LOCUS       BGC0002692             11626 bp    DNA     linear   BCT 06-MAR-2019
DEFINITION  Kribbella speibonae strain SK5 662.SK5.1-2-SK5.00002, whole genome
            shotgun sequence.
ACCESSION   BGC0002692
VERSION     BGC0002692
KEYWORDS    .
SOURCE      Kribbella speibonae
  ORGANISM  Kribbella speibonae
            Bacteria; Actinobacteria; Propionibacteriales; Kribbellaceae;
            Kribbella.
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 11:26:06
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 1414401
            Orig. end    :: 1426027
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..11626
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="Other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..11626
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1492..1737
                     /locus_tag="E0H58_16210"
     CDS             1492..1737
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="E0H58_16210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="TCC25647.1"
                     /transl_table=11
                     /translation="MATNQALALMLIFGFSFAIAKNWRKVLVFLGALAMTAALFGVYSI
                     VEAVRDIDTIHSDVDPAGVQAGHPDTTAQSAAPLGR"
     gene            1796..3304
                     /locus_tag="E0H58_16215"
     CDS             1796..3304
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276:PfkB domain protein (Score: 99.5; E-value:
                     3.6e-30)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:PF00294.22"
                     /locus_tag="E0H58_16215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="TCC25648.1"
                     /transl_table=11
                     /translation="MLDSSEDQSEKVRVLANALEKLRTHDGLTAERLRADRTVAEPLLG
                     LAATRRYANVHELDLPDAAVALVCDCVRDDLYDSQRIVADAVLGLGVLGQPLTEAGIDT
                     HVTRALYELALGRRRETLLSHWHPLHAALSAAPIPAPSDRYLRGTTELAVLRELAYQLA
                     RRDIYSVGAKNVVRTDTGPTSDNSSRGRVVVVGGAVMDATFRTKQLPAPETSTEALGFS
                     LSPGGKGLMQAVASARLGLHTSLVAAVATDRFGDAIVDYLEREHVDTSLLKRVPNADTP
                     FTGVFQQQLGDSIAVNWRNEKQIRLESSDVFDRREELTGSDVLLVTFEVPRDTLEDTVA
                     LAHDRSDDRPIVIVTPGQPYTHDEVSADTLAQIDYLVAHAWELEPFARHSAFDPDSAAR
                     TLLAFGVKTLCLLVTGGCNAYSRPMRDVLQIAAPPAIYKESSVARDAFCAALAAQLIDN
                     ESKFSEDVARWATAAMSCAASDFPRRNSLPTRRRINDLLEVSRH"
     gene            complement(3307..3612)
                     /locus_tag="E0H58_16220"
     CDS             complement(3307..3612)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="E0H58_16220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="TCC25649.1"
                     /transl_table=11
                     /translation="MRESSESLPDHCWLEIGPPENPDRRIVDLTCDQSLTFAGEGVLCS
                     SHSSIRTTYGVSYEASLRLGPEELDQDEVQDRLGQLVTALGPDHLPVLPERLKRFF"
     gene            complement(3874..4803)
                     /locus_tag="E0H58_16225"
     CDS             complement(3874..4803)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="E0H58_16225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="TCC25650.1"
