LOCUS       BGC0002703             13028 bp    DNA     linear   CON 22-FEB-2023
DEFINITION  Halorussus salinus strain YJ-37-H Scaffold1, whole genome shotgun
            sequence.
ACCESSION   BGC0002703
VERSION     BGC0002703
KEYWORDS    .
SOURCE      Halorussus salinus
  ORGANISM  Halorussus salinus
            Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria;
            Halobacteriales; Halobacteriaceae; Halorussus.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            ML974127.1.
            Bacteria and source DNA available from School of Food & Biological
            Engineering, Jiangsu University.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 18:15:07
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 1550021
            Orig. end    :: 1563049
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..951
                     /EC_number="3.4.24.-"
                     /GO_component="GO:0031012 - extracellular matrix [Evidence
                     IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]; GO:0008270 - zinc ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EPL00_RS07775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="matrixin family metalloprotease"
                     /protein_id="WP_135851043.1"
                     /transl_table=11
                     /translation="MTATVTATTTEETEADNPWGRRHVTVAVRNEAAPSRNVAVLVEEA
                     LAYWNGEGREYADYDVTFVPSSNADKADVVVEFVGRIESCDGSDTDSTVGCAPLLGART
                     TPSDPTRVQVVAGYSNESTVEILKHEFGHVVGVEHGEEPTATMRAMSAVTYLSQPDLRD
                     RAVPWRNSTLAVNVDVSALPDHDREEAREQIRHALDYYESGADGAVPSNVSFVAASNRS
                     AADLRIRVPEEAFDCGGERLREGSCGESWVYDTDTDDAPEYFAEYEIRVRGIDTDAIGW
                     HVGYWLSDAMGLYGDELPEPFVDGGDGHRRNDWWE"
     subregion       1..13028
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="ribosomal"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..13028
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..951
                     /locus_tag="EPL00_RS07775"
     gene            1279..2406
                     /locus_tag="EPL00_RS07780"
     CDS             1279..2406
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1282:extracellular
                     ligand-binding receptor (Score: 104; E-value: 1.3e-31)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007979048.1"
                     /locus_tag="EPL00_RS07780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_135851042.1"
                     /transl_table=11
                     /translation="MGTILPLSASGLKQIAQDHLEAVKQAVRDVNRAGGPLGREVKLSV
                     EETDGTPKQTNAALESLAGDGVVGIVGPLTSGNSLSITDRLAEERIVAVSQSATNPKLE
                     TAGVADERKFFGRTIANDAQQATVMAKVLEEERYIGADEAALLYVDNAFGTGLADEIER
                     KVSGTETVRVPFEAGNDSYADEVGTVIDAGVDAVAFVNVPGENAVVETLGTSDFEGQTV
                     LSTGYVTGDLPDYMDGMYSASVAEADAAGEVELRQKLREFAPLTAFTLQCYDALFLQAL
                     AIERAGEASGPAISENIRAVSGGRGHTVSVNDFGRAVDLFDAGREVNYQGASSSVDLNE
                     NLEPLNPYIVQRVENGEPTKLELLQESYFSGGDAA"
     gene            2403..4832
                     /locus_tag="EPL00_RS07785"
     CDS             2403..4832
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1061:methyl-accepting
