7,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 1.6e-77, bitscore:
                     250.0, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLVNRAGHVYICSSTGTLRVPQRNPELSELEGDIGLEFLPDDVI
                     AGLRSRTLVHSASDAPLSHPLYDTGGPDATRPAVVVGEGPLADGVAERLRRAGAEAVRA
                     PAPDRSADPGALVLPLHGDEALLRRWTERAMDARAPILTHLSSPTRLLFAVLDPPRTAC
                     PVCLVRRLRANHSWQPIADLPLDVLYGAAESDRWPTTAIAAAMLAHQTMAALTRGPSGP
                     AELLEVDHATLVTTRHPALHTPLCPACAPVAAPPEPAEPPAVDPESCWERMRRAVDPLT
                     GLVAEVRVRDADREPGNSTTHVLTAGHPTTTWFSPVQASSCSGAVKHDPTLARVCAVGE
                     FMERYAAGVYDPDRLVRASFRKLGAAAVDPRSLPLASEREYAALSRIAPFDPDLELDWV
                     EGRSLTTGRSRYVPACAVYVPYRFPRRRERLIDPISTGLAAGSGPHHATLGGLLEVVER
                     DAAAVFWENRLALPTLDLGGLTGGPAAAIVERLTAAGVQVLCKDLTTDLGIPAVSVRYV
                     EGPADRPVVAHATSAHLDLHGALLGALEEADLCRTGLRSWLAERDIPGVDDIELDRSDF
                     YTYYCGPGRLSLVPFWDEGPLRPLPAPSPTPASHQAAVEEVVRRLAARGYEPIAVDITP
                     VDVAECGVRVVRSVVPGLCPITLRRDFRRRGGRRLYEAPVRMGLRAAPLTEDELNPYPL
                     PLG"
     CDS             8919..10121
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /note="AzmC/D"
                     /product="YcaO-domain containing protein"
                     /protein_id="AMQ23506.1"
                     /sec_met_domain="PF00881 (E-value: 2.3e-14, bitscore: 43.1,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAANGTAEQEKNATMTRQTLYRRRRDTLVEWGENGKLVLVDCGAW
                     RKFAIKPELLELLSLLDHPRSARDVHGAWASSSRPEDEVRRLLERLAEAGIVCRDAPED
                     DGPAPEADEAEARRDGAGEVPGPGGAPPGAGWTPYELAVHAQASRSGVPTRLRGTPPAA
                     RLLHPEALERIELPEDTAPPSRPLDRVLADRRSIRTYAPSPVPLPLLAALFARTARVRG
                     YLPPLKYEQTQRAAPSGGARHSLELYLVAREVEGLAPGAYHYDPFGHALERLAPWSEEL
                     DDLQRRTLCVPMQEDQPPPAGLYLTSCAYRTGWKYQGMALSLIYRDTGCLMQTLSLAGT
                     DIGLATCLTGRVESPMTPSFLRPYRDRLIHVGNMAIGLPAPISAAHRLVPLTADKEPER
                     A"
     CDS             10118..10990
                     /codon_start=1
                     /note="AzmE"
                     /product="isoleucine-carboxyl methyl transferase"
                     /protein_id="AMQ23507.1"
                     /transl_table=11
                     /translation="MTPADSEPPPLPTVCRTAVWTAQMRADESRVPNACAVDPWAAEFV
                     AAAGPQGPPPGGPEARSFLHDGVAVRTRYFDDYLLEAVAGGCSQVVLLGAGLDARAFRL
                     PWPRPVEVFEVDLPDLLDFKNRVVGGRAPAAARRVTVAADLRDAWAEALIAAGFDPARR
                     TAWLCEGTLVYLEPGQADAVVCTMAAHSPPGSEVGAETMTSQGRLDCLRSCHDALSADG
                     APWRCSLSDPAAWWAERGWRMTVPDPASLPYAAERMAPYLPMLRQAGDAGGWLLTGTRC
                     GPGPAAPPA"
     CDS             complement(11065..12084)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 202.5; E-value: 1.4e-61)"
