LOCUS       BGC0002608             23671 bp    DNA     linear   PLN 27-JAN-2018
DEFINITION  Aspergillus steynii culture CBS:112.812 ochratoxin A biosynthetic
            gene cluster, complete sequence.
ACCESSION   BGC0002608
VERSION     BGC0002608
KEYWORDS    .
SOURCE      Aspergillus steynii
  ORGANISM  Aspergillus steynii
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Circumdati.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 18:05:01
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     mRNA            complement(join(<1..269,348..887,961..1368,1413..1452,
                     1503..1599,1650..>1774))
                     /product="halogenase"
     CDS             complement(join(1..269,348..887,961..1368,1413..1452,
                     1503..1599,1650..1774))
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119:halogenase (Score: 331.6; E-value: 1.4e-100)"
                     /gene_kind="biosynthetic-additional"
                     /product="halogenase"
                     /protein_id="AUS29501.1"
                     /sec_met_domain="Trp_halogenase (E-value: 4.1e-16,
                     bitscore: 44.9, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIPTKATVLVIGGGPGGTYAASALAREGVDTVLLEADVFPRYHI
                     GESLVASIRPLLKFIDLDDTFVNYGFVRKNGAAFKLNNQKEAYTDFILEPGAGTYAWNV
                     VRSECDELMFKHATKSGAKTFDGVKVTSIEFIPDENNVESPGRPVSASWKAKDGRTGMI
                     DFQYLVDASGRAGITSTKYLKNRTFNNYLKNVASWGYWRGATPYGVGTPVEGQPYFEAL
                     QDGSGWVWFIPLHNGTTSIGVVMNQEMATKKKKMSSVTSSRAFYLESVEGARGISRLLE
                     PATLDGDIKQASDWSYNASSYGSSHLRIVGDAGAFIDPYFSSGVHLALSGGLSAATSIC
                     ASLRGDCAEEAAWKWHSQGVANRYSRFLLVVLGATKQIRARDRPVMNKEGENGFDDAFT
                     VIRPVIQGIADVPGRTTQREVLDAVAFSTQVVEPTTEGTDQSWVEKDHGALSRDEEEVG
                     KVMNNLARAYKSQEVYEGLAARLEKGALGLQVAN"
     source          1..23671
                     /culture_collection="CBS:112.812"
                     /db_xref="taxon:306088"
                     /mol_type="genomic DNA"
                     /organism="Aspergillus steynii"
     misc_feature    1..23671
                     /note="ochratoxin A biosynthetic gene cluster"
     subregion       1..23671
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002608"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..23671
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
ORIGIN
        1 ttagttagcc acttgaagcc ccagtgctcc tttctcaagt cttgctgcga gcccctcata
       61 cacttcctgt gacttgtacg ccctagccag gttgttcatc accttgccaa cctcctcttc
      121 atcgcgagat aaagcaccat ggtctttctc gacccatgac tgatctgtgc cttcggtggt
      181 aggctctaca acttgggtgc tgaaggcgac agcgtcaagg acctctctct gggtagttct
      241 acccgggaca tcggcgattc cttgaatgac tgtagacaaa gttaagttca atcagtcgtg
      301 accgtcttga gcaaaagcga agtctatata atgggatgga tgcataccag gtctgatcac
      361 ggtgaacgca tcgtcgaacc cattttcacc ctccttgttc atgacaggcc tatctctcgc
      421 ccggatctgc ttcgtcgcgc caagcaccac taacaaaaag cgactgtatc gattagccac
      481 gccctgagaa tgccacttcc atgcagcttc ctctgcacaa tcgccccgta gagacgcgca
      541 aatagatgtt gcggcggaca gtccgccaga aagagccagg tggacgcccg aggagaaata
      601 cgggtcgatg aatgcgccag catcgccgac tatacgcagg tgggagctgc cgtatgaaga
      661 ggcattgtag gaccagtccg aggcctgctt gatatcgccg tcaagggttg caggttccag
      721 aaggcgagag attccgcgcg ctccttcgac tgactctaag tagaaagctc gactggaggt
      781 cacggatgac atctttttct tctttgttgc catctcctgg ttcatgacca cgccgattga
      841 agtcgttcca ttgtgcagag ggataaacca gacccagccg ctgccatcta tgtggaatca
      901 gtcgttagta tggcccctaa agtctagacc agcctgcggt ggtcaaggga ataaaccaac
      961 cctgaagcgc ctcaaagtac ggctggccct ctaccggtgt tcccacgcca taaggtgtcg
     1021 caccgcgcca gtagccccag ctagcaacgt tcttgaggta attgttgaag gtccggtttt
     1081 tcaaatactt ggtgctggtg ataccagctc gaccacttgc atcaaccagg tattggaaat
     1141 caatcatgcc tgtccggcca tctttggctt tccaactagc agacactggt ctaccgggag
     1201 actcgacgtt attttcatcg ggaatgaact cgatcgaggt gactttgacg ccgtcaaagg
     1261 tcttcgctcc ggactttgtg gcgtgtttga acatcagctc atcgcactcc gatctgacaa
