BGC0002719: thanafactin A biosynthetic gene cluster from Pseudomonas fluorescens
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Location: 2,458,382 - 2,525,743 nt. (total: 67,362 nt).
This entry is originally from NCBI GenBank JAAOIQ010000001.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
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Biosynthesis
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NRPS/PKS domains
General information about the BGC

MIBiG accession | BGC0002719
Short description | thanafactin A biosynthetic gene cluster from Pseudomonas fluorescens
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- NRPS (Type I)

Loci
JAAOIQ010000001.1
2475547 - 2508857
via
Compounds

- thanafactin A

Species Pseudomonas fluorescens [taxonomy]
References

- [1] Discovery of Thanafactin A, a Linear, Proline-Containing Octalipopeptide from Pseudomonas sp. SH-C52, Motivated by Genome Mining. Kirchner, N et al., Journal of Natural Products (2020) DOI:10.1021/acs.jnatprod.0c01174
- [2] Discovery of Thanafactin A, a Linear, Proline-Containing Octalipopeptide from . Kirchner N et al., J Nat Prod (2021) PMID:33382250

Chemical products information
thanafactin A Evidence:
(no structure information available)
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
G7W60_10795 NHN68321.1 | 2475547 - 2476593 (-) | methyltransferase domain-containing protein |  |  | copy AA seq copy Nt seq
G7W60_10800 NHN68322.1 | 2476882 - 2477043 (-) | DUF2986 domain-containing protein |  |  | copy AA seq copy Nt seq
G7W60_10805 NHN68323.1 | 2477131 - 2477913 (+) | SDR family oxidoreductase |  |  | copy AA seq copy Nt seq
G7W60_10810 NHN68324.1 | 2478382 - 2487930 (+) | amino acid adenylation domain-containing protein |  |  | copy AA seq copy Nt seq
G7W60_10815 NHN68325.1 | 2487927 - 2505743 (+) | amino acid adenylation domain-containing protein |  |  | copy AA seq copy Nt seq
G7W60_10820 NHN68326.1 | 2505727 - 2507049 (+) | MFS transporter |  |  | copy AA seq copy Nt seq
G7W60_10825 NHN68327.1 | 2507085 - 2507282 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
G7W60_10830 NHN68328.1 | 2507501 - 2507842 (-) | carboxymuconolactone decarboxylase family protein |  |  | copy AA seq copy Nt seq
G7W60_10835 NHN68329.1 | 2507952 - 2508857 (+) | AraC family transcriptional regulator |  |  | copy AA seq copy Nt seq

Biosynthesis information

#### Biosynthetic modules

Name
Unk01
Type
nrps-type1
Genes
G7W60_10810
Substrates
valine (evidence: Structure-based inference, Sequence-based prediction)
Integrated Monomers
Domains
adenylation
Name
Unk02
Type
nrps-type1
Genes
G7W60_10810
Substrates
alanine (evidence: Structure-based inference, Sequence-based prediction)
Integrated Monomers
Domains
adenylation
Name
Unk03
Type
nrps-type1
Genes
G7W60_10810
Substrates
glutamine (evidence: Structure-based inference, Sequence-based prediction)
Integrated Monomers
Domains
adenylation
Name
Unk04
Type
nrps-type1
Genes
G7W60_10815
Substrates
alanine (evidence: Structure-based inference, Sequence-based prediction)
Integrated Monomers
Domains
adenylation
Name
Unk05
Type
nrps-type1
Genes
G7W60_10815
Substrates
valine (evidence: Structure-based inference, Sequence-based prediction)
Integrated Monomers
Domains
adenylation
Name
Unk06
Type
nrps-type1
Genes
G7W60_10815
Substrates
alanine (evidence: Structure-based inference, Sequence-based prediction)
Integrated Monomers
Domains
adenylation
Name
Unk07
Type
nrps-type1
Genes
G7W60_10815
Substrates
proline (evidence: Structure-based inference, Sequence-based prediction)
Integrated Monomers
Domains
adenylation
Name
Unk08
Type
nrps-type1
Genes
G7W60_10815
Substrates
threonine (evidence: Structure-based inference, Sequence-based prediction)
Integrated Monomers
Domains
adenylation
Annotation changelog

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2022-09-15
Entry added

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2022-09-15
Added NRP substrate specificities

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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