LOCUS       BGC0002699             12569 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Nostoc punctiforme PCC 73102 plasmid pNPUN01, complete sequence.
ACCESSION   BGC0002699
VERSION     BGC0002699
KEYWORDS    .
SOURCE      Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)
  ORGANISM  Nostoc punctiforme PCC 73102
            Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae;
            Nostoc.
COMMENT     URL -- http://www.jgi.doe.gov
            JGI Project ID: 2351359
            Source DNA available from John C. Meeks (jcMeeks@ucdavis.edu)
            Bacteria available from ATCC: ATCC 29133
            Contacts: John C. Meeks (jcMeeks@ucdavis.edu)
            David Bruce (microbes@cuba.jgi-psf.org)
            Quality assurance done by JGI-Stanford
            Annotation done by JGI-ORNL and JGI-PGF
            Finishing done by JGI-LLNL
            Finished microbial genomes have been curated to close all gaps with
            greater than 98% coverage of at least two independent clones. Each
            base pair has a minimum q (quality) value of 30 and the total error
            rate is less than one per 50000.
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. it is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 18:14:36
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 94654
            Orig. end    :: 107223
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..3351
                     /codon_start=1
                     /db_xref="InterPro:IPR007822"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     1032.3; E-value: 0.0)"
                     /gene_kind="biosynthetic"
                     /locus_tag="Npun_AF076"
                     /note="PFAM: Lanthionine synthetase C family protein; KEGG:
                     ana:all2025 similar to MrsD protein"
                     /product="Lanthionine synthetase C family protein"
                     /protein_id="ACC84958.1"
                     /sec_met_domain="DUF4135 (E-value: 5.2e-119, bitscore:
                     386.3, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.4e-65, bitscore:
                     208.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEREMINNEFKTTSTQVKVVQIASKATFLFERLINNNLSLNVTH
                     FNEKEADKRIVDWCKVIAKGDLEVFHKRLEWSNWNIETIRDLFGTEPIFDSQNLPNWVK
                     TLSDIIHILSESNIQKISPNASEPENPYPFEEILLALVAVARQKLLNCLGFDSLSPDTL
                     PLKILSEAAYLNLEKALLQKLFNLSAKALEFEFSISRSFGKNFLSQFIKNTKNVHSTEL
                     YKTFIQKSLADGLLGFFQKYPLLARFIVTTIDFWVEATKEFLERLDADLGEIQQKIHPL
                     ANTENYQAFDTVIEIKSAISDSHNQNRSVIALTFASGRKLVYKPKNLGLEVAFCQFLEW
                     CNQELTLGQNHPSLNLKVLQVINRGDYGWVEYIEQKPCEDEAAAQRFYIRAGMLLCLLY
                     VLGGTDCHNENLIACGENLVLVDMETVMQHEAKLMGVSLDQSATSLATNQLFDSVLRTG
                     LLPMWEFAANDSIACDFSGLGSVEVQPVPIPMPVWKFINTDDMHQGYEKLDRPLEANIA
                     LLNGMPLSPKNYINELVIGFEQMYCFLMRQKEVLLAANSPLNVFHAQKVRFIFRPTRVY
                     GMLLGQVMTPEFLQHGLDWSIQVDVLSRSFLTNGDKPLAWQILLEELKAISQLDIPYFS
                     GLVDGDTLPLGEEKAIVEYFKTSCLSQVRSRLQKLNENDLAQQLSIIQLAFYAKEARIL
                     QTNPSSSISQEAEYDSALVLTSAELLEQAQEIASEIQNRAICGADDSLTWISLTYVLSA
                     ERFQLMPLGYSFYDGNCGIAVFLAALARVTGKTLYRDLALRAIQPLQNYLQTSDTKTDL
                     DTALNLGIGGATGLGSIIYSFVKISQFLEVPQLCADVQRFANLITPTAISADRKFDIIG
