BGC0002698 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002698 (Pseudophaeobacter arcticus DSM 23566)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	23,228	High	phaeornamide	ribosomal:RiPP

BGC0002698 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 23,228 nt. (total: 23,228 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 23,229
Label		BGC0002698

Tailoring functions

Lyases: cyclase

ARCT_RS0107030: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002698.2	1.00	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000551.5	0.55	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000590.5	0.51	ribosomal	microcin N	Escherichia coli
BGC0000554.4	0.51	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002699.2	0.47	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000504.5	0.45	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000519.4	0.45	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000501.3	0.44	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000500.5	0.44	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000496.5	0.42	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002698.2	1.00	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000551.5	0.55	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000590.5	0.51	ribosomal	microcin N	Escherichia coli
BGC0000554.4	0.51	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002699.2	0.47	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000504.5	0.45	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000519.4	0.45	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000501.3	0.44	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000500.5	0.44	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000496.5	0.42	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for ARCT_RS0107030

allorf_14049_14240

Leader:

MSLCNTICNITGTSRTWSGRYCSIAARVPSG

Core:

VNMGMMTWVPAIRVMALNHSRSAMWNIGAACR

Core with dehydrations:

VNMGMMDhbWVPAIRVMALNHDhaRDhaAMWNIGAACysR

antiSMASH-DB 4.0 matches for allorf_14049_14240

23.1%

NZ_KZ845663.1:

Lanthipeptides: allorf_205291_205461_lanthipeptide

NHSR----SAMWNIGAAC

N SR S +WN GA C

NQSRTNRISPLWNEGALC

allorf_14388_14576

Leader:

MCLCPERRRGRNPDLRRNFQGS

Core:

RRRGETASGRAKDADLCRRRHDARGHGKLRRPDRSRRACC

Core with dehydrations:

RRRGEDhbADhaGRAKDADLCysRRRHDARGHGKLRRPDRDhaRRACysCys

antiSMASH-DB 4.0 matches for allorf_14388_14576

25.0%

NZ_CM002330.1:

Lanthipeptides: allorf_5797326_5797457_lanthipeptide

RRRHDARGHGKLRRPDRS

R R AR HG L RP +S

RLREQARSHGDLCRPQQS

allorf_14698_14790

Leader:

MPQYSRTASKAGA

Core:

KCWTALPAWLAPCRALA

Core with dehydrations:

KCysWDhbALPAWLAPCysRALA

antiSMASH-DB 4.0 matches for allorf_14698_14790

31.8%

NZ_CP015219.1and 1 other:

NZ_CP015219.1 Lanthipeptides: A3Q40_RS20035_lanthipeptide

Lanthipeptides: A3Q40_RS20035_lanthipeptide

LPAWLAPCRALA

+PA PC ALA

VPATTVPCSALA

19.2%

NZ_HG964446.1:

Lanthipeptides: allorf_1112914_1113042_lanthipeptide

LPAWLAPC

LP +L PC

LPGFLTPC

allorf_15306_15398

Leader:

MSRERSLCGS

Core:

SRRSRGSGWSFPNLRRAWGC

Core with dehydrations:

DhaRRDhaRGDhaGWDhaFPNLRRAWGCys

antiSMASH-DB 4.0 matches for allorf_15306_15398

25.0%

NZ_JHEG04000001.1and 8 others:

NZ_JHEG04000001.1 Lanthipeptides: HC643_RS12615_lanthipeptideNZ_JHEG04000001.1 Lanthipeptides: HC643_RS12610_lanthipeptideNZ_JHEG04000001.1 Lanthipeptides: HC643_RS12605_lanthipeptideNZ_JHEG04000001.1 Lanthipeptides: HC643_RS12600_lanthipeptideNZ_JHEG04000001.1 Lanthipeptides: HC643_RS12595_lanthipeptideNZ_JHEG04000001.1 Lanthipeptides: HC643_RS12590_lanthipeptideNZ_JHEG04000001.1 Lanthipeptides: HC643_RS12585_lanthipeptideNZ_JHEG04000001.1 Lanthipeptides: HC643_RS12580_lanthipeptide

Lanthipeptides: HC643_RS12620_lanthipeptide

GWSFPNLRRAW

GWSF + AW

GWSFAKVCVAW

allorf_15423_15605

Leader:

MQSATKVEAG

Core:

PRAKTSRICSIPAPLANMVPWQWRLSAQNARWPSCSHVPKAMGSSVAPAQ

Core with dehydrations:

PRAKDhbDhaRICysDhaIPAPLANMVPWQWRLDhaAQNARWPDhaCysDhaHVPKAMGDhaDhaVAPAQ

antiSMASH-DB 4.0 matches for allorf_15423_15605

20.0%

NZ_BMMB01000007.1:

Lanthipeptides: allorf_023913_024077_lanthipeptide

SRICSIPAPLANMVPWQWRLSAQNARWPSC

SR I L + W W L R P+C

SREIQIQLWLTGPIHWMWGLQIHVVRSPTC

16.0%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: allorf_141930_142139_lanthipeptide

Lanthipeptides: allorf_141930_142139_lanthipeptide

CSIPAPLANMVPWQWRLSAQNARW

C + + L ++ P +WR + ARW

CPLGSALGSIAPCRWRRDLRYARW

16.0%

NZ_JABBWU010000018.1:

Lanthipeptides: allorf_001126_001335_lanthipeptide

SRICSIPAPLANMVPWQWRLS

++C +P PL + W RLS

DQLCCLPTPL--LAGWLLRLS

with 4 more sequence matches

14.0%

NZ_CP011112.1:

Lanthipeptides: allorf_0460321_0460527_lanthipeptide

SIPAPLANMVPWQ

++PAP+A+ VP+Q

AVPAPIAHRVPFQ

13.7%

NZ_LMHM01000001.1:

Lanthipeptides: allorf_737669_737890_lanthipeptide

RWPSCSHVPKAMG

RWP C H + MG

RWPPCPHRRRRMG

12.0%

NC_015953.1:

Lanthipeptides: allorf_2485079_2485273_lanthipeptide

WPSCSHVPKAMGSSVAPAQ

P+C + + G+ +APA+

GPACGTLRRRYGAGIAPAR

12.0%

NZ_WWGT01000021.1and 1 other:

NZ_WWGT01000021.1 Lanthipeptides: allorf_033513_033707_lanthipeptide

Lanthipeptides: allorf_033513_033707_lanthipeptide

PSCSHVPKAMGSSVAPAQ

P+C + + G+ +APA+

PACGTLRRRYGAGIAPAR

allorf_15801_15956

Leader:

MCPRFAISPPIGAPRLASSRGC

Core:

ALRGMRHCLACAMCELPPRTAGSGWAVRR

Core with dehydrations:

ALRGMRHCysLACysAMCysELPPRDhbAGDhaGWAVRR

antiSMASH-DB 4.0 matches for allorf_15801_15956

21.9%

NZ_CP084203.1:

Lanthipeptides: allorf_0587605_0587784_lanthipeptide

CELPPRTAGSGWAVR

C +PP G G A R

CPVPPADGGQGAAER

18.9%

NZ_JACHGN010000015.1:

Lanthipeptides: allorf_121771_121980_lanthipeptide

LACAMCELPPRTAGSGWAV

+ CA C PPR+ + +V

ILCASCTSPPRSQKASPSV

allorf_16408_16578

Leader:

MRHAGLYGG

Core:

ACDRGDRAGGPYFAPVPCRSAFCPAVGDRHSAQGLWSGGDGDGGWWF

Core with dehydrations:

ACysDRGDRAGGPYFAPVPCysRDhaAFCysPAVGDRHDhaAQGLWDhaGGDGDGGWWF

antiSMASH-DB 4.0 matches for allorf_16408_16578

23.4%

NZ_CP075170.1and 1 other:

NZ_CP075170.1 Lanthipeptides: KIK00_RS10035_lanthipeptide

Lanthipeptides: KIK00_RS10035_lanthipeptide

AVGDRHS-AQGLWSGGDGDGGWW

AV RH+ GL +GGDG W

AVSTRHNFTCGLCTGGDGTKDSW

12.8%

NZ_KB907258.1:

Lanthipeptides: G358_RS0114910_lanthipeptide

CRSAFCPAVGD

C S FCP+V +

CLSLFCPSVAE

MIBiG 4.0 matches for allorf_16408_16578

8.5%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

SAFCP

+AFCP

AAFCP

8.5%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

SAFCPAV

+AFCP

AAFCPTT

allorf_17091_17210

Leader:

MRSTSLVSVGG

Core:

FIKTISASCPMVSRGPSSRVSKIRQASI

Core with dehydrations:

FIKDhbIDhaADhaCysPMVDhaRGPDhaDhaRVDhaKIRQADhaI

antiSMASH-DB 4.0 matches for allorf_17091_17210

28.6%

NC_012470.1and 5 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06490_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09840_lanthipeptideNZ_JAEEGA010000010.1 Lanthipeptides: I6N95_RS15660_lanthipeptideNZ_JH792236.1 Lanthipeptides: IIM_RS26245_lanthipeptideNZ_JH792236.1 Lanthipeptides: IIM_RS26240_lanthipeptide

