BGC0002703 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002703 (Halorussus salinus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	23,327	High	archalan α	ribosomal:RiPP

BGC0002703 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 1 - 23,327 nt. (total: 23,327 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 23,328
Label		BGC0002703

Tailoring functions

Lyases: cyclase

EPL00_RS07790: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002703.2	0.92	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002704.2	0.42	ribosomal	archalan β	Halorussus salinus
BGC0000504.5	0.42	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002699.2	0.41	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000517.4	0.37	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002703.2	0.92	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002704.2	0.42	ribosomal	archalan β	Halorussus salinus
BGC0000504.5	0.42	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002699.2	0.41	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000517.4	0.37	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for EPL00_RS07790

allorf_00227_00364

Leader:

MARRASARRPSARDSSADCARRAATFGS

Core:

CTPTTSRGTPTAGCTSA

Core with dehydrations:

CysDhbPDhbDhbDhaRGDhbPDhbAGCysDhbDhaA

antiSMASH-DB 4.0 matches for allorf_00227_00364

25.0%

NZ_MQUS01000030.1:

Lanthipeptides: allorf_005405_005560_lanthipeptide

SRGTPTAGCTSA

S G+P GCT+A

SWGSPNCGCTTA

18.4%

NZ_CP084237.1:

Lanthipeptides: RES5_RS11640_lanthipeptide

RGTPTAGCTS

RGTPT G S

RGTPTIGIAS

MIBiG 4.0 matches for allorf_00227_00364

13.5%

BGC0001229.4 (SBI_06989)and 1 other:

BGC0002110.3 (QKV49894.1) Lanthipeptide: birimositide

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

PTAGCTS

PT CTS

PTTKCTS

allorf_01006_01122

Leader:

MSDFETYTCENCGDEFKAQESANAA

Core:

DESYCSPKCQTAA

Core with dehydrations:

DEDhaYCysDhaPKCysQDhbAA

antiSMASH-DB 4.0 matches for allorf_01006_01122

100.0%

NZ_ML974127.1:

Lanthipeptides: allorf_1546009_1546125_lanthipeptide

DESYCSPKCQTAA

85.7%

NZ_CP096658.1:

Lanthipeptides: allorf_3178073_3178228_lanthipeptide

DESYCSPKCQTAA

+ESYCSPKCQTAA

EESYCSPKCQTAA

23.7%

NZ_CP119804.1:

Lanthipeptides: allorf_0774884_0775030_lanthipeptide

DESYCSPKCQTAA

+ YCSPKCQT A

ENGYCSPKCQTTA

with 24 more sequence matches

Only the first 10 are displayed here.

23.3%

NZ_CP086322.1and 1 other:

NZ_NDXL01000003.1 Lanthipeptides: B7024_RS31125_lanthipeptide

Lanthipeptides: K9S39_RS23570_lanthipeptide

SYCSPKCQTAA

S C+P C TAA

SLCTPGCVTAA

21.9%

NC_014479.1and 9 others:

NZ_CP026362.1 Lanthipeptides: BV11031_RS00400_lanthipeptideNZ_CP033052.1 Lanthipeptides: D9779_RS17315_lanthipeptideNZ_CP051464.1 Lanthipeptides: HC660_RS17030_lanthipeptideNZ_JALAKK010000002.1 Lanthipeptides: MOB09_RS02800_lanthipeptideNZ_JALAKO010000014.1 Lanthipeptides: MOB26_RS08535_lanthipeptideNZ_JALAOG010000003.1 Lanthipeptides: MOC96_RS02500_lanthipeptideNZ_JALAPG010000043.1 Lanthipeptides: MOC70_RS16815_lanthipeptideNZ_JALAQI010000009.1 Lanthipeptides: MOD13_RS06065_lanthipeptideNZ_NXEM01000027.1 Lanthipeptides: CPT06_RS15285_lanthipeptide

Lanthipeptides: BSUW23_RS16845_lanthipeptide

DESYCSPKCQTAA

ES C+P C T A

SESLCTPGCVTGA

20.8%

NZ_CP007699.2and 8 others:

