LOCUS       BGC0002591             20232 bp    DNA     linear   BCT 02-MAY-2017
DEFINITION  Streptomyces sp. strain NA04227 aurachin biosynthetic gene cluster,
            complete sequence.
ACCESSION   BGC0002591
VERSION     BGC0002591
KEYWORDS    .
SOURCE      Streptomyces sp
  ORGANISM  Streptomyces sp.
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 18:03:24
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1485)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 417.6; E-value:
                     8.3e-127)"
                     /gene_kind="transport"
                     /note="Orf-2"
                     /product="multidrug resistance protein"
                     /protein_id="ARM20253.1"
                     /transl_table=11
                     /translation="MNQRQRWTLLAVSIAAFMLLLDLTIVTVALTDIQESLEASFDDLQ
                     WVVDAYALTLAAFLLTAGTLADRMGRRKVFLIGLIVFTLSSLGCGLAWSPEALLVFRGL
                     QGVGGAVLLAAGPSLLAQEFALGAERNKAFAAFGGSAGLAIAAGPLVGGALTSIDWRWI
                     FLINLPVGLLCLYVVLTKLRDERDAAAQPVDWIGAVLLCAGLFLVTYGLMRGEADGWTS
                     GRILGCLLLSVAILGAFVLWQSRTTAPLMDLRLFANPSFSGLAVATLLAYAALFPALFF
                     STLFLQRVQSYSAFDTGVRMLPLTIAMFIASALAAPLAAKISPRLLMTVGLALTGGGLL
                     LLTGLEADKSWTQLLAGFIVCGFGAGVFNVVRSEATVSLVPPSRSGEASGVGSTFQEVG
                     VAFGIAVLGSLFHNQVVADAEATGVPEGAVQDAAMSINTFTDALDDVFLWGGIIALAAA
                     LLILVTFRHTPQPPASGTGSGAGSATGDKSDLPAAS"
     source          1..20232
                     /country="China: Qixia Mountain, Nanjing"
                     /db_xref="taxon:1931"
                     /host="Forficula auricularia (earwig)"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp."
                     /strain="NA04227"
     misc_feature    1..20232
                     /note="aurachin biosynthetic gene cluster"
     protocluster    1..20232
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[11923:14516]"
                     /cutoff="5000"
                     /detection_rule="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /neighbourhood="20000"
                     /product="HR-T2PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      11924..14516
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /neighbourhood="20000"
                     /product="HR-T2PKS"
                     /protocluster_number="1"
     cand_cluster    1..20232
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="neighbouring"
                     /product="HR-T2PKS"
                     /product="terpene"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..20232
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002591"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..20232
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="HR-T2PKS"
                     /product="terpene"
                     /region_number="1"
                     /rules="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..19437
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[8312:9437]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      8313..9437
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="2"
     cand_cluster    1..19437
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="2"
                     /tool="antismash"
     CDS             complement(2355..3170)
                     /codon_start=1
                     /note="Orf-1"
                     /product="hypothetical protein"
                     /protein_id="ARM20254.1"
                     /transl_table=11
                     /translation="MTGESAPRGAAGSASPPTAGSAVSPPVHSGQTRVLDHLVYATPEL
                     AATVEEFAERTGVRPAPGGVHPGLGTRNHLVDLGEGRYLEIIGPDPEAPEPRRPRPFGI
                     DELTGPRLVTWALCPVDLDATVGGARSAGYDPGPVVPMSRTTAEGATLNWRLAGLTGQE
                     PPGLVPFLIDWGTSPHPTSAPGLPRLTLEGLQLHAMAPGLTLGRLSALGALTVPEESAA
                     GATTGVAATGVATTGPVLVEVFAVAGEEGPRENRLECTLTTPRGILTFG"
     CDS             complement(3167..4504)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 273.9; E-value: 3.6e-83)"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome P450"
                     /product="SauP1"
                     /protein_id="ARM20255.1"
                     /sec_met_domain="p450 (E-value: 2.5e-23, bitscore: 72.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDSLNAPAPDTWPGYDPSDPVFRADPYPTYRRLRAAGPLARGFL
                     DSPAFVRFQDCERLLHDTRLGKDFAKSSLYEAVLAQTDGNPPPFLGFGIEGGSKPFMLV
                     DPPEHTRLRGLVAGAFTESLTQRMPAAVQAAVDAQLDAVSAEFGAKFGTGTGAEFDAEF
                     DGEFDGEFDAVRSIAEPLPVRIMADLLGIPEADRETFAALGAGISGVLELDVTLSEEAA
                     EARRGAIRACMASFESLTAARRANPGEDLISALTLAGDGRDRLTDLEVATTSLLMMAAG
                     LDTTATLIASCVWVLARHPEAYARLVADPSLAPSAVTEVLRFEPPAPEMGRIALEDFTY
                     EGHEFKKGEALLLVLGSANRDERRFPDGDRFVIDRDDPGHLAFGSHIHRCLGAPLAELA
                     AARVLQGLAARFETLTLAVDPPPIKEGFVLRGPSALPVTVTRGGRA"
     CDS             complement(4899..6050)
                     /codon_start=1
                     /note="HMBDP synthase; MEP pathway"
                     /product="SauM2"
                     /protein_id="ARM20256.1"
                     /transl_table=11
                     /translation="MSVPLGIPQLPAPVLAPRRRTRQLDVGGVGVGSESPVAVQSMTVT
                     TTSDVNATLQEIAQLTAAGCDIVRVACPSQDDADALPQIARKAQIPVIADIHFQPRYVF
                     AAIEAGCAAVRVNPGNIKKFDDQVKEISQAARETGTPIRIGVNAGSLDKRLLQKHGKAT
                     PEALVESALWEAGLFAEHDFHDIKISVKHNDPVVMVRAYELLAESCDYPLHLGVTEAGP
                     AFQGTIKSAVAFGALLRQGIGDTIRVSLSAPPVEEVKVGLQILQSLNLRPRKLDIVSCP
                     ACGRAQVDVYKLADEVTAGLEGLEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIF
                     VKGEVIKTVPESKIVETLIEEALRIAEENGLEPGEPEVVPVSG"
     CDS             complement(6182..8110)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110:1-deoxy-D-xylulose-5-phosphate synthase (Score:
                     253.5; E-value: 3.3e-77)"
                     /gene_kind="biosynthetic-additional"
                     /note="DXP synthase; MEP pathway"
                     /product="SauM3"
                     /protein_id="ARM20257.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 2.2e-112,
                     bitscore: 364.7, seeds: 174, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQSLQAIKGPADLKALSLAETAELAQDIREFLIDKVSRTGGHLGP
                     NLGVVELTLALHRVFDSPRDTLLWDTGHQTYVHKIVTGRADGFDQLRQPGGLSGYPSRA
                     ESEHDVIENSHASTVLSYADGLAKAHQLRGVTDRAVVAVIGDGALTGGMAWEALNNIAA
                     AKDRPLVVVVNDNERSYSPTIGGLADHLARLRTRPGYEKFLAGVKERVPGVPVVGRPLY
                     GALHGAKKGLKDLVAPQGMFEDLGLKYLGPVDGHDQEALEDVLRVAAGFDGPVLVHAIT
                     QKGRGYGAAEQDEAERFHVVRAQPKGKPAPKPAYPSWTSVFGEEMIELAEDREDLVAIT
                     AAMLGPVGLVEFARRHPARIFDVGIAEQHAATSAAGLALGGLHPVVAVYATFLNRAFDQ
                     LLMDVALHKAPVTFVLDRAGVTGDDGPSHNGMWDMSLLQVVPGLRLAAPRDGARLRELL
                     GEAVAVDDGPTVLRFPKGTTGPDIEAVAHEDGIDVLRRDARQDVLLVSVGALAGTCLET
                     AERLAAEGHGVTVVDPRWVKPVPRRLVELAAEYRLVATVEDNGRVGGVGSALAQTLGDH
                     GVHTPVRVFGISQEFLDHGKRPQILAESGLDAAQLTAALQAQLTALSGAATIAQQRAVL
                     AAKQLAG"
     CDS             complement(8313..9437)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: NapT7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 219.9; E-value:
                     6.7e-67)"
                     /gene_kind="biosynthetic"
                     /note="trans-isoprenyl diphosphate synthase"
                     /product="SauI"
                     /protein_id="ARM20258.1"
                     /sec_met_domain="NapT7 (E-value: 3e-124, bitscore: 404.2,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAGRSVTENTATTAAQGAVATDTTAGATPRELRERLLDDAERA
                     IGGLLDRETERWRAEAPQSLALFDGIRDLVTAGGKRLRPAFCVSGFLAAGGDPAEPVLP
                     GLAAALELMHVSALLHDDIFDEADLRRGRPTSHLVQAERHRAAGWRGSSQRFGESVAIL
                     AGDLAAVYADQALRDARGPVLDEWSLLRSEMMVGQFMDLSIAAEYNPDPELSRRVALYK
                     SGRYSIHRPLNIGALFAGREDLAEPFEVYGRALGEAFQLRDDLIDAFGEDSVTGKTAGL
                     DFAQHKMTLLLGLAMQSDERVRELVRRGEGGVDRSDVAELRRLIVDAGIRDQVEKHIDE
                     LVLTAVAALDTADVSEAWRSELTVMAHRVAYRDS"
     CDS             complement(9613..10374)
                     /NRPS_PKS="Domain: Thioesterase (18-230). E-value: 5.7e-19.
