LOCUS       BGC0002698             12831 bp    DNA     linear   CON 22-MAR-2023
DEFINITION  Pseudophaeobacter arcticus DSM 23566
            Phaar_neu_scaffold_2516677464.1, whole genome shotgun sequence.
ACCESSION   BGC0002698
VERSION     BGC0002698
KEYWORDS    .
SOURCE      Pseudophaeobacter arcticus DSM 23566
  ORGANISM  Pseudophaeobacter arcticus DSM 23566
            Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
            Paracoccaceae; Pseudophaeobacter.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            KI421507.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 404176
            Source DNA and Organism available from Hans-Peter  Klenk
            (hpk@dsmz.de)
            Source DNA available from Hans-Peter  Klenk (hpk@dsmz.de)
            Organism available from Hans-Peter  Klenk (hpk@dsmz.de)
            Contacts: Hans-Peter  Klenk (hpk@dsmz.de)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 18:14:33
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 626502
            Orig. end    :: 639333
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..12831
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="ribosomal"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..12831
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1285..3429
                     /locus_tag="ARCT_RS0107000"
     CDS             1285..3429
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0005524 - ATP binding [Evidence IEA];
                     GO:0008233 - peptidase activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA];
                     GO:0055085 - transmembrane transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 255.2; E-value:
                     2.2e-77)"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR03796.1"
                     /locus_tag="ARCT_RS0107000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_027239422.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.6e-37, bitscore:
                     115.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGAKTPTILQIEAEECGAASLAMVLAFHGRHIPLEDLRIECGVS
                     RDGATAANVLKGARRHGLTASAKRLELPRLAEIPLPAIIFVNMNHFVVLEAVSAQRYRI
                     NDPAAGRRIVEHEAFDEMFTGITLLLEPGEAFERRPGPPGKLSSLLGYLEWDRTATQLI
                     LLCGITLIVPGLAIPAFSKAFVDDILMDGQDDWLFWFAVMMLAVIVLQTGLMALRSLLS
                     AKLEAKLALSLNARLAWRLLRLPLPFFQQRFSGALAGRGQMAARVAQLAGKSLVAATLE
                     GITLIFFLAVMALYSLKMAAAVGVLVLGSGVLILVVQQRMDQLSIKTMIEFMKLTGKTM
                     VGVQTIESIKSSGTEGKYFEGWAGTHANVVNGQAELTLRQSVLQVTPGFVSFFGKALTL
                     VIGGLEVMAGELTVGSLVAFQALLAAMDRPFQGLMANVQELQQVQGPLNQLRDITGSAE
                     AGEFSQRRNQVGPGEASRLNGAISLSDVSFGYSRLSPPLIANLDLEVAPGQRIALVGGS
                     GSGKSTLAKLITGAYSTWSGHIAFEGTSIEDLPRAVLRNSLAVVDQNIVLFEGSFGDNI
                     RLWDETISDEQVIAAAQAAEIHAFIAGTENGYDTQVEEGGRNMSGGQRQRLEIARALAR
                     DGSILVLDEATSALDPIVEAKVMQNIARLGITCVIVAHRLSTIRDCDQILVLDHGSVVQ
                     RGTHQGLRDVEGPYQRMIAA"
     gene            3426..6224
                     /locus_tag="ARCT_RS0107005"
     CDS             3426..6224
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 256.7; E-value:
                     7.4e-78)"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.2"
