LOCUS       BGC0002617             17174 bp    DNA     linear   PLN 21-MAR-2016
DEFINITION  Penicillium sp. YT-2016 psychrophilin biosynthetic gene cluster,
            partial sequence.
ACCESSION   BGC0002617
VERSION     BGC0002617
KEYWORDS    .
SOURCE      Penicillium sp. YT-2016
  ORGANISM  Penicillium sp. YT-2016
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Penicillium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 18:05:59
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17174
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..17174
                     /db_xref="taxon:1813945"
                     /isolate="IBT 24420"
                     /mol_type="genomic DNA"
                     /organism="Penicillium sp. YT-2016"
     misc_feature    <1..>17174
                     /note="psychrophilin biosynthetic gene cluster"
     protocluster    1..17174
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[657:14847]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      658..>14847
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..17174
                     /SMILES="NC([*])C(=O)NC([*])C(=O)NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..17174
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002617"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..17174
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     mRNA            <658..>7197
                     /product="PsyA"
     CDS             658..7197
                     /NRPS_PKS="Domain: AMP-binding (40-442). E-value: 5.5e-76.
                     Score: 247.6. Matches aSDomain:
                     nrpspksdomains_AMQ36132.1_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (583-652). E-value: 3e-14. Score:
                     44.9. Matches aSDomain: nrpspksdomains_AMQ36132.1_PCP.1"
                     /NRPS_PKS="Domain: Condensation_DCL (692-957). E-value:
                     7.9e-41. Score: 131.9. Matches aSDomain:
                     nrpspksdomains_AMQ36132.1_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1117-1516). E-value:
                     3.4e-79. Score: 258.1. Matches aSDomain:
                     nrpspksdomains_AMQ36132.1_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (1650-1715). E-value: 5.5e-16.
                     Score: 50.4. Matches aSDomain:
                     nrpspksdomains_AMQ36132.1_PCP.2"
                     /NRPS_PKS="Domain: Condensation_DCL (1780-2041). E-value:
                     3e-32. Score: 103.8. Matches aSDomain:
                     nrpspksdomains_AMQ36132.1_Condensation_DCL.2"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     252.1; E-value: 1.5e-76)"
                     /gene_kind="biosynthetic"
                     /note="two module nonribosomal peptide synthetase; NRPS"
                     /product="PsyA"
                     /protein_id="AMQ36132.1"
                     /sec_met_domain="Condensation (E-value: 2e-38, bitscore:
                     119.8, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 6e-95, bitscore:
                     305.8, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.8e-16, bitscore:
                     47.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGTIVLEPRTLSSEDLCRLKQWNALIPESQAGCVHQLINTHCEE
                     QPDAEAVSAWDGSFTYGELARVTDHVSAYLVEHGVGPEVVVPILLEKSRWVPLAMVSVM
                     KAGGAFMLLDSGHPPSRLTELCARVGAEIMITSRGLAASSECLGVKAVAILDEESSAVH
                     HPLSHGKTAAVDVKPRNLLYVVFTSGSTGQPKGVLIEHGSYVAGAQLHIPALHMGRSSR
                     IFQFASNAFDAIITDTLSTLIAGGCVCIPSEGQRIDQCIETLDFFRATHVFLTPSFART
                     LSHQRPSKFLQVLVLIGEVVQDSDVTQWAHKVTIMNGYGPAECSAAATVQSHLSSASSP
                     RNIGHRVCGGLWLVNPDDVDQLAAIGEVGELLIEGPTVGRGYLDDPGRTNAVFIRGPAW
                     LKQVRGHDNHENSRLYLTGDLMCYEADGSLCYIGRKDSQVKLRGQRIELPEVEDHVRQA
                     LPKKVEVVVEMVPIAGINQSLVAFIQCDLGASTANGNGDSAANGDIVTYSTGEFKKQVL
                     AVKTRLAATLPSFMVPGFFIPVQRFPLTRAGKVDRKNLRGLLAHDTHSLDHFRILDEDR
                     RPPSTEREQALQRVWSEALNIAPDMIGAEDNFFHFGGDSITAIFVVAGLRAAGYELTVA
                     EILGSPRLSHVASLMRDTASMETQAHMPPFSLLGTHDARDPALEAAARQCQVDVDLVED
                     IYPCTSLQEGLFALGASQQGAYVGRWTYAFNEATVDPSRLRRAWNEVAQSNAILRTRII
                     KTPSHRMYQVVLRNPVAWEDPSRCTLEVEFGRPLVMFALKKDPRTQSFQLTVTMHHALY
                     DAWSLQLLLDQVEAIYLGQSHQSPPPFNRFVKYISKGMSDTKQERFWRAEFAGLAADPF
                     PSFQHTHQRPTPSVTHRRTINPAQFSPRMFTRSTVARLAWALVQSQYQNRTDVVFGATV
                     SGRTAPVSGVESMTGPTIATIPWRVQLHPERTVAQSLEEIQSQTARCMPYEQVGMHHMK
                     NWGEEAKAACSFQTLLLVQQNERGAGLPLLGVDEDSGNWRAFATYALTVFCDLNSAPFG
                     LEAWFDPDIIPAAQVERLLNQFAHIIEGICHGMNASIADLLASVCSSHVQQMLEWNQMP
                     DIPQVCVHDLFAQRCQEHPVALAVDAWDGTFTYAELDKLSTSLARYLSSRGVCAGWFVP
                     ICSEKSRWVVMCMLAIIKTGAAFVLLDPSHPKKRLDSACKLTQTPLVICSRDALALALD
                     LTGEVIVSSGDYSGWGEDLPTQDCVALPNVDPGQPLFVAFTSGSTGIPKGVLVTHNSYL
                     ASTLPIVEQVKISPGVRWLQFASFAFDMSAVEILWTIICGGCLCILSESQRLDEFASAA
                     ASFQPTHAFLVPSFARTLNPETLPSLRALLLAGEPPNAGDIQLWCERVSLMNLYGPAET
                     GITHGLYHYTQSTAPTNVGRNTGSATWLVHPDDPERPVPIGAVGEALIEGPNVGPGYLR
                     DPERTAVSFIQVPKWLQGLRGRSDGIVYLTGDLFRCDEDGCYIYLGRKDNQVKLRGQRI
                     ELGDVETHVQTAFDAGSLVIVELVTQAAGITQPCLVAFIFNPSLQDRMDDLFSAPNTQF
                     SAQVVVVKDRLQKALPRFMIPSYFIPLSYIPRTTSGKVDRRQLRLALSTLPEQQITEYL
                     ATTAKREPSTEIEKRLQHLWAKGLRLAPEDIGVDDNFFDVGGDSIKAMYLAATARDEGL
                     ALTVTDILQTPTLSALAQQCTPLQSLSTPEVVPFSLVDEPTKSFVTQRVQDLGIISGEA
                     HIVDIYPATEGQRWLIDQWSPVHFCYFISATIDPMRLRAGCAVVMARHSILRTAFVRTK
                     NETSGITQVVLDAPEVPFQQLHTDEDLALYCDELWQAKGTLSSTIDTLPVKFQLLSRSH
                     AEHALVIQLSHAQYDGVSLPILTSDLAAAYSVGAKSFSTTGTDFAPYVYFRSSRKSDVA
                     CNFWREYLRASSMFRLLPRRELSSVQRGPDDWPNRRVSIVRGISMPTAPSGITTASLIK
                     AAAALVLAKRETKSDLVLGQTVNGRSMPLPGIERLLGACLNFIPFRVTFEPGWSAMDLL
                     HHTHAQCTQTLEYDYMGLSEILQQSSEMPPGTQFGCVVQHQNIAQTGEQGPELVLDGVT
                     CQSSALANFNPMSGLWILSTPRGESLEVMTCTVEELLSPAEARGLNDELCETIMDLAQN
                     PDASLDLNIW"
