BGC0002634 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002634 (Streptomyces parvus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	67,619	vicenistatin	PKS+NRPS:Type I+other:other	100%

BGC0002634 - Region 1 - T1PKS

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Location: 1 - 67,619 nt. (total: 67,619 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 67,620
Label		BGC0002634

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002634	1.00	Polyketide, NRP, Other	vicenistatin	Streptomyces parvus
BGC0000167	0.55	Polyketide	vicenistatin	Streptomyces halstedii
BGC0001163	0.32	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001164	0.32	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000122	0.31	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000278	0.31	Polyketide	urdamycin	Streptomyces fradiae
BGC0001817	0.31	Other	vancosamine	Streptomyces sp. WAC2288
BGC0002729	0.31	Polyketide	sordarial	Neurospora crassa OR74A
BGC0001749	0.30	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0001273	0.30	Polyketide	asperlactone	Aspergillus ochraceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002634	1.00	Polyketide, NRP, Other	vicenistatin	Streptomyces parvus
BGC0000167	0.81	Polyketide	vicenistatin	Streptomyces halstedii
BGC0001163	0.66	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001164	0.65	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000122	0.65	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000278	0.64	Polyketide	urdamycin	Streptomyces fradiae
BGC0001817	0.64	Other	vancosamine	Streptomyces sp. WAC2288
BGC0002729	0.64	Polyketide	sordarial	Neurospora crassa OR74A
BGC0001749	0.64	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0001273	0.63	Polyketide	asperlactone	Aspergillus ochraceus

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 67619:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (redmal - ccmal - Me-ccmal) + (Me-redmal) + (ccmal - Me-ohmal) + (ccmal - ccmal)
Non-colinear ordering:: UHH90025.1 + UHH90010.1 + UHH90011.1 + UHH90012.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

UHH90010.1

PKS_AT (589..896): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 198.2
Ethylmalonyl-CoA: 174.3
Methoxymalonyl-CoA: 142.0
2-Methylbutyryl-CoA: 118.2
trans-1,2-CPDA: 105.1
Malonyl-CoA: 98.0
Propionyl-CoA: 93.6
CHC-CoA: 91.1
Benzoyl-CoA: 55.3
Isobutyryl-CoA: 53.8
Acetyl-CoA: 53.0
inactive: 40.1
3-Methylbutyryl-CoA: 35.0
fatty_acid: 32.9

UHH90011.1

PKS_AT (571..873): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%

minowa: inactive

Prediction, score:

inactive: 91.5
Malonyl-CoA: 61.7
Methoxymalonyl-CoA: 26.4
Propionyl-CoA: 11.5
Methylmalonyl-CoA: 6.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2324..2635): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 194.6
Ethylmalonyl-CoA: 167.9
Methoxymalonyl-CoA: 139.8
2-Methylbutyryl-CoA: 109.0
trans-1,2-CPDA: 103.6
Propionyl-CoA: 93.1
Malonyl-CoA: 91.1
CHC-CoA: 87.3
Benzoyl-CoA: 51.0
Acetyl-CoA: 50.5
Isobutyryl-CoA: 49.0
inactive: 33.0
fatty_acid: 32.0
3-Methylbutyryl-CoA: 31.3

UHH90012.1

PKS_AT (566..868): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 191.3
inactive: 109.4
Methoxymalonyl-CoA: 55.4
Methylmalonyl-CoA: 49.1
Propionyl-CoA: 23.7
Acetyl-CoA: 18.2
Isobutyryl-CoA: 15.1
Ethylmalonyl-CoA: 14.9
CHC-CoA: 14.1
Benzoyl-CoA: 11.8
2-Methylbutyryl-CoA: 9.2
fatty_acid: 8.5
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2325..2627): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.7
inactive: 109.1
Methoxymalonyl-CoA: 56.8
Methylmalonyl-CoA: 49.9
Propionyl-CoA: 25.2
Acetyl-CoA: 22.7
Isobutyryl-CoA: 17.2
Ethylmalonyl-CoA: 15.4
CHC-CoA: 14.6
Benzoyl-CoA: 10.6
fatty_acid: 8.5
2-Methylbutyryl-CoA: 8.4
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

UHH90020.1

PKS_AT (18..295): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

UHH90022.1

AMP-binding (15..421): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DCFFLALVTK
Nearest Stachelhaus code(s):: bMe-Asp DCFFFALITK (79% 8Å match); Ala DCFFFALITK (76% 8Å match)
Stachelhaus code match:: 80% (moderate)

UHH90023.1

AMP-binding (26..424): X

nrpys: Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DFYPTSMRIK
Nearest Stachelhaus code(s):: 3S-Abu DYYPTTQRIK (68% 8Å match); Asp DYYPTTMRVK (65% 8Å match)
Stachelhaus code match:: 70% (weak)

UHH90025.1

PKS_AT (667..969): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.6
inactive: 107.6
Methoxymalonyl-CoA: 52.5
Methylmalonyl-CoA: 44.8
Propionyl-CoA: 19.5
Isobutyryl-CoA: 18.3
CHC-CoA: 15.9
Acetyl-CoA: 15.9
Benzoyl-CoA: 15.8
Ethylmalonyl-CoA: 12.0
fatty_acid: 10.5
2-Methylbutyryl-CoA: 10.2
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2759..3061): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.3
inactive: 109.4
Methoxymalonyl-CoA: 55.0
Methylmalonyl-CoA: 48.4
Propionyl-CoA: 22.6
Isobutyryl-CoA: 19.2
Acetyl-CoA: 18.0
CHC-CoA: 16.2
Ethylmalonyl-CoA: 14.6
Benzoyl-CoA: 12.7
fatty_acid: 9.0
2-Methylbutyryl-CoA: 8.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4536..4847): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.4
Ethylmalonyl-CoA: 168.3
Methoxymalonyl-CoA: 141.4
2-Methylbutyryl-CoA: 111.2
trans-1,2-CPDA: 104.7
Malonyl-CoA: 93.3
Propionyl-CoA: 92.7
CHC-CoA: 87.1
Benzoyl-CoA: 53.4
Isobutyryl-CoA: 48.3
Acetyl-CoA: 47.8
inactive: 35.8
fatty_acid: 34.3
3-Methylbutyryl-CoA: 29.4