BGC0002688 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002688 (Planobispora rosea)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	19,983	benarthin/dibenarthin	NRPS:Type I	100%

BGC0002688 - Region 1 - NRPS

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Location: 1 - 19,983 nt. (total: 19,983 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 19,984
Label		BGC0002688

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002688	1.00	NRP	benarthin, dibenarthin	Planobispora rosea
BGC0000343	0.41	NRP	enterobactin	Pseudomonas sp. J465
BGC0001185	0.38	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000401	0.34	NRP	paenibactin	Paenibacillus elgii B69
BGC0000309	0.33	NRP	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0002075	0.32	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000457	0.31	NRP	vicibactin	Rhizobium etli CFN 42
BGC0002017	0.31	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0002405	0.31	Saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0002287	0.28	NRP	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002688	1.00	NRP	benarthin, dibenarthin	Planobispora rosea
BGC0000343	0.73	NRP	enterobactin	Pseudomonas sp. J465
BGC0001185	0.70	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000401	0.67	NRP	paenibactin	Paenibacillus elgii B69
BGC0000309	0.67	NRP	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0002075	0.65	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000457	0.65	NRP	vicibactin	Rhizobium etli CFN 42
BGC0002017	0.64	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0002405	0.64	Saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0002287	0.62	NRP	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 19983:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Arg - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

EV45_RS28695

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AMP-binding (30..419): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: PMPAQGVVNK
Nearest Stachelhaus code(s):: diOH-Bz PMPAQGVVNK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

EV45_RS28710

Search NORINE for peptide: strict or relaxed

AMP-binding (484..866): Arg

nrpys: Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DADDVGHVDK
Nearest Stachelhaus code(s):: Arg DADDVGLVDK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1544..1930): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)