NZ_CP048882.1 Lanthipeptides: G4Z16_RS06545_lanthipeptideNZ_CP048882.1 Lanthipeptides: G4Z16_RS06545_lanthipeptideNZ_FMHI01000015.1 Lanthipeptides: H180DRAFT_RS21560_lanthipeptideNZ_JADDUE010000020.1 Lanthipeptides: INP57_RS28495_lanthipeptideNZ_JAMTCQ010000009.1 Lanthipeptides: LY41_RS11610_lanthipeptideNZ_KB905819.1 Lanthipeptides: F603_RS34750_lanthipeptideNZ_LIVZ01000011.1 Lanthipeptides: AMK31_RS29125_lanthipeptideNZ_LIXJ01000007.1 Lanthipeptides: AMK22_RS13160_lanthipeptide

Lanthipeptides: T261_RS08380_lanthipeptide

SYCSPKCQT

SYC+P C +

SYCTPGCTS

20.7%

NZ_CP101621.1:

Lanthipeptides: NN913_RS16125_lanthipeptide

DESYCSPKCQTAA

+S C+P C T A

SKSLCTPGCITGA

20.0%

NZ_CP034587.1:

Lanthipeptides: EKH77_RS16870_lanthipeptide

SYCSPKCQTAA

S C+P C +AA

SLCTPGCPSAA

18.8%

NC_016047.1and 2 others:

NZ_KZ848487.1 Lanthipeptides: DSL71_RS15965_lanthipeptideNZ_MUXL01000003.1 Lanthipeptides: B0W20_RS12275_lanthipeptide

Lanthipeptides: GYO_RS39160_lanthipeptide

DESYCSPKCQTA

ES C+P C T

SESVCTPGCVTG

18.8%

NZ_CP021903.1and 20 others:

NZ_CP023409.1 Lanthipeptides: Bateq7PJ16_RS18530_lanthipeptideNZ_CP026036.1 Lanthipeptides: C2H93_RS15000_lanthipeptideNZ_CP028218.1 Lanthipeptides: C7M30_RS14555_lanthipeptideNZ_CP035167.1 Lanthipeptides: EQJ08_RS17140_lanthipeptideNZ_CP035226.1 Lanthipeptides: EQW70_RS18175_lanthipeptideNZ_CP045006.1 Lanthipeptides: F9B13_RS03875_lanthipeptideNZ_CP076083.1 Lanthipeptides: KFF76_RS16710_lanthipeptideNZ_CP079759.1 Lanthipeptides: KXZ66_RS17780_lanthipeptideNZ_CP080508.1 Lanthipeptides: K0V03_RS06525_lanthipeptideNZ_CP089148.1 Lanthipeptides: LRO88_RS19055_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04985_lanthipeptideNZ_JALAVX010000009.1 Lanthipeptides: MOE40_RS09385_lanthipeptideNZ_JAMYDW010000007.1 Lanthipeptides: NHM07_RS16180_lanthipeptideNZ_JAQOXM010000001.1 Lanthipeptides: PO770_RS03875_lanthipeptideNZ_NJRD01000003.1 Lanthipeptides: CE053_RS07200_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18435_lanthipeptideNZ_SORJ01000001.1 Lanthipeptides: BJ795_RS01490_lanthipeptideNZ_VFNF01000001.1 Lanthipeptides: FB592_RS01525_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03850_lanthipeptideNZ_VLJL01000012.1 Lanthipeptides: L604_RS09425_lanthipeptide

Lanthipeptides: CD007_RS17065_lanthipeptide

DESYCSPKCQTAA

ES C+P C T

SESLCTPGCVTGV

18.8%

NZ_CP025079.1and 3 others:

NZ_CP047644.1 Lanthipeptides: GNE05_RS17275_lanthipeptideNZ_CP099859.1 Lanthipeptides: NIZ95_RS16280_lanthipeptideNZ_CP101621.1 Lanthipeptides: NN913_RS16115_lanthipeptide

Lanthipeptides: BVQ_RS17705_lanthipeptide

DESYCSPKCQTAA

ES C+P C T

SESVCTPGCVTGV

18.8%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

DESYCSPKCQTAA

+S C+P C+T A

SKSLCTPGCKTGA

18.2%

NZ_CP085954.1:

Lanthipeptides: LK411_RS13585_lanthipeptide

ESYCSPKCQTAA

+S C+P C T A

KSLCTPGCPTGA

MIBiG 4.0 matches for allorf_01006_01122

17.6%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

SYCSPKCQTAA

S C+P C+T A

SLCTPGCKTGA

allorf_01104_01187

Leader:

MSDGGVNGT

Core:

AAAFRLVTRWGCSSALRR

Core with dehydrations:

AAAFRLVDhbRWGCysDhaDhaALRR

antiSMASH-DB 4.0 matches for allorf_01104_01187

26.3%

NZ_AQRJ01000070.1and 1 other:

NZ_LFBV01000003.1 Lassopeptides: AB852_RS38635_lassopeptide

Lassopeptides: YW7_RS36155_lassopeptide

TRWGCSSAL

T WGC + L

TPWGCPNDL

13.9%

NZ_CP061033.1and 1 other:

NZ_CP061033.1 Lanthipeptides: allorf_2077498_2077734_lanthipeptide

Lanthipeptides: allorf_2077498_2077734_lanthipeptide

RWGCSSALR

+WGC+S R

QWGCTSHTR

11.3%

NZ_SLWS01000003.1:

Lanthipeptides: allorf_187044_187256_lanthipeptide

RWGCSSALR

R GC++ALR

RLGCTTALR

allorf_18426_18584

Leader:

MVNITVSKKSTNFYTPERTTSATS

Core:

KSTPNTPSGWPRSRWRTTCPSSSTCRGT

Core with dehydrations:

KDhaDhbPNDhbPDhaGWPRDhaRWRDhbDhbCysPDhaDhaDhaDhbCysRGDhb

antiSMASH-DB 4.0 matches for allorf_18426_18584

32.1%

NZ_CP013140.1:

Lanthipeptides: allorf_2670844_2670996_lanthipeptide

PRSRWRTTCPSSSTCRG

PRSR T C + CRG

PRSRPCTPCVRAGACRG

25.0%

NZ_JAQEAZ010000004.1:

Lanthipeptides: PGT18_RS05860_lanthipeptide

TPNTPSGW---PRSRWRTTC

TPN P+G+ P+++ TC

TPNCPTGFLCPPKTQLTCTC

21.9%

NZ_CP022753.1:

Lanthipeptides: CDO52_RS03850_lanthipeptide

WRTTCPSSST

W TTCPS++T

WGTTCPSANT

with 5 more sequence matches

21.9%

NZ_CP035119.1:

Lanthipeptides: allorf_0901547_0901672_lanthipeptide

RTTCPSSSTCRGT

R TCP S RG

RDTCPDCSVLRGV

18.8%

NZ_KB946318.1:

Lanthipeptides: UAY_RS17335_lanthipeptide

KSTPNTPSGWPR

++TPN+ GW R

ETTPNSLGGWTR

17.9%

NZ_CP076356.1:

Lanthipeptides: allorf_0465057_0465254_lanthipeptide

NTPSGWPRSRWRTTCPSSS

+ W R R+R+ C ++

HFAHNWNRLRFRSYCRYTA

16.1%

NZ_KB235948.1:

Lanthipeptides: allorf_4811775_4811957_lanthipeptide

TPNTPSGWPRSR

TP P GW + +

TPQIPLGWQQGQ

13.0%

NZ_CP031708.1and 3 others:

NZ_CP031708.1 Lanthipeptides: DV942_RS13925_lanthipeptideNZ_FOJM01000003.1 Lanthipeptides: BM107_RS05635_lanthipeptideNZ_FOJM01000003.1 Lanthipeptides: BM107_RS05635_lanthipeptide

Lanthipeptides: DV942_RS13925_lanthipeptide

TCPSSSTCR

TCP++STC+

TCPATSTCK

MIBiG 4.0 matches for allorf_18426_18584

17.9%

BGC0002144.3 (RCCGEPOP_RS37510):

LAP: phazolicin

CPSSSTC

C SSS C

CDSSSRC

14.3%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

STPNTPS

+TP TP+

ATPATPT

allorf_19276_19500

Leader:

MASIGVSSPLASSLDSASADSASVGA

Core:

AALASACSKPPRLACCACSPDCCTCSPVRWPCGACALPPCIAGPPVST

Core with dehydrations:

AALADhaACysDhaKPPRLACysCysACysDhaPDCysCysDhbCysDhaPVRWPCysGACysALPPCysIAGPPVDhaDhb

antiSMASH-DB 4.0 matches for allorf_19276_19500

16.7%

NZ_JVXR01000038.1:

Lanthipeptides: allorf_03771_03965_lanthipeptide

DCCTCSPVRWPCGACALPPCIAGPPV

D + + R+ C LP A PP+

DMFSQNNTRFFLVECLLPLAAASPPL

MIBiG 4.0 matches for allorf_19276_19500

12.5%

BGC0000553.3 (SSGG_RS09925):

