LOCUS       BGC0002603             17042 bp    DNA     linear   PLN 04-DEC-2018
DEFINITION  Aspergillus versicolor 0312 biosynthetic gene cluster of chevalone E
            and its oxidized derivatives, complete sequence.
ACCESSION   BGC0002603
VERSION     BGC0002603
KEYWORDS    .
SOURCE      Aspergillus versicolor
  ORGANISM  Aspergillus versicolor
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Nidulantes.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 18:04:33
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..5488)
                     /gene="cle1"
     CDS             complement(join(1..4719,4784..5488))
                     /NRPS_PKS="Domain: SAT (132-280). E-value: 2.9e-11. Score:
                     35.2. Matches aSDomain: nrpspksdomains_cle1_SAT.1"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (387-796). E-value:
                     5.5e-139. Score: 455.6. Matches aSDomain:
                     nrpspksdomains_cle1_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (906-1195). E-value: 1.7e-55.
                     Score: 180.3. Matches aSDomain:
                     nrpspksdomains_cle1_PKS_AT.1"
                     /NRPS_PKS="Domain: PP-binding (1612-1672). E-value:
                     4.1e-09. Score: 28.8. Matches aSDomain:
                     nrpspksdomains_cle1_PP-binding.1"
                     /NRPS_PKS="Domain: PKS_PP (1725-1791). E-value: 6.2e-07.
                     Score: 21.6. Matches aSDomain:
                     nrpspksdomains_cle1_PKS_PP.1"
                     /codon_start=1
                     /gene="cle1"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 210.7; E-value:
                     6.3e-64)"
                     /gene_kind="biosynthetic"
                     /product="polyketide synthase Cle1"
                     /protein_id="BBG28471.1"
                     /sec_met_domain="itr_KS (E-value: 1.3e-143, bitscore:
                     467.6, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 2.2e-56, bitscore: 180.3,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.1e-10, bitscore:
                     28.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSSIPSVIVCGSQTIPPSRETLDNLASYLTKSPNPELKAVREVL
                     LALPELWAELKATEPQFQALSDEPIITFRDWFLRHDTGSEYEDNIYNLSHLKIHERLPN
                     ILLAPLTVIIHIAQYSQYLDGLGLDDSDDCHVHIRQSTSSRNTTDIGPKFQGLCIGSLS
                     AAALDASPTRTALAQNATAAVKLALCIGAYVDSQRLADSGSSSYSEMACFISRWGADCC
                     REMVEEMLSRYPEAYISVELDYNSITITAPSGDMPSLQEDLSREGVRVANVPVNGRYHH
                     SNNGRSLQSLLQLCCSDPCGPFWVPWGQDRLERYLRSILTEPAGWFSDMSETINSITPS
                     ETQMPMTTLELGLVSCIPPSLAALPRHHIIRGSLSPPTQPYNYPDTSIAIIGAACKYPG
                     ANSLDELWNIFAAGQVMYGEAPPGRFGKETVAGNFLSDADQFDYGLFGISPREAMYMDP
                     QQRIALQVAYQAVESSGYFGSPNPDGDVGCYIGVGNSDYEDNVHSNTPTAYSFTGTSRA
                     FVSGRISHYFKWTGPSITIDTACSSSAAAIHQACSGIILGDCSVALAGGVNIMSSFPAD
                     QNIAAAGMTNSTGPCRPFGADATGYSRGEGCGLIVLKRLADALSQGDNVLGVVVATAVN
                     QSDGSSSITVPVLRSQSDLYRRVLSRASMKASDVSYVEAHGTGTQRGDPIEYQGAREVF
                     GSSGRYQAKSHKVYIGSVKANIGHTEAASGVAGVLKVLLMLKHGQIPPQASFTSLNPAI
                     PPSESGQISIATQLEKWKRNFRAACVNNYGAAGNNTAIIICQHPPKTLPSSTNTAQTLT
                     RYPFLITAQSQVSVRRYCLALAQYIETNSKPLSLAAAFSLVAQQQNRNLRHRIAFCASS
                     LPELWRLLTFHAQAAEDTSVLLPPSPRKQVKPIVLVFGGQTGSTLQFSKAVYDSSYHLR
                     QNMDKCDALIQEMGLPSFFPDIFSQEPIEDIVILHSCLFSVQYAYAKAWLDAGLSVHRV
                     IGHSFGQLTAMCISGVLTLENALILVIGRANLIRDCWGEEKGSMLSVQIDRAGAEALAW
                     SESSLGDDSIEVACYNGPNSHVLVGSELAITNVERRASTASLATKRLKTTHGFHSKLVD
                     AIMEQYSNLAHIVSYNAPVIPIETCSETASWKIFTPQLVTEHSRRPVYFCDAVRRVERD
                     LGPCIWLEAGSSSGAVILAKQSLTSKSNYICGLQLGSPSTNPLDSVVDTTLELWNQGSS
                     VQCWAYNPRDLVHPSHFLGLPGYQFDTSPHWLPCATTDHNKSNDPSPVIDGLISLERLS
                     RPEPRVSIFELDQKDWTLAHILRGREVLGGILWPLALYMGLISRAAALLTSSIPSASRL
                     IRFAGLEIKTPLGSDLLNGLCLRLKQVEAWSWGFSLESDCARHATGTVIVDDERTSRPP
                     DHLSSLPDFATATTVFSAPRGVAYKLLEKVAEYDTAYRGLESISMNEDTAIARVHLPPA
                     AGNSRFVGNTITLDQFLLVAEIHALSMEDSKRSEVFACSGFGETTISANFMRATERDRG
                     QTWQVYTRQSAKRGREFLYDTFVYEAGEGEESGSLALALTGARFIRTSTSALQQVVELA
                     NTPSRSPVTEEIAPSPNFLQFQEGSANVWSLTVNLLHELTGCALEEISPQTILADMGMD
                     SLAIMEIEARIREVFNVDIRISPVDMGSTVEIICERITAQTSPSHGLVNVVGNSTSNTT
                     SSSSQCTPSSSFESDSDTQATELSLSAPTMEKVARVVATHVGSGEAVLSSSRLHSLGLD
                     SLAVLELQSDLHVNFGVRVHLMQLDCSTTIGDLHALVMRRGVRENIYNGAV"
     misc_feature    1..17042
                     /note="biosynthetic gene cluster of chevalone E and its
                     oxidized derivatives"
     protocluster    1..17042
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[0:5488]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..5488
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..17042
                     /SMILES="CC(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="neighbouring"
