LOCUS       BGC0002616             23320 bp    DNA     linear   PLN 16-DEC-2016
DEFINITION  Penicillium roqueforti strain PTX.PR.27 mycophenolic acid
            biosynthesis gene cluster, partial sequence.
ACCESSION   BGC0002616
VERSION     BGC0002616
KEYWORDS    .
SOURCE      Penicillium roqueforti
  ORGANISM  Penicillium roqueforti
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Penicillium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 18:05:50
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 23320
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            <1..>1479
                     /gene="mpaH"
     mRNA            join(<1..192,445..>1479)
                     /gene="mpaH"
                     /product="putative hydrolase"
     CDS             join(1..192,445..1479)
                     /codon_start=1
                     /gene="mpaH"
                     /product="putative hydrolase"
                     /protein_id="API82667.1"
                     /transl_table=11
                     /translation="MSSEKFTVTEHLVPGSYIREYPGSTVMQEDVLKIHVKQYTPKHEG
                     PVPADAITFIAAHGVGLPKMDHPRDLFLMINHFREQMPRPLVGVGHSFGGNIMFVTNNP
                     LNFENSKNEILISFSSTNLAYLHPRLFTTLLLIDPLIQLSPPSMGFGTDPPGPINYTLW
                     RNDVWPSREAAIRANRGLIHGWDPRCVDRMAKYFFRDLPTPLYPDVEAVKARFDAAADT
                     TATPVTLATPKYHELIAQIRQNFNARDPTTGRIEIPRATHADMDPLVASIPLYRPEPRS
                     TFRRLGTLRPSCLWIVGGATFLNVDEIHEGVKICGSGIGGSGGVSEGRVKEVILPGLGH
                     LMPFQEIGTVVGPCVAWLQQEMNRFRQMEREWEEERKGKSHLVLEENWYKVLKPMPSGR
                     GKGGRKEKL"
     source          1..23320
                     /db_xref="taxon:5082"
                     /mol_type="genomic DNA"
                     /organism="Penicillium roqueforti"
                     /strain="PTX.PR.27"
     misc_feature    <1..>23320
                     /note="mycophenolic acid biosynthesis gene cluster"
     protocluster    1..23320
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[11689:19446]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      11690..19446
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..23320
                     /SMILES="CC(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..23320
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002616"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..23320
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            <2509..>3758
                     /gene="mpaG"
     mRNA            join(<2509..2676,2772..>3758)
                     /gene="mpaG"
                     /product="putative O-methyltransferase"
     CDS             join(2509..2676,2772..3758)
                     /codon_start=1
                     /gene="mpaG"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 152.7; E-value:
                     2.5e-46)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative O-methyltransferase"
                     /protein_id="API82668.1"
                     /transl_table=11
                     /translation="MLTKSVTSILQGITLAAKEFENNEAGARESLIAHSRALISALEVP
                     SEFIQHTFWSQMFQHLKDAAGKGIDCEALSMKTGVDASLLSRLARHLVAMNVITFQNGA
                     FHGTDLSDSLAAENYQHSIRFCHDVSRPSFNEFPEFFKSNGYKTPTLSGTDGPFQAAHK
                     TELTFLQWLVNTPPYLQYFHSYMSVYRAGKPNWCDTGFYPVSERLLSGFDASVSDVVLV
                     DVGGGRGHDLETFASKFSPLPGRLVLQDREQTIASMPADESRQFEATAHNIFTPQPVKY
                     ARAYYMHSVPHGFGDEDAIKIMTNLVPALAKGYSRVLLNEIVVSEENPILAATNMDMIM
                     LAHLAVKERTEAEWRYIFTQAGLKVVNIYSYPGVAESLIEAELA"
     gene            <4341..>6048
                     /gene="mpaF"
     mRNA            join(<4341..4484,4618..4845,5014..>6048)
                     /gene="mpaF"
                     /product="putative inosine monophosphate dehydrogenase"
     CDS             join(4341..4484,4618..4845,5014..6048)
                     /codon_start=1
                     /gene="mpaF"
                     /product="putative inosine monophosphate dehydrogenase"
                     /protein_id="API82669.1"
                     /transl_table=11
                     /translation="MVEILDYTKALEVLKEYPGDGLHVDTLLDSDSHGALTYNDFLILP
                     GSIMDTVTEHSMAIHMALLGGLGVIHNNCPPDEQAEMVRKVKRYENGFIQDPIVLSPET
                     TVGEAKELKTKWGFGGFPVTMATDLVTAPAGTTLAEANEVLRSSKKGKLPIVDKDGSLI
                     SLLSRSDLMKNIHYPLASKLPSKQLLCAAAISTHDADKVRLQKLVDAGLDIVVVDSSQG
                     HSTFQIAMIKYIKQNFPDIDVIGGNIVTREQAAALIAAGADGLRIGMGSGSACITQEVM
                     AAGRPQAAAVRSVSAFAARFGVPTIADGGVQNLGHIVKGLALGASAVMMGSLLAGTTES
                     PGEYFMSSEGQLVKAFRGMGSIAVMEDKSKSGAGNNAGASRYFSENDKVKVAQGVAGSV
                     IDRGSITQYVPYLVAGVQHSLQDIGVQNLDALREGVNNGTVRFEMRSASAQTEGNVHGL
                     HTHEKKLYSS"
     gene            complement(<6288..>9997)
                     /gene="mpaDE"
     mRNA            complement(join(<6288..7073,7689..8108,8204..8416,
                     8479..8799,8922..9299,9896..>9997))
                     /gene="mpaDE"
                     /product="putative P450 monooxygenase and putative
                     metallo-beta-lactamase superfamily II"
     CDS             complement(join(6288..7073,7689..8108,8204..8416,
                     8479..8799,8922..9299,9896..9997))
                     /codon_start=1
                     /gene="mpaDE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 197.3; E-value: 7.8e-60)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative P450 monooxygenase and putative
                     metallo-beta-lactamase superfamily II"
                     /protein_id="API82670.1"
                     /sec_met_domain="p450 (E-value: 6.8e-35, bitscore: 109.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVEAGGDMRDKLMWIRLYILGNVGQTFGDMKRYRRLISILKVYF
                     IFILNPPAQVYVQDINLYTMDYLIIIRITAVAVVLYLTRYVCCLYLHLQDVPGPLFAKF
                     TNLQRVWWVKSGRAHEYHRRMHAVYGPAVRFGPNMVSISDPRTIPAIYPSRPGFPKMPA
                     VFNSQDEDLHKRLRSPIAPLYSMTNVVKLESFVDQTLAVLLEQLDGRFLGSNDVPFDLG
                     SWLQYFAFDSMGTLTFSRRYGFLEQGRDMNGILGEIWKFMKRVSVMGQIPWFDEFCNTN
                     PFIALFRSPTGFGVLKVVDKFILQRLAPREKDEVSDEKDMLSQFLNIQASNPDVMPWMA
                     GSDSTANVMRTIMYNLLVHRDTLSRLQDELLESESSNGLSRTCPSWEKVRDLPYLDACV
                     LEALRLHPPFCLPFERVVPGGGLTVCETYLPAGTIVGISPYMANRDKETFGNDADEWRP
                     ERWLGLSHEDRKRLENSLLTMIKSQTTIQNPRNISDILDSDASSLGIRSTDIEAIIWSH
                     AHFDHIGDPSTFPLSTELVVGPGIRDSHWPGFPTNPDAINLNSDIQGRKVREISFERTE
                     KEAIKIGSFDALDYFGDGSFYLLNAAGHSIGHIGALARVTTSPDSFVFMGGDSCHHAGV
                     LRPSKYLPCPSHSRHIPLSSESESVFTLSPVLPSDYDAALKTVDNIKELDAYDNVFLIL
                     AHDSTLKGNMDFYPLTINDWKAKGYGKQTKWLFYKDLEDAMEGTK"
     gene            <11690..>19446
                     /gene="mpaC"
     mRNA            join(<11690..12328,12563..13489,14015..18436,18517..>19446)
                     /gene="mpaC"
                     /product="putative polyketide synthase"
     CDS             join(11690..12328,12563..13489,14015..18436,18517..19446)
                     /NRPS_PKS="Domain: SAT (14-178). E-value: 1.8e-09. Score:
                     29.4. Matches aSDomain: nrpspksdomains_mpaC_SAT.1"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (347-637). E-value:
                     5.3e-55. Score: 178.8. Matches aSDomain:
                     nrpspksdomains_mpaC_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (747-1037). E-value: 1.5e-56.
