LOCUS       BGC0002745             30951 bp    DNA     linear   PLN 24-MAR-2017
DEFINITION  Penicillium polonicum strain IBT 4502 PENPOL_contig002, whole genome
            shotgun sequence.
ACCESSION   BGC0002745
VERSION     BGC0002745
KEYWORDS    .
SOURCE      Penicillium polonicum
  ORGANISM  Penicillium polonicum
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Penicillium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 18:19:19
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 30951
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..30951
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[11640:19397]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      11641..19397
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..30951
                     /SMILES="C([*])C(-O)(C)"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..30951
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002745"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..30951
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(229..3363)
                     /locus_tag="PENPOL_c002G07872"
                     /note="pqsH"
     mRNA            complement(join(229..1289,1359..1517,1577..2528,2583..2851,
                     2911..2996,3053..3097,3152..3244,3298..3363))
                     /locus_tag="PENPOL_c002G07872"
                     /product="hypothetical protein"
     CDS             complement(join(542..1289,1359..1517,1577..2528,2583..2851,
                     2911..2996,3053..3097,3152..3244,3298..3363))
                     /codon_start=1
                     /db_xref="InterPro:IPR002938"
                     /db_xref="PFAM:PF01494"
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 213.4; E-value: 1e-64)"
                     /gene_kind="other"
                     /locus_tag="PENPOL_c002G07872"
                     /product="hypothetical protein"
                     /protein_id="OQD69144.1"
                     /transl_table=11
                     /translation="MTFRVIIVGGGVAGLTLASAFEKAGIDYILLECRPAFDVAVGASI
                     ALSPNGARILDQLGAWEKWLKIAQPLVRWGDRNSKGELIMPRSASTPLAKALTGYDMTF
                     GLRRSLLQTLYDNIEDKSMLLPKKSVINVTCSQEGVAVQCADGCSYEGDILVGADGTYS
                     KVREYMWRLADRDEPGLMDPDKKAMTAEYQCLFGISKASGSIAIGDADFIYDHDRSSFI
                     FSDNCGRICYFILQKMDRVYEMVEIPRFSQANAQAYAQRHADIQIRPDLTFGNLYEHSE
                     SSILVALEEAKFKQWSWGRIVCVGDSIHKMTPNLGAGASASIESAAALLNSIKAMFDHS
                     PEEGPTETQIRECFAQYQKSREVRATAIVDASSMTTRLQALRGWFEFLFVRLGMPIMGS
                     FAADMASEIWVGATMLENLAPPKASLRGTLPFNPTQGQGQRESKLKRALLGLPFLALLL
                     VAKTATDAKYASALRGYIWESGGMTSAMGSVPLLQRFYSMKGVGDLWSLRYINYLPDFY
                     ETNYESLSQAVSSSIDVGIVMSIWSFESIRRANALTMAQIPTLFTFYGQMAGLGRVSPL
                     YYILYYINSPIEVFKGADMRLMHLNYAIAVLPAIIVSYYIPLSAAFFWPTVSGRKSWLF
                     VWQMHPIWTAITLYLFSRIFPSTVKEDRVHGLRRDLPVIKFSMTVLVIGAAGFWMWSRW
                     TSPSSVARVFFPTAVPSTQAPFAACVCAILKWDMLSTFGSTFLWLGYLIWDLKYAGMMQ
                     ATWVRVAIYGVAAFVALGPGAAIGLGWLWRENILAHKRHKDAVTEENLAQTR"
     gene            3961..4647
                     /locus_tag="PENPOL_c002G01780"
                     /note="ybcY"
     mRNA            3961..4647
                     /locus_tag="PENPOL_c002G01780"
                     /product="hypothetical protein"
     CDS             3961..4647
                     /codon_start=1
                     /db_xref="InterPro:IPR029063"
                     /locus_tag="PENPOL_c002G01780"
                     /product="hypothetical protein"
                     /protein_id="OQD68888.1"
                     /transl_table=11
                     /translation="MHPSARLYNNIALWFYDYLVHSIFMVYGWHCPTKSVGLPFFSSHV
                     GPKHMDVGVGTGYFPVAVRKSSRKRNGQLKPQWPQKLMLVDLNPNCTAMAATRVGAPDC
                     TETLTADVLQPIPAAGKHETFDSLSLMNVLHCLPGTSESKAQAFGHLKPFLKEDGVLFG
                     STILGRGVEHNRFGRLVMWLSNSLGIFHNYGDHPDDFVRALQKDFNQVEHVVVGRVLLF
                     TAKEPN"
     gene            5739..7016
                     /locus_tag="PENPOL_c002G07909"
                     /note="ABA2_4"
     mRNA            join(5739..6060,6120..6490,6552..7016)
                     /locus_tag="PENPOL_c002G07909"
                     /product="hypothetical protein"
     CDS             join(5739..6060,6120..6490,6552..7016)
                     /codon_start=1
                     /db_xref="InterPro:IPR002938"
                     /db_xref="PFAM:PF01494"
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 132.8; E-value: 3.1e-40)"
                     /gene_kind="other"
                     /locus_tag="PENPOL_c002G07909"
                     /product="hypothetical protein"
                     /protein_id="OQD69870.1"
                     /transl_table=11
                     /translation="MLCWELANRRKRIGPNRFGFPIAILTRQQLIEVLYTALSDKSKVK
                     TGKKVVRIESEERRITTWTEDGSEYEGELVVGADGVHSVTRSEMWRAADNQQPGFIQEE
                     EKYSLSAEYSCIWGLSTPVPGIRQGEQIIRSYDRLTFLIFPSQNGCLGWFAIQKLNRKH
                     VYPDIRPFSQKDTLARCEALRDLPIWNDVKFGDLLTLTEVCAMTPLEENLFQTWNYGRI
                     LCIGDSISKLTPNIAQGANTAIEGAAAVANGLHQLLHHNGLNQPSYDEIQEVLGRYSQS
                     QRKRMKKLHWISHMVTRLQSREGLINKFVGRYIYSHTGNSTFYLTGKMIAQGPVLNYLS
                     TPKEIEIGLRASFDQYGKDGGDMPWKTTIMFIALLTIVVLIYSFI"
     gene            complement(7175..8342)
                     /locus_tag="PENPOL_c002G01858"
                     /note="genemark-PENPOL_contig002-processed-gene-12.25-
                     mRNA-1"
     mRNA            complement(join(7175..7922,7987..8342))
                     /locus_tag="PENPOL_c002G01858"
                     /product="hypothetical protein"
     CDS             complement(join(7175..7922,7987..8342))
                     /codon_start=1
                     /locus_tag="PENPOL_c002G01858"
                     /product="hypothetical protein"
                     /protein_id="OQD69720.1"
                     /transl_table=11
                     /translation="MSTAVNTIRCSLLLLGLVGIYTVWISSFRNGLFLRNEEFAGKGQL
                     PGTPNATLRTHFTGIDTLDKALGIFVVFYWPVCQGNLRSLSLIAFPAAVGVGEMWILFA
                     LQFSQSNSPTRAMGKMAMFGMGLMLVGPGIFLPIYCSLDLSSTHRLDDSPSSAAEGHLC
                     RNLRSCLLGGYYILVILLALPSPAVVSYGSKQGIIALLQGWPLLVSAMLWLTHLCGKDR
                     TADFQATLSTARTSIYISAMACATISHLVPLLISLLADSSDICPGKVFVPHLAWPSRRV
                     TSVEEGLLRFFQWDYGLGSLALLLWAVGLHIQRRQQISQGINYLRLIPEALFLSVMMSP
                     CGAAALYLYRHNSTNCASKTGDKSGSG"
     gene            9014..11030
                     /locus_tag="PENPOL_c002G07307"
                     /note="ordA"
     mRNA            join(9014..9211,9273..9336,9398..11030)
                     /locus_tag="PENPOL_c002G07307"
                     /product="hypothetical protein"
     CDS             join(9109..9211,9273..9336,9398..10847)
                     /codon_start=1
                     /db_xref="GO:0005506"
                     /db_xref="GO:0016705"
                     /db_xref="GO:0020037"
                     /db_xref="GO:0055114"
                     /db_xref="InterPro:IPR001128"
                     /db_xref="PFAM:PF00067"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 199.1; E-value: 2.2e-60)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="PENPOL_c002G07307"
                     /product="hypothetical protein"
                     /protein_id="OQD69071.1"
                     /sec_met_domain="p450 (E-value: 8e-77, bitscore: 248.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVFAMLVVCWSIFLGLWMLVSRLKQSRDKICPPKGPPRLPWIGNL
                     HQFPLKLLHLRLTEWSRTYGGFYTLKLGPVTAAVITDRQIAKEAFDRNSAISSTRHTNY
                     ATEFVTDGTHLLTMKYGALWREERKILQQTLKGSVCDNDHMRLIDAEQTQLMRDLLVNP
                     SDYSAYIKRASTSIITSLVFGIRTPSCATLHLQELDAINDDWLQLLVIGGALSEDVFPV
                     LKYIPSAFLGTFTKRLKGIRRRMRRLYGTMLNQTITRQRESPAPPARSMIDAVLNQREH
                     FNLTDRQIEVLAGVTLEGGFDTTTSMLLVFVQAMTLHPECQERAYVEINALCGRHRIPQ
                     WSDRNQLPYVNMLLKETMRWRPVTTLSPPHVLEKDTTIRGTFLPQGSMLILNTWGLHQD
                     PNVFIDPDRFDPMRYEGYTKLAADYANAPDAATRDHYTYGIGRRICPGIHLADRSMFLA
                     IAKLIWGFRFEPQRDEQGNSIPIDSNPVTGYTVDKVQISPKPFACAVIPRDKEGEKTIL
                     REFGVASEVFADYNLDENASL"
     CDS             join(11641..18188,18245..19397)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (5-441). E-value:
                     8e-167. Score: 547.3. Matches aSDomain:
                     nrpspksdomains_PENPOL_c002G03804_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (553-869). E-value: 6.5e-80.
                     Score: 260.5. Matches aSDomain:
                     nrpspksdomains_PENPOL_c002G03804_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (949-1122). E-value: 3.6e-26.
                     Score: 84.3. Matches aSDomain:
                     nrpspksdomains_PENPOL_c002G03804_PKS_DH.1"
                     /NRPS_PKS="Domain: cMT (1388-1595). E-value: 1.1e-77.
                     Score: 252.9. Matches aSDomain:
                     nrpspksdomains_PENPOL_c002G03804_cMT.1"
                     /NRPS_PKS="Domain: PKS_KR (2126-2296). E-value: 1.1e-43.
                     Score: 141.1. Matches aSDomain:
                     nrpspksdomains_PENPOL_c002G03804_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (2406-2484). E-value: 6.5e-13.
