BGC0002702: GP6738 biosynthetic gene cluster from Streptomyces sp. WAC 06738
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Location: 7,773,512 - 7,852,876 nt. (total: 79,365 nt).
This entry is originally from NCBI GenBank CP029618.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002702
Short description GP6738 biosynthetic gene cluster from Streptomyces sp. WAC 06738
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP029618.1
7785350 - 7842803
via Heterologous expression
Compounds
  • GP6738
Species Streptomyces sp. WAC 06738 [taxonomy]
References
Chemical products information
GP6738 Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • DMB38_33810
  • AZM50104.1
 7785350 - 7786012 (+) enoyl-CoA hydratase
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    • DMB38_33815
    • AZM50105.1
    		 7786009 - 7787313 (+) enoyl-CoA hydratase
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      • DMB38_33820
      • AZM50106.1
      		 7787423 - 7788226 (+) alpha/beta hydrolase
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        • DMB38_33825
        		 7788472 - 7789124 (+) DNA-binding response regulator
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          • DMB38_33830
          • AZM50107.1
          		 7789134 - 7790435 (+) two-component sensor histidine kinase
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            • DMB38_33835
            • AZM50108.1
            		 7790585 - 7790815 (+) MbtH family protein
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              • DMB38_33840
              • AZM50109.1
              		 7790859 - 7792991 (+) ABC transporter
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                • DMB38_33845
                • AZM51139.1
                		 7793512 - 7803210 (+) non-ribosomal peptide synthetase
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                  • DMB38_33850
                  • AZM50110.1
                  		 7803207 - 7807841 (+) non-ribosomal peptide synthetase
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                    • DMB38_33855
                    • AZM51140.1
                    		 7807877 - 7812421 (+) non-ribosomal peptide synthetase
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                      • DMB38_33860
                      • AZM50111.1
                      		 7812509 - 7826317 (+) non-ribosomal peptide synthetase
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                        • DMB38_33865
                        • AZM51141.1
                        		 7826355 - 7832876 (+) non-ribosomal peptide synthetase
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                          • DMB38_33870
                          • AZM50112.1
                          		 7833007 - 7834170 (+) cytochrome P450
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                            • DMB38_33875
                            • AZM50113.1
                            		 7834179 - 7835393 (+) cytochrome P450
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                              • DMB38_33880
                              		 7835418 - 7835612 (+) ferredoxin
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                                • DMB38_33885
                                • AZM50114.1
                                		 7835854 - 7836396 (+) hypothetical protein
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                                  • DMB38_33890
                                  • AZM50115.1
                                  		 7836393 - 7837775 (+) hypothetical protein
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                                    • DMB38_33895
                                    • AZM50116.1
                                    		 7837772 - 7838500 (+) ABC transporter ATP-binding protein
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                                      • DMB38_33900
                                      • AZM50117.1
                                      		 7838497 - 7839753 (+) ABC transporter permease
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                                        • DMB38_33905
                                        • AZM50118.1
                                        		 7839931 - 7840584 (+) DNA-binding response regulator
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                                          • DMB38_33910
                                          • AZM50119.1
                                          		 7840565 - 7841734 (+) two-component sensor histidine kinase
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                                            • DMB38_33915
                                            • AZM50120.1
                                            		 7841769 - 7842803 (-) hypothetical protein
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                                              Biosynthesis information

                                              Biosynthetic modules

                                              Name
                                              Unk01
                                              Type
                                              nrps-type1
                                              Genes
                                              DMB38_33850
                                              Substrates
                                              tryptophan (evidence: Sequence-based prediction, Mass spectrometry)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk02
                                              Type
                                              nrps-type1
                                              Genes
                                              DMB38_33860
                                              Substrates
                                              4-hydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk03
                                              Type
                                              nrps-type1
                                              Genes
                                              DMB38_33860
                                              Substrates
                                              3,5-dihydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk04
                                              Type
                                              nrps-type1
                                              Genes
                                              DMB38_33860
                                              Substrates
                                              tyrosine (evidence: Sequence-based prediction, Mass spectrometry)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk05
                                              Type
                                              nrps-type1
                                              Genes
                                              DMB38_33845
                                              Substrates
                                              3,5-dihydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk06
                                              Type
                                              nrps-type1
                                              Genes
                                              DMB38_33845
                                              Substrates
                                              3,5-dihydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk07
                                              Type
                                              nrps-type1
                                              Genes
                                              DMB38_33845
                                              Substrates
                                              valine (evidence: Sequence-based prediction, Mass spectrometry)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk08
                                              Type
                                              nrps-type1
                                              Genes
                                              DMB38_33855
                                              Substrates
                                              3,5-dihydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk09
                                              Type
                                              nrps-type1
                                              Genes
                                              DMB38_33865
                                              Substrates
                                              3,5-dihydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Annotation changelog

                                              Entry version: 2

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-10-07
                                              Update chemical activity to schema version 2.11
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 1

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-09-15
                                              Entry added
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              2022-09-15
                                              Updated bioactivity data
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              2022-09-15
                                              Added NRP substrate specificities
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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