                     /gene_kind="regulatory"
                     /note="AzmR"
                     /product="LysR family transcriptional regulator"
                     /protein_id="AMQ23508.1"
                     /transl_table=11
                     /translation="MMDLRQLTVLAEVSRAGSYRAAADRLGYTQPAVSYHMRALERAAG
                     VPLVARSGRGVRLTPAGHRLAERAQEVLTGLRAVESEFEALAAHTRGRVRVSAVQSVCV
                     AVLPAALALMRAASTEVEVELGQAASPDSYRLLRSGETDVAIVGDGDLGDLGAREPGSP
                     VGAADPALCRVPLLADRRYVLLPPGHALARRRSVALADLSGERWILGRERGRLLRRCAE
                     AGFEPRVVTTTDDQATTIGLVGDGVGVALLDGLGLLPRRDPRVRARRLNRWPRRQVYAL
                     LRPETAKMPAVAALMGAVRAAVGRLAESTDCLLPPGGEPPAPPGDASPRRAPGRVRPA"
     CDS             12390..13427
                     /NRPS_PKS="Domain: Aminotran_1_2 (26-325). E-value:
                     7.7e-43. Score: 138.8. Matches aSDomain:
                     nrpspksdomains_AMQ23509.1_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 138.7; E-value:
                     4.1e-42)"
                     /gene_kind="biosynthetic-additional"
                     /product="histidinol-phosphate aminotransferase"
                     /protein_id="AMQ23509.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.3e-43, bitscore:
                     138.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHDGWNRMRPVVAEDRPFHQMALNETVHPPLPEVLEAVARAGREA
                     HRTHDALGTALTRALAEHLGVEPEHILVGPGSGALLQQLFTTRTGPDTHTVHAWSSWEA
                     YPMMAANAGSTTVRVPLTDCHHDLRAMAAAVTDRTRMVLLCNPNNPTGTALRHERVRAF
                     LDELPGHVTVVVDEAYRDFADPGAIADGIDLYRGDERVCVVRTFSKSYGLLSLRVGYLV
                     GHDPVLAPIRAQLPFFRVSHVAQQAAIAALGAHEKVLQGCADTARERDRLRRALLDQGW
                     EVPVSQGNFLWLPMESGVERFTQFCADHAVVVCGKPGEGVRVTVAEPEAIEAFRQLAAK
                     YRESR"
     aSDomain        12468..13364
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMQ23509.1_Aminotran_1_2.1"
                     /evalue="7.70E-43"
                     /label="AMQ23509.1_Aminotran_1_2.1"
                     /locus_tag="AMQ23509.1"
                     /protein_end="325"
                     /protein_start="26"
                     /score="138.8"
                     /tool="antismash"
                     /translation="VHPPLPEVLEAVARAGREAHRTHDALGTALTRALAEHLGVEPEHI
                     LVGPGSGALLQQLFTTRTGPDTHTVHAWSSWEAYPMMAANAGSTTVRVPLTDCHHDLRA
                     MAAAVTDRTRMVLLCNPNNPTGTALRHERVRAFLDELPGHVTVVVDEAYRDFADPGAIA
                     DGIDLYRGDERVCVVRTFSKSYGLLSLRVGYLVGHDPVLAPIRAQLPFFRVSHVAQQAA
                     IAALGAHEKVLQGCADTARERDRLRRALLDQGWEVPVSQGNFLWLPMESGVERFTQFCA
                     DHAVVVCGKPGEGVRVTV"
ORIGIN
        1 tcaggccggc tgggccgctc cggtggaggg gggtgccatg acgccgccgc ggcgcagcac
