LOCUS       BGC0002621              9218 bp    DNA     linear   BCT 04-SEP-2021
DEFINITION  Streptomyces angustmyceticus strain JCM 4053 angustmycin
            biosynthetic gene cluster, complete sequence.
ACCESSION   BGC0002621
VERSION     BGC0002621
KEYWORDS    .
SOURCE      Streptomyces angustmyceticus
  ORGANISM  Streptomyces angustmyceticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 18:06:16
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..9218
                     /db_xref="taxon:285578"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces angustmyceticus"
                     /strain="JCM 4053"
                     /type_material="type strain of Streptomyces
                     angustmyceticus"
     misc_feature    1..9218
                     /note="angustmycin biosynthetic gene cluster"
     subregion       1..9218
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002621"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..9218
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            255..1562
                     /gene="agmT1"
     CDS             255..1562
                     /codon_start=1
                     /gene="agmT1"
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 238.9; E-value: 1.1e-72)"
                     /gene_kind="transport"
                     /note="AgmT1"
                     /product="MFS transporter"
                     /protein_id="QZN83605.1"
                     /transl_table=11
                     /translation="MEPSDELTPPHAPSRPPGQGPSAWARRLASGVPQGRAARIFLLVA
                     FVDAAGRGIFLAGSALFYTQVIGLTNAQVGLGLSIAGLVGLVCAVPIGWLADRFGDGPV
                     LVALQLWRAAAFLVYPLVDDFRWFLVVACLVGAVEWAAMPIIQSVAGATSEEGSMVGAM
                     AVVAVARNSAYALSALAATAVITWASPRAYVAFVFVNALGFLVSGILLLRLRLPRRATD
                     HMPRERGAKLLPFKDVRFVLLSLTNGILYAHMPILSVAFPLWIVTRTDAPRALVGVALT
                     INTVMAVLLQIRLSKGGDELRRAGRKQRLAGLALAVFCLLVACTRSVDGVTATALLLLA
                     AVALTLGELWQSAGGWGISYGLAPEAQRTYYLSVYQLGATGVTVAGPAVLVMAVVDVGP
                     AGWIGLAALLALTGLVTPALTRPPRRRAAAAAAPAD"
     gene            complement(1596..2795)
                     /gene="agmT2"
     CDS             complement(1596..2795)
                     /codon_start=1
                     /gene="agmT2"
                     /gene_functions="transport (smcogs) SMCOG1184:major
                     facilitator transporter (Score: 355.9; E-value: 3.3e-108)"
                     /gene_kind="transport"
                     /note="AgmT2"
                     /product="MFS transporter"
                     /protein_id="QZN83606.1"
                     /transl_table=11
                     /translation="MPLAILALAISAFAVGTTEFVIMGLLSDVAADLSVSVPVAGHLVS
                     GYALGVVAGALPLAALTTRLPRRAVLVLLMSVFVGGNLLAGVAPGYGLLLAARVLVSLA
                     HGAFFGVASVTAADLVAPDRRATAISLIFSGMTVSTILGVPLGTLVGQHFGWRATFLSV
                     ALVGFLGLLSILVLLPARPRPAAGGLRTELRAFRRRQVWVTLLVTTLVSAAIFASFTYI