     1321 cgttccacgc gtaggttcct gcgccaggct cgagaataaa gtcggtgtct aggatggtca
     1381 gtcgatgttt gacatgtaga gggtccactt acaagcttcc ttttggttgt tcaacttgaa
     1441 tgcagctccg ttctgcaatc gtttagtata tactggtggt gggggtccag atagacaaat
     1501 acctttctca cgaacccata gttcacgaac gtgtcatcca aatcgatgaa ctttagaagt
     1561 ggtcgaattg aggcgacgag gctttcaccg atatgatatc taaaaatgta agtgataaca
     1621 gtctagggat ttagacaaga ccctctaacc ttggaaacac gtccgcctcc aacagcaccg
     1681 tgtcgacacc ttcccgtgcc agtgctgacg ccgcataagt gcctcccggg ccacctccga
     1741 ttacgagtac tgttgctttg gttggaatgg tcattttcgt gaaccacaga ttgatcaggt
     1801 cgtgctagcc tggagatgtg tcattggggc cggacttctt ggttcagata tacttgctat
     1861 ccggggatat gctctcgctc agcagcaagt tgcttgtcgg agatatagag gctattgccc
     1921 ttcattacag gtattatctc aagaatgacg tgtaaaaggc tagattgagt catgtcagct
     1981 tagagctggg aggaaatcca gatgagcgag ctctttcagt tacacaaaag ttcatcggat
     2041 aatgaggtca cccgagactg tttttgtgca cttccacttc acagggactg cgatatatta
     2101 tgtcacataa aattaagcca tggttttgtt ccgagttatg tagcatgagc cagccccctc
     2161 agttgagact gttttgtcaa tataatagac ttaacaccca aggtcctttc tttttctcat
     2221 ttattcattc atctcaagct tcaacatcgc agaccattgc tacgacagga atgacctgtg
     2281 acctttacat tctacctacg cgtggcatac aaatgcaaat tatcacgtca caaacagcgg
     2341 gtaaatcttc atattttctt tttctttgaa gaaggcaacc gctcatccta gccgacgaga
     2401 gcaccatatg ctgcccatca gcggcaatcg ggaccccgcc tttccccgct caacaggata
     2461 ttcaacatac gtggagcagc agaggtcgtt cagattaatg gaactaaatg acgtgtaagt
     2521 gactctattt aaattgaaat taatctgtat actgcatgcc gagtccacag aagaaagcat
     2581 gctagataat cgatttatct tcactaagca tccggttccg ttccattact gcctggtagg
     2641 catcttgacg aaactagtta ctcccgtccc aaagataaac agtcgtatct cataaagcgc
     2701 cctacagaat tgaactgtgg gttccaaaat agaggggttt tggaatttcc cctcatgctc
     2761 gccactcaga aaatgacgct agtttcagct gaagacaggg aacaaaagta ctgtacatct
     2821 ccatgttcca tctcattttc tgtgcctcgg aattattatt ttctccatgg acttttgttc
     2881 gtcacatacg gcctgtttct agcttaatat aattctattt ttctcgcaga ctgattaggt
     2941 atctctattt ttgtccgagt ccagagtatt gataggtcgg aattcgaatt actcgttagc
     3001 ctggcagttg tttactgcta acgtaaaaat tgtatgaggt tgtcaaacat tgacattctc
     3061 gtgctcgaag attccactgg agagtacgca gtagaactgc tatgaacgaa taattccgac
     3121 agggttgggt ggcgttgctt gttctatttc agggtcacag cattccagga tatggccacg
     3181 cacacgcatc tggatctcgg ggaaatgacc aattagttcc ggtccctgga atgctccatt
     3241 gtctaataca gcaaccaaga ttagaatttc ctagaaagct cgaaaaatac gatcgcgaga
     3301 tctttcttta agaaattgta actaattaag gtgttatacc gatgaaaagt caggtcacat
     3361 ggttcgccaa gccctattta cattttgacg ggggattgtt tacatcggct cttcaggaac
     3421 tcttccccaa cgagtaatca tatccttatg gccgggagga gcacttaggt cgcagagaat
     3481 tgtctaattg cgtttgttga tcgtcctgtc aagttacttt aacacgcagc gcagcgctgc
     3541 actgcacagc aaggagtgcg acgcaatgca acccacgaga catctacctg cagcattgaa
     3601 tacgtgtaca acacgataat cagtcgggga gcttaacctc atgtgaagaa aatatcgagc
     3661 gcccagataa gaaaattggc tggagtcgcg atactccatt cagcaacgcc atcggtcggt
     3721 ggcgattttg aaaagagggg aatgccgatt taaccgcctt acggagcagg gtacctatct
     3781 ggtttgatct tagcaggtgc tcaatcctgg aaagctcgat ggtcgagacc ctgagagcta
     3841 ggattcgaca ggggtgtgct ccactcatct actgcgtaat ggcggacgga ctatcatgta
     3901 gcgtcgtgcc aataatgcgc ctaattgcgc gccacccaca cgatccacaa ggagcctatc
     3961 cccggcccgc tgcatggatc gcaaaacagc ccttggaatt tggaagcagg tgccatcctg
     4021 cgcttggcat aatggctttg gctctagtct ctgcccggcg cgcggctggc caatgggcga
     4081 cgaaatacac gagcagattt gtgaaaaatt aattgctcga caggttgaac tatgcagttt
     4141 ggggccatca ccgatgtcga tcaccttggc ctgtacatat gaccatatgg cgcgcaggcc
     4201 aggatttccc atcgttgaaa atcggtccgg ctacgctttg cggcggaaag ggtttgtttg
     4261 attgggacct acttcggcga tcgccgagct tattatagga ctaaagaaaa tgaagaagtt
     4321 gcaaagaaaa acatccgttg aaatttggag aatcattcgc gaagtgatta ttcctgtcac
     4381 tgagctactc aaactttgga cctcggccaa ttgttaacta gcagttctgt gaacctttgt
     4441 agttccagtt tccctgttca tgatagtgat aaaaaaaaga accccacaca atgtagtcaa
