BGC0002598 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002598 (Aspergillus westerdijkiae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	27,735	ochratoxin A	PKS	100%

BGC0002598 - Region 1 - NRPS,T1PKS

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Location: 1 - 27,735 nt. (total: 27,735 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 27,736
Label		BGC0002598

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002598	2.00	Polyketide	ochratoxin A	Aspergillus westerdijkiae
BGC0002607	1.35	NRP, Polyketide	ochratoxin A	Aspergillus westerdijkiae
BGC0002608	1.03	NRP, Polyketide	ochratoxin A	Aspergillus steynii
BGC0001030	1.01	NRP, Polyketide	ochratoxin A	Penicillium nordicum
BGC0002605	0.91	NRP, Polyketide	ochratoxin A	Aspergillus carbonarius
BGC0002606	0.75	NRP, Polyketide	ochratoxin A	Aspergillus niger
BGC0002610	0.63	Terpene	stellatic acid	Aspergillus stellatus
BGC0002155	0.60	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0002525	0.59	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0002191	0.58	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002598	1.00	Polyketide	ochratoxin A	Aspergillus westerdijkiae
BGC0002607	0.88	NRP, Polyketide	ochratoxin A	Aspergillus westerdijkiae
BGC0002608	0.79	NRP, Polyketide	ochratoxin A	Aspergillus steynii
BGC0001030	0.79	NRP, Polyketide	ochratoxin A	Penicillium nordicum
BGC0002605	0.76	NRP, Polyketide	ochratoxin A	Aspergillus carbonarius
BGC0002606	0.70	NRP, Polyketide	ochratoxin A	Aspergillus niger
BGC0002610	0.65	Terpene	stellatic acid	Aspergillus stellatus
BGC0002155	0.64	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0002525	0.63	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0002191	0.63	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 27735:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val) + (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

oatA

PKS_AT (583..889): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 63.5
Methoxymalonyl-CoA: 60.0
Malonyl-CoA: 45.1
Propionyl-CoA: 29.6
Ethylmalonyl-CoA: 26.7
fatty_acid: 18.6
3-Methylbutyryl-CoA: 14.2
CHC-CoA: 11.7
Isobutyryl-CoA: 11.1
Benzoyl-CoA: 10.4
inactive: 9.0
2-Methylbutyryl-CoA: 8.7
trans-1,2-CPDA: 4.3
Acetyl-CoA: 0.0

otaB

Search NORINE for peptide: strict or relaxed

AMP-binding (205..600): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: TVCWTGSGWK
Nearest Stachelhaus code(s):: Asn DVAFTGSIWK (41% 8Å match)
Stachelhaus code match:: 60% (weak)

AMP-binding (1269..1667): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: pro (Pro)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DAIWCMAVLK
Nearest Stachelhaus code(s):: Tyr DAIDVGAVGK (56% 8Å match); Val DAWMFAAVLK (47% 8Å match)
Stachelhaus code match:: 60% (weak)