     aSDomain        778..1983
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMQ36132.1_AMP-binding.1"
                     /evalue="5.50E-76"
                     /label="AMQ36132.1_AMP-binding.1"
                     /locus_tag="AMQ36132.1"
                     /protein_end="442"
                     /protein_start="40"
                     /score="247.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="THCEEQPDAEAVSAWDGSFTYGELARVTDHVSAYLVEHGVGPEVV
                     VPILLEKSRWVPLAMVSVMKAGGAFMLLDSGHPPSRLTELCARVGAEIMITSRGLAASS
                     ECLGVKAVAILDEESSAVHHPLSHGKTAAVDVKPRNLLYVVFTSGSTGQPKGVLIEHGS
                     YVAGAQLHIPALHMGRSSRIFQFASNAFDAIITDTLSTLIAGGCVCIPSEGQRIDQCIE
                     TLDFFRATHVFLTPSFARTLSHQRPSKFLQVLVLIGEVVQDSDVTQWAHKVTIMNGYGP
                     AECSAAATVQSHLSSASSPRNIGHRVCGGLWLVNPDDVDQLAAIGEVGELLIEGPTVGR
                     GYLDDPGRTNAVFIRGPAWLKQVRGHDNHENSRLYLTGDLMCYEADGSLCYIGRKDSQV
                     KLR"
     aSModule        778..2613
                     /complete
                     /domains="nrpspksdomains_AMQ36132.1_AMP-binding.1"
                     /domains="nrpspksdomains_AMQ36132.1_PCP.1"
                     /locus_tags="AMQ36132.1"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       961..999
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0001"
                     /evalue="6.10E-02"
                     /label="NRPS-A_a2"
                     /locus_tag="AMQ36132.1"
                     /protein_end="114"
                     /protein_start="101"
                     /score="7.3"
                     /tool="antismash"
                     /translation="SVMKAGGAFMLLD"
     CDS_motif       1204..1260
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0002"
                     /evalue="2.50E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="AMQ36132.1"
                     /protein_end="201"
                     /protein_start="182"
                     /score="29.2"
                     /tool="antismash"
                     /translation="YVVFTSGSTGQPKGVLIEH"
     CDS_motif       1750..1836
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0003"
                     /evalue="1.80E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="AMQ36132.1"
                     /protein_end="393"
                     /protein_start="364"
                     /score="39.4"
                     /tool="antismash"
                     /translation="IGEVGELLIEGPTVGRGYLDDPGRTNAVF"
     CDS_motif       1948..2013
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0004"
                     /evalue="1.80E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="AMQ36132.1"
                     /protein_end="452"
                     /protein_start="430"
                     /score="32.9"
                     /tool="antismash"
                     /translation="YIGRKDSQVKLRGQRIELPEVE"
     aSDomain        2407..2613
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMQ36132.1_PCP.1"
                     /evalue="3.00E-14"
                     /label="AMQ36132.1_PCP.1"
                     /locus_tag="AMQ36132.1"
                     /protein_end="652"
                     /protein_start="583"
                     /score="44.9"
                     /tool="antismash"
                     /translation="EQALQRVWSEALNIAPDMIGAEDNFFHFGGDSITAIFVVAGLRAA
                     GYELTVAEILGSPRLSHVASLMRD"
     CDS_motif       2476..2505
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0005"
                     /evalue="3.40E-01"
                     /label="PCP_mE"
                     /locus_tag="AMQ36132.1"
                     /protein_end="616"
                     /protein_start="606"
                     /score="4.6"
                     /tool="antismash"
                     /translation="NFFHFGGDSI"
     aSDomain        2734..3528
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMQ36132.1_Condensation_DCL.1"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="7.90E-41"
                     /label="AMQ36132.1_Condensation_DCL.1"
                     /locus_tag="AMQ36132.1"
                     /protein_end="957"
                     /protein_start="692"
                     /score="131.9"
                     /tool="antismash"
                     /translation="EDIYPCTSLQEGLFALGASQQGAYVGRWTYAFNEATVDPSRLRRA
                     WNEVAQSNAILRTRIIKTPSHRMYQVVLRNPVAWEDPSRCTLEVEFGRPLVMFALKKDP
                     RTQSFQLTVTMHHALYDAWSLQLLLDQVEAIYLGQSHQSPPPFNRFVKYISKGMSDTKQ
                     ERFWRAEFAGLAADPFPSFQHTHQRPTPSVTHRRTINPAQFSPRMFTRSTVARLAWALV
                     QSQYQNRTDVVFGATVSGRTAPVSGVESMTGPTIATIPWRVQL"
     aSModule        2734..5802
                     /complete
                     /domains="nrpspksdomains_AMQ36132.1_Condensation_DCL.1"
                     /domains="nrpspksdomains_AMQ36132.1_AMP-binding.2"
                     /domains="nrpspksdomains_AMQ36132.1_PCP.2"
                     /locus_tags="AMQ36132.1"
                     /monomer_pairings="X -> X"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       2836..2913
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0006"
                     /evalue="1.30E-07"
                     /label="C2_DCL_024-062"
                     /locus_tag="AMQ36132.1"
                     /protein_end="752"
                     /protein_start="726"
                     /score="23.9"
                     /tool="antismash"
                     /translation="ATVDPSRLRRAWNEVAQSNAILRTRI"
     CDS_motif       3076..3141
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0007"
                     /evalue="4.50E-06"
                     /label="C3_DCL_135-156"
                     /locus_tag="AMQ36132.1"
                     /protein_end="828"
                     /protein_start="806"
                     /score="19.3"
                     /tool="antismash"
                     /translation="MHHALYDAWSLQLLLDQVEAIY"
     CDS_motif       3424..3519
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0008"
                     /evalue="6.90E-15"
                     /label="C5_DCL_263-294"
                     /locus_tag="AMQ36132.1"
                     /protein_end="954"
                     /protein_start="922"