     4501 atcaatgtga attgtgagat ctgttatcga aggatgtcct gtgccaaaag acccaaagtc
     4561 tggagacgag cgccctgcga catcacgttg atgcaattcg acacgcgaat atgatgaagg
     4621 agctcttgct tgatcgcgta aagttccttc tgaatttgcc gaatctcgtc ctcaagggcc
     4681 cgtcttcgtc gctcttcgtc gcgtctctcc gcctctagca gagcgattaa atcgacctgc
     4741 ttctgccgcg actttccagc agccaatcgg ttgcgctcct tgtatttttc gtggtatttc
     4801 tgtctcagtt gtttcacttc gacgctcttt tcgaatgtgg gttgaggttc ggaagaaggc
     4861 gaatgcgctt cagccgaact tggttgtgcg gaagtgtcca tctgtccttg attcgttgtg
     4921 gagggtgtcg tgttaggtgg taagctgaat agatcctgtg ggtcggcgaa aagtgcagga
     4981 gccggcgtgg cattatcggc gccaccagct tgtagcccga gaattcgatc aagctcgttc
     5041 aagtctggca cggtgttctg gtatgaaaaa tgattgttgc tgttttctat cgttgtcgcg
     5101 gagagaccgt ttctatagac gattagagtc ggctctcaat gagagatagt ataggctctt
     5161 acgattcgaa agctcccctg ggggtgttgg agtcaacctg agctaccgaa acatttccat
     5221 tgccgtccaa ttgcgatagc atgtccgtcc agtcgactgg gagatctgtg gacaagcgaa
     5281 tgtcatccat tgtgaaacaa ggctttgggg gagaaaaagc aattgagagt cgatagagtt
     5341 tgtggaatgc aggttgctga gctcccagac gcgattgtat atcaacattt tctctcttca
     5401 gctcccccac ttaccgttgt gttctggagc tcaccccatg ccgggaaatc tgtataacag
     5461 gacgaacatt gcgttagaac atgcatcgga gatgcagcaa aggttaagtg gcgtcaggat
     5521 tcccggagat gagggggcga tatactcagc atcttgcccg gcttgcacta atgcattagc
     5581 aaactaggga agcagatcgg tttgaagatg agaatagagc gatctgcgac aagctaaaag
     5641 tacccgcacc tggactcttg ggtcaatttc atgctatcgg gtggtgtgct cactaggccg
     5701 atcggtagtg atggttgaaa caaacacaaa tggctggccc aaatgactac aatccacgag
     5761 tcagattccg aggaagcgat gaagaatgaa tggattgtaa ttttggccaa atcgcctatc
     5821 agcatcagtg gccggtatct caatttgagg ccccgacaaa gaacccgtgg gatctgggat
     5881 tctgtataga caaagtgaat aagcaacaaa cagtcggcag ccaaacttat tggatttaat
     5941 ttatcgcgat tctttcgggc aattatcgca gctgattatc cagtagaata ctcaaaagcg
     6001 gtactagggt aagctggttt cccaaagacg ccgattgcgt tatctgaaag caaaatcttc
     6061 caggaaaaca aggcgaacaa gacttcatta attggctgcg taaacaaaag tccatattcg
     6121 gcccatatgg aggagacaca tgcatgagct gaacacctca gtcacaatct attgagtcag
     6181 ccgtaagcta tcgcaaatcg tcaccagaaa cttttacacg tcatataaac acccatgctt
     6241 tttctcgacg ctaaagcact ccatgggccc ctgtaaataa aagcgccggc ctgaaaactg
     6301 cgtcgccacc ccatcccgca tttcccccct tcaatcaaca gcaagaagca tttaaccatg
     6361 gacttagaca tatttgcctc taaattccac cttcttcttt gggcattgtt ggccacgccc
     6421 gttatttacg tgcttactac tgtgacctac gagctgttct tttcgccgct gtcgcatatt
     6481 cccggtccta aactggctgc ttgcacgcgt ctctatgaat tttattacga cattgtcctg
     6541 catggcaggt atacgttcaa gattgctgag ctgcataaaa aatacggtac atgatcccga
     6601 ttccccgtcg atccaataaa cctgtttact aaatgcctca ggacccataa tccgcatcag
     6661 ccctggggaa gtccacatca atgaccccga gtattacgaa acactatact caatcaatgg
     6721 tccgcgcaac aaggactcat ggttcatcga atcattcgac gtggcccagt ctgccttcgc
     6781 cacgctcgac catcgcttac acagacctcg tcgcgccttg atcgctccgt acttttccaa
     6841 agcgcgagtg cagcgcgtgc agtctctgat ccagaacaag ctgcagaaac tgacaaaccg
     6901 attgaacgag gttgcacgct ccggaaagcc gctcaaggta gacgtcgcgt tcaactgctt
     6961 cacggccgac gtgatcactt cgtacaccag ctttcgcggg ttaaactacc tcgatgaccc
     7021 cgatatggta cccatttgga gcgagacagt ccgcaatctc gttgaagttg gaatgatcgc
     7081 gcgacatcta cctgggtttt tcccgcttct ggcaagtatg ggaatgaagt ggatccagcg
     7141 aatctatccc aaattgcttc ctgtcatcgc cttccggatg aaatgtgccc aggaggtgaa
     7201 tttcatgtgg gagaacgaag aaaaagcaag cgaagatttt gcaaagaaca gtctctctca
     7261 agagcctgcg cttttccagg acatggtcgc caaagccccc gatacgcctg atatcaccga
     7321 ggctagggtc cttcatgagt atattactat cgtggcagca ggaactgaga ctacagcgca
     7381 tacgatgacg atctgtacgt ttcatgtgct taatgacgaa caggtcctgc gcaaattacg
     7441 tgcagagttg gaagaagcct tccccgacaa gaaagaaatg gatttacaga cgcttgagca
     7501 acttccttac ctagttagtt ccttcccacg tttgagtctc aaatcatgaa gctgacacca
     7561 ccagactggg attatttacg aaggactccg gtaggcgcac cctttttgca agagtcacaa
     7621 cttgagctaa tggcagcaaa acagactatc gtacggcctt tcccaccgtc tccaaagaat