                     Score: 183.8. Matches aSDomain:
                     nrpspksdomains_mpaC_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (1151-1249). E-value: 2.2e-14.
                     Score: 46.0. Matches aSDomain:
                     nrpspksdomains_mpaC_PKS_DH.1"
                     /NRPS_PKS="Domain: PP-binding (1472-1538). E-value:
                     4.8e-13. Score: 41.4. Matches aSDomain:
                     nrpspksdomains_mpaC_PP-binding.1"
                     /NRPS_PKS="Domain: cMT (1741-1932). E-value: 3e-64. Score:
                     208.5. Matches aSDomain: nrpspksdomains_mpaC_cMT.1"
                     /codon_start=1
                     /gene="mpaC"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     hyb_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     tra_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066:alpha/beta hydrolase domain-containing protein
                     (Score: 63.6; E-value: 2.7e-19)"
                     /gene_kind="biosynthetic"
                     /product="putative polyketide synthase"
                     /protein_id="API82671.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.3e-51, bitscore:
                     164.5, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="mod_KS (E-value: 6.2e-50, bitscore: 159.1,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 1.6e-50, bitscore: 161.0,
                     seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 1.3e-57, bitscore: 184.4,
                     seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 8.1e-53, bitscore: 168.6,
                     seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_KS (E-value: 6.6e-56, bitscore: 178.8,
                     seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.9e-57, bitscore: 183.8,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 6e-14, bitscore:
                     41.4, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 1e-10, bitscore:
                     30.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLNTEHSKGDLRLLFGPQCSEIEDSIAHIRDAVYKDSAGLGFLS
                     DILDELPSLWPVITSAWPALRKVQGEKQLAALGRRFENGSPDSEAEPSSLIMTPVTVMK
                     HLVDFWNLQNVATHPAFPSSPLSRTTAPRIIDSQGFCVGILAAIAVACSQDTREFQSLA
                     SNAIRLAVCIGALVDFDEIVSGKAKSIAVRWETPADHDYLEQTLTKSPNVMNLCVKDPR
                     FQLPHSNALILPLRSSHNGQVLINAAMLHTVALESILSVKADWWGTVSALLNSADMEVD
                     ESRLLSIGQEEFVPRSARGRLVARSNLDVYGAGVFANGNTSARSAVSLQNGTNTLNGSP
                     QAAEMPPIAITGMACRYSNADTTSELWDLLELGVCTVEKAPGNRFRMPDLQREPKGPFW
                     GHFLDRPDAFDHRFFNISAREAESMDPQQRVLLQVAYEAMESAGYCGWQHTELSDEIGC
                     YVGVGSEDYTENVASRNANAFSATGTLQSFIAGRISHHFGWSGPSITLDTACSSAAVAI
                     HMACKGTQVGDPIELESLRKAFGNPLRSQSLHVGSIKGNIGHTETSSGVAGLLKTILML
                     QKQRIPKQANFRQLNPKVMPPLENDRLVIPVESTKWASARRVAMVSNYGASGSNAALIV
                     RDHTPSLSGQGKAMAEYIRDMPILISARSEESIRAYCGALRTTLLRHPYSNTVVRELAY
                     NVAMKQNRTLPFTLTFSTSSDPTSLSTRLEAIAAGKSADIIQKRESNEPPIVLCFGGQN
                     GVTSSISQELYDSCVLLQTHLMACEQAGQKLGLPSLFPTIFTSDPIVNTVYLHFMLFSI
                     QYASARAWIDSGLRVDRIVGHSFGQLTALSVAGSLSVQEGIRLVTERARLIQSNWGPES
                     GVMLAVEGTQAEVQRVLEQTGHRAEIACYNGPQQQVLAGTGECIRAVEDALATNPLTSN
                     VRVRRLENSHAFHSRLVDSIVPGLTELAESFVYQAPAIPIEACSATGDWSIVTPAKIVE
                     HSRMPVHFQRAVERIAQKLQVPAVWLEAGSASPIIPMVRRVLEKSSATHTYHRVNLDGS
                     DGSGNLATVTSALWGQGVHVQFWPFHHSQRGTFGWMNLPPYQFAKNRHWVDFDPTAFSF
                     SGSSAEPQCGSQERAGLLRKLSDGPEEYLFAVNTQDVLYRSCTKGHAVLDQTLCPASMY
                     MEMVLRAATSVFTLGESSTLTMSHIEDLVISSPLVLDPQGSVFVRLIPEAVASSQTWSF
                     SIFSSSGTGNESSIHATGSVSLCNERSRALSHFQSMNRLMDPARARGIEDHLASNGLKG
                     STVYSALEQVTNYADYFRGVRQVFANGREAAGLVSMAPSATETTCNPILLDNFLQVAGI
                     HVNCLSGREAEEVFVCNAIGETYVSDSLFKKEDGAIPLSWKVYTNYVRPSKNEIVCDIY
                     VMNSQGDGLTAAIMGVRFMSVSIRSLTRALAKLNNNFPDVPQLPPTIQPAIVTADYDEA
                     SDNVNVDSDLVAVQEMLCELFGVSVEEVSPSVSLIDIGVDSLISTEVLSEIKRRFHKDI
                     SYSTLVDIPNIQGLTEHIFPGHSHLAPSQIVIKPVRQQTVIPQTVTXLPVPANAGPSLV
                     SVAHQCFYETHAAVSHTHNADWAGFFNAIYPQQMTLITAYILEAFRALGSPLESSQADE
                     VLPIISVLPRHEQLKKHLYTILESVNLVRQTPTGQLVRTATPISPLSSHALHAQIRDEH
                     PPYALEHDLLQITGSRLAECLTGQADGVSLIFQDSQTRRLVGDVYTDSPVFKSGNLYLA
                     QYLTDVIQTLGNGRQVKILEIGAGTGGTTKNLLEQLSALPGMATRMEYTFTDISPSLVA
                     AARKKFSKYDFVRYETINVESSPPSLLHGQYDIVLSTNCVHATRNLVESCSNIRKLLRP
                     DGILCLVELTRDIFWLDLVFGLLEGWWRFEDGRKHALATEDLWDQTLRQSGFEWVGWTN
                     NEAVESNALRVIVASPTKAPSALEICSKPANMETVVWGERNGLQLLADIFYPDVVDTTQ
                     KRRAMVHGGGHVMLSRKDIRPAQTQTLLDAGFLPISVDYRLCPEVSLSEGPMADVRDAL
                     GWVRRILPNIPLLRPDIRPDGNQVVAIGWSTGGHLAMTLAFTAPAVGIAAPEAILAFYC
                     PTDYEDPFWSRPNFPFGQTVASNDIEYDVWEGVQSAPIKGYNPAFKERPLGGWMSTSDP
                     RSRIALHMNWTGQTLPVLLGGMHKEFRIPDELPRPTDEEIQAVSPNYQIRIGRYRTPTF
                     MVHGTSDDLVPCAQTESTYNALTQNGIEADIRVVQGAVHLFDLYPSSHAGQNAKEAVAD
                     GYEFLKRHIHSKGYSDKD"
     aSDomain        11732..12223
                     /aSDomain="SAT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mpaC_SAT.1"
                     /evalue="1.80E-09"
                     /label="mpaC_SAT.1"
                     /locus_tag="mpaC"
                     /protein_end="178"
                     /protein_start="14"
                     /score="29.4"
                     /tool="antismash"
                     /translation="LFGPQCSEIEDSIAHIRDAVYKDSAGLGFLSDILDELPSLWPVIT
                     SAWPALRKVQGEKQLAALGRRFENGSPDSEAEPSSLIMTPVTVMKHLVDFWNLQNVATH
                     PAFPSSPLSRTTAPRIIDSQGFCVGILAAIAVACSQDTREFQSLASNAIRLAVCIGALV
                     D"