                     Score: 40.7. Matches aSDomain:
                     nrpspksdomains_PENPOL_c002G03804_PKS_PP.1"
                     /codon_start=1
                     /db_xref="GO:0003824"
                     /db_xref="GO:0008152"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR013217"
                     /db_xref="InterPro:IPR013968"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR014043"
                     /db_xref="InterPro:IPR016035"
                     /db_xref="InterPro:IPR016036"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="PFAM:PF00109"
                     /db_xref="PFAM:PF00550"
                     /db_xref="PFAM:PF00698"
                     /db_xref="PFAM:PF02801"
                     /db_xref="PFAM:PF08242"
                     /db_xref="PFAM:PF08659"
                     /db_xref="PFAM:PF14765"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 208.4; E-value:
                     3e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="PENPOL_c002G03804"
                     /product="hypothetical protein"
                     /protein_id="OQD69647.1"
                     /sec_met_domain="itr_KS (E-value: 1.7e-170, bitscore:
                     556.7, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.2e-80, bitscore: 260.5,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 1.4e-42, bitscore:
                     135.1, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 9.8e-10, bitscore:
                     28.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPEPIAIIGTGCKFPGSASSPSRLWDLLRNPKTVASEPPSTRFD
                     NRSFYDPDPSHPGTTNTKESYFLSEDIRLFDSAFFNISASEAEGIDPQQRLLLETVYES
                     LEIAGQRLEALQGSSTGIFCGVMGNDWEHRVGFDDKAIPRYAATGLARNNIANRVSYFF
                     DWHGPSLVVDTACSSSLVALHQAVTALRQGECSVAVAAGTNLLLHPNIYISTSNLQMLS
                     PNGRGRMWDAKADGYARGEGIGALVLKCLSDAIADGDPIECVIRATGVNQDGRTMGLTM
                     PSSKAQLALIESTYAQAGLDPKTRPEDRCQYFEAHGTGTLAGDPQEASAIYKSFFGDSS
                     QHVSDNDPLYVGSIKTVVGHTEGTAGIAGVIKASLSIQHGTIFPNLLFDELNPELQRFT
                     PRLKVPTETMPWPTLAPNIPRRVSVNSFGFGGTNAHAILESYDIECDENWNGIPPQISN
                     PIVLPFLFSAASARSLGTMLSNYEEYLRSNPKIHLMDLAWTLMKRRSMLAYRVVLCAPT
                     IEVLIIKIREELELRKINNPSTITAQPPSGQKRILGIFTGQGAQWPQMGLDLVTHTSEG
                     RQLFEEMHQSLLSLPIELQPTFSLFDELAAAQPMSRLHEAVLSQPLCAALQIILVNFLT
                     AVGISFETVVGHSSGEIAAAYSAGILSASDCIRVAYLRGRVAGLAGAPNGQPGAMLAVG
                     LSFATANLLCLEPGLQGRVHVAASNSPSSVTLSGDQDAIHEVEQRLQVEGKFARMLRVD
                     TAYHSHHMQPCAKPYLLDMDAAQVKLGLQMNTRWYSSVHDAQEINLDEHGQSLTGEYWK
                     NNMVSPVLFSAALLAALTSDGGPPDVIVEIGPHPALKGPAQQTISDALPSAGGSEIPYI
                     GLSNRGASGIESLANAIGLLCAHLGPNSIDLARYFSLFDHKYTPKVVRGLPAYPFDHRQ
                     RHWFETRKLKNHLHNGGLLHPLLGSLEADTADGEWRWRHYLRREELEWLDGHQIQSRTV
                     FPATGYIAMALEAAGIFAAGQSMRLVQIQRLSIDQAITFSDESSTGIETLFRLSGLQSQ
                     GDQVTGTFNCHANIGGRLVNCASGKLLICWGNPETSMLPSQTPPAADAGAVDIKDFYQS
                     LAKLGYNYTGAFQGITSLARQKDMSTGQIINMGQLSHESSLLFHPVMMDTSLQMLLGAL
                     GAPGDGSLYTLMVPTGIERVTINPAFCGPKGAKAAGRTLFADAFITQLDTDGCSGAVEV
                     FTQEGNGMVQMEGVHISPLGPPDRQRQPFSEIAWGPLTPDAGLHSYPYPADLMNHTLLM
                     EQISLINIKQVVDQLTDKDRSGLDWHRSRVVAWMEHVLAMTRTGKHPTCRSEWLDGTQE
                     DIEVLLERLAPSVTGLLAGVVGANMLRFLRGETSMLEEARKDDVLSRFYKEDPESKTMN
                     DRLGDLVGQIAFRYPRMKILEIGAGSGSATKSILERIGSSYHSYTFTDISPGFFEEAKQ
                     QFAEHQDHFIYQVLNVEKDPSKQGFEDDSYDLVIAANVLHATKSMKDTMTNVRRLLKPG
                     GYLGLMEVTNTSTIGISFCVGGFEGWWAGEGDGRVWGPMLNASNWENVLQDTGFGGIDT
                     ITTLGDARLSAYSVLVSQAVDDRMKVLRQPLSPAHQLKDTAGELVIVGGEKDQTVSLVE
                     EVAHLLEPFFARIVPVQTLELLKGVNISPYATVLSLVDMDGPCFEYLSQSRLQGLQALT
                     VAARKMLWVTTGRECDSPHLGMSKGWLKCLSYEHPEAQYQYLNITDDSTEESTLIAATL
                     MRLVRTDEGNDYSLSSRTSATEPELRFQNGTMSIPRLRASPELNDRYVAGQQLVHKPVN
                     LLESTVRMLPSAKGHYALHLEDKSLVSSHRADIDTELVRIRTRYSTIQAVRVGKDDVFL
                     HLVLGEQEHSHRRLLAYSKDHASIITTPMSWCCDLPDAVRPEFENSFLQATLAAVLARV
                     LVQQATPGSVLWAHEASGVLQQAIRIHAVASGVRPHFTTSSQSLPMEGVSFIHPLVTSR
                     KLVGYLPQDVSVAACFEVEEQGDEGIFSRIKSLLPQCVTVEDTHSLWRTSQQLPEHGNV
                     HHRHLGESLNVASAMAIQFVTSDPTQPVDVKGLSALPPTPRTPKADCIVKWTGSQNEAL
                     NVQVKTASQTLTLSSQKTYLLVGMTGDLGRSICHWLITKGARHVVLTSRSPKVDPHWIQ
                     EMSKLGANVVPMQLDVSNRESLLHVCDKIQKYHPRIGGVVNGALVLNDCAFDEMPLETM
                     QATFAAKVDGSILLDELFRGDLDFFILMGSLTGIVGNWNQSAYSAATGFQSNLIHQRRA
                     RNIVGSIIQPGIITSVGYISRKGSGLAQHVSNTVGSLLLSERDLHEVFAEAILAGHPET
                     SRNPEIVAGMPMANPVTQPDIIWYRNPLCWDFVDYRIQSSSANHAGDGNTCSMKARLES
                     AASMSEAAEIVAAGLADKVRSKFNLASDIALTQDTQLSDLGIDSLVAVDLRSWFVRELS
                     VEIPMLQILSGSSLRALTADSVSKLPPTLLPGILSRDQDFKDVSGLTSPPEVPSDASRS
                     SVSSGMDEIVTPESPSFDQVYRIAGDEMELTKPHQRPIPTPQL"
     gene            11641..19645
                     /locus_tag="PENPOL_c002G03804"
                     /note="ccsA_6"
     mRNA            join(11641..18188,18245..19645)
                     /locus_tag="PENPOL_c002G03804"
                     /product="hypothetical protein"
     aSDomain        11656..12963
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PENPOL_c002G03804_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="8.00E-167"
                     /label="PENPOL_c002G03804_PKS_KS.1"
                     /locus_tag="PENPOL_c002G03804"
                     /protein_end="441"
                     /protein_start="5"
                     /score="547.3"
                     /tool="antismash"
                     /translation="IAIIGTGCKFPGSASSPSRLWDLLRNPKTVASEPPSTRFDNRSFY
                     DPDPSHPGTTNTKESYFLSEDIRLFDSAFFNISASEAEGIDPQQRLLLETVYESLEIAG
                     QRLEALQGSSTGIFCGVMGNDWEHRVGFDDKAIPRYAATGLARNNIANRVSYFFDWHGP
                     SLVVDTACSSSLVALHQAVTALRQGECSVAVAAGTNLLLHPNIYISTSNLQMLSPNGRG
                     RMWDAKADGYARGEGIGALVLKCLSDAIADGDPIECVIRATGVNQDGRTMGLTMPSSKA
                     QLALIESTYAQAGLDPKTRPEDRCQYFEAHGTGTLAGDPQEASAIYKSFFGDSSQHVSD
                     NDPLYVGSIKTVVGHTEGTAGIAGVIKASLSIQHGTIFPNLLFDELNPELQRFTPRLKV
                     PTETMPWPTLAPNIPRRVSVNSFGFGGTNAHAILESY"
     aSModule        11656..19148
                     /complete
                     /domains="nrpspksdomains_PENPOL_c002G03804_PKS_KS.1"
                     /domains="nrpspksdomains_PENPOL_c002G03804_PKS_AT.1"
                     /domains="nrpspksdomains_PENPOL_c002G03804_PKS_DH.1"
                     /domains="nrpspksdomains_PENPOL_c002G03804_cMT.1"
                     /domains="nrpspksdomains_PENPOL_c002G03804_PKS_KR.1"
                     /domains="nrpspksdomains_PENPOL_c002G03804_PKS_PP.1"
                     /iterative
                     /locus_tags="PENPOL_c002G03804"
                     /monomer_pairings="pk -> Me-pk"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       12139..12186
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PENPOL_c002G03804_0001"
                     /evalue="1.40E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="PENPOL_c002G03804"
                     /protein_end="182"
                     /protein_start="166"
                     /score="20.1"
                     /tool="antismash"
                     /translation="GPSLVVDTACSSSLVA"
     CDS_motif       12328..12366
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PENPOL_c002G03804_0002"
                     /evalue="6.10E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="PENPOL_c002G03804"
                     /protein_end="242"
                     /protein_start="229"
                     /score="12.9"
                     /tool="antismash"
                     /translation="WDAKADGYARGEG"
     CDS_motif       12574..12621
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PENPOL_c002G03804_0003"
                     /evalue="3.50E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="PENPOL_c002G03804"
                     /protein_end="327"
                     /protein_start="311"
                     /score="10.1"
                     /tool="antismash"
                     /translation="YFEAHGTGTLAGDPQE"
     CDS_motif       13300..13347
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PENPOL_c002G03804_0004"