     7681 atgtcccacc gatccactca agttcaggga tgtagtcatc ccacccaatg taggtacagt
     7741 tccaggccag cttagatcgg gagctaacag acctagacat cgatcggaat gtcctctgcc
     7801 cttatccatc acgacgagtc catctttccg aaatcccacg agttcatccc ggacagatgg
     7861 acagaccttg aggaccggaa gagattgaac agatacctgg tttcctttag taagggtgct
     7921 cgccaatgca tcggaatgaa gtgagtttct agtgtattcg ctcgtttcct gttcgctcct
     7981 cttacgccga tatgctaata tgactcgtca tagcttggca tttgcggagc tttacatggc
     8041 tgttgccacg gtcttccgca cgtttgatat gaagctgcac gagactacag tggatgatgt
     8101 tcggcttcat agcgacatga tgctaccaca tgccaagccc ggtagtaagg gcgtgagagt
     8161 agtgattgac cctatttagt cagatatccc tggattggga acagtatata ttacctaaac
     8221 cttgaatata gtgggggtta gaacactttg gtggataggt acgatgtctc ggcattatat
     8281 agtgtagagg ctacggactg agtgaatgaa taggccatct gctacaacaa ttaaattcca
     8341 tagttgaact aatggtaaac gtgaatcgag aaataatagc ttttctaaag gtaaaaaaaa
     8401 tggaaatgtc attgaggggt atttctgtat ttgacttttg ttgggttttt tctgttcgta
     8461 tcttgtgccg gtctcccttt ctacgacgcc actatcacaa catggcgata gtgaaatagc
     8521 gtcttttctg cattttgggg gcattttaat gactgaattg tatcccaaaa agtagcacaa
     8581 atccgtttat gcgcgtagaa gccgggaatc cttccactga cactctaact gaatactgaa
     8641 tgctgaatga aaattttttt tgaaatcact atcggcctct aaaatgacgg atcaagattt
     8701 ccgcataatt accactggat aaacgaactc ccgacttttt cttctggtcg atctagtaca
     8761 tgcagccaag atacgtggcg gtaccacgct atgacgtgta actactttgt tcctagcatg
     8821 gatgaggtgt agaaccatag aaaaaaaggc gctaatatat gtaattctta ctggttagta
     8881 aattaggcag gcccaactcg gataatttcg tattatatca ctttgatgta tctctgccct
     8941 tcggtgaaca tattccacga ccaccccccg cccgcgccaa aaggaaaacg acttacgctc
     9001 agaatcacgt tcaatggagt caggacacaa ttatcggttt ccctgtctaa cggatggtcg
     9061 tattgtggag gatgaaacgt ggaaattcgc cccacttgat gcggtcaagt actcagatct
     9121 caatatccaa gaagggactt cggcaaaatg gctcaatatc gcctgggctg ttctattatt
     9181 tgtctacgac gaggtggaaa ttataaaatt cgaatccatc tacaatggcg aaaggaaagt
     9241 tttgagtagc atggttactc gcgatcaacc gtggcaggac atcgatttcc attatgaaga
     9301 ctatgagtct gctcaaacca ataccggcgt ttgcatattc acagaacagg ttgccgatat
     9361 tccgccggtg agtaggaaag cgtgattgaa atccaactca gaactgatgc tcctaggaac
     9421 tgcaacttgc attggcggta caatgctcgg acggcttgac aatatctctg gcatatcgcc
     9481 cgcagctggt ttccgataga caagcactga acatcgctag cacgttcaac aagatcatgg
     9541 acgcattaaa agggccaaat attcctatat gcgcgattga catctgcgac gagcacaatc
     9601 tcgaccagat cgctaaattc aacactggtc cacgtcaagt caaggaggac tacctacaca
     9661 gtatcattga gagacaggca ctcgaagccc cggatcaagt tgccgtcgat gcatgggatg
     9721 ctcggttaac atacaaagaa cttgacttct ttgcgtccgt attagcaagt cgtctaagat
     9781 cactcaatgc agcaaatacc tatgtaccgc tgtgcgcaga gaaatcagcc tgggccgttg
     9841 tcgccatcct ggggattctg aaagccgggg ctgcctgttc gcctctcgag gcatctcatc
     9901 cccgcgatag gttagaaacc atgatccggt cttgtggtgc cacaactgtt gtggcaacga
     9961 aatcacacgc gtcactgttt cagctagacg gcgttgatgt cgttgtcgtt tcttctgaat
    10021 ctctatcgtc tgaaaaggaa tgtttgaatc tatccgatac cacggtcgct ccacgatctc
    10081 cggccttcct catgtggacc tctggaagca ctggtaaccc caaaagcgtg gttctggaac
    10141 atgcagccct atacatgagc atcaccacct acgcagaagc gagcaacctt tcagcccgga
    10201 caagaacatt ccaatttacg tctttcacgt tcaccgtcag tatatgcgac atctttggca
    10261 ccatgagcaa aggagggacg ttgtgtatgc cgtccgacga gcaacgtttg aacgatctat
    10321 ccggagcaat gaaagcctcg gctgcctcct tttgctggct tacctcgacc tccctgaccg
    10381 gactcgaccc tgaaaagctc cccgacctcc gctgtgtcac tgttggtggt gaatctcttt
    10441 cgcgggaaac ggtggtacgc tgggctggga aatgccaggt caatgtgtcg tacggcacaa
    10501 cggagacatg cggatggtgt ttgctgaacc caaatctgac accagagcgt gaatcccgag
    10561 ttctcgggaa gcctattatc cctgcagctt ggatatgcca tcctgacgat atcgagaagt
    10621 tggttcctgt cggtgcggtc ggcgagctgc tcattgaggg ccccttcttg gcgagggaat
    10681 atctcgatga tccggaacgc acggcagcgc aattcattca gccacccagc tgggcgaagc
    10741 tatttcgaac tgatccagca acgaggcttt atcggacgaa cgatctggtt cggtataact
    10801 ccgatggatc tatcatgttt gtaggccgga agcaggcaca tgcgaagata cgtggaaatc