     aSDomain        join(12965..13489,14015..14359)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mpaC_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="5.30E-55"
                     /label="mpaC_PKS_KS.1"
                     /locus_tag="mpaC"
                     /protein_end="637"
                     /protein_start="347"
                     /score="178.8"
                     /tool="antismash"
                     /translation="IAITGMACRYSNADTTSELWDLLELGVCTVEKAPGNRFRMPDLQR
                     EPKGPFWGHFLDRPDAFDHRFFNISAREAESMDPQQRVLLQVAYEAMESAGYCGWQHTE
                     LSDEIGCYVGVGSEDYTENVASRNANAFSATGTLQSFIAGRISHHFGWSGPSITLDTAC
                     SSAAVAIHMACKGTQVGDPIELESLRKAFGNPLRSQSLHVGSIKGNIGHTETSSGVAGL
                     LKTILMLQKQRIPKQANFRQLNPKVMPPLENDRLVIPVESTKWASARRVAMVSNYGASG
                     SNAALIVRD"
     aSModule        12965..17062
                     /complete
                     /domains="nrpspksdomains_mpaC_PKS_KS.1"
                     /domains="nrpspksdomains_mpaC_PKS_AT.1"
                     /domains="nrpspksdomains_mpaC_PKS_DH.1"
                     /domains="nrpspksdomains_mpaC_PP-binding.1"
                     /iterative
                     /locus_tags="mpaC"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       13424..13471
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mpaC_0001"
                     /evalue="5.60E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="mpaC"
                     /protein_end="516"
                     /protein_start="500"
                     /score="15.4"
                     /tool="antismash"
                     /translation="GPSITLDTACSSAAVA"
     aSDomain        14690..15559
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mpaC_PKS_AT.1"
                     /evalue="1.50E-56"
                     /label="mpaC_PKS_AT.1"
                     /locus_tag="mpaC"
                     /protein_end="1037"
                     /protein_start="747"
                     /score="183.8"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="CFGGQNGVTSSISQELYDSCVLLQTHLMACEQAGQKLGLPSLFPT
                     IFTSDPIVNTVYLHFMLFSIQYASARAWIDSGLRVDRIVGHSFGQLTALSVAGSLSVQE
                     GIRLVTERARLIQSNWGPESGVMLAVEGTQAEVQRVLEQTGHRAEIACYNGPQQQVLAG
                     TGECIRAVEDALATNPLTSNVRVRRLENSHAFHSRLVDSIVPGLTELAESFVYQAPAIP
                     IEACSATGDWSIVTPAKIVEHSRMPVHFQRAVERIAQKLQVPAVWLEAGSASPIIPMVR
                     RVLEKSSAT"
     CDS_motif       14936..15040
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mpaC_0002"
                     /evalue="5.70E-13"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="mpaC"
                     /protein_end="864"
                     /protein_start="829"
                     /score="40.9"
                     /tool="antismash"
                     /translation="IVGHSFGQLTALSVAGSLSVQEGIRLVTERARLIQ"
     aSDomain        15902..16195
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mpaC_PKS_DH.1"
                     /evalue="2.20E-14"
                     /label="mpaC_PKS_DH.1"
                     /locus_tag="mpaC"
                     /protein_end="1249"
                     /protein_start="1151"
                     /score="46.0"
                     /tool="antismash"
                     /translation="GHAVLDQTLCPASMYMEMVLRAATSVFTLGESSTLTMSHIEDLVI
                     SSPLVLDPQGSVFVRLIPEAVASSQTWSFSIFSSSGTGNESSIHATGSVSLCN"
     aSDomain        16865..17062
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mpaC_PP-binding.1"
                     /evalue="4.80E-13"
                     /label="mpaC_PP-binding.1"
                     /locus_tag="mpaC"
                     /protein_end="1538"
                     /protein_start="1472"
                     /score="41.4"
                     /tool="antismash"
                     /translation="AVQEMLCELFGVSVEEVSPSVSLIDIGVDSLISTEVLSEIKRRFH
                     KDISYSTLVDIPNIQGLTEHI"
     aSDomain        17672..18244
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mpaC_cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="3.00E-64"
                     /label="mpaC_cMT.1"
                     /locus_tag="mpaC"
                     /protein_end="1932"
                     /protein_start="1741"
                     /score="208.5"
                     /tool="antismash"
                     /translation="YTDSPVFKSGNLYLAQYLTDVIQTLGNGRQVKILEIGAGTGGTTK
                     NLLEQLSALPGMATRMEYTFTDISPSLVAAARKKFSKYDFVRYETINVESSPPSLLHGQ
                     YDIVLSTNCVHATRNLVESCSNIRKLLRPDGILCLVELTRDIFWLDLVFGLLEGWWRFE
                     DGRKHALATEDLWDQTLRQSGFEWVGWT"
     CDS_motif       18760..18801
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mpaC_0003"
                     /evalue="9.20E-03"
                     /label="NRPS-te1"
                     /locus_tag="mpaC"
                     /protein_end="2091"
                     /protein_start="2077"
                     /score="8.7"
                     /tool="antismash"
                     /translation="IGWSTGGHLAMTLA"
     gap             19752..20049
                     /estimated_length=298
     gene            complement(<20205..>21153)
                     /gene="mpaB"
     mRNA            complement(join(<20205..20696,20857..>21153))
                     /gene="mpaB"
                     /product="putative dephospho-CoA kinase"
     CDS             complement(join(20205..20696,20857..21153))
                     /codon_start=1
                     /gene="mpaB"
                     /product="putative dephospho-CoA kinase"
                     /protein_id="API82672.1"
                     /transl_table=11
                     /translation="MDKGTSFFTTPSFSATTRAIFNTMPQWFSFAVGLLIAYPLLINSL
                     RYRRLKQLQKKFYFPTRESMAKMTDEEAFQIQKETAQLEFPFMFVKAGQFALFRMVENS
                     PTSQRAFLSVARTRFLHSGYQASGKILDTDLLYTLALFAVQPVNFIAAFEWRPLSDLER
                     CAIGTFWKSLGDALGISSDILPSGKTGFRDGIHWLEEVDTWSQEYEVKYMVPDAQNRES