                     /evalue="2.90E-04"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="PENPOL_c002G03804"
                     /protein_end="569"
                     /protein_start="553"
                     /score="13.5"
                     /tool="antismash"
                     /translation="IFTGQGAQWPQMGLDL"
     aSDomain        13300..14247
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PENPOL_c002G03804_PKS_AT.1"
                     /evalue="6.50E-80"
                     /label="PENPOL_c002G03804_PKS_AT.1"
                     /locus_tag="PENPOL_c002G03804"
                     /protein_end="869"
                     /protein_start="553"
                     /score="260.5"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="IFTGQGAQWPQMGLDLVTHTSEGRQLFEEMHQSLLSLPIELQPTF
                     SLFDELAAAQPMSRLHEAVLSQPLCAALQIILVNFLTAVGISFETVVGHSSGEIAAAYS
                     AGILSASDCIRVAYLRGRVAGLAGAPNGQPGAMLAVGLSFATANLLCLEPGLQGRVHVA
                     ASNSPSSVTLSGDQDAIHEVEQRLQVEGKFARMLRVDTAYHSHHMQPCAKPYLLDMDAA
                     QVKLGLQMNTRWYSSVHDAQEINLDEHGQSLTGEYWKNNMVSPVLFSAALLAALTSDGG
                     PPDVIVEIGPHPALKGPAQQTISDALPSAGGSEIP"
     CDS_motif       13552..13659
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PENPOL_c002G03804_0005"
                     /evalue="1.00E-10"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="PENPOL_c002G03804"
                     /protein_end="673"
                     /protein_start="637"
                     /score="34.0"
                     /tool="antismash"
                     /translation="GISFETVVGHSSGEIAAAYSAGILSASDCIRVAYLR"
     aSDomain        14488..15006
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PENPOL_c002G03804_PKS_DH.1"
                     /evalue="3.60E-26"
                     /label="PENPOL_c002G03804_PKS_DH.1"
                     /locus_tag="PENPOL_c002G03804"
                     /protein_end="1122"
                     /protein_start="949"
                     /score="84.3"
                     /tool="antismash"
                     /translation="HPLLGSLEADTADGEWRWRHYLRREELEWLDGHQIQSRTVFPATG
                     YIAMALEAAGIFAAGQSMRLVQIQRLSIDQAITFSDESSTGIETLFRLSGLQSQGDQVT
                     GTFNCHANIGGRLVNCASGKLLICWGNPETSMLPSQTPPAADAGAVDIKDFYQSLAKLG
                     YNYTGAFQGI"
     CDS_motif       14572..14649
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PENPOL_c002G03804_0006"
                     /evalue="1.40E-12"
                     /label="PKSI-DH_m2"
                     /locus_tag="PENPOL_c002G03804"
                     /protein_end="1003"
                     /protein_start="977"
                     /score="39.9"
                     /tool="antismash"
                     /translation="WLDGHQIQSRTVFPATGYIAMALEAA"
     CDS_motif       15316..15354
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PENPOL_c002G03804_0007"
                     /evalue="4.70E+01"
                     /label="PKSI-KS_m4"
                     /locus_tag="PENPOL_c002G03804"
                     /protein_end="1238"
                     /protein_start="1225"
                     /score="-1.4"
                     /tool="antismash"
                     /translation="FTQEGNGMVQMEG"
     aSDomain        15805..16425
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PENPOL_c002G03804_cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="1.10E-77"
                     /label="PENPOL_c002G03804_cMT.1"
                     /locus_tag="PENPOL_c002G03804"
                     /protein_end="1595"
                     /protein_start="1388"
                     /score="252.9"
                     /tool="antismash"
                     /translation="SRFYKEDPESKTMNDRLGDLVGQIAFRYPRMKILEIGAGSGSATK
                     SILERIGSSYHSYTFTDISPGFFEEAKQQFAEHQDHFIYQVLNVEKDPSKQGFEDDSYD
                     LVIAANVLHATKSMKDTMTNVRRLLKPGGYLGLMEVTNTSTIGISFCVGGFEGWWAGEG
                     DGRVWGPMLNASNWENVLQDTGFGGIDTITTLGDARLSAYSVLV"
     aSDomain        join(18019..18188,18245..18584)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PENPOL_c002G03804_PKS_KR.1"
                     /evalue="1.10E-43"
                     /label="PENPOL_c002G03804_PKS_KR.1"
                     /locus_tag="PENPOL_c002G03804"
                     /protein_end="2296"
                     /protein_start="2126"
                     /score="141.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="KTYLLVGMTGDLGRSICHWLITKGARHVVLTSRSPKVDPHWIQEM
                     SKLGANVVPMQLDVSNRESLLHVCDKIQKYHPRIGGVVNGALVLNDCAFDEMPLETMQA
                     TFAAKVDGSILLDELFRGDLDFFILMGSLTGIVGNWNQSAYSAATGFQSNLIHQRRARN
                     IVGSIIQ"
     CDS_motif       18022..18120
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PENPOL_c002G03804_0008"
                     /evalue="3.00E-16"
                     /label="PKSI-KR_m1"
                     /locus_tag="PENPOL_c002G03804"
                     /protein_end="2160"
                     /protein_start="2127"
                     /score="51.9"
                     /tool="antismash"
                     /translation="TYLLVGMTGDLGRSICHWLITKGARHVVLTSRS"
     CDS_motif       18444..18554
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PENPOL_c002G03804_0009"
                     /evalue="8.80E-13"
                     /label="PKSI-KR_m4"
                     /locus_tag="PENPOL_c002G03804"
                     /protein_end="2286"
                     /protein_start="2249"
                     /score="40.8"
                     /tool="antismash"
                     /translation="LDFFILMGSLTGIVGNWNQSAYSAATGFQSNLIHQRR"
     aSDomain        18915..19148
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PENPOL_c002G03804_PKS_PP.1"
                     /evalue="6.50E-13"
                     /label="PENPOL_c002G03804_PKS_PP.1"
                     /locus_tag="PENPOL_c002G03804"
                     /protein_end="2484"
                     /protein_start="2406"
                     /score="40.7"
                     /tool="antismash"
                     /translation="ASMSEAAEIVAAGLADKVRSKFNLASDIALTQDTQLSDLGIDSLV
                     AVDLRSWFVRELSVEIPMLQILSGSSLRALTAD"
     gene            complement(21051..23518)
                     /locus_tag="PENPOL_c002G07024"
                     /note="YGR067C"
     mRNA            complement(join(21051..21510,21567..21862,21917..22023,
                     22075..22328,22378..23518))
                     /locus_tag="PENPOL_c002G07024"
                     /product="hypothetical protein"
     CDS             complement(join(21116..21510,21567..21862,21917..22023,
                     22075..22328,22378..23518))
                     /codon_start=1
                     /db_xref="GO:0000981"
                     /db_xref="GO:0003677"
                     /db_xref="GO:0005634"
                     /db_xref="GO:0006351"
                     /db_xref="GO:0006355"
                     /db_xref="GO:0008270"
                     /db_xref="InterPro:IPR001138"
                     /db_xref="InterPro:IPR007219"
                     /db_xref="PFAM:PF00172"
                     /db_xref="PFAM:PF04082"
                     /db_xref="PFAM:PF13465"
                     /locus_tag="PENPOL_c002G07024"
                     /product="hypothetical protein"
                     /protein_id="OQD68940.1"
                     /transl_table=11
                     /translation="MSTEYPLVGSPETSEYPKYECSLCLKRYKRREHLFRHIGSHTSQR
                     PYQCNSCDGAFQRADVLKRHLRTCDGGASRASTRRRACDRCVRQKKACSSHQPCHSCAK
                     KGAQCLYSTDTGYSSRLSQHSSTNHTPKDQELSTQFTNPPPPPSTSTFNTMMPWGLTME
                     DLQNFGTSPTNTFFDPASMQYTSPTLPDFSVLPFEGPATFETPVSSDPPRKSLHFLDKF
                     TSNTGLVSSFDCGTHEQREQIAARLDQQILSELQQRIMSMPALGMDIPSPLIMENNSDT
                     SSTSDLPLDWFNDPLSLKTHEILLLVEEVVTIKPRNSSVALDWSSTLRDACLQFFSPSN
                     IRRFLGFYWAIWHPNVNFVHRPTFDMLAAKPTLLAAMALIGACVSPDMPDNEDARTWFN
                     CVEEMVFIDDDFNSDLTYQYSGNIAIQRRKIQAVQAAYIVCLYQNWEGADASKSRIRRY
                     RFATLVSTARDIGITAARHLNYSELGRHEFEWKEYEAREELIRLFTWIFLLDSAFVIFN
                     NLPPRMVIKEIRMHMATPEACFQATTADECHHQLHLFLPARTLYWTTSFRGSFESLCKD
                     DLSVNIRHLLATLGPLNLFALTSAIHSQIFQFRSAVGSFQLRAPIQNALSNWRDIWQLF
                     SSTFPQGITPHMTIEDPHIQPEELWKRMGFFRYAPEYWLLAHLMADRLAVLGTSKPENE
                     LEPLDEGPLDPILNRYDQTSMRQVNDLIMGFQTFQI"
