LOCUS       BGC0002643              9229 bp    DNA     linear   BCT 29-MAR-2021
DEFINITION  Aetokthonos hydrillicola Thurmond2011 AETX gene cluster, complete
            sequence.
ACCESSION   BGC0002643
VERSION     BGC0002643
KEYWORDS    .
SOURCE      Aetokthonos hydrillicola Thurmond2011
  ORGANISM  Aetokthonos hydrillicola Thurmond2011
            Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales;
            Hapalosiphonaceae; Aetokthonos.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 18:08:16
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9229
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..1791
                     /gene="aetA"
     CDS             1..1791
                     /codon_start=1
                     /gene="aetA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119:halogenase (Score: 271.4; E-value: 2.6e-82)"
                     /gene_kind="biosynthetic-additional"
                     /note="NAD(P)/FAD-dependent halogenase"
                     /product="AetA"
                     /protein_id="QNL15171.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.4e-09, bitscore:
                     26.2, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Trp_halogenase (E-value: 1.1e-09,
                     bitscore: 26.3, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYDVVICGGGLAGLSLARQLKMTMPELSVLILEKTSGEVPVSPYK
                     VGESLDETSNFYLSNILQLESYLQEHQLHKLGLRWFFGGGNLPLETRPEIGPPEFPSIR
                     ARHVDRKALENHLVQLNKESGVAHFTGVLVKDILLSEDDSPHEVLYTQQGGNHFTVKCR
                     WLVDATGRRRYLQSKLNLTQPSGHRANAVWWQLEGKHSLDKMADDADWLSRNNHQRWFS
                     TNHLMGDGYWVWVIPLITGNTSIGIVAAEEMHPLSKHSNYQSAMKWLEEHEPHFAKFIQ
                     TSTAQNFLAVKDFCYHSQQVFSEKRWSCVGDSAIFTDPFYSPGVVMLAYSNCLTVKMIE
                     LDHQNQLTAEIVQQFNNLLLRDIGHNYLQIYQDNYPVFGSFNVMSIKLFWDAVYIWFFP
                     GALFFQQHFTNLEVLSNFSRIAQRYLALNQRVQKLFQDWGQAIKSQNFPCFLAYDISYK
                     PTCLGKPRANGKRFFFDIFKEAHFSLVEKKDTQQYLADLEVQMQELEIWAQVIFRHALN
                     QVMPERLSQFPEPFWVNVWAIGLNPEKWEEDRLFQPETEPQVDLRNYILAELPDDHYPP
                     GAEPVTTSSVDNPAYVAAVN"
     source          1..9229
                     /collection_date="2011"
                     /country="USA"
                     /db_xref="taxon:2712845"
                     /isolation_source="J. Strom Thurmond reservoir, bottom side
                     of leaves of Hydrilla verticillata"
                     /mol_type="genomic DNA"
                     /organism="Aetokthonos hydrillicola Thurmond2011"
                     /strain="Thurmond2011"
     misc_feature    1..9229
                     /note="AETX gene cluster"
     subregion       1..9229
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002643"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..9229
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            2143..3600
                     /gene="aetB"
     CDS             2143..3600
                     /codon_start=1