                     /score="47.4"
                     /tool="antismash"
                     /translation="DVVFGATVSGRTAPVSGVESMTGPTIATIPWR"
     aSDomain        4009..5205
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMQ36132.1_AMP-binding.2"
                     /evalue="3.40E-79"
                     /label="AMQ36132.1_AMP-binding.2"
                     /locus_tag="AMQ36132.1"
                     /protein_end="1516"
                     /protein_start="1117"
                     /score="258.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FAQRCQEHPVALAVDAWDGTFTYAELDKLSTSLARYLSSRGVCAG
                     WFVPICSEKSRWVVMCMLAIIKTGAAFVLLDPSHPKKRLDSACKLTQTPLVICSRDALA
                     LALDLTGEVIVSSGDYSGWGEDLPTQDCVALPNVDPGQPLFVAFTSGSTGIPKGVLVTH
                     NSYLASTLPIVEQVKISPGVRWLQFASFAFDMSAVEILWTIICGGCLCILSESQRLDEF
                     ASAAASFQPTHAFLVPSFARTLNPETLPSLRALLLAGEPPNAGDIQLWCERVSLMNLYG
                     PAETGITHGLYHYTQSTAPTNVGRNTGSATWLVHPDDPERPVPIGAVGEALIEGPNVGP
                     GYLRDPERTAVSFIQVPKWLQGLRGRSDGIVYLTGDLFRCDEDGCYIYLGRKDNQVKLR
                     "
     CDS_motif       4195..4236
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0009"
                     /evalue="4.20E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="AMQ36132.1"
                     /protein_end="1193"
                     /protein_start="1179"
                     /score="10.8"
                     /tool="antismash"
                     /translation="LAIIKTGAAFVLLD"
     CDS_motif       4441..4497
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0010"
                     /evalue="2.80E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="AMQ36132.1"
                     /protein_end="1280"
                     /protein_start="1261"
                     /score="22.9"
                     /tool="antismash"
                     /translation="FVAFTSGSTGIPKGVLVTH"
     CDS_motif       4978..5067
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0011"
                     /evalue="3.60E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="AMQ36132.1"
                     /protein_end="1470"
                     /protein_start="1440"
                     /score="35.3"
                     /tool="antismash"
                     /translation="PIGAVGEALIEGPNVGPGYLRDPERTAVSF"
     CDS_motif       5170..5235
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0012"
                     /evalue="1.30E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="AMQ36132.1"
                     /protein_end="1526"
                     /protein_start="1504"
                     /score="36.4"
                     /tool="antismash"
                     /translation="YLGRKDNQVKLRGQRIELGDVE"
     aSDomain        5608..5802
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMQ36132.1_PCP.2"
                     /evalue="5.50E-16"
                     /label="AMQ36132.1_PCP.2"
                     /locus_tag="AMQ36132.1"
                     /protein_end="1715"
                     /protein_start="1650"
                     /score="50.4"
                     /tool="antismash"
                     /translation="EKRLQHLWAKGLRLAPEDIGVDDNFFDVGGDSIKAMYLAATARDE
                     GLALTVTDILQTPTLSALAQ"
     CDS_motif       5677..5706
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0013"
                     /evalue="2.80E-01"
                     /label="PCP_mE"
                     /locus_tag="AMQ36132.1"
                     /protein_end="1683"
                     /protein_start="1673"
                     /score="4.8"
                     /tool="antismash"
                     /translation="NFFDVGGDSI"
     CDS_motif       5995..6093
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0014"
                     /evalue="5.10E-07"
                     /label="C2_DCL_024-062"
                     /locus_tag="AMQ36132.1"
                     /protein_end="1812"
                     /protein_start="1779"
                     /score="22.0"
                     /tool="antismash"
                     /translation="FCYFISATIDPMRLRAGCAVVMARHSILRTAFV"
     aSDomain        5998..6780
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMQ36132.1_Condensation_DCL.2"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="3.00E-32"
                     /label="AMQ36132.1_Condensation_DCL.2"
                     /locus_tag="AMQ36132.1"
                     /protein_end="2041"
                     /protein_start="1780"
                     /score="103.8"
                     /tool="antismash"
                     /translation="CYFISATIDPMRLRAGCAVVMARHSILRTAFVRTKNETSGITQVV
                     LDAPEVPFQQLHTDEDLALYCDELWQAKGTLSSTIDTLPVKFQLLSRSHAEHALVIQLS
                     HAQYDGVSLPILTSDLAAAYSVGAKSFSTTGTDFAPYVYFRSSRKSDVACNFWREYLRA
                     SSMFRLLPRRELSSVQRGPDDWPNRRVSIVRGISMPTAPSGITTASLIKAAAALVLAKR
                     ETKSDLVLGQTVNGRSMPLPGIERLLGACLNFIPFRVTF"
     CDS_motif       6313..6369
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0015"
                     /evalue="1.50E-03"
                     /label="C3_DCL_135-156"
                     /locus_tag="AMQ36132.1"
                     /protein_end="1904"
                     /protein_start="1885"
                     /score="11.3"
                     /tool="antismash"
                     /translation="AQYDGVSLPILTSDLAAAY"
     CDS_motif       6676..6771
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36132.1_0016"
                     /evalue="1.00E-08"
                     /label="C5_DCL_263-294"
                     /locus_tag="AMQ36132.1"
                     /protein_end="2038"
                     /protein_start="2006"
                     /score="27.7"
                     /tool="antismash"
                     /translation="DLVLGQTVNGRSMPLPGIERLLGACLNFIPFR"
     mRNA            complement(join(<8036..8968,9022..9495,9556..>9660))
                     /product="PsyB"
     CDS             complement(join(8036..8968,9022..9495,9556..9660))
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 337.6; E-value: 2e-102)"
                     /gene_kind="biosynthetic-additional"
                     /note="P450 monooxygenase"