                     /product="T1PKS"
                     /product="terpene"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..17042
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002603"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..17042
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="T1PKS"
                     /product="terpene"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     aSDomain        complement(52..249)
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cle1_PKS_PP.1"
                     /evalue="6.20E-07"
                     /label="cle1_PKS_PP.1"
                     /locus_tag="cle1"
                     /protein_end="1791"
                     /protein_start="1725"
                     /score="21.6"
                     /tool="antismash"
                     /translation="TMEKVARVVATHVGSGEAVLSSSRLHSLGLDSLAVLELQSDLHVN
                     FGVRVHLMQLDCSTTIGDLHA"
     aSDomain        complement(409..588)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cle1_PP-binding.1"
                     /evalue="4.10E-09"
                     /label="cle1_PP-binding.1"
                     /locus_tag="cle1"
                     /protein_end="1672"
                     /protein_start="1612"
                     /score="28.8"
                     /tool="antismash"
                     /translation="NLLHELTGCALEEISPQTILADMGMDSLAIMEIEARIREVFNVDI
                     RISPVDMGSTVEIIC"
     aSModule        complement(409..4263)
                     /complete
                     /domains="nrpspksdomains_cle1_PKS_KS.1"
                     /domains="nrpspksdomains_cle1_PKS_AT.1"
                     /domains="nrpspksdomains_cle1_PP-binding.1"
                     /iterative
                     /locus_tags="cle1"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       complement(1243..1272)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cle1_0006"
                     /evalue="9.30E+01"
                     /label="PKSI-KS_m5"
                     /locus_tag="cle1"
                     /protein_end="1394"
                     /protein_start="1384"
                     /score="-1.7"
                     /tool="antismash"
                     /translation="RHATGTVIVD"
     aSDomain        complement(1840..2706)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cle1_PKS_AT.1"
                     /evalue="1.70E-55"
                     /label="cle1_PKS_AT.1"
                     /locus_tag="cle1"
                     /protein_end="1195"
                     /protein_start="906"
                     /score="180.3"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="VFGGQTGSTLQFSKAVYDSSYHLRQNMDKCDALIQEMGLPSFFPD
                     IFSQEPIEDIVILHSCLFSVQYAYAKAWLDAGLSVHRVIGHSFGQLTAMCISGVLTLEN
                     ALILVIGRANLIRDCWGEEKGSMLSVQIDRAGAEALAWSESSLGDDSIEVACYNGPNSH
                     VLVGSELAITNVERRASTASLATKRLKTTHGFHSKLVDAIMEQYSNLAHIVSYNAPVIP
                     IETCSETASWKIFTPQLVTEHSRRPVYFCDAVRRVERDLGPCIWLEAGSSSGAVILAKQ
                     SLTSKSNY"
     CDS_motif       complement(1879..1923)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cle1_0005"
                     /evalue="4.30E+01"
                     /label="PKSI-KS_m3"
                     /locus_tag="cle1"
                     /protein_end="1182"
                     /protein_start="1167"
                     /score="-1.9"
                     /tool="antismash"
                     /translation="GPCIWLEAGSSSGAV"
     CDS_motif       complement(2359..2460)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cle1_0004"
                     /evalue="2.40E-13"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="cle1"
                     /protein_end="1022"
                     /protein_start="988"
                     /score="42.1"
                     /tool="antismash"
                     /translation="VIGHSFGQLTAMCISGVLTLENALILVIGRANLI"
     aSDomain        complement(3037..4263)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cle1_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="5.50E-139"
                     /label="cle1_PKS_KS.1"
                     /locus_tag="cle1"
                     /protein_end="796"
                     /protein_start="387"
                     /score="455.6"
                     /tool="antismash"
                     /translation="IAIIGAACKYPGANSLDELWNIFAAGQVMYGEAPPGRFGKETVAG
                     NFLSDADQFDYGLFGISPREAMYMDPQQRIALQVAYQAVESSGYFGSPNPDGDVGCYIG
                     VGNSDYEDNVHSNTPTAYSFTGTSRAFVSGRISHYFKWTGPSITIDTACSSSAAAIHQA
                     CSGIILGDCSVALAGGVNIMSSFPADQNIAAAGMTNSTGPCRPFGADATGYSRGEGCGL
                     IVLKRLADALSQGDNVLGVVVATAVNQSDGSSSITVPVLRSQSDLYRRVLSRASMKASD
                     VSYVEAHGTGTQRGDPIEYQGAREVFGSSGRYQAKSHKVYIGSVKANIGHTEAASGVAG
                     VLKVLLMLKHGQIPPQASFTSLNPAIPPSESGQISIATQLEKWKRNFRAACVNNYGAAG
                     NNTAIIICQH"
     CDS_motif       complement(3253..3297)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cle1_0003"
                     /evalue="5.60E-04"