                     /gene="aetB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 207; E-value: 8.6e-63)"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome P450"
                     /product="AetB"
                     /protein_id="QNL15172.1"
                     /sec_met_domain="p450 (E-value: 3.2e-96, bitscore: 311.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLELQSSIQSKSIITPPGPRGLPLVGSLAPLLGKHLHVTLNQLA
                     KEYGNIFQIRMGIRTVVALNGIKTITEALIKQQKNFINRADFEFFSIPADGGLFEAKSG
                     QAWEKHRGIAAKAMRTFVIDKSDRVEHHIMEEAAKLADSFLNYDGQPFDPDIPSSLAVG
                     SIIHRVLFGTRGSSEDPDFVATARILQLFPPVTQRILISEFLPKILRPVFFIFNQKSLQ
                     DFQDVPATVDKLVSKNIEQHRNSFDPDNIRDMTDAFLKAANDLSESDKKNFNLSENHIL
                     RGTLMQLTGAGLEPVLIQLIWALLYMIAYPDIQAKIQQELDEVVGLGQQPCLNHRGKLP
                     FTEACINEILRHSSISPIPFLYASTTDTTINGYSVHQGTPVIINLYSLTRDERYWQNPD
                     KFDPDRFLDENCKIRSDLLDKFYPFGIGQRRCMGEYLARLEIFIFFTTLMHKCKLEKVP
                     REKLSLEPKPGFFMRPQKYNIIAKSRF"
     gene            3680..4204
                     /gene="aetC"
     CDS             3680..4204
                     /NRPS_PKS="Domain: Polyketide_cyc (29-160). E-value:
                     2.8e-21. Score: 68.0. Matches aSDomain:
                     nrpspksdomains_aetC_Polyketide_cyc.1"
                     /codon_start=1
                     /gene="aetC"
                     /product="AetC"
                     /protein_id="QNL15173.1"
                     /transl_table=11
                     /translation="MSKSENLKDVEIEVEKLEGRHRRIFAQIQISYPLEQVWQVITDYE
                     AFAKFMPNLKECRRLEHPTGGIRLEQVRTLSFLGLNFSGRSVFDIAEEFPDKIHYQLVE
                     GDLKAFSGDWRLAPANLGEKAGVVLTYNFSILPNPLLPIVVVERVFSHDVPVSLLAIRQ
                     RVEDLFGSGSK"
     aSDomain        3767..4159
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aetC_Polyketide_cyc.1"
                     /domain_subtypes="Polyketide_cyc"
                     /evalue="2.80E-21"
                     /label="aetC_Polyketide_cyc.1"
                     /locus_tag="aetC"
                     /protein_end="160"
                     /protein_start="29"
                     /score="68.0"
                     /tool="antismash"
                     /translation="ISYPLEQVWQVITDYEAFAKFMPNLKECRRLEHPTGGIRLEQVRT
                     LSFLGLNFSGRSVFDIAEEFPDKIHYQLVEGDLKAFSGDWRLAPANLGEKAGVVLTYNF
                     SILPNPLLPIVVVERVFSHDVPVSLLA"
     gene            4241..4960
                     /gene="aetD"
     CDS             4241..4960
                     /codon_start=1
                     /gene="aetD"
                     /note="putative methyltransferase"
                     /product="AetD"
                     /protein_id="QNL15174.1"
                     /transl_table=11
                     /translation="MKAILQLILEKRQEFEKLPCFEFVRDETISPEERLILYPCIAAFA
                     LNFRDLNRYDYRDDNSSDYYQKIINIHTQEDAKHWEWFLNDLELLGFDKTMRFSEALRF
                     VWSDDLLHTRRLCHNIAVLSHDLEPVMKMVVIEAMETAGLVIFHALAKPGESIAKATRR
                     KYLYVADSHVEVETGHAVGTENIITILEQTQLSSEQEEKAKEIVNKVFQWSTNLIGEFE