                     GAAGAILGLLALAQEQPMVLKQAIACGQHLLKYCNEVFGKTSNLKGLIGFSHGAAGIAY
                     ALLRLYAVTQDTDYLDAARMAIAYENALFYPSVGNWREITPVYDPASLPVFWSTWCHGA
                     PGIALGRLGSLSIDRSEQILTDIEVALKTTQNTALQTIDHLCCGNLGRCEVMLVAAQKL
                     HNPDWYQAAQQLAAIAVARATRKGRYELFGDLPNFVYNPSLFQGAAGIGYQLLRLAYPE
                     ELPSVLLWE"
     subregion       1..12569
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="ribosomal"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..12569
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..3351
                     /locus_tag="Npun_AF076"
     gene            3882..4193
                     /locus_tag="Npun_AF077"
     CDS             3882..4193
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03798"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="Npun_AF077"
                     /product="hypothetical protein"
                     /protein_id="ACC84959.1"
                     /sec_met_domain="TIGR03798 (E-value: 5.4e-14, bitscore:
                     41.0, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQENLEQFYVLVQNSEQLQELLGATENTDSFNELAVRLGQDNGY
                     NFTIQEVDAFVTENLQNVNAELRDEELELVAGGKGKSCPLDTQFTACFLRSGCWGSKC"
     gene            4490..5377
                     /locus_tag="Npun_AF078"
     CDS             4490..5377
                     /codon_start=1
                     /db_xref="InterPro:IPR000182"
                     /locus_tag="Npun_AF078"
                     /note="PFAM: GCN5-related N-acetyltransferase; KEGG:
                     ter:Tery_0901 GCN5-related N-acetyltransferase"
                     /product="GCN5-related N-acetyltransferase"
                     /protein_id="ACC84960.1"
                     /transl_table=11
                     /translation="MYTLNILKDSTAVMYEKMTFPAFQYVLQEINSKESLIAIAASYQE
                     EPVGLVLAEIRTYNQSAEVLSLFVEPSHRCAGIGTNLLNRLETELTYRRCKKVELVYMT
                     GKSTTPALENLLHKCGWTSPQPRMLVCKGEMEKGIQAPWLKQYSQLPAAYTIFPWREIT
                     TQERQAIERQQATQPWIPEDLIPFKYDKQIEPLNSLGLRYQGQVVGWLISHRIFPDTIR
                     YTCAFCRPDIQKKGRMITLFYEAAKLQLNAKIPHFIWTTPMNHQSMVAFVKYRCLPYLT
                     SIQETRIISKLLLG"
     gene            5556..7172
                     /locus_tag="Npun_AF079"
     CDS             5556..7172
                     /codon_start=1
                     /db_xref="InterPro:IPR003997"
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 32.8; E-value:
                     5.8e-10)"
                     /gene_kind="transport"
                     /locus_tag="Npun_AF079"
                     /note="KEGG: ava:Ava_1130 secretion protein HlyD"
                     /product="secretion protein HlyD"
                     /protein_id="ACC84961.1"
                     /transl_table=11
                     /translation="MLLKKQPLLPNKSLERLASPERLDQLMQIVSPKSWLTLISLSSLV
                     ILSIVWSVYGRIPITIEGKGVLIYPRKVIPLESKSSGQLLNLNIKVGDIIQKGQLLATI
                     DQTLLHTQLQQQKSKLTEMTAQNQAASLLQGQGNTQDYKTIQQQRQNAQQRIQELQALS
                     PILRTKSFESIQKQRLQLQQRVTKLEALTPILKRKNHESLQQQRQSFQQRIQAAKAQLP
                     FIEKKVKSFKQLVQQKVVSETELYQTQEEYFKKVEEIAQLETQVKDLEVREGDAQERYI
                     NNQNEIASNLADLQKLELEETNADEAYLKNQNEIAQLRAELKDLDSREANHAKQNLQDS
                     SSRNREIQEVKREIASLEEQLNSNSQIISQHSGRILEITVTPGQVINVGTRLANVGAEN