    10861 ggatcaatct gatcgatatc gaacatcatg tgcgacgggc attgggaacc cccgaagcaa
    10921 tcgtcgacgt ggtgcacacc aaagacggta ttgatatgtt gacggcgttt ctgctcgcct
    10981 cttcgggcat gggcaacagt cagggctttg gaagccccgt gactcacgct gatgatgatt
    11041 tccgccaacg tgtcgccaat gctttggaag tgctagaggc aacgctgccc agttacatga
    11101 tcccaactgc cttcgtgccg ctgtctctaa ttccacttac gcgtaccaac aagacagaca
    11161 ggcgactgtt acgtgaagaa gccggggcgc ggaccagagc tgagctggta cagcttgcag
    11221 ctcccaaaag cgagaatgct aaagcgctgc tctcgggcga tgaatacatc atgcagaaac
    11281 tatggtccaa ggtgacaggc cttgctatcg acaacatagg ccctgacgac agcttctttc
    11341 acctaggtgg tgattcagtc atggcaattc gactggtttc gctggccagg aagcacgggc
    11401 ttatattcac cgtcatggat atgttccgtc actcaaagct gagagacctg gcaactttca
    11461 ttaccgggcg cggggaacag aattgggctg agcccagttc tgtgagcttc catgtcgaag
    11521 acctggttcc agacgcggcc agagagtgcg gggtggagtt taatgctatc gaagacttgt
    11581 atccgtgcac agcattgcaa gaggggttga tggcactatc ggcacagagg acaggtgcct
    11641 atatcctgca aatggcctgt gatataccat tgacagcaga agtgccccaa ttccttgcag
    11701 catgggagac cgtcttcgat gcgcttccaa tcctgcgcac acggattatt cagctaggtc
    11761 gaggaggatt ctatcaagct gtggtgaagg agaaaatgga ctggcgctct gtgaccagtg
    11821 agtcagaatg gcgcgactgg aatcagatgc accctatgca actaggctgt ccattggcac
    11881 gactcgcact tcttcatgtg gattcccgac cagtccgcat actaatcgct gttcatcatt
    11941 ccatttttga tcgctggtct acttcccttg tgcttgacat ggttgatcaa gtataccaaa
    12001 aacgggagat ccagcaacaa cagttcaaac attttgttga atatgtacac tctcgtccgg
    12061 tcgaatcaag tgatgctttt tgggatgatc accttcgaga tgctcagcac acggcctttc
    12121 ccaagattaa agacgcctcc cttttaccaa agccaaccat gtcaagaaac aaggccatta
    12181 cgctcgagtc ctcgcgaagc aatttcacag caacgacgaa actgcgcctc tgctgggctt
    12241 tagttctctc ccaacacaca gacagtaccg acgttgtgtt tggtgccgtc tcgacgggtc
    12301 gaagcgcccc tgtcgaaggc gtagagaact tagtcggtcc cactctagcg acagtgccat
    12361 tccgagtgag aatcaactcg gacatatcgg ttgcaaatgc ccttgagagc gtgcagagcg
    12421 acagcgcgtc aattattccc catgagcaac ggggtctaca acatatctcg agaatctctg
    12481 ccgacacgaa gagtgcttgc aaattcgaaa acattctgat cgttcatgcc ccgagttcag
    12541 gtggcggaat gagccttctc ggggacatgg cggatgacca gctgcctgaa ctgttcagct
    12601 acggccttac attgtcatgt gaagttatgg gaccggatcg gattcatgtc gatgcgttct
    12661 ttgatccgaa gataattggc gagaaacacg tggagacttt actttgccag cttgatcatg
    12721 ccatgcgaca aataaatgat gttccaagtt ctcaacttgg agacgttagg cttctcagtg
    12781 ccagcgacga ggaattgctc aaatcatgga actcccgtgt gttcacccaa agcagttcga
    12841 ctgttcatca aatcatccag gatcaatgtg caggatcacc cgatgcagag gcagtgtgct
    12901 cgtgggacgg gtcattgagt tatggcaaac ttgatgctct ttccactgga ctagccctcc
    12961 atctccgcca gcgtggagta ggaccggagg tctttgttcc cttacttttt gacaagtcga
    13021 aatggacggt ggttgctatc ctcggtgtcc tgaaagccgg tggtgctttt cttctactcg
    13081 atccgtcctt tcccaaagac agactacaaa cgatttgcaa ccaggtcaat gcgcgagtta
    13141 tactagcttc acagaagcat tcaaagccag cagggagtct tgtcggggac tgtttcgtgg
    13201 tggacgactc cctggagtac aacccagcac cttcagtcgc attgccgacc accgatccga
    13261 gcaacgctct ctacgccgtg ttcacgtcag ggtcaacagg gacaccaaaa ggtgttataa
    13321 ttgaacacgg ccagtatgcc tctggagcca aagctcatat ggcagctgca tcgatatcct
    13381 cggcatcccg ggtcctgcaa ttctcgtcct acgcgtttga cgccagtgtc atcgagcatc
    13441 taaccaccct gatggctggc gggtgtgtct gcatcgtttc agacaccgag cgcagcaact
    13501 ctttctccga ggcagtcgcg tctaggaatg ctaactggac atggttgacg ccaagcgttg
    13561 ttcgaaccat ggatcccaaa gactttgcgt cgctgaaaca cctttgtttg atgggcgagg
    13621 ctctcgggcc agcagaagtc cagaaatgga cccagcatgt tcacctcatg caagcatacg
    13681 gaccagcgga gtgctccgtc ctcgctacgc tacaaccttc tttcgaccta gactcggatc
    13741 ctcggaacat cggatttcca agtggttgtg ctgcatgggt tgtcgacaaa gatgacgcca
    13801 cccgtctggc gcctgtgggt gcggtcggag agcttctgat tgaaggtccc attgttggga
    13861 gaggctatca tcgcgacccg gagcagaccg ggaaagcctt cattaacccg cctgattgga
    13921 tcgatagatt tcggcaatct ggctctcgac gaattcatat gtacaggaca ggcgacttgg
    13981 tccagtacgc tccgcagctt gacgggacac tgctctatat ttcccgcaag gacacgcagg
    14041 taaagattcg tggtcagcgt ctggagcttc atgaagtgga gtatcatgtt ggtgaagtta
