BGC0002686: madurastatin D1 biosynthetic gene cluster from Actinomadura sp. WMMA1423
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Location: 793,880 - 907,895 nt. (total: 114,016 nt).
This entry is originally from NCBI GenBank NZ_CP041244.1.

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core biosynthetic genes
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General
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Biosynthesis
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KnownClusterBlast
NRPS/PKS domains
General information about the BGC

MIBiG accession | BGC0002686
Short description | madurastatin D1 biosynthetic gene cluster from Actinomadura sp. WMMA1423
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- NRPS (Type I)

Loci
NZ_CP041244.1
793880 - 907542
via
Compounds

- madurastatin D1
- madurastatin D2
- (-)-Madurastatin C1

Species Actinomadura sp. WMMA1423 [taxonomy]
References

- [1] Madurastatin D1 and D2, Oxazoline Containing Siderophores Isolated from an Actinomadura sp.. Yan, J et al., Organic Letters (2019) DOI:10.1021/acs.orglett.9b02159
- [2] Madurastatin D1 and D2, Oxazoline Containing Siderophores Isolated from an . Yan JX et al., Org Lett (2019) PMID:31380646

Chemical products information
madurastatin D1 Evidence:
(no structure information available)
madurastatin D2 Evidence:
(no structure information available)
(-)-Madurastatin C1 Evidence:
(no structure information available)
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
FKD65_RS04195 WP_141576235.1 | 793880 - 795058 (+) | acyl-CoA dehydrogenase family protein |  |  | copy AA seq copy Nt seq
FKD65_RS04200 WP_141576236.1 | 795193 - 795402 (+) | HGxxPAAW family protein |  |  | copy AA seq copy Nt seq
FKD65_RS04205 WP_141576237.1 | 795405 - 795587 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04210 WP_141576238.1 | 795953 - 797068 (+) | glutamate--cysteine ligase |  |  | copy AA seq copy Nt seq
FKD65_RS04215 WP_141576239.1 | 797258 - 798205 (+) | sensor histidine kinase |  |  | copy AA seq copy Nt seq
FKD65_RS04220 WP_240809957.1 | 798215 - 799132 (-) | phosphotransferase |  |  | copy AA seq copy Nt seq
FKD65_RS04225 WP_141576241.1 | 799303 - 799539 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04230 WP_141576242.1 | 799787 - 800230 (+) | DoxX family membrane protein |  |  | copy AA seq copy Nt seq
FKD65_RS04235 WP_141576243.1 | 800293 - 800925 (+) | GNAT family N-acetyltransferase |  |  | copy AA seq copy Nt seq
FKD65_RS04240 WP_240810283.1 | 801212 - 801997 (+) | SAM-dependent methyltransferase |  |  | copy AA seq copy Nt seq
FKD65_RS04245 WP_141576245.1 | 802196 - 803494 (+) | acyltransferase |  |  | copy AA seq copy Nt seq
FKD65_RS04250 WP_141576246.1 | 803609 - 804787 (+) | helix-turn-helix domain-containing protein |  |  | copy AA seq copy Nt seq
FKD65_RS04255 WP_205718541.1 | 804794 - 805693 (-) | alpha/beta hydrolase-fold protein |  |  | copy AA seq copy Nt seq
FKD65_RS04260 WP_141576247.1 | 805690 - 806589 (-) | DMT family transporter |  |  | copy AA seq copy Nt seq
FKD65_RS44005 WP_168220944.1 | 806780 - 806980 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS44010 | <807266 - 807556 (+) | D-beta-D-heptose 1-phosphate adenosyltransferase |  |  | copy AA seq copy Nt seq
FKD65_RS04270 WP_141576248.1 | 807602 - 808912 (-) | ABC transporter substrate-binding protein |  |  | copy AA seq copy Nt seq
FKD65_RS04275 WP_205718542.1 | 808830 - 810032 (-) | branched-chain amino acid ABC transporter permease |  |  | copy AA seq copy Nt seq
FKD65_RS04280 WP_141576249.1 | 810037 - 810915 (-) | branched-chain amino acid ABC transporter permease |  |  | copy AA seq copy Nt seq