                     /locus_tag="ARCT_RS0107005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_027239423.1"
                     /transl_table=11
                     /translation="MSAQPQAAAQRPLHRADQDMVAYDDGAHVSLQGANRCFLIKNGRL
                     DLAIVCGDQSQVIAEMVEGEIILGLEGRIGLSGRARGDLRLCPIELSVYCSPDADPEQR
                     LHRALSLDIWLARLNNIAQEYQQGRAPTDQAVVAQGITWVKGPDGAEALPRPHFPQDGS
                     PNSVFARDTEALLARPRAAAAIAAANGHLAQAIAAGGQSKSEALIRRRAQQVTQDAARL
                     DRAFGQLSASLSATGAAAQQGDSGAQAAAGFSQIAHLAKRVGLGLSAVDNSKGLTGRDY
                     ICALCEANNIRYRSITLTEKWWRKDCGDFVAFDGDGQVLTVMRETRSYVVQDANGEKRR
                     FCPEMAATWEGQGLFLYWPLPDQPVTGWDLIGRVFRICASDLWTVFAVSLAMSLLALVL
                     PIGAGILVGKIIPQESQALLVQLGVILALVAMVQFAIGIISQIAAARIETRATLWIQGS
                     VMDRILRLPTGFFRSYSSGELTQRALAISRLERLVTNGMITGVLSGLFSFLSFGLMFHF
                     APGLVLPALGAAAVFITIAAFLGRAETAAARSQILTSGPVIARMMDIAQGIEKLRFAAA
                     EAPAFERWTQAFQLQQSAAYREKRMAALMETFSGSFLATATLMVFVVIGLRGSENEFST
                     ASLVSFLTCFASFMTGLGHLTRTATQLASFKPIYDFAAPILQAVPENSQGGTDPGALLG
                     EFSLTNLRFAYKDQGPMILDGLSLTIGAGEYVALVGDSGCGKSTLLRLLMGFETPKSGS
                     VSLDKIDLRNIDKRLMRRQFGVVMQDAKLLPGSIYDNIVGTNFGMPMEQVSRAIRQVGL
                     ADDIQQMPMGLQTGVVESSGGLSGGQVQRIMLARAIAASPRVLLLDEATSALDNRTQSI
                     VTETLDGMTATRIVVAHRLSTVVKADKIIVLDHGQVVEVGDYDSLMALEGKFASLAQRQ
                     LV"
     gene            6419..6703
                     /locus_tag="ARCT_RS25590"
     CDS             6419..6703
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ARCT_RS25590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="NHLP leader peptide family RiPP precursor"
                     /protein_id="WP_036784545.1"
                     /transl_table=11
                     /translation="MSNWTEEDQHTAISALMERCASDANFYQSALADPAAAIKTVSGKA
                     LPEGFNLRLVANEGADLTLVLPDPVSEDLSDADLEAVAGGGRSCTVTIM"
     gene            6808..7788
                     /locus_tag="ARCT_RS0107015"
     CDS             6808..7788
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025054.2"
                     /locus_tag="ARCT_RS0107015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_161631300.1"
                     /transl_table=11
                     /translation="MTVPFSTPAVSPCPPYSIQPIDPWLAQSAAAVVFPHFAKHLNGTD
                     PAIIRLAAVAGADSATKTRVLGAVLVEIGQVEIGQVDIAKTSATVLSLAVTPEFRRNGI
                     ARALLERALEQARIQGAKRACLSFVSRMPQVTALKALLHSAGWSEPAPRILFAETAPLQ
                     VLQQAWAQRVLHRGPRNATAFDWSDLTPEDRSYIEVETAAGRYPQDVSPFWDEGNIAPI
                     SLGLRAADGRVVGWLACHFVPQRSGTIRFSRSFCHADPAFRGNGAWVMAAALERHVNSS
                     LHQSHPTVLFDVDARNKAMMTVYRRRIEPYIDTSYQSFVVAKDLC"
     gene            7782..8753
                     /locus_tag="ARCT_RS0107020"
     CDS             7782..8753
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024054.2"
                     /locus_tag="ARCT_RS0107020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="UPF0489 family protein"
                     /protein_id="WP_027239425.1"
                     /transl_table=11
                     /translation="MLTMVHQPPLSQQTDRPNPIPVIGFEEHNEALIALAWARENALLG