     gene            complement(25354..26698)
                     /locus_tag="PENPOL_c002G03902"
                     /note="genemark-PENPOL_contig002-processed-gene-12.27-
                     mRNA-1"
     mRNA            complement(join(25354..25870,25932..26136,26193..26698))
                     /locus_tag="PENPOL_c002G03902"
                     /product="hypothetical protein"
     CDS             complement(join(25770..25870,25932..26136,26193..26222))
                     /codon_start=1
                     /locus_tag="PENPOL_c002G03902"
                     /product="hypothetical protein"
                     /protein_id="OQD69889.1"
                     /transl_table=11
                     /translation="MSYKTNYELYSRGSIDSRRSPPPDELLSPLATLYPHVAALQPQYN
                     PSNCTFTGYRDTGYWAAAYTTQTMDDSMSMRRIDGRPCRFVSKLRRLLSRDELKHRRGS
                     RATARTA"
     gene            27784..28428
                     /locus_tag="PENPOL_c002G01050"
                     /note="genemark-PENPOL_contig002-processed-gene-12.12-
                     mRNA-1"
     mRNA            27784..28428
                     /locus_tag="PENPOL_c002G01050"
                     /product="hypothetical protein"
     CDS             27784..28428
                     /codon_start=1
                     /locus_tag="PENPOL_c002G01050"
                     /product="hypothetical protein"
                     /protein_id="OQD69759.1"
                     /transl_table=11
                     /translation="MTNILRLFALVPGSVEQDAERISDRRDRSHEEGMTNPEAQSVLND
                     AEFGRVDPTGWFPHYKNCVQHFVDYSQHTPQVQSIAAFINIRLPCQRPSESSAPMSEST
                     PSSFVSLRPYIRRLIVTAQDSPTVMQGFFGGDWEAGVGCIYKQERVNYMFTAKSSGWAS
                     TKAAYDISPDEETPFLRPLRDPSEDEIRVAEARWSEWLAMEDWMVGARSPW"
     gene            29063..30364
                     /locus_tag="PENPOL_c002G05667"
                     /note="genemark-PENPOL_contig002-processed-gene-12.13-
                     mRNA-1"
     mRNA            29063..30364
                     /locus_tag="PENPOL_c002G05667"
                     /product="hypothetical protein"
     CDS             29063..30364
                     /codon_start=1
                     /db_xref="InterPro:IPR016181"
                     /locus_tag="PENPOL_c002G05667"
                     /product="hypothetical protein"
                     /protein_id="OQD69357.1"
                     /transl_table=11
                     /translation="MAICIYEHDAAKIIPTLVSELPYSTTLLRRIQHGIAYPYETAHIL
                     ATFPPGLTPEPGQPWLAARVDLFAGRTTQMIIYSSLEAEHTSIPPIVTVSDSTEILNVD
                     STSNNSKNNDTNDADNPDINSITKFIVSTFSASPPVLALARAQLLALLEYVKTNMLPFY
                     LSYLAKSAQATSVAAETPPVSTSSVTSNNTSPTSVPLIPAPDPQAFLIGSLHTGLFSLL
                     QQSGSYTLSNPIPNIRVHRFDDPPYYKYFFRRSEFSPEAVCGRSADLPFADLSLPSGYR
                     FHDREGREGVLSKHLDLVQSRTHIPRPRAQLSKIPGMAVYLDSTSSDADEMPIAWGFLG
                     VDGALVTLHVEPEHRGRGLAVPLSKAIMRRGMAVDGVFGAGSVNSEDSQTRERVGAWAH
                     TEVAGYNNASRRVMEKIGGQVLTTVTWTVIELLD"
ORIGIN
        1 agatctcttt tgcctggcgc cggaaccgag caaagaagct gatcgtcgac gttatcaagg
       61 atggagaccc atttccctct cttctcatcc cagagccaat cctcgaccag tttgaatata
      121 ttaactttat gatcctgacg acccgggatt ttaacctggt ccgcgctaac tgcttgcatt
      181 gatatacagc tacccaaatt tgtccggact gggtgaactt aatagtatat cccacatgca
      241 gcagatgata aaccatcata catactcatc atatatactt gacttggcag cttgtggtga
      301 tagttccgga acctttgtac tcaacaattt catcgagact gtcatcgtct gcgaatcgga
      361 ttgatcaaca ttcaaccatt tgccacgcga accatatcaa ctagaaagag ctagcattct
      421 tgcatacaaa acatagatcc cttggaactg tgtaattccg cagaaagcat caatatctcc
      481 accatttctt ccaacatact tttctaggca gtacacacca agcgctgtct gcactcgact
      541 ttcaccgtgt ttgggcgagg ttctcttccg taacagcatc tttatgcctc ttatgagcga
      601 ggatattctc cctccacagc cagcccaacc cgatcgcagc tccaggacca agagcaacaa
      661 aagccgcaac cccataaatt gcaactctga cccaggtggc ctgcatcatt ccggcatatt
      721 tgaggtccca gatgaggtat cccagccaga ggaaggtgga accaaacgtg gatagcatat
      781 cccatttgag aatcgcgcac acgcaggcag caaagggggc ttgtgtagat ggaaccgcag
      841 tgggaaagaa gacacgagcg accgaagaag gtgaggtcca tctactccac atccaaaacc
      901 cggctgcgcc aataaccaag acagtcatgg aaaatttgat aacggggaga tctcgcctca
      961 gaccatgtac tcggtcctcc ttgactgtgc tgggaaagat gcgggagaac aaatatagag
     1021 tgatcgcggt ccatatcggg tgcatttgcc agacaaacag ccatgacttt cgccctgaga
     1081 ctgtcggcca gaagaaggca gccgagagtg ggatgtagta agagacaata atggccggca
     1141 aaacggcaat ggcatagttg agatgcatga ggcgcatgtc ggctcccttg aacacctcga
     1201 tgggactgtt gatgtagtac aagatgtaat acaaagggct gacgcggccc agtcctgcca
     1261 tttggccgta gaaggtgaag agtgttggtc tgtaagatta gctttgattg gaagaagtaa
     1321 ttaaggttgg gggagggcaa gacaggggag gaacatacat ttgagccatg gtcaatgcgt
     1381 tagctcgtcg aattgattca aaagaccata tgctcatgac aatacccaca tcaattgaag
     1441 atgagactgc ctggcttagc gactcatagt tcgtctcgta gaagtcgggt aagtaattaa
     1501 tatatcggag ggaccaactg caagagggaa atttggtaaa tgcacagttc actgtagcta
     1561 ttttggaaaa actcacaggt caccaacccc cttcatacta tagaaccttt gtagcaaagg
     1621 cactgagccc atggccgaag tcatacctcc agattcccag atataacctc gcaaggcaga
     1681 cgcatatttg gcgtccgtgg ctgtctttgc cacaaggaga agggccagaa aaggcaaccc
     1741 tagcagagct cttttgagct tactttcccg ttggccctgg ccctgagtag gattgaaggg
     1801 cagggttcct cgcaatgaag ccttgggcgg agccaggttt tctagcatag tggcacctac
     1861 ccagatctct gaggccatat ctgcagcgaa actgcccata atgggcatgc cgagtcgaac
     1921 gaagaggaac tcgaaccacc ccctcagagc ttgcaaccgg gtagtcatag atgaggcatc
     1981 cacaatagct gtggcccgga cttcgcgact cttctgatat tgagcaaagc attctcgaat
     2041 ctgtgtctct gttgggcctt cttctgggct gtggtcaaac atcgctttga tagaatttag
     2101 tagggctgct gcactctcaa tagaagcact ggcaccagca cccagatttg gggtcatctt
     2161 atgaatgcta tcgccgacgc agacgatacg accccacgac cactgtttga acttggcttc
     2221 ctctaaggca accagaatgg agctctccga gtgctcgtac aggttgccga atgtgagatc
     2281 tggtcggatc tgaatatccg catgacgctg ggcgtatgcc tgggcgtttg cttgagagaa
     2341 gcgagggatt tccaccattt cgtaaactcg gtccatcttc tgcaagatga agtaacatat
     2401 gcggccacag ttgtccgaaa agatgaaaga gctacgatcg tggtcataga tgaagtcggc
     2461 gtccccaatg gcaatgcttc cactcgcttt ggaaatacca aagaggcatt ggtactctgc
     2521 agtcatcgct aataattcat cagccgatag ctttttttaa tcgtcttgaa gagcgcacca
     2581 acccttcttg tccggatcca tgagtcctgg ctcatcgcga tcagctaacc gccacatgta
     2641 ttctcggacc ttgctgtagg ttccatctgc tccaacgaga atgtcccctt cgtaagagca
     2701 gccatcagca cactgaactg ctactccctc ttgtgagcac gtcacattaa tcacagactt
     2761 tttcggtaac agcatgctct tgtcttcgat attgtcgtag agtgtctgca gcagactacg
     2821 tcgaaggcca aaggtcatat cgtatccggt tctgtgtggt gaatataagc gggctgacag
     2881 atgcttcaat tattagatta tattccttac agtgctttcg ccagaggcgt tgacgcggac
     2941 ctcggcatga ttagctcccc tttactattt cgatcccccc accggacaag cggttgctgt
     3001 tgaattggtg agtactaagg gagtagagtg aagtcggctt ctgaaaacat acggcaattt
     3061 tcaaccattt ctcccaagcg ccgagctgat ccaaaatctt gtaaaaggtc agtcgctacc
     3121 tccatgatga agaatctaaa aggagaggta ccctggcacc gttaggcgaa agagcaatgg
     3181 atgcaccaac tgcaacatca aatgcagggc ggcactcaag cagaatgtaa tcaatcccag
     3241 ctttctgcag gaccgaaatt agtagaccat catacattcg gtaaacgcca aatctacctc
     3301 aaaggcactg gctagagtaa ggccagcaac accccctcca acaatgatca ctcggaaagt
     3361 catgaatggc gaaatttgcg gtcggactct ggagagtacg aacagtcgta cgggctttac
     3421 tgttatgatc aagctctcta gtagctaaga acctcccaaa ggagtaccaa atgtagtgct
     3481 tgcatcattc tatagtacca acgagactcc gcactaacca ccttgtgaga atttgattgt
     3541 gcggcaaatc aggtttctcc gtcaagtcaa tgtcaagtat agtgcattcc gtcgcggcca
     3601 gatgttttaa ggtcaccttc cgcttgtggg ccgaccgcgg aatgttcaac caagggacgc
     3661 ggtcaagata cgacggcaag aatttgaata aaactgtcgt acttttgcaa atggtctaga
     3721 cccgagagaa attcaaccaa tgctgtcatg tccgagtttc gtgatggtat cttggacaag
     3781 tggcaatgtg aatgatgaca ctggcatact gagcaggcga aggtatatat tttgggtcaa
     3841 atatagttac atatgcgttg ctatcgctaa acgatagctc cagcaaccgt atcaactctc
     3901 ctttgttgaa tataattatt ccacagtcta gtcggtgctc tttcaccaac aaagctcagc
     3961 atgcatccca gcgccagact ctacaacaac attgccttat ggttctatga ttacttggtg
     4021 cactccattt tcatggtcta tggatggcac tgcccaacga aatcagttgg actcccattc
     4081 ttcagcagcc atgttggccc caagcacatg gacgtcgggg tgggaaccgg ctacttcccc
     4141 gtggctgtac gcaagagtag cagaaaacga aatggtcaat tgaagccaca gtggccccaa
     4201 aagctgatgc tagttgatct gaatcccaac tgcacagcca tggctgctac ccgggtcggg