       61 ggcgtagccg atgccgatgc ccacggccac cggccactcg atcacttcca cggcgcccag
      121 gacgcccagc cccacgtaga gggggaggcc gcccttggcg ggcagccacc ggcgggccac
      181 cgccaccggc agcagcgccg cgtccgccag gccgctcgcc acgcgccccg ccgtggggac
      241 ggtgacggtg aaggaccgct tgccgtcgcc ggacgacgtg gtcacgggcg gcttctcggc
      301 cttcgtcccg gccttcgcgg gggtggcggt ggccttctcg gaggccgtgg acttcgtcgc
      361 ggccgacttc tgccggcccg tcgtcttccg ctcggccgcc gtcttccggg ccgtcgcctt
      421 cgtcgccgtc ttcgtcttgt cggaggaccc gcgcttgcgg gaggtggtgg gagtactcac
      481 aggtctcacg tccgcacatg gtcgacgttg tggtaattcc tcacttttca gggtaatagg
      541 gatttatctt cgactggggt ggctgcgacg gggcggcggg gcagcgtgca gccgggcgat
      601 gggtagggag gccgcgccga tgtcacagtc ctcacggtca ggcgcatcag gcacgccggg
      661 ttcagcaggc acgtcgggca cgccggggag gccgggcata cgcatcccgg cgcccccgct
      721 gctgaagcca ctcgccggcg gggtgaccgc gggcgtgcgc ggcgcggccg gacttctcgg
      781 gcggctggcc aggctgccgc agcgcggggt gtggacccac ccgggacgcg tgtacatcga
      841 ggtccggggg gtgcacggca ccgggggcga gcgggtcgcc cgccgcgtgg agaccgcgct
      901 cgagacccac ccccgggtcc gctgggcgag ggtcaacgcg ccgtccgagc gcgtcgtggt
      961 ctccctcctc tcgcaggcgg tccgcgaggc cgagctgatc gccctggtcg agcaggggga
     1021 ggagtcagag gccgccgccg tggtcgagga gttcgacgag tggctcccgg agccccacca
     1081 cccctccgag ggacccagca cgcccgagtc cctctccgcg ctgaccgccg acgccgtggg
     1141 cctcaccctg gccacggcgc tgcggctggc cccctggctc aaactgccca ccgaggtcgg
     1201 cgcgctggcc tccctgctcc agcaccaccc ccggatacgc cggctggccg cggccatcgg
     1261 cggccccgac cggagcgact cggcgctgac cgccgtgagc gcgctggccc agggcgtggc
     1321 cacccgcggc ggagggctcg cgctggacgt ggtcgagcgc ctggcccagt ggcgggaggc
     1381 cgccgcggaa cgccaggcgt gggaggcggc ggagccgcac ctggtgcacg gcccccggga
     1441 cgtggaggcc gagccgatcg tcgtcgaacg ccccgccccg ccccccaggg acgccaccgc
     1501 gcgctacgcc gagcggtcca tgtggatcgg cgcggccgtc ggcgcgctcg ccgtaccctt
     1561 cgccggcccc cgccgcggcc tggccgtggc gctggcctcg atacccaagg cgccgggcgc
     1621 gggccgggag ggcttcgcca ccagcctcgg ccacttcctc gccctgcgcg gcgtggtggc
     1681 catggaccgc ggcgcgctgc gccggctggg ccaggtggac accgtggtgc tggacgagga
     1741 ggcgctgcgc ggcgaccggt acgagcccgt cgacgtggag gtgctcggcg gcgccgacgc
     1801 cccgcgggtc gccgagcggc tgttcgacct gttcgacccg gacgggcccc tggaggtccg
     1861 gaggaacggc cacggctggg cgctgggccc gctggaccgg ctcgacctga cgggccgtac
     1921 cggcggccag gccgcctccc gactgctccg caagggcagc gagcgcgtcc tcggcctggc
     1981 caggggccac cgcctccagg ccgtggtggg gctggccgcg cagaccgcgc ccggcgccga
     2041 ggccgtggcg gccgccgccc gcagggcggg cgcgcgggtc gtcctggcca ccgaccgccc
     2101 gcacccggcg ttcgccttcg ccgacgcggt ggtgcccgcc ggggggcgcc tggtggcctc
     2161 ggtgcgcgga ctccaggccg acggcgcggt ggtgctgctg ctgtccggca accgccgggc
     2221 cctgggcgcc gccgactgcg gcatcggcac ccaccgcgag ggcgaggccc cggcctgggg
