LOCUS       BGC0002635              6932 bp    DNA     linear   BCT 21-AUG-2021
DEFINITION  Actinokineospora diospyrosa strain NBRC 15665 DisA, DisB, DisC,
            DisD, DisT, and DisU genes, complete cds.
ACCESSION   BGC0002635
VERSION     BGC0002635
KEYWORDS    .
SOURCE      Actinokineospora diospyrosa
  ORGANISM  Actinokineospora diospyrosa
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Actinokineospora.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 18:07:18
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..174
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /note="Precursor peptide"
                     /product="DisA"
                     /protein_id="QYZ85378.1"
                     /sec_met_domain="TIGR03731 (E-value: 2.2e-14, bitscore:
                     42.0, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTIEMTAPAGAELDLFDLDLEVSVEQMSLTPAITSISLCTPGCT
                     SAGGGSNCSFCC"
     CDS_motif       1..99
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence:
                     MPTIEMTAPAGAELDLFDLDLEVSVEQMSLTPA"
                     /locus_tag="QYZ85378.1_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       100..174
                     /prepeptide="core"
                     /locus_tag="QYZ85378.1_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="9.20"
                     /molecular_weight="2079.4"
                     /monoisotopic_mass="2077.9"
                     /core_sequence="ITSISLCTPGCTSAGGGSNCSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPTIEMTAPAGAELDLFDLDLEVSVEQMSLTPA"
                     /leader_location="[0:99](+)"
                     /alternative_weights="2097.4"
                     /alternative_weights="2115.5"
                     /alternative_weights="2133.5"
     source          1..6932
                     /culture_collection="NBRC:15665"
                     /db_xref="taxon:103728"
                     /isolation_source="soil"
                     /mol_type="genomic DNA"
                     /organism="Actinokineospora diospyrosa"
                     /strain="NBRC 15665"
                     /type_material="type strain of Actinokineospora diospyrosa"
     protocluster    1..6932
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[247:4614]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      248..4614
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..6932
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..6932
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002635"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..6932
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03604))"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             248..3304
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     849.2; E-value: 6.4e-257)"