                     /transl_table=11
                     /translation="MLTTAVVAKADNAYLNPELPRTFRTEDSRTQFTDRLLDLAPPLWG
                     VSRRELVVRTRLHLPCYADSAGRVGYLGALAVVTSNAARLRRDQHAVRHLIPRREYSLS
                     DLEFRKVGEDADRVLGSLHYLRNARRGSLNFALVDKISGTPVTLCSVSPLEWKRVADQL
                     ALQFGLPQESVWDLSRVYSFDAAPPNAVSYLLAQVRKYFQKRGDVKLLTTVVDPNLGFT
                     GSSYLASNWQRWITVRARPYLYYRGSYMSLRQMRVAFPAIRSIDELCAADRRARRSVVD
                     LDDSWIFCCRIRGATERLAPEEQHRILR"
     gene            complement(5001..6734)
                     /locus_tag="E0H58_16230"
     CDS             complement(5001..6734)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012920804.1"
                     /locus_tag="E0H58_16230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IucA/IucC family protein"
                     /protein_id="TCC25651.1"
                     /sec_met_domain="IucA_IucC (E-value: 6.7e-74, bitscore:
                     237.9, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVWTQCSSELLAKLISQFCTEGLLEPVDNRLELGAVSYVFEATR
                     GGFGSWRVDPTSIRRTTAGILGNDESEIATDPIRFFVDAADVLGVDGSTVAGYVAELTS
                     TLAADVRMASTALPAAELLELHHTRLEGHLTGHPLLVANKGRLGFSAADSEQYAPEART
                     PLHLVWLAVRRGLAEFRGTPDLSEHSVISRELDPETIAAFRAQLDDPDAYVWLPCHPWQ
                     LDHVIRTQWARELATGEIVVLGESPDEYLPTQSIRTMVNISNPSRYQVKLPLKILNTSV
                     YRGIPEHCTLAAPMITQWLRGLWSRDETFQQLGTELLGEVASVTVPHPELSTHPGIPYQ
                     WTETLGVIWRDPVDPRLQAGETVWPLAAVLHPGFASAAIARSGTNAETWLAHLLSTLLR
                     PLLHLLHHYGITVNPHGENLAVICSPTGLPTRLVIKDLVDDINLSTDPIVARGPEPDSH
                     TRVLPRKPWPILRQYVVDALLLGVLNPLAAHHLIPEQTFWGVVRGEVHRYTEKHPEYTA
                     RLAATALTAESFLRYPLNGYRLTLGYTDLDTRPPIPVTGTIPNPLHTVQSVYLEMILPT
                     E"
     gene            complement(6731..7987)
                     /locus_tag="E0H58_16235"
     CDS             complement(6731..7987)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080:lysine/ornithine N-monooxygenase (Score: 386.5;
                     E-value: 2.3e-117)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004019734.1"
                     /locus_tag="E0H58_16235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lysine 6-monooxygenase"
                     /protein_id="TCC25652.1"
                     /transl_table=11
                     /translation="MYDVIAIGCGPFNLGLAALADGVDDVQLAVLDSRPEFTWHRGLMF
                     EDAMLQVSFLADLVSLVEPAHHLSFLSYLKDNDRLYQFYVREKFHPTRREYETYLRWCA
                     AQLDSLHFGHHVREAVWNGTSFELTVERGDSVEQFEARHLVVGVGTEPFVPAALAGLPT
                     ERFAHSADYLFRRDDLLRTGRVTVVGSGQSGAECFLDLLRSDAPAVSWLTRTAAFTPLD
                     YSKLVLEMTTPSYVDYFHALDEPVRDQLVKDQWRHYKGISSETLEDIHDILYSRDLSAA
                     PVELQVGVGVVSAVARADGLELTMLHADSGKTFQHMTGAVVAATGYRNRSLPFLESLQS
                     QIDHDAAGRWIINRDHSVRGALEGRIFVANADLHSHGVAAPDLGIGAIRNATILNSVAG
                     REVFRLPKSTAYTTFAIPG"
     gene            complement(7975..8445)
                     /locus_tag="E0H58_16240"