                     chemotaxis protein (Score: 217; E-value: 8.3e-66)"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007979049.1"
                     /locus_tag="EPL00_RS07785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyl-accepting chemotaxis protein"
                     /protein_id="WP_135851041.1"
                     /transl_table=11
                     /translation="MNGPDRERLDELTTRIESRLPRRIRRSYAAKFGAVLVGVVLLMLV
                     VGLYVQIQAGDIVREDTRAQISGAATDEAEALQKWVTKQRSTTRFLAEAVSRDMTTAER
                     RALLEQKLIDLPSEVQAIHYVDTETGEILASTDDDAIGTTPAGSQASWAGGSLSFEGPS
                     EVVVTDPYEVGDDPVVAFATPTDRSGRMLVVTASLAKRSHALSSPMATGDIKVVNEDET
                     IVFDNRNSRLLGTYERDSSVVEKGLVGQSGVSDMPLLPLFDRGGEVRAYTPVVGTDWVL
                     LYHVPTSDAMAVQTKVTENVVLIVIAAVLGLALVGLTIGRGTAKSLEQVADTADDIASG
                     KLDVELPETTREDEMGRLFGSFGSMREYLNTVADQADALAKQEFDDPVLDEPVPGTFGE
                     SLERMRHDLEEMVTNIDAAREEAQSAKAEAEETNAALERKAAEFGRVMERAADGDLTQR
                     MDTESPTEAMTQIAEEFNAMLAELEATVADVSQFAETVAASSQEVTASTAEIEDASQQV
                     SESTQVMSSAAEDQSARLDRTAGEMNDLSATIEEVAASAEQVAKAATHTESLGQQGREA
                     AQEAIDEMRRIEDGTESTVQQMEELEAEIAHIGEVVDLIRSIADQTNMLALNANIEAAN
                     TDESSDGFEVVANEVKALADETKEAVGDIDDRIEAIESGATETVEDIRETRDAVSEGVR
                     TVREAQEALEKVVDNVEETTDGIREISDATDDQSMTTQEVVGMVDEITDISDDTADEAT
                     DIAAATEEQTASLKEVSRSAEELSERAEALAATVDQFEVGHEDERVSQRTDSPPSR"
     gene            4983..8309
                     /locus_tag="EPL00_RS07790"
     CDS             4983..8309
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     666.9; E-value: 8.8e-202)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007983023.1"
                     /locus_tag="EPL00_RS07790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_135851040.1"
                     /sec_met_domain="DUF4135 (E-value: 9.8e-76, bitscore:
                     244.7, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.7e-47, bitscore:
                     150.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSVFTDEDRREIAGRARTLAERLDGPANVAEESPPIDPERVLDE
                     WRATFPDEESFRARLAHEDLTEETVREHIAATRWPADEPLPDWIDRLSRLVGRVESSTE
                     ADRDAAATPDETPFEELLAAVVSVAREGVAVDSVPVETISSLERQLAERLESLCVRPLY
                     VEFKSFVEHHDPELAATSPDEVADPPTDYYERFVAAMFDGGFRSLCLEYPVLARQLVSL
                     VGDWREAVEELCRRVAADSDALRDEFDVRGDVTDLDALAADAHAGGRVPVRVAFEEGAV
                     VYKPRPVGGEVAFYEILGRLDDHLSTPDFDSPTLLEREGYGWMELREYRDLSDQSAADE
                     YYERAGAVLGLAYLLNFTDCHYENVVAEGDAPTILDGETVFHPHVESEAKPFETEASAV
                     VDRSVLLSVLLPFSVGDPRADRGGRFADKVAGLGSDGDETPLPGKSEPTIEAVGTDVMS
                     VEMEPVTVDPSENTPSIDGTDLPPEESVDALVAGFEETYETVRDLHDEGRFLADIATPE
                     LVAGVETRLLYRSTGRYAELLRSTAARNPLRDGARLTVEFEELAVPFFDGTVESDRLWE
                     LYDAERRSLRKLDVPRFASRADESSLFHRGERLDATVDRTGYEFVRQRLDAMDDFDQRR
                     QSWLIREAVGEVTTAEGPPPSGDEATGRDGNGDRNGNGSRRDDRFRREAIDLFEEAADA
                     RVEATDEPSWVSIVPESGINLYPADDSLFWGRGGVALTAAALADETGRDRYRRLADETL
                     APVVERIFEGSVEFDHGGMQGIGSVVYVLSVVAELLGDDRYREAALAAAETVTSERVAE
                     ADTFDVVDGVAGTLLGLLAYYERYGDEDRSGDGGDEEGGDDGDASPDILRRAADCGDRL
                     LDARTEVDGYRVWETTSDDVPYTGFAHGSSGIAYALARLAAATDEDADRNGNADRNGNT