FKD65_RS04285 WP_141576250.1 | 810915 - 811622 (-) | ABC transporter ATP-binding protein |  |  | copy AA seq copy Nt seq
FKD65_RS04290 WP_141576251.1 | 811615 - 812394 (-) | ABC transporter ATP-binding protein |  |  | copy AA seq copy Nt seq
FKD65_RS04295 WP_141576252.1 | 812628 - 813230 (+) | TetR/AcrR family transcriptional regulator |  |  | copy AA seq copy Nt seq
FKD65_RS04300 WP_240809958.1 | 813265 - 814896 (-) | long-chain fatty acid--CoA ligase |  |  | copy AA seq copy Nt seq
FKD65_RS44745 WP_205718543.1 | 815080 - 815475 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04310 WP_141576253.1 | 815508 - 816371 (+) | PHB depolymerase family esterase |  |  | copy AA seq copy Nt seq
FKD65_RS04315 WP_141576254.1 | 816433 - 816639 (-) | MbtH family protein |  |  | copy AA seq copy Nt seq
FKD65_RS04320 WP_141576255.1 | 816723 - 818018 (-) | lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein |  |  | copy AA seq copy Nt seq
FKD65_RS04325 WP_141576256.1 | 818018 - 819037 (-) | iron-siderophore ABC transporter substrate-binding protein |  |  | copy AA seq copy Nt seq
FKD65_RS04330 WP_141576257.1 | 819141 - 831182 (-) | non-ribosomal peptide synthetase |  |  | copy AA seq copy Nt seq
FKD65_RS04335 WP_240809959.1 | 831271 - 832581 (+) | salicylate synthase |  |  | copy AA seq copy Nt seq
FKD65_RS45345 WP_240809960.1 | 832926 - 833387 (+) | zinc finger domain-containing protein |  |  | copy AA seq copy Nt seq
FKD65_RS04345 WP_141576258.1 | 833606 - 835048 (+) | toxin glutamine deamidase domain-containing protein |  |  | copy AA seq copy Nt seq
FKD65_RS04350 WP_141576259.1 | 835075 - 835374 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04355 WP_141576260.1 | 835417 - 836034 (+) | exonuclease |  |  | copy AA seq copy Nt seq
FKD65_RS04360 WP_205718545.1 | 836110 - 836310 (+) | isochorismatase family protein |  |  | copy AA seq copy Nt seq
FKD65_RS04365 WP_141576261.1 | 836780 - 837358 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04370 WP_205718546.1 | 837401 - 837946 (-) | alpha-ketoglutarate-dependent dioxygenase AlkB |  |  | copy AA seq copy Nt seq
FKD65_RS04375 WP_141576263.1 | 838997 - 840658 (+) | TROVE domain-containing protein |  |  | copy AA seq copy Nt seq
FKD65_RS04380 WP_141576264.1 | 840696 - 841313 (-) | GyrI-like domain-containing protein |  |  | copy AA seq copy Nt seq
FKD65_RS04385 WP_141576265.1 | 841300 - 841893 (-) | PadR family transcriptional regulator |  |  | copy AA seq copy Nt seq
FKD65_RS04390 WP_141576266.1 | 842468 - 843235 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04395 WP_141576267.1 | 843366 - 845969 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04400 WP_141576268.1 | 845974 - 848061 (-) | DEAD/DEAH box helicase |  |  | copy AA seq copy Nt seq
FKD65_RS04405 WP_141576269.1 brxD | 848061 - 849410 (-) | BREX system ATP-binding protein BrxD |  |  | copy AA seq copy Nt seq
FKD65_RS04410 WP_168220945.1 pglZ | 849410 - 852049 (-) | BREX-2 system phosphatase PglZ |  |  | copy AA seq copy Nt seq
FKD65_RS04415 WP_141576271.1 | 852046 - 855678 (-) | phage resistance protein |  |  | copy AA seq copy Nt seq
FKD65_RS04420 WP_141576272.1 pglX | 855721 - 859266 (-) | BREX-2 system adenine-specific DNA-methyltransferase PglX |  |  | copy AA seq copy Nt seq
FKD65_RS04425 WP_141576273.1 | 859540 - 860187 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04430 WP_141576274.1 | 860209 - 860775 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04440 WP_141576275.1 | 861528 - 862514 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04445 WP_205718547.1 | 862817 - 863251 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04450 WP_141576276.1 | 863244 - 864230 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS44015 WP_168220946.1 | 864716 - 865471 (-) | TIGR04222 domain-containing membrane protein |  |  | copy AA seq copy Nt seq