                     Score: 61.3. Matches aSDomain:
                     nrpspksdomains_ARM20259.1_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004:thioesterase (Score: 104.3; E-value: 8.9e-32)"
                     /gene_kind="biosynthetic-additional"
                     /note="thioesterase"
                     /product="SauT"
                     /protein_id="ARM20259.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 8.7e-10, bitscore:
                     29.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAGAERVVLKKGSPEGLRLICVPFAGGSARSFARLATMVGEDWS
                     VVAVQPPRSHGDGERDLDALAHFYLGLLAEDLRGPGLLFGHSLGAAVVHRMAQLWSSHW
                     PKDLHVVLSAPPAPEFTSAGLYGLDDQMLFEVATEQGILPALGVSEDMVKRLMLPDLRA
                     DLAVLAKRGWTATPLKAPVHLMGGERDLPSPPAVLEQYREILQAVSLRLLQAGHMYVLE
                     QPAETAEALLAIGASVGKTPVAAQAGRRADA"
     aSDomain        complement(9685..10320)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ARM20259.1_Thioesterase.1"
                     /evalue="5.70E-19"
                     /label="ARM20259.1_Thioesterase.1"
                     /locus_tag="ARM20259.1"
                     /protein_end="230"
                     /protein_start="18"
                     /score="61.3"
                     /tool="antismash"
                     /translation="RLICVPFAGGSARSFARLATMVGEDWSVVAVQPPRSHGDGERDLD
                     ALAHFYLGLLAEDLRGPGLLFGHSLGAAVVHRMAQLWSSHWPKDLHVVLSAPPAPEFTS
                     AGLYGLDDQMLFEVATEQGILPALGVSEDMVKRLMLPDLRADLAVLAKRGWTATPLKAP
                     VHLMGGERDLPSPPAVLEQYREILQAVSLRLLQAGHMYVLEQPAETAEA"
     CDS_motif       complement(10078..10140)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ARM20259.1_0001"
                     /evalue="1.40E-05"
                     /label="NRPS-te1"
                     /locus_tag="ARM20259.1"
                     /protein_end="99"
                     /protein_start="78"
                     /score="17.6"
                     /tool="antismash"
                     /translation="GPGLLFGHSLGAAVVHRMAQL"
     CDS             complement(10371..11927)
                     /NRPS_PKS="Domain: AMP-binding (26-418). E-value: 3.2e-88.
                     Score: 287.9. Matches aSDomain:
                     nrpspksdomains_ARM20260.1_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     337.8; E-value: 1.5e-102)"
                     /gene_kind="biosynthetic-additional"
                     /note="anthranilate-Coa ligase"
                     /product="SauE"
                     /protein_id="ARM20260.1"
                     /sec_met_domain="AMP-binding (E-value: 8.4e-91, bitscore:
                     294.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSETAAPTTGQGNAALWYLDRHLGLDTADAVALITEEGELTYRQL
                     HERVCKAARVLADSGLGPGDRMVTVLPDGVLPVALVLAAMRLGAVPVPVSPLLTAEEQR
                     YIVEDSGAVVVVHDDPAGEVAADFAERFPRAVLLTARPGGERPLPELVDAASPLWEAVA
                     RDGEDMAVIQYTSGSTGRPKGVVHLHRGLLAFPQGIGAHLGIGRADRVLSTAKLPFGYG
                     FGNSLLLPFAVGASAILFRGRAEPHLVADLVQRHRPTVLFAVPTLYAAMLTLAGTGRRP
                     DLSGVRLAVSAGEHLGALLGERFEEAYGLTLVNGLGSTECLHIFLATVAGVSPHGVTGV
                     PVPGFEVQVCDEEDRVLPAGEMGHLRVRGPSTGARYLGLSELSAQTFRDGWVYTGDTLV
                     DDPEGGWMYLGRSDSILNVGGLKILPSEIEDVINALEGVAGCAVVGVRDENEITRIVAH
                     VVPRDPDDAGLRRTVIDAAREQLPVFKRPQTVRVVEELPVTSTGKTARHLIRRREMEKQ
                     S"
     aSDomain        complement(10674..11849)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ARM20260.1_AMP-binding.1"
                     /evalue="3.20E-88"
                     /label="ARM20260.1_AMP-binding.1"
                     /locus_tag="ARM20260.1"
                     /protein_end="418"
                     /protein_start="26"
                     /score="287.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="TADAVALITEEGELTYRQLHERVCKAARVLADSGLGPGDRMVTVL
                     PDGVLPVALVLAAMRLGAVPVPVSPLLTAEEQRYIVEDSGAVVVVHDDPAGEVAADFAE
                     RFPRAVLLTARPGGERPLPELVDAASPLWEAVARDGEDMAVIQYTSGSTGRPKGVVHLH
                     RGLLAFPQGIGAHLGIGRADRVLSTAKLPFGYGFGNSLLLPFAVGASAILFRGRAEPHL
                     VADLVQRHRPTVLFAVPTLYAAMLTLAGTGRRPDLSGVRLAVSAGEHLGALLGERFEEA
                     YGLTLVNGLGSTECLHIFLATVAGVSPHGVTGVPVPGFEVQVCDEEDRVLPAGEMGHLR
                     VRGPSTGARYLGLSELSAQTFRDGWVYTGDTLVDDPEGGWMYLGRSDSILNV"
     CDS_motif       complement(10767..10856)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ARM20260.1_0002"
                     /evalue="8.30E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="ARM20260.1"
                     /protein_end="387"
                     /protein_start="357"
                     /score="11.9"
                     /tool="antismash"
                     /translation="PAGEMGHLRVRGPSTGARYLGLSELSAQTF"
     CDS_motif       complement(11361..11420)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ARM20260.1_0001"
                     /evalue="6.10E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ARM20260.1"
                     /protein_end="189"
                     /protein_start="169"
                     /score="25.0"
                     /tool="antismash"
                     /translation="AVIQYTSGSTGRPKGVVHLH"
     CDS             complement(11924..13210)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     HR-T2PKS: ketoacyl-synt"
                     /gene_kind="biosynthetic"
                     /note="beta ketoacyl synthase"