                     DRDGNTDRDGNADRYADAVREALAFESSLYDPSRTNWRQAATRETYQDRWCHGRTGMAL
                     ARIGIGELLGDDALVADAREALAATAADDGASLDNLCCGNFGRVEALLVGARRAGCDDA
                     LAGDLAGRCLARRERDGLLSLPAHDSAFVNPTFFDGVSGPSYTLLRLRNPETLPSVLLL
                     E"
     gene            8499..8645
                     /locus_tag="EPL00_RS07795"
     CDS             8499..8645
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EPL00_RS07795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_162224177.1"
                     /transl_table=11
                     /translation="MSVAIEADAGSKEQYDSEFTVETTEDVPEQEAGHRDGCGFTCSPF
                     SSW"
     gene            8965..9621
                     /locus_tag="EPL00_RS07800"
     CDS             8965..9621
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EPL00_RS07800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_135851039.1"
                     /transl_table=11
                     /translation="MTTHHLASWLLKHSDVPVTVLKPVATRLGVSTNYLGAALFAGQLV
                     YENQETIVKYADRGGVRVGGFLHRRAVERYGEDHALTQHLGENVAALDEAFEGTEEEAV
                     TFAEFYRRLRAVDRDAPRLTPPAELLDADLPDADLPDARLPDDAMPDVDFSDERLPDVD
                     LPDGRLPDVDVSGVLGGATAAVADQRDRLRDLRPDFGDDADDESDPVEIPVRDEN"
     gene            9773..9916
                     /locus_tag="EPL00_RS07805"
     CDS             9773..9916
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EPL00_RS07805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_162224178.1"
                     /transl_table=11
                     /translation="MTSSRADRAGRPATGDSSGRLRTADCTDRPRTADRTDRLPTADAP
                     HR"
     gene            9913..10323
                     /locus_tag="EPL00_RS07810"
     CDS             9913..10323
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007983456.1"
                     /locus_tag="EPL00_RS07810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_135851038.1"
                     /transl_table=11
                     /translation="MKSPEHAALGSVASLLLVAALPISIPVEAALLVAYGVLLSVFVDL
                     DHFVVARYLAGDWSHFRRCVADPKFAFTEQESVFDGVDTQTLETLRLLSHLLLGGAWVG
                     LLGLVRPVYALFTAGVLYVHVVADLLRDADVA"
     gene            10384..11895
                     /locus_tag="EPL00_RS07815"
     CDS             10384..11895
                     /EC_number="2.7.7.7"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004962529.1"
                     /locus_tag="EPL00_RS07815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA polymerase IV"
                     /protein_id="WP_135851037.1"
                     /transl_table=11
                     /translation="MTGGSRLPGTPDDDETGDPIVLHVDMDCFYAACERRREPRLEGEP
                     VVVGMGYEGGETHGAVATASYEAREYGVDSAQAISTALERLPRKAAVAAENGEDSDRPA
                     SDVDPEEAGYYRPVDMDYYEEVSSEVKEILHESADVVREVSIDEAYLDVTDRTAWEVAE
                     GFARHVKHRIDREVGVTASVGVAPNMSAAKIASDHDKPDGLVVVEPGEVGDFLAPLDVG
                     EIHGVGPVTARKLRGMGIETAADLAVADRAELEARFGERGAEMHRRARGEDRREVTPTG
                     RPKSLSRESAFTEATDDDERKRDQIRTLAEAVADRARRKGAMYRTIGIKAVTPPYDVNT
                     RAKSLPGPVDEPELVEEVALELLGEFSGVEVRKVGVRVSNLSFADGEQASLGDAWGSSG
                     DDAERAASEAPNPEDDGQASLGRQWDDDSASGDNDDDSGGDSASEPPASDLDGQLSLAR
                     EWDVADDASGELAVNDAEETDSDGTDPDQRDESDPEGQVSLDDFG"