                     EPMLVTVTGFAPAAVTVILMLYGVGMSVGNLLGGHFAGKFPVGTLHTTLTALAVLLAVL
                     AYSIHFRTPAVITLTLLGLCGTAAIPTLQHRIMQVAPTARTLASAANVAALNVGNALAA
                     WLGGLAIDAGFGYASPNLVGALLAIAATVIAVVTHLTGPGPDAERTTPRTGTQAPTRAP
                     "
     misc_feature    complement(2601..2603)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(2856..3728)
                     /gene="agmR"
     CDS             complement(2856..3728)
                     /codon_start=1
                     /gene="agmR"
                     /gene_functions="regulatory (smcogs) SMCOG1078:LacI family
                     transcription regulator (Score: 197.2; E-value: 7.3e-60)"
                     /gene_kind="regulatory"
                     /note="AgmR"
                     /product="LacI family transcriptional regulator"
                     /protein_id="QZN83607.1"
                     /transl_table=11
                     /translation="MAKKVLDAAVDMGYRLNLSARSLRLGRTGTVMLVVPSLTNPHFAD
                     VHSGAARAGAERGIGVIVYPLNGEDGKGPFPFPRQAIDGVLACAVSADSIDRLRDGVAM
                     VALDSDPDAGVCSVTMEVAAGMRSAVDHLVRLGHRHLLHVRAQRDAWTFTQRTAAFDGR
                     IAAHPRVRGRSLAVPFDGARTRELILARLRDDTSVTGIICDDDNLAACAYSAAHGLGLS
                     IPGDLSVIGFDDLPLASLLVPALTTVRLPSQELGRLGMERFLRHDTATARTVLPIEFVE
                     RASVGPPGR"
     misc_feature    complement(3654..3656)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4029..4610
                     /gene="agmA"
     CDS             4029..4610
                     /codon_start=1
                     /gene="agmA"
                     /note="AgmA"
                     /product="adenosine 5'-monophosphate phosphoribohydrolase"
                     /protein_id="QZN83608.1"
                     /transl_table=11
                     /translation="MKSAVTVYCGASLGEHPGYADAARQLGQALARADMDLVYGGASTG
                     LMGCVADAALLGGSRVTGVIPQSLVRFEVAHTALTELRVVDTMHERKALMAQLGDAFVA
                     MPGGFGTAEELFEVLTWAQLGLHAKPCALLNTNGYYTPLLRFLEHAAGEGFVHRRYLDN
                     VIVEEDPHVLLSRLSGHRALPHLFEEVAEA"
     misc_feature    4104..4106
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4607..5281
                     /gene="agmB"
     CDS             4607..5281
                     /codon_start=1
                     /gene="agmB"
                     /note="AgmB"
                     /product="HAD-like hydrolase"
                     /protein_id="QZN83609.1"
                     /transl_table=11
                     /translation="MTTARRPAAAGAPSRPSDAASPAPALAVFDLDGTLLPETTSCREI
                     ARVVGRHADIHDLEAAYGRGEIDSRAFAVSALRCWSSGGETVYRRAFEAARFLDGIQDC
                     LTWLRAQGTTTVLVTMSHREFAECFDGFDRIFASDYPRDILDPEDKPLIVDRLRAGLGI
                     TPDDVIAFGDSMSDLPLFRTLPRTVAVNASPALTELAAYHYRGDDLREALRLVCPAAEF
                     VS"
     gene            5278..6357
                     /gene="agmC"
     CDS             5278..6357
                     /codon_start=1
                     /gene="agmC"