                     RYVKAHRSEKAQPTAAY"
     gene            5479..6885
                     /gene="aetE"
     CDS             5479..6885
                     /NRPS_PKS="Domain: Beta_elim_lyase (46-424). E-value:
                     8.8e-87. Score: 282.8. Matches aSDomain:
                     nrpspksdomains_aetE_Beta_elim_lyase.1"
                     /codon_start=1
                     /gene="aetE"
                     /note="tryptophanase; tryptophan indole-lyase"
                     /product="AetE"
                     /protein_id="QNL15175.1"
                     /transl_table=11
                     /translation="MTHHPPEPFRIKMVEPIKLLDRDARKAAIRRSGYSLFGLRSEEIF
                     IDFFTDSGTTAMSQTQWSAMFEGDEAYAGGSSYFRLAEVIHDIFGFDYFLPTHQGRAAE
                     NILSTCMVKPDQYVPSNMHFDTTYANIRARGGRPINLVIDEAHHPGSYHLFKGNMNIQK
                     LRAFIEEVGPNQIPFGMITVTNNAGGGQPVSMENLRAVSQTYKEFGIPFFIDACRFAEN
                     AYLIKLREPDYADKTPLEISREMFSLADGITMSAKKDGMVNIGGFIAMNDELLFEQARN
                     ELLLREGFPTYGGLAGRDLDAMAVGFHEVLQEDYLAYRLAQTAYLGDRLRELEIPIVEP
                     PGGHAIYIDAGRLLPHISQKEFPAHALTVELYLEGGIRTVEIGSLSFAYPDPKTNQMVY
                     PNLELVRLALPRRVYTQSHLDYVAETLGKTVTRCAQIPGYRITYAPKVLRQFTAQLEPI
                     KLDAHPSATL"
     aSDomain        5617..6750
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aetE_Beta_elim_lyase.1"
                     /evalue="8.80E-87"
                     /label="aetE_Beta_elim_lyase.1"
                     /locus_tag="aetE"
                     /protein_end="424"
                     /protein_start="46"
                     /score="282.8"
                     /tool="antismash"
                     /translation="DFFTDSGTTAMSQTQWSAMFEGDEAYAGGSSYFRLAEVIHDIFGF
                     DYFLPTHQGRAAENILSTCMVKPDQYVPSNMHFDTTYANIRARGGRPINLVIDEAHHPG
                     SYHLFKGNMNIQKLRAFIEEVGPNQIPFGMITVTNNAGGGQPVSMENLRAVSQTYKEFG
                     IPFFIDACRFAENAYLIKLREPDYADKTPLEISREMFSLADGITMSAKKDGMVNIGGFI
                     AMNDELLFEQARNELLLREGFPTYGGLAGRDLDAMAVGFHEVLQEDYLAYRLAQTAYLG
                     DRLRELEIPIVEPPGGHAIYIDAGRLLPHISQKEFPAHALTVELYLEGGIRTVEIGSLS
                     FAYPDPKTNQMVYPNLELVRLALPRRVYTQSHLDYVAE"
     gene            7223..9229
                     /gene="aetF"
     CDS             7223..9229
                     /codon_start=1
                     /gene="aetF"
                     /note="NAD(P)/FAD-dependent halogenase; tryptophan
                     brominase"
                     /product="AetF"
                     /protein_id="QNL15176.1"
                     /transl_table=11
                     /translation="MLEVCIIGFGFSAIPLVRELARTQTEFQIISAESGSVWDRLSESG
                     RLDFSLVSSFQTSFYSFDLVRDYEKDYYPTAKQFYEMHERWRSVYEEKIIRDFVTKIEN
                     FKDYSLISTRSGKTYEAKHVVLATGFDRLMNTFLSNFDNHVSNKTFVFDTMGDSANLLI
                     AKLIPNNNKIILRTNGFTALDQEVQVLGKPFTLDQLESPNFRYVSSELYDRLMMSPVYP
                     RTVNPAVSYNQFPLIRRDFSWVDSKSSPPNGLIAIKYWPIDQYYYHFNDDLENYISKGY