     CDS             complement(7975..8445)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203:putative siderophore biosynthesis protein (Score:
                     159.7; E-value: 2.3e-48)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012920802.1"
                     /locus_tag="E0H58_16240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="N-acetyltransferase"
                     /protein_id="TCC25833.1"
                     /transl_table=11
                     /translation="MAQPHIRRWWHQGWSVERWAQEIEQQAAGEHSTPYLVAADAEEFA
                     YVELYRVRHDRLAEYYAYGEEDRGVHVAIGDIARVGQGLGRRLLRWLVDEVLRAEPACA
                     QVVAEPDIENTPSVRAFAAAGFVQHGQLQLPEKTALLMVRTRAVQGGMTCTT"
     gene            complement(8502..10142)
                     /locus_tag="E0H58_16245"
     CDS             complement(8502..10142)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020389950.1"
                     /locus_tag="E0H58_16245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="siderophore synthetase"
                     /protein_id="TCC25653.1"
                     /sec_met_domain="IucA_IucC (E-value: 9.4e-66, bitscore:
                     211.2, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSAADSAADTAADAHLNAILRCYTRESSVPVAVGPLTLEAGGST
                     VTARVEHASRTGLHQFTDVQVDGVPAEPEELVRLLSADADPAEIDDLAARTAESVRNVA
                     LFVELADGQRGPGRFLELEQALLFGHLNHPAPKSRDGLSGDELAAYSPELGGRFAVHWF
                     EADAELVSSDQVAGAPSLQGLDAVQLMGALAGITPSPGRVLIPAHPWQAAAVAQRPRVA
                     SLISAGRVKALGPGGAQWYPTSSLRTVFHPDLPVMLKLSLGLRITNSRRESTPTELRRG
                     LEINRLLDAAYNAGTATAHPRFTIVRDPAWVALDEGGPLLTGLDVAVREVPADVNSYAC
                     LAGLVAPRPGGVSRLSAFAAEDPLGWTAAYIDNVLIPMLHLYAETGIGLEAHQQNTLVR
                     LDGAGRIKGGAYRDNQGYYLASSYLRGLLTITGLRDSTLAVVDDPIVDDRLTYYLLHNQ
                     ALAVVGCLAADGIADEGELLGVVRERLTLALPLLKAAGPSGDRLARRWLEAKTLPCKAN
                     MLTRLRGIDEVVAPLDAQSVYLDIPNPLL"
     gene            complement(10139..11626)
                     /locus_tag="E0H58_16250"
     CDS             complement(10139..11626)
                     /NRPS_PKS="Domain: Beta_elim_lyase (184-323). E-value:
                     4.9e-08. Score: 24.3. Matches aSDomain:
                     nrpspksdomains_E0H58_16250_Beta_elim_lyase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180:Decarboxylase, pyridoxal-dependent (Score: 328.7;
                     E-value: 8.7e-100)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012920800.1"
                     /locus_tag="E0H58_16250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="TCC25654.1"
                     /transl_table=11
                     /translation="MSQPARLTALPAPVRDPFAARWPLASTVSDRERGPLPHGSPGAVL
                     RRAAEVLGEPRIPSTGVGESAALDLIAGLLDEHGIDLSHPHAAAHLQPPVLQVAVDADA
                     LASASNASMDTYDSGPATLAIEQWVVRALASLAGFGPQADGVLTPGGSISNLLAILIAR
                     DSAAAAAGIDVRRNGLQGFDRPVVFCSELAHFSVQRACAALGLGEQAAITIPSDDNFRM
                     RTDVLAEELARSGRTPVAVVATAGTTDFGSVDPIAPIAALARQYGAWLHVDAAYGFGAL
                     FSERLAPLLADVPLADSVTLDLHKIGWQPAATSVLLVADRSRFAAFDRSVDYLNPADDI