                     PSNKLLSVTYFPIADGKKIQSGMPIQITPQTVKRERFGGIVGNINDVSPFPITKEAAAS
                     LVGNPELVEGLVSQKQEGFLQVFAELEQDSTTPSGYKWSSSNGPQMKISPGTTTVVRVK
                     VEERAPITFVLPILRSVSGIF"
     gene            7159..9417
                     /locus_tag="Npun_AF080"
     CDS             7159..9417
                     /EC_number="3.6.3.30"
                     /codon_start=1
                     /db_xref="InterPro:IPR001140"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR005074"
                     /db_xref="InterPro:IPR011527"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 303.6; E-value:
                     4.6e-92)"
                     /gene_kind="transport"
                     /locus_tag="Npun_AF080"
                     /note="PFAM: ABC transporter, transmembrane region; ABC
                     transporter related; peptidase C39, bacteriocin processing;
                     SMART: AAA ATPase; KEGG: ava:Ava_1129 ABC transporter,
                     transmembrane region"
                     /product="ABC transporter related"
                     /protein_id="ACC84962.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.9e-38, bitscore:
                     119.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVFFNAYFKLPINPLQHLQKLLPGQGVRVKTPTLLQMEAVECGAA
                     VLGIVLGYYGRIVPLAELRRECGVSRNGSKAAKILQAARRYGLQAKGYKKELHQLQKLC
                     PPYIIFWNFNHFLVVEGFRHQRVYVNDPSTGPRTVSLAEFEEGYTGVVLVMEPSSEFTK
                     SGRKSSILNALWSRLQGCTDALVYCLITGFFLAVVGLAIPVFSQVFVDEILVQERQNWL
                     RPLLLGMFIVAILQGTFTLLRLRYLRRLKIKLAVGMSSRFMWHILRLPVNFYAQRFAGE
                     ISNRTTLNDQVADVLSGKLATTAIDAVMIIFYALVMFQYDWLLTLIAVSLALVNIWTLQ
                     LISRQRVDANQRLIQEYGKVAGVSIAAIQAIDTLKASGLESNFFSRWSGYYTKAVNSQQ
                     ELGVVNQIFSVLPTLLSALSSMLFLVVGGLRVMDGHLSIGMLVAFQSLMHSFHLPVNNL
                     VNFGSTLQELEGNLIRLDDVLSNPIEEVGGKVQGAGDGEGDCSPSVPYILPKLRGYVEL
                     RNITFGYSPLEAPLIENFSLVIKPGQRIAFVGSSGSGKSTIAKLISGLYQPWSGEIFFD
                     NTPKEQISHQIITNSVAMVEQDISLFGGTIRENLTLWDDTIPDRNLLRACRDAAIEDVI
                     LSMSGELDAELIEGGANLSGGQRQRLEIARALANNPSILIMDEATSALDAETEKIIDEN
                     LRRRGCTWIIIAHRLSTIRECDEIIVLEAGKVVQRGTHQKLWQESGVYARLIRMEEEG"
     gene            9675..12569
                     /locus_tag="Npun_AF081"
     CDS             9675..12569
                     /EC_number="3.6.3.27"
                     /codon_start=1
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR011527"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 243.8; E-value: 6e-74)"
                     /gene_kind="transport"
                     /locus_tag="Npun_AF081"
                     /note="PFAM: ABC transporter related; SMART: AAA ATPase;
                     KEGG: ava:Ava_1128 ABC transporter, transmembrane region"
                     /product="ABC transporter related"
                     /protein_id="ACC84963.1"
                     /transl_table=11
                     /translation="MLEQVYIFNSNEPILLNNPSKIWVVEDGSVGLFAVKVNNSVVEGD
                     RCFLCQINQGEALFGTEHTSSNQDCQMLAVPMGETKFIQVNQELFCKLIANADQQAIAW
                     VENWLHKLGTRLYPVAIPMMSVRAGGKPLVVLHNGQTFQAEVGCITWVEIQQGTVRFLG
                     FEELTLTETAAIFPLSSSMWLEAVEEVHLTIAPTAKLLNLDSLLAGLALVHSQLLYGIY
                     LLGEEEAKAELQRLSDRQHLNRRVTQEALTELASTLNSQNQSFVPEGEPLLVTAGAVGK
