BGC0002637 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002637 (Streptomyces sp. WAC 06783)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	75,560	rimomycin A/rimomycin B/rimomycin C	NRPS:Type I	100%

BGC0002637 - Region 1 - NRPS

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Location: 1 - 75,560 nt. (total: 75,560 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 75,561
Label		BGC0002637

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002637	1.00	NRP	rimomycin A, rimomycin B, rimomycin C	Streptomyces sp. WAC 06783
BGC0000326	0.48	NRP	isocomplestatin	Streptomyces lavendulae
BGC0001133	0.37	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002341	0.35	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002631	0.32	RiPP	myxarylin	Pyxidicoccus fallax
BGC0002608	0.32	NRP, Polyketide	ochratoxin A	Aspergillus steynii
BGC0001925	0.32	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0000343	0.32	NRP	enterobactin	Pseudomonas sp. J465
BGC0000351	0.31	NRP	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0000426	0.30	NRP	sevadicin	Paenibacillus larvae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002637	1.00	NRP	rimomycin A, rimomycin B, rimomycin C	Streptomyces sp. WAC 06783
BGC0000326	0.77	NRP	isocomplestatin	Streptomyces lavendulae
BGC0001133	0.69	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002341	0.68	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0002608	0.66	NRP, Polyketide	ochratoxin A	Aspergillus steynii
BGC0001925	0.65	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0000343	0.65	NRP	enterobactin	Pseudomonas sp. J465
BGC0000351	0.65	NRP	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0000426	0.63	NRP	sevadicin	Paenibacillus larvae

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 75560:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Hpg - D-Trp) + (D-Hpg) + (D-Hpg - D-Hpg - D-NMe-Tyr) + (Hpg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

DMH18_08080

Search NORINE for peptide: strict or relaxed

AMP-binding (466..862): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFHLGLLCK
Nearest Stachelhaus code(s):: Hpg DAFHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1526..1909): X

nrpys: Phe, Trp, Ph-Gly, Tyr, bOH-Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ---VLVAGPK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

DMH18_08085

Search NORINE for peptide: strict or relaxed

AMP-binding (463..853): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DVFHLGLLCK
Nearest Stachelhaus code(s):: Hpg DVFHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1989..2389): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DAYHLGLLCK
Nearest Stachelhaus code(s):: Hpg DAYHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3528..3926): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DASTTAAVCK
Nearest Stachelhaus code(s):: Tyr DASTTAAVCK (100% 8Å match); Phe or Tyr DASTTAAVCK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

DMH18_08090

Search NORINE for peptide: strict or relaxed

AMP-binding (468..867): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFHLGLLSK
Nearest Stachelhaus code(s):: Hpg DAFHLGLLSK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

DMH18_08095

Search NORINE for peptide: strict or relaxed

AMP-binding (467..873): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DAYHLGMLCK
Nearest Stachelhaus code(s):: Hpg DAYHLGMLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2034..2441): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: trp (Trp)

Stachelhaus prediction details:

Stachelhaus sequence:: DVGVVGEVTK
Nearest Stachelhaus code(s):: Trp DVGVVGEVTK (100% 8Å match)
Stachelhaus code match:: 100% (strong)