                     /gene_kind="biosynthetic"
                     /note="lantibiotic dehydratase"
                     /product="DisB"
                     /protein_id="QYZ85379.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.2e-178,
                     bitscore: 580.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.4e-17,
                     bitscore: 51.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.4e-40, bitscore:
                     126.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDPLLRAWPVFLVRAPLVPEAGGPGVADQDDHLGVLRAAVADPVL
                     TEAITLASPTLGAVLARVAAGGAAGLKAKQVRRAALSVLRYDIRTRTRPTPFGLFAGVS
                     AGGFGAPQVLRGSAHRHRTHVDMSWLARVVHRAEADPGVLAGLRVRAHQALVHRGDRVV
                     LETPSGLGAVPGQTTRSFVSARRSPVVAAALALAATPIAVTDLVAVLAERFAGGAAAPA
                     AKLVRSLVEQELLITDLRPPLDGGDPLRHVLSRLPEGDLRTRLTELDRLREKYDALAPG
                     EGTAALVELVDAAREVEPFDTPLHVDTRVDLRVTAAEAVREEVERAATVLWRLSPPRLG
                     MRPLRGFHGRFLERYGADRLVPVLELLDTTRSLGAPPGYEWPPSEAVAETAAEPSSTRR
                     DRAVSRLVLDASRTGSREAVLTDEVLAELAHDDADPADLPNSCELYVHVVERADGDFRV
                     VLSPSPGSHHAGATTARFHDLLPHWPHEPHPVHVEGAVLADLAFTPRSGRAANLAHTPP
                     TTGRRIAVGLPDAPGVEEIPLAEVAVGATLERLYAVHVPTGRELVPVLPNMVSPAVQAP
                     NAIRLLFELGMEGQRLWEPWNWGPMANAPFLPRVRYGRSILAPATWRLDELRGHDDEAD
                     FDAGLARWREQWAVPDRVLLVSTDQRLLVHLDNRWHRRLLRDELRRDPDLIAQEVAGGD
                     ETVGDGHTRELVVALVPRPHRARPPHVAHVVDRPARSPLAGDWLYLLVHGSRQGQDDLL
                     RDEVPALVRLAADTGADRWFFIRYTDADGHHLRLRFHGDPALLWSRLLPAASALLARWQ
                     EDGLVGAHRVQPYEPELERYGGIDALEAAERVFCEDSAAAIALLRLAKSSPFSLDALGA
                     ISVASLAHAFGHPPPGTPWITPTGEAAESWLTITGTRRDLPQAYRADPARWQGWIDPAA
                     GWPGLGADGAPVLAALAARDAAVRDYARLVADLIAEGRSAAPLARVVGSLLHMTCNRLL
                     GGSSERERAVLGIARGAVQDNGNRRRHRA"
     CDS             3301..4614
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     346.8; E-value: 2.6e-105)"
                     /gene_kind="biosynthetic"
                     /note="lantibiotic cyclase"
                     /product="DisC"
                     /protein_id="QYZ85380.1"
                     /sec_met_domain="LANC_like (E-value: 1.4e-51, bitscore:
                     163.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGAAQRLSTAEAVALVAHRLADPDAVAAIADRPDNVEPIYGASQ
                     WGPLTLANGLPGIALLYAELAATDDRWSAVAHRQVSRAAELMSSQAANGLYAGPAALLA
                     AVLRLQPHYATLRRKLIAWVADDQRTRLEACAARRDLGVSWAHYDVVNGLSGTARLLLD
                     AGPSVHGVVEDTLRYLVTLCEPITVDGVRVPGWWVPAELQPVARDAEQYPRGDFNLGLA
                     HGIAGPLALFAAALDRGHEVPRQRDAMRRIATWLLDRRKHDTAGVYWPCRLSWDEETHP
                     GPEPVFTRAAWCYGAPGVVSAVHQTGLALGESQWCAAAVEGLRTTVDRPENEWNLDGPT