                     AMGIKIFPPASSENLQQLQEPLEAIALASRIRIRRVIFQDKWWEKDCGPLLAYTQQTNQ
                     PVALLPVSATQYEILDPVQRTRMKVDQHIAATLAPFAYMFYRSLPDRALKIWDLLQFAL
                     KGRQQDILVILFTGIAVTLLGMLTPIATGVIMGNAIPDSDKKLLWQVGLVLLVAALGAA
                     LFQLAQGLTILRMETAVDVSTQAAVWDRLLKEPVAFFRQYTTGDLLSRVSSISTIRRQL
                     SGRTLINLISSSFALFYLGLLFYYNAKLAIVAVIVAIITVAVTTVSGLLLLHQVRPLLE
                     LRGNIFGQTVQLINGISKLRVAGAEERAFGAWSKNYSQQVKLELSTQRVEDAVVVFNSV
                     IPVLTSAVLFWVAASLLGEAQTSTSAGAGLTLGAFLAFNTAFGNFSQGTTELSNTLTET
                     LQVIPQWKRTQPILQTLPEVNLRKTHPGKLIGKIFIDNINFRYDCDASLTLDKVSIQAE
                     PGEFIAITGTSGSGKSTLFRLLLGFETPEAGTIYYDGHDLSRLDVEAVRRQMGVVLQNG
                     QVLSASIFDNITCGARMTLDEAWEAAYLAGLAEDIAKMPMSLHTVVSEGGSNLSGGQRQ
                     RLLIARALALKPRILLLDEATSALDNTTQEIVSQNLEQQKVTRIVIAHRLSTIRNAHRI
                     YVLKAGRIVQQGNFEELAAVEGLFAQLMRRQMMY"
ORIGIN
        1 atggaagaac gtgaaatgat taataatgaa ttcaaaacaa catcaactca agttaaggta
       61 gtgcagattg ccagtaaagc taccttctta tttgaacgat taattaataa taatctgtcg
      121 cttaatgtca ctcatttcaa cgaaaaagaa gctgataaac gtatagtgga ttggtgtaaa
      181 gttattgcta aaggcgacct ggaagtattt cataagcgtt tagaatggag taattggaat
      241 attgaaacaa tacgtgattt atttgggaca gagccaattt ttgatagcca aaacttgcca
      301 aattgggtaa aaactttatc agacattatc cacatccttt cagagtctaa tatccaaaag
      361 atatctccaa acgccagtga accggaaaat ccctatcctt ttgaagaaat attattagct
      421 ctagttgcag tggcacgtca gaaattacta aattgcttag gttttgactc attatctcca
      481 gacactttac cattaaagat acttagtgaa gctgcttact taaatctaga gaaagcttta
      541 ctgcaaaaac tatttaattt aagtgcaaaa gctttagaat ttgaattttc tatttctcgc
      601 agttttggca aaaactttct tagccaattc atcaagaaca cgaaaaatgt gcatagtaca
      661 gagctatata agacttttat tcaaaagtca ttggctgacg gattgttagg attttttcaa
      721 aagtatcctt tgttagctag gttcattgtt acaacaattg atttttgggt agaagctaca
      781 aaggaatttt tagagagact tgatgctgat ttaggagaaa tccagcaaaa aattcatcca
      841 ttagcaaata cagaaaatta tcaagctttt gatacagtta tagaaattaa atcggctata
      901 tctgactccc ataatcaaaa tcgttctgta attgccctca catttgcatc aggcagaaag
      961 ctagtgtata aacccaaaaa tttagggtta gaagttgcct tttgtcagtt tttagaatgg
     1021 tgtaatcaag aattaacatt aggacaaaat catccctctt taaacctcaa agttttacaa
     1081 gttataaacc gaggagatta tggttgggtg gagtatatag agcagaaacc ctgtgaagat
     1141 gaagcagcag cacagcgttt ttatatccga gcaggtatgt tgctatgcct gttatatgta
     1201 ttaggaggaa ctgactgtca caatgagaat ttaatagctt gtggcgaaaa cttagtgttg
     1261 gttgatatgg aaactgtcat gcagcacgaa gcaaaattaa tgggggtttc cttagaccaa
     1321 agtgcaacat cactagccac taatcaactc tttgattcag tccttcgcac tggactacta
     1381 ccaatgtggg aattcgctgc taatgattcc atagcctgcg attttagcgg tcttggtagt
     1441 gttgaggtac agccagtacc aataccgatg ccagtatgga aatttatcaa cactgatgat
     1501 atgcaccaag ggtatgaaaa acttgacaga cctttagagg cgaatatagc gcttttaaac
     1561 gggatgccac tatcaccgaa aaactacata aatgagttag ttattggctt tgaacaaatg
     1621 tattgcttct tgatgagaca aaaagaagta ctgctagctg ctaacagtcc actcaatgta
     1681 tttcatgctc aaaaagtgcg atttatcttt cgtcccacca gagtttatgg aatgcttctt
     1741 ggtcaggtaa tgactccaga attccttcag cacggacttg attggagtat acaagtagat
     1801 gtcttgagtc ggtcatttct gactaatggg gataaaccct tggcttggca gattcttctt
     1861 gaagaactca aggctataag tcagttagat attccctact tcagtggtct ggttgatggg