ORIGIN
        1 gtgacggcta cagtgaccgc gacgacaacc gaggagaccg aggccgacaa cccgtggggc
       61 agacggcacg tgacggtcgc ggtccggaac gaggccgccc cgtcgcggaa cgtcgcggtg
      121 ctggttgagg aggcgctggc gtactggaac ggtgagggcc gcgagtacgc cgactacgac
      181 gtgaccttcg tgccctcctc gaacgcggac aaagccgacg tggtcgtcga gttcgtcggg
      241 cgaatcgagt cctgcgacgg gagtgacacc gactccacgg tcggatgtgc gccactcctc
      301 ggcgcgcgga cgacgccgag cgacccgacg cgagtgcaag tcgtcgcagg gtactcgaac
      361 gaatcgacgg tcgagattct gaaacacgag ttcgggcacg tcgtcggcgt cgaacacggc
      421 gaggagccga ccgccacgat gcgggcgatg tccgcggtca cgtacctctc gcaaccggac
      481 ctgcgcgacc gggcggtgcc gtggcgaaac agcacgctcg cggtcaacgt agacgtgtcg
      541 gcgctaccgg accacgaccg cgaggaggcc cgcgagcaga ttcgccacgc gctcgactac
      601 tacgagtcgg gggccgatgg cgcggttccg agcaacgtct cgttcgtggc ggcgtctaac
      661 cggtcggccg ccgacctgcg gattcgcgtc cccgaggagg cgttcgactg cggcggcgag
      721 cgtctacggg aaggttcctg cggagagtcg tgggtgtacg acaccgacac ggacgacgcg
      781 ccggagtact tcgccgagta cgagattcgc gtccgaggta tcgacaccga cgctatcggc
      841 tggcacgtcg gctactggct ctcggacgcg atgggcctct acggagacga acttcccgaa
      901 cccttcgtcg atgggggaga cggccaccgt cgaaacgact ggtgggagtg accgacgccg
      961 cgattcggag acgaccaacc gtcaacagtt tcgtgcgcgt atctgctact tctcccctcg
     1021 atatcggatg cccgagagat tttcagtaaa taaagaaaaa ctttattcta atttaatgcg
     1081 taagggcgat ttctaacaac aaaacgtcgg gttcggcgga acaaccggaa taattatatt
     1141 tggaatgtag aaacgttccg acgaatggca tcaaacctat ctagaagaga atacctgaaa
     1201 ttatctgtcg gctcgatagg tgtttcgacc gggacgaccg gctgtctcgg cggctcgatc
     1261 ggcgactcac cggttcgggt gggaactatc ctaccgctct cggcgtcggg gctgaaacaa
     1321 atcgcccaag accacctcga agccgtcaaa caagcggtca gggacgttaa cagagcgggc
     1381 ggacctctcg gtcgagaggt gaaactctcc gtcgaggaga ccgacggcac tccgaaacag
     1441 acgaacgccg ccttggaatc gctcgccgga gacggcgtgg tcggcatcgt cggcccgctc
     1501 acatcgggta attctctctc gattaccgac cgactcgccg aggagcgaat cgtggcggtg
     1561 agtcagtccg cgacgaatcc gaagttagag acggcgggcg tcgccgacga gcgcaagttc
     1621 ttcggccgga cgatagccaa cgacgcccag caagcgacgg tgatggcgaa ggtcctcgaa
     1681 gaggagcgat acatcggcgc cgacgaggcc gcgctcctct acgttgacaa cgccttcggc
     1741 accggactcg cggacgaaat cgagcgaaag gtatcgggaa ccgagacggt tcgagtcccc
     1801 ttcgaggccg gaaacgactc gtacgccgac gaggtcggta cggtgataga cgccggagtc
     1861 gatgcggtcg cgttcgtcaa cgtgcccgga gagaacgcgg tcgtcgagac gctcggcacg
     1921 agcgatttcg agggtcagac ggtgctttcc accggatacg tgaccggaga cctccccgac
     1981 tacatggacg gcatgtacag cgcgtcggtc gcggaggccg atgccgcagg cgaagtcgaa
     2041 ctccgccaga agttgcgtga gttcgcaccg ctgacggcgt tcaccctcca gtgctacgac
     2101 gcgctgttcc tacaggcgtt ggccatcgag cgggctggcg aggccagcgg cccggcgatc
     2161 agcgagaaca ttcgagcggt gtccgggggc aggggacaca ccgtctcggt caacgacttc
     2221 gggcgcgccg tggacctctt cgacgcggga cgcgaagtga actatcaggg cgcgtcgagc
     2281 agcgtcgatc tgaacgagaa cctcgaaccg ctcaacccct acatcgtcca gcgcgtcgag
     2341 aacggcgaac cgaccaaact cgaactccta caggagtcgt acttctccgg aggagacgcg
     2401 gcatgaacgg ccccgaccgc gaacgactcg acgaactcac gactcgaatc gaaagtcggc
     2461 tcccgcgacg gattcgccgg agctacgcgg cgaagttcgg cgcggtactc gtcggagtgg
     2521 tactcctgat gctcgtcgtc ggcctgtacg tccagataca ggctggcgac atcgtcaggg