                     /note="AgmC"
                     /product="D-allulose-6-phosphate pyrophosphokinase"
                     /protein_id="QZN83604.1"
                     /transl_table=11
                     /translation="MSARHPTGRTAAAATEPPPAGTGALTVLCRSFADDFPGGLDAFHD
                     ALGRRGLTTEVHERVDGRFPDGELCVDLPGDPTGAHVLVHQSLTGPAEQVDRSVLALLA
                     VARAYREHGARKVTAVVPHLAYARHDRHVPGERRPIMAGLLAQLAATAGIDTLITLASG
                     AEDRLGPLSGPLNLVQLPSDQALLALVRPWVLPGRTVLVAPDAGAARQVRRLGDRLHLP
                     VVTATKRRTGPDSVTAALTSSPPGPADRVIIVDDLITSAGTMLAVARLVRAEFEGCQVL
                     CAATHLRPTATGEQRLAAALRDGTLHRVLTTDAAGHRPRITGLDVTAVLPLIADAVASH
                     VLPDHAPLAERPTAHAGSH"
     misc_feature    6319..6321
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6341..7060
                     /gene="agmD"
     CDS             6341..7060
                     /codon_start=1
                     /gene="agmD"
                     /note="AgmD"
                     /product="D-allulose 6-phosphate 3-epimerase"
                     /protein_id="QZN83610.1"
                     /transl_table=11
                     /translation="MPAPTELLESVPPTALSPVLSMSVVCLDQTRLGAHIETLRTLGIS
                     RLHVDLIDPAFGRNVGLPLETISDLAATCGLPIDVHAMLHRPGDLLEQAAQRGAATVCV
                     HQRTVTPEVLDCLRRIAAGPTEVGLVVDPGEGIDRALVERLNPAQLTVMSVEPGGAGRP
                     FRDEALLTLAEAAELRERGTVQRVEADGAVGPATVARLVSAGAGQLVLGSTVFPQRGPA
                     DNRLDELALALSALSPA"
     misc_feature    6689..6691
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7112..7648
                     /gene="agmE"
     CDS             7112..7648
                     /codon_start=1
                     /gene="agmE"
                     /note="AgmE"
                     /product="adenine phosphoallulosyltransferase"
                     /protein_id="QZN83611.1"
                     /transl_table=11
                     /translation="MTPTHPITIGDVRRELPIVRVADDARIAFLKLYGDVELTVACARA
                     LAERMPTDIDVIVGPETGGILLAHELAEHSGRPYAIARKKLRPNMVKPLRVPVQSIGTP
                     GRQELFLGDDDVALVEGRRVALVDEVVSSGGTLTALHELVATAGGTVRQVLAVATEGER
                     RPEVESLLHLPVFPG"
     gene            7722..8993
                     /gene="agmF"
     CDS             7722..8993
                     /codon_start=1
                     /gene="agmF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /note="AgmF"
                     /product="hydrolase"
                     /protein_id="QZN83612.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 1.8e-12, bitscore:
                     36.2, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPTIHASEVADMGLADHGEGLCDWSAQSMPILARLRERYAAEKP
                     FAGRRIAIAVHITTETANLALTLQAGGAEVFLCASNVRTTNDAVAAYAARQGVHVHGIQ
                     GEDRETYAAHCHRVLDARPHLVIDDGADLTGLLHGARTDAASDVVAGLEETTAGIQRIR
                     SLEADGLLRYPVIAVNEARTKHLFDNRYGTGQSTMDAVLRLTNTLVAGSRVVVAGYGMC
                     GKGVAARARGMGADVLVTEVDHVRALEAVMDGYRVMEMDRAAELGDLFITVTSSKNVLR