     4261 gcaccagact gcaccgagac attgacggca gacgtgctcc agcccatccc cgccgctggc
     4321 aagcacgaaa cgttcgattc actctcgctt atgaatgtgc tgcactgtct tcctggaacc
     4381 tccgaatcca aagctcaggc gtttggccac cttaagccct tcctgaagga ggatggcgtc
     4441 ctcttcggct caaccattct cggccgtgga gtcgagcata accgatttgg cagactggtc
     4501 atgtggctgt ccaactcact cgggattttc cacaattatg gagatcatcc agatgacttc
     4561 gttcgtgcgc tccaaaagga tttcaaccag gttgaacatg tcgtggtggg acgcgtcctg
     4621 ttgttcaccg cgaaggagcc caattaggca ttgtacctgt aacttgggtt taatttcagg
     4681 cgggaaacat tgcctagcct cgttgcgttt actgggtttt aaaccattaa taattatggc
     4741 aaagtgcttg aacctcgttg tgtgaatata tggcctgctg aggctactgg acaacgtatc
     4801 taatataatc caacgcttaa ctcatactga acacttcgcg tggagatatt taatggtggc
     4861 ccaataatgc ctgagtattt ctttgctagt atatggcaac tttcgacctt gacattcagt
     4921 aaatcatact caactccttt ttttttgctt tccttcccct tcggttctaa ccttatgctt
     4981 ttttcgctgg ggtgggatgg tcaaagtaga atcaatgaca gcatctaggc tcggatctcc
     5041 atgtaaccgt ccagcctaga aggccatctg gcttccaacg agtagtttca aacttggttg
     5101 gtgactcatg gtggcggatg ctgttatctt tgttattttc aatatccgtc gaactagttg
     5161 acgtcaagaa acattattgg tagattgttt tatgggtatg aggatgccga gttgaaggtt
     5221 cagcagagag gtttccgcgt tctgattgtt caaaggcagc ccagggctcc actatataca
     5281 atccaaccca gtcaattcaa gataccagca acgtccttgt gtcacctcta tttgctatta
     5341 ttcttttgat gctaatcatt gacaaattat ccttcacatt ctcaatccac cagtgcctaa
     5401 tctggaaatg gagaaggctc atttcaaggt agtcatcatt ggaggctcaa ttgccgggtt
     5461 gactcttgca cactgtctcg atcgagcacg gattgattat atagtgttgg aaaagaacca
     5521 taatattcat ccaccggttg gaggttcaat agggttgatg ccaaacgggt ctcgaatcct
     5581 agcgcagttg ggcctttatg accaggttga gaagttgacg agtccaatta aagtctgtca
     5641 tatgggtttc ccagacggct tcagcttcag tgatcaattt cccagaaaga ttcatgaaag
     5701 gcaagtttaa cgtatccaga gtttcccttt tttttgctat gctatgctgg gagctagcta
     5761 accggagaaa acgaatcggc ccaaatagat ttggttttcc tattgcaatt ctcacacggc
     5821 aacaactgat tgaagttctc tatacggcat tgagtgacaa gtcgaaggta aagactggga
     5881 aaaaggtggt taggattgag tcagaagaaa gaagaatcac tacctggact gaggacggta
     5941 gcgaatatga gggtgaactt gtggtcgggg cagatggtgt tcacagtgtg acacgctcgg
     6001 agatgtggcg tgccgcagac aatcaacaac ctggctttat acaggaagaa gagaaataca
     6061 gtgggttccc tgggggcgac agtccttgtt ctcgcaacct gtgctaactc gcaggtcagg
     6121 cctgtctgcc gaatacagct gtatttgggg gctctcaacc ccagtgcccg gaatcagaca
     6181 aggggagcaa attattcgca gctatgacag gttgacgttt ctgatctttc ctagccaaaa
     6241 cggctgcctc ggctggtttg caatccaaaa actcaataga aagcatgtct accccgacat
     6301 ccgtcctttc tcccagaagg atacattagc cagatgtgaa gctctcagag atttgccgat
     6361 atggaacgat gtcaaatttg gggacctatt gacactgact gaagtatgcg ccatgactcc
     6421 gctggaagag aacctgttcc aaacgtggaa ttacggacgt atcctttgca ttggagacag
     6481 catcagcaag gtcagctagc ttgcaatcac tctctatctc tcttgatatc tatttactga
     6541 ccgtaccaca gctgacgcct aacattgcgc aaggcgcgaa tacagccatc gagggcgcgg
     6601 cagctgtggc gaatggactg caccaattac tccaccacaa tggcttgaat cagccgtcat
     6661 atgacgagat ccaggaggtc ctaggccgct actcgcaaag ccagcgaaag cgaatgaaaa
     6721 aattgcattg gatctcgcac atggtcactc gactacagtc gcgagaaggt ttgataaaca
     6781 aatttgttgg acgctacata tattctcata ccggaaactc tacattttat ttgactggca
     6841 aaatgattgc ccagggaccg gtgctgaact atctttcaac tccaaaggag atagaaattg
     6901 gactgcgagc atcgtttgat caatatggaa aggatggagg agatatgcct tggaagacga
     6961 ccatcatgtt tattgcactt ctcactatcg ttgtcttaat ctatagtttt atttgagcgc
     7021 actgttgtgt tgctgtgaag agaatgcgca aacaaacaaa acaatgaatg tatgctcacg
     7081 ggaatgttaa aataggggcc tgtttccgca ataccaggta ggcccaacac attccacaac
     7141 caacctatct agtgatagta caacagccag cctattaacc ggatcctgat ttgtctcccg
     7201 ttttcgaggc acagtttgtc gaattatgcc tgtacaaata aagagctgca gcaccacaag
     7261 gcgacatcat taccgataag aacaaagctt caggtatcaa tctcaaataa ttgataccct
     7321 gagaaatctg ttggcgtctt tgaatgtgga gaccaacagc ccataacagc agtgcaaggc
     7381 tacctaaacc gtaatcccat tgaaagaacc gaagcagacc ctcttcaacc gaggtaactc
     7441 ttctgctagg ccaagcaaga tgaggaacaa agacctttcc ggggcagatg tcggacgaat
     7501 cagcgagcaa tgagataagc aatggaacga gatgagaaat tgttgcgcat gccatggcgg
     7561 aaatgtagat ggaggtacgg gccgtagaga gggtggcctg aaagtccgca gttcggtctt
     7621 tgccacagag atgcgtcaac cacagcatgg cagacaccaa caggggccac ccttgaagca
     7681 gtgcaattat accctgcttt gagccatagg agaccacagc cggagagggc aaggcaagga
     7741 ggatcactaa gatgtagtaa ccacccagca aacagcttct gagattccga cagagatgtc
     7801 cctcggcggc ggatgatggt gaatcatcta gacggtgagt ggaagataga tccaaggaac
     7861 agtaaatggg cagaaaaatg cccggcccca caagcatcag gcccatccca aacatagcca
     7921 tcctatagaa agctaaggtg tcagtaccta taatattcaa ttgttgtaat caccagtgag
     7981 acctacttgc ccatggcacg cgtaggtgaa ttgctttgac tgaattgcaa agcaaacaag
     8041 atccacattt ctcccacccc tactgcagct ggaaaagcaa tcagagacaa ggagcgaagg
     8101 ttaccctgac agaccggcca ataaaagacg acgaaaattc caagggcttt gtcgagagtg
     8161 tcgatgccag tgaaatgagt cctcaatgtc gcatttggag tccctggcag ctgacccttt
     8221 ccagcgaatt cttcgttgcg caaaaatagt ccattccgga aggaggatat ccatacggta
     8281 tagatgccga caagacccag caagagcagg ctgcatcgaa tggtatttac tgctgtggac
     8341 attctgatga ttcttattaa cgtgatgtaa gaaagcccaa cccaaggcga gacttaggct
     8401 tattatgatt aaatgggcga cgtccttacg tagctttcaa aatattccat caatgacaga
     8461 ccagatgcta tacctggcgt ccaaggaagg gagagcaagg agtgtcccaa gtgattgaca
     8521 tcactaactc aacttctccg caactagaat tgtaatgcag cactccttat ctcgatatta
     8581 tggcatagct ccaagctgtg aaaacacgcc acccttggac catggcactg aaatattgtc
     8641 cagaccgagc gaaatgttac cctcttatcc cggaacttgc ttctaggcat ggcttcgttc
     8701 tcccggagta ataaaatgac aaatgacaca acacggaagg gtgaacatgt acaaagtacg
     8761 tcatctttca tgatgggttg gaaagacatc tagcgtacat gtcaaccggc ctataccacg
     8821 ggccgttccc aaaagcctat ccggcggtcc gacaacctta actttaccat ttgcggccag
     8881 ctcggtgggc cgacatgaca gggtaggact atgtactttg gtcaaaaaat tacaagtaaa
     8941 aatattgaaa aattcattat acttatatat aaaattttat ttgatttaca tacatatcct
     9001 atgctatagt tgtcggcaag cctctggcta ctttttcata cgctacttgg catattgcag
     9061 ggacatccag cttcttaata ctgatcactt ttgttgtaat tggaaagaat ggttttcgca
     9121 atgctagtgg tatgctggtc gatcttcttg ggtctttgga tgctagtatc ccgactcaag
     9181 cagtcacgcg acaaaatctg ccccccaaaa ggtacgcaat tacattactt gatgatacga
     9241 gagactggtt gcttcatgat ataacacatt aggccccccg cgcctaccct ggatcggtaa
     9301 cctccaccaa tttccactga agttgcttca cctacggtcg gtatcgcttc aattgcatat
     9361 taaaagcaca cggctgattt tttgatttta catgcaggtt gacggaatgg tcgcgcacct
     9421 atggtggctt ctacacccta aaattagggc cagtcacggc ggccgtgatt accgatcgcc
     9481 aaatagctaa ggaggcattt gacagaaaca gtgcgatctc tagcacgcga cataccaact
     9541 atgccacaga gtttgttaca gatggcactc acctgctgac gatgaagtat ggtgctcttt
     9601 ggcgcgagga acgaaagatc ctacagcaga cgctaaaggg atcggtgtgt gacaatgacc
     9661 acatgcgatt gatcgatgcc gagcagaccc agctgatgag agatcttctg gtaaatccta
     9721 gcgactacag cgcttacatc aaacgggcga gcactagcat catcaccagc ctggtatttg
     9781 gtatccgtac gccttcgtgc gccaccctcc atcttcaaga gcttgatgcc atcaatgatg
     9841 actggctaca actgctggtc attggtggcg cgctctcgga agacgtattt cctgtgttga
     9901 aatacattcc gtcggcattt ttgggcacct tcaccaagcg attgaaaggg atacgccggc
     9961 gtatgcgccg tctctacggg acaatgctaa accagacaat cacccgtcag agggagtctc
    10021 cggccccacc agcccgttca atgatcgatg cagtcctcaa tcagcgggag catttcaatc
    10081 tgacagaccg tcagatcgag gttcttgctg gggttaccct agaaggcggc ttcgacacca
    10141 ccaccagcat gctccttgtg tttgtacaag ccatgacttt gcatccggaa tgtcaagagc
    10201 gcgcttatgt cgaaattaat gccctctgtg gacgccaccg cattcctcag tggagtgacc
    10261 gcaaccaact tccgtatgtc aatatgctcc ttaaggagac gatgcgttgg cggcctgtta
    10321 caactctgtc cccgccgcat gtactggaaa aagataccac cattcgtggg acatttttgc
    10381 cacaaggttc gatgttgatt ctaaacacat ggggactcca tcaagaccca aacgtcttca
    10441 ttgacccaga tcggtttgat cccatgcggt atgagggcta tacgaagttg gctgccgact
    10501 acgccaacgc gcccgatgct gcaacccgtg atcactacac atacggcatc ggccgacgaa
    10561 tctgcccggg gatccatctg gcagatcgta gtatgttctt ggcgatagct aagttaatct
    10621 ggggctttcg gtttgagccc cagcgcgatg agcaagggaa ttcaatcccc attgatagta
    10681 atccggtgac tgggtacacc gtggacaaag ttcagatatc ccccaaaccg ttcgcctgtg
    10741 cggtcattcc acgtgacaaa gaaggagaga agactatttt gcgtgaattt ggtgtcgctt
    10801 ctgaggtttt cgcagattac aatttggatg aaaatgctag cctatagaat gtcactcgat
    10861 atgagctaca gcgcgtagta gctgtgtctg aagaaaatat tgccacgtca tttcttgcat