                     KLPARLLHVDQHQDLVVPQLSRTIADTPLTVAAIKNLVETEISIASFVWAGVYLGLLDE
                     MFWLAPKPAIAGARPRSVLPSKYLWIATTDTQRREMITMVQRPEARGVGNDDRKSMALH
                     FVDTETQIPEQPGPEAAPWVLGIDLDYFSCNSMPDNGFRISVTQETYEQVSTNRHHPLR
                     LSPSHRIEARHDEQGYWLEYDMLPPRSADPLVRSTTEIEAEVDRLAAMLSRQAQAPALI
                     LIARSQISGFTPRHQCEFIEARVKDMLASVYPCTILEGSDLW"
     gene            8750..9607
                     /locus_tag="ARCT_RS0107025"
     CDS             8750..9607
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025007.2"
                     /locus_tag="ARCT_RS0107025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cupin-like domain-containing protein"
                     /protein_id="WP_161631301.1"
                     /transl_table=11
                     /translation="MSATSPNPQASEASAQGQSIARRNRLSASDLNRAFLSRGSSQPVV
                     LTGLTDGWPAMERWSFDHFAKTYGDERVIVTDFLGSKNLHKVGFGRYLDYVRDPSLDLL
                     PGKQAKTPWYSPYWSPFVDHPELAADFDVSEVVENWMPDASAIEASDGSSEALMAQWVL
                     RGFSWLFIGPAGTYTPRHLDTLNTHAWNTQICGRKRFDLWAPGRPAQDETPDLQVVLEP
                     GETLIIPMGWAHAVGALEASISLTGNFFNATNSAAFFRTIYTQPEVWQAKARLVPALKA
                     QLAP"
     gene            9604..12831
                     /gene="lanM"
                     /locus_tag="ARCT_RS0107030"
     CDS             9604..12831
                     /GO_process="GO:0018081 - peptide cross-linking via
                     lanthionine or 3-methyl-lanthionine [Evidence IEA];
                     GO:0018193 - peptidyl-amino acid modification [Evidence
                     IEA]; GO:0009403 - toxin biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     560.3; E-value: 1.4e-169)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="ARCT_RS0107030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_027239427.1"
                     /sec_met_domain="DUF4135 (E-value: 4e-68, bitscore: 219.3,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.5e-29, bitscore:
                     91.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAQPAGICDGAVGLVQQVAEIVARAQTLEERLARSGLSDQPWP
                     QHQQAEMVQSWRQICGQGDPGDFRKRLAWSGLTPARLEAYLGDPPAIPRSQWPDWAEVL
                     LDVLSTPRADARASANPATHSAHPFAAILAGFSGYAAQHLQTVYDDISKALGCDSRARL
                     QDGLLRRLCDVAVQALMAEFQIFRRARLAGTMVLPGAHQAYDAFVTSLQDRAGLLGLFQ
                     KYPVLARLLATVLQQWVGFVRTFRDRLLADLPLLEQAFGFGGSALLELAGSDPHQGGQV
                     CVKLVPQAGPAVFYKPKPLQPELVFEAFQAHLAALLGRPMRCRGETLDRGLYGWSKQVV
                     PAACRDAAEVASFFRASGHLLFGQYLLGGADIHCDNLIAAGAVPVIIDQECLMTNWPAP
                     SGDQVPAGVAAVRAMVFETVVRTSMLPEWNDAIDGWPLDISAFGGTGGPEKRTPELMVL
                     HMNSDLMRLVRRVTPAERGMAHLPRYGGNMIDPADHVDDILQGFSEAYQALRRAPELPA
                     GLVKTLQSVRARVVLRQSRAYGERLTRLCAPANLRNGFAAQLSMESLFQSLLQDPATAD
                     SLVPVVKSEFAQLMKMDVPVLHAQANGRAIQLPCKSEVREVFPASAMETLKARIARLGD
                     KDLALQRQKILTSFACHQRLGADCSAWVQHKGQRPLANDMLPAADQPSAAVLERMGDDL
                     LAQAIRGTEGSLAWHAPVYKENIGAWRMSPLRERVFDGALGIALFLAALTRHSGKKHYL
                     QAGLNGISNLLESADRAATVRMLMAPGLGCGTGVGSAIYGLVQLARISGQDHLADVARD
                     VFYRVEDLRSDDTPRTAKQDYGLSTGLSGYLNACLVLDQHQPGDARVLRALQDCVAQIA
                     GAAVPDQAGGTHWPSPHSLSPHGPGPHGFAHGSAGVATVLLRAARHLQDERLLDLGRRG