                     /label="PKSI-KS_m6"
                     /locus_tag="cle1"
                     /protein_end="724"
                     /protein_start="709"
                     /score="12.3"
                     /tool="antismash"
                     /translation="GSVKANIGHTEAASG"
     CDS_motif       complement(3367..3414)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cle1_0002"
                     /evalue="2.50E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="cle1"
                     /protein_end="686"
                     /protein_start="670"
                     /score="13.1"
                     /tool="antismash"
                     /translation="YVEAHGTGTQRGDPIE"
     CDS_motif       complement(3787..3834)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cle1_0001"
                     /evalue="9.70E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="cle1"
                     /protein_end="546"
                     /protein_start="530"
                     /score="17.7"
                     /tool="antismash"
                     /translation="GPSITIDTACSSSAAA"
     protocluster    4480..17042
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[14479:15802]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      14480..15802
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="2"
     cand_cluster    4480..17042
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="2"
                     /tool="antismash"
     aSDomain        complement(join(4585..4719,4784..5092))
                     /aSDomain="SAT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cle1_SAT.1"
                     /evalue="2.90E-11"
                     /label="cle1_SAT.1"
                     /locus_tag="cle1"
                     /protein_end="280"
                     /protein_start="132"
                     /score="35.2"
                     /tool="antismash"
                     /translation="DCHVHIRQSTSSRNTTDIGPKFQGLCIGSLSAAALDASPTRTALA
                     QNATAAVKLALCIGAYVDSQRLADSGSSSYSEMACFISRWGADCCREMVEEMLSRYPEA
                     YISVELDYNSITITAPSGDMPSLQEDLSREGVRVANVPVNGRYH"
     gene            order(6017..6482,6550..6618,6679..7335,7398..7840)
                     /gene="cle2"
     CDS             join(6017..6482,6550..6618,6679..7335,7398..7840)
                     /codon_start=1
                     /gene="cle2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 114.2; E-value: 1.2e-34)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450 monooxygenase Cle2"
                     /protein_id="BBG28472.1"
                     /sec_met_domain="p450 (E-value: 3.5e-35, bitscore: 110.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQTQLQLQLQGVSIFHQLGLLIGLSLILSITWTAYTILSPYLRV
                     KGKRIFNDRGRSELLWTGARKRFQAGARDLFKSAFAQNPDAFYIMTDTDVELILNSKYA
                     AEVRNDKRFDIGKYNEDMFHGTIAGFEMFEDDHVLERVFVETVRNKLTRAIGKFVEPMS
                     QEAADGLQKQWTDNTEWHALPLHQSILRTISQQSSRVFQGFPLCRNPDWLRITVNHTVT
                     FFEAAESLKVWPHPLRPLAAKFLPLCRKLRAEAEEARGIIAPVLKERRARRTQQVEQSI
                     EKNTKNEKKEDEDEDQNEDEETPGDMIEWAEQTANGAIYDPALLQMKVSLASIHTTSDL
                     VSQAIFNLCSRPELVDDLRKEVISVIGQQGWVKTAIYQLKLMDSVLKETQRLKPISIGT
                     MVRTTTSPVTFTDGLQVPPNTRTLVSCHNMWTDAVHANAAEFDGYRFLKLRQKPGQENW
                     TQLVSTSNNHLGFGHGMHACPGRFFAATTAKVLLAHVVLKYDLKLLDDQKPDIIEHGAA
                     QYANVWCGIGVRRRKEEIDLACPMATV"
     gene            complement(8161..9796)
                     /gene="cle3"
     CDS             complement(join(8161..8634,8683..9053,9106..9383,
                     9444..9796))
                     /codon_start=1
                     /gene="cle3"
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 264.4; E-value: 3.2e-80)"
                     /gene_kind="other"
                     /product="flavin-dependent monooxygenase Cle3"
                     /protein_id="BBG28473.1"
                     /transl_table=11
                     /translation="MYRVRSMESTATSSPSSSLMVHPTNFRVIIVGGSIAGLTLAHCLS
                     KIGVDYVILEKRQQIAPQEGASIGILPHGGRILDQLGLFNAIQRNVEPLTTAHISYPNG
                     FTHTNQSPTLIHERFGLPLAFLERRKLLQILYWSLPDTSRVQVGKTVVSVDHIWGDSGM
                     AVRTRDGSTFYGDIVVGADGVHSRVRHEMWRLAEIDLPGSITEREKDGMTVDYICVFGI
                     SASVPDLRPGEQVASLHDGRSFLVFPGKDGRVFWFLLKKLDRRYTYTSAPRLTPLDIDT
                     IAGSFISDHIWNGVSFGSLWERREVTGVTNLEENVFSTWHSGRIVCIGDSMHKMAPNTG
                     QGANCAIEDAAALANAIHGAIEHVDRPSMAEVQSFLRSFNESRLPRVREIYKSASVVVR
                     LHARENLALRLVGRYYLPYSGDVPANTASKLIADGVQLSFLAPSLHSGPGWEKYSMKNG
                     VAKSTVVWTSLGILGLVVFLFLLFRVRARFSSF"
     gene            order(10464..10646,10705..10812,10864..11032,11086..11676,
                     11735..12174)
                     /gene="cle4"
     CDS             join(10464..10646,10705..10812,10864..11032,11086..11676,
                     11735..12174)
                     /codon_start=1