                     DSGLDGLLGRSLQTTRRPDAVKVATTLTAYGRAGLGTMVDTCHELAHAAAARVVADSNL
                     ELLAPVTLTTVLFRVAGQGLDASGLDAVQGEVRRRLLTSGRVLIGRTKLPARGGRPAAV
                     ALKLTLLNPNATATDIEDLLDQVVATGLDVLTGEGAA"
     aSDomain        complement(10658..11074)
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_E0H58_16250_Beta_elim_lyase.1"
                     /evalue="4.90E-08"
                     /label="E0H58_16250_Beta_elim_lyase.1"
                     /locus_tag="E0H58_16250"
                     /protein_end="323"
                     /protein_start="184"
                     /score="24.3"
                     /tool="antismash"
                     /translation="PVVFCSELAHFSVQRACAALGLGEQAAITIPSDDNFRMRTDVLAE
                     ELARSGRTPVAVVATAGTTDFGSVDPIAPIAALARQYGAWLHVDAAYGFGALFSERLAP
                     LLADVPLADSVTLDLHKIGWQPAATSVLLVADRSR"
ORIGIN
        1 gggcatctat ctcgagacct acaagtcccg gaaagacatc tccctccggg atctgcaccg
       61 cctggccggc ggcggtgtgg gcgatcggcg actcgccctc gtgaatcaat ggcatgcgct
      121 ccaccgcgcg ctcgacgcag cacctccggc cgggccggca cccggcgaac acacactccg
      181 cagccgcctc gaacgagaag tcttcgaacg actgagtacc ttgctcgtca atccgaggtc
      241 gacgttcgag gtctccgcac ctggcgaacc gctcgcgatc tcgacggcgc agaccgtcga
      301 cgccaccgcg gccgggaagg tcatcgtggt cggcggggcc gccttcgacc acacctggcg
      361 catcggttcg gtgccgcccg taggaacctc caccatggcg atggcgttcg cccgtacccc
      421 cggcggcaaa ggcgtcagtc aggccgtcgc ggccgcccac ctggacctcg acgtgtccct
      481 gatcgccgcg gtggcgggcg acgacgacgg ccgcgagatc gaggcccacc tcgaacgcga
      541 aggcgtcgac atctcgctgc tccaccgagt cgagcgaccc ggcgccagaa cgccggctac
      601 cggaatctac gagctgccgt acggcaacag ctcagccgcg gtgttccgcg acatcgagct
      661 gggcgtcgcc accatcgatc ggcatgccga cgcactgtcc gcctgcgacg tactgctact
      721 gaccttcgag ctcccgcagt cggtcttgaa acgggttctc gacgtggtcg ctgacgcggc
      781 ggctccgccc gtcgtgatcg tcacaccggg gcaaccgtat tcggacgggc acctggtcag
      841 cccgctgctc cagcagatcg actacctcgt cgcacacctg tgggagctcg aggggttcgc
      901 cttctccgac gaagcgaagt acgaccctga actgctcagc gacgacctcc tgagccgggg
      961 cctgagatcc ctgtgcctgc tgagcgttcc cgatggcggc agcgtctacg agcaaggtag
     1021 ggcgacagca ctgcccagac cgcaccggaa catccaggaa gcgtcgatca cccgggatgc
     1081 cttctgcgcc gcgctggccg cccgcctgat cgaggaccga tcccgcacgg acaacacctt
     1141 cctctgggca gccgccgcaa tggcaagctt cgccgacacc taccaccggg cccccaccac
     1201 ccgaccgtcc cgtgcgaccg tcgaagaaca ctacgccgcc caactgccac gcgacgcggc
     1261 cagctgaatc tgccaactgg caagccggcc accgaattgg caaagcccac cgcccgacag
     1321 gccggtccga cggcgccaaa gtcggactgc ggcgccacaa atccgactct ggcggccaca
     1381 actgctcctg tcacgctcga agcagaggca ccacagcgcc ttcagcggag tcggcaggga
     1441 gtccgagccc ggagcccgcc ggccgcgcga gatcgaggat cgagggacgc catggcgacc
     1501 aaccaggcac tcgcattgat gctcatcttc ggcttttcgt tcgcgatcgc caagaactgg
     1561 aggaaggtac tcgtcttcct cggcgcactg gccatgaccg cggcgctctt cggcgtctac
     1621 tccatcgtcg aggcggtccg cgacatcgac acgatccaca gcgacgtgga ccccgccggc
     1681 gtgcaggccg ggcacccgga caccactgca cagtcggccg cacctctagg acgctgacac
     1741 acttggcgcc gtggccggcg ggccacggcg cctatcacag agatggtgag gcccaatgct