                     ADQATAVLLYNLPKVFHPVGLQFTSFMMDDRLRKAMLYVE"
     gap             21154..21677
                     /estimated_length=524
     gene            <22195..>23320
                     /gene="mpaA"
     mRNA            join(<22195..22299,22552..22662,22754..>23320)
                     /gene="mpaA"
                     /product="putative prenyl transferase"
     CDS             join(22195..22299,22552..22662,22754..23320)
                     /codon_start=1
                     /gene="mpaA"
                     /product="putative prenyl transferase"
                     /protein_id="API82673.1"
                     /transl_table=11
                     /translation="MVGSMENPGSWGLACLLISTSRFNRYMPYYTMMAAMRPLASGKVS
                     TVEALVWMVGQYFLSVKMLDLILDNRSMLPLTASIMLYPYLKRPVFSRVFIYPQYILGL
                     AVAYPSITGWASINGQEQSMSEIFTHCTPICLLIFFWCLYFNTAYSHQDSVDDRKMNIN
                     SAYVVAGQRIRLFLAFLGALPLAVIPYVVLKINSPWLWFSWMAVWTVSIVMQIVRFDSK
                     KLESGGRIHWDNFLLGLWTTVACIVEVGLQKVEFWNLI"
ORIGIN
        1 atgtcaagcg agaagttcac cgttactgag catcttgtcc cgggcagtta tattagagaa
       61 tacccaggga gcaccgtcat gcaggaagat gtactgaaaa ttcatgtcaa acaatatacc
      121 cccaaacacg aaggtcccgt cccagctgat gcaattactt tcattgccgc tcatggagtc
      181 ggtctcccga aggtgaccct gtctttaacc tgataattcg tctcatgtgc tcaacattgg
      241 acacaggaac tgtacgagcc gctgtgggac gagctgctgg aacgaactaa tggcttccac
      301 attcatggca tctgggtggc cgacgtcgcc agtatgaacc agagcgggat ccagaatgag
      361 gataagctca gtatggattg tatgtgcttc ccattcgatt cttgatacat ctccccccat
      421 attaacaatt tcctaggttc ttggatggat cacccgcgag acctcttctt gatgatcaac
      481 cattttcgtg agcagatgcc acgtcctctc gtcggagttg gccacagttt tggcgggaat
      541 atcatgtttg tgacgaataa ccctctcaat tttgagaatt caaagaatga gatactgatt
      601 tctttttcca gcacaaatct tgcctatcta catccacgcc tgtttacaac cctcctcctt
      661 atcgaccccc tcattcagct aagccctccc tcgatgggct tcggcaccga ccctccaggc
      721 ccgatcaact acactctctg gcgaaatgac gtctggccca gtcgcgaggc agccatacgt
      781 gccaaccgtg gcctcatcca tggctgggat cctcggtgcg tagatcgtat ggcgaaatac
      841 ttctttcgcg atctaccgac accgctgtat ccggatgtcg aggccgtgaa ggcgcgcttt
      901 gatgcagccg ctgatactac tgccactccg gtcaccctag cgacgccgaa gtaccacgag
      961 cttatagcgc aaatacggca gaacttcaat gcccgggacc cgaccacggg ccggatcgaa
     1021 atcccacgag ccacccatgc cgatatggac ccattggtgg catctattcc cttataccga
     1081 ccagaacctc gaagtacgtt ccgccgctta gggacactcc ggccttcatg cctgtggatt
     1141 gtgggcgggg cgacgttttt gaatgtcgat gagattcatg aaggtgtcaa gatatgcggg
     1201 tcaggcatcg gcgggagtgg aggtgtgtct gagggaagag tgaaagaggt tatcttacct
     1261 ggattggggc atttgatgcc atttcaggag attgggactg ttgtagggcc atgtgtggcc
     1321 tggttacagc aggagatgaa tcgattccgg cagatggaga gggagtggga agaagaaagg
     1381 aaaggcaaga gtcatctagt gctagaggag aactggtata aagtcttaaa accaatgcct
     1441 agtggacgtg gtaagggtgg gagaaaggaa aagttgtaga tactagatgg ccaaatgtct
     1501 actttttcaa ttttatgtta tcgaggtatc ctcgtgaatc ccaacaaccc ttgattatcc
     1561 gtctgcatct ccacagatcg cctaacatta gcaatcaagt gaggtctagt gcacacgatt
     1621 gatatgtcgc tggatgtatg ccaaggccag ggtggtcctg gagaaaccca gcagacgaca
     1681 tggcgagatc gacatcctta caataacccc gcttcccaca ccgtttgaat tatatctctc
     1741 attctaacca gaagtttcac atcagctctt tcatataccg tccgtttacc gtatgtaact
     1801 ttatatgtat gttgtagatc ccaaacaaaa cgtacatttt cattggtccg tagcaagggt
     1861 accgaaatgg gggaggttac ccgacatatg catgcaggtg acgttttgat tctaaaacat
     1921 ttgtaatatt gaatagttga ataatagttg aataatagtt ggataatagt tttatatcct
     1981 ttacatgtat ttttacccaa agatacctcg gatcggattt caacgttccg tccgacccaa
     2041 attcgacgga aatttactag gacaggattg gggcgggtga cctagcacca gtcacccgcc
     2101 ttacaccgta ttaccgcccc aatatttaca tgtacataca acatacatgg cccactacat
     2161 ggcccacttg gatggaaatt tcatacatac acgctaaaaa gagcagagat aaaaatcttt
     2221 taatttaaac cccggtcgta ttgtcaaaac tagagaaact tgaaaagtac taggcatcat
     2281 ggcagtaaca acgaggcaga ccaaaaacat ccatggacag cccccaggtt ccacctagcg
     2341 tcgactatac atcgaaagac cccgatttcc gtttaggacg gcatgtgaga ggctttggtg
     2401 tcgccagcca cggctacaaa tataataggt catcttccaa ttttaacatg atattgtgta
     2461 cacctttctc ccatattctc tgagttgaaa tcgttcatca aaagcaccat gctcaccaag
     2521 tctgtgacct ccatcctcca agggattacc ttggcagcca aagaatttga gaacaatgaa
     2581 gctggtgcaa gagaatccct cattgctcat agtagagctc tgatatccgc tcttgaagtt
     2641 ccgagcgagt ttattcaaca cactttctgg tctcaggtaa gcctgatttg gcggggtaag
     2701 actcgaaact attgctgatg ttcatatagc cagcactgtc tgctattatc aggcttgctg
     2761 ctgatgtcaa tatgtttcaa cacttgaaag atgccgcggg taaggggata gattgtgaag
     2821 ctctgtctat gaagacgggc gttgatgcca gccttctatc gcgcttggcc agacacctcg
     2881 tggctatgaa tgtgattacg tttcaaaatg gagcattcca tggcacagac ctgagcgata
     2941 gccttgccgc cgagaactat caacactcca tccgcttttg tcatgatgtg tccaggccct
     3001 cgttcaatga attcccggaa ttcttcaaga gcaatgggta caagaccccg acgctgagtg
     3061 gaactgatgg tccattccaa gctgctcata agactgagct cacctttctg caatggcttg
     3121 tcaacacacc cccctatctg cagtattttc actcttacat gagtgtttac cgtgctggaa
     3181 aaccaaactg gtgcgacacc ggtttctacc ctgtctcaga gcgtctcctt tccgggttcg
     3241 atgcctctgt cagcgatgtt gtgctggtcg atgtgggcgg tggtcggggg cacgacctcg
     3301 agacttttgc ctctaaattc agtcctcttc caggaaggct cgtgcttcag gatcgagaac
     3361 aaaccattgc tagcatgccg gccgatgaat cccgccaatt tgaagcgacg gctcataaca
     3421 tcttcacacc gcagccggtc aaatacgctc gggcgtacta catgcactct gttccccatg
     3481 gcttcggaga cgaggatgca atcaagataa tgacaaacct agtgcctgcg ctggcgaagg
     3541 gatactcccg agttcttttg aatgagattg tcgttagcga ggagaacccc attctagcgg
     3601 caactaatat ggatatgatt atgctggccc acttggcagt gaaggagaga acagaagctg
     3661 aatggagata tatcttcacc caggcgggat taaaggtggt caatatatat tcgtatccag
     3721 gcgtggcgga gagcttgatt gaagcagagc tcgcctaaac gtcaccaatt tctataggtt
     3781 ggctacatat cgaggaaatc agaatcagac tcggaaacaa tataggaaat aaaaacccga
     3841 atcccgaatc ggcaaatcta ggcttcagcc tcggaaggtt agcgcattta aattttcggt
