BGC0002713: mevalagmapeptide A biosynthetic gene cluster from Photorhabdus laumondii subsp. laumondii
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Location: 1,002,026 - 1,054,633 nt. (total: 52,608 nt).
This entry is originally from NCBI GenBank CP024901.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002713
Short description mevalagmapeptide A biosynthetic gene cluster from Photorhabdus laumondii subsp. laumondii
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP024901.1
1002026 - 1054633
via Heterologous expression
Compounds
  • mevalagmapeptide A
  • mevalagmapeptide B
  • mevalagmapeptide C
  • mevalagmapeptide D
Species Photorhabdus laumondii subsp. laumondii [taxonomy]
References
Chemical products information
mevalagmapeptide A Evidence:
(no structure information available)
mevalagmapeptide B Evidence:
(no structure information available)
mevalagmapeptide C Evidence:
(no structure information available)
mevalagmapeptide D Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PluTT01m_04500
  • AXG46145.1
 1002026 - 1002976 (-) tRNA glutamyl-Q(34) synthetase GluQRS
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    • PluTT01m_04505
    • AXG46146.1
    • dksA
    		 1003039 - 1003494 (-) RNA polymerase-binding transcription factor DksA
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      • PluTT01m_04510
      • AXG46147.1
      		 1003690 - 1004397 (-) DNA/RNA nuclease SfsA
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        • PluTT01m_04515
        • AXG46148.1
        		 1004902 - 1005447 (-) CpmK protein
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          • PluTT01m_04520
          • AXG46149.1
          		 1005444 - 1005980 (-) spore coat protein CotH
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            • PluTT01m_04525
            • AXG46150.1
            		 1005970 - 1006785 (-) spore coat protein CotH
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              • PluTT01m_04530
              • AXG49759.1
              		 1006788 - 1007054 (-) DUF1933 domain-containing protein
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                • PluTT01m_04535
                • AXG49760.1
                		 1007344 - 1009833 (+) ATP-dependent helicase HrpB
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                  • PluTT01m_04540
                  • AXG46151.1
                  • mrcB
                  		 1009927 - 1012383 (+) penicillin-binding protein 1B
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                    • PluTT01m_04545
                    • AXG46152.1
                    		 1012868 - 1014541 (+) killer protein of pyocin s3
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                      • PluTT01m_04550
                      • AXG46153.1
                      		 1014541 - 1014993 (+) immunity protein
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                        • PluTT01m_04555
                        • AXG46154.1
                        		 1015075 - 1015527 (+) pyocin immunity protein
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                          • PluTT01m_04560
                          • AXG49761.1
                          		 1015648 - 1016073 (+) HNH endonuclease
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                            • PluTT01m_04565
                            • AXG46155.1
                            		 1016081 - 1016332 (+) bacteriocin immunity protein
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                              • PluTT01m_04570
                              		 1016408 - 1016587 (+) killer protein of pyocin s3
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                                • PluTT01m_04575
                                • AXG46156.1
                                		 1016618 - 1017085 (+) hypothetical protein
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                                  • PluTT01m_04580
                                  • AXG46157.1
                                  		 1017150 - 1017617 (+) pyocin immunity protein
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                                    • PluTT01m_04585
                                    • AXG46158.1
                                    		 1017679 - 1017936 (+) bacteriocin immunity protein
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                                      • PluTT01m_04590
                                      • AXG46159.1
                                      		 1018165 - 1018626 (+) hypothetical protein
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                                        • PluTT01m_04595
                                        • AXG46160.1
                                        		 1018732 - 1019040 (+) hypothetical protein
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                                          • PluTT01m_04600
                                          • AXG46161.1
                                          		 1019192 - 1019521 (+) XRE family transcriptional regulator
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                                            • PluTT01m_04605
                                            • AXG46162.1
                                            		 1019515 - 1020831 (+) type II toxin-antitoxin system HipA family toxin
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                                              • PluTT01m_04610
                                              • AXG46163.1
                                              		 1021624 - 1025130 (+) non-ribosomal peptide synthetase
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                                                • PluTT01m_04615
                                                • AXG46164.1
                                                		 1025127 - 1029860 (+) non-ribosomal peptide synthetase
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                                                  • PluTT01m_04620
                                                  • AXG46165.1
                                                  		 1029857 - 1035886 (+) non-ribosomal peptide synthetase
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                                                    • PluTT01m_04625
                                                    • AXG46166.1
                                                    		 1036027 - 1036311 (-) XRE family transcriptional regulator
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                                                      • PluTT01m_04630
                                                      • AXG46167.1
                                                      		 1036301 - 1036522 (-) hypothetical protein
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                                                        • PluTT01m_04635
                                                        • AXG46168.1
                                                        		 1036623 - 1036886 (+) AbrB/MazE/SpoVT family DNA-binding domain-containing protein