                     /product="PsyB"
                     /protein_id="AMQ36133.1"
                     /sec_met_domain="p450 (E-value: 2.5e-70, bitscore: 225.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGIRSFMGLPFSAEGMVMPSYAEVLGAVLGITVSYYALYAAYCL
                     TLHPLAKYPGPKLAAITRLWHAYHLVRGTQIQALCDAHEKYGPVVRTAPNEVVFTSSQA
                     WEDIYGFRPGKGEMSKNVPDYQNAATPQSIISAEKDAHRFYRRLLSKGFSDATLRQQES
                     VFEEKIDLLVKALRDEAVQGKRPDMTHWFGFGTFDILGELAFGESFGCLEKSAFHPWVA
                     IIFQMAKWGGISQALAYYPFLLPLANRLFLGSMAEKGAVHEKLNREMVQKRMVKKNHPK
                     DLLSELLDPKHNLTQAEIDIHFSTIVLAGSETTNVALCAVIYYLARNPLAKARVIQEIR
                     GGFASADEITAISTKKLSFMQACLTEALRKFPPSAVVFPRRVPPGGDYIDGNWIPGDMQ
                     VGICVFCAHNSSLNFRDPQQYVPERWLGDERYKDDDRQAMQAFSYGPRNCLGQNLAKTE
                     LRLILARFIWEFDWELTPGTGDWDQTLVFRGWVKKPLKLVLTPVR"
     mRNA            <11321..>14847
                     /product="PsyC"
     CDS             11321..>14847
                     /NRPS_PKS="Domain: AMP-binding (90-488). E-value: 1.8e-78.
                     Score: 255.7. Matches aSDomain:
                     nrpspksdomains_AMQ36134.1_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (643-710). E-value: 4.3e-18. Score:
                     57.2. Matches aSDomain: nrpspksdomains_AMQ36134.1_PCP.1"
                     /NRPS_PKS="Domain: Condensation_DCL (775-1032). E-value:
                     1.7e-40. Score: 130.9. Matches aSDomain:
                     nrpspksdomains_AMQ36134.1_Condensation_DCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     260.9; E-value: 3.1e-79)"
                     /gene_kind="biosynthetic"
                     /note="monomodule nonribosomal peptide synthetase; NRPS"
                     /product="PsyC"
                     /protein_id="AMQ36134.1"
                     /sec_met_domain="AMP-binding (E-value: 7.8e-87, bitscore:
                     279.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.1e-14, bitscore:
                     41.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 5e-39, bitscore:
                     121.8, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCDVVLHIQTGYSSPRLVLHYRRTTMEDMHATLIVNKIEELCQFV
                     VANPNCPVSQLPMFGTWDQRLIRQWNAVDSQKPQPAPQLMHEIIHDKAQQYPELPAIES
                     WEGTITYQELDRLSTGLAGDLRQHGVRPFTFVPVLFDKTVWAIVALLAVNKAGAAFVPL
                     DPSHPLDRLKQIVERTGSTVLLASERQSNMLQEFVETQLIVSSLTVKHLPCPEDGNVSW
                     DLAPPAAPAYCLHTSGSTGNPKGCVVQQSAFSSIARHAFLLQMKPGSRVLQFASFSFGI
                     SLIEVFCTLTCGGTICMPSEVERKNNLTHAITSLDIDWALLTPTALKAFSPTEVPCLRT
                     IISAGEPMHKADVEIWAERVRLFQAYGLTEWAGIFSVSQRVTATRSMEKNIGFPVDGRW
                     WLVDPNDHARLCAVGGIGEIVIEGPSLAQGYLHDAAKTSAAFIAPPYQVIQFGGRSDDR
                     WLYKTGDLGRLNMDGSISHMGRKDAQVKIRGHRVELGEVEFHLKQSFPHAKSGVVESVI
                     ASGTGTQTLVAFIELPELWKDGESGDEVFMEPSDEFLNGALSAERLLKTRLPPYAVPST
                     FFPLRSMPLTVSGKTDRRCLRNKAASLTPQQWRQYKSLAAQQMPSTPSTPSTPSMETVP
                     TETVSTETERQLAQIWATLFGLPLEQVGPNDDFHVLGGDSVIAMRVTAMARAKGINLSV
                     TDVFANPTLCSLGRAAKTSVQTNGTGVINNPVDHLPADQMVLCLSELRERGTLPAAAQV
                     VEVLPATDIQAFFIERSGLDTFTFFLEGELDVERMREACRAVIRKHSILRTVFTKNAHG
                     LFQLILAGDHCNDPLKRIIAPKDLRSLCATLRISSPNPSLHLDHSPVGFTLASCSTTQH
                     ALIIALSHAQHDGFSINILFDDLVAAYTNASLSPAADGHHFADVVRYRAGHDRTAGLAF
                     WRNYLDGASPTRLGPSWSPVEKGTTSAVVTVDAEVPFAPTPPVGITLSTFVKAAWAVVL
                     SRHTGQTDLVFGQTVNGRNLPLVGIDQILGPCINFVPFRVRLQTNCTVREWLNYVQSQY
                     LLTTDYEDVPLQQITRTCTSWPAEHGEGLPFIFQHQNVQHQFNLEFESEDEKHRLISTS
                     CEPNLHVYPLSEDWIFSVPYETKLKLQIVARESRLPFDTASGLVRELAELVEHFARFPD
                     SMMSSLTSN"
     aSDomain        11591..12784
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMQ36134.1_AMP-binding.1"
                     /evalue="1.80E-78"
                     /label="AMQ36134.1_AMP-binding.1"
                     /locus_tag="AMQ36134.1"
                     /protein_end="488"
                     /protein_start="90"
                     /score="255.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="DKAQQYPELPAIESWEGTITYQELDRLSTGLAGDLRQHGVRPFTF
                     VPVLFDKTVWAIVALLAVNKAGAAFVPLDPSHPLDRLKQIVERTGSTVLLASERQSNML
                     QEFVETQLIVSSLTVKHLPCPEDGNVSWDLAPPAAPAYCLHTSGSTGNPKGCVVQQSAF
                     SSIARHAFLLQMKPGSRVLQFASFSFGISLIEVFCTLTCGGTICMPSEVERKNNLTHAI
                     TSLDIDWALLTPTALKAFSPTEVPCLRTIISAGEPMHKADVEIWAERVRLFQAYGLTEW
                     AGIFSVSQRVTATRSMEKNIGFPVDGRWWLVDPNDHARLCAVGGIGEIVIEGPSLAQGY
                     LHDAAKTSAAFIAPPYQVIQFGGRSDDRWLYKTGDLGRLNMDGSISHMGRKDAQVKIR"
     aSModule        11591..13450
                     /complete
                     /domains="nrpspksdomains_AMQ36134.1_AMP-binding.1"
                     /domains="nrpspksdomains_AMQ36134.1_PCP.1"
                     /locus_tags="AMQ36134.1"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       11771..11812
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36134.1_0001"
                     /evalue="3.80E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="AMQ36134.1"
                     /protein_end="164"
                     /protein_start="150"
                     /score="16.9"
                     /tool="antismash"
                     /translation="LAVNKAGAAFVPLD"
     CDS_motif       12011..12067
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36134.1_0002"
                     /evalue="2.80E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="AMQ36134.1"
                     /protein_end="249"
                     /protein_start="230"
                     /score="23.0"
                     /tool="antismash"
                     /translation="AYCLHTSGSTGNPKGCVVQ"
     CDS_motif       12557..12643
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36134.1_0003"
                     /evalue="3.50E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="AMQ36134.1"
                     /protein_end="441"
                     /protein_start="412"
                     /score="35.3"
                     /tool="antismash"