     2581 aggacacccg cgcacaaatc agcggtgcgg ccaccgacga ggccgaggcg ttgcagaagt
     2641 gggtcaccaa acagcgttcg acgacgcgct tcctcgccga agccgtcagt cgggacatga
     2701 ccaccgccga acgccgggcg ctgttggagc agaaactcat cgacctgccg agcgaagtgc
     2761 aggcgattca ctacgtcgat acggagaccg gcgaaatact tgcaagtaca gacgacgatg
     2821 cgatagggac gacgcccgcg gggtcgcagg ccagttgggc gggcgggtcg ctctcgttcg
     2881 agggtcctag cgaagtcgtc gtcaccgacc cgtacgaggt cggcgacgac cctgtcgtcg
     2941 ccttcgcgac gccgaccgac cggtccggac ggatgctcgt cgtgaccgcg tcgctcgcca
     3001 agcggtccca cgcgctctcc tcgccgatgg cgaccggcga catcaaagtc gtgaacgaag
     3061 acgaaaccat cgtcttcgac aaccgcaaca gccgactgtt ggggacgtac gagcgcgatt
     3121 cgagcgtcgt cgagaaggga ctcgtcggtc agagcggcgt cagtgacatg ccgctgctcc
     3181 cgctgttcga ccgcggcgga gaggtccggg cctacacgcc ggtcgtcggc accgactggg
     3241 tactcctcta tcacgttccg acgagcgacg cgatggcggt gcagacgaag gtcacggaga
     3301 acgtggtcct gatagtaatc gccgcggtgt tgggcttggc gctggtcggc ctcactatcg
     3361 ggcgcggcac cgccaagtcc ctcgaacagg tcgcggacac ggccgacgac atcgcgtcgg
     3421 ggaaactcga tgtcgaactc cccgagacca ctcgggagga cgagatgggg cggctgttcg
     3481 ggtcgttcgg ttcgatgcgc gagtacctga acacggtcgc ggaccaagcc gatgcgctgg
     3541 cgaaacagga gttcgacgac cccgtcctcg acgagccggt tccgggcacg ttcggcgagt
     3601 cgctcgaacg gatgcgccac gacttagagg agatggtcac gaacatcgac gccgcccgcg
     3661 aggaggccca gagcgccaag gccgaggccg aggagacgaa cgccgcgctc gaacggaagg
     3721 ccgccgagtt cggtcgcgtg atggaacggg ccgccgacgg cgacctgacc cagcgcatgg
     3781 acaccgagag tcccaccgaa gcgatgaccc agatcgccga ggagttcaac gcgatgctcg
     3841 cggaactcga agccacggtg gcggatgtca gtcagttcgc ggagaccgtc gcggcgtcga
     3901 gccaagaggt gaccgcgagt accgccgaga tagaggacgc gagccaacag gtgagcgaat
     3961 cgacgcaggt gatgtcgtcg gccgcggaag accagtccgc ccgcctcgac agaaccgccg
     4021 gggagatgaa cgacctctcg gcgaccatcg aggaggtcgc cgcgtccgca gagcaggtcg
     4081 cgaaggcggc gactcacacc gagtcgttgg gccaacaggg tcgcgaggcc gcacaggaag
     4141 ccatcgacga gatgcgacgc atcgaggacg gaaccgaatc gaccgtccag cagatggagg
     4201 agttagaggc cgaaatcgcc cacatcggcg aggtcgtgga cctcatccgg tctatcgccg
     4261 accagacgaa catgttggcg ctgaacgcga acatcgaggc ggccaacacc gacgagtcca
     4321 gcgacgggtt cgaggtcgtc gcgaacgagg tcaaggccct cgcagacgag acgaaggaag
     4381 cggtcggcga catcgacgac cgcatcgagg ccatcgagtc cggagcgacc gagaccgtcg
     4441 aagacatccg ggagacgcgc gacgccgtct ccgagggggt ccggacggtc cgcgaggccc
     4501 aagaggcgct agagaaggtc gtcgacaacg tcgaggagac gacggacgga atccgcgaaa
     4561 tcagcgacgc gaccgacgac cagtcgatga cgacccaaga ggtcgtcggg atggtggacg
     4621 aaatcacgga tatcagcgac gacaccgccg acgaggccac cgacatcgcc gccgcgaccg
     4681 aggagcagac ggcgtcgctc aaggaggtct ccagaagcgc ggaagaactc tcggagcggg
     4741 ccgaggcgct cgcggccacg gttgaccagt tcgaggtggg ccacgaggac gagcgggtct
     4801 cccaacggac tgactcgccg ccgtctcgct aacgccccgt tctcgggggg cgaaccgtcc
     4861 gtctatcgcg ttcgatttcc acgccgcaag ccagcaaaat tccgcccgag tccgctttat
     4921 ctgagcgcat ctgtccgagg ataacaaccc ttaacctccc atcgtacgcg ttcgtggata
     4981 gaatgagttc cgtcttcacc gacgaagacc gtcgcgaaat cgccgggcgc gcgcggacgc
     5041 tcgcggagcg cctcgacggc ccggccaacg tcgccgagga gtcgccacct atcgaccccg
     5101 agcgcgtcct cgacgagtgg cgagcgacgt ttcccgacga ggagtccttt cgggcgcgac
     5161 tcgcgcacga ggacctcacc gaggagaccg tgcgcgaaca catcgcggcg acgcgatggc
