BGC0002704 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002704 (Halorussus salinus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	23,297	High	archalan β	ribosomal:RiPP

BGC0002704 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 23,297 nt. (total: 23,297 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 23,298
Label		BGC0002704

Tailoring functions

Lyases: cyclase

EPL00_RS20485: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002704.2	1.00	ribosomal	archalan β	Halorussus salinus
BGC0002703.2	0.46	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.42	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001660.3	0.40	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0002699.2	0.38	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0001407.5	0.36	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000598.5	0.31	ribosomal	polytheonamide A, polytheonamide B	Candidatus Entotheonella factor

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002704.2	1.00	ribosomal	archalan β	Halorussus salinus
BGC0002703.2	0.46	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.42	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001660.3	0.40	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0002699.2	0.38	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0001407.5	0.36	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000598.5	0.31	ribosomal	polytheonamide A, polytheonamide B	Candidatus Entotheonella factor

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for EPL00_RS20485

allorf_16280_16441

Leader:

MGWNAEFRATNGG

Core:

CVSTVGFPPPVSSGVVLSQHVRNLHKNIPSETSSGHETSR

Core with dehydrations:

CysVDhaDhbVGFPPPVDhaDhaGVVLDhaQHVRNLHKNIPDhaEDhbDhaDhaGHEDhbDhaR

antiSMASH-DB 4.0 matches for allorf_16280_16441

100.0%

NZ_SBIS02000011.1:

Lanthipeptides: allorf_226672_226833_lanthipeptide

CVSTVGFPPPVSSGVVLSQHVRNLHKNIPSETSSGHETSR

22.5%

NZ_CP113262.1:

Lanthipeptides: allorf_2442087_2442260_lanthipeptide

VGFPPPVSSGVVLSQHVRNLHK

+G P SSGVVL + L +

LGQPSGCSSGVVLERAGERLRR

18.6%

NZ_CP030771.1:

Lanthipeptides: allorf_09785478_09785648_lanthipeptide

VSSGVVLSQHVRNLHKNIPS

V SG+VL+ H R + P+

VGSGIVLNDHFRKCWVSAPT

with 3 more sequence matches

13.0%

NZ_BJTV01000007.1:

Lanthipeptides: allorf_023321_023548_lanthipeptide

VLSQHVRNLHK

VLS VR+LH+

VLSCWVRDLHR

12.5%

NZ_FOGM01000011.1:

Lanthipeptides: allorf_00061_00258_lanthipeptide

FPPPVSSGVVLSQHVR

FPPP + +L H++

FPPPSRTTAILVYHLK

9.7%

NZ_CP102415.1:

Lanthipeptides: NQK81_RS00170_lanthipeptide

VSTVGFPPPVSSGV

ST+ F P +GV

ASTIAFAQPAGAGV

allorf_18217_18375

Leader:

MIPAASLSADQPVAVALPTTAMTLETIIFP

Core:

ISIAAVGTNLDEGIQKSCKFVE

Core with dehydrations:

IDhaIAAVGDhbNLDEGIQKDhaCysKFVE

antiSMASH-DB 4.0 matches for allorf_18217_18375

100.0%

NZ_SBIS02000011.1:

Lanthipeptides: allorf_228609_228767_lanthipeptide

ISIAAVGTNLDEGIQKSCKFVE

10.4%

NZ_KB905395.1and 1 other:

NZ_KB905395.1 Lanthipeptides: allorf_13012_13248_lanthipeptide

Lanthipeptides: allorf_13012_13248_lanthipeptide

ISIAAVGTNLDEGIQKSCK

+ +A +G N +G +C+

VPLAKLGCNTSDGCGHTCQ

allorf_18405_18611

Leader:

MVSNVTLGPLGMGVLAGA

Core:

EMIRTGLLSSNLPVATVGVIICGSSLVLGYAVARPRQNKPNPDKGENRTG

Core with dehydrations:

EMIRDhbGLLDhaDhaNLPVADhbVGVIICysGDhaDhaLVLGYAVARPRQNKPNPDKGENRDhbG

antiSMASH-DB 4.0 matches for allorf_18405_18611

100.0%

NZ_SBIS02000011.1:

Lanthipeptides: allorf_228797_229003_lanthipeptide

EMIRTGLLSSNLPVATVGVIICGSSLVLGYAVARPRQNKPNPDKGENRTG

20.0%

NZ_ADVG01000001.1:

Lanthipeptides: allorf_1943256_1943423_lanthipeptide

VIICGSSLVLGYAVARPRQN

V++C +SL G ARPRQ+

VVLC-ASLPHGDLQARPRQD

18.0%

NZ_JANCLX010000003.1and 1 other:

NZ_JANCLX010000003.1 Lanthipeptides: NMK44_RS06265_lanthipeptide

Lanthipeptides: NMK44_RS06265_lanthipeptide

LPVATVGVIICGSSLVLGYAV

LP A ++C SSL+ G A+

LPDAAAATVLCASSLLCGSAL

with 1 more sequence matches

12.0%

NZ_CP026029.1:

Lassopeptides: C2I18_RS15915_lassopeptide

GYAVARPRQNKPN

G+A+A QN P+

GFAIADSFQNDPD

allorf_18601_18684

Leader:

METIVFS

Core:

SRHEGNYPPCALIVGGLAYR

Core with dehydrations:

DhaRHEGNYPPCysALIVGGLAYR

antiSMASH-DB 4.0 matches for allorf_18601_18684

100.0%

NZ_SBIS02000011.1:

Lanthipeptides: allorf_228993_229076_lanthipeptide

SRHEGNYPPCALIVGGLAYR

27.3%

NZ_BMNG01000001.1and 1 other:

NZ_CP048641.1 Lassopeptides: G3H79_RS13380_lassopeptide

Lassopeptides: IEY91_RS02775_lassopeptide

SRHEGNYPPCALIVG

+R+EG +PP +G

ARYEGGFPPYEWYLG

27.3%

NZ_CP040916.1:

Lassopeptides: FH965_RS40555_lassopeptide

SRHEGNYPPCALIVG

S +EG +PP +G

SYYEGGFPPYEWYLG

with 1 more sequence matches

22.7%

NZ_BNBL01000011.1:

Lassopeptides: IE295_RS25550_lassopeptide

SRHEGNYPPCALIVG

+++EG +PP +G

AQYEGGFPPYEWYLG

allorf_22478_22570

Leader:

MRRAFWRRTRNRFETFGRGYHYG

Core:

SHEVVCA

Core with dehydrations:

DhaHEVVCysA

antiSMASH-DB 4.0 matches for allorf_22478_22570

100.0%

NZ_SBIS02000011.1:

Lanthipeptides: allorf_232870_232962_lanthipeptide

SHEVVCA

allorf_22496_22669

Leader:

MGTVVVPTAEGLEPITGS

Core:

PPEGSAHPSHYLCVLASGQLVAETVGRSNFDGKVGESGA

Core with dehydrations:

PPEGDhaAHPDhaHYLCysVLADhaGQLVAEDhbVGRDhaNFDGKVGEDhaGA

antiSMASH-DB 4.0 matches for allorf_22496_22669

100.0%

NZ_SBIS02000011.1:

Lanthipeptides: allorf_232888_233061_lanthipeptide

PPEGSAHPSHYLCVLASGQLVAETVGRSNFDGKVGESGA

23.1%

NZ_MCIF01000002.1:

Lanthipeptides: allorf_2097064_2097252_lanthipeptide

PPEGSAHPSHY--LCVLA

PP +AHPS LC+L+

PPPSTAHPSSISALCLLS

15.4%

NZ_KV917376.1:

Lassopeptides: BK582_RS26540_lassopeptide

RSNFDGKVGESGA

+NFDGK+ ++ A

NANFDGKINKACA

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

allorf_16280_16441 - Class II

Cleavage pHMM score: -3.90

RODEO score: 0

Monoisotopic mass: 4028.1 Da

Molecular weight: 4030.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4048.5 Da N = 1; 4066.5 Da N = 2; 4084.5 Da N = 3; 4102.5 Da N = 4; 4120.5 Da N = 5; 4138.6 Da N = 6; 4156.6 Da N = 7; 4174.6 Da N = 8; 4192.6 Da N = 9; 4210.6 Da N = 10

allorf_18217_18375 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 2267.2 Da

Molecular weight: 2268.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2286.6 Da N = 1; 2304.6 Da N = 2

allorf_18405_18611 - Class II

Cleavage pHMM score: -1.40

RODEO score: 0

Monoisotopic mass: 5121.8 Da

Molecular weight: 5124.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5142.9 Da N = 1; 5160.9 Da N = 2; 5178.9 Da N = 3; 5196.9 Da N = 4; 5215.0 Da N = 5; 5233.0 Da N = 6

allorf_18601_18684 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 2154.1 Da

Molecular weight: 2155.4 Da

Number of bridges: 1

allorf_22478_22570 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 725.3 Da

Molecular weight: 725.8 Da

Number of bridges: 1

allorf_22496_22669 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 3814.9 Da

Molecular weight: 3817.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3835.2 Da N = 1; 3853.2 Da N = 2; 3871.2 Da N = 3; 3889.2 Da N = 4; 3907.2 Da N = 5