                     /translation="VGGIGEIVIEGPSLAQGYLHDAAKTSAAF"
     CDS_motif       12749..12814
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36134.1_0004"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="AMQ36134.1"
                     /protein_end="498"
                     /protein_start="476"
                     /score="36.2"
                     /tool="antismash"
                     /translation="HMGRKDAQVKIRGHRVELGEVE"
     aSDomain        13250..13450
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMQ36134.1_PCP.1"
                     /evalue="4.30E-18"
                     /label="AMQ36134.1_PCP.1"
                     /locus_tag="AMQ36134.1"
                     /protein_end="710"
                     /protein_start="643"
                     /score="57.2"
                     /tool="antismash"
                     /translation="ERQLAQIWATLFGLPLEQVGPNDDFHVLGGDSVIAMRVTAMARAK
                     GINLSVTDVFANPTLCSLGRAA"
     CDS_motif       13643..13738
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36134.1_0005"
                     /evalue="1.00E-12"
                     /label="C2_DCL_024-062"
                     /locus_tag="AMQ36134.1"
                     /protein_end="806"
                     /protein_start="774"
                     /score="40.3"
                     /tool="antismash"
                     /translation="FTFFLEGELDVERMREACRAVIRKHSILRTVF"
     aSDomain        13646..14416
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMQ36134.1_Condensation_DCL.1"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="1.70E-40"
                     /label="AMQ36134.1_Condensation_DCL.1"
                     /locus_tag="AMQ36134.1"
                     /protein_end="1032"
                     /protein_start="775"
                     /score="130.9"
                     /tool="antismash"
                     /translation="TFFLEGELDVERMREACRAVIRKHSILRTVFTKNAHGLFQLILAG
                     DHCNDPLKRIIAPKDLRSLCATLRISSPNPSLHLDHSPVGFTLASCSTTQHALIIALSH
                     AQHDGFSINILFDDLVAAYTNASLSPAADGHHFADVVRYRAGHDRTAGLAFWRNYLDGA
                     SPTRLGPSWSPVEKGTTSAVVTVDAEVPFAPTPPVGITLSTFVKAAWAVVLSRHTGQTD
                     LVFGQTVNGRNLPLVGIDQILGPCINFVPFRVRLQ"
     CDS_motif       13967..14014
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36134.1_0006"
                     /evalue="4.10E-04"
                     /label="C3_LCL_132-143"
                     /locus_tag="AMQ36134.1"
                     /protein_end="898"
                     /protein_start="882"
                     /score="13.1"
                     /tool="antismash"
                     /translation="DGFSINILFDDLVAAY"
     CDS_motif       14309..14404
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMQ36134.1_0007"
                     /evalue="1.00E-10"
                     /label="C5_DCL_263-294"
                     /locus_tag="AMQ36134.1"
                     /protein_end="1028"
                     /protein_start="996"
                     /score="34.1"
                     /tool="antismash"
                     /translation="DLVFGQTVNGRNLPLVGIDQILGPCINFVPFR"
ORIGIN
        1 ttgggttggg tttcgggccg agacctaggg cccaaattgg gctttgcgga agtccaatgc
       61 tcagtgagcg agttggtgat tatgtaatac ataggacatg ctccagtgag caaaaagtgg
      121 cgaggtcgac tactaaaacg gcaagggaac gtcaagaagt ggcagaggaa atcaagtaca
      181 taggtctggt ttctgctggc gggctcttgc tggtatgttg gcggaacgcc catatcacac
      241 agtatgggcc cctgagatga gtgctcgtgc tcctgcaact ataagcaccg gctctgaaga
      301 gtgtattatg cattcctagt ggtcccctac ctaaggccat tcctcgtgcg taagggacac
      361 ttactgcatc caagccgacc gctaaatcga ataccttcaa tgcaactcca aaaactgtat
      421 cacattgctt gccggaactg ggctctgaaa gcaaaaaacc atactagtac aaaagggcca
      481 gcaagatagc caaacaatgc atctgcatcg gcttgaatcc attatatgtg agtaaataag
      541 aagtcagacc cctacaatgc gtagccctca aatgaactca tctaatgaat tgtgtgcaca
      601 gtctcgctgt cattacgcca gtactattga ccacaaagat tgtcaaaaat atcgagaatg
      661 ccaggcacta ttgtgctgga acctaggacg ctctcgagcg aggatctctg ccgtttgaaa
      721 caatggaacg cgctcattcc ggaatcccaa gctgggtgtg ttcatcagct catcaacacc
      781 cactgcgagg aacaaccgga tgccgaggca gtgtcggctt gggacggaag ctttacatac
      841 ggagaactgg cccgagtcac tgatcatgta tcggcatact tggttgagca cggagtcggt
      901 cccgaggttg ttgttcctat attgctggaa aaatcacgat gggtgcccct ggcaatggtc
      961 agcgtgatga aggccggggg tgctttcatg ctcttagatt ccggtcatcc gcctagcagg
     1021 ctcacagaac tctgcgcacg agttggcgca gagatcatga tcacctcgcg gggattggca
     1081 gcctccagtg agtgtttagg agtgaaagct gttgcaatac tggatgagga gagcagcgct
     1141 gttcaccatc cgctctccca cggtaaaaca gccgctgtcg atgtcaaacc acgtaatctg
     1201 ttatatgttg tatttacctc gggctcgacg ggacaaccga aaggagtcct aatcgagcac
     1261 ggctcgtacg ttgcgggcgc gcagctccac atcccagcac tgcacatggg ccgctctagc
     1321 cgcatcttcc agttcgcatc caacgcattt gatgccatca tcactgatac actgagcacg
     1381 ttaattgcgg gcggttgtgt ctgcattcct tccgagggcc agcgcattga tcagtgcatc
     1441 gagaccttgg atttcttccg tgccactcat gtctttctca ctccgtcttt cgctcggacc
     1501 ttgtcacacc agcgacccag caaatttctc caagtgcttg tgttgattgg cgaggtggta
     1561 caagactctg acgttaccca gtgggcgcat aaggtaacta ttatgaacgg gtacggaccg
     1621 gctgaatgct ccgcagccgc cacggtccaa agccatttat cgtcggcttc atcgcctcgg
     1681 aacattggac acagggtttg tggcggtctc tggcttgtta atcccgacga tgtggatcag
     1741 ctagccgcca ttggagaagt tggcgagctg ctcattgaag ggccaactgt gggccggggg
     1801 tatctggatg atcctggccg gactaatgct gtcttcatac gcggccccgc ttggctgaag
     1861 caggttagag gccatgataa ccatgagaac agccgtctct atctcacagg agatctcatg
     1921 tgctacgaag cggacgggtc cttgtgctat attgggagaa aggattccca ggtcaaatta
     1981 cgggggcaac gcattgaact ccccgaggta gaggatcatg tccggcaggc ccttccgaag
     2041 aaggtcgaag ttgtagtaga gatggtgccg atcgctggta taaatcaaag tctggttgca
     2101 ttcattcaat gtgatctggg cgcatccacc gcgaatggga atggtgatag tgctgctaac
     2161 ggtgatattg ttacctacag cactggagag ttcaagaagc aggtgcttgc cgtcaaaacc
     2221 cggcttgctg caacgctacc tagcttcatg gtcccaggtt tcttcattcc tgttcagcgg
     2281 tttcccctca cgcgggccgg gaaagtcgac cgcaagaact tgagaggcct cctggctcat
     2341 gatactcact cacttgacca ttttcggatc ctagacgagg atagacgtcc cccatcgacc
