BGC0002697: clipibicyclene biosynthetic gene cluster from Streptomyces cattleya NRRL 8057 = DSM 46488
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Location: 3,428,542 - 3,470,332 nt. (total: 41,791 nt).
This entry is originally from NCBI GenBank CP003219.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002697
Short description clipibicyclene biosynthetic gene cluster from Streptomyces cattleya NRRL 8057 = DSM 46488
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
CP003219.1
3428542 - 3470332
via Heterologous expression
Compounds
  • clipibicyclene
  • azabicyclene B
  • azabicyclene C
  • azabicyclene D
Species Streptomyces cattleya NRRL 8057 = DSM 46488 [taxonomy]
References
Chemical products information
clipibicyclene Evidence:
(no structure information available)
azabicyclene B Evidence:
(no structure information available)
azabicyclene C Evidence:
(no structure information available)
azabicyclene D Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SCATT_32550
  • AEW95626.1
 3428542 - 3428892 (-) hypothetical protein
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    • SCATT_32560
    • AEW95627.1
    		 3428912 - 3429742 (-) methylthioadenosine phosphorylase
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      • SCATT_32570
      • AEW95628.1
      		 3429739 - 3430479 (-) 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
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        • SCATT_32580
        • AEW95629.1
        		 3430476 - 3431054 (-) putative oxidoreductase
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          • SCATT_32590
          • AEW95630.1
          		 3431095 - 3432738 (-) putative initiation factor eIF-2B alpha subunit-like protein
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            • SCATT_32600
            • AEW95631.1
            		 3432799 - 3433515 (-) hypothetical protein
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              • SCATT_32610
              • AEW95632.1
              		 3433588 - 3435066 (-) crotonyl CoA reductase
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                • SCATT_32620
                • AEW95633.1
                		 3435063 - 3436436 (-) cytochrome P450 protein
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                  • SCATT_32630
                  • AEW95634.1
                  		 3436761 - 3443915 (+) non-ribosomal peptide synthetase
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                    • SCATT_32640
                    • AEW95635.1
                    		 3443912 - 3445117 (+) FAD-dependent monooxygenase
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                      • SCATT_32650
                      • AEW95636.1
                      		 3445114 - 3446484 (+) monooxygenase, FAD-binding protein
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                        • SCATT_32660
                        • AEW95637.1
                        		 3446556 - 3447422 (+) hypothetical protein
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                          • SCATT_32670
                          • AEW95638.1
                          		 3447466 - 3447918 (+) hypothetical protein
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                            • SCATT_32680
                            • AEW95639.1
                            		 3448016 - 3465868 (+) type I polyketide synthase
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                              • SCATT_32690
                              • AEW95640.1
                              		 3465930 - 3466703 (-) hypothetical protein
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                                • SCATT_32700
                                • AEW95641.1
                                		 3467207 - 3467854 (+) ATP-dependent Clp protease proteolytic subunit 1
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                                  • SCATT_32710
                                  • AEW95642.1
                                  		 3468154 - 3468870 (+) ATP-dependent Clp protease proteolytic subunit
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                                    • SCATT_32720
                                    • AEW95643.1
                                    		 3468863 - 3470332 (+) transmembrane efflux protein
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                                      Biosynthesis information

                                      Biosynthetic modules

                                      Name
                                      Unk01
                                      Type
                                      nrps-type1
                                      Genes
                                      SCATT_32630
                                      Substrates
                                      serine (evidence: Structure-based inference, Homology)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk02
                                      Type
                                      nrps-type1
                                      Genes
                                      SCATT_32630
                                      Substrates
                                      azetidine-2-carboxylic acid (evidence: Structure-based inference, Homology)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Annotation changelog

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-10-07
                                      Update chemical activity to schema version 2.11
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Entry added
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Updated bioactivity data
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Added NRP substrate specificities
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      Detailed domain annotation
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