    10921 tgtcgaggtt tctgtgcagt tggctttcat ttcctcgaat tgacttccct gactagagta
    10981 ctccaacgtc tactctatca tctactcaca atcctcataa tcggatactg gccaatgcat
    11041 gtatcttaga tcaaaactta ccccgttata cagaggttct cgccccaaag ggcctcgact
    11101 cgttctaaca tacatgaaaa tagcagacaa cccagaaatg taacattgat tgcatacttg
    11161 actagctcta gtagatctta ttggtccgga tagagagctt ccgaaatttg tggaaggttt
    11221 atcgcccaat cttcgtccat ggttggcagc caaccttctc cgacgggccg tggcatcgga
    11281 ggagggtatt caagcttgtc taccaacatc attgatagaa gtacaaaatt acattcctta
    11341 tcatagccta ccgtccactg gttgagtaca tgattgcaag gttgcttcgt aaagtgttgt
    11401 cgtcacttcc tgagctcatc aagttccgtc cttgaagtct ccttcagacc ctgacagact
    11461 gtcccggctc tggttcctct gtaaacgctg ctgacgtagg acctaattag ggaatacgag
    11521 ggtgtttgca ttcccttagt atctcgagaa cactggaaat agtatataaa gcaacaggag
    11581 aattctatac ctcaagattt cgacaccaaa gattagcgaa ctcaaatcat tgaaatcgca
    11641 atgacaccag aacctattgc tataattgga acgggatgca aattccctgg ctcggcatca
    11701 tcgccgtctc gcctttggga tctgctgcgt aacccgaaga ccgtggcatc agagcctcca
    11761 tccacccggt ttgataatcg ctctttctac gatcccgatc cttctcaccc tggcactacg
    11821 aacacaaagg agtcctactt cctctccgag gacattcgtc tctttgattc tgccttcttc
    11881 aatatttctg ccagcgaggc tgagggtatt gaccctcagc aacgactgct gctagaaacc
    11941 gtctatgaat ccctagaaat agctggccaa agattagagg ctcttcaggg ctcctcgacc
    12001 ggcattttct gtggtgtaat ggggaatgac tgggagcatc gtgtgggatt cgacgacaaa
    12061 gccattccac gctacgcagc cacgggtctt gcgcggaaca acattgccaa ccgggtttcc
    12121 tacttcttcg actggcatgg cccatcattg gtggtggata cagcgtgctc ctctagtcta
    12181 gttgccctcc atcaggctgt cacggcgttg cgtcagggtg aatgctcagt ggctgtggcc
    12241 gcaggcacca atctactatt gcaccccaac atctacatct caacatccaa cctgcagatg
    12301 ctgtctccaa atggacgtgg ccgcatgtgg gatgctaagg cagacggcta tgcccgcggt
    12361 gaaggtattg gagcccttgt cttgaaatgc ctcagtgacg ccatcgccga cggtgacccg
    12421 attgaatgtg tgattcgggc gactggtgtg aaccaagatg gacgaaccat gggcctcacg
    12481 atgccctcta gcaaggcgca gctggcgttg attgaatcta cgtacgccca agcaggtctt
    12541 gacccgaaaa cacgcccaga agatcgatgt cagtactttg aggctcatgg aactggcacc
    12601 cttgcgggcg atccgcaaga agcgtctgct atctataaga gcttttttgg cgactcttca
    12661 cagcatgtct cggacaatga ccccctctat gttgggtcga tcaagactgt tgtgggacac
    12721 actgaaggta cagcgggaat agcaggcgta atcaaagcct cattgtccat tcagcatggc
    12781 accatcttcc caaacctgct atttgatgag ctcaatcccg agctgcaacg gtttacccct
    12841 cgtttgaagg tgcccactga gaccatgccc tggcctaccc ttgcacccaa tatacctcgt
    12901 cgagtgtcag tcaattcctt tgggtttggg ggtaccaacg cgcatgcgat tctggagagc
    12961 tacgatattg aatgcgatga gaactggaat ggaataccac ctcagatttc caatcctatc
    13021 gtactcccat tccttttctc tgccgcctcg gctcgcagcc tcggcaccat gctgagcaat
    13081 tacgaagaat acctccgaag caatcccaaa attcatctga tggatctggc ctggaccctg
    13141 atgaagcgac gatctatgtt agcgtaccga gtggttttgt gcgctccgac aatcgaggtg
    13201 ctgatcatca agatccgcga agagctcgag ctgagaaaaa ttaacaaccc ttccaccatt
    13261 actgcgcagc ccccgagcgg ccagaaacga atcttgggta tcttcaccgg gcaaggcgcg
    13321 cagtggccgc agatggggct ggaccttgtt acgcatacct cagaagggag acaattgttc
    13381 gaggagatgc atcaatcact tctaagtctt ccaattgagc ttcaaccaac attctccctc
    13441 tttgatgagc tggcggcggc acaacctatg tctcgcctgc acgaggcagt actgtcccag
    13501 cccctctgtg cggctctgca aattattttg gtgaacttcc tcaccgcggt aggtatttca
    13561 ttcgaaacag tcgtgggtca ctcctctggc gagatcgctg cagcatacag cgccggaatt
    13621 ctgtccgcgt cggattgcat ccgagtggcc tacctgcgcg gccgcgttgc gggcctggca
    13681 ggtgcgccaa acggtcaacc gggggctatg ttggctgttg gtctttcctt cgcaacggca
    13741 aatcttcttt gccttgagcc aggcctacaa ggccgagtgc atgtggcggc gagcaactcg
    13801 ccatccagtg tcacactttc aggagaccag gacgccatcc acgaggtcga gcaacgactt
    13861 caggttgagg gaaagtttgc tcgcatgctt cgtgtggaca ctgcatacca ttcgcatcac
    13921 atgcaacctt gtgcaaagcc atacctgctg gatatggatg cagctcaggt taagctgggt
    13981 ttgcagatga ataccagatg gtactcaagc gtacatgatg ctcaggagat caacctggat
    14041 gaacatggac agagccttac cggtgagtat tggaagaata acatggtcag tcctgttctc
    14101 ttctcggcag ctttgctcgc agcactcaca tctgacggtg gcccgcctga tgtgattgtc
    14161 gaaattggcc ctcatcccgc tttaaaagga ccagcgcagc aaacaatttc agatgcgttg
    14221 ccgtcagcag gcggatcgga aatcccctac attggtctct ccaatcgggg agccagtggt
    14281 attgaatcct tggccaatgc catcggtttg ctctgcgccc atttgggacc caattccatt
    14341 gatttggccc gttacttctc actctttgat cataaatata cacccaaggt ggttcggggt
    14401 ctcccagcat atccctttga tcatcgacag cgccactggt tcgagacacg caagctcaag
    14461 aaccacttgc acaacggcgg tctacttcat ccactacttg ggtccttgga agcagacaca
    14521 gcggacggag agtggcgctg gcgtcactac ctgcgccgcg aagagctcga gtggctggac
    14581 ggtcaccaga ttcaatcccg tacagtgttc cccgccactg gttatatcgc catggcactc
    14641 gaagcggctg gtatctttgc tgctggccaa agcatgcgac tggtgcagat tcagcggctc
    14701 tctattgacc aggcaattac cttctctgac gaaagttcga ccggaattga aacgctcttc
    14761 cggttgagcg gccttcagtc ccagggggat caagttacag gaactttcaa ctgtcatgcc
    14821 aatattggcg gaagattggt aaactgtgcg tcgggtaagt tgctgatctg ctggggcaac
    14881 cctgagacca gcatgctacc ttcacagacc ccaccagctg ccgatgcggg agccgtagac
    14941 atcaaagact tctaccaatc cttagcaaag ctggggtata actacacagg tgccttccag
    15001 ggcattacct cccttgcccg gcaaaaggac atgtccaccg ggcagattat caatatgggc
    15061 cagctcagcc acgagtcgtc actattgttc catccagtga tgatggatac cagcttgcag
    15121 atgcttctgg gtgccttagg tgccccgggt gatgggagct tgtatacact tatggtacca
    15181 actggaatcg agcgcgttac catcaacccc gctttctgtg gaccaaaggg ggctaaggct
    15241 gcggggagga ccttgtttgc ggatgccttc atcacccagc tcgacacaga cggttgttcc
    15301 ggggccgtgg aagtgttcac gcaggaagga aatggcatgg tccagatgga gggagtccac
    15361 atttcgccac tcggcccgcc agatcgccaa cgtcagccct tctctgagat tgcttggggt
    15421 ccgctcacac cggatgctgg attgcactcg tatccttacc cagcagacct catgaaccat
    15481 accttgttga tggagcagat ctccctcatc aacattaagc aagtggtgga tcaacttacg
    15541 gacaaggatc gcagcggcct tgactggcac cgctcgcgtg tcgtcgcctg gatggagcac
    15601 gtactggcga tgacacgcac gggcaaacat ccgacctgcc ggtcagagtg gctggatggt
    15661 acacaggagg acattgaggt gctcctggag cgccttgccc cttctgttac cggactttta
    15721 gcgggggtgg taggagccaa tatgctgcgc ttcctgcgcg gcgaaacttc catgctggag
    15781 gaagcccgaa aggacgatgt cctaagtcga ttctacaaag aggatcctga gtccaagaca
    15841 atgaatgacc gactcggtga tctagtcggc caaatcgcct ttcgctatcc tcgtatgaag
    15901 attctggaga tcggcgcggg ctcggggtcg gccaccaagt ccatcctgga gcgtatcggc
    15961 tcatcctatc actcctacac tttcaccgac atctccccag ggttctttga ggaagcgaag
    16021 cagcagtttg ccgagcatca ggatcatttc atataccagg tactcaatgt cgaaaaggat
    16081 ccttctaagc agggttttga ggacgatagc tacgacctgg tcatcgccgc caacgtccta
    16141 catgcgacta agtcaatgaa ggacaccatg accaacgtcc gtcgcttgct gaagccgggt
    16201 ggctacctag gtctgatgga agtgacaaac accagcacga tcggtatctc tttctgcgtc
    16261 ggcggcttcg agggttggtg ggcgggcgaa ggcgacggtc gcgtctgggg accaatgctg
    16321 aatgcttcca actgggagaa tgtcctgcag gacactgggt ttggtggcat tgacactatt
    16381 accacgttgg gggatgcccg gctcagcgcc tattccgtgc tcgtctctca ggcagtcgac
    16441 gaccgcatga aagttctccg ccaacctttg tctccagccc accaactcaa agacacagct
    16501 ggggaactgg taattgttgg tggggagaaa gaccagactg tgagcttggt agaggaagtc
    16561 gcacatctcc tggaaccgtt tttcgcacga attgttcccg tgcagaccct ggagttgctc
    16621 aaaggggtaa acatatcccc ctacgccact gtactgtcct tggtagatat ggatggccca
    16681 tgcttcgagt atctcagtca atctcgtctt caaggccttc aggccctcac agtagcggca
    16741 agaaagatgc tgtgggtgac caccggtcgc gagtgtgact ctccccatct cggtatgagc
    16801 aaaggatggc tcaaatgtct ctcatacgag catccagagg ctcaatacca atacctcaac
    16861 atcacagacg acagcaccga ggagtcgacc ctaattgcag ctaccctgat gcgtctcgtg
    16921 cgtaccgatg agggtaatga ttactctcta tcctcccgga cttccgcaac agagccagag
    16981 ttgcgctttc agaacggcac catgagtatt ccacgtctgc gggccagccc cgaattgaat
    17041 gatcggtacg tggctggtca acagctcgta cacaaaccag tcaaccttct ggagtcaacc
    17101 gtacgcatgc tgccctcagc aaaaggacac tatgcccttc acctggaaga caagtcacta
    17161 gtttcgtcgc acagggcaga catagacaca gagctcgtcc gcatccgcac ccggtattct
    17221 acaattcagg cagtgagggt gggtaaggac gatgttttcc tgcatcttgt cctcggagaa
    17281 caggaacaca gtcatcggcg gctgcttgca tactccaagg atcatgcctc catcattacc
    17341 acaccaatga gctggtgctg cgatttacca gatgcagtgc gaccagagtt tgaaaattcg
    17401 ttcttgcaag ccaccctagc tgccgtgcta gcccgcgtcc tggtgcagca ggcgacccca
    17461 gggtcggtgc tctgggccca tgaagcaagt ggagtgctgc aacaagccat ccgcatccac
    17521 gctgtcgcca gtggtgtgcg cccgcatttc accaccagca gtcaatccct ccctatggaa