                     AEHFALMPDGAIVCNSGHFDVEIDVPALRAAARKHTRPRPGVDQYTLANGRRITLLAGG
                     EVVNLAAAEGNPATLMDMSFTNQVLGCEYLLRNAAHMDRRVHALPADIDDHVADLKLRT
                     LGVGIDTLSEEQIAYLRSWDQGSA"
     misc_feature    7827..7829
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 gcgaactcct ggggctctcg tccgccgaac gggtgctggg ttccctggac atcggcaccc
       61 ccgacgagaa ggcgcggcgc tcgcggcggc cgcgcgagga cgtggcggcc aaggtctcgg
      121 ccttcgacgc cgcggcggtc accgccgcca ggacgggcgg acccgccggt ccgtgacagc
      181 gggagcccgg cggcggggcc ctcgcagatc cgacgtaccc ggcccgtgcc ggacgagaaa
      241 ggcagcacgt accagtggaa ccgagtgacg agttgacgcc gccgcacgcc ccgtcccgcc
      301 cgcccggaca gggcccctcc gcatgggcgc ggcggctcgc atccggcgtt ccgcaggggc
      361 gggcggcgcg tatcttcctg ctggtcgcct ttgtcgacgc cgcgggccgg ggcatcttcc
      421 tcgcgggctc cgcgctcttc tacacacagg tcatcgggct gaccaacgcg caggtcgggc
      481 tggggctgtc gatcgcgggc ctggtggggc tggtgtgcgc cgtgcccatc ggctggctcg
      541 cggaccggtt cggcgacggg ccggtgctgg tggcgctgca gctgtggcgg gcggcggcgt
      601 tcctggtcta cccgctggtc gacgacttcc ggtggttcct cgtggtggcc tgtctggtcg
      661 gcgcggtcga gtgggccgcg atgccgatca tccagtcggt cgcgggggcc accagcgagg
      721 agggctcgat ggtgggggcc atggcggtgg tcgcggtggc gcgcaactcc gcctacgcgc
      781 tctccgccct ggccgccacc gccgtgatca cctgggcgtc cccgcgcgcc tatgtcgcgt
      841 tcgtgttcgt caacgcactg gggttcctcg tctcggggat cctgctgctg aggctgcggc
      901 tgccgcgccg ggcgacggac cacatgcccc gggagcgggg ggcgaagctg ctgccgttca
      961 aggacgtgcg gttcgtgctg ctgtccctca ccaacgggat cctgtacgcc cacatgccga
     1021 tcctgtccgt ggcctttccg ctgtggatcg tgacccggac cgacgcgccg cgcgcactcg
     1081 tcggggtggc gctgacgatc aacaccgtga tggcggtgct gttgcagatc cggctcagca
     1141 agggcgggga cgagctgcgc cgcgccggcc gcaagcagcg gctcgcgggg ctggcgctgg
     1201 ccgtcttctg cctgctcgtg gcgtgcaccc ggtcggtgga cggggtgacg gccacggcct
     1261 tgttgctgct ggccgcggtc gcgctgaccc tgggcgagct gtggcagtcg gcgggcggct
     1321 gggggatctc ctacgggctc gcccccgagg cgcagcgcac ctactacctg agtgtctatc
     1381 aactgggggc caccggagtg acggtggcgg gtccggcggt attggtgatg gccgtcgtgg
     1441 acgtgggtcc ggccggctgg atcgggctgg ccgccctgct ggcactcacg ggcctggtga
     1501 ccccggcgct cacccgcccg ccgcgccgga gggccgcggc cgccgccgct ccggccgact
     1561 gacccggggc tctcgggccg cggccgccgc cctcgtcagg gtgcgcgggt cggcgcctgc
     1621 gttccggtgc gtggcgtggt ccgctccgcg tccggcccgg ggccggtgag gtgcgtgacg
     1681 acggcgatga cggtggcggc tatggcgagc agggcaccga cgaggttggg cgaggcgtag
     1741 ccgaagcccg cgtcgatggc gaggccgccg agccaggccg cgagtgcgtt gccgacgttg
     1801 agtgcggcga cgttcgcggc cgaggcgagc gtgcgggccg tgggtgccac ctgcatgatg
     1861 cggtgctgca gggtggggat cgcggcggtg ccgcacagtc ccagcagcgt cagggtgatc
     1921 accgcgggtg tccggaagtg gatgctgtag gcgaggaccg cgagcagcac cgccagtgcg
     1981 gtcagggtgg tgtgcagcgt gccgacgggg aactttccgg cgaagtgccc gcccagcagg
     2041 ttgccgacgg acatcccgac gccgtagagc atgagaatca cggtgacggc ggccggcgcg
