BGC0002638 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002638 (Streptomyces sp. WAC 00631)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	73,156	misaugamycin A/misaugamycin B	NRPS:Type I	100%

BGC0002638 - Region 1 - NRPS

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Location: 1 - 73,156 nt. (total: 73,156 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 73,157
Label		BGC0002638

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002638	1.00	NRP	misaugamycin A, misaugamycin B	Streptomyces sp. WAC 00631
BGC0000326	0.42	NRP	isocomplestatin	Streptomyces lavendulae
BGC0001050	0.38	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001629	0.36	NRP	jessenipeptin	Pseudomonas sp. QS1027
BGC0002437	0.35	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0001925	0.35	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0002341	0.34	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000457	0.34	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000426	0.33	NRP	sevadicin	Paenibacillus larvae
BGC0002631	0.33	RiPP	myxarylin	Pyxidicoccus fallax

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002638	1.00	NRP	misaugamycin A, misaugamycin B	Streptomyces sp. WAC 00631
BGC0000326	0.73	NRP	isocomplestatin	Streptomyces lavendulae
BGC0001050	0.71	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001629	0.69	NRP	jessenipeptin	Pseudomonas sp. QS1027
BGC0002437	0.68	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0001925	0.68	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0002341	0.68	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000457	0.67	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000426	0.67	NRP	sevadicin	Paenibacillus larvae
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 73156:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Hpg) + (D-Trp) + (D-Hpg) + (D-Hpg - D-Hpg - D-Hpg) + (Hpg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

DMH02_027320

Search NORINE for peptide: strict or relaxed

AMP-binding (468..863): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DVFHLGLLCK
Nearest Stachelhaus code(s):: Hpg DVFHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

DMH02_027330

Search NORINE for peptide: strict or relaxed

AMP-binding (6..405): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: trp (Trp)

Stachelhaus prediction details:

Stachelhaus sequence:: DVAAVGEVTK
Nearest Stachelhaus code(s):: Trp DVAAVGEVTK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

DMH02_027335

Search NORINE for peptide: strict or relaxed

AMP-binding (473..867): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DVFHLGLLCK
Nearest Stachelhaus code(s):: Hpg DVFHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

DMH02_027340

Search NORINE for peptide: strict or relaxed

AMP-binding (465..861): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DVFHLGLLCK
Nearest Stachelhaus code(s):: Hpg DVFHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2015..2409): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFHLGLLCK
Nearest Stachelhaus code(s):: Hpg DAFHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3548..3946): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code(s):: Hpg DASTVAAVCK (100% 8Å match); Tyr DASTVAAVCK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

DMH02_027345

Search NORINE for peptide: strict or relaxed

AMP-binding (465..860): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFHLGLLCK
Nearest Stachelhaus code(s):: Hpg DAFHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1525..1953): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ---LGGTVTK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

DMH02_027395

AMP-binding (41..364): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GLGFVGRVIK
Nearest Stachelhaus code(s):: nohBza GLGLVGAIIK (41% 8Å match)
Stachelhaus code match:: 70% (weak)