    17581 ggcgtatcct tcatccaccc tctggtaacc agccgtaagc ttgttggtta cctcccccag
    17641 gatgtttcag ttgcagcgtg ttttgaagta gaagagcagg gggatgaagg aatcttttca
    17701 cgaatcaagt cacttttacc acaatgtgtg acagttgagg acacacatag cctgtggcgc
    17761 acctcacagc agctcccaga acacggaaat gttcatcatc gccacctcgg ggagtcactc
    17821 aacgttgcct ccgcaatggc catccagttc gttacgtctg atccaaccca gccggttgat
    17881 gtgaagggac tttcggcgtt acccccgaca ccccgtacac caaaggcgga ctgcattgtt
    17941 aaatggactg ggtctcagaa cgaggctctt aatgtacaag tgaagaccgc cagccagact
    18001 ttgacccttt ccagccagaa aacgtacctt ttggtgggta tgacgggcga tttgggccgg
    18061 tctatctgcc actggctgat cactaagggc gctcggcacg ttgtccttac aagtcgaagc
    18121 ccaaaggttg atcctcattg gatccaggaa atgtccaaac ttggggcaaa tgtggttcca
    18181 atgcagctgt aagttgctgt ctgttcctca atatcaacgg acattaagct aatcttagtt
    18241 tcagggatgt gtcgaatcgt gaatccctcc tccatgtctg tgacaagatt caaaaatatc
    18301 accctcgcat tggaggcgtg gtgaatggcg ctctcgttct aaacgactgt gccttcgatg
    18361 agatgccgct ggaaaccatg caagccacat tcgcagccaa agtcgacggc agcatcctgc
    18421 tggacgagtt gttccgtggt gacctggact tcttcatcct gatgggctcc ctcactggca
    18481 ttgttggcaa ctggaaccag tcagcctact ccgcggccac aggcttccaa tcgaatctca
    18541 ttcaccaacg acgcgcacga aacatcgttg gcagcatcat acaaccagga atcatcacca
    18601 gcgtgggcta tatctcacgg aaggggagcg gcctagccca gcatgtcagc aacaccgtcg
    18661 ggtccctcct cctctctgaa cgcgatctcc acgaggtatt tgcggaagcc atcttagccg
    18721 gtcatcctga aacaagccgc aacccggaga tcgtggctgg catgccgatg gccaatccag
    18781 tcacgcagcc tgacatcatt tggtatcgaa atccgctgtg ctgggacttt gtcgactacc
    18841 gaatccagtc atcgtcagcc aaccatgcag gcgatggtaa tacctgctcc atgaaggctc
    18901 gactcgaatc cgctgccagc atgagtgagg ctgcggagat tgttgctgca ggccttgccg
    18961 acaaggtccg tagcaaattt aacctcgcgt cggatattgc cctgacgcaa gacacgcagc
    19021 tgagcgacct gggcatcgac tcgctagtgg cagttgatct gcgcagttgg ttcgtcagag
    19081 agttatctgt tgagatccca atgcttcaga tcttgagcgg ctcgtctctc cgggccctta
    19141 ctgcggattc cgtgtcgaag ctcccaccca ccttgttacc cggtatactg agcagagatc
    19201 aggatttcaa ggatgtgtct ggtctcacaa gtccgccaga ggtcccgtct gacgcatcgc
    19261 gatcctcggt tagttctggt atggacgaga tagttacgcc agagtctccc agctttgacc
    19321 aggtataccg tatagctgga gacgagatgg aattaaccaa gccccatcaa aggccaattc
    19381 ccaccccaca gctataaaag ggcgactagt ggattcctgt atgtgtttga ttacactcgt
    19441 tcgagtgtga acctttctca actaaaggtg catcagaacc aacagagtta tccaaataca
    19501 cacactgaat agcaattaac ctggaccgca cgttatgtgt atgtagcctc gggtttccct
    19561 cggctaaaaa caaccatctt tattatgctt tctctcgctc tgattccatc aagcggttct
    19621 gcccccagta ggtgtttgtt tgtcgaccat aatgcctttt caaacttata tctataatcg
    19681 attgcatgac cttcaatcaa ccttgtatgc ctaagccact cggaataacc ttgaaagaca
    19741 atgccaagca caaagagtcg aagtgcacac gaaaatagct caatacagag atccatgatc
    19801 catcgcaaag tatttggctg cctcgggctg tgaattcgaa aatcgaagac caaaatagtt
    19861 tccaggattc caagtgatgt gcatgtataa tcaggcagaa ttaaggtaat tttagcttgc
    19921 tgacgtgatt tgctttcgac tatccggtgg atcccttggc gtgtcagcaa cttgcatcgt
    19981 atgcccaggt gcccaggtgt tcgatttgaa aatccggttg ccttcccaaa cgattatacc
    20041 tttcttctgc tgtggctgat taacattgtg gggaactgca ggctctgggc gctgtggata
    20101 gttaaaataa aatccatgta catagctagt tacagcgttt ctttttaggt taccagttga
    20161 ctgaactgct aggaaggtat gacacaagaa ggaaaaacct agttatattc tgctacatgt
    20221 tcatacctca acacattgag gcgactgttg taagaacctc cactgtcatc aacgctgata
    20281 aactcggctt aagtccgtgc caagaccact cagccaccta atacgttatc atccaataag
    20341 cgccaagagg tcatcctcat gggccaaact tgtaaacctt gggggaacta aatccaaaat
    20401 gctaatccaa ctccagacta aggttattaa gttaggtcaa aactcaaaat acccttggag
    20461 gccgctatat aaccaaacca acaccccatt tttcttacct gggcacttat ccatctcaaa
    20521 gcttcaaacc cttcgacggc tgttttaccg caaaccagaa tgttctttcg gccgttattt
    20581 accacattcc tggtcctcct tctcagcttt ctggctacag gcgcggctat aggcgctcgg
    20641 tctgtgggga tttctgggcc tgacaacacc ctcgaagcta cgactcagac aataatacaa
    20701 ccacaaccaa tccacgatgc accatcaaca actgctcttc ctccgagaca cgaacatgaa
    20761 gatgattgca taatacccag gctccacgaa acaacaatcg actggagaga ggacgggtct
    20821 gagtctctcc gactagaatc agaacgtgag gccgggtttc ttccgagttc ccatcatgag
    20881 aggtaaacgt tgcatccagt tgcgatcagc ccagtcacta acagaatttg tcagtgatta
    20941 cccaaccctt gagttgtggc ctttgttcaa gatctgtatc gtttcagcaa tagcgatttg
    21001 tgtcctcaag ataatccggg acttgaagag ataaccaata cataaaaaag caaatcatga
    21061 catttattca tttcttgtag tgagacattt taattataca gcagggcccc atctttcaaa
    21121 tctggaatgt ctgaaagccc ataatcaaat cattaacctg gcgcatacta gtttggtcat
    21181 atcgattcag gattgggtcc agtgggccct cgtcgagcgg ctccaactca ttctccggct
    21241 tagatgtgcc aagtactgcc aatcggtctg ccatcaggtg agctaggagc cagtactccg
    21301 gggcataacg gaagaatccc attcgtttcc agagctcctc gggttgaatg tgaggatctt
    21361 cgattgtcat atgtggcgtg attccttggg ggaacgtcga cgagaacaac tgccagatgt
    21421 cccgccagtt gctgagtgca ttttggatcg gggctcggag ttggaagcta cctaccgcgc
    21481 tgcggaattg gaagatttgt gaatggattg ctaatggtta cagtaattaa caaagttcga
    21541 tcatggatgt ttgcactgta gcttacctga tgttaatgcg aataaattta atggacccag
    21601 ggtagcgagg aggtggcgga tattgacgga taaatcgtct ttacatagtg actcgaagga
    21661 cccacggaat gaggtggtcc agtagagagt tcttgcaggc agaaagagat ggagttggtg
    21721 gtggcattcg tctgccgttg tggcttgaaa gcaagcttct ggtgttgcca tatgcatcct
    21781 tatttctttg atgaccattc gcggaggaag gttgttaaaa ataacgaatg ctgaatctag
    21841 taaaaagatc caagtgaaca aactatggtt taggagtatc agtgactatt tgttccagcg
    21901 caatattgag acctaccgaa tgagttcctc tctagcttca tattctttcc attcgaactc
    21961 atggcggcct agctcgctgt agttcagatg tctcgccgcc gtaatgccaa tatcacgagc
    22021 ggtctttggt acattaatac actgatgagg tagcagactg aaaggtacac ttacagatac
    22081 cagagtagca aaacggtaac gtcgaatgcg actcttgcta gcatccgcac cctcccaatt
    22141 ctgatagaga catactatgt aggccgcctg tacagcctga atcttgcgtc tttgaatagc
    22201 tatgttgcca gagtattggt aggtcaaatc actgttgaaa tcgtcgtcaa tgaaaaccat
    22261 ttcttccaca cagttgaacc aagtgcgcgc atcttcgttg tcaggcatat ctggtgatac
    22321 gcaagcacct ttcaataatt agcgtttacc aggctctaca ataggagact gcctcaccaa
    22381 ttagagccat tgcagctagg agcgttggct tcgctgccag catgtcgaag gtaggccggt
    22441 gcacaaagtt cacattagga tgccatattg cccaatagaa ccccagaaat ctccttatgt
    22501 tcgaaggaga gaagaattgc agacatgcat ccctgagtgt tgatgaccag tccaaggcaa
    22561 cagaactgtt gcgcggtttg attgtgacca cttcttcgac taaaagaaga atctcgtgtg
    22621 ttttcaagga aagtgggtca ttgaaccaat ccagtggtaa gtcgctagtt gaacttgtat
    22681 cactattatt ttccatgatc aaaggagatg gaatatccat gcctaaggcc ggcattgaca
    22741 ttattctctg ctgtaactca gacaggattt gctgatctaa tctggcagca atttgttctc
    22801 tttgctcatg ggtgccacaa tcaaagctcg acactagacc tgtgttgcta gtaaacttgt
    22861 ccaggaagtg cagcgatttc cggggggggt cactagaaac aggtgtttcg aaagttgccg
    22921 ggccttcgaa aggtaatacc gaaaagtccg gcaaagttgg actggtgtat tgcatggagg
    22981 ctggatcaaa aaaggtattg gtcggacttg tgccaaagtt ttgcaagtcc tccatagtga
    23041 ggccccacgg catcattgta ttaaatgtcg atgtcgatgg cggtggcggt gggttcgtga
    23101 attgggtact cagttcttgg tctttcggtg tatgattcgt tgagctatgc tggcttaatc
    23161 gtgacgaata tcccgtgtct gtagaataca aacactgagc accctttttg gcgcagctgt
    23221 gacatggttg gtgggagcta caagcctttt tctgacgaac gcaacgatcg caagcccgtc
    23281 ttcgagtgct tgctctcgag gcgccgccat cacaggtccg caggtgtcgc tttaaaacat
    23341 cagcgcgctg gaaagctccg tcgcacgaat tgcattggta tggccgctgt gatgtatggg
    23401 agccgatgtg gcgaaacagg tgttcacgtc gcttataccg cttgaggcat aatgagcact
    23461 cgtattttgg gtattctgat gtctcagggc ttcctactaa aggatattca gttgacattt
    23521 ttgatcagaa atcttttttt ggtccaagtc cgggagtgtc cgggggaatg gtcgcggggt
    23581 gagcggtggg gcgacaaatg ttagagttct ggcgcggctg cgttgatcgg tacttgggcg
    23641 tcggtctatg attcttcaca tttctttcac atatgccgac tacttggtgg cttgttgcat
    23701 tatgctacgt gattcattat ggacattcca tgcgttcttc ttgtgcccag aaagagagag
    23761 gcaaaaaaaa ggggtataat caaggatact ctcaaaggtt ttatataact agttaactag
    23821 ttagtcatat tttatactta acccaatcct actaaaagca attactactt tgtcctatgg
    23881 tttggctttc caggtctata tatatacaat atagggtgag gattctagta tttacctctg
    23941 atactattag tcgaagtgtg gcgcagggat tgattctccc tggagctaaa catatacaat
    24001 ataatctcgt tccgggtcat tgacgtcatt agcaagctcg atggggaaca ttgttattgt
    24061 attatattat attcgtatcg tattattata ttcgtatcgt attcttatta tattcgtatc
    24121 gtattcttat tatattctta ttgaacgata ctctgatctc gtggcagtca cccgggtttg
    24181 atgaataata ctaaattacc ccctgcatcc aacccgatat cgcaggctag agcgcgaaga
    24241 gcgcgaagag caatagggat gatcatgaag tatcctctcc ttgcccaggt gctatattgc