                     /product="SauD"
                     /protein_id="ARM20261.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.7e-16, bitscore:
                     50.5, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTASSPTPPTTGVAVTAVGAVTAAGTTVAALFDDMLAARAHRTET
                     VIPLVANPLPVPAGQDDGSRPVTAAHVTDPLDLTEAVGARAARALSRDSRLLMRAMDAT
                     GISAAPAPDTTAVVLGTLGAGRNEYLAIHRASGTTHRPVNPVWGPQSGYNAAAAQLSIH
                     LKAYGPNLTLSSGATSGLDAVVTGAEYIADGRCEAVVAAGMDTLSAAVDSTATPAKGAV
                     PAGEAAAVLVLRPAPVEDALAYVRGAGQTTALTSGASRTGTAGAGADLDGAQPSRVTED
                     FESVDPTEAADAQELTEAARAALREALEQAGRTASAIGLVVLASSGDRAVVRAEQAAVS
                     AELGADVPTCNPTATTGRTGGADGSLAVVVAVEALRRGVVPSPGGARIDGPLALCLCLD
                     RGGSVTAVLVESAGAVGAESTGADLAGAA"
     CDS             complement(13299..14516)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (85-400). E-value:
                     2e-47. Score: 153.9. Matches aSDomain:
                     nrpspksdomains_ARM20262.1_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     HR-T2PKS: hr-t2pks-ksa"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 348.3; E-value:
                     1.1e-105)"
                     /gene_kind="biosynthetic"
                     /note="beta ketoacyl synthase"
                     /product="SauC"
                     /protein_id="ARM20262.1"
                     /sec_met_domain="hr-t2pks-ksa (E-value: 3.1e-104, bitscore:
                     339.0, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPDAGASPRVVVTGMGCVTPLGTEIDEFWAKLTSGAVATEEVTR
                     FDTSGYPTRLAAEIKDPRLAGPLDEHGHDVPRCVRYVNHAAEAALRDAKLLDQSDTRRT
                     GVLLGTVMGTRPHVEEVRRRGREFGSGEDWDNPGLLALAPARAFGLRGPREVVAAGCAA
                     GNTALSMAADRIRSGRADVMLAGGADELSEAVFRLFTTLRALAPDQVRPFDRERQGMLP
                     GEGAGILVLESEDHALRRGATILAELSGYAVGADAHHMTAPHPEGRGMLACMRDSLAMA
                     GLTPGDVDYVSAHGTGTPANDALEAAVTQAYFGPSGARPAVSSVKGMLGHAQGGASAVE
                     AIACVRAIRDGRVPGNPTLREPDEKCAELDIVRGTHRDMPVNVALSNAFGFGGNTSTVV
                     FGRYES"
     aSDomain        complement(13317..14261)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ARM20262.1_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.00E-47"
                     /label="ARM20262.1_PKS_KS.1"
                     /locus_tag="ARM20262.1"
                     /protein_end="400"
                     /protein_start="85"
                     /score="153.9"
                     /tool="antismash"
                     /translation="AEAALRDAKLLDQSDTRRTGVLLGTVMGTRPHVEEVRRRGREFGS
                     GEDWDNPGLLALAPARAFGLRGPREVVAAGCAAGNTALSMAADRIRSGRADVMLAGGAD
                     ELSEAVFRLFTTLRALAPDQVRPFDRERQGMLPGEGAGILVLESEDHALRRGATILAEL
                     SGYAVGADAHHMTAPHPEGRGMLACMRDSLAMAGLTPGDVDYVSAHGTGTPANDALEAA
                     VTQAYFGPSGARPAVSSVKGMLGHAQGGASAVEAIACVRAIRDGRVPGNPTLREPDEKC
                     AELDIVRGTHRDMPVNVALSNAFGFGGNTSTVVF"
     CDS             complement(14506..14745)
                     /NRPS_PKS="Domain: PP-binding (9-72). E-value: 6.4e-11.
                     Score: 34.6. Matches aSDomain:
                     nrpspksdomains_ARM20263.1_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="ACP"
                     /product="SauB"
                     /protein_id="ARM20263.1"
                     /sec_met_domain="PP-binding (E-value: 1.7e-11, bitscore:
                     34.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDESEITYGVREVIAQVLSLSVDEVSPTAHFYDELAGDSLQKLEA
                     IAFIEAKFNVQLTNEEAAGETVGDLVRSVVGHAS"
     aSDomain        complement(14530..14718)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ARM20263.1_PP-binding.1"
                     /evalue="6.40E-11"
                     /label="ARM20263.1_PP-binding.1"
                     /locus_tag="ARM20263.1"
                     /protein_end="72"
                     /protein_start="9"
                     /score="34.6"
                     /tool="antismash"
                     /translation="VREVIAQVLSLSVDEVSPTAHFYDELAGDSLQKLEAIAFIEAKFN
                     VQLTNEEAAGETVGDLVR"
     CDS             complement(14849..15907)
                     /codon_start=1
                     /note="prenyltransferase"
                     /product="SauA"
                     /protein_id="ARM20264.1"
                     /transl_table=11
                     /translation="MTAGAQVDAARRRPGLGRSALFLARSCSVRFAAYYWCGFMVGFAI
                     NDSLSLGWALGAIPLWLAYCIGTESVNRIADREADLVNRPERTHLVQEFGWGRMKAACV
                     IAWLVFAAGGAVMLWQEPSPVLAAVLVLDVFIAICYSIGPAFKRRRVLSVIALITPLIM
                     PMVTGWAVHGDLDSLLSPTLPAAAVLAAFSVGLSGIKDITDVEGDEKLDYSSLWIALMG
                     SRSGARVYALVGAPFVVLTAFTSFGQLPWQALLVFPLVAVSTLVVVAAAKADEPEDRGA
                     AREVMHQYTFYFLVLFLAAAVPGTATALVAVIGIGYWLFASRLLHWSGGLTLRHLRLWW
                     GLFSTTRQPAVR"
     CDS             complement(15907..17193)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 367.4; E-value:
                     1.4e-111)"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome P450"
                     /product="SauP2"
                     /protein_id="ARM20265.1"
                     /sec_met_domain="p450 (E-value: 1e-16, bitscore: 50.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQTHSAPEVPADGPAPGGVSFDPTDPGLQQNPYPAYAFLRENLP
                     VMRGPLGVWMVSRYEDCEALLRDRRMGKDFANSKFFEQIMGSSEELPPFLGFGLDDFDA