                     LRFALRQEQEGDLSWKTGGMGLCIAVQEALTVSDAQDLDLQNWHERQMGALSHHSGLVL
                     DDLSFGEAARASVLQRSVDMCARPDLAADVRRAYRRLWGRADKGGFEFGWPAGVALPGF
                     FQGTAGIGYQLLRRDFDVTLPDVFAFS"
ORIGIN
        1 atgttgaccg tggttccccc ccttgggtgg ttggcctctc tgcttcttgt cgcaagcgtt
       61 tttgcatttt tgatttgggc tttggttgcg actgctccag tcaaggttga cggcagcggc
      121 attcttttga cggaggggga aattgtcgcg gcgcgggcac aggggaccgg catcgtggtc
      181 gtgcaaccgg tcaaggttgg tgaccgggtg caagcgggcg atttgcttgc acgcctggaa
      241 aatttcaaga tgcaagaagg catttcgcag gccaaggccg ctttggcccg gggcgaaacc
      301 atgcttgcgc aaatccgcga ggtgcaccaa aaatttgtgg cttcgctaga ggcggaactc
      361 gcggatgccg agaccttcca ccaggaccgg accagcaatt ttcgcgaccg cattgtgaga
      421 ttggccaaac tcagacaaga gcgtcaggtg ctttttgaca agggcttgat cgtcgagcaa
      481 aaattgctgg agacccttca ggctctggaa gacgcccgtc agaacctcag cgcggcgcag
      541 ttcgactttt cttcaacccg caccacggcg ttggcagata tccatgaatc ccaatccaat
      601 cttgccgccc atgaaaacca aatactcacg gatcgtgaaa ggctgaaaga gctgcaagca
      661 gactatcagc gcattgtcga gatccgggcc gcggccgcag gcattgtgac ggaaagcacc
      721 aaaagcatcg gtgatcaggt cagcgccaat gacatcctct ttgaaatcct gccagaggcg
      781 gttgccgcac ccgcaggtca gccagcgacc cctgcattgc tggcggttct ctatgtggac
      841 gccagcaatg cagccaggct ggagccgggt ggcgcagttc aggtggtgcc tgcatccgtt
      901 gaactggaac gcgatggatt tattcatggt cagatcattg aggcctcggt tctgccagcg
      961 acgcaggcgc agctgttaaa gcgtttgcag aacccggatt tggttgcggc actgtcggca
     1021 aatgggccgg ttcgggaggt tttggtaacc cttgcaggcg atgcgcgcac ggccagcggg
     1081 cttgcctggt ccacccagga cgggcctgcg tttcggatcc atccgggcac tttgacgacg
     1141 gccagttttg tggtcgaccg caagcgtatt gcaagctttg tgtttcccaa actggatgcg
     1201 cttctgcccg ctctggcagg acgtggcccg cccccagaaa cagtctcggt tgcgcagccc
     1261 aaagcccgga ttgggggctg agccatgaag ggtgccaaaa ctcccacgat cctgcagatc
     1321 gaagccgaag aatgtggcgc ggcctcgctc gccatggtct tggcctttca tggccgccat
     1381 attccgcttg aggacctgcg gattgaatgc ggcgtctccc gtgatggggc caccgcagcc
     1441 aatgtgttga agggcgcgcg ccgacatggg ctaacggcca gcgccaaacg gcttgagctg
     1501 ccgcgccttg ccgaaattcc cctgcctgcg atcatctttg tgaatatgaa ccattttgtg
     1561 gtgctggaag ccgtttcggc gcagcggtat cgcattaatg atcccgcagc cgggcggcgc
     1621 attgttgagc atgaggcgtt cgacgagatg ttcacgggca tcaccctgtt gctggaaccg
     1681 ggagaggcgt ttgaacgcag accaggccca cccgggaagc tgtcttcgct gcttgggtat
     1741 ctggaatggg accgcactgc gacccagctt atcctgctct gtgggatcac cctgatcgtg
     1801 cctgggctgg ctattcccgc tttcagcaag gcctttgtcg acgatatttt gatggatggg
     1861 caggacgact ggctattctg gtttgcagtc atgatgctgg cggtgattgt ccttcagacg
     1921 gggctgatgg ccctgcgcag tttgctgagc gccaaactgg aagcaaaact ggccctgtcg
     1981 ctgaatgcca ggcttgcctg gcgcttactg cggttgcccc ttcctttctt tcagcaaagg
     2041 ttttcagggg cgctggccgg gcgggggcag atggccgcac gggtggcgca actggccggg
     2101 aaaagcctgg ttgcggcgac gttggagggg atcaccctga tcttctttct cgcggtcatg
     2161 gcgctttaca gcctcaaaat ggcggcggca gtgggcgttt tggttctggg cagcggcgtg
     2221 ctgatcctgg tggtgcagca gcgcatggat cagctttcga tcaagacaat gatcgaattc
     2281 atgaagctga ccggcaagac catggtgggg gtgcagacga ttgaaagcat caagtcctcg
     2341 ggcaccgaag gcaaatattt tgaaggctgg gccggtaccc atgccaatgt ggtgaacgga