                     VCHGYAGLLQIVRRVGTTSGDPALLAAIPGLVDRTLSYATPDAPFVFPHLVPDSPLGRH
                     AGTGYRRLNVAGMLEGAAGVACALLPSAGAWDTALMLA"
     CDS             4625..5260
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /note="flavoprotein decarboxylase"
                     /product="DisD"
                     /protein_id="QYZ85381.1"
                     /sec_met_domain="Flavoprotein (E-value: 1.3e-24, bitscore:
                     75.3, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTPPAQPTHPNPPPTHSSPPAQPAHANPPTHPSPLTPPRKLLLG
                     VSGSVAALGLPGYLYAFRAAGVSEIIAVVTTSALQFLPVTGLAALCDRVCTDGDSSLGH
                     VALARWAEHTLVLPATAHLLGCLANGLAPSLLATTLLAVDGPVTLAPAMNAAMWRRPAV
                     RRNVATLRADGHQVIDPVPGAVYEVASRAVVAGIAVPPPAVVLERISA"
     CDS             5257..6171
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 214.4; E-value:
                     3e-65)"
                     /gene_kind="transport"
                     /note="putative ABC transporter"
                     /product="DisT"
                     /protein_id="QYZ85382.1"
                     /transl_table=11
                     /translation="MNAAFDVRDIVVRYGRRTAVDGVSLSAAPGTIVALLGPNGAGKST
                     LLRAVSTAVPPDEGRIEVFGHDVARDPVAARARIGVVFQERTLDPDLSVWRNLWFHARL
                     FGLSRPRARARIDEVLERFGLADRREDTVAQLSGGLARRLEIARALVHRPGLVVLDEPT
                     TGLDPDARRDVWADLRRLRDEHRVSVLYATHYLGEAELADHIAIIHNGVVVRRGSPAEL
                     KSGLAASALRLSTEDDASAARQLSSAGFDARVSVEGVSVRCARPESHVAEVVRAVSVAV
                     REVAVVAPSLDDVYFATTEGSST"
     misc_feature    5932..5934
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             6168..6932
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065:ABC-2 type
                     transporter (Score: 119.4; E-value: 2.4e-36)"
                     /gene_kind="transport"
                     /note="ATP-binding protein"
                     /product="DisU"
                     /protein_id="QYZ85383.1"
                     /transl_table=11
                     /translation="MSGTAIADVGRALGVVAARDLHRQARHPGVLVAQGVQVLFFLLVY
                     AIGFDGMIGSVDGLPFSAYVYPGIVAIQVVTLGVSSGLTYAFDREYGMLREMLVAPVPR
                     LCLPLGKVVATAVLAGGQAAVMLAFAPLLGLPLSLVGYLGGVLAFAVVCVVFGLAGVLL
                     ATLVPQVQTLQSVVQMAMYPLLFLSGSVFRPDAGPGWLSAVMRINPMTYATDAIRHLLI
                     PGHGAFPLWLDLVVLAGLTAVLATVLRWKVGR"
ORIGIN
        1 atgccaacga tcgagatgac cgcccctgcc ggggccgagc tggacctgtt cgacctggac
       61 ctggaggtca gcgtcgagca gatgtcgctg acgcccgcca tcaccagcat ctcgctgtgc
      121 acccccgggt gcaccagcgc tggcggcggc agcaactgca gcttctgctg ctaaacggtg
      181 cgtcgcgccg ggtcgggggg acgcccccgg cccggcgcca cccgactcga cccctggggg
      241 ctgaccgatg gacccgctgt tgcgagcctg gccggtgttc ctggtccgcg ccccgctggt