                     KMFLLTDPPEHTKLRGLVSQAFTPAIINAMRPRIASIVDELLGELPAEFDLMERLATPM
                     PIRVLGSMLGIPEADQEQFTSWSVQIAGMLDLDVELPPEVAATRRAATGACTTYFLELA
                     ERRAAEGGQGEDLISHLVRARDEGSALSTQEIAATCVLLVVAAQETFSNLIGNSGMVFA
                     RHPEAFTGLAADPDSIDGVINEIMRLEPPAHQVGRIALEKFDLHGEVFEPGDAVILLVA
                     AANRDERAFPEPDTFRADRDGRPNLSFGRGIHYCLGAPLANLMAREALTGLTRRITSVQ
                     LTQETIDFKPGLGLRGPAKLPVRVERRGS"
     CDS             complement(17767..18861)
                     /codon_start=1
                     /note="regulator"
                     /product="SauR"
                     /protein_id="ARM20266.1"
                     /transl_table=11
                     /translation="MDVMDVVEDVRVPLRWAGGRPAPRAFPLSDVQLVPVAAVLSADSP
                     RQEAENLEHALTLAESAAELPPIVVHRPTMRVIDGTHRLRVARLRGRGEIEARFFDGPE
                     EDAFVLAVQTNIGHGLPLSLAERTAAAARIIVSHPQWSDRAIAQVTGISHKTVAVQRRK
                     IGGEAVQPLSRIGCDGKERPVSSAEGRRLASRLIAAHPQASLRDIAARAGISAGTVRDV
                     RARLGRGEDPVPQRRGGGSRKASEQAVSEESQALPPGPEGPETRGVRRAAAADTGARER
                     ESTFRSLCRDPSLRQTNSGRLLLRMLEMHVTQTQRWDRVAEAVPAHRAAAIAEMAAECA
                     RQWQALAARASASAKTPERLSAAG"
     CDS             19795..20232
                     /codon_start=1
                     /note="Orf+1"
                     /product="hypothetical protein"
                     /protein_id="ARM20267.1"
                     /transl_table=11
                     /translation="MGRPEAHIDPSEGPLQRFAHDLRAVRHKAGSPSYESLASRANYSG
                     TTLAAAARGIQLPSLEVTLAYVSACDANPQPWVAYWNRTRAALAQHAQDRTRQRPPQRR
                     VSTAGTTTSRPVRRVGGGDRPDRSERSDHAGRERRDQFAGA"
ORIGIN
        1 tcaggaagcc gcgggcagat ccgatttgtc gcccgtcgcg gacccggcac cggaccccgt
       61 gcccgaagca gggggctgcg gggtgtggcg gaaggtgacg aggatcagca gggcggcggc
      121 gagggcgatg atgccgcccc agaggaagac gtcgtccagg gcgtcggtga aggtgttgat
      181 gctcatcgcc gcgtcctgta ccgcgccctc ggggacgccg gtcgcctccg cgtcggcgac
      241 cacctggttg tggaagaggg agccgagcac ggcgatgccg aaggcgacgc cgacctcctg
      301 gaaggtgctg ccgacacccg aggcctcgcc ggagcgggac ggcgggacga gcgagacggt
      361 ggcctcggag cggaccacgt tgaagacgcc ggcgccgaag ccgcagacga tgaagcccgc
      421 gaggagctgt gtccaggact tgtcggcttc caggccggta aggagcagca gtccgccgcc
      481 ggtcagggcg aggccgacgg tcatgagcag ccggggcgag atcttcgcgg ccagcggggc
      541 cgcgagcgcc gaggcgatga acatcgcgat ggtcagcggg agcatccgga cgccggtgtc
      601 gaacgccgag tagctctgga cacgttggag gaacagggtc gagaagaaca gggccgggaa
      661 gagggcggcg taggcgagca gggtggccac cgcgaggccg ctgaagctgg ggttcgcgaa
      721 gagccgcagg tccatcagcg gggcggtggt ccggctctgc cacaggacga aggcgccgag
      781 gatcgcgacc gagagcagca ggcagccgag gatacggccg gaggtccagc cgtccgcctc
      841 gccgcgcatc agcccgtagg tgaccaggaa cagtccggcg cagagcagta cggcgccgat
      901 ccagtccacc ggctgggccg ccgcgtcgcg ctcgtcccgc agcttggtga gcaccacgta
      961 caggcacagc aggccgacgg ggaggttgat caggaagatc cagcgccagt cgatgctggt
     1021 gagcgcgccg ccgaccagcg ggcccgccgc gatggccaga ccggccgagc caccgaaggc
     1081 cgcgaacgcc ttgttgcgct cggcgccgag cgcgaactcc tgggcgagca gggacggtcc
     1141 ggccgcgagc agcaccgctc cgccgacgcc ctggaggccg cggaagacca gcagcgcttc
     1201 gggcgaccag gccaggccgc agcccagcga gctgagcgtg aacacgatca ggccgatcag
     1261 gaacaccttg cggcggccca tccggtcggc gagggtgccc gcggtcagca ggaaggccgc
     1321 gagggtcagc gcgtaggcgt cgacgaccca ctggaggtcg tcgaaggagg cctcgagcga
     1381 ctcctggatg tccgtgagcg cgacggtgac gatggtcagg tccagcagca gcatgaacgc
     1441 tgcgatggac acggccagca gagtccagcg ctggcgttgg ttcatggggg cgttgtccct
     1501 tcaggggccg gtttggggac cggtgcttcg cggttcggtg cgatgcgatg ccgagcggtg
     1561 gcatgcgagg cgatgcgatg ccgagcggtg ccatgcggta cggcgcagtg cgttgccgtg
     1621 cggtgcaatg cggtgcagtg ccgtgcgagc agtgcggcgc gatgaggtgc gaggggggcg
     1681 cgtcgcaatg cggttgagat gccgtacgaa gtcgcctcgg ggcggcatcg gccgggggag
     1741 gcaccgtaga gggcgctccc gttgccgtcc ggtcggccgg tatctgcggt gccctcccca
     1801 ctcggtcctc cgcactcgac acccgacacc cggcactcgg cactcggcac tcggggacgt
     1861 ggtggcagcg agagttggga gggggcaggc ccctacattg ccgcgcacga gggggccagg
     1921 gcgacattct tcgctgcggc acatccgcaa aaatgttccc gcactttcgg cacggacccc
     1981 ggaaacggtt ccgacagcga ggaaggatcc agcccaccaa cagccctcac cacagggcct
     2041 attgagcgga cagcaggaca acttgaacga gtaggcgacg ccccgtttcc accgcactgt
     2101 cgacctcgac ccgatagccc cggcaggttc gagcaactcg gaatccgacc gcccgatttg
     2161 ctcatgctag cgacgcccga cgtgagcctg caatgcattg tgcaactggg gatatcgccc
     2221 tgaatggggt ggtacgggat cgtcggccgt ctacttcgac tcactccgcc agcggttcca
     2281 tgacacggca actgctctct tacggcaagg cgttgcaccg aaatcggctg gagagcgccg
     2341 gggccggccg caggtcagcc gaaggtgagt attccccggg gtgtggtgag ggtgcactcc
     2401 agtcggttct ccctgggccc ctcctccccc gccaccgcga agacctccac cagcaccggc
     2461 cccgtggtgg ctacccccgt ggcagccacc cccgtggtgg ccccggcggc cgactcctca
     2521 ggcaccgtca gagcgcccag cgcggagaga cgccccagcg tcaaccccgg tgccatcgcg
     2581 tgaagttgga gcccctcaag agtcaggcgc ggcagcccgg gcgccgacgt gggatgaggg
     2641 ctggtccccc agtcgatgag gaacgggaca aggccgggcg gctcctggcc ggtgagtccg
     2701 gcgagccgcc agttcagggt ggcgccctcg gccgtggtgc gcgacatcgg gacgacgggg
     2761 cccgggtcgt acccggcgga ccgcgccccg ccgaccgtgg cgtccaggtc cacggggcac
     2821 agtgcccagg tcaccaggcg gggcccggtc aactcgtcga tgccgaaggg gcgggggcgt
     2881 cgcggctccg gggcctcggg gtcggggccg atgatctcca ggtagcggcc ctcgcccagg