    24301 agttgagtac cagtatgaac ccttccctat aatcttattc caataatccg tttctcctat
    24361 agcctttatc cctttctcat tcaattcctt caaactgaaa aaaaaagata actatactgt
    24421 cagctgcatt tactctcacc ctggcgcaat ggaatggtcc ttcccgatcc gccctagcgt
    24481 caagataatc aagaagaagc aaaaaagaaa aacatggaaa agaaaaatag cgaatgcacg
    24541 acgttgcacc caaagcacgc gttaggcaca tatttcaaat accttgtggg ggccatggtg
    24601 atcgacacgg gtcggcccct tagtgttaaa acgcctagcc atgggagttt cccaatctct
    24661 aggaaagtcg attctataga aaacaaggtt caaaccccgg cagtacgtgc atatgtagct
    24721 tgtgtcaccc ctgaaacttt gtatcatata gttctgcagg aacaaagcat ctcgtgcctg
    24781 aacgttaagt cattgcaata ttgggattgc aatatctgcc cattgggcca tacctgcggg
    24841 tatcttgcca ttacacgaat aattgataac aatcacccgg gttctaaggc tccaggtaat
    24901 tataactgtg gctagaactc catgggcatg tggagctcgc tgatcattgc tcgctgaggt
    24961 gataatgttt gaggtgatgg gcggtttagg ggcctgatgc aagtgatcgg ggtttggcgc
    25021 gtgtgcaccc tcggatgatc ctacatcatg tgtactgatc ctgttccttt cccccgggaa
    25081 tgcaggggtc acgaatgcta ccgggggatc gtgaaccata agggtatagt tctagaaaaa
    25141 gcaaatatgc tatgccgtca ttgcttcagg tgtgccttgc ttccaagatt ggcatgtggc
    25201 tttctcctac tcatatgaac aagggacact gggccccgat tacctggtaa ctccctgatt
    25261 gaaaaacgtg cgttttggcg gaaaaaaccc cttgccgaga cttagaattg tacggaatac
    25321 gacttggaga ttttctaaaa gtaaaaaagt agatattctt ggtaaaaagt ggactgtaat
    25381 tggtcctttg tttgatatct gtaggcaaat ctgcctttat atacattggc ataaaatata
    25441 tatgcaatcc aatgaagtca caagaataga aaagatgcag cctccaatgt acatatgacg
    25501 ccaatgtgtg ccaaagaact cctcgctgta atgccgcttg cccaaaaacc caaaggaaaa
    25561 aagatacgct cgcaagaatg agaaccaaga tcaaacaaaa gaaaaaggtg gatgcgaagt
    25621 tgtggttgtt aaggcctcgg tgccgagtat gaagatgtcc gaaaaagagt agcctcatat
    25681 aagaggaatc gctggtcgtt tgcatgttgt tcgagtagat cgccaagggc aaaaaaggaa
    25741 aaaagaataa tgaaagagag agagacagtt catgcagttc gagcagtcgc ccgagatcct
    25801 cgacggtgtt ttaactcgtc tcggctgagg agtcggcgta gtttagaaac aaatcggcat
    25861 ggtcgaccat cttaggcaat gttagaacta aatgcgatcg aagtaaaaaa gacagacagg
    25921 aataagctta ccaatgcgac gcatggacat ggaatcatcc atagtctgtg ttgtgtaggc
    25981 cgcagcccaa tatcccgtgt cacggtaacc ggtgaaggtg cagttgctgg gattatactg
    26041 tggctgcagg gccgcgacat gcgggtagag cgttgccaac ggtgagagaa gctcatctgg
    26101 cgggggtgac cgtctgctgt cgatgcttcc tcgagactga aaaaaatata agtcagattg
    26161 attaacttaa gtaaagcatg ggttttactc acgtaaagct catagttggt cttgtaactc
    26221 atggtgggta tgtagtgggt gttgcgttga agtggtgttt ttgtatatca cacaaaagtc
    26281 tcatatgcaa gatgacgact cgatcacgaa accttaacaa ttgcgtgttg agtgtgttga
    26341 gatgcaggtt tgaccagaag cgaaccggct tgcatttaaa tcaaatggaa atgctcagcc
    26401 gcagaaattt ggaagcgggg gagatcagga tgtcaagctg attcgcatct agtagcgcat
    26461 ctagtagcct agtttgattt ttcatagatt ggattttctt acacccgggt agtcgggttt
    26521 tcacacatcg atgaaggtga atggcgtcct tctcattgga tgagatggag atgagatgga
    26581 ggggctgtct gagcgtcagg gccgatcggt cggggtcccc gatgtgggca agtctctata
    26641 cgagaggact catttgaact gggatcatcc ctgcatatgc ccacgaatcc tgtcatctcg
    26701 ttctactttt cccccttgct tcttttcttt tttttctctg tgttcttcct tccacgtttt
    26761 atttttattt tccttgagtc ccaaaacatg tgctatagat aagagcaggg aaacctagag
    26821 aataactcgc agatccatgg atcccaaatg tgatatgaga ttcacacccg aacaggtccg
    26881 ggatcctacc tttttaggtc aatgaataac tatccatatg tttaattatt atttggagtg
    26941 gaccttgaag cgtcagccat gtcgcacagg tcacgaattg agactaccta agcgagtata
    27001 ttagagaaga ctaaacacta aaaaaagtat gggaaagatg agatcagtga tcttccgcta
    27061 gttttaaggc ttccaaatca tttcagagtg atctagggcg agatagtgct agagactagc
    27121 ctcgaatgta ttgaactatt gagacactac tccgtaagag atctagatcg accatgtggg
    27181 ctgcctgatt gggactagtg gacaattcca ttgtcggttc agaacacagc cacacacccc
    27241 ttgctatttc gggatagcgc acaagccaca tattcggtct caccgtggct caaaccgtgg
    27301 ctcaccgtgg ctagtgatca tatctgtggc tcaagcttgg tttctcttcg atagcttccc
    27361 agatccaccc caccctgcct tcacctccga aaagcccgaa ctagtccgcc cttgatcttc
    27421 acaggttatc gatttttttg ggcacccttg atggttcggt cttccccgtc cgcgctgggt
    27481 cgcggagcta taaggcgttc gcctccccca gaattataga ctattccaac tcaagtctaa
    27541 atccacttcc agtttcaaac attcttcctt tgtgcctcct atcaacaaca tatgtcgact
    27601 gtcgaacatg tcactgagca tgcagggttc tggaagagag tgctgggaaa actctcagca
    27661 tatggagatg cgcgatcctt attctcgcga acaactcgct caaagtgagt tccttcctcc
    27721 atcacttccc tcacttccct cgcttccctc tactccggtc ttgtttattg caccggctac
    27781 acaatgacca atattctgag actttttgcc cttgttccag gatccgtcga acaagacgct
    27841 gaacgaattt cggataggcg cgaccgctct catgaagagg ggatgaccaa cccagaggct
    27901 cagtcggtgt tgaacgacgc cgagtttggt cgcgtggatc ccacaggctg gtttccacac
    27961 tacaagaatt gtgttcagca cttcgtcgac tatagccaac acacacccca agtgcagtcc
    28021 attgcggcgt tcatcaatat tcgactaccc tgtcagcggc cttccgagtc tagcgctccc
    28081 atgtcggaat ctacaccatc atcctttgtt tcgctacggc catacattag acggttaatt
    28141 gtcacggcac aggactcacc gactgtgatg caaggcttct tcggtggtga ttgggaggct
    28201 ggcgtgggct gtatctacaa acaagaacgg gtgaactata tgttcacggc taagagcagt
    28261 gggtgggcat ctacaaaggc tgcctatgac atctctccag atgaagagac tcccttcttg
    28321 aggcccctgc gtgacccctc agaggatgag attcgagtag ccgaagcacg ttggagcgaa
    28381 tggctagcaa tggaggattg gatggtcgga gcgcgcagtc cctggtagga tgtcccgcgg
    28441 tcatgaggca cgaatttctt ttgttctttt cgtttttctg tttttcccct tatgtttctc
    28501 gttccccaaa aaaatatagt gctttatgat gtcatatcac agtggagtat aatgacaagg
    28561 ccgtcatttt ctgttatttc gctctatgtg ccctggggaa agtttgccaa acctaaaaca
    28621 tagcaataca gaattataag caaaaaaata atttgtttcg tctcgcacat gcagagttga
    28681 cagagatcgc ctgcgggtcc cgcgtcagaa tcgatagtgc cgccccgcca cagccacaga
    28741 ccacctgggc agtcttggag attcacacaa gtgacaaata cttaagcgac tcgaagaagc
    28801 attcatccgt cggactccgt ttactaatca aatattctca agtcagatat ctaaccagac
    28861 ttagctaggc acaatttaac catgtagtga tccacaagtc tctgactcac gaccccctca
    28921 tgactgtcaa cctgtcactt gcgaataaat tgaagatcaa tagtctcttc aagtttatga
    28981 cttgagatcc attcatcgac ccgtgtagaa attcagcccc tcccctgaac ccaggttccg
    29041 ggaacccgac acatcgatcg gaatggcgat atgcatctac gagcacgatg cagccaaaat
    29101 aatcccgaca ctcgtatctg aactgccata ttccacgact ttgctccgac gaatccaaca
    29161 tggaatcgcg tatccgtatg agaccgccca catactggca actttcccgc ccggtttaac
    29221 ccctgaacct ggacagccat ggctggctgc gcgagtggat cttttcgctg gccgcacaac
    29281 acaaatgatc atttactcca gcctcgaagc ggagcacacg tcaattccgc cgatcgtcac
    29341 tgtcagcgat agtacggaga tattaaatgt ggactcaaca tccaataata gcaagaacaa
    29401 tgatactaat gatgccgaca atcctgatat caactccatc accaagttca ttgtttccac
    29461 cttttccgcc agcccacccg tcctagccct ggcccgcgcg cagctattgg ctttgctgga
    29521 atatgtcaag actaatatgc tgccattcta cctatcatac ttggcgaagt cagcccaagc
    29581 cacatccgtg gcagctgaaa ctcctcccgt atcgacgtcc tcggtgacct caaacaacac
    29641 cagtcccact agtgtccccc tgatccccgc gccggatcca caggcttttc tcatcggcag
    29701 ccttcataca ggtctattct ctctcctaca gcaatcgggc tcttacaccc tatctaaccc
    29761 gatacccaat atccgggtcc atcgcttcga tgatccgcct tattacaagt actttttccg
    29821 gagatctgag ttcagccccg aggcagtgtg tggaagatct gccgatctgc cgttcgccga
    29881 tctttccctc ccatccggat ataggttcca tgaccgagag gggagggagg gtgttctgag
    29941 taagcacctg gatcttgtgc agagtcggac acatatcccc aggccaaggg cacagctatc
    30001 taaaattccc ggtatggcgg tttacttgga ctctacctct agtgatgctg atgaaatgcc
    30061 tattgcatgg ggattcttgg gtgtggatgg agccctggtg acattgcatg ttgagccgga
    30121 gcatcggggt cgcggacttg cggttccatt gtctaaggct atcatgcgtc gcggaatggc
    30181 agtagatggt gtttttggag ctggaagtgt caactctgag gatagtcaga ctcgagagcg
    30241 tgttggagct tgggcacata ctgaggtggc tgggtataat aacgcgagtc ggagggtcat
    30301 ggaaaagatt ggcggtcagg ttttaacaac tgtcacatgg actgtcattg agctgcttga
    30361 ttaaatgttt cttatatcct tggtcttcaa gaggatagcg aggtggacac cgacaagacg
    30421 ctgatacact tcattaaact gctgcgaatt atgagatgaa gtctatagcg tcttgaatat
    30481 ggtggccctg accacagtct tttcatgggc gatgataaag ttcaaattgt tgtgaaagct
    30541 ctcgaaggcc agctccattc gtggcaggaa agccttccac ttgaaatatc ccaacacggt
    30601 gggtcttcat tagacctctg catagcccat taatgggggc ccatcaaagc ccatcaaaag
    30661 cccatttcta tgcacaaata tagtcttggc atacataaag tagctgatta atggctgtat
    30721 tttacgcatg taccaaccta tatcttcagt catattatat tattatagca agaagcagga
    30781 attgagtaga tattatactg atcttagcat cgggatgcta gatttcatac aaaattaccc
    30841 caaaaagatc caatttgacc atgaatccgt acttaggagg aattactgag tatcagtata
    30901 aagagatata tattatctat agagaggatt gataccactt tctctactca a
//
