BGC0002712 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002712 (Actinacidiphila yanglinensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	72,486	High	WS-5995 D/WS-5995 B/WS-5995 C/SEK 43	PKS

BGC0002712 - Region 1 - T2PKS

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Location: 1 - 72,486 nt. (total: 72,486 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 72,487
Label		BGC0002712

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

SAMN05216223_118101: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

SAMN05216223_118105: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

SAMN05216223_11889: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

SAMN05216223_11890: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

SAMN05216223_11891: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

SAMN05216223_11892: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

SAMN05216223_11894: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

SAMN05216223_11899: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase methyltransferase

SAMN05216223_118103: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

SAMN05216223_11888: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Lyases: cyclase

SAMN05216223_118100: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

SAMN05216223_11895: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Ligases: synthase

SAMN05216223_11896: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

SAMN05216223_11897: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002712.2	1.00	PKS	WS-5995 D, WS-5995 B, WS-5995 C, SEK 43	Streptomyces yanglinensis
BGC0000231.5	0.83	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001723.5	0.77	PKS	oviedomycin	Streptomyces antibioticus
BGC0000234.5	0.77	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000235.5	0.62	PKS	kiamycin	Streptomyces sp. W007
BGC0002477.3	0.62	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0000272.3	0.60	PKS	spore pigment	Streptomyces collinus
BGC0002000.4	0.60	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002276.2	0.59	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002672.2	0.58	PKS	saccharothrixin D, saccharothrixin E, saccharothrixin F, saccharothrixin G, saccharothrixin H, saccharothrixin I, saccharothrixin J, saccharothrixin K, saccharothrixin L, saccharothrixin M	Saccharothrix sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002712.2	1.00	PKS	WS-5995 D, WS-5995 B, WS-5995 C, SEK 43	Streptomyces yanglinensis
BGC0000231.5	0.83	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001723.5	0.77	PKS	oviedomycin	Streptomyces antibioticus
BGC0000234.5	0.77	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000235.5	0.62	PKS	kiamycin	Streptomyces sp. W007
BGC0002477.3	0.62	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0000272.3	0.60	PKS	spore pigment	Streptomyces collinus
BGC0002000.4	0.60	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002276.2	0.59	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002672.2	0.58	PKS	saccharothrixin D, saccharothrixin E, saccharothrixin F, saccharothrixin G, saccharothrixin H, saccharothrixin I, saccharothrixin J, saccharothrixin K, saccharothrixin L, saccharothrixin M	Saccharothrix sp.

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 72486
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 692.1; E-value: 4.4e-211)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 398 Da
acetyl-CoA_9: 440 Da

SAMN05216223_118100: CYC C7-C12 (Score: 469.6; E-value: 8.3e-144)
SAMN05216223_118101: OXY (Score: 532.4; E-value: 2.5e-162)
SAMN05216223_118103: MET (Score: 296.2; E-value: 7.1e-91)
SAMN05216223_11889: OXY (Score: 394.0; E-value: 2.5e-120)
SAMN05216223_11890: KR (Score: 168.8; E-value: 4.1e-52)
SAMN05216223_11894: OXY (Score: 598.1; E-value: 2.9e-182)
SAMN05216223_11895: CYC C4-C17/C2-C19 (Score: 190.1; E-value: 8.9e-59)
SAMN05216223_11896: KS (Score: 796.1; E-value: 1.5e-242)
SAMN05216223_11897: CLF 8|9 (Score: 692.1; E-value: 4.4e-211)
SAMN05216223_11898: ACP (Score: 125.7; E-value: 1.2e-39)
SAMN05216223_11899: KR C9 (Score: 467.0; E-value: 3.7e-143)