     2941 tcgaccaggt ggttacgggt gccgagcccc gggtggacgc cgccgggggc gggacgtacc
     3001 cccgtacgct cggcgaactc ctcgacagtg gccgcgagtt cgggcgtcgc gtagacgagg
     3061 tggtccagta cgcgggtctg cccgctgtgc acaggcgggg agacggcgga cccggcggtc
     3121 ggaggcgatg cggacccggc cgccccgcgc ggtgcggact cgcccgtcat gcgcgccctc
     3181 cccgcgtcac ggtgaccggc agcgcgctcg ggccgcgcag tacgaagccc tcctttatgg
     3241 gcgggggatc gacggccagc gtcagggtct cgaagcgggc ggcgaggccc tggaggacgc
     3301 gggcggcggc gagttcggcc aggggggcgc cgaggcagcg gtggatgtgg gagccgaagg
     3361 cgaggtggcc ggggtcgtcg cggtcgatca cgaagcggtc gccgtcgggg aagcgccgct
     3421 cgtcgcggtt ggcggagccg aggacgagca gcagtgcctc gcccttcttg aactcgtggc
     3481 cctcgtaggt gaagtcctcc agggcgatac ggcccatctc cggtgcgggc ggctcgaagc
     3541 ggaggacctc ggtgacggcg ctcggggcga gtgaggggtc ggcgacaagg cgcgcgtacg
     3601 cctcggggtg gcgggcgagt acccagacgc aggaggcgat cagggtggcc gtggtgtcca
     3661 ggcccgcggc catcatcagc aggctggtgg tggcgacttc gaggtcggtg agccggtccc
     3721 ggccgtcgcc cgcgagggtc agcgcggaga tcaggtcctc gcccgggttc gcgcggcggg
     3781 ccgcggtcag ggactcgaac gaggccatgc acgcgcggat cgcgccgcgc cgtgcctcgg
     3841 cggcctcctc ggacagcgtg acgtcgagtt cgaggacccc ggagatgccc gcgccgagtg
     3901 cggcgaaggt ctcccggtcc gcctcgggta tgccgagcag gtccgccatg atgcgtacgg
     3961 gcaggggctc ggcgatgctg cgtaccgcat cgaactcccc gtcgaactcc ccgtcgaact
     4021 ccgcgtcgaa ctccgcgccc gtccccgtac cgaacttcgc gccgaactcg gcactgacag
     4081 cgtcgagttg ggcgtcgacg gcggcctgga ccgcggcggg catccgctgg gtcagggact
     4141 cggtgaaggc tccggcgacc aggccgcgca ggcgggtgtg ctcgggcggg tcgaccagca
     4201 tgaagggctt gctgccgccc tcgatgccga agccgaggaa cggcggcggg ttgccgtccg
     4261 tctgcgccaa caccgcttcg tagagggagg acttggcgaa gtccttgccc aggcgggtgt
     4321 cgtgcagcag ccgttcgcag tcctggaagc ggacgaacgc gggcgaatcg aggaagccgc
     4381 gggcgagtgg acccgccgcg cgcagccgcc ggtaggtcgg atagggatcc gcacggaaga
     4441 ccgggtcgct cgggtcgtag ccgggccagg tgtccggcgc gggcgcgttc aggctgtctg
     4501 tcacgtgtga tccccgtttg tctctgtacc gcatacggca gttggcggca cacgccgaac
     4561 gggaggaccc gggcgacgcc tgccaaggcg gcctgggccg tcggccgccc ggcgcacgcg
     4621 tacgggcatc agaaacccgc gtgccgcgtg gtcggtcggc cagggcggcc cgggtggcaa
     4681 cgaaggcatg cgcgacggcc gccaggggcg cctgcccggt cacagtggaa cgggagtcga
     4741 ggatacggat tacccgccca tgactgaaga ccgtgcagaa atccctttcg cggtaaggga
     4801 gttcgtacgt acgggtaact cgccgggtaa cccgctgcgg acggtgggcg cggtggacgg
     4861 tgggcgaccc ggccacggtg ggagacccgc ccgccccctc agccggaaac cggcaccacc
     4921 tccggctccc ccggctccag cccgttctcc tccgcgatgc gcagggcctc ctcgatcagg
     4981 gtctccacga tcttcgactc ggggacggtc ttgatgacct cgcccttgac gaagatctgg
     5041 cccttgccgt ttccggaggc gacgccgagg tcggcctcgc gggcctcgcc gggaccgttg
     5101 accacacagc ccatcaccgc gacgcgcagc gggacttcga ggccttcgag tccggcggtg
     5161 acctcgtcgg ccagtttgta gacgtcgacc tgggcgcggc cgcaggcggg gcaggagacg
     5221 atgtccagct tgcgggggcg caggttgagg ctctgcagga tctgcaggcc gaccttgacc
     5281 tcttcgaccg gcggcgcgga cagcgagacg cggatggtgt cgccgatgcc ctggcgcagc
     5341 agcgcgccga aggcgacggc ggacttgatg gtgccctgga aggcgggacc ggcctcggtg
     5401 acgccgaggt gcagggggta gtcgcaggac tcggcgagca gttcgtaggc gcggaccatg
     5461 accaccgggt cgttgtgctt gaccgagatc ttgatgtcgt ggaagtcgtg ctcggcgaac
     5521 aggcccgcct cccacagcgc cgattcgacc agggcctccg gggtggcctt gccgtgcttc
     5581 tggagcagcc gcttgtcgag ggagcccgcg ttgacgccga tccggatcgg ggtgccggtc
     5641 tcccgggccg cctgcgagat ctccttgacc tggtcgtcga acttcttgat gttgcccggg
     5701 ttgacgcgta cggccgcgca gcccgcctcg atggcggcga acacgtagcg gggctggaag
     5761 tggatgtcgg cgatgacggg gatctgggcc ttgcgcgcga tctggggcag ggcgtccgcg
     5821 tcgtcctggg aggggcaggc cacccggacg atgtcgcaac cggcggcggt gagctgggcg
     5881 atctcctgca aggtggcgtt gacgtccgag gtggtggtga ccgtcatgga ctgcacggcc
     5941 accggcgact cactgcccac gccgacgccg ccgacgtcga gttggcgggt cctgcgccgc
     6001 ggggcgagta cgggcgcggg cagctggggt atcccgagcg ggaccgacat ggctgttcct
     6061 ccggagggtc ggggcggccc ggatggaccg ctgcgggtgc cggggcggag ccggtacggc
     6121 gacgggcaga gccggtacgg cgacggccgg gcgccgccgt accggtctca aaccgcccgg
     6181 cctaccccgc gagctgcttg gccgccagga ccgcgcgctg ctgggcgatg gtggccgcgc
     6241 cgctcagggc ggtgagctgt gcctggagcg cggccgtcaa ctgcgcggcg tccaggccgc
     6301 tttcggcgag gatctgcggg cgcttgccgt ggtccaggaa ctcctggctg atgccgaaca
     6361 cgcgcaccgg ggtgtgcaca ccgtggtcgc cgagggtctg cgccagggcc gaaccgacgc
     6421 cgcccacacg gccgttgtcc tcgacggtgg ccaccaggcg gtactcggcg gcgagttcga
     6481 caaggcgccg cggtacgggc ttgacccagc gcgggtcgac gacggtgacg ccgtggccct
     6541 cggcggcgag ccgctcggcc gtctccaggc aggttccggc gagggcgccg accgagacga
     6601 gcaggacgtc ctggcgtgcg tcgcggcgca gtacgtcgat gccgtcctcg tgtgccacgg
     6661 cctcgatgtc ggggccggtg gtgcccttgg ggaagcggag cacggtgggg ccgtcgtcga
     6721 cggcgaccgc ctcgccgagc agttcgcgca gccgggcgcc gtcgcgcggg gcggcgagcc
     6781 tgaggcccgg tacgacctgg agcagcgaca tgtcccacat gccgttgtgg gaggggccgt
     6841 cgtcgccggt gaccccggcc cggtccagga cgaaggtgac cggagccttg tgcagggcga
     6901 cgtccatcag gagctggtcg aaggcgcggt tgaggaaggt ggcgtagacg gcgacgaccg
     6961 ggtgcagtcc gccgagggcc aggcccgccg ccgaggtcgc cgcgtgctgc tcggcgatgc
     7021 cgacgtcgaa gatgcgcgcg gggtggcggc gggcgaactc gacgagcccg accgggccga
     7081 gcatggcggc ggtgatggcc accaagtcct cgcggtcttc ggcgagttcg atcatctcct
     7141 cgccgaagac ggaggtccag gaggggtacg cgggcttcgg cgcgggcttg cccttcggct
     7201 gggcgcgcac cacgtggaag cgctccgcct cgtcctgttc ggccgccccg tagccgcggc
