BGC0002617 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002617 (Penicillium sp. YT-2016)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	17,174	psychrophilin D/psychrophilin H/psychrophilin F/psychrophilin C/psychrophilin G/psychrophilin E/psychrophilin A/psychrophilin B/psychrophilin I	NRPS:Type I	100%

BGC0002617 - Region 1 - NRPS

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Location: 1 - 17,174 nt. (total: 17,174 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 17,175
Label		BGC0002617

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002617	1.00	NRP	psychrophilin D, psychrophilin H, psychrophilin F, psychrophilin C, psychrophilin G, psychrophilin E, psychrophilin A, psychrophilin B, psychrophilin I	Penicillium sp. YT-2016
BGC0002157	0.33	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0001249	0.33	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900	0.33	Other	ferrichrome	Aspergillus oryzae
BGC0002199	0.30	Alkaloid	nanangelenin A	Aspergillus nanangensis
BGC0001261	0.29	NRP	AM-toxin	Alternaria alternata
BGC0002710	0.27	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0001718	0.27	NRP	okaramine D	Aspergillus aculeatus ATCC 16872
BGC0000313	0.26	NRP	beauvericin	Beauveria bassiana
BGC0000342	0.26	NRP	enniatin	Fusarium equiseti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002617	1.00	NRP	psychrophilin D, psychrophilin H, psychrophilin F, psychrophilin C, psychrophilin G, psychrophilin E, psychrophilin A, psychrophilin B, psychrophilin I	Penicillium sp. YT-2016
BGC0002157	0.67	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0001249	0.66	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900	0.66	Other	ferrichrome	Aspergillus oryzae
BGC0002199	0.63	Alkaloid	nanangelenin A	Aspergillus nanangensis
BGC0001261	0.62	NRP	AM-toxin	Alternaria alternata
BGC0002710	0.61	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0001718	0.60	NRP	okaramine D	Aspergillus aculeatus ATCC 16872
BGC0000313	0.60	NRP	beauvericin	Beauveria bassiana
BGC0000342	0.59	NRP	enniatin	Fusarium equiseti

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 17174:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AMQ36132.1

AMP-binding (40..442): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DATFVIGAAK
Nearest Stachelhaus code(s):: Val DALFAGGALK (56% 8Å match); Phe or Tyr DAACVAGVAK (53% 8Å match)
Stachelhaus code match:: 60% (weak)

AMP-binding (1117..1516): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMVFLALITK
Nearest Stachelhaus code(s):: Ala DCFFFALITK (41% 8Å match)
Stachelhaus code match:: 70% (weak)

AMQ36134.1

AMP-binding (90..488): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GIILIAAGIK
Nearest Stachelhaus code(s):: 4clBza or 2clBza GVIILAAGIK (74% 8Å match)
Stachelhaus code match:: 70% (weak)