BGC0002641 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002641 (Bacillus velezensis FZB42)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	19,451	bacillothiazol A/bacillothiazol B/bacillothiazol C/bacillothiazol D/bacillothiazol E/bacillothiazol F/bacillothiazol G/bacillothiazol H/bacillothiazol I/bacillothiazol J/bacillothiazol K/bacillothiazol L/bacillothiazol M/bacillothiazol N	NRPS:Type I	100%

BGC0002641 - Region 1 - NRPS

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Location: 1 - 19,451 nt. (total: 19,451 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 19,452
Label		BGC0002641

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002641	1.00	NRP	bacillothiazol A, bacillothiazol B, bacillothiazol C, bacillothiazol D, bacillothiazol E, bacillothiazol F, bacillothiazol G, bacillothiazol H, bacillothiazol I, bacillothiazol J, bacillothiazol K, bacillothiazol L, bacillothiazol M, bacillothiazol N	Bacillus velezensis FZB42
BGC0002405	0.31	Saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0001219	0.27	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0002410	0.26	NRP	frankobactin A1, frankobactin A2, frankobactin A3, frankobactin B1, frankobactin B2, frankobactin B3, frankobactin C1	Frankia sp. CH37
BGC0002412	0.26	NRP	holomycin	Photobacterium galatheae
BGC0002091	0.25	NRP	holomycin	Yersinia ruckeri ATCC 29473
BGC0000347	0.24	NRP	equibactin	Streptococcus equi subsp. equi
BGC0000373	0.23	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001831	0.23	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001909	0.22	Polyketide	strobilurin A	Strobilurus tenacellus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002641	1.00	NRP	bacillothiazol A, bacillothiazol B, bacillothiazol C, bacillothiazol D, bacillothiazol E, bacillothiazol F, bacillothiazol G, bacillothiazol H, bacillothiazol I, bacillothiazol J, bacillothiazol K, bacillothiazol L, bacillothiazol M, bacillothiazol N	Bacillus velezensis FZB42
BGC0002405	0.65	Saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0001219	0.61	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0002410	0.60	NRP	frankobactin A1, frankobactin A2, frankobactin A3, frankobactin B1, frankobactin B2, frankobactin B3, frankobactin C1	Frankia sp. CH37
BGC0002412	0.59	NRP	holomycin	Photobacterium galatheae
BGC0002091	0.58	NRP	holomycin	Yersinia ruckeri ATCC 29473
BGC0000347	0.58	NRP	equibactin	Streptococcus equi subsp. equi
BGC0000373	0.56	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001831	0.56	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001909	0.54	Polyketide	strobilurin A	Strobilurus tenacellus

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 19451:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Cys - Cys - Cys) + (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

RBAM_027420

CAL_domain (32..470): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 205.8
NH2: 10.9
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

RBAM_027450

Search NORINE for peptide: strict or relaxed

AMP-binding (560..951): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code(s):: Cys DLYNLSLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1608..1999): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code(s):: Cys DLYNLSLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2656..3047): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code(s):: Cys DLYNLSLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)