     3901 tctgtggggc cggcggccgc agccctactc cctacggtat cccaagttta agcctgtaac
     3961 aaaaacgcgt tgtttacgga gaagtccgaa ctccgtaggt aaaaatcctt ctgagggatt
     4021 aaaccggtca ttgtgggggt gtagatcatc aaaagaaaga aaacgaaagg cttttcgcta
     4081 aaattcccct gccggagtcc tctttgattg gactacagtg tagtgctgcg atgaaagagg
     4141 gagagagttg tatttccagt tcttgtattt cctgaagttg gtgcctgccg caccggactg
     4201 atggtcaggt gacctccaca tccaacaatc ttaaaaggcc gtccctcccc tgcccctctg
     4261 acttcctttg ggaatcaccc ccccattccc attacctatt agtttttttt ctattttttt
     4321 ttttttttaa aatcagcatc atggtcgaaa ttctggatta taccaaggct ttagaagtac
     4381 tcaaggagta tcctggagat ggcctccacg tcgatactct cctcgattcg gatagtcatg
     4441 gagctttgac ttacaatgac ttcctgattt tgcccggttc tatcagtaag gcaatgaaca
     4501 ttatctcata ggtcgttctc tctaatcgta cgaacagcct tcccggcatc ggatgtttcg
     4561 ttggaaacca gagtaacccg gcggttcacc atcaaggccc ctctactgtc ttctcccatg
     4621 gacactgtga ccgaacacag catggccatc catatggctc tcctgggggg tctgggtgtt
     4681 atccacaata actgcccacc tgacgagcag gctgagatgg tgaggaaggt gaaacgctat
     4741 gagaatggct tcatccagga ccctatcgtt ctgtctccgg agacgacagt tggagaagca
     4801 aaggaattga agactaaatg gggattcggc gggttcccag tgactggtta gttggatttc
     4861 tccttggtgg ctctttttct ttttgtttcg tttggtgatc cttaccttgt ttcgttcata
     4921 gaaaagggaa ccctccactc gaagcttctc ggaatcgtca ccagccgaga tatccagttc
     4981 cacaagaacc acgaggatcc agtcacggct gtcatggcga cagacctcgt caccgcaccg
     5041 gcaggcacta ctctcgccga agccaacgaa gtcctccgga gttcgaagaa gggtaaactg
     5101 ccaattgtgg ataaggatgg atccctgatc tccctgctct cccggagtga cttgatgaag
     5161 aacattcatt accctcttgc atcaaagctt ccatccaagc agctgctctg cgccgcggcc
     5221 attagcactc acgacgcgga taaggtccgt ctccagaagc tcgtcgatgc cggtctggac
     5281 attgtcgtcg tggatagtag ccagggccac agcactttcc aaattgctat gatcaaatat
     5341 atcaagcaga acttccccga cattgacgtt atcggcggta atattgttac ccgtgagcaa
     5401 gccgcggcat tgatcgctgc tggtgcagac ggtcttcgta tcggcatggg cagtggctct
     5461 gcgtgtatca cgcaggaagt catggccgct ggtcgtcctc aggctgcagc cgtacgcagt
     5521 gtatctgcct tcgccgcgcg tttcggtgtt cccactattg ctgacggtgg tgtccagaac
     5581 ctgggccaca tcgtcaaggg acttgccttg ggtgcctcgg cagttatgat gggaagtctg
     5641 cttgctggca ctaccgagtc tcctggtgag tactttatga gcagtgaagg ccagttggtc
     5701 aaggctttcc gtggtatggg cagtattgcg gtcatggagg acaaaagcaa gagcggcgct
     5761 gggaacaacg ccggtgcttc tcggtacttc tctgagaatg ataaggtcaa ggttgcgcag
     5821 ggtgttgcgg gctccgttat tgatcgtggc tctatcaccc agtatgtccc ttaccttgtt
     5881 gctggtgtgc agcattctct ccaggatatt ggtgtccaga accttgatgc cttgcgtgaa
     5941 ggggtgaaca atggaacagt tcgctttgag atgagaagcg ctagcgcgca gaccgagggt
     6001 aatgtccacg gcttgcacac ccacgagaag aagttgtact cttcttgaat gcggcgtctc
     6061 tgttttcgtc gactgttgtc tagagttcct tccatctagt acaccagacc aaaagttagt
     6121 caatacactc tttttgataa tctgccataa gcaaattgtt gtcaagcatt ttgaaaagcc
     6181 tggaatagaa atctagtgat tatacaagat ttaaggggta cagagagctc ttgaagcata
     6241 ttttttcaaa gagtaaggtt tatgaaattc aaaattcaaa cacatctcta cttggtccct
     6301 tccatagcgt cttcaagatc tttgtaaaac agccacttcg tctgcttgcc gtaccctttt
     6361 gccttccaat cattgatagt caaaggataa aagtccatat tccctttcaa ggtactatca
     6421 tgagcaagaa tcagaaatac attgtcgtat gcatcgagct ctttgatatt gtcgactgtc
     6481 ttcagcgccg cgtcgtaatc agaaggaagc acaggcgaca aggtgaaaac ggattctgat
     6541 tcagacgaaa gcggaatgtg acgagagtga gatggacaag gaagatattt ggaaggccga
     6601 agaacaccgg catggtggca ggaatctcca cccatgaata cgaatgagtc cggcgaggtg
     6661 gtaacccgcg cgagggcgcc tatatgacca atggaatggc ctgcggcatt tagaagatag
     6721 aaggatccgt caccgaaata gtccagcgcg tcgaacgagc ctatcttgat ggcttccttt
     6781 tctgtccttt cgaaggagat ttcccgcact ttccgacctt ggatgtccga attgagattg
     6841 atcgcgtccg ggttagttgg gaacccgggc cagtggctgt cccggatgcc aggaccgacg
     6901 acgagctcgg tagacagtgg gaaagtggac gggtcgccga tatggtcaaa atgggcatgc
     6961 gaccagataa tggcttcgat gtctgtgctg cggatgccta gggacgatgc gtcagagtcc
     7021 agaatatccg agatgttgcg cgggttctgg atggttgtct gtgatttgat catggctaca
     7081 acggatggcg gaagtctttc ccagtcctgt cgaactccca agtcaaatag aacatggcga
     7141 gtgccgactg agattaagaa gcagtaagtt ggcgctgtca cctttctaag gcctggcagt
     7201 tcgggttgcc agaatagatc aggtcgtagg tcaaggagtg ttcctctgcg attattaggt
     7261 caattggttc ccatggatac gacgaggtag ggccttacgg gtcgatcact cgcacatcga
     7321 cggtcgatga tgaaggagga atattcaaga caggtggaag agtgggcttg tctttgttac
     7381 tggaacctct ctccattttc gcccgcttgc gaatcactgc ttgtagtccc gtctgcttga
     7441 agaaccaagc attctcggtt ttgtagttct ccgggttgac gatttgtatc tggcacggaa
     7501 caaattagga agagcacata cctgaattga agcaaagtac tcacatcgta gttcaaaagc
     7561 agtaccggaa ttaatttctt gatctcaagg atggcgatat tcttccccag acaagtacga
     7621 cggcccgctc caaactaaat ctcaagatta gtaagagtat gtctgacgta gacgaagtct
     7681 agacccacag tcaacaagct attctccagc ctcttacggt cttcatggct cagacctagc
     7741 catctctcgg gtctccattc gtccgcatca ttaccaaagg tttctttatc ccggttggcc
     7801 atatatgggc tgattccgac aatggtccct gctggaagat atgtctcgca aacagtcaaa
     7861 ccaccgccag gaacaactcg ctcaaaaggt agacaaaatg gaggatgcag ccgtaaagcc
     7921 tccagaacgc acgcgtcgag gtacggcaaa tctctcactt tctcccacga gggacatgta
     7981 cgagaaagac cattactgct ctcagattcc aggagctcat cttgcagacg gctcagcgtg
     8041 tcccgatgaa ctaagagatt atacataatt gtacgcatga catttgcagt cgagtctgag
     8101 ccagccatga tattagagaa agtccaggct cttggggccc tggatatgag ttagccggat
     8161 ataaggcaag agatagaaat cgatcagcgg gaagatttct ttaccaaggc ataacatcag
     8221 ggtttgaggc ctgtatattg agaaactggg agagcatatc cttctcgtct gaaacctcgt
     8281 ctttttcacg aggcgccaag cgctgcaata taaacttgtc gactaccttt aacaccccaa
     8341 accctgtcgg tgacctgaac aatgctataa acgggttcgt attacagaac tcgtcaaacc
     8401 acggaatttg gcccatctga gaaagtcata cgcattagaa accaacggta gcacgacgtg
     8461 cacagagcta gaacccacca cagaaactct cttcataaac ttccaaatct cgcccaagat
     8521 tccattcata tcgcggcctt gttcgaggaa tccatatcgt cgagagaacg tcaatgtccc
