BGC0002706 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002706 (Myxococcus xanthus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	13,879	saframycin Mx1	NRPS:Type I	100%

BGC0002706 - Region 1 - NRPS

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Location: 1 - 13,879 nt. (total: 13,879 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 13,880
Label		BGC0002706

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002706	1.00	NRP	saframycin Mx1	Myxococcus xanthus
BGC0001133	0.37	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.35	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0000426	0.33	NRP	sevadicin	Paenibacillus larvae
BGC0000465	0.33	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000396	0.30	NRP	nodularin	Nostoc sp. 73.1
BGC0002518	0.29	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002135	0.29	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002437	0.28	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0002226	0.28	NRP	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002706	1.00	NRP	saframycin Mx1	Myxococcus xanthus
BGC0001133	0.70	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.68	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0000426	0.66	NRP	sevadicin	Paenibacillus larvae
BGC0000465	0.66	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000396	0.64	NRP	nodularin	Nostoc sp. 73.1
BGC0002518	0.63	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002135	0.63	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002437	0.62	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0002226	0.62	NRP	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 13879:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ala) + (Gly - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

safB

Search NORINE for peptide: strict or relaxed

CAL_domain (57..506): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 30.0
NH2: 22.8
Acetyl-CoA: 5.2
AHBA: 1.0
shikimic_acid: 0.0

AMP-binding (1182..1571): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNNALTYK
Nearest Stachelhaus code(s):: Ala DLFNNALTYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

safA

Search NORINE for peptide: strict or relaxed

AMP-binding (495..885): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGLVWK
Nearest Stachelhaus code(s):: Gly DILQLGLVWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1602..2002): X

nrpys: ohdmTyr

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DPWGLGLIDK
Nearest Stachelhaus code(s):: ohdmTyr DPWGLGLIDK (88% 8Å match); ohmeTyr DPWGLGLIDK (85% 8Å match)
Stachelhaus code match:: 100% (strong)