     2401 caggccgagc tgacccttcg gcaatcggtg ttgcaggtca cgccggggtt tgtgtccttc
     2461 tttggcaagg ccctgaccct ggtgatcggt gggcttgagg tcatggccgg ggagctgacg
     2521 gtgggatccc tggtggcctt ccaggccttg ctcgcggcga tggacaggcc gtttcagggg
     2581 ctgatggcca atgtacaaga gctgcaacaa gtgcagggac cactgaacca gctcagggat
     2641 attaccggca gcgcggaggc gggtgagttt tcgcagcggc gcaaccaggt ggggccaggg
     2701 gaggcatcgc ggttaaacgg agctatctca ttgtcagatg tgagttttgg ctacagccgc
     2761 ttgtcaccgc ctttgattgc caaccttgat cttgaggtcg ccccgggaca acgtattgcc
     2821 cttgtcggcg gctcggggag cggcaaatca accctggcca agctgattac aggcgcctat
     2881 tcgacctggt ccggccacat cgcctttgag gggacttcga tcgaagatct gccacgcgcg
     2941 gtcttgcgga actcccttgc cgttgttgac cagaatatcg tcctttttga aggcagcttt
     3001 ggcgacaaca tccgcctgtg ggatgaaacc atttccgacg agcaggtgat cgctgcggcg
     3061 caggcggctg aaatccatgc gttcattgcc ggtactgaaa acggttacga cacgcaggtc
     3121 gaagaaggcg ggcgcaatat gagcggtggc cagcgccagc ggctcgagat cgcccgggcg
     3181 ctggcgcgcg atggctccat cctggttctg gatgaggcca caagtgccct agaccccatc
     3241 gtcgaggcaa aggtgatgca aaatattgcc cggctgggga tcacctgtgt gatcgtggcc
     3301 cacaggttgt cgaccattcg tgattgcgat cagattctgg tgttggatca tggcagtgtt
     3361 gtgcaacggg gaacgcacca aggcctgcgc gatgtggagg gtccctatca gaggatgatc
     3421 gccgcatgag cgcacagccc caagccgctg cacagcgccc gctgcacagg gccgatcagg
     3481 acatggtggc gtacgacgac ggcgcgcatg tctctttgca gggggcaaac cggtgtttcc
     3541 tgatcaaaaa cgggcgtctg gatctcgcca tagtctgcgg tgaccagtca caggtcatag
     3601 cagagatggt tgagggcgag atcattctcg gtctggaggg caggattggg ctgtctggtc
     3661 gggcgcgcgg cgatctgcgg ctgtgcccga tagagctgtc tgtctattgc agcccggatg
     3721 cagatcccga gcaaagactg caccgcgcgc tgagccttga tatctggctg gcgcgtctca
     3781 acaatattgc gcaggaatat cagcagggga gggcgccgac agatcaggct gtggtggcgc
     3841 agggcattac ttgggtcaaa ggcccagatg gcgcagaggc gctcccgaga ccacattttc
     3901 cacaagatgg cagtccaaac tctgtgtttg cccgcgatac cgaggctctt ttggcaaggc
     3961 ccagggccgc cgctgccatt gcggcggcca atgggcacct ggcgcaggcc attgccgccg
     4021 ggggccaaag caaaagtgag gccttgatcc ggcggcgcgc gcagcaggta acacaggacg
     4081 cagcccgcct ggaccgtgct tttggacagc tgagcgcgtc cctgtcggcg acaggggcag
     4141 cagcacagca gggagatagc ggtgctcagg cggcagctgg gttcagccag attgcgcatc
     4201 tcgccaagcg ggtaggcctg ggcctgtctg cggttgacaa ttccaagggt ctgaccggac
     4261 gggactatat ttgcgccctg tgcgaggcca acaacattcg ctaccgctca atcacgctga
     4321 cggaaaaatg gtggcgcaag gactgcggtg actttgtcgc atttgatggc gacgggcagg
     4381 ttctcacggt tatgcgagag accagatcct atgtagtgca ggatgccaat ggggagaaac
     4441 ggcgtttttg tcccgagatg gcagcgactt gggaggggca ggggctgttt ctctattggc
     4501 cgcttccaga tcagcccgtc actggctggg atttgatcgg gcgggtgttt cgcatctgcg
     4561 cctcggatct ttggaccgtc tttgcggtca gcctggccat gagcctcttg gcactggtgc
     4621 tgccaattgg tgcgggcatt ctggttggca aaatcattcc gcaggaaagt caggcgcttt
     4681 tggtgcagct tggcgtgatc cttgccctgg ttgcgatggt gcaatttgcc atcggcatta
     4741 tttcccagat tgcggcagcc aggattgaaa cccgcgcgac gctttggatc cagggatccg
     4801 tcatggaccg gatattacgc ctgcccaccg ggttctttcg cagctactca tcgggggagc
     4861 tgacccagcg cgccctggcg atcagccgat tggagcggct ggtgaccaat ggcatgatta
     4921 ccggcgtcct gtcgggactg ttttcgttcc tgagctttgg cttgatgttt cattttgccc
     4981 ccggacttgt gctgcccgcg ctcggggcag cagccgtttt tatcaccatt gccgcctttc