     7261 ccttctgggt gatggcgtgg acgagcaccg ggccgtcgaa tccggcggcc acccgcagca
     7321 cgtcctccag tgcctcctgg tcgtggccgt cgaccgggcc caggtacttc aggcccaggt
     7381 cctcgaacat gccctgcggg gcgaccaggt ccttcaggcc cttcttcgcg ccgtgcagcg
     7441 ccccgtacag cggcctgccg acgaccggca ccccgggcac ccgctccttg accccggcca
     7501 ggaacttctc gtagccgggg cgggtgcgca gccgggccag gtggtcggcg aggccgccga
     7561 tggtgggcga gtaggagcgc tcgttgtcgt tgacgacgac gacaaggggg cggtccttgg
     7621 cggcggcgat gttgttcagc gcctcccagg ccataccgcc ggtgagggcg ccgtcgccga
     7681 tgaccgcgac cacggcgcgg tcggtgacgc cccggagctg atgcgccttc gcgaggccgt
     7741 cggcgtagga gaggaccgtg gaggcgtggc tgttctcgat gacgtcgtgc tcggactcgg
     7801 cgcggctcgg gtagccggac aggccgccgg gctggcgcag ttggtcgaag ccgtcggcgc
     7861 ggccggtgac gatcttgtgg acgtaggtct ggtggccggt gtcccacagg agggtgtcgc
     7921 ggggcgagtc gaagacccgg tgcagggcga gcgtcagctc gaccacgccg aggttggggc
     7981 ccaggtgtcc gccggtgcgg ctgaccttgt cgatgaggaa ctcgcgtatg tcctgggcga
     8041 gttcggccgt ctcggcgagg gagagggcct tgaggtccgc ggggcccttg atcgcttgca
     8101 gtgactgcat cgcgccttct tccgtctcgt tgcgactcgt tacggctcgt tccggcttac
     8161 gggctcgtct cgttgcggcg gctcgttctc gttgcggctc gtacggctcg ctgcggcttg
     8221 gtacgactgg gtacggctcg gtacgacttg gtccggctcg gggaaacgct ccggccgcgg
     8281 ccctcgcggg cgcgcggccg gagcggggtg gctcaggagt cgcggtaggc gacgcggtgg
     8341 gccatcacgg tcagttcgct gcgccaggcc tcggacacgt cggcggtgtc gagcgcggcc
     8401 acggcggtca gcaccaactc gtcgatgtgc ttctccactt ggtcgcggat cccggcgtcg
     8461 acgatcagcc ggcgcagttc ggcgacgtcc gagcggtcca cgccgccctc gccgcgccgg
     8521 accagttcgc gcacccgctc gtcgctctgc atggcgagcc cgagcagcag ggtcatcttg
     8581 tgctgggcga agtcgagtcc ggccgtcttg ccggtgacgg agtcctcgcc gaaggcgtcg
     8641 atcaggtcgt cgcgcaactg gaaggcctcg ccgagcgcgc gcccgtacac ctcgaagggc
     8701 tcggccaggt cctcgcgtcc ggcgaacaac gccccgatgt tcaggggccg gtggatggag
     8761 taacggcccg acttgtacag ggcgacgcga cgggacagct ccgggtccgg gttgtactcg
     8821 gcggcgatgg acaggtccat gaactggccg accatcatct ccgagcgcag cagcgaccac
     8881 tcgtcgagca cggggccgcg ggcgtcgcgc agcgcctggt cggcgtagac cgcggcgagg
     8941 tcaccggcga ggatcgccac gctctcgccg aaccgctggg agctgccgcg ccagcccgcc
     9001 gcgcggtgcc gctcggcctg caccagatgc gaggtcgggc ggccccggcg cagatcggcc
     9061 tcgtcgaaga tgtcgtcgtg caacagggcc gagacatgca tgagttcgag ggcggcggcc
     9121 aggcccggca ggacgggttc ggccgggtcg ccgcccgccg cgaggaaacc ggagacgcag
     9181 aacgcgggcc gcagccgctt gccgcccgcg gtgaccaggt cgcgaatccc gtcgaaaagg
     9241 gcgaggctct gcggcgcttc ggcgcgccag cgctccgtct cgcggtccag gagcccgccg
     9301 atggcgcgct cggcgtcgtc gaggagccgc tcgcgcagtt cccgcggggt ggccccggcg
     9361 gtggtgtcgg tggccacggc gccctgggcg gccgtggtgg cggtgttctc ggtgacggac
     9421 ctgccggcgg tgctcatggt gactcctgct cgttccgact gacggccccg gacggttcgc
     9481 gtccggggcc ctgaagctgc ggccgcccga gggcggccgg caagtgtgtg cacgggcacg
     9541 cggaggggct gtgcaactgg gcgtagttcc cactcgcccg gcccgtccgc gcgcccgccg
     9601 cgcgtgtggc gtttacgcgt ccgcgcgtcg gcccgcctgt gcggcgacgg gggtcttccc
     9661 gacgctcgca ccgatggcga gcagggcctc ggcggtctcc gcgggctgct cgaggacgta
     9721 catgtgaccg gcctgaagca gtcgcaggga caccgcctga agtatctcgc ggtactgctc
     9781 gaggacggcc ggaggactgg gcaggtcccg ctcgccgccc atcaggtgga cgggcgcctt
     9841 cagcggggtc gccgtccagc cgcgcttggc gaggaccgcg aggtccgcgc gcaggtccgg
     9901 cagcatgagc cgcttgacca tgtcctcgga gacgccgagc gcgggcagga tgccctgctc
     9961 ggtggccacc tcgaacagca tctggtcgtc gagcccgtac aggcccgccg aggtgaactc
    10021 cggcgcgggc ggcgccgaga ggaccacgtg caggtccttc ggccagtgcg aggaccagag
    10081 ctgggccatg cggtgcacga ccgccgcgcc caggctgtgc ccgaagagca gacccgggcc
    10141 cctcaggtcc tcggcgagca ggccgagata gaagtgcgcg agcgcgtcca ggtcacgctc
    10201 gccgtcgccg tgggaacgcg gtggctgtac ggccaccacg ctccagtcct ctccgaccat
    10261 ggtggcgagc cgcgcgaacg acctcgccga accacccgca aacggcacac agatcagccg
    10321 cagcccctcg gggctgccct tcttcagtac gacacgttcc gcgccggccc tcacgattgc
    10381 ttctccattt ctcgccgcct gatcaggtgg cgggcagttt ttccggtgga ggtcacgggc
    10441 agttcctcga ccacccgtac cgtctgaggt cttttgaaca cgggcagttg ctcgcgggcc
    10501 gcgtcgatga cagtgcggcg cagcccggcg tcgtccgggt cccggggcac gacatgggcg
    10561 acgatgcggg tgatctcgtt ctcgtcccgc acgccgacga cagcgcaacc ggcaaccccc
    10621 tcaagggcgt tgatgacgtc ctcgatctcg ctcggcagga tcttgagccc cccgacgttc
    10681 aggatgctgt cggacctgcc caggtacatc cagccgcctt ccgggtcgtc gacgagtgtg
    10741 tcgccggtgt acacccagcc gtcacggaag gtctgcgcgc tgagctcgga aagccccagg
    10801 tagcgggcgc cggtgctcgg cccgcgcacc cgcagatggc ccatctcgcc cgccgggagc
    10861 acccggtcct cctcgtcgca gacctgcacc tcgaagcccg gtacgggcac gccggtcacg
    10921 ccgtgcggcg agacgcccgc gaccgtggcc aggaagatgt gcaggcactc ggtggagccg
    10981 aggccgttga ccagggtcag gccgtacgcc tcctcgaagc gttcgccgag cagggcgccg
    11041 aggtgctcac cggcggagac cgccaggcgc accccggaca ggtcgggccg ccgtccggta
    11101 ccagccaggg tgagcatcgc cgcgtacagg gtgggcaccg cgaacagcac cgtgggccgg
    11161 tgccgttgca ccaggtcggc gaccaggtgc ggttcggcgc ggccgcggaa gaggatcgcc
    11221 gaggcgccga ccgcgaaggg cagcagcagc gagttgccga agccgtagcc gaagggcagc
    11281 ttcgcggtgg acaggacccg gtccgcgcgg ccgatgccca ggtgcgcgcc gatgccctgc
    11341 gggaaggcga gcagcccgcg gtgcagatgc acgactccct tcgggcgccc ggtggatccg
    11401 gaggtgtact gaatcaccgc catgtcctcc ccgtcgcgcg cgaccgcctc ccacaacggg
    11461 cttgcggcat cgacgagttc gggcagcggg cgctcaccgc cggggcgggc ggtgagcagt
    11521 acggcacgcg ggaagcgctc ggcgaagtcg gcggcgacct cgcccgccgg atcgtcgtgg