    14101 cggagccgtc ctgggacatt gcagccgagg tgatcagtca tggctctcga aaaattcttg
    14161 ctctgttttt ctctatcgca gagacagatt cagagactga ttgcacaatt actcatctga
    14221 cagatgagac acgcaaacaa gtcatgaagg tcaagcagaa gctcagcact cgcctacctt
    14281 ccttcatgat accaacagct tggatccctc tgtcgaggat accactttct gcatcgaaga
    14341 aaacagaccg gcgtcgaatg cgtgttcttg tggataaact tccagtggaa caattcaata
    14401 aacacctcat tgatgagaga gtttcaacag gacatggttc taatggttcc gtacatattg
    14461 atgagagacc aatgaccgag gaagagatca tgctgcatga cctcatctgc gaagtgctcg
    14521 aaagccagga ctacgagctt gacaaaagca ctgttaccat ggatcagcaa ttcacagata
    14581 ttggaggcga ctcattgact gcattggctt tggtgtcacg ggcgaagaag atcggatttg
    14641 cttttacagc agcggacgta attgcgtgta ctttgggaga gttggcaggt aagagagttt
    14701 gaaggctaac ttgtatctat gcttatttct tcaattgagt ttcgtcatgt tcgagttgaa
    14761 cgcacagcct gaaaactttc ggttaaatct gagctttgag tagatacccc ctatcataga
    14821 cgacagaaac aatgaacagg ccaaaagtct agctcagctt ggcttcacgt ttttctccac
    14881 cttcggagtt ttcacaaact tcccgttgca ttcccttgct tctaatcaac aatccattct
    14941 catcaaaatc caaaatatga acatcatcca gtagaccccc gccaaatcgt ccggtaaccc
    15001 gagaatagac ccacacctgt agaccctccg cgatcactcg ttgaatttga acattgaaac
    15061 ccggactgtc ggccagaacc tggggccaaa agtcaataaa ttcagacttt gacatcggag
    15121 gtagatcatc gtgtcttagt tcgagatccg ggtggaggat ggaggcaatg gaggatgttt
    15181 cacgcttatt gacgatagta ttgaggaaga gttgagcacg agatttgagg tccatgtttg
    15241 cttagagaga tcttgtggta gagagtgatg tatgggagac agatgttcca agctttgaag
    15301 gagtcgaaat ttgaaatact tgtggttatc ggatatgaca ggggatctgc aactgtcata
    15361 gggtagacgg gaccagggta accggcatgc agctgtaatt gacgtgtagg agatctgcat
    15421 gacgtgtatc cctaaattcc acgcatgtga gagcccgttg cgaaagaccc ctgttcgaac
    15481 accttctttt attatggttt cgtcccgtga attaaatcta ccatgatcta ctcatctatc
    15541 acagaaagaa gcagcgagca tacctgtttt ccacaatgac aatgtatacc aatccccacc
    15601 aagagccgct tgccattgtt ggcatggcat gcaagtatgc tggttccatt gattccccct
    15661 ctgatctgca cgagcaggtc ttagccgctc gttgcatgca gggcccaatg ccttcatctc
    15721 gcatggacgc tgcgttttac caccatccga actccgaagc aactggcacc acgtacacga
    15781 aaggtggata ctttctagac agggatgtga attcgttcga tgcgccattc ttccaattgt
    15841 ctgagctgga tgtgctagcg atggatcctc agcagaagat gttgttggag aatgtctatc
    15901 acgcacttga aaatggtata ttcatcgcca tcgcgatatc aacccttcct cgcgaccgaa
    15961 ttgctgacca agtatagccg gaatcccatt aaaggaggtc gtatcatcac agacatctgt
    16021 atttgtcgga tgctcgaaca acgatcacct cgcattggcc aatgccgatc tgttgatgtc
    16081 cctcaagggc aaagggaccg ggaccagtcc gtccattctt gccaacagac taagttggtt
    16141 ctacgacttt cgagggacaa gccagacgat cgatactgcg tgctcgagta gtctggtcgc
    16201 atttcatcag gcatgtatgg atgtccggac ggggagatcc ccgatggtaa gcattcctta
    16261 ggaccccttg tctggtcact gctaaaaaca aaccagtcaa tcgtcagtgg cgtcaacctc
    16321 atcgaacatc ctgccgcaac cctctacctc tctaacctcg gcgttctctc tcccgacgga
    16381 cgaagctgga gcttcgacgc cagagcaaat ggatacggac gtggcgaggg tctcggcacc
    16441 gtcatcatca agccactgcg cgccgcccta cgcgacggga accgtattcg agccgttatc
    16501 cgagcatctg gatcgaacca ggacggcaga acaccaggaa ttaccgttcc cagcgtggct
    16561 gcgcaagaac aacttattcg cagtgtttac aaagccgcgg atcttgatcc ctcgcagaca
    16621 ggatatgtcg aggcccacgg tacaggaacc ccggtcggcg acccgttaga ggtacaagcc
    16681 attgtgtcgg ccctgggtag ccaaacccgt gagacgccgc tttatgtcgg gtcggtgaaa
    16741 tcggtcgtcg gtcatctgga aggaggagct ggactggcag gcctcatatc tgctacgctg
    16801 gccgtggaat cgaaaaccgt tccgcctgtg gcgggcctga cgacattgaa cccgcgaatc
    16861 gttcagcgag aagatctgaa atttgcacgg caagcaacgc catggcccag agatgatatt
    16921 cgtcgcgcgt cgatcaattc attcgggttt ggtggtacaa atgcacacgt tgtgctcgat
    16981 gatgcggagg gattcctgaa tcagttcctt ggctctcagt tggcagggac attgcaggtg
    17041 acagatgcct tgtcgagtac gatctcaagg cgcctgtgtg gacctgggaa ggatattgtg
    17101 aaacctttct ccaatggcac tgtgaatgga aatggcatta atggtgtttc tcaccccagt
    17161 tggatcccgg agaatcgtgt ttttgttcta tcggcgtttg atgaagctgg tttagaacga
    17221 aacgccacat ccattatatc gcatcttcaa tcgctgaatt tcgaaggaga catggcaatg
