BGC0002715: HTTPCA biosynthetic gene cluster from Photorhabdus laumondii subsp. laumondii
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Location: 2,700,417 - 2,756,939 nt. (total: 56,523 nt).
This entry is originally from NCBI GenBank CP024901.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002715
Short description HTTPCA biosynthetic gene cluster from Photorhabdus laumondii subsp. laumondii
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
CP024901.1
2700417 - 2756939
via Heterologous expression
Compounds
  • HTTPCA
  • prepiscibactin
  • piscibactin
Species Photorhabdus laumondii subsp. laumondii [taxonomy]
References
Chemical products information
HTTPCA Evidence:
(no structure information available)
prepiscibactin Evidence:
(no structure information available)
piscibactin Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PluTT01m_11855
  • AXG47393.1
 2700417 - 2700857 (-) type VI secretion system baseplate subunit TssE
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    • PluTT01m_11860
    • AXG47394.1
    		 2700912 - 2701406 (-) Hcp1 family type VI secretion system effector
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      • PluTT01m_11865
      • AXG49839.1
      		 2701463 - 2702944 (-) type VI secretion system contractile sheath large subunit
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        • PluTT01m_11870
        • AXG47395.1
        		 2702952 - 2703503 (-) type VI secretion system contractile sheath small subunit
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          • PluTT01m_11875
          • AXG47396.1
          		 2704228 - 2704482 (+) toxin-antitoxin system HicB family antitoxin
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            • PluTT01m_11880
            • AXG47397.1
            		 2704727 - 2705602 (-) DNA-packaging protein
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              • PluTT01m_11885
              		 2706018 - 2706125 (-) VapC toxin family PIN domain ribonuclease
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                • PluTT01m_11890
                • AXG47398.1
                		 2706247 - 2706519 (+) ribbon-helix-helix protein, CopG family
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                  • PluTT01m_11895
                  • AXG47399.1
                  		 2706507 - 2706797 (+) type II toxin-antitoxin system RelE/ParE family toxin
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                    • PluTT01m_11900
                    		 2706888 - 2707019 (-) VapC toxin family PIN domain ribonuclease
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                      • PluTT01m_11905
                      		 2707022 - 2707198 (+) IS1595 family transposase
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                        • PluTT01m_11910
                        • AXG47400.1
                        		 2707235 - 2707513 (-) putative addiction module antidote protein
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                          • PluTT01m_11915
                          • AXG47401.1
                          		 2707510 - 2707812 (-) type II toxin-antitoxin system RelE/ParE family toxin
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                            • PluTT01m_11920
                            • AXG47402.1
                            		 2707910 - 2708050 (+) hypothetical protein
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                              • PluTT01m_11925
                              		 2708043 - 2708231 (-) transposon DNA-invertase
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                                • PluTT01m_11930
                                		 2708221 - 2708310 (-) class A beta-lactamase
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                                  • PluTT01m_11935
                                  • AXG47403.1
                                  		 2709005 - 2710858 (+) polyurethanase
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                                    • PluTT01m_11940
                                    • AXG47404.1
                                    		 2710876 - 2711901 (-) IS630 family transposase ISPlu3
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                                      • PluTT01m_11945
                                      • AXG47405.1
                                      		 2712189 - 2713160 (-) AraC family transcriptional regulator
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                                        • PluTT01m_11950
                                        • AXG47406.1
                                        		 2713457 - 2715463 (+) TonB-dependent receptor
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                                          • PluTT01m_11955
                                          • AXG47407.1
                                          		 2715460 - 2716704 (+) MFS transporter
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                                            • PluTT01m_11960
                                            • AXG47408.1
                                            		 2716697 - 2718496 (+) ABC transporter ATP-binding protein
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                                              • PluTT01m_11965
                                              • AXG47409.1
                                              		 2718483 - 2720243 (+) ABC transporter ATP-binding protein
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                                                • PluTT01m_11970
                                                • AXG47410.1
                                                		 2720286 - 2726435 (+) non-ribosomal peptide synthetase
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                                                  • PluTT01m_11975
                                                  • AXG47411.1
                                                  		 2726435 - 2738161 (+) hybrid non-ribosomal peptide synthetase/type I polyketide synthase
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                                                    • PluTT01m_11980
                                                    • AXG47412.1
                                                    		 2738158 - 2739255 (+) hypothetical protein
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                                                      • PluTT01m_11985
                                                      • AXG49840.1
                                                      		 2739252 - 2740058 (+) thioesterase
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                                                        • PluTT01m_11990
                                                        • AXG47413.1
                                                        		 2740058 - 2742991 (+) salicylate synthase
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                                                          • PluTT01m_11995
                                                          • AXG47414.1
                                                          		 2743184 - 2744350 (+) oxalate decarboxylase
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                                                            • PluTT01m_12000
                                                            • AXG47415.1
                                                            		 2744886 - 2745893 (+) Txp40, insecticidal toxin (previously name A24tox)
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                                                              • PluTT01m_12005
                                                              • AXG47416.1
                                                              		 2746210 - 2747253 (-) acyltransferase
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                                                                • PluTT01m_12010
                                                                • AXG47417.1
                                                                		 2747264 - 2747920 (-) SGNH/GDSL hydrolase family protein
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                                                                  • PluTT01m_12015
                                                                  • AXG47418.1
                                                                  		 2748978 - 2749232 (+) antitoxin
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                                                                    • PluTT01m_12020
                                                                    		 2749269 - 2749537 (+) plasmid stabilization protein ParE
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                                                                      • PluTT01m_12025
                                                                      • AXG47419.1
                                                                      		 2749816 - 2750745 (+) hypothetical protein
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                                                                        • PluTT01m_12030
                                                                        • AXG47420.1
                                                                        		 2750706 - 2751392 (+) hypothetical protein
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                                                                          • PluTT01m_12035
                                                                          • AXG47421.1
                                                                          		 2751654 - 2753417 (-) cytochrome-c oxidase
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                                                                            • PluTT01m_12040
                                                                            • AXG47422.1
                                                                            		 2753942 - 2754256 (+) hypothetical protein
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                                                                              • PluTT01m_12045
                                                                              • AXG47423.1
                                                                              		 2754417 - 2754857 (-) OsmC family peroxiredoxin
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                                                                                • PluTT01m_12050
                                                                                • AXG47424.1
                                                                                		 2755183 - 2755617 (-) DUF29 domain-containing protein
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                                                                                  • PluTT01m_12055
                                                                                  • AXG47425.1
                                                                                  		 2755731 - 2756939 (-) tyrosine transporter TyrP
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                                                                                    Biosynthesis information

                                                                                    Biosynthetic modules

                                                                                    Name
                                                                                    Unk01
                                                                                    Type
                                                                                    nrps-type1
                                                                                    Genes
                                                                                    PluTT01m_11970
                                                                                    Substrates
                                                                                    cysteine (evidence: Structure-based inference [1])
                                                                                    Integrated Monomers
                                                                                    Domains
                                                                                    adenylation
                                                                                    Name
                                                                                    Unk02
                                                                                    Type
                                                                                    nrps-type1
                                                                                    Genes
                                                                                    PluTT01m_11975
                                                                                    Substrates
                                                                                    cysteine (evidence: Structure-based inference [1])
                                                                                    Integrated Monomers
                                                                                    Domains
                                                                                    adenylation
                                                                                    Annotation changelog

                                                                                    Entry version: next

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2024-08-12
                                                                                    MIBiG v4 annotathon
                                                                                    • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 1

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2022-09-15
                                                                                    Entry added
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    2022-09-15
                                                                                    Added NRP substrate specificities
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    Detailed domain annotation
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