     2401 gagagggagc aggcacttca gcgggtctgg agtgaggctc tgaatattgc gccggatatg
     2461 attggtgcgg aggacaattt ctttcacttc gggggcgatt ccatcacagc catattcgtc
     2521 gtggcgggcc ttcgagcagc cggctatgag ctgacggttg ctgaaatctt ggggagtccg
     2581 cggctctctc atgtcgcctc tctgatgagg gacacagcct ctatggagac gcaagcacac
     2641 atgccacctt tctctttgct tggaacccac gacgctcgag accccgccct agaggccgcc
     2701 gctagacaat gccaggtcga cgtcgatctg gtggaggata tctacccttg cacctcgctg
     2761 caggagggac tgtttgcgct tggggcgagc cagcaggggg cctacgttgg ccggtggaca
     2821 tatgccttta atgaagccac tgttgatccg agtcgtctcc ggcgggcttg gaacgaagtc
     2881 gcccagtcta atgccattct ccgaacgcga attattaaga ccccgtccca tcgcatgtac
     2941 caagtggttc tgagaaaccc cgtggcctgg gaagatccca gccggtgcac cctggaagtc
     3001 gaatttggcc gtccactggt gatgtttgcc ctgaagaaag atcctcgcac gcaatcgttc
     3061 cagttgacgg tgaccatgca ccatgcgttg tatgacgctt ggtctttaca gctcctcctc
     3121 gatcaggtgg aggccattta cctggggcaa agccaccagt caccaccacc atttaatagg
     3181 ttcgtgaaat atatcagtaa gggtatgagt gacaccaaac aggagcgctt ctggcgggcc
     3241 gagtttgctg gcctcgccgc cgaccccttc ccatcttttc agcataccca ccagcgacca
     3301 accccatctg ttacgcaccg gagaacaatc aacccagcgc aattctcgcc tcgcatgttc
     3361 actcgctcga ccgtggcacg attggcgtgg gctcttgttc aatcgcagta ccagaacaga
     3421 accgatgttg tctttggcgc cacggtttcg ggacgaaccg ccccggtctc cggggtagaa
     3481 agcatgacgg ggcccacgat tgccacaatc ccctggcggg tgcagttaca tcctgagcgt
     3541 acggtagccc aatcgttgga agaaatccag agccagaccg cccgatgtat gccgtatgag
     3601 caggttggta tgcatcacat gaagaactgg ggggaggagg cgaaggccgc atgtagtttt
     3661 cagacgttgc ttctggtgca gcaaaacgaa cgtggtgccg gcctgccttt gctcggggtt
     3721 gatgaggact cggggaattg gagggccttt gcgacgtatg ccttgaccgt tttctgtgat
     3781 ttgaactctg ccccctttgg gttggaagcc tggtttgacc ctgatatcat ccctgccgcc
     3841 caagtcgaac gcctattaaa ccagttcgct cacattatcg agggcatctg ccacggaatg
     3901 aacgccagta ttgcggatct gcttgctagc gtgtgtagca gccatgtcca gcagatgcta
     3961 gagtggaacc agatgcctga tattcctcaa gtctgtgttc atgacctgtt cgctcaacga
     4021 tgccaagaac accctgtagc attggcggta gatgcgtggg atgggacatt cacctatgca
     4081 gagcttgaca aactttccac ctccctggcg cggtatctca gcagtcgggg cgtgtgcgct
     4141 ggttggttcg tcccaatttg ctcggaaaag tctcgatggg tggttatgtg catgctggct
     4201 atcatcaaga cgggtgccgc ttttgtcctg ctagatccct cgcaccccaa gaagcgcctg
     4261 gatagtgctt gcaagctcac tcagactccg ttggtgatat gctcgcgcga cgccctcgcg
     4321 ttggccctgg accttacggg ggaagttatc gtttccagcg gcgactactc gggatggggc
     4381 gaggatttgc cgacgcaaga ttgcgtcgct ctccctaatg ttgaccctgg ccaaccgcta
     4441 tttgtggctt tcacatccgg ctccacggga atcccgaaag gcgtcctggt tacccataac
     4501 tcgtacctcg cctcgactct tcctattgtg gagcaagtaa aaatctcccc aggtgtccga
     4561 tggctccaat ttgcctcatt cgcgttcgac atgagcgccg ttgagattct ctggacgatc
     4621 atatgcggag gatgcctctg cattctgtcc gagtcgcagc ggctagacga atttgcctct
     4681 gccgccgcct cgttccagcc aacgcacgcg tttctggtgc cctcattcgc ccgcacgctg
     4741 aatccggaga ccctgccgtc tctccgtgcc ctcctcctgg ctggcgagcc tccgaatgca
     4801 ggtgatatcc agctctggtg cgagcgagtc tcgctgatga atctttacgg accggccgag
     4861 acaggcataa cccatgggct ataccactac acccaatcga cagctccaac taatgtcgga
     4921 cgcaacaccg gaagcgccac gtggttggtt cacccggacg accccgagcg gccggtaccc
     4981 attggggcag tgggcgaagc gctgatcgag ggacctaatg tgggtcctgg atatctacgt
     5041 gatccggaga ggacggctgt tagcttcatt caagtgccaa aatggcttca aggtcttcga
     5101 ggtagaagcg atggaattgt gtacctgact ggggatcttt ttcggtgcga tgaggatggt
     5161 tgttacatct atctcggccg taaggacaat caggtcaagc tacgaggcca gcgaatcgag
     5221 ctaggagatg tggaaacaca tgttcaaact gcctttgatg ccggcagctt ggtgattgtg
     5281 gaactggtga cccaggcggc cggcataacc cagccttgcc tagtcgcttt tatcttcaac
     5341 ccctcccttc aagaccgcat ggatgatctc ttttctgcgc caaacacgca gttcagtgca
     5401 caagtggttg tagtcaaaga ccggctgcag aaagccctcc cgcgcttcat gataccctct
     5461 tatttcattc cgctttccta tatccctcgg acgacgagcg gcaaggtgga tcgacgtcaa
     5521 cttcgacttg cactcagcac actaccagag caacagatta cagagtatct tgccacaact
     5581 gccaagcgag agccttccac cgagatagag aagaggttgc aacacctgtg ggcgaaaggg
     5641 ctccgattgg cccctgagga tatcggagtg gacgacaatt tctttgacgt aggcggcgat
     5701 tctatcaagg cgatgtatct ggccgccaca gctcgtgacg aagggctagc attgactgtg
     5761 acggatatcc tccaaactcc cactttgtct gctcttgcgc aacagtgtac gcccttgcag
     5821 tcgctcagta cgccagaggt agtcccattt tcgcttgtgg acgagcctac taaatcattc
     5881 gtaacacaga gggtgcaaga tttggggatc atctctggag aggcccacat tgttgatata
     5941 taccccgcca ccgaaggcca acgatggctt attgatcaat ggagcccagt tcatttctgc
     6001 tattttatct ctgccacgat cgatcctatg cgcctgcggg ctggttgcgc tgtggtaatg
     6061 gccaggcata gcattctccg gacggcattt gtcaggacta agaacgagac ctcaggcatc
     6121 acccaagtgg tcctggatgc tcctgaggtt cccttccaac agcttcatac cgatgaggat
     6181 cttgcacttt actgcgacga gctttggcag gcgaagggga cgctgtcttc gacaatagac
     6241 actctgccgg tcaaattcca gctcctctcg cggtctcacg cggaacacgc cctggtgatc
     6301 cagctctcac atgcgcagta tgacggagtc tcgcttccga tactaaccag cgatcttgcc
     6361 gctgcctatt ctgtcggtgc caagtcgttt tcaacgaccg gaaccgactt tgcgccgtat
     6421 gtctacttcc gatcctcgcg caagagtgat gtcgcctgta atttctggag agagtatctc
     6481 cgtgcgtcgt ccatgttcag acttttgcct agaagagagc tgtcgtccgt ccagaggggc
     6541 cctgacgatt ggcccaaccg tcgggtctcc attgtgcggg gaatctccat gcctacggct
     6601 ccatctggga ttaccacggc ctcgctcatc aaggccgccg ccgcccttgt tctcgcaaaa
     6661 cgagagacca agtctgactt ggtcctcggc caaacggtga atggtcgcag tatgcccctt
     6721 cccggtattg aaaggctcct aggcgcatgt ctcaacttca tacccttccg ggtgaccttt
     6781 gagcccggct ggtcagcgat ggacttgcta catcacaccc atgcgcagtg cacccagacc
     6841 ctggaatacg actacatggg tctgtcggaa attctacagc agagctccga aatgccccca
     6901 ggcacgcagt tcggctgtgt tgtgcagcat cagaatattg cccagacagg cgagcagggt
     6961 cccgagctgg ttctggacgg agtcacctgc caatcttccg cgctagcaaa cttcaatcct
     7021 atgtctgggc tatggatact ttctacgccg cgtggtgagt ctttggaggt aatgacttgc
     7081 acggtggaag agcttctctc gcctgcagag gcgaggggtt tgaacgatga gctctgcgag
     7141 acgatcatgg atttagcgca gaatccagat gctagcctgg accttaacat ttggtaatgt
     7201 aagctttatg tgttgtcgga ggatcaggtg atcccacata tggatcagga cttccataac
     7261 ttgcctttct ctctgtttct tctctcttct tttgaccatt tctgagcagt tcgatagtac