     5221 ccgccgacga accgctcccc gactggatag accgcttgtc gaggctcgtc ggccgcgtcg
     5281 agtcgagtac cgaagccgac cgggacgccg cggcgacccc cgacgagacg ccgttcgagg
     5341 agttgctcgc cgcggtcgtg agcgtcgccc gcgagggggt agccgtcgat tcggtcccgg
     5401 tggagacgat ttcgtcgctg gagcgccaac tcgcggagcg actcgaatcg ctgtgcgtcc
     5461 ggccgctgta cgtcgagttc aagagcttcg tggagcatca cgaccccgaa ctggcggcga
     5521 cgagtcccga cgaggtggcc gacccgccga ccgactacta cgagcggttc gtcgcggcga
     5581 tgttcgacgg cgggttccgg agcctctgtc tggagtaccc cgtcctcgcg cgccagttgg
     5641 tgtcgctcgt cggcgactgg cgggaggcgg tcgaagaact ctgccgacgc gtggcggccg
     5701 acagcgacgc tctgcgcgac gagttcgacg ttcgaggcga cgtgaccgac ctcgacgcgc
     5761 tcgccgcgga cgcccacgct ggcggccggg tcccggttcg ggtcgccttc gaggagggcg
     5821 cggtcgtcta caagccccgg ccggtcggcg gcgaggtcgc gttctacgag attctcggcc
     5881 gtctggacga ccacctctcg acgcccgact tcgactcgcc gacgctcctc gaacgcgagg
     5941 ggtacggctg gatggaactg cgcgagtacc gcgacctctc cgaccagtcg gccgccgacg
     6001 agtactacga gcgcgccggg gccgtcctcg gtctggcgta cctcctcaac ttcaccgact
     6061 gtcactacga gaacgtcgtc gccgagggcg acgcgccgac gatactcgac ggcgagacgg
     6121 tctttcaccc ccacgtcgag tccgaggcca agcccttcga gaccgaggcc agcgccgtgg
     6181 tggaccggtc ggtcctgctg tcggtgctgt tgccgttctc ggtcggggac ccgcgggccg
     6241 accgcggcgg ccggttcgcc gacaaggtgg ccggactcgg gagcgacggc gacgagacgc
     6301 cgctccccgg caagtccgaa ccgaccatcg aggcggtcgg gacggacgtg atgagcgtcg
     6361 agatggaacc ggtgacggtg gacccgagcg agaacacgcc ctccatcgac gggaccgacc
     6421 tgccgcccga ggagtccgtc gatgccctcg tcgccgggtt cgaggagacc tacgagacgg
     6481 tccgggacct ccacgacgag gggcggttcc tcgcagacat cgccacgccc gaactggtcg
     6541 cgggcgtcga gacgcgactc ctctatcgct cgaccggtcg gtacgccgaa ctcctccggt
     6601 cgacggcggc ccggaacccg ctccgggacg gcgcgcgcct gaccgtcgag ttcgaggagt
     6661 tggcggtgcc gttcttcgac ggaaccgtcg agtccgaccg gctctgggag ctgtacgacg
     6721 ccgagcggcg ctcgctccgg aaactggacg tgccgcggtt cgcgtcgcgg gccgacgagt
     6781 cgagcctgtt ccaccgcggc gaacgactcg acgcgacggt ggaccgcacc ggctacgagt
     6841 tcgtccgcca gcgactcgac gcgatggacg atttcgacca gcggcgacag tcgtggctga
     6901 ttcgggaggc ggtcggcgag gtcacgaccg ccgaggggcc gccgccgtcc ggcgacgaag
     6961 ccaccggaag ggacgggaac ggggacagaa acgggaacgg gtctcgccgg gacgaccgct
     7021 tccggcggga agccatcgac ctcttcgagg aggccgccga cgcgcgggtc gaggcgaccg
     7081 acgagccgag ttgggtctcg atagtcccgg agtcgggaat caacctctac ccggccgacg
     7141 actcgctgtt ctggggtcga ggcggcgtcg cgctgaccgc ggccgcgctg gccgacgaga
     7201 ccggccggga ccgctaccgg cgactcgccg acgagacgct ggcccccgtg gtcgagcgaa
     7261 tcttcgaagg gagcgtcgag ttcgaccacg gcgggatgca gggcatcggc tcggtcgtct
     7321 acgtcctctc ggtggtggcg gaactcctcg gcgacgaccg ctaccgggag gccgcgctcg
     7381 ccgcggccga gaccgtcacg tccgagcgcg tcgccgaggc cgacaccttc gacgtggttg
     7441 acggcgtggc ggggacgcta ctgggcctgc tggcgtacta cgagcggtac ggagatgaag
     7501 accgtagcgg agacggtggc gacgaggagg gcggcgacga tggcgacgcc agccccgata
     7561 tcctgcggcg cgcggccgac tgcggcgacc gactgctgga cgctcgaacc gaggtggacg
     7621 gctaccgcgt ctgggagacg accagcgacg acgtgcccta caccgggttc gcccacggct
     7681 ccagcggcat cgcctacgcg ctcgcccgcc tcgccgcggc gaccgacgag gatgccgacc
     7741 gaaatggcaa cgccgaccga aatggcaaca ccgaccgaga cggcaacact gaccgagacg