     8581 catcgaatca aacgcaaaat actggagcca gctccccaga tcaaacggaa catcgttgct
     8641 gcctaggaac cgaccatcga gctgttccaa cagtaccgcg agggtttgat cgacaaatga
     8701 ctcgagcttc accacatttg tcatggaata tagaggagca attgggcttc gaagcctttt
     8761 atgaaggtcc tcgtcttggg aattgaacac cgccggcatg gcgcccttgt ttggcgtgta
     8821 gggcttctgt gtgcgataaa agtcgctctg ggggtagcga tgttagcgat tgaaatccaa
     8881 tcatgactgc acgcaataac tctggtacta ccatcactga ccttgggaaa cccaggccta
     8941 ctagggtaga tagccgggat ggtgcgagga tccgagatag agaccatgtt tggaccgaat
     9001 cgaacggcag gcccatacac agcatgcatc cgacggtggt attcatgagc tcgtccggac
     9061 tttacccacc acacgcgttg caggtttgtg aactttgcaa acaacggacc tggtacatct
     9121 tgcagatgca agtatagaca acaaacgtag cgggtgagat atagcacaac agcaacagct
     9181 gtgatacgta ttatgatcag atagtccata gtatataagt ttatgtcttg tacgtatact
     9241 tgtgctggag gattgagaat gaaaatgaaa tagactttca agattgagat caatcgtcta
     9301 gtatctatta accgaatcat attgctattg atagaacaac aagctattgg cctaaaggga
     9361 cagagtacat ttgcacacac ctcgcctctt tacacagctg gattgagttc gtatcaatac
     9421 agtttatgga aattagatat ttcgtaatct ataggcagtt gcctaatttg tgccttagtg
     9481 catctccacc tccaaatcta gaatgctccc acatatagcc ccgcgctact gcgtacacct
     9541 cacgcgaatc gggtctatac ataataacac tccacaaaaa gtgaagcgga ctaccccgcg
     9601 tataatataa catgtgcgtg acattcaagc ctttgcatat cttactgcat tgtatacctg
     9661 ctccactcga attcgatatc gattgttcgg gcgatcgtaa taggatgacg gctggctgcc
     9721 cggtgtaggc atcttagtct acacctgcat atgggttcaa gtcgataaga ctcaataggt
     9781 agcccgacgg ggttacgtac gctttgtgct gatcgggaat aacataccac tccacatccc
     9841 actccgcaaa ttatccatag gtgaaataag tactagagcg gcatacttct tacatgtaac
     9901 gcttcatatc gccaaaagtc tggcctacat tgccaagaat atacaatcgg atccacatta
     9961 acttatcgcg catatcgccc ccggcctcaa cgcgcatnnn nnnnnnnnnn nnnnnnnnnn
    10021 nnttagaaag cagataggat ctcccagaat taacagaatg aattgatttg caatcgctct
    10081 tctaccttta cgaaagtatc ctagataaaa aacacgaaat atatgcggtg tatacgggat
    10141 cctaccagtg aacaagtaaa gggcagtata tattaagaat ggcgcccata gagcgttttt
    10201 ggttcgtatt tccgcactat tgacaatccg aaagggacac ctggcgccga caggggaggc
    10261 cgaatagagc aaattcaagg aagtggcgaa ggaaggactt tttgcgacat tacatcaact
    10321 ctacaaggtt tattccaagg ttgctaccgc gtcagatgcg ctcgaaaagt atgatctact
    10381 tttcgggggc caatcctagt atgtaagcta caaactataa atgtaatgca aaacgctcct
    10441 tccagaactg agacatcacc ccacctctac gcaacctcca aaatttggaa tggatgtcag
    10501 cttcgttaaa gtacgccgat cggcaggaga tggttgatgc gcggaacatc ccttgcgggc
    10561 cgcataaccg taatcgtgcc caagccggag acgggccggg cccgggcatc ccccacgggg
    10621 aaaaacgtac cgccaatacc gccttactga acgcgaatta tagaaccttt ctagaacggt
    10681 acacaagctg tacgcaagcc gtttgtttcg tgaaaaatag cattcttatt ttcttataaa
    10741 tttctaaacc tattgcttat tttcttatgc cattaaacag agataattat aatgcattca
    10801 gtgattctgc tggcaaaata tcatgtaatc tatgcggtgt ggggacacgg agcaaataca
    10861 tatgtccgct gcctgcaggt atgtgcaaac gagttcagaa aatggcatag aactagataa
    10921 tgagaccccc actttcagtt cagtgagata agagaagatc atcaaagcgg gaaaacaagg
    10981 ctcgggagat ggatcaatgg cgcgggaggg gtctaggcgc cacgaggtct catgcatcaa
    11041 aatgcccaaa gattccggga tttagaccat tctatagtcc gctctgtact agcattacat
    11101 gatggttatt ttcgtctcac cttctgtatt gagattccaa ctccggaggg tagtatgtat
    11161 gtatgagcat gacttcccaa atcatgtagt aaggctagat ttgaaggcca gcacaccact
    11221 atatagctct agcaagggtt tgtggtcagc agagttgtct acttagaaca tgggagataa
    11281 agtaagtttc taggttattg ctaaatagtt tgaacaacac agccgaagca tctcacgacc
    11341 taaatttcgg acaatctatc agtttgtaat gtaacaaaat tctgattttt aatatcttca
    11401 acctcagagg tttgcagccc atgaaaattg tgtgcttcgt tgtattaatt cagtaattta
    11461 ctttcggctg cctgcagagg ctctagctgg cccccctccg taaataagag atggatagtt
    11521 ttgtagcgga ctagccctct cgttttttgc cttatatcaa tcagacttat atcttctccc
    11581 gaaccaagtt tcttatagat ctgtaaatat acgatatcct gtacgtgaag ggcgtaccag
    11641 gaacttatta cattcttacc tctatcgttt cttcatcgag tttcatatca tgtcattgaa
    11701 tacagagcat tcaaaaggag accttcgtct tctcttcgga ccacaatgct ctgaaattga
    11761 agactccatc gcccacatcc gggatgccgt atacaaagat tcagccggtc tggggttctt
    11821 atctgatatt cttgacgagc ttccctcctt atggcccgtc ataacttctg cctggccagc
    11881 cctacggaag gtgcaggggg agaagcaact agctgcactg gggcggcgtt ttgagaatgg
    11941 atctccagat agtgaagcag aaccctcaag tctcatcatg actccagtca cggtgatgaa
    12001 acatctagtt gacttttgga atctccaaaa cgttgcgaca catccggcgt ttccatcctc
    12061 gccattatca cggaccacag ccccaaggat aatcgactca caggggttct gtgtgggtat
    12121 tctggcggca attgctgtgg cctgctccca ggatacacgg gaattccagt ctttggcttc
    12181 gaacgccata cggctcgctg tctgtattgg ggcgttggtg gacttcgatg agatcgtgtc
    12241 gggtaaggct aagtcaattg cagtgcggtg ggagacccca gcggaccatg actatcttga
    12301 acagaccttg acaaaaagtc ccaatgttag tttctcctca tggaaagaaa aggaaacaaa
    12361 agcaaagagc tgatagacat tcaaggttta tatctcctgc tatacagacg ttaacagcgt
    12421 cactatcact atccccggtg acactgcaca acgggtcaaa ttcaaacagg agcttagcgg
    12481 ccgtggtctt cacacaaagc cgatccccct ccaaggccgc ttccaccacc agcaaacaca
    12541 ccgcgaaggc atccagcaca taatgaatct atgtgtgaag gatcctcgct ttcaactccc
    12601 tcacagcaac gcgttgatat taccccttcg atcaagtcac aatgggcagg tgctcataaa
    12661 tgcagccatg ttgcacactg ttgccttgga atcaatcctc tctgtcaagg cagactggtg
    12721 gggaacagtc tccgcattac taaacagcgc cgatatggaa gttgacgagt cccgtcttct
    12781 atccatcggc caggaagagt tcgtcccacg atcagctaga ggccgtctgg tagccaggag
    12841 caaccttgat gtctacgggg caggagtgtt tgctaacggt aacacgtcgg ctcgctccgc
    12901 agtgtcgctg cagaacggca cgaacaccct caatggtagt ccacaggcag ctgagatgcc
    12961 acctattgcc attactggca tggcttgtag atattctaac gcagacacca cgagcgagct
    13021 atgggatttg ctggagctgg gggtatgtac agtggagaag gcccctggga atcggttccg
    13081 gatgccagac ttgcagcggg agcccaaggg cccattttgg ggtcacttcc tcgaccggcc
    13141 agatgcattc gaccatcgtt tttttaacat ctcagcgcga gaggccgagt ccatggatcc
    13201 acaacaacgc gtgttgctgc aagtagcata tgaagccatg gagtctgccg gatactgcgg