     7321 catacattac tacattgctt ccctctctgt ttctccgccg tcatgtgtcg ccaatgattt
     7381 atgaacgtat ggcgacggca tggttttcta cagggtccac tgtcgtaata acgagccccg
     7441 tcatacagcg ttctactccg catgatgctc aggtggggaa tcttaaagca gaatctttgc
     7501 atggatccag tatatcaaac ataaggggag acagacctca atccccagcc agtaaacggc
     7561 tgttgatgtg tagatcaggg agcaggtatg gcctcgaggc ccgccccaag cgattctacc
     7621 atgtagccca atcactgtac gatattgcag ggactacctt gttatggcac gaccatctac
     7681 agacatttct acatggatgg aggatacacc gagtcattcc gcctgacccc accggtgcct
     7741 tacattggca aaacaatatg caagcaaagg gctagattcc tgggccagat tcctggatct
     7801 ctcaatatag taataatctc tgggaaacat tctttctgat gcaaggtccc ccacttctga
     7861 actacaacgg cgactgagtc catggcgcgg tgggctcagg ctcatatcat gaccaaagtg
     7921 tgtgccattg ggagaacaaa ctgggaccta gattggcatt tttcctcgga cacaacacga
     7981 taatgttatt caaaccaagc aagatagcaa atacgccgat gtaaagccgg gacacctagc
     8041 gcaccggcgt aagaacaagt ttcaggggtt tcttcaccca gccccgaaag acgagcgtct
     8101 gatcccaatc ccccgttcct ggggtaagtt cccagtcaaa ttcccagata aaacgggcca
     8161 ggatcagacg caactctgtc ttggcgaggt tctgcccgag gcaatttcgc ggaccatagc
     8221 tgaacgcctg catcgcctgg cggtcgtcgt ccttgtacct ttcgtcgccc agccaccgct
     8281 cgggcacgta ttgttgcgga tcccggaagt tgagcgagct gttgtgtgcg cagaagacgc
     8341 aaattccgac ttgcatgtct ccggggatcc aatttccatc gatatagtct ccacccggag
     8401 gcacgcgacg cggaaacacg accgcggacg ggggaaactt ccgcaaggcc tcggtgagac
     8461 atgcctgcat aaaggaaagc ttcttggtgc tgatggcggt tatctcatct gcgctggcaa
     8521 acccaccgcg tatctcctgg attacgcggg ctttggctaa gggattccgg gccaggtagt
     8581 agatgactgc gcagagggcg acatttgtcg tctcgctgcc ggcaaggacg atggtagaaa
     8641 agtgaatgtc gatctcggct tgagtgagat tgtgtttggg gtcgaggagc tccgagagga
     8701 gatccttcgg gtgattcttc ttcaccatcc gcttttggac catctcgcgg ttgagcttct
     8761 catggacggc gcctttttcg gccatggacc ccagaaacag tctgttggcg agtggcaata
     8821 ggaacggata ataggccagc gcttgactaa ttcctcccca cttggccatt tggaagatta
     8881 tggctaccca tggatggaag gccgactttt ccagacaacc aaatgattct ccaaaagcca
     8941 actcgcctag gatatcaaac gtaccaaact gcagaggtca gtagctatcg gccaggtctg
     9001 ggaagcatcg taagcactca caccaaacca atgagtcatg tccggtctct tgccctgaac
     9061 ggcctcgtca cgcagggcct tgaccaacag gtcaatcttc tcttcaaaca cagattcctg
     9121 ctgtcgcaag gtagcatccg agaatccctt cgaaagcagg cgccgataga agcgatgtgc
     9181 atctttttcg gcggatatga tgctctgcgg cgtggccgca ttctgataat ctggcacgtt
     9241 cttgctcatc tcgcccttgc caggtcggaa gccatagata tcttcccatg cttgactgga
     9301 agtgaagacg acttcgttgg gggcagtccg cacgacgggg ccgtacttct catgcgcatc
     9361 gcacagagcc tggatctgcg tcccacgaac caagtgatac gcatgccaga ggcgtgtgat
     9421 ggcagcaagt tttggacccg ggtatttggc aaggggatga agagtgaggc agtaagcggc
     9481 ataaagagcg tagtactaag cgaatgaata atcatggtta ttcggaggcc ctcaggtttc
     9541 tgaagagtaa cttaccgaca cggtgatgcc gagcaccgcg cctagaactt ctgcgtacga
     9601 aggcatcacc attccctccg cagagaaggg taggcccata aaagatcgta ttccgtccat
     9661 cgatgagaga cagttaccat atctgtccac cagagattgc atttacagca gggggatgcg
     9721 ccatccattg tgttgggcac attatataca atatattcgg tgcgtggagt ctagactgga
     9781 gcgaccatga attgatggaa tccgcatgct tagagatgca aggggttgag ccccaaagat
     9841 gtaactttta cgaagtctct ggacttacca aaacatcaaa atccatcgag ctcaccgcta
     9901 gagtaaagag gctggcctag agcacttgag tctaagcgca tgcctcacct ggttaagcca
     9961 acgacctctt cttgcacaaa atcttgccaa tggtctcaaa cccacactgc gacgtggtaa
    10021 aataggcaaa tactgcgtct aaagcaatca tcacccaaac agcccacgat ctatagcgac
    10081 cagcatgaga gccctgcagc taaggggaca tacgtacctt ttgtaacctc cctcgagacc
    10141 tctataggta ctatacagag tatacttagg tagatcaata cttgtacact ggagactgca
    10201 ggatgctgtg ggtctagggg tcacgggtcc ccacaacggg cgccatgcat gagaacggag
    10261 cggtgatcat cttgatcgaa tatcaatttc cgattacggt gaggcatttg ggttattggg
    10321 gatttattcc ggcttgaaga gctcacaatc cagcagcctt gatttgtgcg ctgcactgta
    10381 catacatgca aggtgcacgc ttgcgaacca agtaaaatgc taaggctttc ttccaaaaca
    10441 ctacctaatg atgcaatggg atcgagtaca ctcaatcgcc cagattcctc cttacccttc
    10501 cttggctggc catgtagttc gcatgaattg ataccgacag tcagcggtca gagcctgcta
    10561 caggctacct aggtatgcaa gcacaagtct tcattccaca tccatgcaag ggttcaattc
    10621 atcaatgatt tcagcacgcg cttaggcacg aggcagcaga tcagggggag caaacattcc
    10681 caggaagaaa gaaggcaatt cttcatcttc agggcttctc gtggacgaat attaaaatct
    10741 accttgcaac cgcaaccctt cttcatgttt catgtactac gctgctagaa tgacagttat
    10801 atccatggac actgtggccg gaatcggcaa agccctgacc aaccacagca agcatgaaca
    10861 agaacaacag tcctgcatct ttccagctct cactgacgac gcttcttctt ctcaacgatg
    10921 ggaaacattg aatatttcgc gtgttcaagc gggcattgcc cttcagtatt gggataaacg
    10981 tggtctaagt catcatctgc ttgggacagc gatctgggcc accatcctcc gtcagttgtc
    11041 cgacatgaat tcacctcaga tctggctgca agccgagggt gcctcagccc cgagattgct
    11101 gatgactcgg tttggcgaga gggagaaatt cgcatccttg tcggattgga gcgtgtgggg
    11161 gtcgttcata gacgaagcta acgccgacta cgaacgaaac actgggttgc tggtgagcga
    11221 tgatttggaa tcctgtgatt cttacaggtc atcttgcatg ctattcaagg taagcggctc
    11281 agttcattga tgtttggacg aaactgaacc gttcgatcag atgtgtgatg tggtcctcca
    11341 cattcagact gggtacagct caccacggct agtgcttcac taccggagaa caaccatgga
    11401 ggacatgcat gcgactttga tagtcaacaa gatcgaagag ctctgccagt ttgtagtggc
    11461 gaatccaaac tgcccggtca gtcaattgcc catgtttggt acttgggacc agcgcctgat
    11521 acgccaatgg aatgctgtcg actcccaaaa accacaacca gcacctcagt tgatgcatga
    11581 aataattcat gacaaagcgc agcaataccc tgagcttccc gctattgagt cgtgggaagg
    11641 aacgattacg taccaagagt tagatcgtct gtccacaggt ctagcgggag atctgagaca
    11701 acacggcgtg cgcccgttca ccttcgttcc agttctcttc gacaagaccg tctgggcaat
    11761 tgtagccctg cttgcagtga acaaggccgg ggctgcattt gtcccacttg acccttctca
    11821 tccgctggat cgcctgaagc agatcgtcga gaggacaggg tccacagtcc tactcgcgtc
    11881 tgagcgtcag tccaacatgc tgcaggaatt cgtcgagacc cagctcatcg tgtcatcgtt
    11941 gactgtgaaa catctacctt gtccagaaga tggcaatgtc tcatgggacc ttgcaccacc
    12001 ggctgcgcca gcgtactgcc tccacacatc gggcagcacg ggtaacccta aaggatgtgt
    12061 ggtgcaacag tctgctttct ccagcatcgc ccgccacgct ttcttgctgc agatgaagcc
    12121 cggcagccgg gtgctgcaat ttgcatcctt cagcttcggg atctccctga ttgaggtctt
    12181 ctgcacgttg acttgtggag ggaccatctg catgccttca gaggtagagc ggaagaacaa