     2281 agcgcatctg ctggtcggcg cggacctgga gtcggccgcg gtgatcgtgg acgccgtggg
     2341 cgtggcggcc cgggtcgacc gggacagcgc ggtgctcgcg gcgggcggca gcggcgtcgg
     2401 cgccgtcgcc gccctccagg cccaccgccg gcattcggcc gcgcgctcca ccggcgtcgg
     2461 caacaccgcc ggcaccatcg ccttctgcat gggcaactgg cgggcccggc agctgataac
     2521 ccgccccctg gcgccgccgg tgacctccgt cccctggcac ctgatgcccg cccggcgcgt
     2581 cctggaccgc ctcggcaccg cccccgaggg cctgaccccg gccgaggccg ccgcccgcgc
     2641 ccgcgccccc ggcggcccgc gcaccggcga gccgccccgc accagcctgc ccgcggcctt
     2701 catcgacgag ctcgccaacc ccctcacccc cgtgctcgcc gccggagccg cgctggccgc
     2761 cgccgtgggc tcgcgcaccg acgccgccct ggtggccgcc atcaccggca cctccgcgct
     2821 ggtcggcggc gtccagcggg tcaggaccga gcgcgccctg gcggagctgt tctcccgctc
     2881 ggccatcggc gcgcgggtgc gccgggccgg caccgagcgg ctggtcgccg ccggtgacct
     2941 ggtacccggc gacatcgtcg tgctgcgccc cgaggacgtg gtgcccgccg actgccggct
     3001 gctggaggcc gagggcctgg aggtcgacga gtcctcgctg accggcgagt ccctcccggt
     3061 ccccaaggac ccggcgccgg tgaccgccgg gcacatcacc gggcgccgct cgatgctcta
     3121 cgagggcacc accgtctccg ccgggcgggc ggtcgccgtc gtggtggcca ccggcacctc
     3181 caccgaggtc ggccgcagcc tcgccaccgc gcggcaggcc gcgcccgtca ccggggtgga
     3241 ggcccggctg accaagctca cccgggccag cctgcccatc gccctcggct ccgcgtccgc
     3301 cgtctccgcg gccgggctgc tgcacggccg caagctgacc gacaccctcg ctcagtcggt
     3361 gaacctcgcc gtcgcctccg tacccgaagg gctgcccttc ctggtcaacg cggcccagct
     3421 cgccgccgcc cgccggctgg ccgacctcgg cgcgctggtg cgcaaccccc gcaccatcga
     3481 ggcgctcggc cgcgccgacg tcctgtgctt cgacaagacc ggcaccctca ccgagggcac
     3541 cctccagctc gcggccgtcg gcgacgggga ccaccaactg cccgccgacc ggctcgacac
     3601 cccgcgcaag gccgtgctgg cggccgcgct gcgcgccacc ccgccggccc ggcaggccga
     3661 gcccatggcc caccagaccg accgcgccgt gatggccggg gcgcgccgcg ccggcgtcgc
     3721 ggtacgccag ggcgcccccc gctggcggcg caccgacgcc ctgcccttcg aaccgtcccg
     3781 ggcctaccac gccaccgccg ggcgcacctc ccacggcctg ctcctgagcg tgaagggcgc
     3841 gccggagaac gtgctgcgcc gctgcgccgg ccggcggcac agggacgcgc cggccccgct
     3901 ggacccggac gccgtcgagg agctcaccgc gcgcgccgag gagctggccg gcgcgggccg
     3961 ccgggtcctg gccgtggccg agcgccccat ggcggacgac gaggaactca ccgacgaggc
     4021 cgtacgggac ctggtcttcc tcggcttcgt cgccctggcc gacccggtcc gcaccagcgc
     4081 cgcccccgcc acccggcggc tgcacgaggc gggggtgcac acggtgatgc tcaccggcga
     4141 ccacccggcc accgcggacg ccatcgcggc gagagtcagc gacgtccccg agccgaaggt
     4201 gtgcaccggg cccgagctgg acgaactcga cgacgcggcg ctcgacgccc tgctccccac
     4261 ggtcgatgtg atcgcccgct gcagccccca ccacaaggtc cgcatcgtcc aggcgtacca
     4321 gcgcctcggg cgggtcgtgg cgatgaccgg cgacggggcc aacgacgcgc ccgccatccg
     4381 cctcgcggac gtcgggatcg ccctgggccg gcgcggcaca cccgccgcga ccgccgccgc
     4441 ggacctggtc gtcggcgacg accggctgga gacgatcgtc tcggcgctga tggagggccg
     4501 ggcgatgtgg gcctcggtgc gggccgcgct cgccatcctc atcggcggca acctgggaga