     7801 gcaacgccga ccgatacgcc gacgcggttc gagaggcgct ggccttcgag tcgtcgctct
     7861 acgacccgtc acggaccaac tggcgacagg ccgcgacccg cgagacctac caagaccgct
     7921 ggtgtcacgg ccgcacgggg atggcgctcg cccgaatcgg tatcggcgaa ctcctcggcg
     7981 acgacgcgct ggtcgcggac gcccgcgagg cgctggccgc gaccgcggcc gacgacgggg
     8041 cgtcgctcga caatctctgc tgcgggaact tcggccgggt cgaagccctg ctggtcgggg
     8101 cgcgccgcgc cgggtgcgac gacgcgctcg cgggtgacct cgccgggcgg tgtctcgcta
     8161 gacgcgagcg cgacggtctc ctctcactgc ccgcccacga ctcggcgttc gtgaacccga
     8221 cgttcttcga cggagtttcc gggccgtcgt acacgctact tcgcctgcgg aacccggaaa
     8281 cgctcccgtc cgtcctcttg ctggagtgac ggcgcgggag cgcgtacccg ctacaaataa
     8341 gactaaacaa gatacataaa tcaataaatt tagaaatgat ataaatattg gaatatattc
     8401 taggttattc accatgaata tttagatttt ttagagttaa taatagaaaa ttctcacaaa
     8461 aagatttaac agtagagagt ccgtcgaaaa catctgcaat gtcagttgca atcgaagccg
     8521 acgccggtag caaggaacag tacgacagcg agttcaccgt cgagaccacc gaggacgtgc
     8581 cggagcagga agccggtcac cgcgacggat gcggcttcac gtgcagtccg ttctccagct
     8641 ggtaacaccc gaaacgactc ttcgtttttt accgctgatc gggacacgag acccgcgaga
     8701 taccgtcggg tcgtcgcgta accacctgcc tcggagccgt gtccgcggcc agtccagccg
     8761 tagttcgaga ccgacgagcc gtgactcgaa ggttcttgaa cgaagtacag tgaccgaatg
     8821 gagttctcga tagcggtcgg actgagaagc gggcgcacac gtctcgaaac tacctgacgg
     8881 gaagctgtca cgacggtcgc ttcgtcgaag cccaactcgg cctgccacaa cagtcacccg
     8941 ttctcggccg ctatccaaca gcgaatgacc acccaccacc tcgcctcgtg gctcctgaaa
     9001 cacagcgacg ttccggtcac ggtcctcaag cccgtggcca ccagactcgg cgtctcgacc
     9061 aactacctcg gcgcggcgct gttcgcgggg caactcgtct acgagaatca ggagaccatc
     9121 gtcaagtacg ccgaccgagg aggcgtccgg gtgggcgggt tcctgcaccg cagagcggtc
     9181 gaacgctacg gcgaggacca cgcgctgact cagcacctcg gcgagaacgt cgcggcgctg
     9241 gacgaagcct tcgaggggac cgaggaggaa gctgtcacgt tcgcggagtt ctatcggcga
     9301 ctccgggcgg tggaccgcga cgcgccccga ctcacgccac cggcggaact cctcgacgcc
     9361 gacttgcccg acgcggacct gcccgacgcg aggctccccg acgacgcgat gccggacgtt
     9421 gatttctccg acgagcgatt gccggacgtg gacctccccg acggccgact cccggacgtg
     9481 gacgtgtcgg gggtcctcgg cggcgcgacc gccgcggtcg ccgaccagcg cgaccgcctg
     9541 cgggacctgc ggcccgactt cggggacgac gctgacgacg agagcgaccc ggtcgagatt
     9601 ccggtccgcg acgaaaactg accacatcta ttctcaaacc gtttacatcg ttttgggaag
     9661 cgtatcctcg attccctcga ctcgaccgaa ccgactggac ccgacccctc gccggttcgc
     9721 cgcgcgcggt cgaacgggag aactaagttc cggaccggcc atcctcggga cgatgacctc
     9781 ctcgcgtgcc gaccgcgccg ggcgaccagc gaccggagac tcctcgggga gactccggac
     9841 cgcggactgc accgaccgac cccggaccgc ggaccgcacc gatcgactcc cgaccgccga
     9901 cgcgccgcac cgatgaagtc tcccgaacac gccgcgctcg ggagcgtcgc ctcgctactc
     9961 ctcgtcgcgg cgcttcccat ctcgataccc gtcgaagccg cgctgctggt cgcgtacggc
    10021 gtcctgctct cggtgttcgt ggacctcgac cacttcgtcg tcgcgcgcta cctcgcgggc
    10081 gactggtcgc acttccggcg gtgcgtcgcc gaccccaagt tcgcgttcac cgagcaggag
    10141 tcggtgttcg acggcgtgga cacccagacg ctggagacgc ttcgcctgct gagtcacctg
    10201 cttctgggcg gcgcgtgggt cggtctcctc ggactggtcc gaccggtcta cgcgctgttt
    10261 accgcgggcg tcctctacgt tcacgtcgtc gccgaccttc tgcgggacgc ggacgtggcg
    10321 tgactcgtac cagtttcgtc ccgaactgaa gctttaaccg accgcggaaa ccatccccga
    10381 cagatgactg gcgggtcccg cttgccgggg acgcccgacg acgacgagac cggcgacccc