                     /gene="cle4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 122.6; E-value: 3.6e-37)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450 monooxygenase Cle4"
                     /protein_id="BBG28474.1"
                     /sec_met_domain="p450 (E-value: 5.4e-38, bitscore: 119.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVFDIFTSSTFFTSPFPLTVGILSISLSGVLWYLRRAKAPTQAD
                     APPVYPFDPTTLDRKECKPPILTFGNSMILPNRYAHEIRNNDLLSFRDGLEKDFLTTVP
                     GLEALFTGTFHNDIVWDTASAFSRKIGLLIEPLSTETGIFLQENWSEDTEWHTIPLNES
                     MQFLIAQLTARIFVGNELCRNRDWIQLALGYTANRAAAIKELHQYGRLIPIVHWFLPSC
                     RALRACVRNARPLVEGILNTHRKKHQGEQKEESLDALSWIDGVAGETGVKYDPTLTQLR
                     LAYAAVHTTSDMMTKVLAAICEHDELVKPLREEIVAVVKEHGWTEAALAKMLLLDSVLK
                     ETQRLEPLASFTLSRIAREGVTLNDGTRVPKGTQARLTTDNMWNSGIYPEAARFDGYRF
                     VKLRDQDTATGASSGGLSFVSVSANHMGFGYGKHACPGRFFAGAETKIALCHILLKYDL
                     ELVDRELAGAKTDGMMIWRDKRAMLRVKRRSDDIGLEF"
     gene            complement(12299..13388)
                     /gene="cle5"
     CDS             complement(join(12299..12869,12934..13228,13289..13388))
                     /codon_start=1
                     /gene="cle5"
                     /product="prenyltransferase Cle5"
                     /protein_id="BBG28475.1"
                     /transl_table=11
                     /translation="MTYKQRNTNQLAIDLITLSRFNRYNPLLATFSGVWATILAGSHKI
                     THSPNSVTSEYVLSQALLCFICSFVFCGAGMVWNDWIDLHIDRQVARTKGRPLARGAVT
                     TSEALVWMAFQFISSWVLVSWMLEGENVQAAMLPVTLSTILYPFAKRPIFRRLHIYPQY
                     LLGFTLAYPSLIGTLAIKPEGNAQPLWASINQSLPMFVTVFTWTLYLNTAYSYQDVVDD
                     QKMNVNSAYVLAGSYIHHLLVVLAVLVLGAVGWQLYGQESQWLWGGWMGVWTWSFLGQL
                     VRFDKSRPESGGPLHKENFALGVWTVFVCVVELLIGGNGC"
     gene            complement(14480..15802)
                     /gene="cle6"
     CDS             complement(join(14480..14876,14938..15267,15342..15496,
                     15542..15802))
                     /codon_start=1
                     /gene="cle6"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 240; E-value:
                     4.8e-73)"
                     /gene_kind="biosynthetic"
                     /product="geranylgeranyl pyrophosphate synthase Cle6"
                     /protein_id="BBG28476.1"
                     /sec_met_domain="fung_ggpps (E-value: 2e-140, bitscore:
                     455.2, seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="fung_ggpps2 (E-value: 1e-97, bitscore:
                     314.9, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHSVRTSTTSTSSMVSSTMHPFDAFNAPQPYQQHHPPRWNIHNPH
                     FSQTNGHSIQKTPSMIKLHSSEGTVPTTNGADTLHQRNMEEKIISAPLHYITGLPGKDI
                     RGKLISAFNEWFRIPDEQLEIIKRVVGLLHVASLLIDDIEDSSKLRRGFPVAHSIFGIP
                     QTINSANYAYFQAQSEVLKLRNCNAAFTIFTEELLRLHRGQGMDLYWRDSLTCPTEEEY
                     LDMVANKTGGLFRLAIKLIQLESDVEDDCVPLVDLLGIIFQIRDDYQNLQNEQYAKNKG
                     FAEDITEGKFSYPIVHSIRSGAANCSSGSSELMNILRQKTDDEAVKRYTICILEKTGSF
                     EYTRRKLTELMAAARAMLAEFGSAEAAGLGGILDFLELKE"
     gene            order(16260..16786,16841..17042)
                     /gene="cle7"
     CDS             join(16260..16786,16841..17042)
                     /codon_start=1
                     /gene="cle7"
                     /product="terpene cyclase Cle7"
                     /protein_id="BBG28477.1"
                     /transl_table=11
                     /translation="MEEGWDFDSSPPSFKQVQPLLLTLFSLSGTGWLINYITTIRTAYR
                     DRTPGVSLVALTNNLAWELVFAILHPPPLPVAKVILRSWLFVDIFVIYTTAKFARSSSI
                     SSNAPLLHRYLHLFVLFGILGFFSGHWALSVLLSPIKAFYWSGMMCLVVMSGTALGILV
                     QRGHTRGMSYGMWFSRFVGSIFAVASLFLRSTYWPQVWGWSDNILMRWFAGAFVVLDGL
                     YGVCFWYTRRVEQRQRDKVA"
ORIGIN
        1 ctagacagcc ccgttatata tattctcacg cacgccacga cgcataacca acgcatgcaa
       61 atcaccgatt gtagtgctgc agtcaagctg catcaaatga actctcaccc cgaagttgac
      121 atgaagatcc gactgcaact ccaagacagc cagagagtca agaccaagac tgtgaagtcg
      181 cgagctggac agtacagcct ccccactgcc tacatgggtg gccactaccc tagctacctt
      241 ttccatggtg ggagcgctta gactcagttc cgtagcttga gtatcgctgt cggattcgaa
      301 agaggaagaa ggtgtacact gagaggaaga tgaagtcgtg ttcgaggtcg aattgccaac
      361 aacattaaca agcccatggc tcgggcttgt ctgtgctgta attctctcgc agatgatctc
      421 gacagtgctc cccatatcga cggggctgat gcggatatcc acattaaata cttccctgat
      481 cctggcttcg atctccataa tagctagaga gtccattccc atatctgcca ggatcgtttg
      541 aggtgagatt tcctctagag cacatcccgt gagctcgtgc agtaaattca cagtgagtga
      601 ccagacatta gcggatccct cttgaaattg caaaaagttc ggactgggag caatctcctc
      661 agtcacagga gatcttgatg gagtattggc tagttcaaca acctgttgaa gcgcgctcgt
      721 tgaagtcctg atgaacctcg caccggttag ggctaaagct agagacccag attcctcgcc
      781 ctcaccggcc tcatacacaa aggtatcgta taaaaattct cgaccccgct tagccgactg
      841 tctggtatag acttgccagg tctgaccgcg gtctctttct gttgctctca tgaaattcgc
      901 cgaaatggtt gtttcgccga agccagagca ggcaaagacc tcggaacgtt tagagtcttc
      961 catactcagg gcgtggattt cagcaactaa aagaaactgg tcgagggtaa tggtattacc