     5041 tgggccgggc agaaacagct gccgcccgca gtcagattct gaccagcggg cccgttattg
     5101 cccgtatgat ggatattgcg cagggcattg aaaaactgcg ctttgccgcc gccgaggcgc
     5161 ctgcatttga acgctggaca caggcctttc agctgcaaca atcggcggcc taccgggaaa
     5221 agcgtatggc ggcattgatg gagaccttta gtggctcctt ccttgcgacg gccacattga
     5281 tggtctttgt ggtgattgga ctgcgcggca gtgaaaatga attctccacg gccagtctgg
     5341 tcagttttct gacatgtttt gccagcttca tgactgggct gggccatttg acccgcacgg
     5401 cgacgcagct ggcaagcttt aagccgatct atgactttgc agcccccatt ctgcaagctg
     5461 tccccgaaaa cagtcagggc ggtaccgatc ccggcgcgct cctgggggag ttctcgctca
     5521 ccaatctgcg ctttgcctac aaagaccagg ggccgatgat cctggatggg ctaagcctga
     5581 caatcggagc tggcgaatat gtggcgctgg tcggggactc gggctgcggg aaatcgaccc
     5641 tgctgcggct gcttatgggg tttgagactc caaagtcagg gtctgtcagc ctggacaaaa
     5701 tcgacctgcg aaatatcgac aaacgcttga tgcggcgaca gtttggtgtg gtcatgcagg
     5761 atgccaaact gctgcctggc tcaatctatg acaatatcgt cggcaccaat tttggcatgc
     5821 cgatggagca ggtgagcagg gccattcgtc aggtgggact agcagacgac attcagcaga
     5881 tgcccatggg gttacaaacc ggggttgttg aatcatctgg tggtctgtct ggtggccagg
     5941 ttcagcgcat catgctggcc cgcgccattg ctgccagccc cagggttctg ttgctggatg
     6001 aagcgacaag tgctttggac aaccggacac agtccattgt gaccgaaacg ctggacggga
     6061 tgacggcgac gcggattgtc gtggcgcatc ggctgtccac ggtggtgaaa gctgacaaga
     6121 tcatcgtgct ggatcatggc caggtggtag aggtcggaga ctatgacagc ctgatggcgc
     6181 tggagggcaa atttgcgtcc ctggcacagc gccagcttgt ctgattttgg cattctgcac
     6241 gaaataattg cgcaggatcc ctcaaaaagc acgcattcca acaggccctt tgaaactaat
     6301 taaccctttt cattttatcg tctcctcaca ataccatcgc gccttttgct ccggtgggcc
     6361 tatttgtcat gccacctttg ggcagggacc ttttaaaact tcacgtaagg aacttattat
     6421 gtcgaattgg accgaagaag atcaacatac tgccatctcc gctttgatgg agcgctgcgc
     6481 aagtgatgcg aatttctatc agagcgccct tgctgatcct gccgcagcaa tcaaaactgt
     6541 gtccggcaag gctctgcccg aaggtttcaa tctgcggctg gtggccaatg agggcgcaga
     6601 tctgactctg gtcctgcccg acccggtgag cgaagacctg tccgatgcgg atctggaagc
     6661 tgtcgctggt ggtggtcgca gctgcaccgt caccattatg taatccgcga cggatcaagc
     6721 gctccggctg gccgcgtcag cgcccggccg gatcacgcgc cgcgcctctg gctgaggccg
     6781 gcccagattt ttcctgaggg tcgttctgtg acagtcccgt tttccacgcc tgcagtgtcg
     6841 ccctgtccgc cctatagtat tcaacccatt gatccttggc tggcccaatc ggcggcggct
     6901 gtggtttttc cgcattttgc aaaacacctg aacggtacag atccggcaat catccgattg
     6961 gcggctgtcg caggcgcgga tagcgcaaca aaaacgcggg ttttgggagc cgttctggtt
     7021 gaaatcggcc aggttgaaat cggccaggtt gatatcgcca agaccagcgc cacggttctg
     7081 tcgctggctg tgaccccaga gtttcgtcgc aatggcatcg ccagggcgtt gctggaacgg
     7141 gctttggagc aggccagaat acagggggcc aaacgggcct gcctgtcgtt tgtgtcccgg
     7201 atgccccagg tcaccgcatt gaaagctttg ctgcacagtg caggctggtc ggaaccggcc
     7261 ccacggatac tgtttgcaga aacggcgccg ctgcaggtgt tgcaacaggc ctgggcgcag
     7321 cgggtgctgc accggggacc gcgcaatgcc accgcctttg actggagcga cctgacgcca
     7381 gaagaccgca gctatattga ggttgaaaca gcagccgggc gctacccgca ggatgtgtcc
     7441 cctttctggg atgagggcaa tatcgccccg atcagcctgg gcctgcgggc tgcggatggg
     7501 cgcgtggtgg gctggctggc ctgccatttt gtaccgcagc ggtccggcac catccggttt
     7561 agccgcagct tttgccatgc ggatcccgcc tttcgcggca acggcgcctg ggtcatggca