    12241 tctcacccac gcgatcacca gcctggatat cgactgggca ctgctgaccc caacggcctt
    12301 aaaggccttc tccccgactg aggtcccgtg tctacggaca atcatctcgg ccggagaacc
    12361 aatgcacaag gctgacgtag agatatgggc tgagcgcgtc cggctcttcc aggcgtatgg
    12421 attgaccgaa tgggcgggta tattcagtgt ctctcaacgg gtcaccgcca cacggtccat
    12481 ggaaaagaat attggcttcc ccgtggacgg tcgttggtgg cttgtcgacc cgaacgatca
    12541 tgccaggctt tgtgccgtcg ggggcatcgg cgaaattgtg attgaaggcc caagtcttgc
    12601 tcagggctat ctacacgatg cggcgaaaac ttcggcggcc tttattgctc ccccgtacca
    12661 ggtgatacag tttggtggaa ggagcgatga tcgatggctc tataagaccg gcgacttagg
    12721 ccgtctgaac atggatggta gcataagtca tatggggcgc aaggatgcgc aggtcaagat
    12781 ccgtggtcat cgagtcgagc tgggtgaggt agaattccac ttgaaacagt cattccctca
    12841 tgccaagagt ggagttgtcg agtctgtcat tgccagtgga acgggaaccc aaacacttgt
    12901 ggccttcatt gagttgcccg aactatggaa agatggggaa tcaggggacg aagttttcat
    12961 ggaacccagc gatgaattcc taaacggagc cctttcggcc gagcggttgc tcaaaacgcg
    13021 tcttccacct tacgctgtgc catccacctt ttttcctctg aggtctatgc ctctcaccgt
    13081 gagcgggaaa acagatcgtc gctgtctgcg gaacaaagct gcctccctca cgccacagca
    13141 gtggaggcaa tacaagtcac tggcagcgca gcaaatgccg tcaacgccgt caacgccgtc
    13201 gacaccgtcg atggagacag tgccaacaga gacagtgtca acagagacag aacggcagtt
    13261 ggcccagata tgggccactc tattcggcct tcctttagag caagttggac caaacgatga
    13321 cttccatgtt ctggggggcg actcggtcat cgcgatgcgc gtcacggcga tggccagagc
    13381 caaagggatc aatctttcgg taacggacgt tttcgctaat ccgacacttt gctccttagg
    13441 aagggccgct aagacatctg ttcagacaaa tggtacaggg gtcattaata atccggttga
    13501 ccacctgcca gcggatcaaa tggtgctatg tctgtccgag ctgcgggagc gaggaaccct
    13561 cccggcagct gctcaagtgg tcgaggtgct accggcgaca gacattcaag cattcttcat
    13621 tgagcgttct ggactcgaca cgttcacttt ctttttagag ggtgaactag atgtcgagcg
    13681 gatgagggag gcctgccgtg ccgtgatacg caagcacagt atcctccgca ctgtcttcac
    13741 caagaacgcc catggcctat tccaattgat cttggccgga gatcattgca atgaccctct
    13801 caaacgcatc attgccccca aagatctgcg cagcctctgc gcgaccctcc gcatcagcag
    13861 tccaaaccct tccctacatc tagatcatag ccctgttgga tttaccctcg cctcgtgttc
    13921 cacgacgcag catgcactaa tcattgcact gtctcacgcg cagcatgatg gtttctccat
    13981 caacatcctg ttcgacgacc tcgtcgctgc gtataccaac gcgagtttgt ctcccgcagc
    14041 cgatggccac catttcgccg atgtggttcg ctaccgcgcc ggccatgacc gcacagccgg
    14101 actggccttt tggaggaatt acttggatgg ggcatctccc accaggcttg gaccttcatg
    14161 gtctcctgtg gagaagggaa caacttcagc ggtagtcacg gttgacgccg aagttccttt
    14221 cgcgcccacc cctccggttg gcatcacgct ttccactttt gtcaaagccg cctgggccgt
    14281 cgttctgagt cgacacaccg gccagactga tttggtcttt gggcagaccg tcaacggccg
    14341 caacctgccg ctcgtcggca tcgatcagat cctcgggccc tgcatcaatt tcgttccgtt
    14401 tcgggtccgc ctacagacca actgtacggt gagagagtgg ctcaactatg tgcagtcgca
    14461 gtatctcctc accacggact atgaggatgt tcctttgcag caaattacta ggacatgtac
    14521 atcttggccc gccgaacatg gggaggggct cccattcatc tttcagcatc aaaacgtcca
    14581 gcaccagttc aatctcgagt ttgaaagcga agacgagaag cataggttga tcagtacatc
    14641 gtgtgagcca aatcttcatg tctatccgct ctctgaagac tggattttct ccgtcccata
    14701 tgagacgaag ctcaagctgc aaattgtggc gcgggagtcg cggttgccgt ttgatacagc
    14761 ttccggtctg gtgagagaat tggcagaatt ggtagagcat ttcgcgcggt ttccggatag
    14821 catgatgtcg tctctgacta gtaatttgtg aggatgtaat aatgttgtat cacagcactt
    14881 ttctttgccc gggatggcgc atcgagcaac ttcataactt catatgctct tgttgagcag
    14941 gtcagtaagc ccacacccat gctcaccagc cacttcaccg cgctgcagag tctggtttga
    15001 gaagatggta ttatatttcc aaatttcttg gcctgactgt cttactagat atctggtctc
    15061 agtcgctact gtgttttctt ggactgtatc tcaggggact tccagcctag caagaataat
    15121 gttctttctc tcttattatg atgatggtgc caagccaacc atcgacatgc ttggtatgac
    15181 gcggtaagag taagaaaata gtgtcaggga gctgaaccat caattttcaa cgatgacaga
    15241 gacaatgtcc gcatgtacca tatactgaat ttgatctgct atctagtaaa tctcttttat
    15301 gagctttctc acggaattca ctttcaggta cgtagcctcg atactggaag agcaaaggtt
    15361 ttgactggaa attaatcagg cagagagatt gattacgtgc atgaatgatt aatgcccgct
    15421 gtgcattctc taaccacgat tattgcttca ttgacagtta tctattccaa aggactagta
    15481 tgaacggttt cgagtggcca gttcctcaca gagcagagat ctcatacgcc ctagcaatat
    15541 gactcgttag atcggctaga agatacgggt ttctgttgaa ctgactgtgg tggcatatgg
    15601 atcgctccgc aactgttgcc aaatttcttc cacactattg gcataaaggg caatgacgtt
    15661 ccccagcctg ctttgctgag atccggtcat agacgactgg cttatgattt catccagaaa
    15721 tgtctggtga gtggtggaga ttggaatatg tttcacgatc gttcggtcag cgctcgggca
    15781 gtcttgaatg actaccaaat tataaaggga agtcagaccc atgagaagga tgcgagactg
    15841 cgggaagatg aaagttttat tcctgccatc caatagcacg aggaatcgtg gtatacgtcc
    15901 cctttgcgat ttgggtaatt gtaagcctag aggccatagt agctatcaga caatgatttt
    15961 gaaagggtct aacaagggag gtgcctgagc agaggtggtg agaagtattc gcggcccacc
    16021 gctatggctt gcaatctctt gaataccaaa aatagggtag cattccttga ctgctggtat
    16081 aatataaaat attgatttta cttaattaaa agttctagaa gtaagggatg cacgaggcga
    16141 aaacacaatg tgtttcaccc acttccgtac attctaccaa cccaattcag ttcccataga
    16201 tcttggccgc acctagacct ccggatagta cgccatattc cacccatagc tttcaatagt
    16261 ctttattctc ttccgctgct ccttgtgaag ctatcactct tattttcgcc tgtccgatca
    16321 tgccaaaacc agttcacgtt gatgctgcaa agaagatgca agagtggttg gttattctcc
    16381 gggataagcc gaatgtagta agtaggtggc tcacttatct accaagattg gaaattcatt
    16441 ctttgtactg ggacatcgcg cgagtttctt acacagggta ttatagctct ccaggcgcat
    16501 cgccatccgc cccaagcatt cacctaattt tgttcgttta caccacgatg aatatgtgtc
    16561 ttgggcaggt taggagttct tgttcgccgc actttcacaa cgacccattc atcctgactc
    16621 aacagtttat gataataggc cccatctttt ccagcccatt tgtcaaagga ctggtcgaaa
    16681 cccgaccatt tatcggtagt gtcataatga tcaatgatac gagcccgcaa gcaattcgag
    16741 aaaaactcaa aggtgacatc tatgcgcagc aaaagatatg ggactgggac cgggtggaga
    16801 tcctaccctt taggactgtg cagcggggct ctgcgaacaa tgcagggaaa tgaaataaat
    16861 caggtcccag aaaatcaaaa tcaaatacaa gacatgtaac acgcaagctt tagttgtctt
    16921 tttcagttga ctggatagct ctttaatggc tatcgacact gatctcttcc tttataccgt
    16981 gatacatgta acagaattat tggaagcttc atatcggaaa tcttcgcgcc tgggggctcc
    17041 cattattacc atctccatag caatagacac ctcttacagc actaacgcac agctgcatgc
    17101 cttacaataa cgtgtttaat gactagtcac acactgccca tcgtttcgtg cgcattagtc
    17161 tacagaattc gtac
//