     1921 gatactttac ctctaggaga agagaaagct atagttgagt attttaaaac atcctgcttg
     1981 tctcaagtta gatcaagatt acaaaagttg aatgaaaatg acttggcaca acaactgagc
     2041 attattcaat tggcttttta tgctaaagaa gcacgaattc tgcaaacaaa tccaagtagt
     2101 tctatatcac aggaggcaga gtatgattct gcgctcgtgt tgacatcagc agaattgtta
     2161 gagcaagcac aggaaattgc cagcgaaatt caaaaccgag ctatctgtgg tgctgatgat
     2221 agcctgactt ggattagttt gacttacgtc ctcagtgctg aacgattcca actgatgccc
     2281 ctgggctata gtttctacga tggtaattgc ggcatcgctg tatttttagc agctttagct
     2341 cgtgtgacag gtaaaacgct atatcgtgat ttagctttga gagctataca gcctctgcaa
     2401 aattatttgc aaacatccga tactaaaaca gacttggata cagcgttaaa tctggggatt
     2461 ggaggtgcta caggacttgg ttccattatc tatagttttg tcaaaatcag ccaattttta
     2521 gaagtgcctc agttgtgtgc agatgtccag cgatttgcta acttaattac acctacagca
     2581 atttctgccg atcgcaagtt tgacattatt gggggagcag caggagcaat tttgggactt
     2641 ttggcacttg ctcaagaaca gccgatggtt ttaaaacaag cgatcgcctg cggtcagcac
     2701 ctgttaaagt actgcaacga agtgtttggg aaaacttcaa atctcaaggg tttaattggt
     2761 ttttctcacg gtgcagccgg tattgcttac gcattgctgc gtctctatgc ggtcactcaa
     2821 gatactgatt acttggatgc ggctcggatg gcgatcgcct acgaaaatgc cttattctat
     2881 ccctcagttg gtaactggcg agaaatcact cctgtttatg accctgcttc actgcccgtt
     2941 ttttggtcaa cttggtgtca tggggctcct ggaattgctc tagggaggtt ggggagttta
     3001 tcaattgatc gttcagagca aattctgact gatattgaag tagccctaaa aactactcaa
     3061 aacactgcct tacaaactat cgaccatctc tgctgtggta acttaggacg atgtgaagtc
     3121 atgctagtag ctgcacaaaa gcttcacaat cctgactggt atcaagctgc tcaacagtta
     3181 gcagccatag cagtagcacg agccacacga aaaggaaggt atgagttgtt tggtgactta
     3241 cctaattttg tatacaatcc ctctttgttc cagggggctg cgggaatcgg atatcaatta
     3301 ctacgactag cttatccaga agaactgccc tcagttctgc tttgggaata aggctgtcac
     3361 aaaagtaaca aatctgagaa agaaaggcag aagttcgagg gcagaaggca aaaggttagg
     3421 agtaacaatt aaaactttag ttctgggtct aaagccagtt tagataaata attataccga
     3481 gactgcttgc agcaaggtat aaaacgtcct tgttacaatc ccactctttt aagggtgggt
     3541 tgccttctgc cttttgaaaa caatttacat actgaagcta ctgataatac aaatttgtcg
     3601 gtagcttact caattttgaa tttttaaact gatagcaatt ttagaaataa accttgtaaa
     3661 gacgcaaaat tttgcggata tattttttaa attttaattt gtataaataa aaaatatcaa
     3721 agtaaatgtg attactcaac aaataatatg tgattgttat agatattttt agcgaataac
     3781 ataataagtg tcagtgcaag agactaaata gaaatactaa atataaaaag tcttttgtac
     3841 tgcaatgcta atcaaaactt catcaatagg aaaaaatagt catgagccaa gaaaacttag
     3901 aacaatttta cgttcttgtt caaaatagtg aacaattgca agaactgcta ggagctactg
     3961 agaacacaga cagttttaat gaattagcag tgagattagg tcaagacaac ggatacaact
     4021 ttacgattca ggaggtagat gcttttgtca ctgagaatct acaaaatgtg aatgctgaac
     4081 tcagagatga agaactagaa ttagtggctg gtgggaaagg taaatcatgc ccactagata
     4141 cacagtttac ggcttgtttc cttagaagcg gttgctgggg tagtaaatgt taataatatt
     4201 tctccactac tgcttaaata tagcaagtaa acaacgctag tttttcaatc tagtatgaca
     4261 gggtgaaaat tccctgtcat acacactcgc atcattgtta tataagtatt taatttttga
     4321 caatatggtt gaacatgaag tttgtaacta tagcaacata tctagaatag ttttattttt
     4381 tattgattga cttcaagaaa acctgtaaaa atattcttct aatatccagt aattaccata
     4441 catatctcaa attataaaat aactaaaaat tagctaagag atcgataaaa tgtatacatt
     4501 gaatatcctc aaagattcaa cagcagtaat gtatgaaaaa atgacatttc cagcttttca
