BGC0002699 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002699 (Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	23,351	High	nostolysamide A/nostolysamide B	ribosomal:RiPP

BGC0002699 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 23,351 nt. (total: 23,351 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 23,352
Label		BGC0002699

Tailoring functions

Lyases: cyclase

Npun_AF076: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002699.2	1.00	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0000554.4	0.51	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000588.5	0.50	ribosomal	microcin L	Escherichia coli
BGC0002703.2	0.50	ribosomal	archalan α	Halorussus salinus
BGC0002698.2	0.49	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001210.5	0.48	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0002704.2	0.47	ribosomal	archalan β	Halorussus salinus
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000589.5	0.45	ribosomal	microcin M	Escherichia coli Nissle 1917

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002699.2	1.00	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0000554.4	0.51	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000588.5	0.50	ribosomal	microcin L	Escherichia coli
BGC0002703.2	0.50	ribosomal	archalan α	Halorussus salinus
BGC0002698.2	0.49	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001210.5	0.48	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0002704.2	0.47	ribosomal	archalan β	Halorussus salinus
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000589.5	0.45	ribosomal	microcin M	Escherichia coli Nissle 1917

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for Npun_AF076

allorf_00664_00870

Leader:

MLHLYHQLEKDLNQYLTLSQPELHELILA

Core:

TAFLDAENLSLCCLPVLLLLLSHDEGISTLRLLRFVLDC

Core with dehydrations:

DhbAFLDAENLDhaLCysCysLPVLLLLLDhaHDEGIDhaDhbLRLLRFVLDCys

antiSMASH-DB 4.0 matches for allorf_00664_00870

25.0%

NZ_KV793075.1:

Lanthipeptides: allorf_044618_044788_lanthipeptide

DAENLSLCCLPVLLLLLSHDEGISTLRLLRFV

+A CC P L+ H LRL F

EAPKKFGCCRPGSTLVRQHPRSSVALRLRLFT

20.4%

NZ_JABBWU010000018.1:

Lanthipeptides: allorf_001126_001335_lanthipeptide

FLDAENLSLCCLPVLLL

FLD LCCLP LL

FLD----QLCCLPTPLL

allorf_03926_04042

Leader:

MLNLDQPDFAASIHLVVNAM

Core:

LQLSLSCDNLALVINTIY

Core with dehydrations:

LQLDhaLDhaCysDNLALVINDhbIY

allorf_07000_07104

Leader:

MFNCDRHFHYYFFTVTNQLQSSDSSRTSTGA

Core:

NSC

Core with dehydrations:

NDhaCys

allorf_19461_19616

Leader:

MSSEELVVRQGN

Core:

NAKVVSPKGRGERTRHIELSSAPLHLCLPPPNIFGLADY

Core with dehydrations:

NAKVVDhaPKGRGERDhbRHIELDhaDhaAPLHLCysLPPPNIFGLADY

antiSMASH-DB 4.0 matches for allorf_19461_19616

100.0%

NC_010631.1:

Lanthipeptides: allorf_104115_104270_lanthipeptide

NAKVVSPKGRGERTRHIELSSAPLHLCLPPPNIFGLADY

20.5%

NZ_RCOL01000001.1:

Lanthipeptides: allorf_2499994_2500137_lanthipeptide

PKGRGERTRHIELSSAP

P+ RG RTR S+P

PRARGPRTRPWRAWSSP

14.0%

NZ_JALGBX010000020.1and 1 other:

NZ_JANAVF010000016.1 Lanthipeptides: NLX94_RS30150_lanthipeptide

Lanthipeptides: MTF69_RS28785_lanthipeptide

PPPNIFGLAD

PPP+I G+A

PPPSISGIAT

allorf_22664_22837

Leader:

MRQQGCRGAGEKEEVLGI

Core:

CVRIFRNFALLPCPSAILTLHTLQLNLVPFDLEVHIAEN

Core with dehydrations:

CysVRIFRNFALLPCysPDhaAILDhbLHDhbLQLNLVPFDLEVHIAEN

antiSMASH-DB 4.0 matches for allorf_22664_22837

100.0%

NC_010631.1:

Lanthipeptides: allorf_107318_107491_lanthipeptide

CVRIFRNFALLPCPSAILTLHTLQLNLVPFDLEVHIAEN

allorf_23101_23226

Leader:

MWRCAIEITASIFM

Core:

YLQVLRRVCKNSGLLNLVSFAKARKVT

Core with dehydrations:

YLQVLRRVCysKNDhaGLLNLVDhaFAKARKVDhb

antiSMASH-DB 4.0 matches for allorf_23101_23226

100.0%

NC_010631.1:

Lanthipeptides: allorf_107755_107880_lanthipeptide

YLQVLRRVCKNSGLLNLVSFAKARKVT

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

allorf_00664_00870 - Class II

Cleavage pHMM score: -2.40

RODEO score: 0

Monoisotopic mass: 4238.3 Da

Molecular weight: 4241.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 4259.0 Da N = 1; 4277.1 Da N = 2

allorf_03926_04042 - Class II

Cleavage pHMM score: -6.20

RODEO score: 0

Monoisotopic mass: 1938.1 Da

Molecular weight: 1939.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1957.3 Da N = 1; 1975.3 Da N = 2

allorf_07000_07104 - Class II

Cleavage pHMM score: -5.50

RODEO score: 0

Monoisotopic mass: 304.1 Da

Molecular weight: 304.3 Da

Number of bridges: 1

allorf_19461_19616 - Class II

Cleavage pHMM score: -7.20

RODEO score: 0

Monoisotopic mass: 4180.3 Da

Molecular weight: 4182.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4200.8 Da N = 1; 4218.8 Da N = 2; 4236.9 Da N = 3

allorf_22664_22837 - Class II

Cleavage pHMM score: -3.90

RODEO score: 0

Monoisotopic mass: 4375.4 Da

Molecular weight: 4378.2 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4396.2 Da N = 1

allorf_23101_23226 - Class II

Cleavage pHMM score: -5.50

RODEO score: 0

Monoisotopic mass: 3021.8 Da

Molecular weight: 3023.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3041.7 Da N = 1; 3059.7 Da N = 2