BGC0002685 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002685 (Rothia mucilaginosa ATCC 25296)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	16,397	enterobactin	NRPS:Type I	100%

BGC0002685 - Region 1 - NRPS

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Location: 1 - 16,397 nt. (total: 16,397 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 16,398
Label		BGC0002685

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002685	1.00	NRP	enterobactin	Rothia mucilaginosa ATCC 25296
BGC0000343	0.36	NRP	enterobactin	Pseudomonas sp. J465
BGC0002359	0.28	NRP	dudomycin A	Streptomyces albus subsp. chlorinus
BGC0000417	0.27	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001833	0.25	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0002493	0.24	NRP	parabactin	Paracoccus denitrificans PD1222
BGC0000410	0.24	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001825	0.23	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758	0.23	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844	0.23	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002685	1.00	NRP	enterobactin	Rothia mucilaginosa ATCC 25296
BGC0000343	0.69	NRP	enterobactin	Pseudomonas sp. J465
BGC0002359	0.62	NRP	dudomycin A	Streptomyces albus subsp. chlorinus
BGC0000417	0.60	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001833	0.58	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0002493	0.58	NRP	parabactin	Paracoccus denitrificans PD1222
BGC0000410	0.57	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001825	0.57	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758	0.56	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844	0.56	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 16397:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ROTMU0001_0987

Search NORINE for peptide: strict or relaxed

AMP-binding (51..463): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: TMPAQGVVNK
Nearest Stachelhaus code(s):: diOH-Bz TMPSQGVVNK (91% 8Å match)
Stachelhaus code match:: 90% (moderate)

ROTMU0001_0989

Search NORINE for peptide: strict or relaxed

AMP-binding (573..996): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHVSLVDK
Nearest Stachelhaus code(s):: Ser DVWHVSLVDK (88% 8Å match)
Stachelhaus code match:: 100% (strong)