    13261 atggcagcac actgagctat cggacgaaat tggctgctat gtgggagtgg gatctgagga
    13321 ctatactgag aatgtggcat cgcggaatgc gaatgccttc tcagccacag gaaccctgca
    13381 gtcatttata gctggccgta tcagccatca tttcggctgg tcgggcccat cgattacgct
    13441 agatacagcg tgttcatccg cagcagtggc tatccatatg gcatgcaagg tacgatatga
    13501 gactcccatt gacctatctg aaagtgcaat ggctgactga tgtataaatg ataggccctg
    13561 caaacaaagg agtgctcgat tgccgtggct ggcggtgtga atattctgac aaaccccagg
    13621 gtgtaccaga acctggctgc tgcttctttc ctgtcatcta cgggagcatg taagtcgttt
    13681 gatgtctctg cggatggata ctgccgcgga gagggcgctg gactcgttgt ccttcggcca
    13741 ttgcaggatg cgattgacaa cggcgaccct atcctcggcg tgatcgctgg ctcagtcgtc
    13801 aaccagggct cgaacaggtc acccatcacc gtccccgatg cagagtctca acgatcgctg
    13861 tatagaaaag ctttgtcact cgctggggtt gccccggatg aggtcaccta tgtggaggcc
    13921 catggcactg gtatgtatcc tgctttcttt ttacccttgg tctcctctat tctgccctct
    13981 tctatttcgc ctgcagttta gtaacaatgt caaaggcaca caagttggag atccgattga
    14041 actggaaagc cttcgcaagg catttggaaa cccgctccga agtcagagtc tccatgttgg
    14101 gtccatcaag ggtaacatcg gacacactga gacctcctcg ggggtcgccg ggctgttgaa
    14161 gacgatcctc atgcttcaga agcaacgaat accgaaacag gcaaacttca ggcagttgaa
    14221 tcccaaggtc atgcctccac tcgagaacga ccgattggtg attcccgtag agtcaaccaa
    14281 atgggcatca gcgagacggg ttgctatggt cagcaattac ggggcatcgg ggagcaacgc
    14341 cgcgcttata gtgagagacc acactcctag cctatcggga caggggaagg caatggcgga
    14401 atacattcga gatatgccta tcttgatttc tgcacggtct gaagaatcta ttcgggccta
    14461 ttgcggtgcc cttcgcacca cccttttgag gcatccgtat tccaataccg tcgtccggga
    14521 attggcgtac aacgtcgcaa tgaagcagaa tcgaacactg ccgtttactc ttaccttttc
    14581 aacctcttct gatccgacat cactgagcac ccgcttggag gctatcgccg caggcaagtc
    14641 tgccgatatt atccagaagc gggaatccaa cgagccccca atagttttgt gtttcggcgg
    14701 tcagaatgga gttacttcga gcatttcaca agaactttac gacagctgtg tccttttaca
    14761 gacgcacctc atggcgtgcg agcaagcagg ccagaagctc ggccttccca gtcttttccc
    14821 aactatcttc acatcagacc ccatcgtgaa taccgtttac ctgcacttca tgctcttctc
    14881 tatacagtac gcatctgcca gagcctggat cgactcagga ctgcgcgtag accgcatagt
    14941 gggccatagc tttggtcagc tcactgcgct atccgtggct ggcagtttga gtgttcaaga
    15001 aggcatccgc ctggttactg agcgtgcacg cctgatccag tccaactggg gcccggagtc
    15061 aggggtgatg ctcgctgtgg agggtacgca ggccgaggtc cagcgtgtgc tagagcagac
    15121 aggccaccgt gctgaaattg cctgctataa tggaccacag cagcaagtgc ttgccggcac
    15181 gggggaatgc atccgagcgg ttgaagacgc tctcgctaca aacccattga caagcaacgt
    15241 cagggtcaga cgtttggaga actcgcatgc cttccactct agacttgttg atagcattgt
    15301 gcccggcctc acagagctcg cagagtcctt tgtctaccaa gcaccagcta tccccatcga
    15361 agcctgttcg gcgactggcg actggtcgat tgtcaccccg gcaaagatcg tcgagcacag
    15421 tcgcatgccc gtgcacttcc aacgcgctgt cgaaagaata gctcaaaaac tacaagttcc
    15481 cgctgtctgg ctcgaagccg gctcagcctc gcctatcatc cccatggtgc gtcgagtgct
    15541 ggagaaatcg tccgcaactc acacatacca tagggttaac ctcgatgggt cggacggaag
    15601 cgggaatttg gcaactgtca ccagcgccct ctggggtcag ggcgtccatg tccagttctg
    15661 gcccttccat cactcgcagc gtgggacctt cggctggatg aaccttccgc cgtatcagtt
    15721 cgcgaagaac agacactggg ttgactttga ccctactgct ttctcgtttt ccggatcctc
    15781 cgccgaaccg caatgtggca gtcaggagcg ggctggcctg ttgcgcaagt tgagcgacgg
    15841 cccagaggag tatctatttg ccgttaacac ccaagatgta ttgtataggt catgcacgaa
    15901 ggggcacgcg gtattggacc aaacattgtg tcccgcatcc atgtatatgg agatggtcct
    15961 gcgggcagca acttccgtat tcaccttggg tgaatcctca acgctgacta tgtctcatat
    16021 cgaggacctg gtgatatcat cccccttagt attagatccg caaggaagcg tgttcgtacg
    16081 actgatccca gaggcagtgg cttcttccca gacgtggtca ttctcgatat ttagcagtag
    16141 cgggacgggt aatgagtcgt cgattcatgc tacaggcagt gtatccttat gcaatgaaag
    16201 gtccagggct ctgtcacact ttcagtctat gaatcggttg atggacccgg cacgggcaag
    16261 aggaattgag gatcatctgg catcaaacgg actgaaagga tcgacggttt actctgccct
    16321 cgaacaggtt accaattatg cagactactt ccgcggagtg aggcaggtgt ttgcaaatgg
    16381 ccgtgaggct gcggggctgg tcagtatggc accgtcagcc accgagacca cgtgcaaccc
    16441 catcctcctg gacaactttc tgcaagttgc gggaattcac gtcaactgcc tctctggccg
    16501 cgaagcagag gaagtattcg tgtgcaatgc tatcggggaa acgtatgtta gcgattcgtt
    16561 gttcaaaaag gaagacggag ctattccgtt atcatggaag gtatatacca actacgtccg
    16621 gccgtccaag aatgagatcg tgtgcgatat ctacgtgatg aactctcaag gagacggtct
    16681 taccgccgca attatgggcg ttcggttcat gagtgtctcc atccgctctc tcactcgcgc
    16741 actggccaag ctgaacaaca atttccctga cgtcccacaa ctcccgccca cgatccagcc
    16801 agcaattgtg acagccgatt atgatgaagc cagtgacaat gtaaatgtgg atagcgacct
    16861 tgttgcagtc caagagatgc tttgcgagct gtttggagtt agtgtcgaag aggtatctcc
    16921 atcagtctcg ctgatagata tcggagtgga ctcgctcata agcacagaag tgctctccga
    16981 gatcaagagg agattccata aggatatttc ctattccacc ttggtggata ttcccaacat
    17041 ccagggtttg acagagcata tcttcccggg acattctcac ctagctcctt cccagattgt
    17101 gatcaaacca gtacggcagc agacagtgat accgcaaact gtaacttntc tgcctgtgcc
    17161 agctaacgcc ggaccgtcgc tagtctcagt agcacaccaa tgcttctatg agactcacgc
    17221 cgcggtatcc cacacacaca atgccgactg ggccggcttc ttcaatgcca tctatccgca
    17281 acaaatgaca ctcatcacgg cgtacatcct ggaagcattc cgcgccttgg gctccccgct
    17341 agagtccagt caggcagatg aggtccttcc tattatttcc gtcctacctc gccacgagca
    17401 gttgaagaag cacctgtata caattttgga atccgtcaac ctcgtgcgcc aaactccaac
    17461 tggtcaactc gtgcgcacag cgacacccat ctcgccgctc tcatcacacg ccttgcatgc
    17521 ccagatccgg gatgaacacc ctccatatgc actggagcac gatcttctac agatcacagg
    17581 ctcgcggttg gctgagtgtc tgaccgggca agcggacggg gtatcgctaa ttttccagga
    17641 ttcccagact cggcgcctgg taggagatgt ctatacggac tccccggtgt tcaagtcggg
    17701 taacctctac ctcgcacagt atctcacgga tgtcattcaa actctcggaa acggtcggca
    17761 ggttaaaatc ctcgagatcg gggccggcac aggaggcact accaagaatc tcctcgagca
    17821 gctctcggcc ctccccggaa tggcgacacg catggagtat acattcacgg atatctcgcc
    17881 atcgcttgtt gcagccgcgc ggaagaagtt ttccaagtat gatttcgtac ggtacgaaac