     4561 ggtcaccttc agcgtgctca ccgcctcgct caccggcggc accccgctga gcgcccggca
     4621 gatcatgctg gtcaacctgt tgaccgacct cgcgcccgcc ctcgccatcg cggtgcgcga
     4681 gccgaccggc cacaccggtg agcggctgct gcgggagggg ccgcacgtct ccctgggcac
     4741 cgccctcacc aacgagatgc tgctgcgggg cgggatcacc gccctcgggg ccggcctggc
     4801 ctggttcggc gcgcggctca ccgggcgacg gcgccgggcg tccaccgtcg cgctcgtcgc
     4861 cctggtcggc acccagctcg cccagaccct ggccaccggc ggcctggacc gccacgtcct
     4921 gatcgcgggg ctcggctccg ccgccgtcct cgcgggcatc gtccagacgc ccggcgtcag
     4981 ccacttcttc ggctgcaccc cgctgggccc cgtggcgtgg ggcatcacgc tgggctccat
     5041 cgccctggcc acgctgtccg gcgcggcgct gcccccgctg ctgcgcggcc tgccccgcta
     5101 gtgccccccg ggctcctcgt ccccgtccgg gatgccggcg agtgcgcgga agaaccggtc
     5161 ccggaagagc gggtccgtct cgccccgccg cagcgccgcg agatggtcct ccgagggcga
     5221 gagcctcgcg aacgccagat tggattcgta cggcggcgtc caccgccggt cgcgctcctc
     5281 ggcgtaccgc cgcagggcct tggccgtcag cccgggatcg tcgaccgcct ccgccaggca
     5341 cccggcgagc agctcggcct gggcgaacgc gtcgccgatc ccctgggcgc cgcacgggtc
     5401 cttgtggtgg cccgcgtccc cgaccagcgc ccaccccggg ccatgggccc ggcggaagaa
     5461 gttgcgcagg tccgtgcacc ggaacagccg gtcctcctgc cgggcggcgg ccagcggctc
     5521 cgccaggtcc gggcaggcgc gcagcgcgcc ggccagatag gcgcggggcg cgctctcccg
     5581 ggtcaggccc ggggtggcgc gggggagttg cacattgacc agcgtgaggc cgtcctgtgt
     5641 gggcaccagg gcggcgccgg cgccccgcgt cgagtacagc cccagcccgt ccccgggcag
     5701 tccgctccag tacgtgtaga gggcgacggt cagccggccg tcgtcgcgca ggtacggggc
     5761 gcccaccagc cgggccaccg tggagttccg cccgtcggcg cccaccacga gccgggcccg
     5821 ggcgcggtcc gcgccgccgc gcggcgtcgc gtaccggacc ccggccaccg ccccgccctc
     5881 ccacagcagc ccggtgaccg agcagccgtg gcggaactcc gcgccggccc gcgccgccgc
     5941 gcgggccagg atcgcgtcca gggcgtaccg ccggggcgcg aggccgccgg tggccgcgcc
     6001 ccacaccggc gccgggccgg tcagcaggag ccccggcgcc cggaaggaga tccgctccag
     6061 cggcggacag ccggtggccc ggacctcctc cagcacgccc caccgggcca ggcggtccac
     6121 gccgggctgg tggatgtaga gcgtggagag ggtgtcgctg gggaagcgcg cccgctccag
     6181 gacgaggacc cggtgcccct ggcgggcgag gagcagggcg gtggcggcgc cggcgcagcg
     6241 gccccccacc acgatcacgt cgtacatggg ctccccttcc ccgtggggcc cgacgccccg
     6301 catgtgtcac cgatagcacc gcgtgggggg acacgcccgg gcgacaggaa tagtcggccc
     6361 atgtggtcag aattccatat gactttccct tgggtatggg ttcactcttt gggatttccc
     6421 tgatccggaa cctcttgaca ggcttcgcgc ggccacattt tcatggcaca gggccgaaca
     6481 ccccgctgtc cggccccagt tcgggaagag accgtatccg tatccgatcg acaggagatt
     6541 cgccggtgat cgacaacgat ctgttcgagg aaatggccat tcaggagccg gaggcggtcg
     6601 tcgtctccac ctgcaccatc aagatggacg aggacatcga ggaaacccag tagcgccccg
     6661 gtgtttcccg gtctcccgac ccggggccgg gaaacacctc cgttctcgac cggcagttga
     6721 ctctcacttg agaaatggat ccgtgtgaac gcgcaaccgg gcacgccacc gagggaatcc