    11581 acgaccacaa ccgccccgga gtcctcgacg atgtagcgct gttcctcggc cgtgagcagc
    11641 ggagagaccg gcaccggcac cgcgccgagc cgcatcgcgg caagcacgag ggcgaccggc
    11701 agcacgccgt ccggcagcac ggtgaccatg cggtcgccgg gcccgagacc actgtcggcg
    11761 agcacgcggg cggccttgca cacacgctcg tgcagctgcc ggtaggtgag ttcgccctcc
    11821 tcggtgatca gcgcgacggc gtcggcggtg tccaggccga ggtggcggtc caggtaccag
    11881 agggcggcgt tgccctgccc ggtggtgggt gcggcagtct cgctcacgcc gcacccgcca
    11941 ggtccgcgcc agtgctctcg gctcctacgg cccccgcgct ctccacgagt acggcggtga
    12001 cgctgccacc ccggtccagg cacaggcaca gcgccagcgg gccgtcgatc cgcgcgccac
    12061 cgggtgacgg gaccactcca cgccgcagcg cctccacggc gacgacgacg gcgagcgagc
    12121 cgtccgcgcc gccggtgcgg ccggtcgtcg cggtggggtt gcaggtgggt acgtccgcgc
    12181 ccaactcggc ggatacggcg gcctgttcgg cgcgtacgac ggcccggtcc ccgctggagg
    12241 cgagcaccac gaggccgatc gcggaggccg tgcgcccggc ctgctccagg gcttcgcgga
    12301 gtgcggcgcg tgcggcctcg gtcaactcct gggcgtcggc ggcctcggtg gggtcgacgg
    12361 actcgaagtc ctcggtgacg cgcgagggtt gcgcgccgtc gaggtccgct ccggccccgg
    12421 ccgtcccggt ccgcgaagca ccgctcgtca gcgcggtggt ctgccccgcc ccgcgtacgt
    12481 aggcgagcgc gtcctcgacc ggagcgggac gcagcaccag tacggcggcc gcctcgcccg
    12541 cgggtacggc gcccttcgcc ggggtggccg tcgagtcgac ggcggccgag agggtgtcca
    12601 ttccggcggc gacgaccgcc tcgcacctcc cgtcggcgat gtactcggcg ccggtcacca
    12661 ccgcgtcgag ccccgaggtc gcgcccgagg agagggtgag gttgggcccg tacgccttga
    12721 ggtggatgga gagttgggcc gccgccgcgt tgtagccgga ctgcggtccc cagaccgggt
    12781 tgacggggcg gtgggtggtg ccggaggcgc ggtggatggc caggtactcg ttgcggcccg
    12841 cgccgagggt gccgaggacg acggcggtgg tgtcgggggc gggggccgcg gagatgcccg
    12901 tggcgtccat ggcgcgcatg agcaggcggc tgtcgcggct cagggcgcgg gcggcgcggg
    12961 cgccgaccgc ctccgtcagg tcgagcgggt cggtgacatg ggcggcggtc accgggcggc
    13021 tgccgtcgtc ctggcccgcg gggaccggca gcgggttggc gacgaggggg atcacggtct
    13081 cggtgcggtg ggcgcgcgcg gcgagcatgt cgtcgaagag cgcggccacc gtggtcccgg
    13141 cggcggtcac cgcgccgacg gcggtgacgg cgacgccggt cgtcggtggc gtcgggcttg
    13201 atgcagtcac ttcggttccc tgtggtgtgt ggcggccccg gccgccgcgc ggagcgacag
    13261 tggtgtcggc gcgcggcggc ccgggccggg tgcggaggtc aggactcgta ccggccgaag
    13321 acgaccgtcg aggtgttgcc tccgaagccg aaggcgttgc tcagcgcgac gttcaccggc
    13381 atgtcgcggt gggtgccgcg cacgatgtcc aactcggcgc acttctcgtc gggttcacgc
    13441 agggtcggat tgccgggcac ccggccgtcg cggatggcgc ggacgcaggc gatggcctcc
    13501 accgcgctcg ccccgccctg cgcgtgaccg agcatcccct tcaccgagga cacggccgga
    13561 cgggcacccg aagggccgaa gtacgcctgg gtgacggccg cttcgagcgc gtcgttggcc
    13621 ggggtgccgg tgccgtgcgc gctgacgtag tcgacgtctc cgggcgtgag cccggccatg
    13681 gcgaggctgt cccgcataca ggcgagcatg ccgcggccct cggggtgcgg ggcggtcatg
    13741 tggtgggcgt cggcgcccac cgcgtaaccg ctgagctcgg cgaggatggt ggccccgcgg
    13801 cgcagggcgt ggtcctcgga ctccaggacg aggatgcccg cgccctcgcc cggcagcatg
    13861 ccctgccgct cccggtcgaa gggccgcacc tggtccggtg ccagcgcccg caaggtggtg
    13921 aacagccgga agacggcctc ggagagttcg tccgcgccac ccgcgagcat gacgtcggcg
    13981 cggcccgagc ggatccggtc tgcggccatg gacaacgcgg tgttcccggc cgcgcagccc
    14041 gccgccacga cctcgcgcgg tccgcggagc ccgaaggcac gcgcgggcgc gagggcgagc
    14101 agtcccggat tgtcccagtc ctcgccggag ccgaactccc gtccacggcg ccgtacttcc
    14161 tcgacgtgcg ggcgggtgcc catcacggtg ccgagcagta cgccggtgcg gcgggtgtcg
    14221 ctctggtcga gcagtttcgc gtcgcgcagc gcggcctcgg ccgcgtggtt gacgtagcgg
    14281 acacagcgcg gcacgtcgtg gccgtgctcg tccagcggac cggccagccg ggggtccttg
    14341 atctcggcgg ccagccgcgt ggggtagccg ctggtgtcga agcgggtgac ctcttcggtc
    14401 gcgaccgctc cggaggtcaa cttcgcccag aactcgtcga tttccgtgcc gagcggggtg
    14461 acacagccca tcccggtcac cacgactcgg ggggacgcgc ccgcgtcagg atgcatggcc
    14521 gaccacgctc cgtaccaggt cgccgacggt ctccccggcg gcttcctcat tggtcaactg
    14581 gacgttgaac ttggcctcga tgaacgcgat cgcctccagt ttctgcagcg agtcgcccgc
    14641 gagttcgtcg tagaagtgcg cggtgggcga cacctcgtcg acgctcaggc tcagtacctg
    14701 ggcgatgacc tcccgcacgc cgtacgtgat ctccgactcg tccatgctct tctccgttgg
    14761 ggttggggcc cgagggccgg gggtgctgtg cggatggccg ggcggcggct cgggccgggt
    14821 ggccccctcc gccgtacggc cgggccggct accggacggc cggttgccgg gtagtgctga
    14881 acaggcccca ccagagcctg agatgacgca gcgtcagtcc gcccgaccag tgcagcagcc
    14941 gggacgcgaa cagccagtag ccgataccga tgacggcgac cagggcggtg gccgtgccgg
    15001 gcacggcggc cgcgaggaac agcaccagga agtagaaggt gtactggtgc atcacctcgc
    15061 gcgcggcgcc gcggtcctcg ggctcgtcgg ccttcgccgc ggccaccacg accagcgtcg
    15121 agacggccac cagcgggaag accagcagtg cctgccacgg gagctggccg aaggacgtga
    15181 acgcggtgag gacgacgaag ggggcgccga ccagggcgta cacccgtgca ccgctcctgc
    15241 tgcccatcag cgcgatccac aggctggagt agtcgagctt ctcgtccccc tcgacatcgg
    15301 tgatgtcctt gatgccggac aggccgacgc tgaacgcggc gagtacggcc gcggcgggca
    15361 gcgtgggcga gagcagcgag tccaggtcgc cgtggaccgc ccagccggtg accatcggca
    15421 tgatcagcgg agtgatcagg gcgatcacgg acagcacccg gcgccgcttg aaggccggac
    15481 cgatcgagta gcagatggcg atgaagacat cgagcacgag cacggcggcc agcacggggc
    15541 tcggctcctg ccagagcatc accgcgcccc cggcggcgaa caccagccag gcgatcacac
    15601 aggccgcctt catccgtccc cagccgaact cctgcaccag atgagtgcgt tcgggccggt
    15661 tgacgaggtc ggcctcgcgg tcggcgatcc ggttcaccga ctcggtaccg atgcagtacg
    15721 cgagccacag cgggatcgcc ccgagcgccc agccgagact gagcgagtcg ttgatcgcga
    15781 acccgaccat gaagccgcac cagtagtacg cggcgaagcg cacactgcaa ctgcgggcca
    15841 ggaacagcgc ggacctgccg aggcccggcc gccgccgcgc cgcgtccacc tgtgcccccg