     2101 aacccggtca ccgtcacgag catcggctcg atgtaggtga acgaggcgaa aatggcggcg
     2161 gagaccagcg tggtgacgag gagcgtgacc cacacctgcc gccggcggaa cgcgcgcagt
     2221 tcggtgcgca gtcccccggc cgccggacgg ggccgggcgg gcagcaggac gaggatgctg
     2281 aggagcccga ggaatcccac gagcgccacg ctcaggaagg tggcccgcca gccgaagtgc
     2341 tggccgacga gcgtgcccag cggtacgccg aggatcgtcg agacggtcat gccgctgaag
     2401 atgagggaga tggccgtggc ccgccggtcc ggggcgacga ggtcggcggc ggtgaccgag
     2461 gcgacgccga agaaggcgcc gtgggccagc gacaccagca cgcgggcggc cagcagcagg
     2521 ccgtatccgg gggccactcc ggcgaggagg ttgcccccga cgaagacgga catcaggagc
     2581 accaggacgg cgcggcgggg taatcgggtg gtcagggcgg cgagcggaag tgcgccggcc
     2641 acgacgccga gggcgtagcc ggagacgaga tggccggcca cgggcacgga gacggacagg
     2701 tcggccgcca cgtccgagag caatcccatg atcacgaatt cggtcgtgcc gaccgcgaaa
     2761 gcgctgatgg ccagggcaag gatcgccagg ggcatacggc agatactcct caggcaggga
     2821 attgctgatg gtgtgtcagg aatgcggaca gcccctcacc gtcccggcgg ccccaccgag
     2881 gcccgttcga cgaactcgat cggcagcacc gtcctggccg tcgcggtgtc gtggcgcagg
     2941 aacctctcca tgcccaggcg gcccagctcc tgggagggca ggcgcaccgt cgtcagggcg
     3001 gggaccagca gggaggcgag gggcaggtcg tcgaatccga tgacggagag atcgccggga
     3061 atggacagtc ccaggccgtg cgcggcggag taggcgcagg cggccaggtt gtcgtcgtcg
     3121 cagatgatgc cggtcaccga ggtgtcgtcg cgcagtctgg cgaggatcag ctcccgtgtc
     3181 cgtgcgccgt cgaagggcac ggccaggctg cgtccccgta cccgggggtg tgccgcgatc
     3241 cggccgtcga aggccgcggt gcgctgggtg aacgtccagg cgtcgcgctg ggcgcggaca
     3301 tgcaggaggt gccggtgccc gaggcggacg aggtggtcca cggcggaccg catcccggcc
     3361 gccacctcca tggtgaccga gcagacgccg gcgtccgggt cgctgtccag ggccaccatg
     3421 gcgacgccgt cccggagccg gtcgatgctg tcggcggaga cggcacaggc gaggacgccg
     3481 tcgatggcct gccggggaaa ggggaacggt cctttgccgt cctcgccgtt gaggggatag
     3541 acgatcaccc cgatgccgcg ctcggcaccg gcgcgggccg ctccgctgtg cacatcggcg
     3601 aaatgcgggt tcgtcaggga ggggacgacc agcatcacgg tgccggttcg tcctaatcgc
     3661 agacttcgtg ccgagagatt gagtcgatag cccatgtcga ccgccgcatc cagaactttc
     3721 ttcgccattg tggccgagac ccgtccacgc cactttcccg ccatcaccag cgagacggtg
     3781 gcctgtgaca ccccaagtgt cctggcaagg tccttgcttg tcatctggtg cgcgccggcc
     3841 ggcgggttcc ctgccctgcc gagtccttct gacaacagtg ccccatctcc cgtgcgaatc
     3901 ccggacgttc agcttccgtt gcatcttgcg cgggacatca tacgtatgat ctggtggcgc
     3961 cacatcatac gtatgatgcc gctcgatccg agacatcggt cagcgacttc cggcgcatgg
     4021 agatctcaat gaaatcggcc gtcaccgtgt actgcggagc ctcactcggc gagcaccccg
     4081 gatacgcgga cgcagcgcgt caattagggc aggcactggc gcgggccgac atggatctgg
     4141 tctacggcgg tgcgtccacc ggcctgatgg ggtgcgtggc ggacgcggcg ctcctcggcg
     4201 gcagccgcgt caccggagtg atcccgcaga gcctcgtccg cttcgaggtc gcccacaccg
     4261 ccctcaccga gctgcgcgtc gtcgacacca tgcacgaacg caaggccctg atggctcagt
     4321 tgggcgatgc cttcgtggcg atgccgggcg gcttcggcac cgcggaggag ctgttcgagg
     4381 tcctgacgtg ggcccagctc ggcctgcacg ccaaaccgtg cgccctgctg aacaccaacg
     4441 gctactacac gccgctcctg aggttcctgg aacacgccgc cggcgaaggc ttcgtgcacc