FKD65_RS44020 WP_168220947.1 | 865741 - 867270 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04460 WP_141576277.1 | 867257 - 867706 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04465 WP_141576278.1 | 867755 - 868240 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04470 WP_240809961.1 | 869166 - 869987 (+) | helix-turn-helix transcriptional regulator |  |  | copy AA seq copy Nt seq
FKD65_RS04475 WP_141576279.1 | 869984 - 870175 (+) | DUF397 domain-containing protein |  |  | copy AA seq copy Nt seq
FKD65_RS04480 WP_141576280.1 pglX | 870308 - 873910 (-) | BREX-2 system adenine-specific DNA-methyltransferase PglX |  |  | copy AA seq copy Nt seq
FKD65_RS04485 WP_168220948.1 pglW | 873907 - 878211 (-) | BREX system serine/threonine kinase PglW |  |  | copy AA seq copy Nt seq
FKD65_RS04490 WP_240809962.1 | 878470 - 880194 (+) | DUF262 domain-containing protein |  |  | copy AA seq copy Nt seq
FKD65_RS04495 WP_141576283.1 | 880191 - 881159 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04500 WP_141576284.1 | 881235 - 882803 (-) | AMP-binding protein |  |  | copy AA seq copy Nt seq
FKD65_RS04505 WP_141586355.1 | 882806 - 883207 (-) | aspartate 1-decarboxylase |  |  | copy AA seq copy Nt seq
FKD65_RS04510 WP_141576285.1 entS | 883280 - 884524 (+) | enterobactin transporter EntS |  |  | copy AA seq copy Nt seq
FKD65_RS04515 WP_141576286.1 | 884533 - 887895 (-) | non-ribosomal peptide synthetase |  |  | copy AA seq copy Nt seq
FKD65_RS04520 WP_141576287.1 | 887948 - 888964 (-) | iron chelate uptake ABC transporter family permease subunit |  |  | copy AA seq copy Nt seq
FKD65_RS04525 WP_141576288.1 | 888961 - 890010 (-) | iron chelate uptake ABC transporter family permease subunit |  |  | copy AA seq copy Nt seq
FKD65_RS45350 | 890224 - >890328 (+) | TetR/AcrR family transcriptional regulator |  |  | copy AA seq copy Nt seq
FKD65_RS45355 WP_240810284.1 | 890500 - 890814 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
FKD65_RS04535 WP_141576290.1 | 890807 - 891709 (+) | ABC transporter ATP-binding protein |  |  | copy AA seq copy Nt seq
FKD65_RS04540 WP_141576291.1 | 891706 - 893343 (+) | ABC transporter permease |  |  | copy AA seq copy Nt seq
FKD65_RS04545 WP_141576292.1 | 893448 - 893843 (+) | STAS domain-containing protein |  |  | copy AA seq copy Nt seq
FKD65_RS44025 WP_168220949.1 | 893887 - 895653 (-) | sensor histidine kinase |  |  | copy AA seq copy Nt seq
FKD65_RS04555 WP_141576293.1 | 895954 - 896628 (-) | response regulator transcription factor |  |  | copy AA seq copy Nt seq
FKD65_RS04560 WP_141576294.1 | 896619 - 898433 (-) | histidine kinase |  |  | copy AA seq copy Nt seq
FKD65_RS04565 WP_240809963.1 dinB | 898600 - 899775 (-) | DNA polymerase IV |  |  | copy AA seq copy Nt seq
FKD65_RS04570 WP_240809964.1 | 899917 - 902841 (-) | glycoside hydrolase family 48 protein |  |  | copy AA seq copy Nt seq
FKD65_RS04575 WP_141576297.1 | 902951 - 903988 (-) | LacI family DNA-binding transcriptional regulator |  |  | copy AA seq copy Nt seq
FKD65_RS04580 WP_141576298.1 | 904282 - 905772 (+) | cellulase family glycosylhydrolase |  |  | copy AA seq copy Nt seq
FKD65_RS04585 | 905816 - 907542 (+) | glycoside hydrolase family 6 protein |  |  | copy AA seq copy Nt seq

Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

#### Entry version: 2

Date
Changes
Submitters
Reviewers
2024-08-12
MIBiG v4 annotathon

- (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2022-09-15
Entry added

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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