                     LLNDIAMWLHTGKVILVPSDTPINFDKKTITYAGIERSFHQYVKGDAEQPRLPTILING
                     ETPFEYLYRDTFMGVIPQRLNNIYFLGYTRPFTGGLANITEMQSLFIHKLITQPQFHQK
                     IHQNLSKRITAYNQHYYGAAKPRKHDHTVPFGFYTEDIARLIGIHYQPNECRSVRDLLF
                     YYAFPNNAFKYRLKGEYAVDGVDELIQKVNDKHDHYAQVFVQALSIRNMNSDEAAEWDH
                     SARRFSFNDMRHKEGYRAFLDTYLKAYRQVENISVDDTVVDEEWNFMVKEACQVRDKVA
                     PNIEEKTHYSKDEDVNKGIRLILSILDSDISSLPDSNGSRGSGNLKEGDRLCKFEAQSI
                     EFIRRLLQPKNYELLFIRESTVSPGSHRHGETA"
ORIGIN
        1 atgtatgatg ttgtgatttg tggggggggg ctggctggtc tcagtttagc gagacaatta
       61 aagatgacca tgccggaact gtcggttttg attttggaaa aaacatccgg tgaggtgcca
      121 gtgtcacctt acaaagttgg tgaatctcta gatgagacca gcaattttta tctgtcaaat
      181 attttgcaac ttgaatccta cctccaggaa catcaactgc ataaattagg actgcggtgg
      241 ttttttggcg gtggtaacct acctctagaa actaggcccg aaattgggcc tcctgaattt
      301 cccagtattc gcgcccgtca tgtggatcgc aaggctttag aaaatcactt ggtgcagcta
      361 aataaagaaa gtggtgtcgc tcacttcaca ggtgtattag tcaaggacat cctcttatct
      421 gaggatgact cacctcatga ggttctgtac acccagcaag ggggtaatca tttcaccgtc
      481 aaatgtcgct ggttagtaga tgcaacgggg cgtcggcggt atttacagtc taaactcaac
      541 ttgacccagc ccagcggcca tcgcgctaat gcggtatggt ggcaacttga gggtaaacat
      601 agcctagata agatggcaga cgatgctgat tggctatcac gtaacaatca ccaaagatgg
      661 ttctctacta atcatttgat gggtgatggc tattgggtat gggtcatccc tctcattacg
      721 ggcaatacca gtattggtat tgttgcagca gaggagatgc accccttatc caaacatagc
      781 aattatcaat cagcaatgaa gtggttagaa gaacacgaac cacactttgc caaattcatc
      841 caaacttcta ctgctcaaaa cttcctcgcg gtgaaagatt tctgttacca ctcccagcaa
      901 gttttctctg agaagagatg gtcttgtgtt ggtgattctg ctatctttac ggatcctttt
      961 tacagtccag gggtagtcat gctggcctat agcaactgct tgacagttaa aatgatcgaa
     1021 ctggatcatc agaatcaatt aactgcagag attgtccagc aattcaacaa cctattgcta
     1081 cgtgacatcg gccataatta cctgcaaatt tatcaggata attatccagt atttggttca
     1141 ttcaatgtga tgtcaatcaa actattttgg gatgcggttt atatctggtt tttcccagga
     1201 gcgttattct tccaacagca ctttacaaat ctagaagtgt tgagcaattt ttcccgcata
     1261 gctcagcgtt atttggcctt gaatcaaagg gtgcaaaaac ttttccaaga ttggggtcaa
     1321 gccatcaaat cccaaaattt tccttgtttt ttagcttatg atattagcta caaaccaacc
     1381 tgccttggga agccacgagc gaatggaaag cggttcttct ttgacatttt caaagaagct
     1441 cattttagcc tggtggagaa aaaggatacg cagcaatatt tggctgactt ggaggtacaa
     1501 atgcaggaat tggaaatctg ggcgcaagtc atctttcgcc atgcattgaa ccaagttatg
     1561 ccagaaagat tgagtcaatt tcccgaaccc ttttgggtta atgtctgggc aattggtcta
     1621 aatccagaaa aatgggaaga agatcgctta ttccagcctg aaactgaacc ccaagtagac
     1681 ctgcgaaatt acatcctggc ggaactacct gacgatcatt atccgccagg tgcagaacca
     1741 gtaactactt ctagtgttga taatcccgct tacgtcgcag ccgtcaatta gggtgaagtg
     1801 attaaagcaa tgcgagttcg acaaatataa aaaacccctc tccaaacctc tcccctgcga
     1861 gcggcgtctg tgccaacttg tagcaagtgg ctttaaaggc taaattttcg ttggtaatca
     1921 agagacatct ccgaaaatga atctagaacc tttgtgcagc ttgggctgat acctaatttc