Lanthipeptides: SZO_RS04065_lanthipeptide

IKTISASCPMVS

IKTIS C M S

IKTISHECHMNS

25.0%

NZ_LT732526.1and 1 other:

NZ_LT732526.1 Lanthipeptides: BQ9856_RS23075_lanthipeptide

Lanthipeptides: BQ9856_RS23080_lanthipeptide

IKTISASCPM

IKTIS C M

IKTISHECAM

21.4%

NZ_MRCE01000007.1:

Lanthipeptides: allorf_233912_234007_lanthipeptide

FIKTISASCPMVSRGPSSRVS

F K + +CP+ PS ++

FGKILMVACPIYWLNPSLQID

with 3 more sequence matches

15.2%

NC_017621.1and 16 others:

NZ_CP039462.1 Lanthipeptides: E8M06_RS05390_lanthipeptideNZ_JABTZM010000032.1 Lanthipeptides: HRQ47_RS09675_lanthipeptideNZ_JAEVFQ010000010.1 Lanthipeptides: JNO64_RS06375_lanthipeptideNZ_JAFFHD010000003.1 Lanthipeptides: JN532_RS02075_lanthipeptideNZ_JAGFVG010000007.1 Lanthipeptides: J5581_RS04225_lanthipeptideNZ_JAIJZO010000001.1 Lanthipeptides: K5Q34_RS00965_lanthipeptideNZ_JAIMDS010000024.1 Lanthipeptides: K6V32_RS10650_lanthipeptideNZ_JAJUWV010000001.1 Lanthipeptides: LZF89_RS05505_lanthipeptideNZ_JAMDIS010000017.1 Lanthipeptides: M5P45_RS08180_lanthipeptideNZ_JAMYIU010000001.1 Lanthipeptides: NKE44_RS01780_lanthipeptideNZ_JAMYIX010000001.1 Lanthipeptides: NKE54_RS02675_lanthipeptideNZ_JAMYIY010000001.1 Lanthipeptides: NKE64_RS02785_lanthipeptideNZ_JAMYJP010000014.1 Lanthipeptides: NKE68_RS07350_lanthipeptideNZ_LR738722.1 Lanthipeptides: STREPSUIS_RS03955_lanthipeptideNZ_VZMP01000023.1 Lanthipeptides: F6P50_RS09295_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05700_lanthipeptide

Lanthipeptides: SSUD12_RS06540_lanthipeptide

FIKTISASCP

F+KT++ CP

FVKTLTKDCP

14.3%

NZ_FMXP01000004.1:

Lanthipeptides: BLQ04_RS01515_lanthipeptide

FIKTISASCPMV

+IKT++ CP V

WIKTLTKDCPNV

13.5%

NZ_CP022203.1:

Lanthipeptides: allorf_3347911_3348144_lanthipeptide

SRGPSSRVSKIRQ

+RGP RVS R+

ARGPGWRVSAWRR

allorf_17540_17656

Leader:

MRLCRALGA

Core:

LLYLQCSGRGRRAEQKRRCGWAQGSAYHD

Core with dehydrations:

LLYLQCysDhaGRGRRAEQKRRCysGWAQGDhaAYHD

antiSMASH-DB 4.0 matches for allorf_17540_17656

21.9%

NZ_AP023392.1and 4 others:

NZ_CP015557.1 Lanthipeptides: A6M16_RS04830_lanthipeptideNZ_CP065430.1 Lanthipeptides: I5V48_RS05980_lanthipeptideNZ_CP100430.1 Lanthipeptides: NLY76_RS04570_lanthipeptideNZ_JAEUXF010000003.1 Lanthipeptides: JNE40_RS02515_lanthipeptide

Lanthipeptides: H7679_RS04985_lanthipeptide

RAEQKRRCGWAQGSAYH

R + RCGWA +Y

RMTSQGRCGWAFTFSYE

19.4%

NZ_VMLD01000009.1and 3 others:

NZ_VMLI01000004.1 Lanthipeptides: HT696_RS02300_lanthipeptideNZ_VMMD01000015.1 Lanthipeptides: HT711_RS05565_lanthipeptideNZ_VMMI01000027.1 Lanthipeptides: HT721_RS06685_lanthipeptide

Lanthipeptides: HT679_RS04550_lanthipeptide

RAEQKRRCGWAQGSAYH

R + RCGWA +Y

RMTSQGRCGWAFTLSYE

15.9%

NZ_CP014485.1and 3 others:

NZ_CP014485.1 Lanthipeptides: allorf_7106951_7107154_lanthipeptideNZ_CP079112.1 Lanthipeptides: allorf_0069403_0069606_lanthipeptideNZ_CP079112.1 Lanthipeptides: allorf_0069403_0069606_lanthipeptide