     6781 gtccggctcg tctcacggcg ggatgtgcgc cttgtcaacc gcgccggcca tgtctatatc
     6841 tgctccagca ccggcacgct gcgcgttccc cagcggaatc cggagctgag cgagctcgaa
     6901 ggcgacatcg gcctcgaatt cctccccgat gacgtcatcg cgggactgcg ctcccgcacc
     6961 ctggtgcact ccgcctccga cgccccgctc agccaccccc tgtacgacac gggcggcccg
     7021 gacgccaccc gcccggcggt ggtcgtcggc gagggcccgc tggccgacgg cgtcgccgag
     7081 cggctgcgcc gggccggggc ggaggccgtc cgggcccccg cccccgaccg gtcggcggat
     7141 ccgggagcgc tggtcctgcc cctgcacggg gacgaggccc tgctgcgccg gtggaccgag
     7201 cgggccatgg acgcccgggc accgatcctc acccatctgt cctcgcccac ccggctcctg
     7261 ttcgccgtcc tcgacccgcc gcgcaccgcc tgcccggtct gcctggtacg ccggctgcgc
     7321 gccaaccaca gctggcagcc catcgcggac ctgccgctcg acgtgctcta cggcgcggcc
     7381 gagagcgacc gctggcccac cacggccatc gccgcggcga tgctcgccca ccagaccatg
     7441 gcggccctca cccgtggccc gagcggcccg gccgagctgc tggaggtcga ccacgccacc
     7501 ctggtcacca cccgccaccc cgcgctccac accccgctgt gcccggcctg cgcccccgtg
     7561 gccgcgcccc cggagccggc cgagcccccg gccgtggacc cggagtcgtg ctgggagcgg
     7621 atgcgccggg cggtggaccc gctcaccggc ctggtggccg aggtccgggt gcgggacgcg
     7681 gaccgcgagc cgggcaactc gaccacgcat gtgctcaccg ccggacaccc cacgacgacc
     7741 tggttctccc cggtgcaggc gagctcgtgc agcggcgccg tcaagcacga cccgacactg
     7801 gcccgggtct gcgccgtggg ggagttcatg gagcgctacg cggccggggt ctacgacccg
     7861 gaccggctgg tccgcgcctc cttccggaag ctcggcgccg ccgccgtgga cccccggagc
     7921 ctgccgctgg cctccgagcg ggagtacgcc gcgctgtccc gcatcgcccc gttcgacccc
     7981 gacctggagc tcgactgggt ggagggccgc tcgctcacca cgggccggtc ccggtatgtg
     8041 cccgcctgcg cggtctacgt cccctaccgg ttcccgcgcc gccgggagcg gctgatcgac
     8101 cccatctcca ccggtctcgc ggccggaagc ggcccgcacc acgcgacgct cggcgggctg
     8161 ctggaggtcg tcgagcgcga cgccgccgcc gtcttctggg agaaccgcct cgcgctcccc
     8221 accctggacc tcggcgggct gaccggggga ccggccgccg cgatcgtcga gcggctgacc
     8281 gcggcgggcg tccaggtgct gtgcaaggac ctcaccaccg acctcggcat ccccgcggtc
     8341 tccgtccggt atgtcgaggg cccggcggac cggcccgtgg tggcccacgc caccagcgcc
     8401 cacctcgacc tccacggcgc cctgctcggg gcgctggagg aagccgacct gtgccggacc
     8461 gggctgcgga gctggctggc cgagcgggac atccccggtg tggacgacat cgagctcgac
     8521 cgatccgact tctacacgta ctactgcggc cccgggcggc tgtccctggt gccgttctgg
     8581 gacgagggcc cgctccgccc cctgccggcg ccttccccca cgcccgcctc ccaccaggcc
     8641 gcggtcgagg aggtggtccg gcggctggcc gcgcggggct acgagcccat cgccgtcgac
     8701 atcacaccgg tcgatgtggc ggagtgcggg gtgcgcgtgg tcaggagcgt cgtacccggg
     8761 ctgtgcccca tcaccctgcg gcgcgacttc cggcggcgcg gcggccggcg cctgtacgag
     8821 gcaccggtgc gcatgggcct gcgcgccgcc ccgctcaccg aggacgaact gaacccctat
     8881 ccgctgcccc tcggctgagc gcccgcgagg ggcggcccat ggcagcgaac gggacggcag
     8941 agcaggagaa gaacgccacg atgactcgtc agaccctgta ccggcgccgg cgggacacgc