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                                                          • PluTT01m_04640
                                                          • AXG46169.1
                                                          • hemL
                                                          		 1036928 - 1038211 (-) glutamate-1-semialdehyde 2,1-aminomutase
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                                                            • PluTT01m_04645
                                                            • AXG46170.1
                                                            		 1038262 - 1039047 (-) DUF1460 domain-containing protein
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                                                              • PluTT01m_04650
                                                              • AXG49762.1
                                                              		 1039356 - 1039700 (+) iron-sulfur cluster insertion protein ErpA
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                                                                • PluTT01m_04655
                                                                • AXG46171.1
                                                                		 1039789 - 1040616 (-) cobalamin-binding protein
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                                                                  • PluTT01m_04660
                                                                  • AXG46172.1
                                                                  		 1040822 - 1041523 (-) 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
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                                                                    • PluTT01m_04665
                                                                    • AXG46173.1
                                                                    		 1041651 - 1043177 (+) dGTPase
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                                                                      • PluTT01m_04670
                                                                      • AXG46174.1
                                                                      		 1043192 - 1045519 (-) two-component sensor histidine kinase BarA
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                                                                        • PluTT01m_04675
                                                                        • AXG46175.1
                                                                        		 1045573 - 1046889 (+) 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD
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                                                                          • PluTT01m_04680
                                                                          • AXG46176.1
                                                                          		 1046931 - 1049162 (+) GTP diphosphokinase
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                                                                            • PluTT01m_04685
                                                                            • AXG46177.1
                                                                            		 1049230 - 1050009 (+) nucleoside triphosphate pyrophosphohydrolase
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                                                                              • PluTT01m_04690
                                                                              • AXG46178.1
                                                                              • pyrG
                                                                              		 1050231 - 1051868 (+) CTP synthetase
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                                                                                • PluTT01m_04695
                                                                                • AXG46179.1
                                                                                		 1051942 - 1053243 (+) enolase
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                                                                                  • PluTT01m_04700
                                                                                  • AXG46180.1
                                                                                  		 1053559 - 1053753 (+) hypothetical protein
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                                                                                    • PluTT01m_04705
                                                                                    • AXG49763.1
                                                                                    		 1053926 - 1054633 (+) hypothetical protein
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                                                                                      Biosynthesis information

                                                                                      Biosynthetic modules

                                                                                      Name
                                                                                      Unk01
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      PluTT01m_04610
                                                                                      Substrates
                                                                                      valine (evidence: Structure-based inference [1])
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk02
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      PluTT01m_04615
                                                                                      Substrates
                                                                                      valine (evidence: Structure-based inference [1])
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk03
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      PluTT01m_04620
                                                                                      Substrates
                                                                                      valine (evidence: Structure-based inference [1])
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Annotation changelog

                                                                                      Entry version: 1

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2022-09-15
                                                                                      Entry added
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      2022-09-15
                                                                                      Added NRP substrate specificities
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      Detailed domain annotation
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