     4501 ggcgctacct cgacaacgtc atcgtcgagg aggatccgca cgtcctgctc tcgcgcctct
     4561 cgggccaccg tgcgctgccg cacctcttcg aggaggtggc ggaggcatga ccacagcacg
     4621 ccgtccggca gcagcgggtg ccccctcccg gccgtccgat gccgcgtccc ccgcgcccgc
     4681 cctcgccgtg ttcgacctcg acgggaccct gctcccggag acgacgtcct gccgggagat
     4741 cgcccgggtg gtcggcaggc acgcggacat ccacgacctg gaagcggctt acggccgcgg
     4801 ggagatcgac agccgcgcct tcgcggtcag cgcgctgcgg tgctggagct cgggcggcga
     4861 gaccgtctac cgccgggcct tcgaggccgc gcgcttcctg gacggcatcc aggactgtct
     4921 gacctggctg cgcgcgcagg ggacgacgac cgtcctggtg acgatgtcgc accgggagtt
     4981 cgccgagtgc ttcgacggat tcgaccggat cttcgcgtcg gactaccccc gcgacatcct
     5041 cgaccccgag gacaagccgc tgatcgtcga ccggctgcgg gccggcctgg gcatcacccc
     5101 cgacgacgtc atcgccttcg gcgactcgat gtccgacctg ccgcttttcc gcaccctgcc
     5161 gcgcacggtc gccgtcaacg cctcccccgc cctcaccgaa ctggccgcgt accactaccg
     5221 gggcgacgac ctgcgcgagg cgctgcgcct ggtctgcccc gccgcggagt tcgtgtcatg
     5281 agtgcccggc accccaccgg ccgtaccgcg gccgcggcga ccgaaccgcc cccggccggg
     5341 accggcgccc tcaccgtgct gtgccggtcc ttcgccgacg acttcccggg cgggctggac
     5401 gccttccacg acgccctggg ccggcgaggg ctgaccaccg aggtgcacga acgggtcgac
     5461 gggcgcttcc ccgacgggga gttgtgcgtg gacctgcccg gggaccccac cggcgcccat
     5521 gtgctcgtgc accagtccct gaccggaccc gccgagcagg tcgaccggtc cgtgctggcg
     5581 ctgctggcgg tggcccgcgc ctaccgggag cacggggcgc gcaaggtgac cgccgtcgtg
     5641 ccgcacctcg cgtacgcgcg ccacgaccgg catgtccccg gtgaacgccg cccgatcatg
     5701 gccggcctgc tggcgcagct cgccgcgacc gcgggcatcg acacactcat caccctcgcc
     5761 tcgggcgcag aggaccggct cggaccactc agcgggcccc tgaacctggt gcaactcccc
     5821 tcggatcagg cgctgttggc gctggtgcgg ccctgggtcc tgcccggccg tacggtgctc
     5881 gtggccccgg acgcgggggc cgcccggcag gtccggcggc tcggcgaccg gctgcacctc
     5941 ccggtggtca ccgccaccaa gcggcgcacc ggtccggact ccgtcacggc cgccctcacg
     6001 tcgtcgccgc ccggccccgc cgaccgcgtc atcatcgtcg acgacctgat caccagtgcg
     6061 ggcacgatgc tggcggtggc ccggctggta cgggccgagt tcgaggggtg tcaggtgctc
     6121 tgcgcggcga cgcatctgcg ccccaccgcc accggcgaac agcgactggc cgccgcgctg
     6181 cgggacggga cgctgcaccg cgtgctcacc accgacgcgg cgggccaccg cccccgtatc
     6241 accggcctcg acgtcaccgc ggtcctgccg ttgatcgccg acgccgtcgc ctcccacgtg
     6301 ctccccgacc acgccccctt agcggaaagg cccactgcgc atgccggctc ccactgagct
     6361 gctcgaatcc gttcccccga ccgcgctgag cccggtcctg tcgatgtccg tggtctgcct
     6421 cgaccagacc aggctcggcg cacacatcga gaccctgcgg acgctgggga tcagccggct
     6481 gcacgtcgat ctcatcgacc cggcgttcgg acggaacgtg gggctgcccc tggagaccat
     6541 cagcgatctg gcggccacct gcggcctgcc gatcgacgtc cacgccatgc tgcaccgccc
     6601 cggtgacctg ctggagcagg ccgcgcagcg gggcgcggcc acggtctgcg tccaccagcg
     6661 gaccgtcacc cccgaggtac tggactgctt acggcgcatc gccgccggac ccaccgaggt
     6721 cggcctggtc gtcgacccgg gcgagggaat cgaccgggcg ctggtcgagc ggctgaaccc
     6781 cgcccagctg acggtgatga gcgtcgaacc gggcggtgcg gggcggccgt tccgcgacga