     1021 gacaaatctc gaatttcccg ctgctggtgg aaggtggaca cgggcaatgg ctgtatcttc
     1081 gttcatgcta atcgactcga ggccgcggta tgcagtgtcg tattctgcta ccttttcgag
     1141 aagcttatac gctacacctc tcggcgctga gaagacggtg gtagcggtag caaaatctgg
     1201 gagactggaa aggtggtcgg ggggtctact ggtacgctcg tcgtccacga taacagttcc
     1261 tgtggcatgc cgggcacaat cactctctag ggaaaacccc caactccagg cttcgacctg
     1321 cttcaagcgc aagcaaagac cattcaataa atcagagccg agaggtgttt tgatttccaa
     1381 cccggcgaac cgtataagac gggatgctga gggaatgcta gatgttagga gagcggccgc
     1441 tcgagaaatc aatcccatgt acagagcaag cggccagaga attccgccca gaacttcgcg
     1501 ccctctgagg atatgtgcaa gggtccagtc tttctgatca agttcgaaga tggagacacg
     1561 gggttctggg cgtgagagac gttccagcga tattagcccg tcgattactg gtgaaggatc
     1621 gttgcttttg ttatgatcag tagtggcaca ggggagccaa tgtggacttg tatcaaactg
     1681 gtaccctgga agacccagga aatgactagg atgaaccagg tctctgggat tatacgccca
     1741 gcattggaca gatgacccct ggttccatag ctccaatgtc gtatcgacaa ccgaatccaa
     1801 tggatttgta cttggcgacc ccagctgcag tccgcaaatg tagtttgact tgctggttag
     1861 cgattgcttc gctagtataa ctgccccgga gctagagccc gcctctagcc agatacatgg
     1921 cccaagatct cgctctactc tgcgtaccgc gtcgcagaag tagactggcc tgcgtgaatg
     1981 ctcggtcacc agctgtggag tgaatatctt ccatgaggca gtctcagagc aggtctcaat
     2041 agggataacg ggggcgttat aagagacaat atgggctagg ttggaatact gctccatgat
     2101 ggcgtcaaca agtttagagt gaaagccgtg ggtggttttg agtcttttgg tggccagtga
     2161 tgcggttgat gctcttctct ctacgttcgt gatggccagc tcgctgccca cgagaacatg
     2221 gctgtttggt ccgttgtaac aagcaacctc tatagagtcg tctcctaggc ttgattctga
     2281 ccacgccagg gcttctgcac cggctctgtc aatctggacg gagagcatag agcccttctc
     2341 ctctccccag cagtccctga ttagattcgc ccttccgata acaagtatta atgcattttc
     2401 gagagtaaga acgccagaaa tacacatcgc tgttagctgc ccaaaactat gaccgatgac
     2461 tctgtggact gaaagccctg cgtctagcca ggctttagcg taggcatact gcactgaaaa
     2521 caggcagctg tgaagaatta ctatgtcttc aatgggctct tgactgaata tatctgggaa
     2581 aaagctgggt aatcccatct cttggatcag cgcatcgcac ttgtccatgt tctgacggag
     2641 atggtaagac gagtcataca ctgctttgct gaattggagt gtcgagccag tctggccgcc
     2701 gaagaccagg acaatgggct ttacttgttt tctgggagat ggtggtagca gtaccgatgt
     2761 atcctcggca gcttgggcgt gaaatgttag gagtctccat agctctggca gtgagcttgc
     2821 gcagaaagct atacggtggc gtaagttgcg gttctgctgt tgcgcaacaa gggagaaagc
     2881 tgcggccaac gagagaggtt ttgaatttgt ctcaatatat tgagcaagag caagacaata
     2941 tcttctcaca ctaacctggg actgcgcggt tataagaaag gggtatcgag ttagggtttg
     3001 cgccgtattt gtagaggagg gcagcgtttt tggcggatgc tggcagataa taatggcagt
     3061 attattacca gctgccccat agttgttgac gcatgctgct cggaagtttc ttttccactt
     3121 ctccagctgt gtggcgattg aaatctgacc agattctgag ggtggaattg cgggattcag
     3181 actggtaaag cttgcttggg gtgggatctg gccatgcttg agcatcaaca agacttttaa
     3241 caccccggcc acccctgacg cagcctccgt atgcccgata ttggccttaa cggagccaat
     3301 atagacttta tgactttttg cctgatatct cccactgcta ccgaagacct ccctagcacc
     3361 ttgatattca attgggtctc cccgctgcgt cccagtgcca tgagcctcga cataagagac
     3421 atccgatgct ttcatagagg cccgagacaa aacgcgtctg tataaatcac tttgagaccg
     3481 caagacagga acagtaatag agctgctccc atccgactga ttcaccgccg ttgccacaac
     3541 cacaccaaga acattatcac cctgagaaag ggcatcggcc agacgcttca gcacgattaa
     3601 cccgcatccc tcgccgcgag agtagccagt agcatctgca ccaaatggcc gacatggccc
     3661 agtcgagttc gtcatccccg cagctgcaat gttctggtct gcagggaagc tcgacatgat
     3721 attcacccct ccagctagtg caacagagca gtcccccaaa atgataccgc tgcaggcttg
     3781 atggattgct gccgcggatg aggaacaggc agtgtcgatt gtgatagagg ggcctgtcca
     3841 tttgaagtag tggctgattc ggccactgac aaatgcccgt gatgtccctg taaatgaata
     3901 tgcggttggc gtgttggaat gtacattatc ttcatagtca gagtttccaa ctccaatata
     3961 gcacccaacg tcaccgtctg gattagggct gccgaaatac ccactcgact caacagcctg
     4021 gtaagcgacc tgcagagcaa tgcgttgctg gggatccatg tacatggcct cgcgtggaga
     4081 tattccaaaa aggccataat cgaattgatc agcgtcggag aggaagttgc cagctacagt
     4141 ctcttttccg aatcggccag gaggagcttc gccgtacatt acctgtcctg ccgcaaagat
     4201 attccacagt tcgtctagac tgttcgcgcc agggtatttg catgctgccc cgatgatggc
     4261 aattgaggta tctgggtagt tgtagggttg agttggcggg gacagtgatc cacggatgat
     4321 atgatgacga ggcagcgcag ccagtgatgg ggggatgcag ctcacaagtc ccagctccaa
     4381 agtagtcatt ggcatctgtg tttcagacgg tgtaattgaa ttgattgttt ccgacatatc
     4441 cgagaaccac cccgctggct ctgtaagtat tgaccgcagg tagcgctcta gtctatcctg
     4501 cccccatgga acccaaaatg gaccgcaagg atcagagcag cataattgta gtagactttg
     4561 cagagaccga ccattattac tgtggtgata ccgcccgttt actgggacat ttgccactcg
     4621 cacgccttct ctgctcaagt cttcttgtag agagggcatg tcgccgcttg gtgccgtgat
     4681 ggttatgctg ttgtagtcca gttcaactga tatgtaggcc taaggattac tttgcttagc
     4741 ataaccatat cgaagcttgc atctaagcac gcatagaaca tacctcagga taccgactca
     4801 acatctcctc caccatttct ctacaacagt ccgctcccca ccgggaaata aaacatgcca
     4861 tttcagaata ggagctggag ccagagtcgg ccagtctttg agaatcaaca taagccccaa
     4921 tgcacagtgc aagcttcaca gcagctgtag cattctgcgc gagtgctgta cgcgttggtg
     4981 aggcatcaag cgctgcggca cttagcgagc cgatgcagag gccttgaaac tttggcccta
