BGC0002637: rimomycin A biosynthetic gene cluster from Streptomyces sp. WAC 06783
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Location: 67,545 - 143,104 nt. (total: 75,560 nt).
This entry is originally from NCBI GenBank QHJP01000004.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002637
Short description rimomycin A biosynthetic gene cluster from Streptomyces sp. WAC 06783
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
QHJP01000004.1
67545 - 143104
via Heterologous expression, Gene expression correlated with compound production
Compounds
  • rimomycin A
  • rimomycin B
  • rimomycin C
Species Streptomyces sp. WAC 06783 [taxonomy]
References
Chemical products information
rimomycin A Evidence:
(no structure information available)
rimomycin B Evidence:
(no structure information available)
rimomycin C Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • DMH18_08000
  • RSO11539.1
 67845 - 69920 (-) phospholipase C, phosphocholine-specific
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    • DMH18_08005
    • RSO11540.1
    		 70462 - 71388 (+) hypothetical protein
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      • DMH18_08010
      • RSO11789.1
      		 71692 - 73143 (+) amino acid permease
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        • DMH18_08015
        • RSO11541.1
        		 73242 - 74198 (+) GNAT family N-acetyltransferase
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          • DMH18_08020
          • RSO11542.1
          		 74299 - 75285 (+) lantibiotic ABC transporter
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            • DMH18_08025
            • RSO11543.1
            		 75443 - 76360 (+) RNA polymerase subunit sigma-70
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              • DMH18_08030
              • RSO11544.1
              		 76385 - 77506 (-) prephenate dehydrogenase
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                • DMH18_08035
                • RSO11545.1
                		 77503 - 78912 (-) GntR family transcriptional regulator
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                  • DMH18_08040
                  • RSO11546.1
                  • hppD
                  		 79300 - 80397 (+) 4-hydroxyphenylpyruvate dioxygenase
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                    • DMH18_08045
                    • RSO11547.1
                    		 80390 - 81541 (+) alpha-hydroxy-acid oxidizing protein
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                      • DMH18_08050
                      • RSO11548.1
                      		 81669 - 81890 (-) ferredoxin
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                        • DMH18_08055
                        • RSO11549.1
                        		 81937 - 83151 (-) cytochrome P450
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                          • DMH18_08060
                          • RSO11790.1
                          		 83166 - 84356 (-) cytochrome P450
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                            • DMH18_08065
                            • RSO11550.1
                            		 84389 - 85921 (-) tryptophan halogenase
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                              • DMH18_08070
                              • RSO11551.1
                              		 85970 - 87256 (-) sodium:proton antiporter
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                                • DMH18_08075
                                • RSO11552.1
                                		 87324 - 87548 (-) MbtH family protein
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                                  • DMH18_08080
                                  • RSO11553.1
                                  		 87545 - 94102 (-) non-ribosomal peptide synthetase
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                                    • DMH18_08085
                                    • RSO11554.1
                                    		 94136 - 109021 (-) non-ribosomal peptide synthetase
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                                      • DMH18_08090
                                      • RSO11555.1
                                      		 109093 - 113724 (-) non-ribosomal peptide synthetase
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                                        • DMH18_08095
                                        • RSO11556.1
                                        		 113742 - 123104 (-) non-ribosomal peptide synthetase
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                                          • DMH18_08100
                                          • RSO11557.1
                                          		 123218 - 125284 (-) ABC transporter
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                                            • DMH18_08105
                                            • RSO11558.1
                                            		 125764 - 126732 (-) streptomycin biosynthesis protein
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                                              • DMH18_08110
                                              • RSO11559.1
                                              		 127165 - 127722 (-) transposase
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                                                • DMH18_08115
                                                • RSO11560.1
                                                • aroF
                                                		 127986 - 129041 (-) 3-deoxy-7-phosphoheptulonate synthase
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                                                  • DMH18_08120
                                                  • RSO11561.1
                                                  		 129415 - 132360 (-) hypothetical protein
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                                                    • DMH18_08125
                                                    • RSO11562.1
                                                    		 132957 - 138197 (+) hypothetical protein
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                                                      • DMH18_08130
                                                      • RSO11563.1
                                                      		 138194 - 139039 (+) hypothetical protein
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                                                        • DMH18_08140
                                                        • RSO11564.1
                                                        		 139587 - 141278 (+) acetolactate synthase
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                                                          • DMH18_08145
                                                          • RSO11565.1
                                                          • frc
                                                          		 141289 - 142545 (+) formyl-CoA transferase
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                                                            Biosynthesis information

                                                            Biosynthetic modules

                                                            Name
                                                            Unk01
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            DMH18_08080
                                                            Substrates
                                                            4-hydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk02
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            DMH18_08085
                                                            Substrates
                                                            4-hydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk03
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            DMH18_08085
                                                            Substrates
                                                            4-hydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk04
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            DMH18_08085
                                                            Substrates
                                                            tyrosine (evidence: Sequence-based prediction, Mass spectrometry)
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk05
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            DMH18_08090
                                                            Substrates
                                                            4-hydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk06
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            DMH18_08095
                                                            Substrates
                                                            4-hydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk07
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            DMH18_08095
                                                            Substrates
                                                            tryptophan (evidence: Sequence-based prediction, Mass spectrometry)
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Annotation changelog

                                                            Entry version: 2

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-10-07
                                                            Update chemical activity to schema version 2.11
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 1

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-09-15
                                                            Entry added
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2022-09-15
                                                            Updated bioactivity data
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2022-09-15
                                                            Added NRP substrate specificities
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            Detailed domain annotation
                                                            Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
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