    17281 gaagaagatt tcatgaacga cctgtgtcac acgctgaacg aaaaacgcac aatgttcgac
    17341 tggcgcagct accacgtggc ggacactatc gagaacctgc aaaagtcgct tcagagtgtc
    17401 cgtcccattc gtcgatccgc ggctccgaaa accacccggt tcatatttac gggccaaggt
    17461 gcgaattggg ccggcatggc ccaagacctc atggtatacc cgctattccg acgacggatt
    17521 catgaagctg ccatgtttct gagaggtatc ggttgccagt gggatcttta cggtacgttt
    17581 ttatgttgac cctaatattc aatttactca ggaacaccaa ataaccagag aattagaccg
    17641 aatcacctcc cagcacggtg atctcaacga acccaccttt gcgcaatcct cctgtgtcgc
    17701 cgtgcagatt gccttggtgg acctgctaca tagctggaag gtgactccgt ccacagtagt
    17761 gggacactcg tccggcgaaa ttgcagcagc gtactgtgcc ggaaagatct cacgtcaagc
    17821 agcatggaag gttgcttact gtcgaggtca ggtatgcgca aagcagacac atgaagatgg
    17881 ccgtatgctt gctgcagcta tgcctgcaca agaactagaa agacttatcg ccagggtaaa
    17941 caaaggtcta tctgatggag tccaggtcgg ctgctacaac agccccaaga acctgactct
    18001 gacaggcaga cacgagcaca ttctacgtgt caagggcgaa ttagacgaag cgggtgtgct
    18061 gaatcgtttg cttcccgtca aggtcgcgta tcactcgatc tttatgcgag aagttgcgcc
    18121 agagtaccta gagattcttg gggatctgga atttggtgac aagatcaacc acgattcggg
    18181 cattactatg atatcctcgg ttactggtcg accttctctc gagggagagg ttgagagccc
    18241 ttcatattgg gtggacaatt tggtttcacc tgtccgtttc tcgaatgcga ttctcgcctc
    18301 tatgaaaacc ccggatacag ccggctctgc agaggatgca cttatcgaga tcggaccgca
    18361 ctctaccctc cgaagcgcca tcaacgagac actttcagaa catagtgagc tgcagtccta
    18421 ccagtacggt agtatactca agcgatatga gacaaacgga gccacaattc tccagacctt
    18481 tggcgtgctg gcttgtcagg gccacgagat caacctggtt gccgtgaatg atcgccgaat
    18541 aggacggaag agaaccgcga aaatccttcg ggatttgccc ccttacgcat ttgaccactc
    18601 tcggtctgtc cgtggtcaga cacggaaaat cgaacacatc aagttcccag cgtacaaacg
    18661 tcacgagctt cttggtgtgc cggtcgaaga cacaaacaca ttcgaacagc gatggaggaa
    18721 cattctgaga cctgatgata tcacatggct gcgcatgaat agggtgagtt aatacgcagg
    18781 attgtggacg cagctaacat tatgcagatg tcagggaaca tccattttcc cggagttgcc
    18841 tatctcttga tggcaatgga agctgtcctt cagcgcgctg gagaattcga ctctgttact
    18901 ggggtcaggt taggcaacgt gtctatgttg gctccgctgc ctgttccaga cacgccggaa
    18961 ggtgtcgaaa tcatctcctc gatctaccca atggacgcgt cagccagggg cgcagacgac
    19021 tggtgcacct tcagaattat ctcgcatgat gctgctgaaa gatcatggat cgagcattgt
    19081 gttggatcag tccgtataga gaccgcttcg cagaaagctt ctacccatct cttgaacgat
    19141 ggattcttgt caacctgcct cgaaactgtc gatgtcgacc aaatgtatcg gggctttgcc
    19201 tctgcaggta tggattttgg agaattcttg aggaacattc aaggcatgaa gctttccgca
    19261 gaccataaag cctgcacagc aacaattgcg accccagata tcccgaagac agctcatgat
    19321 ggatatgcta ttcatccctg cacgttcgag agcatcctgc acgccctact acatctttgc
    19381 aaagccacgg gtagtcccat ggtaacaaac tacatcgaag aggtctttat ttcttctcca
    19441 tctcccaaaa gccaccctga gtttcaggtt tcagctcaaa cggagaggac ctcttccaca
    19501 acctggaagt ctgacgtgat gatcactgct gagcatgggg gaccggagat cgctatcaag
    19561 ggtctggatt tagtccaact tccgccgaca gagaccgact cgtcagaggc cgaatcgttc
    19621 tacgtggtga aatggaagcc ggatgttcat cttgccactt cagctaagtc tctacgggac
    19681 tccgctccgg ttgaggtaaa ccaacgtctt ccgagcttcg atgatcacga ggggttccaa
    19741 cttgcttcag ccattttcct ccttgacaca atggactaca tcgaacagga aggacttcca
    19801 tctctcccgg cccatcacaa agctttcatg aagtggatgc agcaggaatg tgaattgatc
    19861 aacgaatcat catccccgtt ggttgacaaa gccttgatga acgggattcg cgagagtcca
    19921 tctcgacgca agcagttgtt cgaccaagtg gccaaccaaa gcgcgcgagg cgaactccta
    19981 gtccgggttg gcttgcaaat gatacccatt ctggagcaaa aggtcgactg cctggatatc
    20041 atgtttggag aggatgacct catggatcga acgtacgagg aaggtcttcc tggtgacatc
    20101 gcttctgcgg tcgcaggcta cgtgcattgc cttgctcata gccgtacgga cctcaagatc
    20161 cttgaggtcg gtgccggtac cggcagcgcg acgaaggtga ttctggacag cctaatgccc
    20221 acggctagac tggacggagg aggtcttgtg tcgtctgtct cgacgtatca ctttacggat
    20281 atatcggcgg cgttttttga gaatgcaacc aagcggtttc cggactgggc gggcattttg
    20341 cgtccacagg tattgaacat tgagaaagat cccgctgacc agggcttcga gcttggatct
    20401 tatgatctag tgattgccac acatgtacga cttcgggtcc ccctgtctac ccagtgttga