      301 gcccgaggcg ggcggacccg gtgtcgccga ccaggacgac cacctcggcg tgctgcgcgc
      361 cgccgtggcc gacccggtgc tgaccgaggc gatcaccctg gccagcccga ccctgggcgc
      421 ggtgctcgcc agggtcgccg cgggcggggc ggccgggctc aaggccaagc aggtgcgccg
      481 ggccgcgctc tcggtgctgc gctacgacat ccggacccgg acccgcccga ccccgttcgg
      541 cctgttcgcc ggggtgagcg cgggcggctt cggcgcgccg caggtgctgc gcggctcggc
      601 gcaccggcac cgcacgcacg tcgacatgag ctggctggcc cgggtcgtgc accgcgccga
      661 ggccgacccc ggggtgctgg ccgggctgcg cgtgcgcgcc caccaggccc tggtccaccg
      721 cggcgaccgg gtggtgctgg agaccccgtc cgggctgggc gcggtgcccg ggcagacgac
      781 ccgctcgttc gtgtccgcgc gccgctcccc ggtcgtggcc gccgcgctgg cgctggccgc
      841 caccccgatc gcggtcaccg acctggtggc ggtcctcgcc gagcggttcg ccggtggcgc
      901 ggccgccccg gcggcgaagc tggtgcgctc gctggtcgag caggagttgc tgatcaccga
      961 cctgcgcccg ccgctcgacg gcggcgaccc gctgcgccac gtcctgtccc ggctgcccga
     1021 gggcgacctg cgcacccggc tgaccgagct ggaccggttg cgggagaagt acgacgccct
     1081 cgcccccggt gagggaaccg cggcgctggt cgagctggtc gacgcggcgc gggaggtcga
     1141 gccgttcgac acgccgctgc acgtcgacac ccgggtggac ctgcgggtca ccgcggcgga
     1201 ggcggtgcgc gaggaggtcg agcgggccgc gaccgtgctg tggcggctct cgccaccccg
     1261 gttgggcatg cggccgctgc gcgggttcca cggccgtttc ctggagcgct acggcgccga
     1321 ccggctggtc ccggtcctgg aactgctgga caccacccgg tccctcggcg ccccgcccgg
     1381 ctacgagtgg cccccgagcg aggcggtggc cgagaccgcg gccgagccgt cgagcacccg
     1441 gcgcgatcgg gcggtcagcc ggttggtgct ggacgcgtcg cgcaccgggt cgcgcgaggc
     1501 cgtgctgacc gacgaggtgc tcgccgaact cgcccacgac gacgccgatc ccgcggatct
     1561 gcccaactcg tgcgagctct acgtgcacgt ggtcgagcgg gccgatggcg acttccgggt
     1621 cgtgctctcg cccagtcccg ggtcccacca cgccggggcg accacggccc ggttccacga
     1681 cctgctcccg cactggccgc acgagccgca cccggtgcac gtcgaggggg cggttctcgc
     1741 ggacttggcc ttcacgccgc ggtccggtcg cgcggccaac ctcgcgcaca cgccgccgac
     1801 gaccgggcgg cgcatcgcgg tcgggctgcc ggacgcccct ggcgtggagg agatcccgct
     1861 ggccgaggtc gccgtcggcg cgacgctgga gcgcctctac gcggtgcacg tgccgaccgg
     1921 ccgcgagctc gtccccgtgc tgccgaacat ggtcagcccc gccgtccagg cgcccaacgc
     1981 catccgcctg ctgttcgagc tcgggatgga ggggcagcgg ctgtgggagc cgtggaactg
     2041 ggggccgatg gcgaacgcgc ccttcctgcc ccgggtccgc tacggccggt ccatcctcgc
     2101 gcccgccacc tggcggctgg acgagctgcg cggccacgac gacgaagccg acttcgacgc
     2161 gggcctggcg cggtggcgcg agcagtgggc cgtgcccgac cgggtgctgc tcgtcagcac
     2221 cgaccagcgg ctgctggtcc acctggacaa ccggtggcac cggcggttgc tgcgcgacga
     2281 actgcgccgc gaccccgacc tcatcgccca ggaggtcgcc ggtggcgacg agaccgtcgg
     2341 cgacggccac acccgcgagc tcgtcgtcgc cctggtcccg cgaccgcacc gggcacggcc
     2401 gccgcacgtc gcgcacgtcg tcgaccgccc cgcgcgctca ccgctggcgg gggactggct
     2461 gtacctgctg gtccacggtt cccggcaggg gcaggacgac ctgctgcgcg acgaggtgcc