Lanthipeptides: allorf_7106951_7107154_lanthipeptide

SGRGRRAEQKRRCGWAQ

+G GR CGWA

AGTGRDGPPSPPCGWAP

with 1 more sequence matches

15.9%

NZ_JAHUVY010000001.1and 1 other:

NZ_JAHUVY010000001.1 Lanthipeptides: allorf_0075041_0075244_lanthipeptide

Lanthipeptides: allorf_0075041_0075244_lanthipeptide

SGRGRRAEQKRRCGWAQ

+G GR CGWA+

AGTGRDGPPSPPCGWAR

allorf_17942_18160

Leader:

MCKPALPKARLKATASWPTNEISTASAELAAISAT

Core:

YCAMLRDPKGTYLSYARSMAFSRSLDFANRCEIRGQT

Core with dehydrations:

YCysAMLRDPKGDhbYLDhaYARDhaMAFDhaRDhaLDFANRCysEIRGQDhb

allorf_19407_19547

Leader:

MARVSFSIRAVSLAS

Core:

LAISCAWIWRDLASASNLLKCSCWAISASRS

Core with dehydrations:

LAIDhaCysAWIWRDLADhaADhaNLLKCysDhaCysWAIDhaADhaRDha

antiSMASH-DB 4.0 matches for allorf_19407_19547

25.8%

NZ_QTND01000003.1:

Lanthipeptides: allorf_157067_157180_lanthipeptide

LAISCAWIWRDLASASNLLKC

LA C RDL++ + L C

LAKRCHRGKRDLSNQTTFLYC

16.7%

NZ_CP073318.1:

Lanthipeptides: JJ691_RS04905_lanthipeptide

AWIWRDLASASNLLKCSCWAISA

AW R A +N+L C+ + A

AWTRRGEAVLNNVLAIGCFVLCA

16.4%

NZ_BMJA01000001.1:

Lanthipeptides: allorf_0188735_0188944_lanthipeptide

AWIWRDLASASNLLK----------CSCWAISAS

A IW D LL+ C CWA++

AGIWNDGQKVRTLLRRANCSLQPARCLCWAVTEP

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

allorf_14049_14240 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 3519.7 Da

Molecular weight: 3522.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3540.3 Da N = 1; 3558.3 Da N = 2

allorf_14388_14576 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 4603.4 Da

Molecular weight: 4606.2 Da

Number of bridges: 3

allorf_14698_14790 - Class II

Cleavage pHMM score: -5.20

RODEO score: 0

Monoisotopic mass: 1852.0 Da

Molecular weight: 1853.3 Da

Number of bridges: 1

allorf_15306_15398 - Class II

Cleavage pHMM score: -5.90

RODEO score: 0

Monoisotopic mass: 2263.2 Da

Molecular weight: 2264.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2282.5 Da N = 1; 2300.6 Da N = 2; 2318.6 Da N = 3

allorf_15423_15605 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 5294.8 Da

Molecular weight: 5298.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 5316.2 Da N = 1; 5334.2 Da N = 2; 5352.2 Da N = 3; 5370.2 Da N = 4; 5388.2 Da N = 5; 5406.3 Da N = 6

allorf_15801_15956 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 3132.6 Da

Molecular weight: 3134.7 Da

Number of bridges: 2

allorf_16408_16578 - Class II

Cleavage pHMM score: -3.50

RODEO score: 0

Monoisotopic mass: 4857.2 Da

Molecular weight: 4860.2 Da

Number of bridges: 3

allorf_17091_17210 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 2861.6 Da

Molecular weight: 2863.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2881.4 Da N = 1; 2899.4 Da N = 2; 2917.4 Da N = 3; 2935.5 Da N = 4; 2953.5 Da N = 5; 2971.5 Da N = 6; 2989.5 Da N = 7

allorf_17540_17656 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 3328.7 Da

Molecular weight: 3330.7 Da

Number of bridges: 2

allorf_17942_18160 - Class II

Cleavage pHMM score: -5.00

RODEO score: 0

Monoisotopic mass: 4169.0 Da

Molecular weight: 4171.7 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4189.8 Da N = 1; 4207.8 Da N = 2; 4225.8 Da N = 3; 4243.8 Da N = 4

allorf_19407_19547 - Class II

Cleavage pHMM score: -5.20

RODEO score: 0

Monoisotopic mass: 3255.7 Da

Molecular weight: 3257.8 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3275.8 Da N = 1; 3293.8 Da N = 2; 3311.8 Da N = 3; 3329.9 Da N = 4