    20461 ttattaacat ggcataggtt cttcatgcaa cggccgacct taatgtctgt ttgagcaatg
    20521 ttaaaagcct gctgaaagag taagtctcga atccattgct tgatgtgcga aatctaaagt
    20581 tatcagtggc ggtgatctca ttgtgatcga aaatatcaaa cccgaactga tgtgctcgcc
    20641 tctcgggttt ggtttgctcc caggatggtg gcgtagcgtg gagccctatc ggcagttgaa
    20701 tcctttgatt gacgaagatc aatggcaaga ggagttgcac aatgcaggtc ttcatccccg
    20761 gctactgatc aaagacacgg acgaccaggt caatgaaatg tctgccttcg tggcagcgaa
    20821 agtaccatca gccccttcta cgaaacgtct cttcagcata atctactcgt ctacctatcc
    20881 gggacaatat gatctagctc gcaagatcgc ggaacagatg acttcgaaaa catgcactgc
    20941 agttccagta gacctggtcg atgtttcgcc tgatcacacc aactcaattg gaattgttct
    21001 actcggctac cgaggtttag acctctctgc gctgtcgagc tctgagttcg acgaaattca
    21061 atatatccta ggcgctttca ccaacctgtt gtgggttacc tgcgacttgg acgagacacc
    21121 aaagtctgct atgtccacag gccttgttcg cacagcgcgc tgggagaggg atcatgacgg
    21181 cattaatttt ctcatgctcg aaatcaagca acaaacgact gagtggcagg acattctctt
    21241 gagtatcact cgtgtgtgcg accgtgcgtt cacctctgag gcgcttgtgc ctcgcaacgc
    21301 agagtatcgc ctacaagatg gcattatcct caccaaccgc ttgttcccag cctcgggaat
    21361 caacgagtgt atcaattcgg ggtcgaaatc acggtctaag ctagtcgatc tggaacacgt
    21421 cacacacccc gtcaagctga catccattgg ctctcatcaa ccgaacggct ttcactttgt
    21481 tgagaatgaa gaccatcaac agcctttgca tccgcatgag gttctaattg aagtgcacgc
    21541 tgtaggtctc gacgagcatg acgctgaccg attcacccgc tcgatcccag gggagaccct
    21601 tggctcgcag ggagcgggcg tcgttgtcag ccttggggac gctgtacaag atcttcaagt
    21661 tggcgatgct gtcatggcgc tgcgcacttc ggatggcacc tttcaatcat tcttccgcgc
    21721 ccattctgct gctgttgtca aaatgccaac cagcataagc ttcactaagg ccgctgcact
    21781 tccagtcgca ttttcgacag catatcacgg cctagtcaat gtcgctagag tgcagagtga
    21841 agacaaagtg ctcattcacc acgcggctgg aagcatcgga cacgctgccg tgcaagtcgc
    21901 tcgatccctt gatgctacta tttactgcac ggtgtcaaac gattctcaac gacaaatttt
    21961 acttgaaaca ggcattcctc caaaccacgt gctcgacgca aattcttgga caacggagct
    22021 ttctaacatc gccaaaggtg atgtggatgt cattctcaat ctgagttccc ggggtatcga
    22081 aagcaaagat ctggcttgtc tctcttcttt cggacatcta attgaccttc acgggcaagg
    22141 tgttctcgga cctgtggccg cttccactac aaacaggacc tactccagcg ttgatattcg
    22201 gtctctggcc cttcaaaagc cgagagcagt tcaagacaca ctccgcaata tatcacgact
    22261 cttggccgag cagaatattc ggcctatctc accaacagtt ctcggatttt cagggctccc
    22321 aaatgccttg gcagaaatcc gtcaaggttc cctcggccct tgggcttttg agccacggcc
    22381 tatggatacc atacctgtat gtctatcctc tctattacct tgtcgagcgt tctctttact
    22441 aacgttttta gattgcgatt aaaccactag gatatcacac atttgactcg aatgcatcat
    22501 acgtccttgt cggcggtttc ggaggtatag gccggagcgt cactcgatgg atggtaactc
    22561 gtggcgcgag aaacttcatt ttcgtctcac ggtcaggcgc cagcagtcct gctgctcagg
    22621 agctatacat ggaactactg gcttcaggct gcagcgtatc ggacctggtg tgcgatgtga
    22681 ccaacaaaga agcagtggcg caggcgatca acagctgtca ggcagaaatg cctccgatta
    22741 aaggatgtat gcaatgctcc atggtcctcg aggtacgtct cccagttcag aactataccc
    22801 ccaacgcagc gcaaccagct aaccagcacc ccaggactcc atgctcagca acatgtccca
    22861 cacacagttc ctctccgcca tcacccccaa agtccaagga acaatcaaca tcgcctctgc
    22921 gctctccagc tccccccttg acttcctcat cctcctctcc tcatccgccg gaatcatcgg
    22981 caaccgcggt caggccaact actccgccgc caacgccttc ctggacgctt tcgccgcctc
    23041 tctcgtccaa aagggatacc ccgctacctc catcagtctc ggcagcgttc tctccgtcgg
    23101 ctgggtcgcc gagaaccaag accgcctgcc catcgcactc tcctacggcg ccatctccga
    23161 atccctcctc ctctccatcc tcgaatacca tatggatccg cggtggtgcg ccgcccaaag
    23221 cccggacaca tgccataccg ttgcgggcgt ccgctcggcg aaggacttcc atcgcatgtc
    23281 catcccgttg cccgggttca tggcgtatcc gctgttctcg ccgctgcgcg caatcgccag
    23341 ttcctctggg gccgggaaag aagaggcaga ggtgccagtg atgcaggcgc ttagggctgt
    23401 acgctcggtc cctgccgcgg tggaggttgt tacgaaggct attgtgatga agttggctcg
    23461 tgtcatggcg atctcggcga aggagatcga tccggcgagg acgttggcgt cgtatggtgt
    23521 tgattcgttg gtcacggttg atttgaaagc gtggtttaag agagatgttg gggtgaatgt
    23581 tgcgtcgggg gatctgttgg gtgatgtttc gatgcaaggg ttggcggaga agatggctgg
    23641 gtcgagtgag tttctgtcgc ttgggaagta g
//