     6841 ggccctgctg accctggccg aggccgccga gctgcgcgag cgcgggacgg tgcagcgggt
     6901 ggaggccgac ggggcggtcg gaccggccac ggtcgcccgg ctggtgtccg ccggcgccgg
     6961 tcaactcgtc ctcggcagca cggtcttccc gcagcgcggc ccggcggaca accgcctgga
     7021 cgaactggcc ctggcgctct ccgccctctc ccccgcctga cctccggcgc ccctcccctc
     7081 cccgaccgac gaagaccaag gacggccctt catgacgccc acccatccca tcaccatcgg
     7141 cgacgtccgc cgcgagctgc cgatcgtccg ggtggcggac gacgcccgga tcgccttcct
     7201 caagctgtac ggcgacgtgg aactcaccgt cgcctgcgcc cgcgcgctgg ccgagcggat
     7261 gccgacggac atcgatgtca tcgtcggccc ggagaccggg ggcatcctgc tcgcccacga
     7321 gctcgccgag cactccgggc gtccctacgc gatcgcccgc aagaagctgc gcccgaacat
     7381 ggtcaagccg ctccgtgtcc cggtgcagag catcggaaca ccgggcaggc aggaactctt
     7441 cctcggcgac gacgacgtgg cgctcgtcga gggccgccgc gtcgccctcg tcgacgaggt
     7501 cgtcagcagc ggcggcaccc tgaccgcgct ccatgaactc gtcgccacgg ccggcggcac
     7561 cgtgcggcag gtgctggccg tggccaccga gggcgagcgc aggccggagg tggagtcgct
     7621 gctgcacctg cccgtcttcc cgggctagtg cggcgacgcc cgtccccgta cacgtacctc
     7681 ctgaccaccc gcacccgaca ggacgacgta ggagttgccc gatgacaccc accatccatg
     7741 ccagcgaggt cgccgacatg ggcctcgccg accatggtga aggactgtgc gactggtcgg
     7801 cccagtcgat gcccatcctg gcgcggttac gtgagcgcta cgccgcggag aagcccttcg
     7861 cgggccggcg catcgcgatc gccgtgcaca tcacgaccga gaccgccaat ctcgccctga
     7921 ccctgcaggc cggcggcgcc gaggtcttcc tgtgcgcctc caacgtacgg acgacgaacg
     7981 acgcggtggc cgcctacgcg gcccggcagg gggtgcacgt ccacggcatc cagggcgagg
     8041 accgcgagac ctacgccgca cactgccacc gcgtcctgga cgcccgcccg cacctggtca
     8101 tcgacgacgg cgcggatctg accggcctgc tgcacggcgc gcgcaccgac gccgcgtccg
     8161 acgtcgtcgc gggcctggag gagaccacgg cgggcatcca gcgcatccgc agcctggagg
     8221 ccgacgggct gctgcgctac cccgtcatcg cggtcaacga ggcgcgtacc aagcacctct
     8281 tcgacaaccg ctacggcacc ggccagagca ccatggacgc cgtcctgcgc ctgacgaaca
     8341 cgctggtggc cggctcacgg gtggtcgtgg ccggttacgg gatgtgcggc aagggcgtgg
     8401 cggcacgggc ccgcgggatg ggcgccgatg tcctggtgac cgaggtggac cacgtccggg
     8461 ccctggaggc cgtgatggac ggataccggg tcatggagat ggaccgtgcc gcggagctcg
     8521 gtgacctctt catcacggtc accagcagca agaacgtcct gcgggccgag cacttcgcgc
     8581 tgatgcccga cggtgccatc gtgtgcaact ccgggcactt cgacgtcgag atcgatgtgc
     8641 cggcgctgcg cgccgcggcc cgcaagcaca cccgcccccg ccccggcgtc gaccagtaca
     8701 ccctcgcgaa cggccggcgc atcaccctcc tcgccggcgg cgaagtggtg aacctcgccg
     8761 ccgccgaggg caacccggcc acgttgatgg acatgtcctt caccaaccag gtcctgggct
     8821 gcgagtacct cctccggaac gccgcccaca tggaccgccg ggtgcacgcc ctgcccgcgg
     8881 acatcgacga ccacgtggcc gacctcaaac tccggacact gggcgtcggc atcgacaccc
     8941 tgagcgagga acagatcgcc tacctgcgct cctgggacca gggcagcgcc tgacggcccc
     9001 ctcccggggc ggcaccggcc gcggcggcgg gctcacccct gcccccgtgg ccggtgcggt
     9061 gggaagggca accggtcgct tcgtccgttc aagcttcctg cgccgcgacc ccgctcgtcc
     9121 gcgtcacagc aacgcacccc ctcgcgcacc cgagtcgcgc ccacgggccg atgacgtacg
     9181 gcatgatcgg aagcgcacca agtcggtgcg agggatgc
//