     7621 gcggcgctgg agcgtcacgt aaacagcagc ctgcaccaaa gccacccgac tgttcttttt
     7681 gatgtggatg cgcgcaacaa ggcgatgatg actgtctata gacgccggat agagccctac
     7741 atcgacacct catatcaaag ttttgttgtg gcaaaggatt tatgctgacc atggtgcacc
     7801 agccccccct ttcgcagcag acagacaggc caaaccccat cccggtgatc gggtttgaag
     7861 agcacaacga ggccctgatt gcgcttgcct gggcgcgcga gaatgccctg ctgggcaagc
     7921 tgcctgcgcg ccttttgcat gtagatcaac atcaggatct ggtggtgccg cagcttagcc
     7981 ggacgattgc cgatacgccg ctgacggttg cggctatcaa gaacctggtg gagaccgaga
     8041 tctctatcgc gagcttcgtc tgggccgggg tctatctggg acttctggat gagatgttct
     8101 ggcttgcgcc caaacccgcc attgccggcg cgcggccgcg ctcggtcctg cccagcaagt
     8161 acctgtggat tgccaccacg gatacgcagc gacgtgagat gattacgatg gtgcagcgcc
     8221 ccgaagcccg tggcgtgggc aatgacgacc gcaaatctat ggcgttgcat tttgtcgata
     8281 ccgagaccca gatccccgaa cagcccggcc cggaggccgc tccttgggtg ctggggattg
     8341 atctggatta tttctcctgc aacagcatgc cggacaacgg gtttcgcatc agtgtcaccc
     8401 aggaaaccta cgagcaggtc tcaaccaacc gccaccaccc gctgcgcctg tcgccgtcgc
     8461 accggattga ggcccgtcac gatgaacagg gctactggct ggaatatgac atgttgcccc
     8521 cccgcagcgc tgatccgctt gtgcgcagca ccacagagat cgaggccgag gtcgacaggc
     8581 tggcggcgat gttgtcgcgg caagcgcagg cccccgcgtt gatcctgatc gcccgctcac
     8641 agatcagcgg atttaccccc cgccaccaat gtgaattcat cgaggcgcgg gtcaaggaca
     8701 tgctggcctc ggtctatccc tgcacaattc tggaaggatc cgacctatgg tgagtgctac
     8761 ttcacccaac ccgcaggcgt cagaggccag cgcgcagggg caaagcatcg cgcgtcgcaa
     8821 tcgcctttcg gcctctgatt tgaaccgcgc cttcctcagc cgtggcagct ctcagcctgt
     8881 ggtactgacg ggattaaccg atggctggcc cgcgatggag cgctggagct ttgaccattt
     8941 tgccaaaacc tatggggatg agcgggtcat cgtgaccgat tttctgggct caaagaacct
     9001 ccacaaggtc ggctttggcc gctatctgga ctatgtgcgg gatccttcgc tggatcttct
     9061 gccgggcaag caggccaaga ccccctggta ttccccctat tggtcacctt ttgtggatca
     9121 cccggagcta gcagccgatt ttgatgtctc tgaggtggta gagaactgga tgccggatgc
     9181 cagcgcgatt gaggcctctg acgggtccag cgaggcgctg atggcgcagt gggtgctgcg
     9241 cgggttttcc tggctgttca tcggtccggc cgggacctat acgccccggc atctggacac
     9301 gctgaacacc catgcctgga acacccagat ttgcgggcgc aaacggtttg atctctgggc
     9361 cccaggtcgc ccggcacagg acgaaacacc ggatcttcag gtggtgcttg aaccgggcga
     9421 gacactcatt attccaatgg ggtgggccca tgccgtgggg gcgcttgagg cgtcgatcag
     9481 tctcaccggg aatttcttca acgccaccaa tagcgctgcg tttttccgca ccatctacac
     9541 ccagccagag gtctggcagg ccaaggcgcg tcttgttccg gcgctaaagg cgcagctggc
     9601 accatgactg cggcccagcc tgcagggatc tgcgacgggg ctgtgggcct tgtgcagcag
     9661 gtggcggaaa tagtcgcccg cgcccagacc ctggaagagc ggctggccag atctgggctg
     9721 tcggatcaac cctggccaca gcatcagcag gccgaaatgg tccaaagctg gcggcagatc
     9781 tgcggccagg gagatccggg ggatttccgt aaacgcctgg cgtggtccgg tctcacccca
     9841 gcgcggctgg aggcctatct gggtgatcca ccagccatcc cgcgcagcca gtggccggat
     9901 tgggcagagg tgctgctcga tgtgttatcg acgccccgcg ctgatgcacg tgccagcgca
     9961 aatcctgcca cccattcagc ccatcccttt gccgcgattc tggcaggatt ttccggctat
    10021 gccgcgcagc atttgcaaac cgtctatgat gatatctcca aggcgctggg ctgcgacagc
    10081 cgtgcccgcc tgcaagatgg gctgctccgc cgcctatgcg atgtggccgt gcaggcattg
    10141 atggccgagt ttcagatctt tcgcagggcg cggcttgccg ggaccatggt gctgccgggc
    10201 gcgcatcagg cctatgatgc ctttgttaca tccctgcagg atcgggcggg tttgctgggg