     9001 tcgtcgaatg gggggagaac ggcaaactgg tgctggtgga ctgcggcgcc tggcggaagt
     9061 tcgccatcaa gccggagctg ctcgagctgc tctccctcct ggaccacccg cgcagcgccc
     9121 gggatgtgca cggcgcctgg gcgtcctcct cccgacccga ggacgaggtc cggcggctgc
     9181 tggagcggct ggccgaggcc gggatcgtat gccgggacgc ccccgaggac gacggacccg
     9241 cccccgaagc ggacgaggcg gaggcgcgcc gcgacggggc cggcgaggtg ccggggccgg
     9301 gcggggcgcc cccgggcgcc ggctggaccc cgtacgagct cgccgtgcac gcccaggcca
     9361 gccgctccgg cgtgccgacg cgcctgcgcg gcaccccgcc cgccgcccgg ctgctccacc
     9421 ccgaggccct ggagcggatc gagctgcccg aggacaccgc gccaccgagc cggcccctgg
     9481 accgggtcct ggccgaccgg cgctccatcc gcacgtacgc ccccagcccg gtgcccctgc
     9541 cgctgctggc cgccctcttc gcccgcaccg cccgggtgcg cggctacctc ccgccgctga
     9601 agtacgagca gacgcagcgc gccgcgccct ccggcggggc ccgccacagc ctggagctct
     9661 atctggtcgc ccgggaggtc gaggggctcg cgcccggcgc ctaccactac gacccgttcg
     9721 gccatgccct ggagcgcctc gcgccgtgga gcgaggagct ggacgacctc cagcggcgca
     9781 ccctgtgcgt gcccatgcag gaggaccagc ccccgccggc cggcctgtat ctcacctcct
     9841 gcgcgtatcg caccggttgg aagtaccagg gcatggcgct gagcctgatc taccgcgata
     9901 ccggctgcct gatgcagacc ctcagcctgg ccggcaccga catcggcctc gccacctgcc
     9961 tgaccggcag ggtcgagtcg cccatgaccc cctcgttcct gcggccctac cgggaccggc
    10021 tgatccatgt gggcaacatg gccatcgggc tgcccgcgcc catctccgcc gcgcaccgcc
    10081 tggtgcccct caccgccgac aaggagccgg agcgagcatg acccccgccg acagcgagcc
    10141 gccgccgctt cccacggtct gccgcacggc cgtatggacg gcacagatgc gggccgacga
    10201 gagccgtgtg ccaaacgctt gcgcggtcga tccctgggcc gccgagttcg tcgcggcggc
    10261 ggggccgcag ggcccgccgc cgggcggccc ggaggcccgg tccttcctcc acgacggggt
    10321 ggccgtgcgg acccggtact tcgacgacta cctcctggag gccgtggccg gcggatgctc
    10381 ccaggtcgtc ctgctcggcg cggggctcga cgcgcgggcc ttccggctgc cctggccccg
    10441 cccggtcgag gtcttcgagg tggacctgcc cgacctcctc gacttcaaga accgcgtggt
    10501 gggcggccgg gccccggccg ccgcgcgccg cgtcaccgtc gccgccgacc tgcgggacgc
    10561 gtgggccgag gccctgatcg ccgccgggtt cgacccggcg cggcgcacgg catggctctg
    10621 cgagggcacc ctggtctatc tggagcctgg tcaggccgac gcggtcgtgt gcaccatggc
    10681 cgcgcactcg cccccgggca gcgaggtcgg ggccgaaacc atgacgtccc agggccggct
    10741 ggactgcctg cgctcctgcc atgacgccct gtccgccgac ggagccccct ggcggtgctc
    10801 gctgagcgac cccgccgcgt ggtgggccga gcgcggctgg cgcatgacgg tccccgaccc
    10861 cgcgagcctg ccctacgccg ccgagcggat ggccccgtac ctgccgatgc tgcggcaggc
    10921 gggcgacgcg ggcggctggc tgctcacggg cacccggtgc gggcccggcc cggccgctcc
    10981 accggcgtag cctccgggcc cacgccggcg tcggccctcc ccggcgtcgg cctacgccgg
    11041 tgtcggggtg ggcctggcgt cggcctacgc cggccggacg cggcccgggg cgcggcgcgg
    11101 gctcgcgtcc ccgggaggcg ccggcggctc gccgccgggc ggcagcaggc agtcggtgga
    11161 ctcggccagc cggcccaccg ccgcccgcac cgcgcccatc agcgcggcca ccgccggcat