     5041 tgtctgttgt atttcgagaa gaagtagact gccgtatatg gacatggcaa tcatcactat
     5101 catctaaacc gaggccgtca agatactggg aatactgcgc aatgtgtatt atgaccgtca
     5161 gcggggcgag gaggatattc ggcagcctct catgtatctt gagatgtgac aggttgtaga
     5221 tattatcctc atattcactg ccagtatcat ggcgcaaaaa ccaatcccta aaagtgataa
     5281 tcggctcatc tgatagcgcc tgaaactggg gctcggttgc tttcagttca gcccacagct
     5341 ccggaagagc tagtaacacc tcacgtacgg cttttaattc tggatttggg cttttcgtca
     5401 agtaggaggc aagattatcg agggtttccc gggagggagg aattgtttgg gagccgcaga
     5461 caatgacaga agggattgag gaggacatga tggactggcg gtgctagaaa agactgtcaa
     5521 gtgaaaaata gggaatcatt acagaataat gtatgtagtt tatgctctta aagcatcttt
     5581 actgctctta gtccataaca tctgtatcta ccccgataag catgtccagc ccacgggctc
     5641 aggatagaac atacactaat atagtgctta ctatcagcca tataaattta gcacagaatt
     5701 aaggaataag aataactgca tttgaaacgg aggatatagc ggatatactc cccgttatcc
     5761 gggtaatatc gccttgcagg atgttctgca ctgcgtgcat agcccttatt agcatgtccc
     5821 caccagcgtt gtaatatagc atgcatccgg ttcctgctgt acaccgtact tttatcttac
     5881 aagccatacg tacaaatcgt cattctccag cctacaagta agacggcccc gacttgggta
     5941 caacgatccc ttgatgccgt tcagatatac acaacaagta ccaaaggagt cgatttaatc
     6001 tactatacaa aggaagatgc tgcaaaccca actccagctt caacttcaag gcgtcagcat
     6061 ctttcaccaa ctcggcctgc tcatcggctt gagcctaata ctaagtataa catggacagc
     6121 ctacaccatt ctatctcctt acctgcgcgt caaaggcaag aggatattca atgacagagg
     6181 aaggtccgag ctgctctgga caggcgcaag aaagcgcttc caggccgggg cgcgagatct
     6241 cttcaagtcc gcgttcgcgc agaatccaga cgctttctat ataatgacag acacagacgt
     6301 ggaattgatc ctcaactcca agtacgcggc tgaagtgcgc aatgacaagc gcttcgatat
     6361 aggcaagtat aatgaagata tgttccacgg gacgatagcg ggctttgaga tgtttgagga
     6421 cgaccatgtc ctggagcggg tctttgttga gactgtgagg aataagctga cgagggcgat
     6481 tggtaagctg gatttctcac cttggacgtt tcttgctgtg atagagatgc tgatatcaaa
     6541 gtaaactagg caagttcgtc gagcccatgt ctcaagaagc cgcggacggc ctgcagaagc
     6601 agtggaccga caacacaggt atctgaattt ccaaaccatt cccagctcca gctccagttt
     6661 ttgatagatg tataatagaa tggcacgccc tccctctcca tcaaagcatc ctgcgcacga
     6721 tctcccagca atcatcccga gtcttccaag ggttcccact ctgccgcaac ccagactggc
     6781 tgcgcattac ggtgaaccat acggtgacat tcttcgaagc agccgagtcg ctgaaagtat
     6841 ggcctcaccc tctccggcct cttgcggcca agttcttgcc tctgtgtagg aagcttcgtg
     6901 ctgaggctga ggaggcgagg ggtatcattg ccccagtgct gaaagagaga cgagctagac
     6961 gtacacaaca agttgaacaa tccatagaga aaaatacaaa gaatgagaaa aaagaagacg
     7021 aggacgaaga ccagaacgaa gacgaggaaa caccaggcga catgatcgaa tgggccgaac
     7081 aaacagccaa cggcgcgata tacgaccctg cgctcctgca gatgaaagtc tcgcttgcct
     7141 ctatccacac cacatctgat ctcgtcagcc aggccatttt caatctatgc agtcggccgg
     7201 agttagtaga tgatcttcgc aaagaggtca tctcggtgat aggacagcaa ggctgggtca
     7261 agacggcgat atatcagctg aaattgatgg acagtgtgtt gaaagagacg cagcgtttga
     7321 agccgatttc cattggtatg ctcctaatca tttttctctt cattatttga atatgttaat
     7381 gatatatcct gcttcaggta caatggtccg caccacaacc tcccctgtaa cgttcaccga
     7441 cggcctgcag gtccccccaa acacccgaac cctagtatcc tgccacaaca tgtggaccga
     7501 tgccgtgcac gccaacgccg ctgaattcga cgggtacagg ttcctgaagc tgcggcaaaa
     7561 gccgggccag gaaaactgga cgcagcttgt atcgaccagt aacaatcatc ttggctttgg
     7621 acacgggatg catgcgtgcc ccgggagatt ctttgcagcg actacggcta aagtgctcct
     7681 tgcgcatgtc gttctaaagt atgacttgaa gctacttgat gatcagaaac cggatattat
     7741 tgaacatggg gcggcgcagt atgcgaatgt gtggtgtggc attggcgtga ggaggaggaa
     7801 ggaggagatt gatcttgctt gtccaatggc tactgtgtaa tcaattatta ttccaatagg
     7861 atttaatgta ctgcataggt actcatatta ctatgttttg gtcctcttgg agtaggttct
     7921 tccaagatcc ttaaggaata tcatccccgt ctttagtaac gactactatt attcacagcg
     7981 cacaatacgc ctcatttggg acgacggaag gccgggccgt gtctaaaata ataagctaaa
     8041 atatacaaag gccgggaact tggtatgcta cactaagtcg agatcgctag atacacttgt
     8101 atagaatcag accctgaaca cagactaaag caaaaatacc ctgcagcgta caatatcacc
     8161 tcagaacgag gagaatctag cccgtacccg gaatagcagg aacagaaata caacaaggcc
     8221 aagaatcccc aagctagtcc agaccactgt gctcttggcg acgccgtttt tcatgctata
     8281 cttctcccac ccaggccctg aatgcaacga tggggccaaa aacgacaatt ggactccgtc
     8341 agcaatcagc ttcgatgctg tgtttgctgg cacgtcaccg gaataaggta agtaataccg
     8401 accaacaagt ctcaaggcca ggttctcgcg cgcatgcaga cgcactacca ccgatgcgga
     8461 cttgtagatt tctcgcaccc tggggagccg ggattcatta aacgagcgga gaaaggattg
     8521 gacttcagcc atggaagggc ggtcgacgtg ttcgatggca ccgtggattg cgttggcaag
     8581 tgctgcagcg tcctcaatcg cgcagtttgc tccctgccct gtattgggtg ccatctgccg
     8641 atactgttag ctggctgtta atgattaaag agagtgatat accttgtgca tgctatcgcc
     8701 aatgcagaca atccggcccg agtgccatgt ggaaaagacg ttttcttcaa ggtttgtcac
     8761 gccagtgact tctcttcgct cccagagact accaaagctg actccattcc agatgtggtc
     8821 tgaaatgaag cttcctgcta ttgtgtcaat atcaagaggg gtcaatcgcg gggcagatgt
     8881 atatgtgtat cgtctatcaa gcttcttcaa aaggaaccaa aacactcgac catctttgcc
     8941 tgggaatacg aggaatgacc gtccatcatg caagctcgcc acttgctctc cagggcgaag