     2521 cgcgctcgtg cgactcgccg ccgacacggg cgccgaccgg tggttcttca tccgctacac
     2581 cgacgccgac ggccaccacc tgcggctgcg gttccacggc gaccccgccc tgctgtggtc
     2641 gcgtctgctg cccgcggcga gcgctctgct ggcgcggtgg caggaagacg ggctcgtggg
     2701 cgcgcaccgg gtgcagccgt atgagccgga actggagcgc tacgggggta tcgacgcgct
     2761 tgaggcggcg gaacgcgtct tctgcgagga cagcgccgcg gccatcgcgt tgctgcggtt
     2821 ggccaagagc tccccgttct cgttggacgc cttgggggcg atctcggtcg cgtcgttggc
     2881 gcacgccttc gggcacccgc cgccggggac gccgtggatc acccccaccg gggaggcggc
     2941 cgagtcctgg ctgacgatca ccggcacccg gcgcgacctg ccgcaggcct accgcgccga
     3001 cccggcccgt tggcaggggt ggatcgaccc ggcggccggg tggccggggc tgggcgccga
     3061 tggcgcgccc gtgctcgccg cgctcgcggc tcgggacgcg gcggtgcgcg actacgcacg
     3121 gctggtcgcc gatctgatcg ccgaggggcg cagcgccgca ccgttggcgc gcgtggtcgg
     3181 cagcctgctg cacatgacgt gcaaccggct cctcggcggc tcgtccgagc gcgagcgggc
     3241 cgtgctgggc atcgccaggg gagcggtgca ggacaacggg aacaggcgga ggcaccgagc
     3301 atgaccggcg cagcgcaacg actgtccaca gcggaggcgg tggcgctggt ggcgcaccgg
     3361 ctggccgacc cggacgcggt cgccgcgatc gccgaccgcc cggacaacgt ggagccgatc
     3421 tacggcgcgt cccagtgggg gccgctgacc ctggccaacg gcctgcccgg catcgcgttg
     3481 ctgtacgccg aactggccgc caccgacgac cgctggtccg cggtcgcgca ccggcaggtc
     3541 agccgggccg ccgagctgat gtcgtcgcag gccgccaacg ggctctacgc cggacccgcc
     3601 gcgttgctgg ccgctgtcct ccgactgcaa ccgcactacg cgactttgcg ccgcaagctg
     3661 atcgcgtggg tggccgacga ccagcggacc cgactggagg cgtgcgcggc gcgccgggac
     3721 ctgggcgtgt cctgggcgca ctatgacgtc gtcaacgggc tttccggtac tgcccggttg
     3781 ttgctcgacg ccggtccttc ggtgcatggg gtcgtcgagg ataccttgcg gtacctggta
     3841 accctgtgcg aaccgatcac tgtggacggt gtgcgcgtgc ccgggtggtg ggtgcccgcc
     3901 gagctgcagc cggtcgcgcg ggacgcggag cagtacccgc gcggggactt caacctcggc
     3961 ctggcacacg gcatcgcggg ccccctggca ctgttcgccg ccgcgctcga ccgcggccac
     4021 gaggtaccac gccagcgcga cgccatgcgc cggatcgcca cctggctgct cgaccgacgc
     4081 aagcacgaca cggctggcgt ctactggccg tgcaggctct cctgggacga ggagacacac
     4141 ccgggacctg agccggtctt cacccgcgca gcctggtgct acggcgcccc tggtgttgtc
     4201 tccgcagtgc accaaacggg cctcgccctc ggcgaatcgc agtggtgcgc cgccgccgtc
     4261 gagggcctac ggaccactgt ggaccgtcca gagaacgagt ggaacctcga cggcccaacg
     4321 gtatgccacg gctacgcggg cctactccaa atcgtgcgcc gagtcggcac aacctccggc
     4381 gaccccgcac tactcgccgc catccccggt ctggtcgacc gcaccctcag ctacgccacc
     4441 cccgacgcac cgttcgtgtt cccccacctc gtgccggact cacccctggg cagacacgcc
     4501 ggcaccggct accgccgcct caacgtcgcc ggaatgctcg aaggcgccgc cggggtcgcc
     4561 tgtgccctgc tgccctcagc cggggcctgg gacaccgccc tgatgctggc ctgaggagaa
     4621 caccatgccc accccacccg cccagcccac ccaccccaac ccgccaccca cccactccag
     4681 cccacccgcc cagcccgcgc acgcaaaccc gcccacccat ccaagtccgc tcaccccgcc