    15901 cggtcatcag gacccccgcc tctccacccg gaccggcagc ttcgcgggtc cgcgcaggcc
    15961 gaggcccggc ttgaagtcga tggtctcctg cgtgagttgg accgaggtga tgcgccgggt
    16021 gaggccggtc agcgcctccc gtgccatcag gttggccagc ggggcgccca ggcagtagtg
    16081 gataccgcgg ccgaaggaga ggttcgggcg gccgtcgcgg tcggcgcgga aggtgtccgg
    16141 ctcggggaag gcgcgctcgt cgcggttggc ggcggccacc aggaggatca cggcgtcacc
    16201 gggctcgaag acctcgccgt gcaggtcgaa cttctccagg gctatccggc cgacctggtg
    16261 ggcgggcggc tccaggcgca tgatctcgtt gatcacgccg tcgatgctgt ccgggtcggc
    16321 ggcgaggccc gtgaacgcct ccgggtgacg cgcgaagacc atgccggagt tgccgatcag
    16381 gttggagaag gtctcctgcg cggcgaccac cagcagcaca caggtcgcgg cgatctcctg
    16441 ggtgctgagc gcgctgccct cgtcgcgggc gcgcaccagg tgcgagatca ggtcctcgcc
    16501 ctgtccgccc tcggcggcgc gccgctcggc cagttcgagg aagtacgtgg tgcaggcacc
    16561 ggtcgccgca cgacgggtcg cggccacctc gggcggcagc tccacgtcca ggtcgagcat
    16621 gcccgcgatc tgcaccgacc agctggtgaa ctgctcctgg tcggcctcgg ggatgccgag
    16681 catcgagccg agcacgcgta tcggcatcgg cgtggcgaga cgctccatca ggtcgaactc
    16741 cgccgggagt tcaccgagca gctcgtccac gatcgatgcg atccgcggcc gcatcgcgtt
    16801 gatgatggcg ggcgtgaagg cctgcgagac caggccgcgc agcttggtgt gctccggcgg
    16861 gtcggtgagc aggaacatct tggcgtcgaa gtcgtcgagc ccgaagccga ggaacggcgg
    16921 cagctcctcg gaggagccca tgatctgctc gaagaacttg gagttggcga agtccttgcc
    16981 catccgccgg tcccgcagca gcgcttcgca gtcctcgtag cggctgacca tccacacccc
    17041 gagcgggccg cgcatcaccg gcaggttctc gcgtaggaac gcgtacgcgg ggtacggatt
    17101 ctgctggagc cccgggtccg tcgggtcgaa ggagacgccg ccgggggcgg ggccgtcggc
    17161 tggaacctcg ggtgcgctgt gggtctggct cattgcggaa ctctctttcc ggcgaagggc
    17221 cctggggcct tgccgaggat ccggggctgt gtggaacccg cggagtcggg cggatgtcgt
    17281 gctgcttgcc attgccggtg cgggtacggc ggtgccgtta cgggctgccg ctgcttcggc
    17341 gatgtggtcc ggtaccgggt cgggtggtgc gctcggacgt gggctcgggc gggtgcctga
    17401 ggtgcgtcac gcggtcgact gctacgacgt acctcatccc tcatccgtaa ccgatcggcg
    17461 gtgcctgctc ttcgctgtct gacgcggcga ctgggccgcg agttgtgcgg tggactgcta
    17521 tgcgttgtgt gacgctcaaa ggtgcgtgcg cggttcagtc cgcggttatc gaatatggcc
    17581 gtatcggctt gtgtttgtca gttcagtttt cgggttcgga ttccggtgcc gcaattgctc
    17641 cgattccgac gtctcggggc tttcggcagg ggtgcggacc gcttccacgg gccccggccc
    17701 gccgtatgcg cccggcttcc cgggtacggg ccgtggccgc ggaagtccgc cgggccggcg
    17761 ggcggttcag cccgcggcgc tcaaccgctc cggtgtcttg gcggaggccg acgcccgcgc
    17821 ggcgagggcc tgccactgcc gcgcgcactc cgccgccatc tcggcgatcg ccgcggcccg
    17881 gtgcgcgggc accgcctcgg cgacccggtc ccagcgctgg gtctgggtca cgtgcatctc
    17941 cagcatccgc agcagcagac ggccgctgtt cgtctgccgc agcgaggggt cacggcacag
    18001 actgcggaac gtcgactccc gctcgcgcgc gcccgtatcg gccgccgctg cccgccggac
    18061 gccccgggtc tccgggccct ccggccccgg cggcagcgcc tgcgactcct cggaaacagc
    18121 ctgttcagag gccttccggc tgccgccgcc gcgacgctgc ggtacggggt cctcgccacg
    18181 gccgagacgg gcgcgtacgt cgcgtacggt gcccgcggag atcccggccc gcgccgcgat
    18241 gtcgcgcagc gaggcctgcg gatgcgcggc gatcagccga ctcgccaggc ggcggccctc
    18301 cgcgctgctg accggacgct ccttgccgtc gcagccgatc cgcgacagcg gctgcaccgc
    18361 ctcgccgccg atcttgcgcc gctgtaccgc gacggtcttg tgcgagatcc cggtgacctg
    18421 ggcgatcgcc cggtccgacc actgcgggtg ggacacgatg atccgtgccg ccgcggccgt
    18481 gcgctcggcg agcgagagcg gcagcccgtg cccgatgttg gtctgcactg cgaggacgaa
    18541 ggcgtcctcc tcgggcccgt cgaagaaccg cgcctcgatc tcaccgcgcc cgcgcagccg
    18601 cgcgacccgc agccggtgcg taccgtcgat gaccctcatg gtcggccggt gcaccacgat
    18661 gggcggcagt tccgccgccg actcggcgag cgtcagcgcg tgttccaggt tctcggcctc
    18721 ctgccgcggc gaatccgcgg aaagcacggc ggccaccgga acgagctgca catcggagag
    18781 cggaaaggcc cgtggtgcgg gacggccgcc cgcccaacgc aacgggacac gcacatcctc
    18841 gacgacatcc atgacgtcca tgacatccat tagttgactc ccccgaatca atggacttca
    18901 cccagccgga ataccgaatt ccgtactctc ccccacacct cggaaactgt acgcaatgac
    18961 accccggctc cgcacgggcg cgtgcccgag cctgtagccg accactaaag caccactaaa
    19021 accgcaggtc agggcgctgg acacggaagg gttcgcacgt tcgagcctgc cgtccacaac
    19081 cgacaccgag gcgacggcga agcgacggcg gcacgacggc aaaaccgcgg cggggctgcg
    19141 gcggggccaa cagcggcgag acagcgggcc ggccggagaa cggcccgccg ttgaccggcg
    19201 gaccgtcggc gagcgagaac cggcagtgga cgagaaccag ccacgggcga ccaggggtaa
    19261 cccgggccaa cccgggggca attccgagat tcgagcgtca tcgaatccct ccccctcaac
    19321 attccgggca ccgatatgcc ttcaccccgc aaagcacata agcacgacag gggacacgga
    19381 agacacatcc ggcacaacgg aattcccact ccccaaaatc gcgcacaaag acacataccg
    19441 aaccaccgcc gccaccccca acgcccccac ccggaagccc ggttgaacca ctctccgtgg
    19501 cgacctcggc acttttctgc aactcgcgta gaccctatgt cgcatttacc ctcctatgac
    19561 gcccctcctc tccctgcgtt gaaaaaagat gagcgtggcg tgacagaggg gtgcactgca
    19621 tggtggaagg gacgacgaac gcgccacggg cgattgccga cgtcccaccg agcgcggcgc
    19681 gcggccggac cgtattcagg aacggatccg cccccaaagg cgccctcgat tgcgcggcaa
    19741 cacaccctcg gcgcgcggta acacctgagg acatatgggg agttgatacc ggcgatggga
    19801 agaccagaag cacacatcga cccgtccgag ggaccgctgc agcgcttcgc gcacgacctg
    19861 cgagccgtac ggcacaaggc aggcagcccc tcgtacgagt cactggcgag ccgcgcgaac
    19921 tactcgggca ccacactggc cgccgccgcc cgcggcatcc agctcccgag cctggaggtc
    19981 accctcgcct acgtgagcgc ctgcgacgcc aacccgcagc catgggtggc ctattggaac
    20041 cgcacccgcg cggccctggc ccagcacgca caggaccgca cccgccaacg gccgccgcag
    20101 cgcagggtgt cgacggccgg tacgacgacg tcacgccccg tcaggcgagt gggcggcggc
    20161 gaccgcccgg accgctccga acggtccgac catgccggac gcgagcggag ggatcagttc
    20221 gcgggggcgt ga
//