    10261 ctttttcaga aatatcctgt gcttgcgcgg cttctggcca cggtcctgca acaatgggtt
    10321 ggatttgttc gcacattccg tgaccgactg ttggccgatc tgccgctgct ggagcaggca
    10381 tttggctttg gcgggtctgc cctgctggaa ctggcgggct ctgatccgca tcaggggggc
    10441 caagtctgtg tgaaactggt gccgcaggcc gggcctgctg tgttctacaa accaaaaccg
    10501 ctgcagccgg agctggtgtt tgaagcgttc caagcacatc tggccgcgct gcttggccgt
    10561 cctatgcgct gccgtgggga gaccctggat cgcggtctgt acggctggag caagcaggtc
    10621 gtgcccgccg cctgtcgcga tgcggcagaa gtagcctctt tctttcgcgc cagcgggcat
    10681 cttttgtttg gccagtacct gttgggtggc gcggatattc actgtgacaa cctgattgcg
    10741 gcgggggcgg tgccggtcat cattgatcag gaatgtctga tgaccaattg gccagcaccc
    10801 agtggtgatc aggtcccggc aggtgttgcc gctgtgcgtg cgatggtttt tgaaaccgtg
    10861 gtgcggacct ctatgttgcc ggagtggaat gacgccattg acgggtggcc gctcgacatc
    10921 agcgcatttg gcggcacagg tggtcccgaa aaacgaacgc cagagctgat ggttctgcac
    10981 atgaactcgg acctgatgcg gctggtgcgc agggtcacac ctgctgagcg gggcatggcc
    11041 catctgcccc gctatggcgg caatatgata gatccggctg atcacgttga tgatattttg
    11101 caagggtttt cagaagccta ccaagcactg cgccgcgcgc cggaattgcc tgccgggctg
    11161 gtcaaaaccc tgcagtctgt gcgcgcccgg gtggtgttgc ggcagagccg cgcctatggc
    11221 gagcggctga cacgcctgtg cgcgcctgcc aatctgcgca atggctttgc tgcgcaactc
    11281 tccatggaga gcctgtttca atcccttttg caggacccgg ccacggcgga cagcctggtg
    11341 cccgttgtca aaagcgagtt tgcccaactg atgaagatgg acgtgccggt gctgcacgcc
    11401 caggccaatg gccgcgccat ccagctgcca tgcaaaagtg aggttcggga ggtatttcca
    11461 gcctccgcca tggagaccct caaagcgcgg attgcccggt tgggcgacaa ggacctggcg
    11521 ctgcaaaggc aaaaaatcct caccagtttt gcctgtcacc aacggttggg ggcggattgc
    11581 tcggcttggg tgcaacacaa agggcaacgc cccctggcaa atgacatgct gcccgccgcg
    11641 gatcagcctt cagctgcagt gcttgaacgc atgggggatg atctgctggc acaggccatt
    11701 cgtggcacgg agggctctct tgcctggcat gcgccagtgt ataaggaaaa catcggcgcc
    11761 tggcgtatgt ccccgctgcg cgagcgggtg tttgatggcg cgcttggcat tgccttgttc
    11821 ctggcggctc tgacgcggca cagcggcaag aaacactatc tgcaagcggg gctgaatggg
    11881 atttcaaacc tgcttgagag tgcagatcgg gccgctacgg tgcgtatgct gatggccccg
    11941 gggctgggct gtggcaccgg agtggggtcg gcgatctacg gtctggtgca gcttgcgcgg
    12001 atcagcggcc aagatcacct ggccgatgtg gcacgggatg ttttctaccg ggttgaggat
    12061 ctccgcagcg acgacactcc ccgcaccgca aaacaggact acggcctgtc taccggcctg
    12121 tccggctatc tgaatgcctg tttggtgttg gaccagcatc aacccggcga tgcccgggtg
    12181 ctgcgggcac tgcaggactg tgtggcgcag attgccgggg cggcggtccc tgatcaggcg
    12241 ggaggcaccc attggccctc gcctcatagc ctgtcgcctc atggccctgg gccgcatggt
    12301 tttgcccatg gcagcgcagg ggtcgcaacg gtgctgctgc gcgcggcacg acacctgcag
    12361 gacgagcggc ttctggacct tggccgccgt ggcctccgct ttgctctgcg tcaggagcag
    12421 gagggggatc tcagctggaa aaccggtggc atggggcttt gtatcgcggt gcaggaggcc
    12481 ctgactgtat cggatgcaca ggatttggat ttgcagaact ggcatgagcg gcagatgggg
    12541 gctctcagcc atcactctgg gctcgtgctg gatgatctga gttttgggga ggccgcccgg
    12601 gcttcggtcc tgcagcgcag cgtcgatatg tgcgcccgcc ctgatttggc tgcggatgtc
    12661 aggcgggcct atcgtcggct atggggtcgt gcggacaaag ggggctttga gttcggctgg
    12721 cccgcggggg tagcactccc cggctttttc caaggcaccg ccgggatcgg atatcagttg
    12781 ttgcgtcgtg actttgatgt gacgctgccg gatgtctttg ccttctcata a
//