     4741 ccgcaagctc ctgctgggcg tcagcgggtc ggttgctgcg cttgggttgc ccggttacct
     4801 gtatgcgttc cgggccgcgg gcgtcagcga gatcatcgct gtggtcacca cctccgccct
     4861 gcagttcttg ccggtgactg ggttggcggc gttgtgcgac cgggtttgca ccgacggcga
     4921 ctcgtcgctc ggccatgttg cgctggctcg gtgggctgag cacacgctgg tgctcccggc
     4981 caccgcgcac ctgctcggct gcctggccaa cgggttggcc cccagcctgc tggcgaccac
     5041 cctgctcgcg gtggacggcc cggtcaccct cgcccccgcg atgaacgcgg cgatgtggcg
     5101 gcggcccgcc gtgcggcgca acgtcgctac cctgcgcgcc gatggccacc aggtcatcga
     5161 cccggttccg ggcgcggtct acgaggtcgc cagccgcgcc gtggtggcgg gcatagcggt
     5221 gccgccgccc gcggttgtgc ttgagcggat cagcgcgtga acgccgcgtt tgacgtgcgt
     5281 gacatcgtgg tccgctacgg gcggcgcacc gcggttgacg gggtgtcgct gagcgccgcg
     5341 cccggcacga tcgtcgccct gctgggcccg aacggggcgg gcaagtcgac gctgctgcgc
     5401 gcggtgtcca ccgccgtgcc gcccgacgag gggcggatcg aggtgttcgg ccacgacgtc
     5461 gcccgcgacc cggtcgccgc gcgcgcccgg atcggggtgg tgttccagga gcgcaccctc
     5521 gaccccgacc tgtcggtgtg gcgcaacctg tggttccacg cccggctgtt cggcctgagc
     5581 agaccgcgcg cgcgggccag gatcgacgag gtgctcgagc ggttcgggct cgccgaccgg
     5641 cgcgaggaca ccgtcgcgca gttgtccggc gggctcgcca ggcgcctgga gatcgccagg
     5701 gcgctggtgc accggccggg cctggtcgtg ctggacgagc cgaccaccgg cctggacccc
     5761 gacgcgcgcc gcgacgtctg ggccgacctg cggcgcctgc gcgacgagca ccgggtcagc
     5821 gtcctctacg cgacgcacta cctcggcgag gcggagctgg ccgaccacat cgcgatcatc
     5881 cacaatggag tcgtcgtgcg ccgaggatcg cctgcagagc tcaagagcgg gttagctgcc
     5941 tcggcccttc gactatccac tgaagacgat gcgagcgcgg cgcgacagct gtcctcggcc
     6001 gggttcgacg cgcgggtgtc ggtcgagggc gtgtcggtgc gctgcgcccg accggagagc
     6061 cacgtcgccg aggtcgtgcg cgcggtgtct gtcgcggttc gcgaggtggc cgtcgtggcg
     6121 ccctcgctcg acgacgtcta cttcgccacc accgagggga gttcgacgtg agcggcaccg
     6181 ccatcgccga cgtgggccgg gcactgggcg tggtcgccgc ccgcgacctg caccggcagg
     6241 cccgccaccc cggagtgctc gtcgcgcagg gcgtgcaggt gctgttcttc ctgctggtct
     6301 acgcgatcgg gttcgacggg atgatcggct cggtcgacgg gctgccgttc agcgcgtacg
     6361 tctaccccgg catcgtcgcc atccaggtgg tgaccctcgg ggtgagttcc gggctgacct
     6421 acgccttcga ccgcgagtac gggatgctgc gggagatgct cgtggcgccg gttccccggc
     6481 tgtgcctgcc gttgggcaag gtcgtggcga cggcggtcct ggccggtggg caggccgcgg
     6541 tgatgctggc cttcgccccg ttgctcgggt tgccgctgag cctcgtcggt tacctcggcg
     6601 gggtgctggc gttcgcggtc gtctgcgtgg tgttcggctt ggcgggtgtg ctcctggcga
     6661 cgctcgtccc ccaggtgcag acgctgcagt cggtggtgca gatggcgatg tacccgctgt
     6721 tgttcctctc cggttcggtg ttccgcccgg acgccgggcc ggggtggctg tccgcggtca
     6781 tgcgtatcaa cccgatgacc tacgcgacgg acgcgatccg gcacctgctg atccccgggc
     6841 acggcgcgtt cccgctgtgg ttggacctcg tggtgctcgc cgggctcacc gcggtgctgg
     6901 ccaccgtgct gcgctggaag gtgggccggt ga
//