     4561 atatgtattg caagaaataa attccaaaga atctttaatt gcgatcgccg cttcatatca
     4621 agaggaacca gttggtttgg ttctggctga gattcggaca tacaatcaat cagccgaagt
     4681 tttatcctta tttgttgaac cttcacaccg ctgtgcagga ataggtacaa acttattaaa
     4741 ccgcctagaa acagaactaa cctaccggag atgtaaaaaa gtggagttag tttatatgac
     4801 tgggaaatct acaacccctg cattagaaaa tttacttcac aaatgcggtt ggacatctcc
     4861 acaacctcgg atgttagtat gcaaaggaga aatggagaaa ggaatacaag caccttggtt
     4921 aaaacaatat agtcaacttc ctgctgcata taccatattc ccttggcgag aaattacaac
     4981 acaagaacga caagcaattg aacgacaaca ggcgactcag ccgtggattc ctgaagacct
     5041 aattcccttc aaatacgata agcagataga acccttaaac agtctaggtt tacgctatca
     5101 aggacaggta gtaggatggc taattagcca tcgaattttc ccagacacca ttcgctatac
     5161 ctgtgctttt tgcagaccag atatacaaaa aaagggtcgg atgattactc tattttatga
     5221 agccgctaaa ctacaattaa acgctaaaat tcctcacttc atttggacta cccccatgaa
     5281 tcatcaatct atggtggcat ttgttaaata tcgatgctta ccttatttaa cttctatcca
     5341 agaaaccaga atcatctcta aattattgtt gggatagtac ctaccaagat tccttttgca
     5401 tctctactca agattataga caactatagc aatctgattt agccccttct ttaaatcact
     5461 cgtaaagaaa agcaagggaa caggaaacag ggaaaaagta atcaaagtat aatgattttt
     5521 tcaacaataa aacaggagtt ttataactta tatatatgtt actgaaaaag caacccttat
     5581 taccaaataa atcactagaa cgtcttgctt ctcctgaaag actagatcag ttgatgcaaa
     5641 tagttagtcc aaaaagctgg ctgacgttaa tttctttgag ttcattagta atactaagta
     5701 ttgtctggag tgtttatgga cgcataccca tcaccatcga aggtaaagga gtattaattt
     5761 acccccgcaa agtcatacca ctagaatcaa aaagttcagg tcaattatta aatctgaata
     5821 taaaagttgg agatatcatc caaaaaggac agcttttagc aaccattgac caaaccttac
     5881 tccacacaca attgcaacag caaaaatcaa aactcacaga aatgacggca caaaatcaag
     5941 ccgccagctt acttcaaggg cagggaaata ctcaggacta caaaactatc caacagcaac
     6001 gccaaaatgc tcaacaaaga attcaagaat tacaagcttt gtcgccaata ctcagaacca
     6061 aaagctttga atctattcaa aaacaacgtc tacaactgca acagcgagtt acaaaactag
     6121 aagctttaac tcccatcctc aagcgtaaaa atcatgaatc actgcaacag cagcgtcaaa
     6181 gttttcaaca acgcattcag gcagctaaag cgcaactccc ttttatagaa aaaaaagtca
     6241 aaagttttaa acaactagta cagcagaaag tagtttcgga aactgaactt tatcaaactc
     6301 aagaagaata ttttaaaaaa gttgaagaaa ttgctcagtt agaaacccaa gttaaagatt
     6361 tggaagttag agaaggtgat gcccaagaaa gatatatcaa caaccaaaat gaaattgcga
     6421 gcaaccttgc tgacttgcaa aagctagaat tagaagaaac taacgcagat gaggcttacc
     6481 taaaaaatca aaatgaaatt gctcaacttc gggcagaact aaaagatttg gatagccggg
     6541 aagccaatca tgctaaacaa aacttgcaag attcaagcag tcgtaataga gaaattcaag
     6601 aagtaaaaag agagatagct tctttagaag aacaactgaa tagcaatagt cagattatta
     6661 gccaacatag cggacgaatt ttagaaataa ctgtgacacc cggacaggtt ataaatgtag
     6721 gaactcgttt ggcaaatgta ggtgcagaaa acccatctaa caagttgctg agtgtcactt
     6781 attttcccat agcagatggg aaaaaaattc aatctgggat gccgattcaa attacccccc
     6841 aaactgtcaa gcgagaacgt tttggcggta tcgttggcaa tattaacgat gtttcaccat
     6901 ttccaattac taaggaagca gccgctagtt tagtgggcaa ccccgaattg gtggaaggtt
     6961 tagtgtcaca aaaacaagaa ggttttttac aagtatttgc tgaactagag caagattcta
     7021 cgactcccag cggctataag tggtcttctt ctaatgggcc gcaaatgaaa atctcgcccg
     7081 gaactacaac cgttgtacga gtcaaagtcg aagaacgcgc tcccatcacc tttgttttac
     7141 ctatcttgag gtcagtcagt ggtatttttt aatgcttatt ttaagttacc aataaatcct
     7201 ttacagcatt tacaaaaact actgcctggt caaggtgtgc gagtcaaaac tcctactctt