     1981 tggagatgtc ttgtctaagg atatttctga ccctttcagc gtcggagaga ggttgggcaa
     2041 aggttcaccg aattcacttt aaagcaatca ccttggtaaa aactcggata accgctacaa
     2101 catccttgtt aacctttttt ctagccaacc taggagatac tcatgaccct ggaattacaa
     2161 tcttccatac aatcaaaaag cataatcaca ccgcctggtc cacgtggatt acccttagtc
     2221 ggctccttgg ctcccctact gggtaaacac ctacatgtca ccttgaatca actagccaaa
     2281 gagtacggta acatcttcca gattcgcatg ggtatccgaa ctgtggttgc actcaacgga
     2341 attaagacca tcacagaagc tttgataaag cagcagaaga attttatcaa tagagcggat
     2401 tttgaattct ttagcatacc agctgatgga ggattgtttg aggctaagag tgggcaagcc
     2461 tgggaaaaac atcgtggtat agcagctaaa gccatgcgta cttttgtgat tgataagtca
     2521 gaccgtgttg aacatcatat tatggaagaa gccgccaaac tagcagatag cttcttaaac
     2581 tatgacggtc aacctttcga tcctgatata ccctcatctc tagctgttgg gagtattatt
     2641 cacagagtat tattcggcac aagaggttct tctgaagatc cggattttgt tgcgactgcc
     2701 cgcattctcc agctctttcc tcccgttact caaagaatcc tcattagcga attcttgccg
     2761 aaaatacttc gaccagtatt ttttatcttc aatcaaaaat cattacaaga ttttcaggat
     2821 gttcctgcta cggtagacaa attggtttca aagaatatag agcagcatcg taactcattc
     2881 gaccccgaca atatacggga catgaccgat gcgtttttga aagctgccaa cgatctaagt
     2941 gagtctgaca aaaaaaactt caatttaagc gaaaaccata ttcttagggg aacattgatg
     3001 cagctaacag gagctggatt ggagcctgtg ttaattcagt tgatttgggc tttactttac
     3061 atgattgcct atccagatat tcaggcgaaa attcagcaag aactagatga agtggttggc
     3121 ttgggacaac agccatgttt aaatcatcgt ggcaaattac catttactga agcttgtatt
     3181 aatgaaattc ttcgccactc ttctattagt cctattccct tcctttatgc ttccaccact
     3241 gacacgacta tcaatggtta ctctgttcac caaggtactc ctgtaattat aaacctttat
     3301 agtttgacac gggacgaacg ctattggcaa aaccctgata aatttgatcc ggatcgattt
     3361 ttagatgaaa attgtaagat tagaagcgat cttctcgata agttttatcc gtttggtatt
     3421 ggacaacgtc gatgtatggg agagtatcta gcgcgtcttg aaatctttat attttttacg
     3481 actcttatgc ataagtgcaa acttgaaaag gtgcctagag agaagttgag tttggagcca
     3541 aaaccaggat tctttatgcg tccacaaaag tacaacatta tagctaaatc ccgcttctaa
     3601 gctaacttgc gttgagtttt cacgcacaaa gattgtgaaa aatcaacttt agtctaattg
     3661 tcatttacag cacctagaaa tgagtaaatc agaaaatcta aaagatgtag aaatagaagt
     3721 tgagaagttg gagggaaggc accgacggat atttgcccaa atccagattt cttatccatt
     3781 agaacaagtc tggcaagtta tcacggacta tgaagctttt gctaagttca tgcccaattt
     3841 gaaggagtgc cgacgtttag agcatccgac tggaggcatt cgcttagaac aagttcgcac
     3901 tttaagcttt ctgggcttga atttttctgg tcgatctgtt tttgacatcg cagaggaatt
     3961 tcctgacaaa attcattatc agctagttga gggggactta aaggctttct ccggtgactg
     4021 gcgattagct cctgcaaatc taggcgaaaa agctggagtt gttctcacgt ataacttttc
     4081 aattttgccc aatcccttgc tcccaatagt ggtagttgag cgcgtcttca gccatgacgt
     4141 gccagtgagt ctgctggcga ttcgtcagcg agtagaagat ttgtttggat ccggatcgaa
     4201 gtaaatcaaa gtgaaatagt accagaacag gaggaaaatt atgaaagcta ttctacagtt
     4261 aattctagaa aaaagacagg aatttgagaa gctaccttgc tttgaatttg ttcgggatga
     4321 gacaattagc ccagaagaac gactaattct ttatccatgc attgcggcct tcgctttgaa