     1801 cgacagcagc gaagaccagt cggagaaggt gcgggtgctc gccaacgccc tcgagaaact
     1861 tcggacgcat gatggcctca ccgccgagcg tctccgcgcg gaccgcacgg tagccgagcc
     1921 actgctgggc ctcgccgcga cccgccgcta cgcgaacgtc cacgaactcg atcttcctga
     1981 cgcggcagtt gccttggtct gcgactgtgt ccgcgacgat ctctacgatt cccaacggat
     2041 cgtcgcggac gcggtgctcg ggctcggtgt tctcgggcag ccgctcacgg aagccggcat
     2101 cgacacgcat gtcacccggg ctctgtacga gctcgccctc ggccgccgcc gggagacgct
     2161 cctgagccac tggcatccat tgcacgcagc cctgtccgca gctccgatcc cagcgccgag
     2221 cgaccgctat ctgcgcggta cgacggagtt ggccgtactg cgtgagctcg cgtaccaact
     2281 ggctcgccgg gacatctact cggtcggggc gaagaacgtc gtacggacgg acaccggacc
     2341 cacctcggac aactcgtcgc gtggccgggt tgtggttgtc ggcggcgcgg tgatggacgc
     2401 caccttccgg accaagcagc ttccggctcc cgagacatcg accgaggcgc tcggcttcag
     2461 cctctcccct ggtggcaaag gcctgatgca agcagttgcc tcagcgcggc tcggcctgca
     2521 cacctcgctc gtggccgcgg tagccaccga ccggttcggt gacgcgatcg tcgactacct
     2581 cgagagggag cacgtggaca cgtcgctcct caagcgggtc ccgaacgccg acacgccctt
     2641 caccggggtg ttccagcaac agctcggcga cagcatcgcc gtcaactggc gcaacgagaa
     2701 acagatccgc ctggagtcca gcgacgtgtt cgaccgccgc gaggagctca cgggaagcga
     2761 cgtactcctg gtcacgttcg aggtgccccg cgacaccttg gaggacacgg tcgcgctggc
     2821 gcacgatcgg tccgacgacc gtccgatcgt gatcgtcacc cccggccagc cgtacaccca
     2881 cgacgaggtc tcggccgaca cgctcgcgca gatcgactac ctcgtcgcac acgcgtggga
     2941 gttggaaccg ttcgcgcgcc actccgcgtt cgaccccgac tccgcggcac gcacgctgct
     3001 tgccttcggc gtcaagactc tgtgcctgct cgtcaccggc ggctgcaacg cgtactcacg
     3061 tccgatgcgc gacgtcctcc agatcgccgc gcccccggcg atctacaagg agtcgtcggt
     3121 cgctcgcgac gccttctgtg ccgcactggc ggcccagctg atcgacaacg agagcaagtt
     3181 ctccgaggac gtagcccgct gggcgacggc tgccatgtcg tgcgcggcct ccgatttccc
     3241 acgccggaac tcgctgccga cccgccgacg catcaacgat ctgctcgagg tgagccggca
     3301 ctgacctcag aagaatctct tcagccgctc gggcaggacc ggaagatggt cgggaccgag
     3361 ggccgtgaca agttgtccca gccgatcctg gacctcgtcc tggtcgagct cctcgggacc
     3421 gagccggaga cttgcctcgt aggagacccc gtaggtcgtg cggatgctgc tgtgggacga
     3481 gcacaggaca ccttcgccgg cgaaggtcag ggactggtcg cacgtcaggt cgacgattcg
     3541 ccggtcaggg ttctccggag gcccgatctc cagccagcaa tgatccggaa ggctctccga
     3601 tgactcacgc acggcccaca catcgccgta gcaatagacc gccggtaggt ggtgaacttc
     3661 ggtcagcacc gccagcagcc aggcggaggt cacgccgcac tgacccgtcg agggtcgatc
     3721 tctgtgatcg gcgaagcgcc aatggaccgt cttctcgccc cacgccgtcg agatgagggc
     3781 tcggtacgcc ggcagccgcg ctgcccagca cgagcaggcc gcagtagcag ggcaaccaca
     3841 cagagtcacc cgcgcgatgc tagcaggctc ggctcagcgg aggatgcggt gctgctcctc
     3901 cggcgccaaa cgttccgtcg cgccgcggat ccggcagcag aagatccagg agtcgtcgag
     3961 gtcgaccacg cttctcctgg cccgccgatc cgccgcgcag agttcgtcga tactccggat
     4021 cgccggaaag gccactcgca tctggcgcag gctcatatag ctgccgcggt aatacaggta
     4081 cggccgggct cggacagtta tccaacgctg ccaattcgac gccaagtagc tggatccggt
     4141 gaaccccagg ttcgggtcca cgactgtcgt caacagtttg acgtcgccgc gcttctggaa
     4201 gtacttgcgc acctgcgcga gaaggtacga caccgcgttc ggaggcgccg cgtcgaacga