     7261 ttgcaaatgg aggctgtaga atgcggtgcg gctgttttag ggattgtttt aggctattac
     7321 ggacggatag tgccacttgc agaactgcgt cgagagtgtg gagtctcgcg taatggcagt
     7381 aaagctgcaa agatattaca agcagctaga aggtatggac tgcaagcgaa aggctataaa
     7441 aaagaactac accaattaca aaaactttgt cctccataca tcatcttttg gaactttaac
     7501 cacttcttgg tggtggaagg atttcgccat cagcgagttt atgtaaatga ccctagcact
     7561 gggccgcgaa ctgtttccct cgcagaattt gaggagggat atacgggagt ggtgctggta
     7621 atggaaccaa gcagcgaatt caccaaaagt ggtcgtaaat ccagcatatt aaatgcatta
     7681 tggtcaagac tgcaaggctg cactgatgct ttagtttatt gcttgataac tggattcttt
     7741 ttggccgttg tcgggttagc aatacctgtg tttagccagg tatttgtcga tgaaatcttg
     7801 gttcaggaac gacaaaactg gctgcgtcct ttactcttgg gaatgtttat tgtcgccata
     7861 cttcaaggaa cttttacttt actacgattg cgttacctgc gccgtctgaa aattaagtta
     7921 gctgtaggta tgtccagccg ttttatgtgg catattctgc gtttacctgt gaatttttat
     7981 gctcaacgct ttgctggcga aattagcaac cgtacaacac tgaacgacca agttgctgat
     8041 gttctttcag gaaaactagc aactactgct attgatgcag ttatgatcat tttttacgct
     8101 ttggtcatgt tccaatatga ctggttgttg actcttattg ctgttagttt agccttagta
     8161 aatatttgga cattgcagtt gatttctaga cagcgtgtag atgccaacca gcgattaatc
     8221 caagagtatg gcaaagtagc aggtgtatct attgctgcta ttcaagcaat agatacactg
     8281 aaagcatctg ggttagaatc aaatttcttt tctcggtggt ctggctatta caccaaggcg
     8341 gtaaattctc agcaagaact aggggtagta aatcaaatat tttctgtcct acctacctta
     8401 ctttctgctt tgtcttcgat gttgttttta gttgtaggcg gtttgcgggt gatggatgga
     8461 catttgagca ttgggatgct ggtagctttt caaagcttaa tgcatagctt ccatctacct
     8521 gtcaacaatc tagtcaactt tggtagcact cttcaagaat tagaagggaa tttaatccgc
     8581 cttgatgatg tactaagtaa cccgatagaa gaggtagggg ggaaggtgca gggggcaggg
     8641 gacggagagg gagattgctc cccctctgtc ccctatattc ttcccaaatt acgaggatat
     8701 gtcgagttgc gaaacattac atttggctac agtcctttag aagcaccttt gattgaaaac
     8761 tttagcttgg taattaaacc cggacagcga attgcattcg tcggtagtag cggttctggc
     8821 aagtctacga tcgccaaact cattagtgga ctttatcaac cttggtcagg agaaattttc
     8881 tttgataata cacccaaaga acagatttct caccagataa tcactaattc agtggcaatg
     8941 gtcgagcaag atatctcatt atttggggga accatcagag aaaatttaac actttgggat
     9001 gacaccatac cagacagaaa tttgttgcgg gcttgccgag acgcagctat tgaggacgta
     9061 attctctcaa tgtctggaga attggatgca gagttaatcg aaggtggtgc taatctcagt
     9121 ggaggtcaac ggcaaagact ggaaatcgcc cgtgctttag cgaacaatcc ctctatccta
     9181 attatggatg aggccaccag tgccttagat gcagagacgg aaaaaattat cgatgaaaat
     9241 ttgcggcgac ggggatgtac ttggattatc attgcccatc gactgagtac tatccgagag
     9301 tgcgatgaaa tcatcgtcct cgaagctgga aaggtagtac aaaggggtac tcatcaaaag
     9361 ttgtggcaag aatcgggagt gtatgcgaga ttaattcgca tggaagagga gggatgaggg
     9421 agcaggggga gcaagagaac aaataaataa ctcttacctt ctagtagtct gccaacccaa
     9481 aaatgttagg tggaggtagg cagaggtgca ggggtgcaga ggagagttca atgtgccttg
     9541 ttctttcccc tctgcccttg gggctaacca cctttgcatt gtttccttgg cgtactacta
     9601 actcctcact gctcactttt cactcagcac tctcagatac gtaaaaaagt tatttgcgat
     9661 tggtataagt gtaaatgcta gaacaagtgt atatttttaa tagcaatgaa cctattcttt
     9721 taaacaatcc ttctaaaatt tgggtagttg aagatggctc ggtaggctta tttgcagtca
     9781 aagttaacaa tagcgttgtg gaaggcgatc gctgtttttt atgtcagatt aatcaaggtg
     9841 aagcattgtt tggcactgaa catacatcta gcaatcagga ctgtcagatg ttggcagtgc
