BGC0002643: aetokthonotoxin biosynthetic gene cluster from Aetokthonos hydrillicola Thurmond2011
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 1 - 9,229 nt. (total: 9,229 nt).
This entry is originally from NCBI GenBank MT225528.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002643
Short description aetokthonotoxin biosynthetic gene cluster from Aetokthonos hydrillicola Thurmond2011
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
MT225528.1
1 - 9229
via Enzymatic assays
Compounds
  • aetokthonotoxin
Species Aetokthonos hydrillicola Thurmond2011 [taxonomy]
References
Chemical products information
aetokthonotoxin Evidence: X-ray crystallography [2], NMR [1]
Copy SMILES
C17H6Br5N3
Chemical database entries
CyanoMetDB CyanoMetDB_2448
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QNL15171.1
  • aetA
1 - 1791 (+) flavin-dependent tryptophan halogenases
    copy AA seq
    copy Nt seq
    • QNL15172.1
    • aetB
    2143 - 3600 (+) cytochrome P450
      copy AA seq
      copy Nt seq
      • QNL15173.1
      • aetC
      3680 - 4204 (+) AetC
        copy AA seq
        copy Nt seq
        • QNL15174.1
        • aetD
        4241 - 4960 (+) nitrile synthase
          copy AA seq
          copy Nt seq
          • QNL15175.1
          • aetE
          5479 - 6885 (+) pyridoxal phosphate (PLP)-dependent tryptophanase
            copy AA seq
            copy Nt seq
            • QNL15176.1
            • aetF
            7223 - 9229 (+) single-component flavin-dependent tryptophan halogenase
              copy AA seq
              copy Nt seq
              Biosynthesis information

              Biosynthetic paths

              aetokthonotoxin
              Pathway: AetF/AetD/AetB/AetE/AetA [1]
              Annotation changelog

              Entry version: next

              Date
              Changes
              Submitters
              Reviewers
              MIBiG v4 annotathon
              • (ID: E3BGRDDSXQC4BVVGLJQTVJNI)
              • (ID: NHJ6M55E7ZEHUFNMEG4QIZWY)
              • (ID: 5YHEW7BMWFDRKNSFQDCWZN7L)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              Entry added
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Similar known gene clusters from MIBiG 4.0
              Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
              Click on reference genes to show details of similarities to genes within the current region.
              Click on an accession to open that entry in the MiBIG database.