BGC0002691 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002691 (Vibrio neptunius)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	25,301	amphibactin B/amphibactin C/amphibactin D/amphibactin E/amphibactin H/amphibactin S/amphibactin T/amphibactin V	NRPS:Type I	100%

BGC0002691 - Region 1 - NRPS

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Location: 1 - 25,301 nt. (total: 25,301 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 25,302
Label		BGC0002691

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002691	1.00	NRP	amphibactin B, amphibactin C, amphibactin D, amphibactin E, amphibactin H, amphibactin S, amphibactin T, amphibactin V	Vibrio neptunius
BGC0001133	0.40	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.36	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002135	0.33	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000426	0.33	NRP	sevadicin	Paenibacillus larvae
BGC0002518	0.33	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001833	0.30	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825	0.29	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128	0.29	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002437	0.29	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002691	1.00	NRP	amphibactin B, amphibactin C, amphibactin D, amphibactin E, amphibactin H, amphibactin S, amphibactin T, amphibactin V	Vibrio neptunius
BGC0001133	0.72	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.69	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002135	0.67	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000426	0.66	NRP	sevadicin	Paenibacillus larvae
BGC0002518	0.66	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001833	0.64	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825	0.63	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128	0.63	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002437	0.62	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 25301:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - Ser) + (D-X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

TW84_00900

AMP-binding (519..926): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGECTGGVTK
Nearest Stachelhaus code(s):: OH-Orn DGEGSGGVTK (76% 8Å match); Fo-OH-Orn DGEVCGGVTK (62% 8Å match)
Stachelhaus code match:: 80% (moderate)

TW84_00905

Search NORINE for peptide: strict or relaxed

AMP-binding (461..871): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGECTGGVTK
Nearest Stachelhaus code(s):: Orn DGEGSGGVTK (74% 8Å match); OH-Orn DGEGSGGVTK (74% 8Å match); Fo-OH-Orn DGEVCGGVTK (62% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1966..2379): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGECTGGVTK
Nearest Stachelhaus code(s):: OH-Orn DGEGSGGVTK (76% 8Å match); Fo-OH-Orn DGEVCGGVTK (62% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (3033..3443): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHISLIDK
Nearest Stachelhaus code(s):: Ser DVWHISLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)