     9901 caatgggaga gacaaaattc atacaagtca atcaggaatt attctgtaag ttaatcgcca
     9961 atgcggatca acaggcgatc gcttgggtag aaaattggtt acataagctt ggtactagac
    10021 tttatccggt ggctataccg atgatgtcgg tgagggctgg gggtaaacct ctggttgttc
    10081 tccacaatgg tcagactttc caagcagaag taggttgtat cacttgggtg gagattcaac
    10141 agggaactgt caggtttttg ggatttgagg aattaacctt gactgagaca gcagcaattt
    10201 ttccgctcag ttcttcgatg tggttagaag cggtagaaga agtacatctg actattgcgc
    10261 caactgccaa acttctcaac ctagattctc tacttgcggg actggctttg gttcatagcc
    10321 aattgctgta cggtatttat cttttgggtg aagaggaagc aaaagcagaa ttacaacggt
    10381 taagcgatcg ccaacatctc aatcgtcgag ttacacaaga agcattaacc gaactcgcat
    10441 caaccctgaa ttctcaaaac caaagttttg taccagaagg tgagccgttg ttagtaactg
    10501 ctggtgcggt aggcaaggcg atggggataa aaattttccc tccagcctcc tcagaaaacc
    10561 tccagcaact tcaggaacca ctagaggcta ttgctttagc ctctcgcatt cggatacggc
    10621 gggtaatttt ccaggacaaa tggtgggaga aggattgtgg cccgttactt gcttacaccc
    10681 agcaaaccaa ccaaccagta gcactactgc cagtttcggc tactcagtat gaaatcttag
    10741 atcctgtgca gcgaacccgt atgaaggttg atcaacatat agctgcgaca ctggctccct
    10801 ttgcctatat gttttatcgg tctttgccag atcgtgcgct gaagatttgg gatttgcttc
    10861 aattcgcatt aaaaggtcgg cagcaggata ttctagttat tttatttact ggtattgcag
    10921 tcacattact gggaatgctg acaccaattg ccactggggt gattatgggc aatgcaattc
    10981 ccgatagcga caagaaatta ttgtggcaag taggattggt tctgttggtt gcagctttag
    11041 gagcagccct atttcaatta gctcaggggt tgacaattct gcggatggaa acggctgttg
    11101 atgtttccac tcaagccgca gtgtgggatc ggctgttaaa agagcctgtg gcttttttcc
    11161 gacagtacac cactggtgac ttgctgtccc gtgtatcttc tattagtaca atccgccgcc
    11221 aacttagtgg tagaaccctg attaatctca ttagtagttc cttcgccttg ttttacttgg
    11281 ggttgttgtt ctactacaat gctaagttag ccatagtagc tgtgatagtc gcaataatta
    11341 ctgttgcggt gactacagtt tctggtttac ttttgttgca tcaagtccgt cccctgctag
    11401 aactgcgggg aaatattttt ggacagacag tacagctaat caatggcatt tctaaattac
    11461 gtgtagctgg tgctgaagaa cgcgcctttg gagcttggag taaaaactat agtcagcaag
    11521 tgaaactaga acttagtacc cagcgtgtgg aagatgctgt tgtagttttc aattctgtca
    11581 tacccgtact gacatcggca gtactatttt gggttgctgc tagcttgctg ggggaagctc
    11641 aaacttcaac ctcagcaggt gcaggactaa cgttgggggc ttttctggct tttaacactg
    11701 cctttggcaa ttttagccaa ggaaccacag aattgagcaa cactctaaca gaaaccttgc
    11761 aagttattcc gcaatggaaa cgcacccaac caattctgca aactttaccg gaagtaaatt
    11821 tgcgaaaaac ccatccaggg aaactgatag gcaaaatttt tatagataat atcaactttc
    11881 gctatgactg tgatgcttca ctgaccttgg ataaggttag cattcaagcc gaaccaggag
    11941 aatttattgc gatcactggg acttctggca gtggtaagtc aactttattc aggttattgc
    12001 ttggctttga aactcctgaa gctggtacta tctactatga tggtcacgat ctgtctcggc
    12061 tggatgtaga agcagtacgc cgacagatgg gtgttgtttt acaaaatggt caagttttgt
    12121 cagcttcgat ttttgataac atcacctgcg gcgcgaggat gacattagat gaagcttggg
    12181 aagcagctta tctggctgga ttggctgaag atatcgccaa gatgcctatg tctttgcata
    12241 ctgtggttag tgaaggtggt agcaatctct ctggtggaca aaggcaaagg ctgctaattg
    12301 ctcgtgcttt agcattgaag ccgcggattt tgctgttaga tgaagccacc agtgctttgg
    12361 ataacacaac ccaagaaatt gtcagtcaaa acttagaaca acaaaaggtg actcgaatcg
    12421 tcattgccca ccgcctgagt acaattcgca atgctcatcg tatttatgta ctgaaggctg
    12481 gccgaattgt acaacagggt aactttgaag aattggctgc tgttgaggga ttgtttgccc
    12541 agttaatgcg aagacagatg atgtattaa
//