Lanthipeptide: SRO15-2212

SKPPRLACCACSPDCCTCSP

S+ L C S C+P

SQVSLLVCEYSSLSVVLCTP

10.4%

BGC0001155.5 (AGY49587.1)and 1 other:

BGC0001155.5 (AGY49587.1) Thiopeptide: GE2270

Thiopeptide: GE2270

CCTCSP

CC+CSP

CCSCSP

allorf_20284_20514

Leader:

MPAAPMAPRRRRRVGIGDRSGGRLINRTARSQSQRLRYRPGA

Core:

TRKRKYEAEELPLRNSPPVSAECGRELRRVRVAD

Core with dehydrations:

DhbRKRKYEAEELPLRNDhaPPVDhaAECysGRELRRVRVAD

antiSMASH-DB 4.0 matches for allorf_20284_20514

27.9%

NZ_CP048405.1:

Lanthipeptides: allorf_3121648_3121833_lanthipeptide

AEELPLRNS-----------PPVSAECGRELRRVR

A LPLR PP + CGR R R

AARLPLRAGVKLPRLSRAAGPPTAGRCGRAGARGR

23.5%

NZ_CP006269.1:

Lanthipeptides: allorf_1792628_1792756_lanthipeptide

YEAEELPLRNSPPVSAEC

YEA+ R SPP + C

YEAQRTRQRKSPPSNGAC

20.6%

NZ_ML974127.1:

Lanthipeptides: EPL00_RS07380_lanthipeptide

PPVSAECGRELRRVR

PP +CG L VR

PPKCPDCGGALTFVR

with 1 more sequence matches

12.5%

NZ_JADMQJ010000021.1:

Lanthipeptides: I2H29_RS15610_lanthipeptide

EAEELPLRNSPPVSAECGRELRRVR

E+ ++P+R S +++ +E+ R+R

ESGDIPVRGSGNYASDEQKEIARLR

MIBiG 4.0 matches for allorf_20284_20514

17.6%

BGC0000580.3 (EGD17354.1):

Lasso peptide: xanthomonin II or xanthomonin I

AEELPLRNSPPVSAE

EE+ N P +S E

GEEIGGFNVPGISEE

allorf_21112_21174

Leader:

MDCVSLSDSSAG

Core:

CSRPSTNR

Core with dehydrations:

CysDhaRPDhaDhbNR

allorf_22147_22221

Leader:

MSDYTKTRRALARPEVAAS

Core:

SSCEG

Core with dehydrations:

DhaDhaCysEG

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

allorf_00227_00364 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 1466.7 Da

Molecular weight: 1467.6 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 1485.6 Da N = 1; 1503.6 Da N = 2; 1521.7 Da N = 3; 1539.7 Da N = 4; 1557.7 Da N = 5; 1575.7 Da N = 6

allorf_01006_01122 - Class II

Cleavage pHMM score: -6.20

RODEO score: 0

Monoisotopic mass: 1347.6 Da

Molecular weight: 1348.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 1366.5 Da N = 1

allorf_01104_01187 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 1966.1 Da

Molecular weight: 1967.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1985.3 Da N = 1; 2003.3 Da N = 2

allorf_18426_18584 - Class II

Cleavage pHMM score: -6.30

RODEO score: 0

Monoisotopic mass: 2877.5 Da

Molecular weight: 2879.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2897.2 Da N = 1; 2915.2 Da N = 2; 2933.2 Da N = 3; 2951.2 Da N = 4; 2969.2 Da N = 5; 2987.3 Da N = 6; 3005.3 Da N = 7; 3023.3 Da N = 8; 3041.3 Da N = 9; 3059.3 Da N = 10

allorf_19276_19500 - Class II

Cleavage pHMM score: -3.30

RODEO score: 0

Monoisotopic mass: 4578.1 Da

Molecular weight: 4581.5 Da

Number of bridges: 7

allorf_20284_20514 - Class II

Cleavage pHMM score: -5.50

RODEO score: 0

Monoisotopic mass: 3926.1 Da

Molecular weight: 3928.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3946.5 Da N = 1; 3964.5 Da N = 2

allorf_21112_21174 - Class II

Cleavage pHMM score: -5.90

RODEO score: 0

Monoisotopic mass: 865.4 Da

Molecular weight: 865.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 884.0 Da N = 1; 902.0 Da N = 2

allorf_22147_22221 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 445.1 Da

Molecular weight: 445.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 463.5 Da N = 1