     9001 atcaggcact gaagctgata tgccaaagac acagatgtag tcaaccgtca tgcctatcca
     9061 tgttagccac ctttgcactc catgatagag gcatgacaga cagaccatct ttctctcgct
     9121 cagttataga acctggaagg tctatttcag caagccgcca catctcatgg cgtactcgac
     9181 tgtgcacgcc atctgctccg acgacaatat caccataaaa ggtggaccca tctcgagtcc
     9241 gtacagccat accactgtca ccccagatat ggtcaacaga aacgaccgtc ttcccaacct
     9301 gcacgcggga agtatcaggc agagaccagt acaagatctg aagcagcttt cgccgttcca
     9361 gaaatgctag cggtagccca aatctttctc gtagtattag ctgaccgcca gatatcgaac
     9421 acagcagacg gacagcgaca taccgctcat ggattagagt tggcgactga ttcgtatggg
     9481 tgaagccatt aggatacgaa atatgagccg tagtcaacgg ctcaacattc ctctgaatcg
     9541 cattgaacag tcccaattgg tctaagattc gtccgccgtg aggtaggatg ccgattgagg
     9601 cgccctcctg cggagcgatc tgctgtctct tttctagaat gacgtagtca acgcctatct
     9661 tggagagaca gtgcgcgagg gtcaggcctg caatggagcc gccaacaatt attactctga
     9721 agttggtagg atggaccata agtgaggagg agggcgagga ggtggctgtg gattccatgc
     9781 tgcgtaccct atacatcggg ttgatttgat tctgctagaa gatagttcaa aataactggt
     9841 gtttagaaaa aggaataata atgaatgacg agtagaatag gccgttaatt gtgtgatgaa
     9901 gccctggaga tttgatagaa atgcaataga gcaccgagtc cgtcgcccct tcctcacccc
     9961 tgcattaatc gtaatttctt ctatattcct tggatacaca gcccgccttc cctacgacat
    10021 gatgattatt atggcgcagt actaggcata ttaagtgata gctgtatatt tgtctacgcc
    10081 agtcgctaac cggcgcgtcg gatacaggga agtagatatt gtagtacggc catgtaatta
    10141 aaattaccca gattgcccag tctataggta agcactaagt tggagtttac acctggccag
    10201 actcagctgg atagattgca gggacagaac agggcacact aacaagggtc tgtttacccc
    10261 gcggagggca actaatgtaa taaagaccag gttggaaatt tggtactaat ggaggcttcg
    10321 ctatagcaag acctagggaa gtgcatgcag gaaaccttct tgactttgga acctggatat
    10381 atgtaccaag ttgctactgg agattatatt agggctgtgt ccagcctaac agatcatgcg
    10441 agctactcat caccaaatca acaatgacag tatttgacat tttcaccagc tctacctttt
    10501 ttaccagtcc attccccttg actgttggca tcctgtcaat ctcattgtct ggggtgctct
    10561 ggtatctgcg gcgagcgaag gcaccgactc aggctgatgc tcccccggtc tatccgtttg
    10621 atccaactac tttggaccga aaagaggtat ctcataattc tcactagtga tgtagcataa
    10681 actgacaatt ctttcttgaa atagtgcaag cccccaatcc tcacgttcgg aaactccatg
    10741 atcctaccaa atcgctatgc acatgagatc cgaaacaacg accttctcag ctttcgagat
    10801 ggactggaga aagtaggttg cgtaaattta ttctcaaaaa tccactaaca atatgcaact
    10861 caggactttc taaccacagt ccccggccta gaagccctct tcacagggac attccataac
    10921 gacattgtct gggacactgc ctcagcattc tcgcgcaaaa taggcttgct gattgagccg
    10981 ctctctacag agacaggcat tttcttgcag gagaattggt ccgaggatac aggtatcctt
    11041 agtcttcatg aatagtgggg aattgctact aagtgataga accagaatgg cacaccatcc
    11101 cgctgaatga gtccatgcaa tttctcatcg cccagctcac agcccgtatc ttcgtcggca
    11161 acgagctctg tcgcaaccgc gactggatcc agcttgccct gggctacact gcaaaccgag
    11221 cggccgcgat caaggaactg catcagtacg gccgccttat tccgattgta cactggtttc
    11281 tcccgtcttg cagagcattg cgggcttgtg ttaggaacgc tagaccgctt gttgagggta
    11341 ttttgaatac tcacaggaag aaacaccagg gtgaacagaa agaggaatca ctagatgccc
    11401 tatcctggat tgatggcgtt gccggtgaga ctggggttaa atacgacccc acactcacgc
    11461 agctccgtct agcatatgca gctgtacata caaccagcga catgatgacc aaggtgttgg
    11521 ctgcaatatg tgagcacgac gagctcgtca aacccctccg cgaagagatc gtggctgttg
    11581 tgaaagaaca tggatggact gaagcagcat tggcgaagat gcttctgctt gatagtgtct
    11641 tgaaagagac gcagagactg gagccgcttg cgagctgtaa gttttattta tggtccgata
    11701 tgtaaagagt tccatacact aatacctgtg gtagtcaccc tctcgcgtat agcccgcgaa
    11761 ggcgttaccc tgaacgacgg cactcgcgtc cccaaaggaa cgcaagcccg tctgaccacg
    11821 gacaacatgt ggaattcagg tatctatccc gaggccgcaa gatttgacgg ataccgcttc
    11881 gtgaagcttc gtgaccagga tacagctact ggtgcctcat ccggtggcct ctcgttcgtc
    11941 agtgtcagcg ccaaccatat gggctttggg tatgggaaac atgcatgccc tggacggttc
    12001 tttgcgggcg cagagacgaa gattgcgttg tgtcatattc tgctcaagta tgatcttgaa
    12061 ctcgtggata gggagcttgc aggggcgaag acggacggga tgatgatttg gagggataag
    12121 agggcgatgt tgagggttaa aaggaggagc gacgatatag ggctagagtt ctagatagct
    12181 tgctggaaat tctcaagttt gatcggacgg attcaatatc ttcatgtcac gcatctctcg
    12241 aagttcaaac ctagccctaa cctcatgaca acacagctgt caatctactt gataaatcct
    12301 aacagccatt tcccccaata agcaactcaa ctacacacac aaaaaccgtc caaactccca
    12361 gcgcaaaatt ctctttatgt aaaggccccc cactctccgg cctgctctta tcaaacctaa
    12421 ccaactgccc caagaacgac catgtccaaa cccccatcca accaccccaa agccactgcg
    12481 actcctggcc atataactgc caccccacag cgccaagaac aagcactgcg agaaccacaa
    12541 gcaagtgatg gatataagag ccagccagga cataggccga gtttacgttc atcttctggt
    12601 cgtcgacgac gtcttggtag ctgtatgcgg tgtttaggta gagtgtccag gtaaagacgg
    12661 tcacaaacat aggaagactc tggtttatag aagcccagag gggctgtgcg ttgccttccg
    12721 gctttattgc gagcgtgccg attagagagg ggtaggcgag cgtgaatccg agcaggtact
    12781 gcgggtagat atgcaagcgg cggaagatgg gccgtttggc aaagggatac aggattgtgc
    12841 tgagggtgac ggggagcatt gctgcttgtc tgaatagaat tctttgttaa tgacctgaaa
    12901 agaaaaaggt tgtcaaggct tgcgcggact tacacattct ctccctctag catccatgaa
    12961 actagcaccc agcttgatat aaattgaaat gccatccaga ccagcgcttc agatgttgtg
