BGC0002643: aetokthonotoxin biosynthetic gene cluster from Aetokthonos hydrillicola Thurmond2011
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Location: 1 - 9,229 nt. (total: 9,229 nt).
This entry is originally from NCBI GenBank MT225528.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
Tailoring
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002643
Short description aetokthonotoxin biosynthetic gene cluster from Aetokthonos hydrillicola Thurmond2011
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
MT225528.1
1 - 9229
via Enzymatic assays
Compounds
  • aetokthonotoxin
Species Aetokthonos hydrillicola Thurmond2011 [taxonomy]
References
Chemical products information
aetokthonotoxin Evidence: X-ray crystallography [2], NMR [1]
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C17H6Br5N3
Chemical database entries
CyanoMetDB CyanoMetDB_2448
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QNL15171.1
  • aetA
 1 - 1791 (+) flavin-dependent tryptophan halogenases
  • Halogenation
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  • QNL15172.1
  • aetB
 2143 - 3600 (+) cytochrome P450
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    • QNL15173.1
    • aetC
    		 3680 - 4204 (+) AetC
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      • QNL15174.1
      • aetD
      		 4241 - 4960 (+) nitrile synthase
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        • QNL15175.1
        • aetE
        		 5479 - 6885 (+) pyridoxal phosphate (PLP)-dependent tryptophanase
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          • QNL15176.1
          • aetF
          		 7223 - 9229 (+) single-component flavin-dependent tryptophan halogenase
          • Halogenation
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          Biosynthesis information

          Biosynthetic paths

          aetokthonotoxin
          Pathway: AetF/AetD/AetB/AetE/AetA [1]
          Annotation changelog

          Entry version: 2

          Date
          Changes
          Submitters
          Reviewers
          2024-06-08
          MIBiG v4 annotathon
          • (ID: E3BGRDDSXQC4BVVGLJQTVJNI)
          • (ID: NHJ6M55E7ZEHUFNMEG4QIZWY)
          • (ID: 5YHEW7BMWFDRKNSFQDCWZN7L)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 1

          Date
          Changes
          Submitters
          Reviewers
          2022-09-15
          Entry added
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          Tailoring functions
          Tailoring enzymes detected in this region
          Oxidoreductases: oxygenase
          aetB: cytochrome P450
          smcogs
          SMCOG1034: cytochrome P450
          Transferases: Halogenation halogenase
          aetA: conventional flavin-dependent halogenase
          halogenases
          conventional flavin-dependent halogenase
          MITE
          MITE0000127Halogenation (identity: 100.00%)
          smcogs
          SMCOG1119: halogenase
          aetF: unconventional flavin-dependent halogenase
          halogenases
          unconventional flavin-dependent halogenase
          MITE
          MITE0000126Halogenation (identity: 100.00%)
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