    17941 tattaacgtg gagagtagcc ctccctcgct cttgcacggc caatacgaca ttgtgttgtc
    18001 gaccaactgc gtccatgcta cccgaaatct cgtcgagtcc tgctcaaata tccgcaagct
    18061 cctccggcct gatgggatct tgtgtctcgt tgagctgacg cgtgacatat tctggttgga
    18121 tcttgtgttc ggactcctgg agggctggtg gcggtttgag gacggtcgga agcacgcgct
    18181 ggccactgaa gatctttggg atcagacgct tcgccaatct ggcttcgagt gggtgggctg
    18241 gacgaataat gaggctgtag agtcaaatgc tctgcgcgtt attgtcgcat cgccgacgaa
    18301 ggccccttct gctctggaga tttgctccaa gccggcaaac atggaaactg ttgtttgggg
    18361 cgaaagaaat ggtctgcagc tgctggctga tatattttat cccgacgtgg ttgacaccac
    18421 gcagaaacga cgagcatgtg gtaagttcaa attcatcttt tgtcccttgt aataactcca
    18481 tttcatactt tcatttgcta accctcttca gctctgatgg ttcatggagg tggccacgtc
    18541 atgctatctc gtaaagacat ccgtcctgcc cagacacaga cccttctcga tgccggattc
    18601 ctgcccatca gtgttgacta ccgcctgtgc cctgaggtta gcctttcaga aggccctatg
    18661 gccgacgtgc gcgacgccct aggttgggtg cgccgcatcc tcccaaatat ccccttgcta
    18721 cgtccagata tccgaccgga cggcaaccag gttgtggcta tcgggtggtc cactggtggt
    18781 catctcgcaa tgacgctggc ttttactgct cccgctgtgg gtatcgccgc tccagaggcc
    18841 atattggctt tctactgtcc aaccgattat gaagatccat tttggtcgag gccaaacttc
    18901 ccctttggac agactgtcgc gtcaaatgat atagagtacg atgtctggga aggcgtgcag
    18961 agcgccccga tcaaaggcta taatccagcg ttcaaggaac ggccactagg gggctggatg
    19021 tcaaccagcg acccgcgtag tcggattgca ttgcacatga attggacggg acaaaccctc
    19081 cctgtgctgt tgggaggcat gcacaaagag tttcgcatac ctgatgaact acctcgtccg
    19141 acagacgaag agattcaggc agttagtcca aactatcaga tccgcatcgg gcggtaccga
    19201 acacctacgt ttatggttca tggaacaagc gatgaccttg tcccgtgcgc gcagaccgag
    19261 tcaacatata acgcgttgac ccaaaacggc attgaggcag atatcagggt ggtgcaggga
    19321 gcggtgcatc tatttgatct ttatccgagc tctcatgctg gccagaatgc gaaggaagca
    19381 gtggctgatg ggtatgaatt tttgaaaaga cacattcact ctaagggtta tagcgacaag
    19441 gattagattt agattcaaat tttgcttccg cattgaatat tacaatttga agattatatt
    19501 gaggtcttgc tatatctaca acatccagaa cgggcgagaa aatggatatg ttcgggttca
    19561 ctaacgctgg agatttgaca agttggaaca cgacggtgtg ccaataagcg gccctggccg
    19621 caacaaggag gaagaaaacg aagttactct gtctttcagt ttacaatcta agagtttagt
    19681 aggctgtaca gatctgcttt tcttccaagt atcccatgcg gtctgaactt cactaaatca
    19741 taagacttgc tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19861 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    20041 nnnnnnnnnc cgcgaagatc aaaggtcgtg ggggtgttag gtagcggaga atgaatgtgc
    20101 gggttattag gagggcagag aagacttttg tccagaatgg cgttggtggt tcgtatctag
    20161 ttgatgttag cgctcgatat ttcgttttat aagatcagat cttactattc cacatacaac
    20221 atagccttcc tcagccggtc atccatcatg aacgaagtga actgcaatcc caccggatgg
    20281 aataccttcg gcaaattata aagcagcaca gctgttgcct gatccgctga ttcccgattc
    20341 tgagcatctg gaaccatata cttgacctca tactcctgac tccaagtatc cacctcctcg
    20401 agccaatgta ttccatccct aaaccccgtc ttacctgacg ggagaatgtc agaactaata
    20461 cctagcgcgt cacctagact cttccaaaac gttccaatag cacagcgttc caaatcactt
    20521 agcggccgcc actcgaatgc cgcgatgaaa tttacaggct ggacggcaaa gagcgcaagt
    20581 gtgtagagca aatctgtatc aaggatcttg cctgaagctt ggtagccgct gtgtaggaaa
    20641 cgcgtgcggg ctacagagag aaaagcccgt tgcgaggtag ggctattttc taccatttcg
    20701 ccgataaggg cggctgtgtc tgtatagcgc ttgaaggagg tttctggttt agaaaattgc
    20761 cctgtcttta tgagaaggtg ggagattgtt ggaatgccgt aagtctagag gaggttagaa
    20821 taagaaaaat atagattggt gtatatattt gcgtacccga aataaagcaa actgccctgc
    20881 tttcacaaac atgaatggga attctagctg cgccgtttct ttttgaatct ggaatgcttc
    20941 ttcgtctgtc atcttagcca tagactcgcg tgtcgggaag tagaactttt tttgtagctg
    21001 tttaagtcgt ctatagcgca gcgaattgat aagaaggggg tacgcaatca acaagcccac
    21061 tgcaaatgaa aaccattgcg gcatggtatt gaaaatagct ctggtggttg cagagaacga
    21121 gggagttgta aagaaagatg tgcctttatc catnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21661 nnnnnnnnnn nnnnnnntat tattatttat tcagatatac tccgtactat acagtgcttc
    21721 tccaaaagta catacatgta cggtaaatac tgcccgcata ttacctagta ctttggtgta
    21781 gatgcattgg tgtagatgca ttatggtata ggaagcagct cggtcacgat aggctccacg
    21841 gtagctctcg ctgcggtaag acggagcatt cctcgtcact catgcacccg ntccaccgtc
    21901 tatgttattc tcatgcatgg tcattagaaa ttcatttttc tgatagtcac cataacgtgg
    21961 atacggcaac gtgggggcag aaaactgcag gatgatgcgg caatgtggaa aaaccgggtc
    22021 tcttntagta caggatgtct cccctagaag tgctttgtgc tgcgataccg ggtataactt
    22081 ttgatagttc tcaaggacag cccgattttc tagctcatct gcaaagtttt tgagtttccg
    22141 tctttnaagg atatttgcca atctctaaca ctttattgca ttncattcac naacatggtt
    22201 ggttcaatgg agaaccctgg ttcatggggc cttgcctgtc ttctgatcag cacctcgcgg
    22261 ttcaaccgat atatgcccta ctacacgatg atggccgctg gtaaggagag caccattcca
    22321 agctctctca tgaataaagt attaacttga aatctccgtg acaaaacagt atggtctacc
    22381 ttgattgctg gcgctttaaa gttgcaagag gatcccgcca gtctctctgt cgagtacatc
    22441 ctcttcaaag ccggcctgtg ctttgttcac tgcttgttac tatgcggtgc tgggaacaca
    22501 tggaacgacc tgatagaccg tgatattgac gccagggtgg aaaggacaaa aatgcggccg
    22561 ttggcatctg gaaaagtctc aaccgtcgag gccctggtat ggatggtcgg tcagtatttt
    22621 ctgtcggtga aaatgctgga cttaatattg gataacagaa gcatgtaagt ctgacattca
    22681 gtgtgataaa actccggccg catggaagag cacaacttga ttaaccccgt ccatccctct
    22741 tagatggggc ttaatgctgc ctttgacagc cagtatcatg ctgtatccct acttgaaacg
    22801 acccgtattc agcagagtct tcatctaccc ccagtatatc cttggcttgg ccgtcgccta
    22861 tccatcgata acaggctggg cctcaatcaa cgggcaagag cagtccatgt ctgagatctt
    22921 cacacattgc accccgatct gccttcttat cttcttctgg tgcctctatt tcaacaccgc
    22981 ctacagtcac caggacagcg tcgacgaccg gaagatgaat atcaattctg cctatgtggt
    23041 cgcggggcaa cgcatccggt tattcctcgc cttcctgggt gctctaccac tcgcggtgat
    23101 tccgtatgtt gtgttgaaaa tcaactctcc ctggctgtgg ttctcttgga tggcggtttg
    23161 gaccgtttct attgtgatgc agattgttcg gttcgattcg aagaagcttg aaagtggcgg
    23221 gcgtattcat tgggacaact ttctgttggg actgtggact accgttgctt gtatagtcga
    23281 ggtcggtctg cagaaagtag agttctggaa cctaatctag
//