     4261 gtacacccgg gacagatccc agaccgactc ctgcggcaag ccgaactgca gagcgagctg
     4321 gtccgccacc cgcttccact ccagtggcga gacgctgcac agggtcaccg gcgtaccgct
     4381 gatcttgtcg accagggcga agttgagaga accgcgtctg gcgttccgca ggtagtgcag
     4441 gctgcccagg acccgatcgg cgtcctcgcc gaccttccgg aactcgaggt ccgacaggga
     4501 atactcccgc cgaggaatca ggtgacgaac tgcatgctga tccctgcgca gccgggccgc
     4561 gttgctggtg acaacggcca gcgcacccag gtaacccacg cgacccgcgg agtccgcgta
     4621 gcagggcagg tgcagccggg tccgtacgac gagttcgcgc cggctcacgc cccacagcgg
     4681 cggcgcgaga tcgagcagcc ggtccgtgaa ttgcgtgcgg gaatcctccg tacgaaatgt
     4741 gcgcggcaac tcgggattca ggtaggcgtt atcggctttc gcgacgacgg cagtcgtcag
     4801 catgatcgac tgccgaccgt agagatgatt tcttgcgaga atttccagcg ggcagcctga
     4861 cggcatttca tgaattgccg gccgcagaaa ttctggccgg cctgcgtggc ggactgaggc
     4921 acgatcgccc tccccatctg ctcttccgcc gcgccccctg cgcgacggca acgagttcac
     4981 tggagattgt gggcgctgac ttattccgtt ggcaagatca tttctaaata caccgactga
     5041 acggtgtgca aggggtttgg aatggtgccg gttaccggta tcggtggacg ggtgtccagg
     5101 tcggtgtaac cgagtgtcag gcggtatccg ttcaagggat aacgcaggaa cgactcagcg
     5161 gtcagcgcgg tcgccgccag tcgggcggtg tattcggggt gtttttcggt gtagcggtgt
     5221 acttcgccgc gaactacacc ccagaaggtt tgttccggga tcaggtggtg ggcggcgagg
     5281 gggttgagga cgcctaggag gagggcgtct acgacgtact ggcggaggat gggccagggt
     5341 tttctgggga ggactctcgt gtgggagtcg ggttcggggc ctcgggcaac tatggggtcg
     5401 gtggagaggt tgatgtcgtc gaccaggtcc ttgatgacga ggcgggtggg gaggccggtg
     5461 ggtgagcaga tgacggcgag gttttcaccg tgtgggttga ccgtgatgcc gtagtggtga
     5521 agtaggtgga ggagggggcg taggagggtg gagaggaggt gggcgagcca ggtttcggcg
     5581 ttggtgccgg agcgagcgat cgcggctgat gcgaagccag gatggagtac ggcggccaac
     5641 ggccacaccg tctcgccggc ttggaggcgg gggtcgacgg ggtcgcgcca gatgacgccc
     5701 agggtttcgg tccactggta ggggatgccg gggtgggtgg agagttcggg gtgggggacg
     5761 gtgacggagg cgacctcgcc gaggagttcg gtgcctagtt gctggaaggt ttcgtcgcgg
     5821 gaccacaggc cgcggagcca ttgggtgatc atcggggcgg cgagtgtgca gtgttcgggg
     5881 atgccgcggt agaccgaggt gttcaggatt ttcaggggga gcttgacctg gtagcgcgaa
     5941 gggttcgaga tgttgaccat cgtgcggatc gactgggtcg ggaggtactc gtcggggctc
     6001 tcccccagca ccacgatctc cccggtggcg agttcgcggg cccactgggt gcggatgacg
     6061 tggtccagct gccacgggtg gcacgggagc cagacgtacg cgtccgggtc gtccagctgc
     6121 gcgcggaacg ccgctatggt ctccgggtcc agctccctcg agatgaccga gtgttccgag
     6181 aggtccggcg taccgcggaa ttcggcgaga cctcgtcgta cggcgagcca gacgaggtgc
     6241 agcggcgtac gggcttctgg ggcgtactgc tcgctgtcgg cggctgagaa gcccaggcga
     6301 cccttattgg cgaccaggag cgggtgcccg gtcaggtgtc cttccagccg cgtgtggtgc
     6361 agctcaagca actcagcagc gggcagcgcc gtagaggcca tccgtacgtc ggccgcgagc
     6421 gtgctcgtca gctcggcgac gtacccggcc acagtggacc cgtcgacccc tagtacgtcg
     6481 gcagcgtcga cgaagaaccg gatcgggtcg gtggcgatct cactctcgtc gttgccgaga
     6541 atgccggccg tggtacgtcg gatcgacgtc ggatcgaccc gccaactgcc gaagccacca
     6601 cgcgtcgcct cgaacacgta ggagaccgcc ccgagctcca gacggttgtc gacgggctcc
     6661 agcagccctt ccgtgcagaa ctgggagatc agcttcgcca gcaactccga cgagcactgg