    11221 cttcgccgtc tccggccgca gcagcgcgta cacctggcgc cggggccagc ggttcagtcg
    11281 gcgcgcccgc acccgtggat cacgccgggg gagcaggccg agaccgtcca ggagggcgac
    11341 cccgaccccg tcgccgacca gcccgatggt cgtcgcctgg tcgtcggtgg tggtcaccac
    11401 ccgaggctcg aaccccgcct ccgcgcagcg ccgcagcaac cggccgcgct cccggcccag
    11461 gatccaccgc tcgccggaca gatcggcgag ggcgacgctg cgccgccgcg cgagggcgtg
    11521 cccgggcggc agcagcacat agcggcggtc ggcgagcagg ggcacccggc acagcgccgg
    11581 gtccgccgcc cccaccggtg accccggctc ccgggcgccc aggtcaccga ggtcgccgtc
    11641 gccgacgatc gcgacatcgg tctcacccga tcgcagcagg cggtacgagt ccggggacgc
    11701 ggcctggccc agctccacct ccacctcggt gctcgccgcg cgcatcaggg cgagcgcggc
    11761 gggcagcacc gcgacgcaca cgctctggac ggccgacacc cgcacccgcc cccgggtgtg
    11821 cgcggcgagc gcctcgaact cgctctccac ggcccgcagc ccggtcagca cctcctgggc
    11881 gcgctcggcg agccggtgtc ccgcgggcgt caaccgcacc ccgcggcccg acctggccac
    11941 cagcggcact ccggcggcgc gctccagggc gcgcatgtga tagctgacgg cgggttgggt
    12001 gtaaccgagc cggtcggcgg cggcgcggta ggagccggcg cgggagacct ctgcgagcac
    12061 ggtgagctgg cgaagatcca tcacccgaag gacgataaaa actcctgatg aatcgccgta
    12121 agactttaat tggacgtgtg atcaggtgac ggtcaaaatc atcgtgacgg ttcacccggc
    12181 ccccggccgg ccgtcctgcc cgaccggacc ccctcccccg gccccggacc acccacgcga
    12241 tcacggcccg cccgggccgg tttccccaag cggccgaagc ggcacgttcc gctccgccgg
    12301 aagtccaccc gcgggacccc gcgggtcact cgattgcccg cccgagcccc gcgcccgaat
    12361 cccccgccgg aatggatgga tggtgcccga tgcacgatgg ctggaaccgg atgcgccccg
    12421 tggtcgccga ggatcggccg ttccaccaga tggcgctgaa cgagaccgtt cacccgccgc
    12481 tccccgaagt gctggaggcg gtggcgcggg ccgggcggga ggcccaccgc acccatgacg
    12541 ccctcggcac cgccctgacc cgcgccctcg ccgaacacct cggggtggag ccggagcaca
    12601 tcctcgtcgg gcccggctcc ggcgcgctgc tccagcaact cttcaccacc cgcaccggcc
    12661 cggacaccca caccgtccac gcgtggtcct cctgggaggc ctacccgatg atggcggcca
    12721 acgccggatc caccacggtc cgggtgccgc tcaccgactg ccaccacgac ctgcgggcca
    12781 tggcggcggc cgtcaccgac cggacccgca tggtcctgct gtgcaacccc aacaatccca
    12841 ccggcaccgc gctgcgccac gagcgggtcc gggcgttcct cgacgagctg cccggccacg
    12901 tcacggtcgt cgtcgacgag gcgtaccgcg acttcgccga ccccggcgcc atcgccgacg
    12961 gcatcgacct gtaccgcggc gacgaacgcg tctgtgtggt gcgcaccttc tccaagtcct
    13021 acgggctgct cagcctgcgc gtgggatacc tggtggggca cgacccagtg ctcgccccga
    13081 tccgcgccca actgccgttc ttccgggtga gccatgtcgc ccagcaggcc gcgatcgccg
    13141 ccctcggcgc ccacgagaag gtgctccagg ggtgcgcgga caccgcccgt gagcgcgacc
    13201 ggctgcgccg cgcgctgctc gaccagggct gggaggtgcc ggtgagccag ggcaacttcc
    13261 tgtggctgcc gatggagtcc ggggtcgagc gcttcaccca gttctgcgcg gaccacgcgg
    13321 tggtcgtctg cggcaagccg ggagaggggg tgcgggtgac cgtggccgag cccgaggcca
    13381 tcgaggcgtt caggcaactg gccgcgaaat accgggagtc gaggtaa
//