     4381 ttttcgtgac ctcaaccgat atgattatcg tgatgataat tcgagcgact actatcaaaa
     4441 aataatcaac atccatactc aagaagacgc aaagcattgg gagtggtttt tgaacgatct
     4501 ggaactactt ggatttgata aaaccatgcg cttttcagaa gccttgcgct ttgtttggag
     4561 cgatgacctg ctgcacacac gccgattgtg tcacaatata gcggttctct cgcacgacct
     4621 agaacccgtt atgaaaatgg tcgttattga agctatggaa accgccggcc ttgttatctt
     4681 tcatgctctg gcaaagccag gggagtccat agccaaggca actcgacgga aatacttgta
     4741 tgtggctgac tcgcatgtgg aagtcgaaac cggtcatgct gtgggcactg agaatataat
     4801 aaccatctta gaacaaacgc agttgtccag tgagcaagag gaaaaggcta aagagatcgt
     4861 gaacaaagta ttccaatggt ctactaactt aataggagag ttcgagcgat acgtgaaagc
     4921 tcaccgcagc gagaaagcac agccgaccgc agcttattag gcaatacaat tcagataagc
     4981 ccaaaaccct gatttagagt tagagacgcg atttatcccg tcttcaaaga ccaattatct
     5041 acgccaataa cccttaactg aacagttagg ggatttcacg agtttttagc cggcgatgga
     5101 gctaggatta cctatcgtag gatcgagtta ccccgagaag acatcttcga tggacttaaa
     5161 cagcagttcg tctatgtcta tacgtcggat gacatagaca acacgcagct tttcactcga
     5221 agctcccctg gcgttgtggt tctggattat aacgacgatg gcgatgaagt ctttttcctc
     5281 aacgagatca gcgtctttct acatgggtct ggggacagtt tccattgacg agcgagtacg
     5341 gttcgttgtt tagtcctgta agtagcaagt gtacaataac ttacgctaag gctgtaatca
     5401 aatcacagca atggtttcag aagctatgat ttgtaaagtg tcgtctaaaa aagaacaaac
     5461 aatatttgaa ggtagaagat gacccatcat cccccagaac catttcggat caagatggtt
     5521 gaacccatca aactgcttga tcgcgatgcc cgcaaagctg ctatacgccg ttctggttac
     5581 agcctgttcg gtctgcgctc ggaggaaata ttcatcgatt tttttacaga ctctggcacc
     5641 accgcgatga gccagacgca atggtcagct atgtttgaag gtgatgaagc ctatgctggg
     5701 ggaagctcct atttccggct ggcagaagtg atacatgaca ttttcggctt tgactatttt
     5761 ttgcccaccc accaaggtcg cgcagcagaa aatattttga gtacctgtat ggtcaaacca
     5821 gatcaatatg taccttctaa tatgcacttt gatactacct atgcgaacat ccgcgcacgg
     5881 ggtggtcgcc ctattaactt agtcattgac gaagcccacc atcctggttc ttatcacctt
     5941 tttaaaggga atatgaacat tcaaaaatta cgagccttta tcgaagaggt aggaccaaac
     6001 cagatccctt ttggcatgat cacagtgaca aacaacgctg gaggaggtca acccgtttcg
     6061 atggaaaatc taagagcagt ctcccagaca tacaaagagt ttggaattcc gtttttcatc
     6121 gatgcttgtc gctttgcaga gaatgcctac ttgatcaagc tacgggaacc agactatgca
     6181 gataaaacac cgctggaaat cagccgtgaa atgttttctc tagctgacgg aataaccatg
     6241 agtgccaaaa aagatggcat ggtaaatatc ggtggcttca tcgccatgaa cgacgaatta
     6301 ctgtttgagc aggcacgcaa tgagttgctc ctgcgtgagg gttttcccac ctacggtgga
     6361 ctggcgggtc gggatttaga tgccatggcg gttggttttc atgaagtact ccaggaagat
     6421 tatcttgcct atcgtttggc acaaacagct tatctgggag accgtttacg ggaattagag
     6481 attccaattg ttgagcctcc tggaggacat gcaatatata tagatgctgg acggctatta
     6541 cctcatatct cccaaaaaga atttcctgct cacgctctga cagtggaact ctatttagag
     6601 ggtggaatcc gcacagtaga aataggctca ctctcttttg cttatcctga cccaaagacc
     6661 aaccagatgg tatatcccaa cttagagttg gttcgtctag cgctcccaag acgagtatac
     6721 acccaaagcc atttggacta cgtggctgaa acattaggca aaaccgtgac gcggtgcgct
     6781 caaatacctg gctaccgaat aacctacgcg cctaaggtgt tgcgccaatt tactgctcag