     6721 gtccagacac tcatccaggg atcgcaaacg tcgtgtacgc ggtggacttg ggcagccgga
     6781 acacctctcg gccggccacg ctgttcagga tggtcgcgtt gcggatcgct ccgatgccga
     6841 ggtccggtgc cgcgacgccg tggctgtgca ggtcggcgtt cgcgacgaag atccgcccct
     6901 ccaaggcccc tcgcacgctg tggtcgcggt tgatgatcca gcgcccggca gcgtcgtgat
     6961 cgatctgcga ctgcagcgac tccaggaacg gcagtgaacg gttccggtag ccagttgcgg
     7021 cgacgacagc gccggtcatg tgctggaagg tcttgccgct gtcggcgtgg agcatcgtca
     7081 actcgagacc gtcggcacga gcgactgcgg acacgacgcc gactcctacc tgcagctcga
     7141 ccggagcggc gctcaggtcc cgcgagtaaa ggatgtcgtg gatgtcctcc agggtctccg
     7201 acgaaatgcc cttgtagtgc cgccactggt ccttcaccag ttggtcacgc acgggctcgt
     7261 ccagagcgtg gaagtagtcg acgtacgacg gtgtcgtcat ctccagcaca agcttcgagt
     7321 agtccagggg tgtgaacgcc gccgtgcgtg tcagccagga gactgccgga gcatcggagc
     7381 ggagcaggtc caagaagcac tcagcgcccg actgtcccga gccgaccacc gtcacccgac
     7441 ctgtgcgcag cagatcgtcc ctgcggaaca ggtagtcggc agagtgtgcg aatcgttccg
     7501 tagggagccc tgccagcgcg gcaggtacga acggctcggt gccgacgccg accaccaggt
     7561 gccgagcctc gaactgctcg acgctgtcac cgcgctccac ggtcagctca aacgatgtac
     7621 cgttccacac cgcttcccgc acgtggtgac cgaagtgcaa tgagtccagc tgtgccgcac
     7681 accaccgcag gtacgtttcg tactcccgcc gcgtcggatg gaacttctcc cgcacgtaga
     7741 actgatacag ccggtcgttg tccttcaagt acgacagaaa cgacaggtgg tgcgccggct
     7801 cgaccaacga caccagatcc gccaggaacg acacctgcag catcgcgtcc tcgaacatca
     7861 gcccgcgatg ccaggtgaac tcaggccggc tgtcgagcac agccagctgt acgtcgtcca
     7921 cgccgtccgc cagtgcggcc agtccgaggt tgaacggccc gcagccgatc gcaatcacgt
     7981 cgtacatgtc atgcctccct gcacggcccg ggtacggacc atcagtagtg ctgtcttctc
     8041 gggtagctgt agctgcccgt gctggacgaa tccggccgcg gcgaacgcgc ggaccgaagg
     8101 ggtgttctcg atatccggtt cggcgaccac ctgggcacag gccggctccg cgcgcagcac
     8161 ctcgtcgacg agccatcgca ggagccgccg cccgaggccc tggccgacgc gcgcgatgtc
     8221 accgatcgcc acgtgcacgc ccctgtcctc ctcgccgtac gcgtagtact ccgcaaggcg
     8281 gtcgtgccgg acccggtaca actcgacgta cgcgaactcc tccgcgtccg ccgcgaccag
     8341 gtacggcgtg gagtgctccc ccgccgcctg ttgctcgatc tcctgcgccc agcgctccac
     8401 cgaccagccc tgatgccacc agcgccggat gtgcggctgc gccatccaca gggcgatccg
     8461 cggggcgtcg gacgggcctg ccggccgcag gtcgaatgag gtcacaacag cgggttaggg
     8521 atgtcgaggt agacggactg tgcgtccagt ggcgccacta cctcgtcaat gccccgcagc
     8581 cgggtcagca tgttcgcctt gcacggcagc gtcttcgctt cgagccagcg ccgcgccagc
     8641 cgatccccag aaggtccagc agccttgagc agcggcagag cgagtgtcag ccgctcgcgc
     8701 accacaccga gcagctcacc ctcgtccgcg atcccgtccg ccgccagaca gcccaccacg
     8761 gccagcgcct ggttgtgcag caggtagtag gtcagtcgat cgtcgacaat cgggtcgtcg
     8821 acaaccgcca acgtcgagtc gcgcaggccg gtgattgtca acaatccacg caggtacgac
     8881 gaggcgaggt agtacccctg gttgtcccgg tacgcaccac ccttgatccg ccccgcgccg
     8941 tccagccgca ccagcgtgtt ctgctgatgc gcctcgagcc cgatgcccgt ctcggcgtac
     9001 aggtgcagca tcgggatcag cacgttgtcg atgtacgccg ccgtccagcc caacggatcc
     9061 tcggcggcaa aagcactcaa ccggctcaca ccgccaggac gtggcgcgac gagccctgcc
     9121 aagcaggcgt agctgttgac gtccgccgga acctctcgaa cggcgacgtc caggccggtc