    10441 atcgtcctcc atgtggacat ggactgcttc tacgcggcct gtgagcggcg gcgcgaaccg
    10501 cgactggagg gcgaacccgt cgtggtcggg atgggctacg agggcggcga gacccacggc
    10561 gcggtcgcca ccgcgagtta cgaggcccgc gagtacggcg tggacagcgc gcaagccatc
    10621 tcgactgcac tggagcgact gccgcggaag gcggcggtag cggccgagaa tggcgaggat
    10681 tccgaccgac ccgccagcga cgtggacccc gaggaggcgg gttactaccg gccggtggac
    10741 atggactact acgaggaggt cagttcggag gtcaaggaaa tcctccacga gtcggccgac
    10801 gtggtgcggg aggtcagcat cgacgaggcg tacctcgacg tgaccgaccg gaccgcgtgg
    10861 gaggtcgccg aggggttcgc ccgccacgtc aaacaccgca tcgaccgcga agtcggcgtg
    10921 accgcgagcg tcggcgtcgc gccgaacatg tccgccgcga aaatcgccag cgaccacgac
    10981 aagcccgacg gtctcgtcgt ggtcgaaccc ggcgaagtcg gggactttct ggcacccctc
    11041 gacgtgggcg agattcacgg cgtcggcccc gtcacggccc gcaagttgcg cgggatgggc
    11101 atcgagacgg cggcggacct cgcggttgcc gaccgcgcgg agttggaagc gcgattcggc
    11161 gagcgcggcg cggagatgca ccgccgagcg cgcggcgaag accgacgcga ggtcacaccc
    11221 acgggtcgcc ccaagagcct ctcgcgggag tcggcgttca ccgaggcgac cgacgacgac
    11281 gagcgcaagc gcgaccagat tcgaacgttg gcggaggcgg tggccgaccg cgcccggcgg
    11341 aagggcgcga tgtaccgcac catcggtatc aaggccgtca cgccgcccta cgacgtgaac
    11401 acccgcgcga agtcgttgcc cggcccggtg gacgaacccg aactggtcga ggaggtcgcg
    11461 ctcgaactcc tcggcgagtt ttccggcgtc gaggtcagga aggtcggcgt ccgggtctcg
    11521 aacctctcct ttgccgacgg cgagcaggcg agtctgggcg acgcgtgggg gtcgagcgga
    11581 gacgatgccg aacgggccgc gagcgaggcc ccgaatccgg aggacgacgg acaggcttcg
    11641 ctcggtcggc agtgggacga cgattctgcc tccggtgaca acgacgacga ttccggcggc
    11701 gactcggcca gcgaacctcc cgcgagcgac ctcgacggtc aactctcgct ggcccgcgag
    11761 tgggacgtgg cggacgacgc gtccggcgag ttggccgtga acgacgccga agagacggac
    11821 tcggacggaa ccgaccccga ccaacgcgac gagtcggacc ccgaggggca ggtgtcgctc
    11881 gacgacttcg ggtagtcttc gacgcgaatc tcggttgccg gaccggcgcg cggtggcggt
    11941 gcggggcggg gcagtgcggt gctgtgcggc gactcctttg ttcaagcctg tagctagctc
    12001 ctcgacactc tcctcggtca ctccgaaatt tccgagatta ctcgactttg tgaggttttc
    12061 gggctacccg cccgttccga gacttcgccg actcacctcg ccgcgccgcg atacttcgcc
    12121 aactccgccg ccaactcccg attcttcagc aggacgaatc ccgcgacgac cacgccgaac
    12181 ccgaccagcg tcgaggagta caccggttcg tccagcaacc accacccgac ccccaccgag
    12241 accaccggca cgaggtagga gaccagattc acctccagcg ggccgacccg cgacaggagg
    12301 tcgaagtaga cgacgaagcc cacgccgctg gcgaacaccg cgaggtaggc caccgcgagc
    12361 agggccggga gcgcgagtcc ggcgacgggg acctcctcgc cgagcgcgag gctcaggccc
    12421 gcctgtatcg ccgcgcccac cgccatcgcc gcgccggtca gcgagacggt gggcatcgac
    12481 ggcctgaacc gccggaccag caccgtgccg agggtgacgc tcaccgccgc cgcgaacacc
    12541 agcgccggac cgaggagcgc ggtggcgaac gcgccgagtt cgagcgaacc atcgccgacc
    12601 gcggcgctcg cgcccgcgtc gccaccgagc gtcgcggggt cgggtccgac cacgatggcg
    12661 acgccgagga accccacgac caacccgagc gcgccgcgag gagagacggt ctcctcgggg
    12721 agcaggatag cgccgacgag gacggtcaga atcggaatcg cgctgaagac gatcgccgcg
    12781 actccggcgg tcgtgaactg ctggccgacg aaggtcagac cgctcccgcc gatgaagaag
    12841 acgccgcccg cgaggaccgc cagccagtcc gcccgcgtcc ggggccgcca gtagtcggtc
    12901 gtggcgagcg cgtagccgag gagaagcgcc gcggagacgg cgtagcgcac cgccgcgagc
    12961 gccagcggcg ggaggtaacg gaggccgacc tcgatggcgg gaaaggctcc gccgaacagg
    13021 agcgtcat
//