     6841 cttgagccta taaaattaga cgctcatccg tcagcaacat tgtagagact tctatgtttc
     6901 cagattaacc aaaacttccg agaattgaac aagacagtcc cgatgaaaaa attttcaccg
     6961 ccaggcatgt aagaggaata ttccctactc cctcttacaa gtcagaaggc gggaggcaga
     7021 gggcagaaag ttccgtacat tcggcgattc aacgccactt gaaccggagc caccaaattt
     7081 ccaatttggt gggggtctta aacccttggt cctttcagtc gcgcagaggg ttcgggtatt
     7141 cagagaaggg gatgaatctc ttctgccctc tacctttcct tgaaaattct tcttaataga
     7201 tgagtaagtg aggtaaaacc taatgttaga agtttgtatt attggctttg gatttagtgc
     7261 gattcctttg gttcgtgaac tagctcgtac ccaaacagag ttccagatca tttctgcaga
     7321 gagcggcagt gtatgggatc gtttgagcga gagtggacgt ctagatttca gtctggtgtc
     7381 cagttttcaa accagttttt attcatttga cctggtaaga gattatgaga aagattacta
     7441 cccgacagct aaacagtttt atgaaatgca tgaacgatgg cgtagcgttt atgaagaaaa
     7501 aattattagg gattttgtta ctaaaataga gaacttcaag gactatagtc tgatttccac
     7561 ccgttcagga aaaacttatg aagcaaagca tgttgttctt gcgacaggct ttgatcgact
     7621 catgaataca ttcttgagta attttgataa ccacgtctcc aataaaactt ttgtgtttga
     7681 tacaatggga gattcggcta atttgcttat tgccaaactc atacccaaca ataataaaat
     7741 tatcctgaga accaatgggt ttactgcatt agatcaggag gttcaagtac ttggaaaacc
     7801 atttactttg gatcagttag aatctcccaa ctttagatat gtttcgagtg agctttatga
     7861 taggttgatg atgagtcctg tctacccaag aactgtaaac ccagcagttt catataatca
     7921 atttcccttg atcagacgtg attttagttg ggtcgatagt aagtcgtcgc ctccaaacgg
     7981 tttgattgct ataaaatatt ggcccattga tcagtattat tatcacttta atgacgattt
     8041 agagaactat atttctaagg ggtacttgtt gaatgatata gcgatgtggc ttcacacggg
     8101 taaagtgatt cttgttccct ctgatacccc aatcaacttt gataaaaaaa ctattactta
     8161 cgcagggatt gagagatcat tccatcaata tgttaaaggg gatgctgaac aacctagact
     8221 ccccaccatc ctgatcaacg gagaaacccc atttgaatat ctgtacagag atacctttat
     8281 gggtgtcatt cctcaacggt tgaataacat ttatttcttg ggatatactc gcccatttac
     8341 aggggggctt gcaaatatta ctgaaatgca aagtttattc attcacaaac ttatcactca
     8401 gccccagttt catcaaaaga tacatcaaaa cttgagtaag cgaattacgg cttacaatca
     8461 gcattactat ggtgccgcca aaccccgtaa gcatgaccat acagttccct ttggctttta
     8521 cacagaggat attgcaaggt taatcgggat tcattatcaa cccaacgagt gtcgttctgt
     8581 cagagaccta ctcttctact atgcttttcc caataatgcc ttcaagtatc gcctgaaggg
     8641 agagtatgct gttgacggag ttgatgagtt aattcagaaa gtcaatgaca agcatgacca
     8701 ttatgcccag gtttttgttc aagccctaag cattagaaat atgaactcag acgaagctgc
     8761 cgagtgggat cattcagcca gacgtttttc cttcaacgat atgagacaca aagaaggcta
     8821 cagagcattt cttgatactt acctcaaagc ctatcgtcaa gtcgaaaata tatctgttga
     8881 tgacactgtt gtagatgagg agtggaattt catggtcaaa gaggcttgtc aggttaggga
     8941 caaggttgct cctaacattg aggaaaaaac tcactactcg aaagatgaag acgttaacaa
     9001 gggaatccgg ttgattttat ctatcctgga ttcagatatt tcatctctgc ctgactccaa
     9061 cggtagtagg ggtagtggta atttgaagga gggtgatcgc ctatgtaagt ttgaagctca
     9121 aagtatagag ttcatccgga ggttgcttca acctaaaaac tacgagctac tttttattcg
     9181 tgaatcgacg gtgtctcctg gttcacacag acatggagag actgcataa
//