     9181 aacaaaggcc caccctcgtc aagagccacc caggccgggt cgcgaacgat ggtgaagcgc
     9241 gggtgcgcgg tcgccgtccc cgcgttgtac gccgcgtcga gcaatcgatt gatctccagc
     9301 ccgcgccgca gctcggtcgg tgtcgactcc cgccgcgagt tcgtgatccg cagaccgagc
     9361 gagagtttca gcatcaccgg caggtccggg tgaaacacgg tccgcaagct ggacgtcggg
     9421 taccactggg caccgccggg tcccagtgcc ttcacacgac cggccgagat cagcgaggcg
     9481 acgcgcggac gctgcgccac cgctgccgcc tgccacggat gggccgggat cagcacccgg
     9541 cccggcgacg gggtgatacc ggccagcgcg cccatcagct gcacagcgtc cagtccctgc
     9601 agcgagggcg cgccggccac ctggtccgac gacaccagtt cggcgtcggc ttcgaaccag
     9661 tgcactgcga aacggccacc gagctccggc gagtacgccg ccagctcgtc accgctcagt
     9721 ccgtcccggc tcttcggcgc cgggtggttc aggtgcccga acagcagcgc ctgttcgagt
     9781 tcgaggaaac gccccgggcc gcgctgcccg tcggccagct cgacgaagag cgcgacgttg
     9841 cgcaccgact ccgccgtccg cgccgcgagg tcgtcgatct cggccggatc cgcgtccgcg
     9901 gacagcaacc gcacgagctc ctcgggttcg gcgggtacgc cgtccacctg gacgtcggtg
     9961 aactggtgca gcccggtccg cgacgcatgc tccacccgcg ccgtcaccgt cgagccgccg
    10021 gcctccaggg tcagcggccc gaccgcgacc ggcacggacg actcccgggt gtagcaccgc
    10081 aggatcgcgt tcagatgcgc gtctgccgca gtatcagccg cactatcagc cgcactagtc
    10141 acgccgctcc ttcgccggtc aggacgtcga ggccggtggc cacgacctgg tcgagcaggt
    10201 cctcgatgtc cgtcgcggtg gcgttcgggt tcagcagcgt cagcttcaac gcgaccgccg
    10261 ccgggcggcc gccgcgggcc ggcagcttgg tccggccgat cagcacccgc ccggaggtca
    10321 gcaaccggcg ccggacctcg ccctggaccg cgtccagtcc ggacgcgtcc aggccctgcc
    10381 ccgcgacccg gaacagcacc gtggtcaggg tcaccggcgc cagcaactcg aggttgctgt
    10441 cggcaacgac ccgggccgcg gcggcgtgcg cgagctcgtg acaggtgtcg accatcgttc
    10501 ccagtccggc ccgtccgtat gccgtcagcg tggtggcaac cttcaccgcg tccggccggc
    10561 gcgtggtctg caggctgcgg ccgagcagcc cgtccagccc ggagtcgatg tcgtcggccg
    10621 ggttcaggta gtccaccgag cggtcgaacg ccgcgaaccg gctccggtcc gccaccagca
    10681 gcacgctggt cgcggccggc tgccagccga tcttgtgcag gtccagcgtc accgagtccg
    10741 ccagcggtac gtcggcgagc agcggcgcca gccgctccga gaacagcgcc ccgaacccgt
    10801 acgccgcgtc gacgtgcagc caggcgccgt actgccgggc cagcgcggcg atcggcgcga
    10861 tcgggtccac cgatccgaag tccgtcgtac cggcggtcgc gaccaccgcc accggcgtgc
    10921 ggccggacct cgccaactcc tcggccagga catcggtccg catccggaag ttgtcgtccg
    10981 aggggatcgt gatcgcggcc tgctcaccga gcccgagggc ggcgcaggct cgctggaccg
    11041 agaagtgggc gagctcggag cagaacacga ccggccggtc gaagccctgc agaccgttcc
    11101 gccgaacgtc gatccccgcg gcggcggccg cgctgtcgcg ggcgatcagg atcgcgagca
    11161 ggttcgagat cgagccgccg ggggtgagta cgccgtccgc ctgcggaccg aacccggcca
    11221 gcgacgccag cgcgcggacg acccactgct cgatcgcgag cgtcgcggga ccggaatcgt
    11281 aggtgtccat cgaggcgttc gaggccgacg ccagcgcgtc cgcgtcgacc gcgacctgca
    11341 ggaccggcgg ctgcaggtgc gccgcggcgt gcgggtggct caggtcgatc ccgtgctcgt
    11401 cgagcagacc cgcgatcagg tcgagcgcgg ccgactcccc caccccggtc gacgggatcc
    11461 gcggctcccc caggacctcg gcggcgcgcc gcagtaccgc tcccggcgaa ccgtgcggca
    11521 acggtccgcg ctcacggtcc gagaccgtcg aggccagcgg ccagcgagcg gcgaacggat
    11581 cgcgaacagg tgcgggcagc gcggtgagac gcgcgggctg cgacat
//