    13021 acggctcctc ttgcaagtgg gcggcctttt gtccgagcta cctgtctatc gatgtgcagg
    13081 tctatccagt cattccagac cattccggca ccgcagaaga cgaagctgca tatgaagcag
    13141 aggagggcct ggctgaggac atattcggat gtgactgagt tcggggagtg ggtgatcttg
    13201 tgggatccgg ctaggatggt ggcccagact gtacggatca aaaggttagt tgaattaaat
    13261 agaagaatag aaagaaacgg gtatctacct ccggaaaaag tggcgagtag tgggttgtac
    13321 cgattgaacc tcgataaagt gatgaggtca atagctagtt ggttcgtgtt cctctgcttg
    13381 tatgtcattg tcggcttgat gtaagtatag gaagatttca atagggatag gcatgggaca
    13441 ctaatcagct tggattacag gtatttaaga atatttggct gagatagctt actgcatagg
    13501 agtgccgccg taaaagcact gggcattccg tttgagggca tagtgctcca atacctttgc
    13561 tatgcgggat tctaggtcaa ttactattca tgtatagtaa ttaggatatc caccttgatt
    13621 tactacgtac ttgctgtgct ctaagcttgc atatctagac ttctacttgc atgggactgc
    13681 cacagtatag cacgacggaa aggccttcaa cgcagactat gcaagcacag tatctactag
    13741 ttctgcttca tgtaagctga agatgtgctt tatcgaacta cctcaatcaa aacccaagca
    13801 cgagatttag cctaaagaat cttcatcaat gaaagtctcc accgggatgc actccattct
    13861 cttattgaca cggccaaaga aactctgacc ccgcttcagt ttgggttata ctctgcgccc
    13921 tggacggctc atcagggtcc agattcctac ggatatgtat agtataatag atagggtaga
    13981 atagtagcat aaagtacgtg tttatactct ggtccctgat ctgcataatg cacggagtaa
    14041 acccacgaat ctctgttatg ctggggattc tacgcctaaa accctttatc tcgtcaagga
    14101 tatcgttcct cataaacagc gaatcagcta gtactgcata tttagttgga gggggaaaat
    14161 agtaataata agctcgggcc gcatctccga atctcttcaa cgcttccgcc tgatccttgc
    14221 attcttctgc agcggaccgg aagttaccct tctgtagctg actgcatggg tgcctagact
    14281 tgtatattgg cgttggtaat tgctgagcgc tcattggtct ctttatagat ggttggatat
    14341 gcagtggcac cctaatatat attctatatt agacaataat gcctagcttg gtatgtaaat
    14401 acgtccatct caagtaattg aaaaacaaac atagtaaatt gaaattccca aagagtgaga
    14461 tctaaatcaa atagcaagct cactccttca actccagaaa atccaatatc ccccccaatc
    14521 cagctgcttc agctgatcca aactcagcaa gcatcgccct cgccgcagcc atcaactccg
    14581 tcaacttccg cctcgtatac tcaaaactgc ccgtcttctc cagaatgcaa atagtatatc
    14641 tttttacagc ctcgtcatcc gtcttctgac gcaggatgtt cataagttca gagctgccgc
    14701 tgctgcaatt tgccgcgcca ctccgtatac tatgaacaat cggatacgag aacttgccct
    14761 cggtgatatc ctccgcaaat cccttgttct tcgcatactg ctcgttctgg agattctggt
    14821 agtcgtcgcg gatctggaat attattccta gcagatcaac cagcgggacg cagtcgctgt
    14881 tccacgttag caagctctcc tgccctctct tccggataac aaggataaaa agcgtactct
    14941 tcaacatcac tctccaactg tataagctta atggcaagcc tgaataaacc acccgtctta
    15001 tttgccacca tgtcaaggta ctcctcctcg gtaggacagg tgagggaatc tctccaatac
    15061 agatccattc cctgccctct atgcagccgg aggagctcct ccgtgaagat agtaaatgcg
    15121 gcgttgcagt tccgcagttt cagcacctcg ctctgcgctt ggaagtaggc gtagttggcg
    15181 gagttgattg tctgggggat tccaaagatg ctgtgtgcga cggggaagcc gcggcggagt
    15241 ttggaggagt cttcgatgtc gtcgattctg cagttaatgt tagattgctg caacggtctc
    15301 caaggtttga aaagacgggt atgaggaggg agggaggcta cagtaatgag gctacgtgta
    15361 gtagcccgac cacccgcttt atgatctcga gctgttcgtc ggggattcgg aaccactcgt
    15421 taaacgctga gatgagcttt ccgcggatgt ctttgcctgg taggcctgtg atgtagtgga
    15481 ggggagcgga gatgatctac cgggctttag ttgacgtttt cttgaattat agaagatata
    15541 ccttttcttc catgttgcgt tggtggagcg tatctgctcc attcgtggtt gggactgtgc
    15601 cctctgagga atgtaatttt atcatggaag gagtcttttg gatggagtgt ccgtttgtct
    15661 gcgagaagtg agggttgtgt atgttccatc gaggtggatg gtgctgttgg tatggctggg
    15721 gggcattaaa ggcgtcgaac ggatgcattg tgctggacac catagatgaa gttgaagttg
    15781 tagaagtacg gacagagtgc atttattggt attaagatgg acttcgttta tattctgcag
    15841 ataattctag gagcaacgag acagcaatga tattgataca gcacatcagg aataagacga
    15901 ctggaggtaa ttcacaatac cagtgacaat ataaaaacat tagctctata ttttaacaga
    15961 agataggtga gttcagcatt ctgtccgaga tgcatactac gaattagggc tgaccagaac
    16021 aatcccgcca gctgcgtgtc tgaaccggta atactctgcg cagacgccaa taaacaccca
    16081 cttaacagac acggaggata ttccgaatca ttatgcgagg ctgaggggct ctgcaatgca
    16141 gctgcagggg tctcgatcca tagcctcctt cacacttccc ctcaatccaa gatgagggaa
    16201 agcatcttcc cagattccaa acctcgaaac aaccaccaaa gccctcactc ctatccatca
    16261 tggaagaagg ctgggacttc gactcatccc ctccctcatt caaacaagtc cagcccctgc
    16321 tgctaaccct cttctccctc tccggcaccg gctggctcat aaactacatc acgacaatcc
    16381 gcaccgcata tcgcgaccgc accccaggcg tgtccctggt agccctaacc aacaatctag
    16441 catgggaact tgtctttgca atcctgcacc cgccgccgct gccagtcgcg aaagttatac
    16501 tacgttcgtg gctatttgtt gatatctttg ttatatacac cacggccaag ttcgcgagat
    16561 cttcgtcaat tagctccaat gcaccacttt tgcacagata tctgcacctg tttgtgcttt
    16621 ttgggattct ggggttcttc tctggacact gggcgctctc ggtactgctt agcccgatca
    16681 aggcgtttta ttggagcggg atgatgtgcc tggtggtgat gagtgggacg gcgctgggga
    16741 ttctggttca gaggggtcat acgcgtggca tgtcgtatgg gatgtggtgt gttcctatat
    16801 tctactatgg gcgatgcgat agctaacttg gatgatgcag gttctcccga ttcgttgggt
    16861 cgatatttgc agtggcgagt ctgtttctgc ggtcgacgta ctggccgcaa gtatgggggt
    16921 ggtcggataa tatcctgatg cggtggtttg caggggcgtt tgtagtgctg gatgggttgt
    16981 atggtgtttg cttttggtat actcggcggg ttgaacagag gcagagagac aaggtggcct
    17041 aa
//
